locus-tag	class	description
TSC_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TSC_RS00010	COG0592	DNA-directed DNA polymerase activity
TSC_RS00015	COG0148	phosphopyruvate hydratase activity
TSC_RS00040	COG0631	protein serine/threonine phosphatase activity
TSC_RS00045	COG0105	UTP biosynthetic process
TSC_RS00055	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TSC_RS00085	COG0315	cyclic pyranopterin monophosphate synthase activity
TSC_RS00100	COG2010	Cytochrome c
TSC_RS00105	COG0535	radical SAM domain protein
TSC_RS00115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TSC_RS00120	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TSC_RS00130	COG1842	Phage shock protein A
TSC_RS00140	COG1131	(ABC) transporter
TSC_RS00145	COG0842	Transport permease protein
TSC_RS00160	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TSC_RS00170	COG1278	Cold shock
TSC_RS00175	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TSC_RS00195	COG2860	membrane
TSC_RS00200	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TSC_RS00245	COG2414	aldehyde ferredoxin oxidoreductase
TSC_RS00290	COG1131	(ABC) transporter
TSC_RS00315	COG3956	TIGRFAM MazG family protein
TSC_RS00325	COG0693	protein deglycase activity
TSC_RS00330	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TSC_RS00340	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TSC_RS00350	COG1937	Protein conserved in bacteria
TSC_RS00360	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TSC_RS00360	COG0674	pyruvate-flavodoxin oxidoreductase activity
TSC_RS00365	COG1013	pyruvate-flavodoxin oxidoreductase activity
TSC_RS00395	COG0459	protein refolding
TSC_RS00400	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TSC_RS00410	COG0714	Associated with various cellular activities
TSC_RS00420	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TSC_RS00430	COG0166	Belongs to the GPI family
TSC_RS00435	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TSC_RS00440	COG1612	heme a metabolic process
TSC_RS00440	COG0109	protoheme IX farnesyltransferase activity
TSC_RS00450	COG1845	cytochrome c oxidase, subunit III
TSC_RS00450	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TSC_RS00465	COG1845	cytochrome c oxidase, subunit III
TSC_RS00475	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TSC_RS00480	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TSC_RS00505	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TSC_RS00510	COG2814	Major facilitator Superfamily
TSC_RS00515	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TSC_RS00520	COG0581	inorganic phosphate transmembrane transporter activity
TSC_RS00525	COG0573	inorganic phosphate transmembrane transporter activity
TSC_RS00535	COG0482	sulfurtransferase activity
TSC_RS00555	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TSC_RS00560	COG0735	belongs to the Fur family
TSC_RS00575	COG0583	DNA-binding transcription factor activity
TSC_RS00580	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
TSC_RS00585	COG0508	dehydrogenase complex catalyzes the overall conversion of
TSC_RS00590	COG0181	hydroxymethylbilane synthase activity
TSC_RS00600	COG0285	dihydrofolate synthase activity
TSC_RS00605	COG0436	Aminotransferase
TSC_RS00610	COG0521	Mo-molybdopterin cofactor biosynthetic process
TSC_RS00625	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TSC_RS00630	COG0154	amidase activity
TSC_RS00635	COG0301	tRNA thio-modification
TSC_RS00645	COG0243	molybdopterin cofactor binding
TSC_RS00655	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TSC_RS00665	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TSC_RS00670	COG1653	transport
TSC_RS00685	COG0033	Phosphoglucomutase
TSC_RS00690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TSC_RS00700	COG2814	Major facilitator Superfamily
TSC_RS00710	COG0517	IMP dehydrogenase activity
TSC_RS00710	COG0516	GMP reductase activity
TSC_RS00715	COG1950	PFAM Membrane protein of
TSC_RS00735	COG0406	alpha-ribazole phosphatase activity
TSC_RS00740	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TSC_RS00745	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TSC_RS00755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TSC_RS00760	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TSC_RS00765	COG1496	oxidoreductase activity
TSC_RS00775	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TSC_RS00780	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TSC_RS00785	COG1993	acr, cog1993
TSC_RS00790	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TSC_RS00800	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TSC_RS00810	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TSC_RS00815	COG1335	isochorismatase
TSC_RS00820	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TSC_RS00825	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TSC_RS00855	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TSC_RS00860	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TSC_RS00865	COG0250	Participates in transcription elongation, termination and antitermination
