locus-tag	class	description
THEOS_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THEOS_RS00015	COG0592	DNA-directed DNA polymerase activity
THEOS_RS00020	COG0148	phosphopyruvate hydratase activity
THEOS_RS00025	COG0469	pyruvate kinase activity
THEOS_RS00035	COG0284	orotidine-5'-phosphate decarboxylase activity
THEOS_RS00040	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
THEOS_RS00050	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
THEOS_RS00055	COG1013	pyruvate-flavodoxin oxidoreductase activity
THEOS_RS00060	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THEOS_RS00060	COG0674	pyruvate-flavodoxin oxidoreductase activity
THEOS_RS00070	COG1937	Protein conserved in bacteria
THEOS_RS00075	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THEOS_RS00085	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THEOS_RS00090	COG0693	protein deglycase activity
THEOS_RS00095	COG0494	nUDIX hydrolase
THEOS_RS00100	COG3956	TIGRFAM MazG family protein
THEOS_RS00110	COG2847	Copper chaperone PCu(A)C
THEOS_RS00115	COG1999	signal sequence binding
THEOS_RS00125	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
THEOS_RS00135	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
THEOS_RS00140	COG0459	protein refolding
THEOS_RS00145	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THEOS_RS00150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THEOS_RS00165	COG0166	Belongs to the GPI family
THEOS_RS00170	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
THEOS_RS00175	COG1612	heme a metabolic process
THEOS_RS00175	COG0109	protoheme IX farnesyltransferase activity
THEOS_RS00180	COG2010	Cytochrome c
THEOS_RS00180	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
THEOS_RS00185	COG1845	cytochrome c oxidase, subunit III
THEOS_RS00185	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
THEOS_RS00270	COG1304	FMN binding
THEOS_RS00280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THEOS_RS00290	COG0668	transmembrane transport
THEOS_RS00295	COG3253	May function as heme-dependent peroxidase
THEOS_RS00325	COG2205	protein histidine kinase activity
THEOS_RS00335	COG1355	regulation of microtubule-based process
THEOS_RS00370	COG1489	DNA binding
THEOS_RS00385	COG1115	amino acid carrier protein
THEOS_RS00415	COG0442	prolyl-tRNA aminoacylation
THEOS_RS00425	COG0277	FAD linked oxidase domain protein
THEOS_RS00440	COG0822	iron-sulfur transferase activity
THEOS_RS00445	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THEOS_RS00455	COG2132	Multicopper oxidase
THEOS_RS00475	COG2226	methyltransferase
THEOS_RS00485	COG5002	protein histidine kinase activity
THEOS_RS00490	COG0745	RESPONSE REGULATOR receiver
THEOS_RS00520	COG0577	efflux transmembrane transporter activity
THEOS_RS00520	COG1136	(ABC) transporter
THEOS_RS00525	COG4181	ATPase activity
THEOS_RS00540	COG1082	Xylose isomerase domain protein TIM barrel
THEOS_RS00555	COG0723	plastoquinol--plastocyanin reductase activity
THEOS_RS00560	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
THEOS_RS00570	COG0719	Fe-S assembly protein
THEOS_RS00575	COG0719	Fe-S assembly protein
THEOS_RS00580	COG0396	ATPase activity
THEOS_RS00595	COG0446	pyridine nucleotide-disulphide oxidoreductase
THEOS_RS00605	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
THEOS_RS00615	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
THEOS_RS00640	COG0505	Belongs to the CarA family
THEOS_RS00655	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
THEOS_RS00655	COG0165	Argininosuccinate lyase
THEOS_RS00660	COG0165	Argininosuccinate lyase
THEOS_RS00665	COG0137	argininosuccinate synthase activity
THEOS_RS00675	COG0508	dehydrogenase complex catalyzes the overall conversion of
THEOS_RS00685	COG1024	Enoyl-CoA hydratase
THEOS_RS00690	COG0632	four-way junction helicase activity
THEOS_RS00695	COG1011	Hydrolase
THEOS_RS00705	COG1611	Belongs to the LOG family
THEOS_RS00710	COG0589	response to stress
THEOS_RS00720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
THEOS_RS00730	COG1940	carbohydrate kinase activity
THEOS_RS00775	COG0302	gtp cyclohydrolase
THEOS_RS00790	COG1217	gtp-binding protein TYPA
THEOS_RS00800	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
THEOS_RS00810	COG0395	ABC-type sugar transport system, permease component
THEOS_RS00815	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THEOS_RS00815	COG0574	Belongs to the PEP-utilizing enzyme family
THEOS_RS00825	COG3005	denitrification pathway
THEOS_RS00835	COG1131	(ABC) transporter
THEOS_RS00855	COG0556	nucleotide-excision repair
THEOS_RS00860	COG0497	DNA recombination
THEOS_RS00870	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THEOS_RS00875	COG0745	RESPONSE REGULATOR receiver
THEOS_RS00880	COG2205	protein histidine kinase activity
THEOS_RS00885	COG0704	Plays a role in the regulation of phosphate uptake
THEOS_RS00905	COG1546	Belongs to the CinA family
THEOS_RS00905	COG1058	Belongs to the CinA family
THEOS_RS00910	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
THEOS_RS00920	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
THEOS_RS00920	COG1418	mRNA catabolic process
THEOS_RS00925	COG1077	Cell shape determining protein MreB Mrl
THEOS_RS00930	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THEOS_RS00940	COG0085	RNA polymerase activity
THEOS_RS00950	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
THEOS_RS00950	COG0235	Class ii aldolase
THEOS_RS00965	COG4143	(ABC) transporter
THEOS_RS00970	COG1177	transmembrane transport
THEOS_RS00975	COG1660	Displays ATPase and GTPase activities
THEOS_RS00980	COG0391	Required for morphogenesis under gluconeogenic growth conditions
THEOS_RS00995	COG0436	Aminotransferase
THEOS_RS01000	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
THEOS_RS01005	COG0227	Belongs to the bacterial ribosomal protein bL28 family
THEOS_RS01015	COG0628	permease
THEOS_RS01025	COG0343	queuine tRNA-ribosyltransferase activity
THEOS_RS01030	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
THEOS_RS01035	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
THEOS_RS01050	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THEOS_RS01060	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
THEOS_RS01065	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
THEOS_RS01080	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THEOS_RS01120	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
THEOS_RS01130	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THEOS_RS01140	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THEOS_RS01140	COG0515	serine threonine protein kinase
THEOS_RS01145	COG0251	oxidation-reduction process
THEOS_RS01165	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THEOS_RS01170	COG1028	Short-chain dehydrogenase reductase Sdr
THEOS_RS01185	COG0717	Belongs to the dCTP deaminase family
THEOS_RS01195	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
THEOS_RS01200	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
THEOS_RS01205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THEOS_RS01215	COG0583	DNA-binding transcription factor activity
THEOS_RS01220	COG3546	catalase activity
THEOS_RS01225	COG0758	DNA mediated transformation
THEOS_RS01225	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THEOS_RS01230	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
THEOS_RS01245	COG2759	Belongs to the formate--tetrahydrofolate ligase family
THEOS_RS01260	COG0301	tRNA thio-modification
THEOS_RS01275	COG0261	This protein binds to 23S rRNA in the presence of protein L20
THEOS_RS01280	COG0211	Belongs to the bacterial ribosomal protein bL27 family
THEOS_RS01285	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THEOS_RS01290	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
THEOS_RS01305	COG0799	negative regulation of ribosome biogenesis
THEOS_RS01315	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
THEOS_RS01350	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
THEOS_RS01355	COG0825	malonyl-CoA metabolic process
THEOS_RS01370	COG0049	tRNA binding
THEOS_RS01385	COG0051	transcription antitermination factor activity, RNA binding
THEOS_RS01395	COG0088	Forms part of the polypeptide exit tunnel
THEOS_RS01400	COG0089	rRNA binding
THEOS_RS01405	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
