locus-tag	class	description
AV541_RS00035	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AV541_RS00040	COG0022	dehydrogenase e1 component
AV541_RS00050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AV541_RS00105	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AV541_RS00110	COG0321	lipoyl(octanoyl) transferase activity
AV541_RS00115	COG0300	oxidoreductase activity
AV541_RS00125	COG0359	binds to the 23S rRNA
AV541_RS00130	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AV541_RS00135	COG0629	single-stranded DNA binding
AV541_RS00150	COG0081	regulation of translation
AV541_RS00160	COG0250	Participates in transcription elongation, termination and antitermination
AV541_RS00165	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AV541_RS00170	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AV541_RS00175	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AV541_RS00200	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AV541_RS00215	COG0735	belongs to the Fur family
AV541_RS00220	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AV541_RS00230	COG0482	sulfurtransferase activity
AV541_RS00235	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AV541_RS00240	COG0573	inorganic phosphate transmembrane transporter activity
AV541_RS00250	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AV541_RS00255	COG2814	Major facilitator Superfamily
AV541_RS00270	COG3103	Sh3 type 3 domain protein
AV541_RS00270	COG1388	LysM domain
AV541_RS00270	COG0791	NLP P60 protein
AV541_RS00295	COG0459	protein refolding
AV541_RS00300	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AV541_RS00305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AV541_RS00320	COG0714	Associated with various cellular activities
AV541_RS00330	COG0166	Belongs to the GPI family
AV541_RS00365	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AV541_RS00365	COG0165	Argininosuccinate lyase
AV541_RS00370	COG0165	Argininosuccinate lyase
AV541_RS00385	COG1404	Belongs to the peptidase S8 family
AV541_RS00395	COG0508	dehydrogenase complex catalyzes the overall conversion of
AV541_RS00405	COG1024	Enoyl-CoA hydratase
AV541_RS00410	COG0632	four-way junction helicase activity
AV541_RS00415	COG1011	Hydrolase
AV541_RS00425	COG1611	Belongs to the LOG family
AV541_RS00430	COG0589	response to stress
AV541_RS00435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AV541_RS00440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AV541_RS00450	COG1940	carbohydrate kinase activity
AV541_RS00480	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AV541_RS00500	COG1612	heme a metabolic process
AV541_RS00500	COG0109	protoheme IX farnesyltransferase activity
AV541_RS00505	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AV541_RS00505	COG2010	Cytochrome c
AV541_RS00575	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AV541_RS00605	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AV541_RS00625	COG1335	isochorismatase
AV541_RS00630	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AV541_RS00640	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AV541_RS00650	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AV541_RS00655	COG1993	acr, cog1993
AV541_RS00665	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AV541_RS00720	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AV541_RS00725	COG1950	PFAM Membrane protein of
AV541_RS00730	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AV541_RS00730	COG0517	IMP dehydrogenase activity
AV541_RS00740	COG2814	Major facilitator Superfamily
AV541_RS00755	COG0033	Phosphoglucomutase
AV541_RS00770	COG1653	transport
AV541_RS00785	COG1278	Cold shock
AV541_RS00790	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AV541_RS00795	COG1496	oxidoreductase activity
AV541_RS00815	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AV541_RS00820	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AV541_RS00825	COG0406	alpha-ribazole phosphatase activity
AV541_RS00865	COG1842	Phage shock protein A
AV541_RS00895	COG2010	Cytochrome c
AV541_RS00900	COG0469	pyruvate kinase activity
AV541_RS00910	COG0592	DNA-directed DNA polymerase activity
AV541_RS00915	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AV541_RS00925	COG0357	Ribosomal RNA small subunit methyltransferase G
AV541_RS00930	COG1192	Involved in chromosome partitioning
AV541_RS00945	COG1555	photosystem II stabilization
AV541_RS00960	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AV541_RS00970	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AV541_RS00975	COG0205	6-phosphofructokinase activity
AV541_RS00995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AV541_RS01000	COG1013	pyruvate-flavodoxin oxidoreductase activity
AV541_RS01005	COG0674	pyruvate-flavodoxin oxidoreductase activity
AV541_RS01005	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AV541_RS01015	COG1937	Protein conserved in bacteria
AV541_RS01030	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AV541_RS01035	COG0693	protein deglycase activity
AV541_RS01045	COG3956	TIGRFAM MazG family protein
AV541_RS01055	COG0393	Putative heavy-metal-binding
AV541_RS01075	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AV541_RS01085	COG1960	acyl-CoA dehydrogenase activity
AV541_RS01090	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AV541_RS01105	COG2010	Cytochrome c
AV541_RS01115	COG0723	plastoquinol--plastocyanin reductase activity
AV541_RS01120	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AV541_RS01130	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AV541_RS01135	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AV541_RS01155	COG2096	Adenosyltransferase
AV541_RS01165	COG4555	ABC transporter
AV541_RS01210	COG0163	prenyltransferase activity
AV541_RS01220	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AV541_RS01225	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AV541_RS01240	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AV541_RS01245	COG0066	3-isopropylmalate dehydratase activity