TSC_RS00875	COG0081	regulation of translation
TSC_RS00880	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TSC_RS00885	COG0222	ribosome binding
TSC_RS00890	COG0163	prenyltransferase activity
TSC_RS00895	COG1960	acyl-CoA dehydrogenase activity
TSC_RS00900	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TSC_RS00905	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TSC_RS00920	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TSC_RS00925	COG0066	3-isopropylmalate dehydratase activity
TSC_RS00940	COG0189	ligase activity
TSC_RS00945	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TSC_RS00950	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TSC_RS00955	COG1543	Belongs to the glycosyl hydrolase 57 family
TSC_RS00960	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TSC_RS00960	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TSC_RS00965	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TSC_RS00990	COG0791	NLP P60 protein
TSC_RS00990	COG1388	LysM domain
TSC_RS00995	COG0778	Nitroreductase
TSC_RS01000	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TSC_RS01005	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TSC_RS01010	COG0477	Major facilitator Superfamily
TSC_RS01025	COG1694	Mazg nucleotide pyrophosphohydrolase
TSC_RS01040	COG1803	Methylglyoxal synthase
TSC_RS01050	COG2271	Major facilitator Superfamily
TSC_RS01070	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TSC_RS01095	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TSC_RS01100	COG0359	binds to the 23S rRNA
TSC_RS01105	COG0300	oxidoreductase activity
TSC_RS01115	COG0321	lipoyl(octanoyl) transferase activity
TSC_RS01120	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TSC_RS01150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TSC_RS01165	COG1598	PFAM Uncharacterised protein family UPF0150
TSC_RS01170	COG0022	dehydrogenase e1 component
TSC_RS01175	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TSC_RS01180	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TSC_RS01205	COG2226	methyltransferase
TSC_RS01210	COG0432	Pfam Uncharacterised protein family UPF0047
TSC_RS01225	COG0668	transmembrane transport
TSC_RS01230	COG3253	May function as heme-dependent peroxidase
TSC_RS01260	COG0642	Histidine kinase
TSC_RS01275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TSC_RS01280	COG1136	(ABC) transporter
TSC_RS01285	COG1136	(ABC) transporter
TSC_RS01285	COG0577	efflux transmembrane transporter activity
TSC_RS01295	COG0632	four-way junction helicase activity
TSC_RS01300	COG1024	Enoyl-CoA hydratase
TSC_RS01320	COG0508	dehydrogenase complex catalyzes the overall conversion of
TSC_RS01335	COG1404	Belongs to the peptidase S8 family
TSC_RS01345	COG0137	argininosuccinate synthase activity
TSC_RS01350	COG0165	Argininosuccinate lyase
TSC_RS01355	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TSC_RS01355	COG0165	Argininosuccinate lyase
TSC_RS01370	COG0505	Belongs to the CarA family
TSC_RS01375	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TSC_RS01430	COG2244	polysaccharide biosynthetic process
TSC_RS01440	COG1216	Glycosyl transferase, family 2
TSC_RS01450	COG0438	transferase activity, transferring glycosyl groups
TSC_RS01460	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TSC_RS01470	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TSC_RS01500	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TSC_RS01505	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TSC_RS01510	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TSC_RS01515	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TSC_RS01530	COG0799	negative regulation of ribosome biogenesis
TSC_RS01535	COG4636	protein conserved in cyanobacteria
TSC_RS01545	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TSC_RS01570	COG0739	heme binding
TSC_RS01580	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TSC_RS01585	COG0825	malonyl-CoA metabolic process
TSC_RS01605	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TSC_RS01615	COG1278	Cold shock
TSC_RS01620	COG0484	heat shock protein binding
TSC_RS01625	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TSC_RS01630	COG1968	undecaprenyl-diphosphatase activity
TSC_RS01635	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TSC_RS01640	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TSC_RS01655	COG1309	transcriptional regulator
TSC_RS01675	COG0802	atpase or kinase
TSC_RS01690	COG0437	4 iron, 4 sulfur cluster binding
TSC_RS01715	COG1252	NADH dehydrogenase
TSC_RS01725	COG3706	GGDEF domain
TSC_RS01730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TSC_RS01745	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TSC_RS01750	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TSC_RS01755	COG1185	polyribonucleotide nucleotidyltransferase activity
TSC_RS01760	COG3118	belongs to the thioredoxin family
TSC_RS01765	COG0416	fatty acid biosynthetic process
TSC_RS01775	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TSC_RS01790	COG0284	orotidine-5'-phosphate decarboxylase activity