THEOS_RS01410	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
THEOS_RS01420	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
THEOS_RS01425	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
THEOS_RS01430	COG0255	Belongs to the universal ribosomal protein uL29 family
THEOS_RS01490	COG0201	protein transport
THEOS_RS01495	COG0563	adenylate kinase activity
THEOS_RS01505	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
THEOS_RS01515	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
THEOS_RS01520	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
THEOS_RS01525	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
THEOS_RS01530	COG0202	RNA polymerase activity
THEOS_RS01535	COG0203	ribosomal protein L17
THEOS_RS01565	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
THEOS_RS01570	COG0142	geranyltranstransferase activity
THEOS_RS01575	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
THEOS_RS01600	COG0366	Alpha amylase catalytic
THEOS_RS01610	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
THEOS_RS01615	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
THEOS_RS01625	COG0047	phosphoribosylformylglycinamidine synthase activity
THEOS_RS01635	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THEOS_RS01640	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
THEOS_RS01650	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
THEOS_RS01665	COG0497	DNA recombination
THEOS_RS01710	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
THEOS_RS01715	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
THEOS_RS01720	COG0113	porphobilinogen synthase activity
THEOS_RS01735	COG0631	protein serine/threonine phosphatase activity
THEOS_RS01740	COG2815	serine threonine protein kinase
THEOS_RS01740	COG0515	serine threonine protein kinase
THEOS_RS01770	COG0210	DNA helicase
THEOS_RS01775	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
THEOS_RS01780	COG1011	Hydrolase
THEOS_RS01805	COG0537	adenosine 5'-monophosphoramidase activity
THEOS_RS01810	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THEOS_RS01820	COG0135	phosphoribosylanthranilate isomerase activity
THEOS_RS01825	COG0483	inositol monophosphate 1-phosphatase activity
THEOS_RS01830	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
THEOS_RS01835	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THEOS_RS01840	COG0714	Associated with various cellular activities
THEOS_RS01845	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THEOS_RS01845	COG0574	Belongs to the PEP-utilizing enzyme family
THEOS_RS01850	COG1272	protein, Hemolysin III
THEOS_RS01860	COG3850	Histidine kinase
THEOS_RS01860	COG5002	protein histidine kinase activity
THEOS_RS01890	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
THEOS_RS01925	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THEOS_RS01930	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
THEOS_RS01935	COG1611	Belongs to the LOG family
THEOS_RS01945	COG1193	negative regulation of DNA recombination
THEOS_RS01950	COG1166	arginine decarboxylase activity
THEOS_RS01965	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
THEOS_RS01985	COG0601	transmembrane transport
THEOS_RS01990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THEOS_RS01995	COG0101	tRNA pseudouridine synthase activity
THEOS_RS02000	COG3842	ATPase activity
THEOS_RS02025	COG1764	response to oxidative stress
THEOS_RS02035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THEOS_RS02050	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
THEOS_RS02055	COG0220	tRNA (guanine-N7-)-methyltransferase activity
THEOS_RS02070	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
THEOS_RS02080	COG2720	vancomycin resistance protein
THEOS_RS02085	COG1187	pseudouridine synthase activity
THEOS_RS02095	COG1028	Short-chain dehydrogenase reductase Sdr
THEOS_RS02100	COG0492	ferredoxin-NADP+ reductase activity
THEOS_RS02110	COG0792	nuclease activity
THEOS_RS02115	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
THEOS_RS02120	COG1160	GTP binding
THEOS_RS02145	COG0736	holo-[acyl-carrier-protein] synthase activity
THEOS_RS02150	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
THEOS_RS02150	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
THEOS_RS02155	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
THEOS_RS02160	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
THEOS_RS02165	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
THEOS_RS02170	COG1450	Type ii and iii secretion system protein
THEOS_RS02195	COG0473	3-isopropylmalate dehydrogenase activity
THEOS_RS02230	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
THEOS_RS02240	COG0860	N-Acetylmuramoyl-L-alanine amidase
THEOS_RS02245	COG2815	serine threonine protein kinase
THEOS_RS02245	COG0515	serine threonine protein kinase
THEOS_RS02250	COG1752	Esterase of the alpha-beta hydrolase superfamily
THEOS_RS02265	COG1139	Iron-sulfur cluster binding protein
THEOS_RS02270	COG0247	lactate metabolic process
THEOS_RS02300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THEOS_RS02320	COG2244	polysaccharide biosynthetic process
THEOS_RS02330	COG1216	Glycosyl transferase, family 2
THEOS_RS02375	COG2205	protein histidine kinase activity
THEOS_RS02395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THEOS_RS02405	COG1324	tolerance protein
THEOS_RS02410	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
THEOS_RS02415	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
THEOS_RS02420	COG0739	heme binding
THEOS_RS02425	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THEOS_RS02430	COG2197	response regulator
THEOS_RS02445	COG0776	regulation of translation
THEOS_RS02455	COG1515	deoxyribonuclease V activity
THEOS_RS02465	COG1482	cell wall glycoprotein biosynthetic process
THEOS_RS02470	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
THEOS_RS02475	COG0372	Belongs to the citrate synthase family
THEOS_RS02480	COG1132	(ABC) transporter
THEOS_RS02485	COG1132	(ABC) transporter
THEOS_RS02500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THEOS_RS02505	COG0601	transmembrane transport
THEOS_RS02510	COG0747	negative chemotaxis
THEOS_RS02540	COG0174	glutamine synthetase
THEOS_RS02545	COG0737	Belongs to the 5'-nucleotidase family
THEOS_RS02565	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THEOS_RS02570	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
THEOS_RS02575	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
THEOS_RS02580	COG0788	formyltetrahydrofolate deformylase activity
THEOS_RS02585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THEOS_RS02595	COG2358	TRAP transporter, solute receptor (TAXI family
THEOS_RS02600	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
THEOS_RS02605	COG2358	TRAP transporter, solute receptor (TAXI family
THEOS_RS02615	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
THEOS_RS02620	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THEOS_RS02625	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
THEOS_RS02645	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THEOS_RS02660	COG0746	molybdenum cofactor guanylyltransferase activity
THEOS_RS02700	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THEOS_RS02710	COG0167	dihydroorotate dehydrogenase activity
THEOS_RS02720	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
THEOS_RS02730	COG0540	Belongs to the ATCase OTCase family
THEOS_RS02735	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
THEOS_RS02745	COG0730	response to heat
THEOS_RS02750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THEOS_RS02765	COG0312	modulator of DNA gyrase
THEOS_RS02780	COG1960	acyl-CoA dehydrogenase activity
THEOS_RS02785	COG0456	acetyltransferase
THEOS_RS02795	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
THEOS_RS02800	COG0009	L-threonylcarbamoyladenylate synthase
THEOS_RS02815	COG1459	type II secretion system
THEOS_RS02830	COG0277	FAD linked oxidase domain protein
THEOS_RS02840	COG0287	Prephenate dehydrogenase
THEOS_RS02845	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
THEOS_RS02860	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
THEOS_RS02865	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
THEOS_RS02880	COG1609	Transcriptional regulator
THEOS_RS02885	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THEOS_RS02890	COG0179	Fumarylacetoacetate (FAA) hydrolase