AV541_RS01265	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AV541_RS01270	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AV541_RS01280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AV541_RS01280	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AV541_RS01300	COG0445	tRNA wobble uridine modification
AV541_RS01310	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AV541_RS01315	COG0497	DNA recombination
AV541_RS01320	COG0556	nucleotide-excision repair
AV541_RS01330	COG2309	aminopeptidase activity
AV541_RS01340	COG1131	(ABC) transporter
AV541_RS01350	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AV541_RS01355	COG0395	ABC-type sugar transport system, permease component
AV541_RS01365	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AV541_RS01390	COG0302	gtp cyclohydrolase
AV541_RS01405	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AV541_RS01435	COG0470	DNA polymerase III
AV541_RS01465	COG2226	methyltransferase
AV541_RS01470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AV541_RS01500	COG0512	Glutamine amidotransferase of anthranilate synthase
AV541_RS01525	COG0396	ATPase activity
AV541_RS01540	COG0446	pyridine nucleotide-disulphide oxidoreductase
AV541_RS01545	COG4181	ATPase activity
AV541_RS01560	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AV541_RS01570	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AV541_RS01580	COG1175	transmembrane transport
AV541_RS01595	COG4948	Mandelate Racemase Muconate Lactonizing
AV541_RS01610	COG0354	folic acid binding
AV541_RS01615	COG1058	Belongs to the CinA family
AV541_RS01615	COG1546	Belongs to the CinA family
AV541_RS01620	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AV541_RS01625	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AV541_RS01630	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AV541_RS01630	COG1418	mRNA catabolic process
AV541_RS01635	COG1077	Cell shape determining protein MreB Mrl
AV541_RS01640	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AV541_RS01655	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AV541_RS01660	COG0235	Class ii aldolase
AV541_RS01675	COG1840	ABC-type Fe3 transport system, periplasmic component
AV541_RS01685	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AV541_RS01695	COG1607	acyl-coa hydrolase
AV541_RS01700	COG2154	pterin-4-alpha-carbinolamine dehydratase
AV541_RS01715	COG0154	amidase activity
AV541_RS01730	COG1803	Methylglyoxal synthase
AV541_RS01735	COG1694	Mazg nucleotide pyrophosphohydrolase
AV541_RS01755	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AV541_RS01760	COG2860	membrane
AV541_RS01765	COG0315	cyclic pyranopterin monophosphate synthase activity
AV541_RS01830	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AV541_RS01835	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AV541_RS01845	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AV541_RS01870	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AV541_RS01905	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AV541_RS01910	COG0825	malonyl-CoA metabolic process
AV541_RS02000	COG0438	transferase activity, transferring glycosyl groups
AV541_RS02010	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AV541_RS02020	COG3118	belongs to the thioredoxin family
AV541_RS02025	COG0416	fatty acid biosynthetic process
AV541_RS02035	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AV541_RS02045	COG0284	orotidine-5'-phosphate decarboxylase activity
AV541_RS02050	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AV541_RS02060	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AV541_RS02080	COG0822	iron-sulfur transferase activity
AV541_RS02085	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AV541_RS02095	COG2132	Multicopper oxidase
AV541_RS02135	COG2205	protein histidine kinase activity
AV541_RS02140	COG0745	RESPONSE REGULATOR receiver
AV541_RS02165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AV541_RS02175	COG0668	transmembrane transport
AV541_RS02180	COG3253	May function as heme-dependent peroxidase
AV541_RS02185	COG0432	Pfam Uncharacterised protein family UPF0047
AV541_RS02230	COG1489	DNA binding
AV541_RS02250	COG1115	amino acid carrier protein
AV541_RS02260	COG0442	prolyl-tRNA aminoacylation
AV541_RS02280	COG0049	tRNA binding
AV541_RS02290	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AV541_RS02295	COG0051	transcription antitermination factor activity, RNA binding
AV541_RS02305	COG0088	Forms part of the polypeptide exit tunnel
AV541_RS02310	COG0089	rRNA binding
AV541_RS02315	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AV541_RS02320	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AV541_RS02330	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AV541_RS02335	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AV541_RS02340	COG0255	Belongs to the universal ribosomal protein uL29 family
AV541_RS02365	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AV541_RS02370	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AV541_RS02375	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AV541_RS02400	COG0201	protein transport
AV541_RS02405	COG0563	adenylate kinase activity
AV541_RS02415	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AV541_RS02425	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AV541_RS02430	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AV541_RS02435	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AV541_RS02440	COG0202	RNA polymerase activity
AV541_RS02445	COG0203	ribosomal protein L17
AV541_RS02475	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AV541_RS02485	COG0142	geranyltranstransferase activity
AV541_RS02490	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AV541_RS02505	COG1175	transmembrane transport
AV541_RS02530	COG1611	Belongs to the LOG family
AV541_RS02535	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AV541_RS02540	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AV541_RS02550	COG1166	arginine decarboxylase activity