TSC_RS01795	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TSC_RS01805	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TSC_RS01825	COG0822	iron-sulfur transferase activity
TSC_RS01830	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TSC_RS01840	COG2132	Multicopper oxidase
TSC_RS01865	COG2226	methyltransferase
TSC_RS01880	COG5002	protein histidine kinase activity
TSC_RS01885	COG0745	RESPONSE REGULATOR receiver
TSC_RS01915	COG0719	Fe-S assembly protein
TSC_RS01920	COG0719	Fe-S assembly protein
TSC_RS01925	COG0396	ATPase activity
TSC_RS01940	COG0446	pyridine nucleotide-disulphide oxidoreductase
TSC_RS01945	COG1136	(ABC) transporter
TSC_RS01950	COG1136	(ABC) transporter
TSC_RS01950	COG0577	efflux transmembrane transporter activity
TSC_RS01970	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TSC_RS01980	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TSC_RS02010	COG4948	Mandelate Racemase Muconate Lactonizing
TSC_RS02025	COG0354	folic acid binding
TSC_RS02030	COG1546	Belongs to the CinA family
TSC_RS02030	COG1058	Belongs to the CinA family
TSC_RS02035	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TSC_RS02045	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TSC_RS02045	COG1418	mRNA catabolic process
TSC_RS02060	COG1077	Cell shape determining protein MreB Mrl
TSC_RS02065	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TSC_RS02090	COG0235	Class ii aldolase
TSC_RS02110	COG1177	transmembrane transport
TSC_RS02115	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TSC_RS02120	COG1607	acyl-coa hydrolase
TSC_RS02125	COG2154	pterin-4-alpha-carbinolamine dehydratase
TSC_RS02135	COG0277	FAD linked oxidase domain protein
TSC_RS02155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TSC_RS02170	COG4555	ABC transporter
TSC_RS02175	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TSC_RS02185	COG0667	Aldo Keto reductase
TSC_RS02200	COG0517	IMP dehydrogenase activity
TSC_RS02210	COG1067	ATP-dependent peptidase activity
TSC_RS02215	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TSC_RS02225	COG0745	RESPONSE REGULATOR receiver
TSC_RS02230	COG2105	PFAM AIG2 family protein
TSC_RS02240	COG0297	glycogen (starch) synthase activity
TSC_RS02245	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TSC_RS02250	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TSC_RS02265	COG0142	geranyltranstransferase activity
TSC_RS02275	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TSC_RS02305	COG0582	viral genome integration into host DNA
TSC_RS02345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TSC_RS02360	COG0516	GMP reductase activity
TSC_RS02360	COG0517	IMP dehydrogenase activity
TSC_RS02375	COG2205	protein histidine kinase activity
TSC_RS02395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TSC_RS02410	COG1324	tolerance protein
TSC_RS02415	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TSC_RS02420	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TSC_RS02425	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TSC_RS02430	COG2197	response regulator
TSC_RS02445	COG1132	(ABC) transporter
TSC_RS02450	COG1132	(ABC) transporter
TSC_RS02455	COG0285	dihydrofolate synthase activity
TSC_RS02465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSC_RS02470	COG0601	transmembrane transport
TSC_RS02475	COG0747	negative chemotaxis
TSC_RS02505	COG0174	glutamine synthetase
TSC_RS02510	COG0737	Belongs to the 5'-nucleotidase family
TSC_RS02530	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TSC_RS02535	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TSC_RS02540	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TSC_RS02545	COG0788	formyltetrahydrofolate deformylase activity
TSC_RS02570	COG2358	TRAP transporter, solute receptor (TAXI family
TSC_RS02590	COG2814	Major facilitator Superfamily
TSC_RS02595	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TSC_RS02600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TSC_RS02605	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TSC_RS02625	COG2050	protein possibly involved in aromatic compounds catabolism
TSC_RS02630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TSC_RS02660	COG0247	lactate metabolic process
TSC_RS02665	COG0277	FAD linked oxidase domain protein
TSC_RS02670	COG0277	FAD linked oxidase domain protein
TSC_RS02675	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TSC_RS02685	COG0789	Transcriptional regulator
TSC_RS02695	COG2045	Belongs to the ComB family
TSC_RS02700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TSC_RS02705	COG1136	(ABC) transporter
TSC_RS02715	COG1024	Enoyl-CoA hydratase
TSC_RS02730	COG0318	PFAM AMP-dependent synthetase and ligase
TSC_RS02735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TSC_RS02740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TSC_RS02755	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TSC_RS02780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TSC_RS02795	COG1837	Belongs to the UPF0109 family