THEOS_RS02900	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
THEOS_RS02905	COG0151	Belongs to the GarS family
THEOS_RS02910	COG5002	protein histidine kinase activity
THEOS_RS02910	COG2176	DNA-directed DNA polymerase activity
THEOS_RS02915	COG0745	RESPONSE REGULATOR receiver
THEOS_RS02920	COG5002	protein histidine kinase activity
THEOS_RS02925	COG0617	tRNA 3'-terminal CCA addition
THEOS_RS02925	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THEOS_RS02925	COG0517	IMP dehydrogenase activity
THEOS_RS02935	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
THEOS_RS02945	COG0217	transcriptional regulatory protein
THEOS_RS02950	COG4651	solute:proton antiporter activity
THEOS_RS02950	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
THEOS_RS02955	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
THEOS_RS02960	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THEOS_RS02965	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
THEOS_RS02970	COG1674	ftsk spoiiie
THEOS_RS02985	COG0517	IMP dehydrogenase activity
THEOS_RS02995	COG0745	RESPONSE REGULATOR receiver
THEOS_RS03030	COG3845	ABC transporter
THEOS_RS03035	COG1744	ABC transporter substrate-binding protein PnrA-like
THEOS_RS03045	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
THEOS_RS03050	COG0133	tryptophan synthase activity
THEOS_RS03055	COG0159	tryptophan synthase activity
THEOS_RS03060	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
THEOS_RS03070	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
THEOS_RS03095	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
THEOS_RS03100	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
THEOS_RS03130	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
THEOS_RS03140	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
THEOS_RS03145	COG2385	sporulation resulting in formation of a cellular spore
THEOS_RS03150	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
THEOS_RS03160	COG0194	GDP metabolic process
THEOS_RS03165	COG1758	RNA polymerase activity
THEOS_RS03170	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THEOS_RS03175	COG1438	arginine binding
THEOS_RS03180	COG2095	MarC family integral membrane protein
THEOS_RS03185	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
THEOS_RS03190	COG0328	RNA-DNA hybrid ribonuclease activity
THEOS_RS03215	COG4274	PFAM GYD family protein
THEOS_RS03220	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THEOS_RS03220	COG0519	Catalyzes the synthesis of GMP from XMP
THEOS_RS03225	COG1854	S-ribosylhomocysteine lyase activity
THEOS_RS03230	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
THEOS_RS03235	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
THEOS_RS03240	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
THEOS_RS03245	COG0193	aminoacyl-tRNA hydrolase activity
THEOS_RS03250	COG1181	Belongs to the D-alanine--D-alanine ligase family
THEOS_RS03270	COG2255	four-way junction helicase activity
THEOS_RS03275	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
THEOS_RS03295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
THEOS_RS03300	COG0232	Belongs to the dGTPase family. Type 2 subfamily
THEOS_RS03305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THEOS_RS03310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THEOS_RS03320	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
THEOS_RS03325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THEOS_RS03330	COG0333	Belongs to the bacterial ribosomal protein bL32 family
THEOS_RS03350	COG1714	RDD family
THEOS_RS03355	COG0616	signal peptide processing
THEOS_RS03360	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
THEOS_RS03365	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THEOS_RS03370	COG0443	Heat shock 70 kDa protein
THEOS_RS03375	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THEOS_RS03380	COG0484	heat shock protein binding
THEOS_RS03385	COG0789	Transcriptional regulator
THEOS_RS03390	COG0542	response to heat
THEOS_RS03435	COG0490	domain, Protein
THEOS_RS03440	COG0475	glutathione-regulated potassium exporter activity
THEOS_RS03455	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THEOS_RS03455	COG0617	tRNA 3'-terminal CCA addition
THEOS_RS03455	COG0517	IMP dehydrogenase activity
THEOS_RS03460	COG0475	glutathione-regulated potassium exporter activity
THEOS_RS03470	COG0305	Participates in initiation and elongation during chromosome replication
THEOS_RS03475	COG1007	ATP synthesis coupled electron transport
THEOS_RS03480	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THEOS_RS03485	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THEOS_RS03490	COG0713	ATP synthesis coupled electron transport
THEOS_RS03495	COG0839	Belongs to the complex I subunit 6 family
THEOS_RS03500	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THEOS_RS03505	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
THEOS_RS03510	COG1034	ATP synthesis coupled electron transport
THEOS_RS03515	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
THEOS_RS03520	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
THEOS_RS03525	COG0649	NAD binding
THEOS_RS03530	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THEOS_RS03535	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THEOS_RS03540	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THEOS_RS03545	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
THEOS_RS03555	COG4712	double-strand break repair protein
THEOS_RS03600	COG0778	Nitroreductase
THEOS_RS03605	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THEOS_RS03610	COG0131	Imidazoleglycerol-phosphate dehydratase
THEOS_RS03615	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
THEOS_RS03620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THEOS_RS03625	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
THEOS_RS03655	COG0861	Integral membrane protein TerC family
THEOS_RS03660	COG2151	metal-sulfur cluster biosynthetic enzyme
THEOS_RS03665	COG0281	malic enzyme
THEOS_RS03680	COG0404	The glycine cleavage system catalyzes the degradation of glycine
THEOS_RS03685	COG0509	glycine decarboxylation via glycine cleavage system
THEOS_RS03690	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THEOS_RS03695	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THEOS_RS03700	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THEOS_RS03710	COG0437	4 iron, 4 sulfur cluster binding
THEOS_RS03715	COG0243	molybdopterin cofactor binding
THEOS_RS03725	COG2197	response regulator
THEOS_RS03730	COG3851	Histidine kinase
THEOS_RS03735	COG0196	riboflavin kinase activity
THEOS_RS03750	COG1574	metal-dependent hydrolase with the TIM-barrel fold
THEOS_RS03765	COG2813	Specifically methylates the guanine in position
THEOS_RS03770	COG0527	aspartate kinase activity
THEOS_RS03795	COG4956	integral membrane protein (PIN domain superfamily)
THEOS_RS03800	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
THEOS_RS03805	COG0542	response to heat
THEOS_RS03810	COG0423	glycine-tRNA ligase activity
THEOS_RS03815	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
THEOS_RS03835	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THEOS_RS03835	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THEOS_RS03840	COG1024	Enoyl-CoA hydratase
THEOS_RS03845	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
THEOS_RS03855	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
THEOS_RS03865	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THEOS_RS03870	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
THEOS_RS03875	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
THEOS_RS03885	COG0183	Belongs to the thiolase family
THEOS_RS03900	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
THEOS_RS03905	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
THEOS_RS03930	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
THEOS_RS03935	COG1254	Belongs to the acylphosphatase family
THEOS_RS03945	COG1063	alcohol dehydrogenase
THEOS_RS03950	COG2133	pyrroloquinoline quinone binding
THEOS_RS03960	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
THEOS_RS03965	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
THEOS_RS03990	COG0420	3'-5' exonuclease activity
THEOS_RS03995	COG0419	ATPase involved in DNA repair