AV541_RS02565	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AV541_RS02570	COG0006	proline dipeptidase activity
AV541_RS02575	COG0316	Belongs to the HesB IscA family
AV541_RS02585	COG0601	transmembrane transport
AV541_RS02590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AV541_RS02595	COG0101	tRNA pseudouridine synthase activity
AV541_RS02610	COG1840	ABC-type Fe3 transport system, periplasmic component
AV541_RS02625	COG1764	response to oxidative stress
AV541_RS02635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AV541_RS02650	COG0071	Belongs to the small heat shock protein (HSP20) family
AV541_RS02655	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AV541_RS02660	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AV541_RS02675	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AV541_RS02680	COG0537	adenosine 5'-monophosphoramidase activity
AV541_RS02705	COG1011	Hydrolase
AV541_RS02710	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AV541_RS02730	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AV541_RS02765	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AV541_RS02770	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AV541_RS02775	COG0113	porphobilinogen synthase activity
AV541_RS02790	COG0631	protein serine/threonine phosphatase activity
AV541_RS02800	COG0745	RESPONSE REGULATOR receiver
AV541_RS02810	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AV541_RS02815	COG0193	aminoacyl-tRNA hydrolase activity
AV541_RS02825	COG0187	DNA topoisomerase II activity
AV541_RS02840	COG0732	type I restriction modification DNA specificity domain
AV541_RS02840	COG0827	DNA restriction-modification system
AV541_RS02845	COG0156	8-amino-7-oxononanoate synthase activity
AV541_RS02870	COG0506	proline dehydrogenase activity
AV541_RS02880	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AV541_RS02915	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AV541_RS02930	COG2385	sporulation resulting in formation of a cellular spore
AV541_RS02945	COG0194	GDP metabolic process
AV541_RS02950	COG1758	RNA polymerase activity
AV541_RS02955	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AV541_RS02960	COG1438	arginine binding
AV541_RS02965	COG2095	MarC family integral membrane protein
AV541_RS02975	COG0328	RNA-DNA hybrid ribonuclease activity
AV541_RS02985	COG4274	PFAM GYD family protein
AV541_RS02990	COG4636	protein conserved in cyanobacteria
AV541_RS02995	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AV541_RS02995	COG0519	Catalyzes the synthesis of GMP from XMP
AV541_RS03015	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AV541_RS03020	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AV541_RS03035	COG2050	protein possibly involved in aromatic compounds catabolism
AV541_RS03075	COG0538	isocitrate dehydrogenase activity
AV541_RS03095	COG0585	pseudouridine synthase activity
AV541_RS03115	COG0604	alcohol dehydrogenase
AV541_RS03155	COG0047	phosphoribosylformylglycinamidine synthase activity
AV541_RS03165	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AV541_RS03210	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AV541_RS03245	COG1272	protein, Hemolysin III
AV541_RS03255	COG0714	Associated with various cellular activities
AV541_RS03260	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AV541_RS03265	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
AV541_RS03280	COG0616	signal peptide processing
AV541_RS03290	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AV541_RS03300	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AV541_RS03310	COG0789	Transcriptional regulator
AV541_RS03345	COG0450	alkyl hydroperoxide reductase
AV541_RS03355	COG3118	belongs to the thioredoxin family
AV541_RS03375	COG0490	domain, Protein
AV541_RS03380	COG0475	glutathione-regulated potassium exporter activity
AV541_RS03395	COG0617	tRNA 3'-terminal CCA addition
AV541_RS03395	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AV541_RS03395	COG0517	IMP dehydrogenase activity
AV541_RS03415	COG0840	transmembrane signaling receptor activity
AV541_RS03420	COG0067	glutamate synthase
AV541_RS03420	COG0069	glutamate synthase activity
AV541_RS03420	COG0070	glutamate synthase
AV541_RS03455	COG0504	CTP synthase activity
AV541_RS03460	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AV541_RS03465	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AV541_RS03500	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AV541_RS03505	COG2009	succinate dehydrogenase
AV541_RS03520	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AV541_RS03530	COG0017	Asparaginyl-tRNA synthetase
AV541_RS03545	COG0084	hydrolase, TatD family'
AV541_RS03550	COG0427	acetyl-CoA hydrolase
AV541_RS03555	COG0686	Belongs to the AlaDH PNT family
AV541_RS03565	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AV541_RS03565	COG0140	phosphoribosyl-ATP diphosphatase activity
AV541_RS03570	COG0107	imidazoleglycerol-phosphate synthase activity
AV541_RS03595	COG2045	Belongs to the ComB family
AV541_RS03600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AV541_RS03610	COG0813	purine-nucleoside phosphorylase activity
AV541_RS03615	COG1024	Enoyl-CoA hydratase
AV541_RS03630	COG3360	Dodecin
AV541_RS03635	COG0318	PFAM AMP-dependent synthetase and ligase
AV541_RS03670	COG2010	Cytochrome c
AV541_RS03680	COG0785	Cytochrome C biogenesis protein
AV541_RS03685	COG4133	protoheme IX ABC transporter activity
AV541_RS03695	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AV541_RS03700	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AV541_RS03710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AV541_RS03740	COG0268	Binds directly to 16S ribosomal RNA
AV541_RS03755	COG0083	homoserine kinase activity
AV541_RS03770	COG1160	GTP binding
AV541_RS03785	COG0736	holo-[acyl-carrier-protein] synthase activity
AV541_RS03795	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AV541_RS03800	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AV541_RS03805	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AV541_RS03810	COG1450	Type ii and iii secretion system protein