TSC_RS02800	COG0706	membrane insertase activity
TSC_RS02805	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TSC_RS02860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TSC_RS02865	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TSC_RS02870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TSC_RS02875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TSC_RS02880	COG1028	Short-chain dehydrogenase reductase Sdr
TSC_RS02885	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TSC_RS02890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TSC_RS02895	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TSC_RS02915	COG1007	ATP synthesis coupled electron transport
TSC_RS02920	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TSC_RS02925	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TSC_RS02930	COG0713	ATP synthesis coupled electron transport
TSC_RS02935	COG0839	Belongs to the complex I subunit 6 family
TSC_RS02940	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TSC_RS02945	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TSC_RS02950	COG1034	ATP synthesis coupled electron transport
TSC_RS02955	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TSC_RS02960	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TSC_RS02965	COG0649	NAD binding
TSC_RS02970	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TSC_RS02975	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TSC_RS02980	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TSC_RS02985	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TSC_RS02995	COG4712	double-strand break repair protein
TSC_RS03040	COG0131	Imidazoleglycerol-phosphate dehydratase
TSC_RS03045	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TSC_RS03050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TSC_RS03055	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TSC_RS03065	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TSC_RS03085	COG0861	Integral membrane protein TerC family
TSC_RS03090	COG2151	metal-sulfur cluster biosynthetic enzyme
TSC_RS03095	COG1714	RDD family
TSC_RS03100	COG0616	signal peptide processing
TSC_RS03105	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TSC_RS03110	COG0372	Belongs to the citrate synthase family
TSC_RS03115	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TSC_RS03125	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TSC_RS03130	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TSC_RS03130	COG0758	DNA mediated transformation
TSC_RS03135	COG3546	catalase activity
TSC_RS03140	COG0583	DNA-binding transcription factor activity
TSC_RS03150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TSC_RS03155	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TSC_RS03160	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TSC_RS03170	COG0717	Belongs to the dCTP deaminase family
TSC_RS03180	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TSC_RS03180	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TSC_RS03185	COG1028	Short-chain dehydrogenase reductase Sdr
TSC_RS03190	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TSC_RS03215	COG0515	serine threonine protein kinase
TSC_RS03215	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TSC_RS03225	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TSC_RS03235	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TSC_RS03245	COG0704	Plays a role in the regulation of phosphate uptake
TSC_RS03250	COG2205	protein histidine kinase activity
TSC_RS03255	COG0745	RESPONSE REGULATOR receiver
TSC_RS03265	COG0582	viral genome integration into host DNA
TSC_RS03295	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TSC_RS03320	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
TSC_RS03325	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TSC_RS03330	COG0248	Ppx GppA phosphatase
TSC_RS03340	COG1063	alcohol dehydrogenase
TSC_RS03355	COG3181	Tripartite tricarboxylate transporter family receptor
TSC_RS03360	COG0281	malic enzyme
TSC_RS03375	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TSC_RS03380	COG0509	glycine decarboxylation via glycine cleavage system
TSC_RS03385	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TSC_RS03390	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TSC_RS03410	COG0243	molybdopterin cofactor binding
TSC_RS03420	COG2197	response regulator
TSC_RS03430	COG0196	riboflavin kinase activity
TSC_RS03435	COG0494	nUDIX hydrolase
TSC_RS03455	COG2813	Specifically methylates the guanine in position
TSC_RS03465	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
TSC_RS03475	COG0358	DNA primase activity
TSC_RS03490	COG1205	dead DEAH box helicase
TSC_RS03490	COG1111	helicase
TSC_RS03495	COG0456	acetyltransferase
TSC_RS03505	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TSC_RS03510	COG0009	L-threonylcarbamoyladenylate synthase
TSC_RS03515	COG1459	type II secretion system
TSC_RS03535	COG3706	GGDEF domain
TSC_RS03540	COG0287	Prephenate dehydrogenase
TSC_RS03545	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TSC_RS03550	COG2514	catechol 2,3-dioxygenase activity