THEOS_RS04005	COG0728	peptidoglycan biosynthetic process
THEOS_RS04010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THEOS_RS04020	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
THEOS_RS04035	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
THEOS_RS04045	COG1269	ATP hydrolysis coupled proton transport
THEOS_RS04055	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
THEOS_RS04060	COG1527	subunit (C
THEOS_RS04065	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
THEOS_RS04070	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
THEOS_RS04075	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
THEOS_RS04080	COG1394	ATPase activity, coupled to movement of substances
THEOS_RS04115	COG1337	RAMP superfamily
THEOS_RS04145	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
THEOS_RS04160	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
THEOS_RS04165	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
THEOS_RS04170	COG1085	galactose-1-phosphate uridylyltransferase
THEOS_RS04185	COG1126	abc transporter atp-binding protein
THEOS_RS04195	COG2358	TRAP transporter, solute receptor (TAXI family
THEOS_RS04230	COG1129	ABC transporter
THEOS_RS04235	COG4603	Belongs to the binding-protein-dependent transport system permease family
THEOS_RS04240	COG1079	Belongs to the binding-protein-dependent transport system permease family
THEOS_RS04260	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THEOS_RS04265	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
THEOS_RS04270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THEOS_RS04270	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THEOS_RS04280	COG0793	Belongs to the peptidase S41A family
THEOS_RS04285	COG2884	Cell division ATP-binding protein ftsE
THEOS_RS04290	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
THEOS_RS04310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THEOS_RS04325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THEOS_RS04330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THEOS_RS04335	COG2719	SpoVR family
THEOS_RS04340	COG2718	Belongs to the UPF0229 family
THEOS_RS04345	COG2766	serine protein kinase
THEOS_RS04355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THEOS_RS04365	COG2137	regulation of response to DNA damage stimulus
THEOS_RS04390	COG1692	metallophosphoesterase
THEOS_RS04395	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
THEOS_RS04400	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THEOS_RS04420	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THEOS_RS04420	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THEOS_RS04450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THEOS_RS04460	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
THEOS_RS04465	COG1397	ADP-ribosylglycohydrolase
THEOS_RS04470	COG2239	Acts as a magnesium transporter
THEOS_RS04480	COG0228	four-way junction DNA binding
THEOS_RS04490	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
THEOS_RS04495	COG0336	Belongs to the RNA methyltransferase TrmD family
THEOS_RS04500	COG0335	large ribosomal subunit rRNA binding
THEOS_RS04505	COG2197	response regulator
THEOS_RS04510	COG1760	l-serine dehydratase
THEOS_RS04515	COG2897	thiosulfate sulfurtransferase activity
THEOS_RS04520	COG2738	Putative neutral zinc metallopeptidase
THEOS_RS04530	COG0450	alkyl hydroperoxide reductase
THEOS_RS04540	COG1196	nuclear chromosome segregation
THEOS_RS04555	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
THEOS_RS04565	COG1268	BioY protein
THEOS_RS04580	COG0126	phosphoglycerate kinase activity
THEOS_RS04585	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
THEOS_RS04590	COG0824	Thioesterase
THEOS_RS04605	COG1355	regulation of microtubule-based process
THEOS_RS04610	COG1353	crispr-associated protein
THEOS_RS04610	COG0617	tRNA 3'-terminal CCA addition
THEOS_RS04615	COG0237	dephospho-CoA kinase activity
THEOS_RS04645	COG1857	crispr-associated protein
THEOS_RS04665	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
THEOS_RS04680	COG0742	ribosomal rna small subunit methyltransferase
THEOS_RS04685	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
THEOS_RS04690	COG0138	bifunctional purine biosynthesis protein purh
THEOS_RS04695	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THEOS_RS04700	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
THEOS_RS04720	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
THEOS_RS04735	COG0436	Aminotransferase
THEOS_RS04750	COG0149	triose-phosphate isomerase activity
THEOS_RS04755	COG3239	Fatty acid desaturase
THEOS_RS04760	COG4943	cyclic-guanylate-specific phosphodiesterase activity
THEOS_RS04765	COG1490	D-aminoacyl-tRNA deacylase activity
THEOS_RS04770	COG1307	EDD domain protein, DegV family
THEOS_RS04775	COG1307	EDD domain protein, DegV family
THEOS_RS04780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THEOS_RS04815	COG1136	(ABC) transporter
THEOS_RS04830	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THEOS_RS04840	COG1012	belongs to the aldehyde dehydrogenase family
THEOS_RS04845	COG2368	4-hydroxyphenylacetate
THEOS_RS04850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
THEOS_RS04880	COG2050	protein possibly involved in aromatic compounds catabolism
THEOS_RS04885	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
THEOS_RS04900	COG0477	Major facilitator Superfamily
THEOS_RS04905	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
THEOS_RS04940	COG3396	Phenylacetate-CoA oxygenase
THEOS_RS04960	COG2030	dehydratase
THEOS_RS04960	COG1012	belongs to the aldehyde dehydrogenase family
THEOS_RS04965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THEOS_RS04985	COG1404	Belongs to the peptidase S8 family
THEOS_RS05005	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
THEOS_RS05010	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
THEOS_RS05020	COG0183	Belongs to the thiolase family
THEOS_RS05025	COG1331	Highly conserved protein containing a thioredoxin domain
THEOS_RS05040	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
THEOS_RS05050	COG2193	ferroxidase activity
THEOS_RS05055	COG1733	regulation of RNA biosynthetic process
THEOS_RS05065	COG1980	fructose-bisphosphate aldolase activity
THEOS_RS05070	COG4974	Belongs to the 'phage' integrase family
THEOS_RS05075	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THEOS_RS05085	COG1111	helicase
THEOS_RS05085	COG1205	dead DEAH box helicase
THEOS_RS05105	COG1960	acyl-CoA dehydrogenase activity
THEOS_RS05110	COG2199	diguanylate cyclase activity
THEOS_RS05125	COG2151	metal-sulfur cluster biosynthetic enzyme
THEOS_RS05145	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
THEOS_RS05175	COG2181	nitrate reductase activity
THEOS_RS05190	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
THEOS_RS05205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THEOS_RS05215	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
THEOS_RS05230	COG1252	NADH dehydrogenase
THEOS_RS05235	COG0535	radical SAM domain protein
THEOS_RS05240	COG2010	Cytochrome c
THEOS_RS05250	COG2832	Protein of unknown function (DUF454)
THEOS_RS05260	COG3256	nitric oxide reductase
THEOS_RS05265	COG2010	Cytochrome c
THEOS_RS05295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THEOS_RS05300	COG3191	aminopeptidase activity
THEOS_RS05315	COG0714	Associated with various cellular activities
THEOS_RS05325	COG2304	oxidoreductase activity
THEOS_RS05330	COG2304	oxidoreductase activity
THEOS_RS05340	COG4221	oxidoreductase activity
THEOS_RS05350	COG2873	o-acetylhomoserine
THEOS_RS05355	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
THEOS_RS05370	COG0405	Gamma-glutamyltransferase
THEOS_RS05390	COG1028	Short-chain dehydrogenase reductase Sdr
THEOS_RS05405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THEOS_RS05415	COG1940	carbohydrate kinase activity
THEOS_RS05465	COG1385	rRNA (uridine-N3-)-methyltransferase activity
THEOS_RS05470	COG2264	protein methyltransferase activity
THEOS_RS05480	COG0489	protein tyrosine kinase activity
THEOS_RS05520	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
THEOS_RS05525	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
THEOS_RS05535	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