AV541_RS03835	COG0473	3-isopropylmalate dehydrogenase activity
AV541_RS03865	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AV541_RS03875	COG0860	N-Acetylmuramoyl-L-alanine amidase
AV541_RS03890	COG1752	Esterase of the alpha-beta hydrolase superfamily
AV541_RS03905	COG1139	Iron-sulfur cluster binding protein
AV541_RS03910	COG0247	lactate metabolic process
AV541_RS03945	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AV541_RS03960	COG1324	tolerance protein
AV541_RS03970	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AV541_RS03975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AV541_RS03980	COG2197	response regulator
AV541_RS03995	COG0776	regulation of translation
AV541_RS04005	COG1515	deoxyribonuclease V activity
AV541_RS04015	COG1482	cell wall glycoprotein biosynthetic process
AV541_RS04025	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AV541_RS04030	COG0372	Belongs to the citrate synthase family
AV541_RS04040	COG1132	(ABC) transporter
AV541_RS04045	COG0285	dihydrofolate synthase activity
AV541_RS04055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AV541_RS04060	COG0601	transmembrane transport
AV541_RS04080	COG0559	Belongs to the binding-protein-dependent transport system permease family
AV541_RS04090	COG0174	glutamine synthetase
AV541_RS04095	COG0737	Belongs to the 5'-nucleotidase family
AV541_RS04105	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AV541_RS04110	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AV541_RS04115	COG0788	formyltetrahydrofolate deformylase activity
AV541_RS04135	COG2358	TRAP transporter, solute receptor (TAXI family
AV541_RS04160	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AV541_RS04165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AV541_RS04170	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AV541_RS04190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AV541_RS04205	COG0746	molybdenum cofactor guanylyltransferase activity
AV541_RS04210	COG1129	ABC transporter
AV541_RS04220	COG1079	Belongs to the binding-protein-dependent transport system permease family
AV541_RS04230	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AV541_RS04235	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AV541_RS04240	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AV541_RS04240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AV541_RS04245	COG0793	Belongs to the peptidase S41A family
AV541_RS04255	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AV541_RS04305	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AV541_RS04330	COG1269	ATP hydrolysis coupled proton transport
AV541_RS04340	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
AV541_RS04345	COG1527	subunit (C
AV541_RS04350	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
AV541_RS04355	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
AV541_RS04360	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
AV541_RS04365	COG1394	ATPase activity, coupled to movement of substances
AV541_RS04385	COG0612	Peptidase, M16
AV541_RS04390	COG0612	Peptidase, M16
AV541_RS04400	COG1250	3-hydroxyacyl-CoA dehydrogenase
AV541_RS04410	COG0358	DNA primase activity
AV541_RS04425	COG1111	helicase
AV541_RS04425	COG1205	dead DEAH box helicase
AV541_RS04430	COG0393	Putative heavy-metal-binding
AV541_RS04490	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AV541_RS04490	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AV541_RS04500	COG1733	regulation of RNA biosynthetic process
AV541_RS04505	COG2894	cell division
AV541_RS04510	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AV541_RS04520	COG3842	ATPase activity
AV541_RS04525	COG1176	ABC-type spermidine putrescine transport system, permease component I
AV541_RS04530	COG1177	transmembrane transport
AV541_RS04535	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AV541_RS04550	COG0300	oxidoreductase activity
AV541_RS04570	COG0066	3-isopropylmalate dehydratase activity
AV541_RS04580	COG0544	peptidyl-prolyl cis-trans isomerase activity
AV541_RS04610	COG4636	protein conserved in cyanobacteria
AV541_RS04625	COG2165	general secretion pathway protein
AV541_RS04650	COG4970	Tfp pilus assembly protein FimT
AV541_RS04655	COG0492	ferredoxin-NADP+ reductase activity
AV541_RS04660	COG0028	Belongs to the TPP enzyme family
AV541_RS04665	COG0440	acetolactate synthase activity
AV541_RS04670	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AV541_RS04680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AV541_RS04695	COG4555	ABC transporter
AV541_RS04745	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AV541_RS04755	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AV541_RS04760	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AV541_RS04805	COG0424	maF-like protein
AV541_RS04815	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AV541_RS04820	COG0012	GTP binding
AV541_RS04850	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AV541_RS04860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AV541_RS04865	COG3001	Fructosamine kinase
AV541_RS04875	COG2313	pseudouridylate synthase activity
AV541_RS04880	COG1426	Protein conserved in bacteria
AV541_RS04885	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AV541_RS04890	COG0569	domain protein
AV541_RS04905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AV541_RS04910	COG0765	amino acid transport
AV541_RS04935	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AV541_RS04940	COG0134	indole-3-glycerol-phosphate synthase activity
AV541_RS04950	COG3311	Transcriptional regulator
AV541_RS04955	COG1752	Esterase of the alpha-beta hydrolase superfamily
AV541_RS04975	COG2358	TRAP transporter, solute receptor (TAXI family
AV541_RS04980	COG2873	o-acetylhomoserine
AV541_RS05000	COG2309	aminopeptidase activity
AV541_RS05015	COG1573	uracil-dna glycosylase
AV541_RS05020	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AV541_RS05035	COG2086	electron transfer activity