TSC_RS03555	COG2353	YceI-like domain
TSC_RS03560	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TSC_RS03565	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TSC_RS03585	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TSC_RS03590	COG0179	Fumarylacetoacetate (FAA) hydrolase
TSC_RS03600	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TSC_RS03605	COG0151	Belongs to the GarS family
TSC_RS03610	COG5002	protein histidine kinase activity
TSC_RS03610	COG2176	DNA-directed DNA polymerase activity
TSC_RS03620	COG2205	protein histidine kinase activity
TSC_RS03625	COG0517	IMP dehydrogenase activity
TSC_RS03625	COG0617	tRNA 3'-terminal CCA addition
TSC_RS03625	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TSC_RS03635	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TSC_RS03645	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TSC_RS03650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TSC_RS03655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TSC_RS03665	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TSC_RS03665	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TSC_RS03670	COG1733	regulation of RNA biosynthetic process
TSC_RS03675	COG2894	cell division
TSC_RS03680	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TSC_RS03685	COG0772	Belongs to the SEDS family
TSC_RS03690	COG3842	ATPase activity
TSC_RS03695	COG1176	ABC-type spermidine putrescine transport system, permease component I
TSC_RS03700	COG1177	transmembrane transport
TSC_RS03705	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TSC_RS03710	COG2010	Cytochrome c
TSC_RS03715	COG0129	dihydroxy-acid dehydratase activity
TSC_RS03720	COG1028	Short-chain dehydrogenase reductase Sdr
TSC_RS03735	COG0473	3-isopropylmalate dehydrogenase activity
TSC_RS03740	COG0066	3-isopropylmalate dehydratase activity
TSC_RS03745	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TSC_RS03760	COG0180	Tryptophanyl-tRNA synthetase
TSC_RS03775	COG2165	general secretion pathway protein
TSC_RS03785	COG4970	Tfp pilus assembly protein FimT
TSC_RS03790	COG4970	Tfp pilus assembly protein FimT
TSC_RS03795	COG0183	Belongs to the thiolase family
TSC_RS03805	COG2361	Protein of unknown function DUF86
TSC_RS03820	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TSC_RS03825	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TSC_RS03840	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TSC_RS03845	COG1254	Belongs to the acylphosphatase family
TSC_RS03855	COG1063	alcohol dehydrogenase
TSC_RS03860	COG2133	pyrroloquinoline quinone binding
TSC_RS03865	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TSC_RS03890	COG0420	3'-5' exonuclease activity
TSC_RS03895	COG0419	ATPase involved in DNA repair
TSC_RS03920	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TSC_RS03925	COG0612	Peptidase, M16
TSC_RS03930	COG0612	Peptidase, M16
TSC_RS03935	COG0697	spore germination
TSC_RS03940	COG1250	3-hydroxyacyl-CoA dehydrogenase
TSC_RS03960	COG4956	integral membrane protein (PIN domain superfamily)
TSC_RS03965	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TSC_RS03970	COG0542	response to heat
TSC_RS03975	COG0423	glycine-tRNA ligase activity
TSC_RS03990	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TSC_RS04000	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TSC_RS04035	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TSC_RS04060	COG1024	Enoyl-CoA hydratase
TSC_RS04065	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TSC_RS04075	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TSC_RS04085	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TSC_RS04090	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TSC_RS04095	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TSC_RS04105	COG0861	Integral membrane protein TerC family
TSC_RS04110	COG0492	ferredoxin-NADP+ reductase activity
TSC_RS04115	COG0028	Belongs to the TPP enzyme family
TSC_RS04120	COG0440	acetolactate synthase activity
TSC_RS04125	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TSC_RS04135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TSC_RS04150	COG4555	ABC transporter
TSC_RS04175	COG4970	Tfp pilus assembly protein FimT
TSC_RS04180	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TSC_RS04190	COG1573	uracil-dna glycosylase
TSC_RS04210	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TSC_RS04225	COG1316	TRANSCRIPTIONal
TSC_RS04260	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TSC_RS04275	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TSC_RS04285	COG1269	ATP hydrolysis coupled proton transport
TSC_RS04295	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TSC_RS04300	COG1527	subunit (C
TSC_RS04305	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TSC_RS04310	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TSC_RS04315	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TSC_RS04320	COG1394	ATPase activity, coupled to movement of substances