THEOS_RS05540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THEOS_RS05570	COG2001	Belongs to the MraZ family
THEOS_RS05575	COG0275	rRNA processing
THEOS_RS05590	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
THEOS_RS05600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THEOS_RS05605	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
THEOS_RS05610	COG0772	Belongs to the SEDS family
THEOS_RS05615	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THEOS_RS05620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THEOS_RS05625	COG0812	UDP-N-acetylmuramate dehydrogenase activity
THEOS_RS05645	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
THEOS_RS05690	COG2391	methyltransferase activity
THEOS_RS05705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THEOS_RS05715	COG1562	ergosterol biosynthetic process
THEOS_RS05720	COG0415	Belongs to the DNA photolyase family
THEOS_RS05745	COG0463	Glycosyl transferase, family 2
THEOS_RS05750	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
THEOS_RS05755	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
THEOS_RS05765	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
THEOS_RS05775	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
THEOS_RS05780	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
THEOS_RS05780	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
THEOS_RS05785	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
THEOS_RS05800	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
THEOS_RS05805	COG2304	oxidoreductase activity
THEOS_RS05810	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
THEOS_RS05810	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
THEOS_RS05820	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THEOS_RS05820	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THEOS_RS05825	COG0779	Required for maturation of 30S ribosomal subunits
THEOS_RS05830	COG0195	Participates in both transcription termination and antitermination
THEOS_RS05835	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
THEOS_RS05845	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THEOS_RS05845	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THEOS_RS05850	COG1804	L-carnitine dehydratase bile acid-inducible protein F
THEOS_RS05860	COG0183	Belongs to the thiolase family
THEOS_RS05865	COG1960	acyl-CoA dehydrogenase activity
THEOS_RS05875	COG1752	Esterase of the alpha-beta hydrolase superfamily
THEOS_RS05880	COG3311	Transcriptional regulator
THEOS_RS05890	COG0134	indole-3-glycerol-phosphate synthase activity
THEOS_RS05895	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
THEOS_RS05905	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
THEOS_RS05915	COG0525	valine-tRNA ligase activity
THEOS_RS05920	COG0765	amino acid transport
THEOS_RS05925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THEOS_RS05935	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
THEOS_RS05945	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THEOS_RS05955	COG2313	pseudouridylate synthase activity
THEOS_RS05965	COG3001	Fructosamine kinase
THEOS_RS05970	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THEOS_RS05975	COG4585	Histidine kinase
THEOS_RS05980	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
THEOS_RS05985	COG4499	WXG100 protein secretion system (Wss), protein YukC
THEOS_RS05985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
THEOS_RS06000	COG0012	GTP binding
THEOS_RS06005	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
THEOS_RS06015	COG0424	maF-like protein
THEOS_RS06030	COG0768	penicillin binding
THEOS_RS06075	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
THEOS_RS06080	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
THEOS_RS06090	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
THEOS_RS06100	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THEOS_RS06110	COG4555	ABC transporter
THEOS_RS06125	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THEOS_RS06135	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
THEOS_RS06140	COG0440	acetolactate synthase activity
THEOS_RS06145	COG0028	Belongs to the TPP enzyme family
THEOS_RS06150	COG0492	ferredoxin-NADP+ reductase activity
THEOS_RS06155	COG0861	Integral membrane protein TerC family
THEOS_RS06165	COG4970	Tfp pilus assembly protein FimT
THEOS_RS06170	COG4970	Tfp pilus assembly protein FimT
THEOS_RS06175	COG2165	general secretion pathway protein
THEOS_RS06180	COG4966	pilus assembly protein PilW
THEOS_RS06190	COG2165	general secretion pathway protein
THEOS_RS06210	COG4636	protein conserved in cyanobacteria
THEOS_RS06225	COG0180	Tryptophanyl-tRNA synthetase
THEOS_RS06235	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THEOS_RS06240	COG0066	3-isopropylmalate dehydratase activity
THEOS_RS06245	COG0473	3-isopropylmalate dehydrogenase activity
THEOS_RS06260	COG1028	Short-chain dehydrogenase reductase Sdr
THEOS_RS06265	COG0129	dihydroxy-acid dehydratase activity
THEOS_RS06275	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
THEOS_RS06280	COG1177	transmembrane transport
THEOS_RS06285	COG1176	ABC-type spermidine putrescine transport system, permease component I
THEOS_RS06290	COG3842	ATPase activity
THEOS_RS06295	COG0772	Belongs to the SEDS family
THEOS_RS06300	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
THEOS_RS06305	COG2894	cell division
THEOS_RS06310	COG1733	regulation of RNA biosynthetic process
THEOS_RS06320	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
THEOS_RS06320	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
THEOS_RS06330	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THEOS_RS06335	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THEOS_RS06340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THEOS_RS06345	COG0653	protein targeting
THEOS_RS06350	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
THEOS_RS06370	COG1205	dead DEAH box helicase
THEOS_RS06370	COG1111	helicase
THEOS_RS06385	COG0358	DNA primase activity
THEOS_RS06395	COG1250	3-hydroxyacyl-CoA dehydrogenase
THEOS_RS06400	COG0697	spore germination
THEOS_RS06405	COG0612	Peptidase, M16
THEOS_RS06410	COG0612	Peptidase, M16
THEOS_RS06415	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THEOS_RS06430	COG1070	Carbohydrate kinase
THEOS_RS06470	COG0582	viral genome integration into host DNA
THEOS_RS06520	COG0582	viral genome integration into host DNA
THEOS_RS06570	COG2189	Belongs to the N(4) N(6)-methyltransferase family
THEOS_RS06590	COG0582	viral genome integration into host DNA
THEOS_RS06600	COG0052	Belongs to the universal ribosomal protein uS2 family
THEOS_RS06605	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
THEOS_RS06610	COG0528	UMP kinase activity
THEOS_RS06615	COG0233	cytoplasmic translational termination
THEOS_RS06620	COG4589	Belongs to the CDS family
THEOS_RS06625	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
THEOS_RS06645	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
THEOS_RS06650	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
THEOS_RS06655	COG2359	stage V sporulation protein S
THEOS_RS06670	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
THEOS_RS06680	COG1410	methionine synthase
THEOS_RS06680	COG0646	methionine synthase
THEOS_RS06685	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
THEOS_RS06690	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
THEOS_RS06695	COG0740	serine-type endopeptidase activity
THEOS_RS06700	COG0544	peptidyl-prolyl cis-trans isomerase activity
THEOS_RS06720	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
THEOS_RS06725	COG3870	Protein conserved in bacteria
THEOS_RS06730	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
THEOS_RS06740	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
THEOS_RS06760	COG1309	transcriptional regulator
THEOS_RS06765	COG1960	acyl-CoA dehydrogenase activity
THEOS_RS06770	COG1012	belongs to the aldehyde dehydrogenase family
THEOS_RS06770	COG2030	dehydratase
THEOS_RS06780	COG0318	PFAM AMP-dependent synthetase and ligase
THEOS_RS06785	COG1028	Short-chain dehydrogenase reductase Sdr
THEOS_RS06795	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THEOS_RS06800	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
THEOS_RS06805	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
THEOS_RS06810	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