AV541_RS05040	COG1960	acyl-CoA dehydrogenase activity
AV541_RS05050	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AV541_RS05055	COG1185	polyribonucleotide nucleotidyltransferase activity
AV541_RS05060	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AV541_RS05065	COG2814	Major facilitator Superfamily
AV541_RS05075	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AV541_RS05080	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AV541_RS05090	COG1100	Small GTP-binding protein
AV541_RS05105	COG0010	Belongs to the arginase family
AV541_RS05135	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AV541_RS05145	COG0439	Biotin carboxylase
AV541_RS05155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AV541_RS05160	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AV541_RS05165	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AV541_RS05175	COG2181	nitrate reductase activity
AV541_RS05175	COG0247	lactate metabolic process
AV541_RS05190	COG2819	hydrolase of the alpha beta superfamily
AV541_RS05195	COG0039	L-malate dehydrogenase activity
AV541_RS05205	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AV541_RS05210	COG0438	transferase activity, transferring glycosyl groups
AV541_RS05265	COG1744	ABC transporter substrate-binding protein PnrA-like
AV541_RS05270	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AV541_RS05275	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AV541_RS05280	COG0133	tryptophan synthase activity
AV541_RS05285	COG0159	tryptophan synthase activity
AV541_RS05305	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AV541_RS05325	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AV541_RS05345	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AV541_RS05350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AV541_RS05375	COG0275	rRNA processing
AV541_RS05395	COG0254	rRNA binding
AV541_RS05400	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AV541_RS05410	COG0739	heme binding
AV541_RS05420	COG0006	proline dipeptidase activity
AV541_RS05425	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AV541_RS05430	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AV541_RS05435	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AV541_RS05440	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AV541_RS05440	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AV541_RS05450	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AV541_RS05450	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AV541_RS05460	COG2239	Acts as a magnesium transporter
AV541_RS05465	COG1397	ADP-ribosylglycohydrolase
AV541_RS05470	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AV541_RS05480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AV541_RS05505	COG4864	UPF0365 protein
AV541_RS05520	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AV541_RS05525	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AV541_RS05535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AV541_RS05545	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AV541_RS05550	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AV541_RS05550	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AV541_RS05555	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AV541_RS05570	COG0228	four-way junction DNA binding
AV541_RS05575	COG1837	Belongs to the UPF0109 family
AV541_RS05580	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AV541_RS05585	COG0336	Belongs to the RNA methyltransferase TrmD family
AV541_RS05590	COG0335	large ribosomal subunit rRNA binding
AV541_RS05595	COG2197	response regulator
AV541_RS05605	COG2897	thiosulfate sulfurtransferase activity
AV541_RS05630	COG1309	transcriptional regulator
AV541_RS05635	COG0577	efflux transmembrane transporter activity
AV541_RS05635	COG1136	(ABC) transporter
AV541_RS05640	COG1136	(ABC) transporter
AV541_RS05645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AV541_RS05665	COG0745	RESPONSE REGULATOR receiver
AV541_RS05685	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AV541_RS05690	COG1012	belongs to the aldehyde dehydrogenase family
AV541_RS05695	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AV541_RS05695	COG2199	diguanylate cyclase activity
AV541_RS05720	COG1846	Transcriptional regulator
AV541_RS05735	COG0183	Belongs to the thiolase family
AV541_RS05750	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AV541_RS05755	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AV541_RS05765	COG1733	regulation of RNA biosynthetic process
AV541_RS05770	COG1980	fructose-bisphosphate aldolase activity
AV541_RS05790	COG4974	Belongs to the 'phage' integrase family
AV541_RS05795	COG1309	transcriptional regulator
AV541_RS05800	COG3396	Phenylacetate-CoA oxygenase
AV541_RS05860	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AV541_RS05865	COG2050	protein possibly involved in aromatic compounds catabolism
AV541_RS05900	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AV541_RS05905	COG2368	4-hydroxyphenylacetate
AV541_RS05910	COG1012	belongs to the aldehyde dehydrogenase family
AV541_RS05920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AV541_RS05930	COG3769	mannosylglycerate metabolic process
AV541_RS05945	COG1136	(ABC) transporter
AV541_RS05955	COG1307	EDD domain protein, DegV family
AV541_RS05960	COG1307	EDD domain protein, DegV family
AV541_RS05970	COG3239	Fatty acid desaturase
AV541_RS05975	COG0149	triose-phosphate isomerase activity
AV541_RS06115	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AV541_RS06125	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AV541_RS06130	COG0138	bifunctional purine biosynthesis protein purh
AV541_RS06135	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AV541_RS06140	COG0742	ribosomal rna small subunit methyltransferase
AV541_RS06155	COG0237	dephospho-CoA kinase activity
AV541_RS06160	COG0617	tRNA 3'-terminal CCA addition
AV541_RS06160	COG1353	crispr-associated protein