TSC_RS04325	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TSC_RS04375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TSC_RS04385	COG1760	l-serine dehydratase
TSC_RS04395	COG0481	GTPase activity
TSC_RS04405	COG1960	acyl-CoA dehydrogenase activity
TSC_RS04410	COG0183	Belongs to the thiolase family
TSC_RS04420	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TSC_RS04425	COG1028	Short-chain dehydrogenase reductase Sdr
TSC_RS04440	COG0559	Belongs to the binding-protein-dependent transport system permease family
TSC_RS04455	COG2030	dehydratase
TSC_RS04465	COG0596	Alpha beta hydrolase
TSC_RS04475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TSC_RS04480	COG2909	trisaccharide binding
TSC_RS04485	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TSC_RS04485	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TSC_RS04495	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TSC_RS04500	COG0195	Participates in both transcription termination and antitermination
TSC_RS04505	COG0779	Required for maturation of 30S ribosomal subunits
TSC_RS04510	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TSC_RS04510	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TSC_RS04520	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TSC_RS04520	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TSC_RS04540	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TSC_RS04540	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TSC_RS04545	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TSC_RS04545	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TSC_RS04550	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TSC_RS04570	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TSC_RS04575	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TSC_RS04580	COG1702	phosphate starvation-inducible protein PhoH
TSC_RS04590	COG4864	UPF0365 protein
TSC_RS04600	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TSC_RS04615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TSC_RS04620	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TSC_RS04625	COG0824	Thioesterase
TSC_RS04635	COG0557	exoribonuclease II activity
TSC_RS04645	COG1355	regulation of microtubule-based process
TSC_RS04650	COG1353	crispr-associated protein
TSC_RS04650	COG0617	tRNA 3'-terminal CCA addition
TSC_RS04655	COG0237	dephospho-CoA kinase activity
TSC_RS04660	COG4221	oxidoreductase activity
TSC_RS04670	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TSC_RS04705	COG0165	Argininosuccinate lyase
TSC_RS04710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TSC_RS04735	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TSC_RS04740	COG1185	polyribonucleotide nucleotidyltransferase activity
TSC_RS04745	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TSC_RS04760	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TSC_RS04765	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TSC_RS04775	COG1100	Small GTP-binding protein
TSC_RS04790	COG0010	Belongs to the arginase family
TSC_RS04805	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TSC_RS04810	COG0511	ligase activity, forming carbon-carbon bonds
TSC_RS04815	COG0439	Biotin carboxylase
TSC_RS04825	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TSC_RS04830	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TSC_RS04835	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TSC_RS04845	COG2181	nitrate reductase activity
TSC_RS04845	COG0247	lactate metabolic process
TSC_RS04855	COG0861	Integral membrane protein TerC family
TSC_RS04860	COG2819	hydrolase of the alpha beta superfamily
TSC_RS04870	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TSC_RS04875	COG0438	transferase activity, transferring glycosyl groups
TSC_RS04920	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TSC_RS04925	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TSC_RS04935	COG3383	formate dehydrogenase (NAD+) activity
TSC_RS04935	COG0243	molybdopterin cofactor binding
TSC_RS04940	COG0437	4 iron, 4 sulfur cluster binding
TSC_RS04955	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TSC_RS04960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TSC_RS04995	COG4983	Phage plasmid primase, P4 family domain protein
TSC_RS05015	COG3845	ABC transporter
TSC_RS05025	COG1079	Belongs to the binding-protein-dependent transport system permease family
TSC_RS05035	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TSC_RS05040	COG0494	nUDIX hydrolase
TSC_RS05050	COG0138	bifunctional purine biosynthesis protein purh
TSC_RS05060	COG2337	Toxic component of a toxin-antitoxin (TA) module
TSC_RS05065	COG3239	Fatty acid desaturase
TSC_RS05070	COG1490	D-aminoacyl-tRNA deacylase activity
TSC_RS05075	COG1307	EDD domain protein, DegV family
TSC_RS05080	COG1307	EDD domain protein, DegV family
TSC_RS05085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TSC_RS05105	COG0577	efflux transmembrane transporter activity
TSC_RS05105	COG1136	(ABC) transporter
TSC_RS05110	COG1136	(ABC) transporter