THEOS_RS06820	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
THEOS_RS06830	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
THEOS_RS06835	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
THEOS_RS06845	COG3383	formate dehydrogenase (NAD+) activity
THEOS_RS06850	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
THEOS_RS06865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THEOS_RS06875	COG0165	Argininosuccinate lyase
THEOS_RS06900	COG1022	Amp-dependent synthetase and ligase
THEOS_RS06910	COG4475	Protein of unknown function (DUF436)
THEOS_RS06925	COG1970	mechanosensitive ion channel activity
THEOS_RS06930	COG3842	ATPase activity
THEOS_RS06935	COG0572	uridine kinase
THEOS_RS06955	COG2176	DNA-directed DNA polymerase activity
THEOS_RS06960	COG0154	amidase activity
THEOS_RS06965	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
THEOS_RS06975	COG1435	thymidine kinase activity
THEOS_RS06980	COG0254	rRNA binding
THEOS_RS06990	COG4864	UPF0365 protein
THEOS_RS07000	COG1702	phosphate starvation-inducible protein PhoH
THEOS_RS07005	COG0481	GTPase activity
THEOS_RS07015	COG1760	l-serine dehydratase
THEOS_RS07025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THEOS_RS07065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THEOS_RS07080	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
THEOS_RS07095	COG1316	TRANSCRIPTIONal
THEOS_RS07110	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
THEOS_RS07130	COG1573	uracil-dna glycosylase
THEOS_RS07145	COG3842	ATPase activity
THEOS_RS07155	COG0124	histidyl-tRNA synthetase
THEOS_RS07165	COG0384	phenazine biosynthesis protein PhzF
THEOS_RS07170	COG0561	phosphatase activity
THEOS_RS07175	COG0017	Asparaginyl-tRNA synthetase
THEOS_RS07180	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
THEOS_RS07225	COG0702	epimerase
THEOS_RS07230	COG1233	COG1233 Phytoene dehydrogenase and related
THEOS_RS07265	COG0640	Transcriptional regulator
THEOS_RS07270	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
THEOS_RS07280	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
THEOS_RS07285	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
THEOS_RS07290	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
THEOS_RS07295	COG0006	proline dipeptidase activity
THEOS_RS07300	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
THEOS_RS07305	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
THEOS_RS07310	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
THEOS_RS07315	COG1994	Peptidase M50
THEOS_RS07325	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THEOS_RS07325	COG0617	tRNA 3'-terminal CCA addition
THEOS_RS07325	COG0517	IMP dehydrogenase activity
THEOS_RS07335	COG0438	transferase activity, transferring glycosyl groups
THEOS_RS07340	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THEOS_RS07350	COG2819	hydrolase of the alpha beta superfamily
THEOS_RS07355	COG0861	Integral membrane protein TerC family
THEOS_RS07365	COG0247	lactate metabolic process
THEOS_RS07365	COG2181	nitrate reductase activity
THEOS_RS07375	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
THEOS_RS07380	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
THEOS_RS07385	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THEOS_RS07395	COG0439	Biotin carboxylase
THEOS_RS07400	COG0511	ligase activity, forming carbon-carbon bonds
THEOS_RS07405	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
THEOS_RS07420	COG0010	Belongs to the arginase family
THEOS_RS07435	COG1100	Small GTP-binding protein
THEOS_RS07445	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
THEOS_RS07450	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
THEOS_RS07460	COG2814	Major facilitator Superfamily
THEOS_RS07465	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
THEOS_RS07470	COG1185	polyribonucleotide nucleotidyltransferase activity
THEOS_RS07475	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
THEOS_RS07485	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
THEOS_RS07490	COG0745	RESPONSE REGULATOR receiver
THEOS_RS07495	COG5002	protein histidine kinase activity
THEOS_RS07500	COG1960	acyl-CoA dehydrogenase activity
THEOS_RS07505	COG2086	electron transfer activity
THEOS_RS07510	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
THEOS_RS07520	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
THEOS_RS07525	COG1573	uracil-dna glycosylase
THEOS_RS07530	COG1796	DNA polymerase
THEOS_RS07530	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
THEOS_RS07545	COG0674	pyruvate-flavodoxin oxidoreductase activity
THEOS_RS07545	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
THEOS_RS07545	COG1013	pyruvate-flavodoxin oxidoreductase activity
THEOS_RS07545	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THEOS_RS07565	COG2873	o-acetylhomoserine
THEOS_RS07575	COG0300	oxidoreductase activity
THEOS_RS07585	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
THEOS_RS07590	COG0215	cysteine-tRNA ligase activity
THEOS_RS07595	COG1960	acyl-CoA dehydrogenase activity
THEOS_RS07600	COG0183	Belongs to the thiolase family
THEOS_RS07605	COG1250	3-hydroxyacyl-CoA dehydrogenase
THEOS_RS07605	COG1024	Enoyl-CoA hydratase
THEOS_RS07625	COG0318	PFAM AMP-dependent synthetase and ligase
THEOS_RS07640	COG1063	alcohol dehydrogenase
THEOS_RS07645	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THEOS_RS07650	COG1012	belongs to the aldehyde dehydrogenase family
THEOS_RS07655	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
THEOS_RS07680	COG1216	Glycosyl transferase, family 2
THEOS_RS07690	COG1216	Glycosyl transferase, family 2
THEOS_RS07705	COG1811	Na channel or pump
THEOS_RS07710	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THEOS_RS07715	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
THEOS_RS07720	COG4948	Mandelate Racemase Muconate Lactonizing
THEOS_RS07730	COG0402	S-adenosylhomocysteine deaminase activity
THEOS_RS07745	COG1012	belongs to the aldehyde dehydrogenase family
THEOS_RS07750	COG0506	proline dehydrogenase activity
THEOS_RS07755	COG1802	Transcriptional regulator
THEOS_RS07780	COG0156	8-amino-7-oxononanoate synthase activity
THEOS_RS07795	COG0187	DNA topoisomerase II activity
THEOS_RS07800	COG1643	Atp-dependent helicase
THEOS_RS07815	COG1063	alcohol dehydrogenase
THEOS_RS07845	COG1028	Short-chain dehydrogenase reductase Sdr
THEOS_RS07870	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
THEOS_RS07870	COG1605	Chorismate mutase
THEOS_RS07875	COG0805	protein transport
THEOS_RS07880	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THEOS_RS07885	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
THEOS_RS07890	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
THEOS_RS07905	COG0686	Belongs to the AlaDH PNT family
THEOS_RS07910	COG0427	acetyl-CoA hydrolase
THEOS_RS07915	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
THEOS_RS07920	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
THEOS_RS07920	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THEOS_RS07925	COG0083	homoserine kinase activity
THEOS_RS07935	COG0268	Binds directly to 16S ribosomal RNA
THEOS_RS07945	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
THEOS_RS07965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THEOS_RS07970	COG1138	Cytochrome C-type biogenesis protein
THEOS_RS07975	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
THEOS_RS07980	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
THEOS_RS07985	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
THEOS_RS07990	COG1131	(ABC) transporter
THEOS_RS07995	COG0785	Cytochrome C biogenesis protein
THEOS_RS08005	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
THEOS_RS08010	COG0446	pyridine nucleotide-disulphide oxidoreductase
THEOS_RS08025	COG3258	Cytochrome c
THEOS_RS08030	COG2010	Cytochrome c
THEOS_RS08035	COG0737	Belongs to the 5'-nucleotidase family
THEOS_RS08040	COG2010	Cytochrome c
THEOS_RS08045	COG3258	Cytochrome c
THEOS_RS08065	COG2010	Cytochrome c
THEOS_RS08070	COG3842	ATPase activity
THEOS_RS08090	COG0516	GMP reductase activity
THEOS_RS08090	COG0517	IMP dehydrogenase activity
THEOS_RS08095	COG2814	Major facilitator Superfamily
THEOS_RS08100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THEOS_RS08115	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THEOS_RS08130	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