AV541_RS06165	COG1355	regulation of microtubule-based process
AV541_RS06170	COG0557	exoribonuclease II activity
AV541_RS06185	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AV541_RS06190	COG0126	phosphoglycerate kinase activity
AV541_RS06210	COG3153	acetyltransferase
AV541_RS06210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AV541_RS06215	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AV541_RS06250	COG2738	Putative neutral zinc metallopeptidase
AV541_RS06260	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AV541_RS06265	COG0215	cysteine-tRNA ligase activity
AV541_RS06270	COG1960	acyl-CoA dehydrogenase activity
AV541_RS06275	COG0183	Belongs to the thiolase family
AV541_RS06280	COG1250	3-hydroxyacyl-CoA dehydrogenase
AV541_RS06280	COG1024	Enoyl-CoA hydratase
AV541_RS06295	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AV541_RS06300	COG0438	transferase activity, transferring glycosyl groups
AV541_RS06315	COG1215	transferase activity, transferring glycosyl groups
AV541_RS06335	COG1811	Na channel or pump
AV541_RS06340	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AV541_RS06345	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AV541_RS06350	COG4948	Mandelate Racemase Muconate Lactonizing
AV541_RS06395	COG0494	nUDIX hydrolase
AV541_RS06400	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AV541_RS06410	COG0052	Belongs to the universal ribosomal protein uS2 family
AV541_RS06415	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AV541_RS06420	COG0528	UMP kinase activity
AV541_RS06425	COG0233	cytoplasmic translational termination
AV541_RS06430	COG0575	Belongs to the CDS family
AV541_RS06435	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AV541_RS06440	COG0750	zinc metalloprotease
AV541_RS06445	COG0463	Glycosyl transferase, family 2
AV541_RS06455	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AV541_RS06460	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AV541_RS06465	COG2359	stage V sporulation protein S
AV541_RS06475	COG2137	regulation of response to DNA damage stimulus
AV541_RS06505	COG2719	SpoVR family
AV541_RS06515	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AV541_RS06530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AV541_RS06540	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AV541_RS06545	COG1994	Peptidase M50
AV541_RS06555	COG3620	sequence-specific DNA binding
AV541_RS06555	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AV541_RS06555	COG0617	tRNA 3'-terminal CCA addition
AV541_RS06580	COG0517	IMP dehydrogenase activity
AV541_RS06595	COG1674	ftsk spoiiie
AV541_RS06605	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AV541_RS06610	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AV541_RS06615	COG4651	solute:proton antiporter activity
AV541_RS06615	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AV541_RS06620	COG0217	transcriptional regulatory protein
AV541_RS06630	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AV541_RS06665	COG0151	Belongs to the GarS family
AV541_RS06680	COG0179	Fumarylacetoacetate (FAA) hydrolase
AV541_RS06685	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AV541_RS06705	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AV541_RS06710	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AV541_RS06715	COG2353	YceI-like domain
AV541_RS06720	COG2514	catechol 2,3-dioxygenase activity
AV541_RS06725	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AV541_RS06730	COG0287	Prephenate dehydrogenase
AV541_RS06775	COG0456	acetyltransferase
AV541_RS06815	COG0730	response to heat
AV541_RS06850	COG0167	dihydroorotate dehydrogenase activity
AV541_RS06865	COG1116	anion transmembrane transporter activity
AV541_RS06865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AV541_RS06870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AV541_RS06875	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AV541_RS06920	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AV541_RS06935	COG1073	alpha beta
AV541_RS06965	COG1028	Short-chain dehydrogenase reductase Sdr
AV541_RS07000	COG1760	l-serine dehydratase
AV541_RS07010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AV541_RS07020	COG0295	cytidine deaminase activity
AV541_RS07065	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AV541_RS07110	COG1573	uracil-dna glycosylase
AV541_RS07125	COG3842	ATPase activity
AV541_RS07150	COG0561	phosphatase activity
AV541_RS07155	COG0017	Asparaginyl-tRNA synthetase
AV541_RS07160	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AV541_RS07165	COG2217	Heavy metal translocating P-type atpase
AV541_RS07170	COG0640	Transcriptional regulator
AV541_RS07175	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AV541_RS07180	COG0739	heme binding
AV541_RS07180	COG0741	lytic transglycosylase activity
AV541_RS07180	COG1196	nuclear chromosome segregation
AV541_RS07190	COG0779	Required for maturation of 30S ribosomal subunits
AV541_RS07195	COG0195	Participates in both transcription termination and antitermination
AV541_RS07205	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AV541_RS07215	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AV541_RS07215	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AV541_RS07225	COG0395	ABC-type sugar transport system, permease component
AV541_RS07250	COG0351	phosphomethylpyrimidine kinase
AV541_RS07255	COG0477	Major facilitator Superfamily
AV541_RS07265	COG2022	thiamine diphosphate biosynthetic process
AV541_RS07265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AV541_RS07275	COG2104	thiamine diphosphate biosynthetic process
AV541_RS07280	COG0352	thiamine-phosphate diphosphorylase activity
AV541_RS07290	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AV541_RS07295	COG1587	Uroporphyrinogen-III synthase
AV541_RS07300	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AV541_RS07300	COG1648	precorrin-2 dehydrogenase activity
AV541_RS07305	COG0175	sulfate reduction
AV541_RS07310	COG0730	response to heat
AV541_RS07315	COG1648	precorrin-2 dehydrogenase activity
AV541_RS07315	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AV541_RS07320	COG2046	Belongs to the sulfate adenylyltransferase family
AV541_RS07325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AV541_RS07350	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AV541_RS07355	COG2264	protein methyltransferase activity
AV541_RS07365	COG0489	protein tyrosine kinase activity
AV541_RS07470	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AV541_RS07485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AV541_RS07510	COG1970	mechanosensitive ion channel activity
AV541_RS07515	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AV541_RS07545	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AV541_RS07550	COG0646	methionine synthase
AV541_RS07550	COG1410	methionine synthase
AV541_RS07565	COG0740	serine-type endopeptidase activity
AV541_RS07570	COG0544	peptidyl-prolyl cis-trans isomerase activity
AV541_RS07595	COG3870	Protein conserved in bacteria
AV541_RS07605	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AV541_RS07610	COG1293	RNA-binding protein homologous to eukaryotic snRNP
AV541_RS07615	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AV541_RS07620	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AV541_RS07630	COG1309	transcriptional regulator
AV541_RS07640	COG1012	belongs to the aldehyde dehydrogenase family
AV541_RS07640	COG2030	dehydratase
AV541_RS07645	COG0318	PFAM AMP-dependent synthetase and ligase
AV541_RS07650	COG1028	Short-chain dehydrogenase reductase Sdr
AV541_RS07665	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AV541_RS07670	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AV541_RS07690	COG0803	Belongs to the bacterial solute-binding protein 9 family
AV541_RS07695	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AV541_RS07705	COG0589	response to stress
AV541_RS07715	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AV541_RS07715	COG3620	sequence-specific DNA binding
AV541_RS07715	COG0617	tRNA 3'-terminal CCA addition
AV541_RS07720	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AV541_RS07735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AV541_RS07840	COG1063	alcohol dehydrogenase
AV541_RS07850	COG1254	Belongs to the acylphosphatase family
AV541_RS07855	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AV541_RS07870	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AV541_RS07875	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AV541_RS07895	COG0114	fumarate hydratase activity
AV541_RS07905	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AV541_RS07920	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AV541_RS07960	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AV541_RS07970	COG0423	glycine-tRNA ligase activity
AV541_RS07975	COG0542	response to heat
AV541_RS07980	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AV541_RS08015	COG0527	aspartate kinase activity
AV541_RS08025	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AV541_RS08060	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AV541_RS08065	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AV541_RS08070	COG0509	glycine decarboxylation via glycine cleavage system
AV541_RS08095	COG2151	metal-sulfur cluster biosynthetic enzyme
AV541_RS08100	COG0861	Integral membrane protein TerC family
AV541_RS08140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AV541_RS08145	COG3335	DDE superfamily endonuclease
AV541_RS08160	COG0789	Transcriptional regulator
AV541_RS08165	COG1414	Transcriptional regulator
AV541_RS08170	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AV541_RS08185	COG0247	lactate metabolic process
AV541_RS08200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AV541_RS08265	COG3744	PilT protein domain protein
AV541_RS08270	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AV541_RS08280	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AV541_RS08290	COG2226	methyltransferase
AV541_RS08295	COG2226	methyltransferase
AV541_RS08305	COG3448	diguanylate cyclase activity
AV541_RS08305	COG4175	Glycine betaine
AV541_RS08310	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AV541_RS08330	COG2104	thiamine diphosphate biosynthetic process
AV541_RS08340	COG0517	IMP dehydrogenase activity
AV541_RS08365	COG0747	negative chemotaxis
AV541_RS08370	COG0604	alcohol dehydrogenase
AV541_RS08375	COG0492	ferredoxin-NADP+ reductase activity
AV541_RS08405	COG1028	Short-chain dehydrogenase reductase Sdr
AV541_RS08420	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AV541_RS08425	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AV541_RS08430	COG1104	cysteine desulfurase activity
AV541_RS08440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AV541_RS08445	COG1121	(ABC) transporter
AV541_RS08470	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AV541_RS08475	COG0594	ribonuclease P activity
AV541_RS08480	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AV541_RS08485	COG0706	membrane insertase activity
AV541_RS08495	COG2890	protein-(glutamine-N5) methyltransferase activity
AV541_RS08525	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AV541_RS08550	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AV541_RS08555	COG0131	Imidazoleglycerol-phosphate dehydratase
AV541_RS08560	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AV541_RS08565	COG0778	Nitroreductase
AV541_RS08570	COG1028	Short-chain dehydrogenase reductase Sdr
AV541_RS08605	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AV541_RS08610	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AV541_RS08625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AV541_RS08630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AV541_RS08635	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AV541_RS08640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AV541_RS08655	COG0564	pseudouridine synthase activity
AV541_RS08660	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AV541_RS08665	COG2255	four-way junction helicase activity