THEOS_RS08135	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
THEOS_RS08140	COG0107	imidazoleglycerol-phosphate synthase activity
THEOS_RS08145	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
THEOS_RS08145	COG0140	phosphoribosyl-ATP diphosphatase activity
THEOS_RS08150	COG1494	fructose-1,6-bisphosphatase
THEOS_RS08175	COG0395	ABC-type sugar transport system, permease component
THEOS_RS08180	COG1175	transmembrane transport
THEOS_RS08200	COG0084	hydrolase, TatD family'
THEOS_RS08215	COG0017	Asparaginyl-tRNA synthetase
THEOS_RS08220	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
THEOS_RS08235	COG2009	succinate dehydrogenase
THEOS_RS08240	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
THEOS_RS08270	COG0318	PFAM AMP-dependent synthetase and ligase
THEOS_RS08275	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
THEOS_RS08280	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
THEOS_RS08285	COG0504	CTP synthase activity
THEOS_RS08300	COG0067	glutamate synthase
THEOS_RS08300	COG0070	glutamate synthase
THEOS_RS08300	COG0069	glutamate synthase activity
THEOS_RS08330	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
THEOS_RS08335	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
THEOS_RS08340	COG1506	peptidase
THEOS_RS08340	COG4946	Tricorn protease homolog
THEOS_RS08340	COG0823	Involved in the tonB-independent uptake of proteins
THEOS_RS08440	COG0538	isocitrate dehydrogenase activity
THEOS_RS08445	COG0557	exoribonuclease II activity
THEOS_RS08455	COG0585	pseudouridine synthase activity
THEOS_RS08475	COG2050	protein possibly involved in aromatic compounds catabolism
THEOS_RS08480	COG0322	excinuclease ABC activity
THEOS_RS08490	COG0018	arginyl-trna synthetase
THEOS_RS08500	COG1428	Deoxynucleoside kinase
THEOS_RS08510	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THEOS_RS08525	COG2081	HI0933 family
THEOS_RS08540	COG0463	Glycosyl transferase, family 2
THEOS_RS08550	COG0745	RESPONSE REGULATOR receiver
THEOS_RS08555	COG5002	protein histidine kinase activity
THEOS_RS08570	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
THEOS_RS08580	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
THEOS_RS08585	COG0572	uridine kinase
THEOS_RS08610	COG0583	DNA-binding transcription factor activity
THEOS_RS08640	COG0191	fructose-bisphosphate aldolase activity
THEOS_RS08645	COG2045	Belongs to the ComB family
THEOS_RS08660	COG0513	Belongs to the DEAD box helicase family
THEOS_RS08665	COG0303	'Molybdopterin
THEOS_RS08700	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
THEOS_RS08705	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THEOS_RS08710	COG1028	Short-chain dehydrogenase reductase Sdr
THEOS_RS08720	COG1213	nucleotidyl transferase
THEOS_RS08720	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THEOS_RS08725	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
THEOS_RS08730	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
THEOS_RS08735	COG1104	cysteine desulfurase activity
THEOS_RS08740	COG1959	2 iron, 2 sulfur cluster binding
THEOS_RS08745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THEOS_RS08750	COG1121	(ABC) transporter
THEOS_RS08775	COG0318	PFAM AMP-dependent synthetase and ligase
THEOS_RS08795	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
THEOS_RS08800	COG0706	membrane insertase activity
THEOS_RS08805	COG1837	Belongs to the UPF0109 family
THEOS_RS08820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THEOS_RS08835	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
THEOS_RS08855	COG0318	PFAM AMP-dependent synthetase and ligase
THEOS_RS08860	COG3360	Dodecin
THEOS_RS08875	COG1024	Enoyl-CoA hydratase
THEOS_RS08880	COG0813	purine-nucleoside phosphorylase activity
THEOS_RS08885	COG1136	(ABC) transporter
THEOS_RS08890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THEOS_RS08895	COG2045	Belongs to the ComB family
THEOS_RS08905	COG0789	Transcriptional regulator
THEOS_RS08910	COG1414	Transcriptional regulator
THEOS_RS08915	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
THEOS_RS08925	COG0277	FAD linked oxidase domain protein
THEOS_RS08930	COG0277	FAD linked oxidase domain protein
THEOS_RS08935	COG0247	lactate metabolic process
THEOS_RS08955	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THEOS_RS09000	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
THEOS_RS09005	COG0460	homoserine dehydrogenase
THEOS_RS09010	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
THEOS_RS09030	COG2226	methyltransferase
THEOS_RS09035	COG2226	methyltransferase
THEOS_RS09040	COG0366	Alpha amylase catalytic
THEOS_RS09050	COG0037	tRNA processing
THEOS_RS09055	COG2104	thiamine diphosphate biosynthetic process
THEOS_RS09060	COG0123	including yeast histone deacetylase and acetoin utilization protein
THEOS_RS09065	COG0517	IMP dehydrogenase activity
THEOS_RS09075	COG0444	Belongs to the ABC transporter superfamily
THEOS_RS09080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THEOS_RS09085	COG0601	transmembrane transport
THEOS_RS09090	COG0747	negative chemotaxis
THEOS_RS09100	COG0492	ferredoxin-NADP+ reductase activity
THEOS_RS09155	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THEOS_RS09165	COG2414	aldehyde ferredoxin oxidoreductase
THEOS_RS09200	COG1902	pentaerythritol trinitrate reductase activity
THEOS_RS09215	COG0495	leucyl-tRNA aminoacylation
THEOS_RS09220	COG0539	negative regulation of cytoplasmic translation
THEOS_RS09220	COG2183	response to ionizing radiation
THEOS_RS09235	COG1694	Mazg nucleotide pyrophosphohydrolase
THEOS_RS09240	COG1803	Methylglyoxal synthase
THEOS_RS09245	COG0154	amidase activity
THEOS_RS09270	COG0667	Aldo Keto reductase
THEOS_RS09285	COG1067	ATP-dependent peptidase activity
THEOS_RS09290	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
THEOS_RS09300	COG0745	RESPONSE REGULATOR receiver
THEOS_RS09310	COG0297	glycogen (starch) synthase activity
THEOS_RS09320	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
THEOS_RS09325	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
THEOS_RS09345	COG0697	spore germination
THEOS_RS09350	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
THEOS_RS09400	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
THEOS_RS09405	COG2860	membrane
THEOS_RS09410	COG0315	cyclic pyranopterin monophosphate synthase activity
THEOS_RS09445	COG0735	belongs to the Fur family
THEOS_RS09450	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
THEOS_RS09455	COG3872	metal-dependent enzyme
THEOS_RS09460	COG0482	sulfurtransferase activity
THEOS_RS09465	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
THEOS_RS09470	COG0573	inorganic phosphate transmembrane transporter activity
THEOS_RS09480	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THEOS_RS09485	COG2814	Major facilitator Superfamily
THEOS_RS09490	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THEOS_RS09500	COG1388	LysM domain
THEOS_RS09500	COG0791	NLP P60 protein
THEOS_RS09505	COG0778	Nitroreductase
THEOS_RS09510	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
THEOS_RS09515	COG1960	acyl-CoA dehydrogenase activity
THEOS_RS09520	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THEOS_RS09530	COG0445	tRNA wobble uridine modification
THEOS_RS09550	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THEOS_RS09555	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THEOS_RS09555	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THEOS_RS09560	COG1543	Belongs to the glycosyl hydrolase 57 family
THEOS_RS09565	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THEOS_RS09570	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
THEOS_RS09575	COG0189	ligase activity
THEOS_RS09590	COG0066	3-isopropylmalate dehydratase activity
THEOS_RS09595	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THEOS_RS09610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THEOS_RS09615	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
THEOS_RS09620	COG1960	acyl-CoA dehydrogenase activity
THEOS_RS09625	COG0163	prenyltransferase activity
THEOS_RS09630	COG0222	ribosome binding
THEOS_RS09635	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
THEOS_RS09640	COG0081	regulation of translation
THEOS_RS09650	COG0250	Participates in transcription elongation, termination and antitermination
THEOS_RS09655	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THEOS_RS09660	COG0267	Belongs to the bacterial ribosomal protein bL33 family
THEOS_RS09690	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
THEOS_RS09695	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THEOS_RS09700	COG1335	isochorismatase
THEOS_RS09705	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
THEOS_RS09715	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
THEOS_RS09725	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
THEOS_RS09730	COG1993	acr, cog1993
THEOS_RS09735	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THEOS_RS09740	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
THEOS_RS09750	COG1496	oxidoreductase activity
THEOS_RS09755	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
THEOS_RS09760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THEOS_RS09770	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THEOS_RS09800	COG1842	Phage shock protein A
THEOS_RS09820	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THEOS_RS09825	COG1774	PSP1 C-terminal conserved region
THEOS_RS09835	COG1079	Belongs to the binding-protein-dependent transport system permease family
THEOS_RS09840	COG4603	Belongs to the binding-protein-dependent transport system permease family
THEOS_RS09845	COG2226	methyltransferase
THEOS_RS09850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THEOS_RS09870	COG0512	Glutamine amidotransferase of anthranilate synthase
THEOS_RS09875	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
THEOS_RS09880	COG2010	Cytochrome c
THEOS_RS09885	COG0535	radical SAM domain protein
THEOS_RS09900	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
THEOS_RS09920	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THEOS_RS09945	COG1597	lipid kinase activity
THEOS_RS09950	COG0406	alpha-ribazole phosphatase activity
THEOS_RS09960	COG0123	including yeast histone deacetylase and acetoin utilization protein
THEOS_RS09970	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
THEOS_RS09980	COG0004	ammonium transporteR
THEOS_RS09985	COG0347	Belongs to the P(II) protein family
THEOS_RS09990	COG1420	regulation of RNA biosynthetic process
THEOS_RS09995	COG0314	molybdopterin synthase activity
THEOS_RS10010	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
THEOS_RS10015	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THEOS_RS10025	COG2154	pterin-4-alpha-carbinolamine dehydratase
THEOS_RS10030	COG1607	acyl-coa hydrolase
THEOS_RS10040	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
THEOS_RS10045	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
THEOS_RS10050	COG1185	polyribonucleotide nucleotidyltransferase activity
THEOS_RS10060	COG0416	fatty acid biosynthetic process
THEOS_RS10065	COG1371	PFAM Archease protein family (DUF101 UPF0211)
THEOS_RS10070	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
THEOS_RS10090	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
THEOS_RS10095	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
THEOS_RS10115	COG2096	Adenosyltransferase
THEOS_RS10125	COG4555	ABC transporter
THEOS_RS10150	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THEOS_RS10165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
THEOS_RS10170	COG3706	GGDEF domain
THEOS_RS10205	COG0437	4 iron, 4 sulfur cluster binding
THEOS_RS10220	COG0802	atpase or kinase
THEOS_RS10225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THEOS_RS10230	COG2389	metal-binding protein
THEOS_RS10235	COG4242	Belongs to the peptidase S51 family
THEOS_RS10240	COG1309	transcriptional regulator
THEOS_RS10255	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
THEOS_RS10260	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
THEOS_RS10265	COG1968	undecaprenyl-diphosphatase activity
THEOS_RS10270	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
THEOS_RS10275	COG0484	heat shock protein binding
THEOS_RS10280	COG1278	Cold shock
THEOS_RS10290	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
THEOS_RS10325	COG0358	DNA primase activity
THEOS_RS10360	COG0321	lipoyl(octanoyl) transferase activity
THEOS_RS10365	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
THEOS_RS10380	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THEOS_RS10395	COG1598	PFAM Uncharacterised protein family UPF0150
THEOS_RS10400	COG0022	dehydrogenase e1 component
THEOS_RS10405	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
THEOS_RS10410	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
THEOS_RS10445	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
THEOS_RS10455	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
THEOS_RS10460	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
THEOS_RS10465	COG1187	pseudouridine synthase activity
THEOS_RS10470	COG1024	Enoyl-CoA hydratase
THEOS_RS10475	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
THEOS_RS10480	COG0686	Belongs to the AlaDH PNT family
THEOS_RS10485	COG1302	Protein conserved in bacteria
THEOS_RS10490	COG1461	Dihydroxyacetone kinase
THEOS_RS10510	COG0359	binds to the 23S rRNA
THEOS_RS10515	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
THEOS_RS10540	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
THEOS_RS10570	COG0243	molybdopterin cofactor binding
THEOS_RS10580	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
THEOS_RS10590	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
THEOS_RS10605	COG0477	Major facilitator Superfamily
THEOS_RS10620	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
THEOS_RS10685	COG0105	UTP biosynthetic process
THEOS_RS10690	COG0631	protein serine/threonine phosphatase activity
THEOS_RS10695	COG0583	DNA-binding transcription factor activity
THEOS_RS10700	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
THEOS_RS10705	COG0508	dehydrogenase complex catalyzes the overall conversion of
THEOS_RS10710	COG1653	transport
THEOS_RS10740	COG2223	nitrite transmembrane transporter activity
THEOS_RS10750	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
THEOS_RS10750	COG0517	IMP dehydrogenase activity
THEOS_RS10755	COG1950	PFAM Membrane protein of
THEOS_RS10760	COG1309	transcriptional regulator
THEOS_RS10765	COG1131	(ABC) transporter
THEOS_RS10770	COG0842	Transport permease protein
THEOS_RS10785	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
THEOS_RS10795	COG1278	Cold shock
THEOS_RS10800	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
THEOS_RS10820	COG0521	Mo-molybdopterin cofactor biosynthetic process
THEOS_RS10825	COG0436	Aminotransferase
THEOS_RS10830	COG0285	dihydrofolate synthase activity
THEOS_RS10835	COG0735	belongs to the Fur family
THEOS_RS10840	COG0181	hydroxymethylbilane synthase activity
THEOS_RS10870	COG0072	phenylalanine-tRNA ligase activity
THEOS_RS10870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THEOS_RS10880	COG0205	6-phosphofructokinase activity
THEOS_RS10885	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
THEOS_RS10895	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
THEOS_RS10915	COG0658	competence protein
THEOS_RS10915	COG2333	competence protein COMEC
THEOS_RS10920	COG1475	DNA binding
THEOS_RS10925	COG1192	Involved in chromosome partitioning
THEOS_RS10930	COG0357	Ribosomal RNA small subunit methyltransferase G
THEOS_RS10935	COG0445	tRNA wobble uridine modification
THEOS_RS11470	COG0505	Belongs to the CarA family
THEOS_RS11715	COG0497	DNA recombination
THEOS_RS11745	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THEOS_RS11760	COG2205	protein histidine kinase activity
THEOS_RS11930	COG0343	queuine tRNA-ribosyltransferase activity
THEOS_RS12270	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THEOS_RS12410	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THEOS_RS12510	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
THEOS_RS12525	COG1612	heme a metabolic process
THEOS_RS12525	COG0109	protoheme IX farnesyltransferase activity
THEOS_RS12545	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
THEOS_RS12545	COG1845	cytochrome c oxidase, subunit III
THEOS_RS12630	COG0582	viral genome integration into host DNA
THEOS_RS12660	COG1116	anion transmembrane transporter activity
THEOS_RS12665	COG0442	prolyl-tRNA aminoacylation