AV541_RS08740	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AV541_RS08740	COG1605	Chorismate mutase
AV541_RS08745	COG0805	protein transport
AV541_RS08755	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AV541_RS08760	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AV541_RS08810	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AV541_RS08815	COG0792	nuclease activity
AV541_RS08825	COG0492	ferredoxin-NADP+ reductase activity
AV541_RS08830	COG1028	Short-chain dehydrogenase reductase Sdr
AV541_RS08850	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AV541_RS08875	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AV541_RS08895	COG2105	PFAM AIG2 family protein
AV541_RS08900	COG0745	RESPONSE REGULATOR receiver
AV541_RS08910	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AV541_RS08915	COG1067	ATP-dependent peptidase activity
AV541_RS08935	COG0667	Aldo Keto reductase
AV541_RS08980	COG2002	toxin-antitoxin pair type II binding
AV541_RS09020	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AV541_RS09025	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AV541_RS09040	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
AV541_RS09045	COG1597	lipid kinase activity
AV541_RS09060	COG0123	including yeast histone deacetylase and acetoin utilization protein
AV541_RS09070	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AV541_RS09080	COG0004	ammonium transporteR
AV541_RS09085	COG0347	Belongs to the P(II) protein family
AV541_RS09090	COG1420	regulation of RNA biosynthetic process
AV541_RS09095	COG0314	molybdopterin synthase activity
AV541_RS09170	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AV541_RS09215	COG4712	double-strand break repair protein
AV541_RS09225	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AV541_RS09230	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AV541_RS09235	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AV541_RS09240	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AV541_RS09245	COG0649	NAD binding
AV541_RS09250	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AV541_RS09255	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AV541_RS09265	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AV541_RS09270	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AV541_RS09275	COG0839	Belongs to the complex I subunit 6 family
AV541_RS09280	COG0713	ATP synthesis coupled electron transport
AV541_RS09295	COG1007	ATP synthesis coupled electron transport
AV541_RS09300	COG0018	arginyl-trna synthetase
AV541_RS09305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AV541_RS09310	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AV541_RS09330	COG2070	2-Nitropropane dioxygenase
AV541_RS09360	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AV541_RS09365	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AV541_RS09375	COG0582	viral genome integration into host DNA
AV541_RS09445	COG0513	Belongs to the DEAD box helicase family
AV541_RS09470	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AV541_RS09500	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
AV541_RS09505	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AV541_RS09685	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AV541_RS09690	COG0758	DNA mediated transformation
AV541_RS09690	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AV541_RS09695	COG3546	catalase activity
AV541_RS09720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AV541_RS09725	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AV541_RS09735	COG0717	Belongs to the dCTP deaminase family
AV541_RS09755	COG1028	Short-chain dehydrogenase reductase Sdr
AV541_RS09760	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AV541_RS09795	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AV541_RS09805	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AV541_RS09810	COG0704	Plays a role in the regulation of phosphate uptake
AV541_RS09815	COG4191	Histidine kinase
AV541_RS09820	COG0745	RESPONSE REGULATOR receiver
AV541_RS09825	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AV541_RS09830	COG1187	pseudouridine synthase activity
AV541_RS09855	COG2414	aldehyde ferredoxin oxidoreductase
AV541_RS09870	COG1902	pentaerythritol trinitrate reductase activity
AV541_RS09895	COG0539	negative regulation of cytoplasmic translation
AV541_RS09905	COG0802	atpase or kinase
AV541_RS09920	COG4242	Belongs to the peptidase S51 family
AV541_RS09925	COG1309	transcriptional regulator
AV541_RS09940	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AV541_RS09945	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AV541_RS09950	COG1968	undecaprenyl-diphosphatase activity
AV541_RS09960	COG0484	heat shock protein binding
AV541_RS09965	COG1278	Cold shock
AV541_RS10005	COG0508	dehydrogenase complex catalyzes the overall conversion of
AV541_RS10015	COG0583	DNA-binding transcription factor activity
AV541_RS10020	COG0631	protein serine/threonine phosphatase activity
AV541_RS10025	COG0105	UTP biosynthetic process
AV541_RS10035	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AV541_RS10065	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AV541_RS10125	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AV541_RS10135	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AV541_RS10140	COG0222	ribosome binding
AV541_RS10150	COG3584	3D domain protein
AV541_RS10150	COG3583	domain protein
AV541_RS10160	COG1461	Dihydroxyacetone kinase
AV541_RS10170	COG0686	Belongs to the AlaDH PNT family
AV541_RS10190	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AV541_RS10200	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AV541_RS10600	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AV541_RS10635	COG0109	protoheme IX farnesyltransferase activity
AV541_RS10635	COG1612	heme a metabolic process
AV541_RS10640	COG1612	heme a metabolic process
AV541_RS10640	COG0109	protoheme IX farnesyltransferase activity
AV541_RS10900	COG1653	transport