TSC_RS05130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TSC_RS05140	COG1012	belongs to the aldehyde dehydrogenase family
TSC_RS05145	COG2368	4-hydroxyphenylacetate
TSC_RS05150	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TSC_RS05185	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TSC_RS05200	COG1492	cobalamin metabolic process
TSC_RS05205	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TSC_RS05215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TSC_RS05215	COG0574	Belongs to the PEP-utilizing enzyme family
TSC_RS05220	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TSC_RS05245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TSC_RS05260	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TSC_RS05265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSC_RS05270	COG0601	transmembrane transport
TSC_RS05280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TSC_RS05290	COG2226	methyltransferase
TSC_RS05300	COG0601	transmembrane transport
TSC_RS05305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSC_RS05310	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TSC_RS05315	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
TSC_RS05320	COG2188	Transcriptional regulator
TSC_RS05325	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TSC_RS05330	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
TSC_RS05335	COG1472	Belongs to the glycosyl hydrolase 3 family
TSC_RS05345	COG1175	transmembrane transport
TSC_RS05350	COG0395	ABC-type sugar transport system, permease component
TSC_RS05355	COG0019	diaminopimelate decarboxylase activity
TSC_RS05365	COG2205	protein histidine kinase activity
TSC_RS05395	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TSC_RS05410	COG0589	response to stress
TSC_RS05425	COG1993	acr, cog1993
TSC_RS05440	COG1193	negative regulation of DNA recombination
TSC_RS05455	COG0642	Histidine kinase
TSC_RS05465	COG2010	Cytochrome c
TSC_RS05470	COG1914	H( )-stimulated, divalent metal cation uptake system
TSC_RS05490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TSC_RS05495	COG2323	membrane
TSC_RS05510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TSC_RS05520	COG3258	Cytochrome c
TSC_RS05525	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TSC_RS05530	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TSC_RS05535	COG0363	glucosamine-6-phosphate deaminase activity
TSC_RS05545	COG0723	plastoquinol--plastocyanin reductase activity
TSC_RS05550	COG0730	response to heat
TSC_RS05590	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
TSC_RS05590	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
TSC_RS05615	COG1802	Transcriptional regulator
TSC_RS05625	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TSC_RS05655	COG4638	Rieske (2fe-2S)
TSC_RS05660	COG1129	ABC transporter
TSC_RS05705	COG1942	4-Oxalocrotonate Tautomerase
TSC_RS05725	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TSC_RS05745	COG0588	phosphoglycerate mutase activity
TSC_RS05755	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TSC_RS05760	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TSC_RS05770	COG1797	cobyrinic acid a,c-diamide synthase activity
TSC_RS05775	COG2046	Belongs to the sulfate adenylyltransferase family
TSC_RS05780	COG1648	precorrin-2 dehydrogenase activity
TSC_RS05780	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TSC_RS05785	COG0730	response to heat
TSC_RS05790	COG0175	sulfate reduction
TSC_RS05795	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TSC_RS05795	COG1648	precorrin-2 dehydrogenase activity
TSC_RS05800	COG1587	Uroporphyrinogen-III synthase
TSC_RS05805	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TSC_RS05810	COG0352	thiamine-phosphate diphosphorylase activity
TSC_RS05815	COG2104	thiamine diphosphate biosynthetic process
TSC_RS05820	COG2022	thiamine diphosphate biosynthetic process
TSC_RS05825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TSC_RS05825	COG2022	thiamine diphosphate biosynthetic process
TSC_RS05830	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TSC_RS05840	COG1028	Short-chain dehydrogenase reductase Sdr
TSC_RS05845	COG0318	PFAM AMP-dependent synthetase and ligase
TSC_RS05850	COG1012	belongs to the aldehyde dehydrogenase family
TSC_RS05850	COG2030	dehydratase
TSC_RS05855	COG1960	acyl-CoA dehydrogenase activity
TSC_RS05860	COG1309	transcriptional regulator
TSC_RS05865	COG1980	fructose-bisphosphate aldolase activity
TSC_RS05895	COG2186	Transcriptional regulator
TSC_RS05900	COG0747	negative chemotaxis
TSC_RS05910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSC_RS05935	COG0395	ABC-type sugar transport system, permease component
TSC_RS05940	COG1175	transmembrane transport
TSC_RS05950	COG1609	Transcriptional regulator
TSC_RS05960	COG1607	acyl-coa hydrolase
TSC_RS05975	COG4974	Belongs to the 'phage' integrase family
TSC_RS05990	COG3396	Phenylacetate-CoA oxygenase
TSC_RS06000	COG3396	Phenylacetate-CoA oxygenase
TSC_RS06010	COG2030	dehydratase
TSC_RS06010	COG1012	belongs to the aldehyde dehydrogenase family
TSC_RS06015	COG1733	regulation of RNA biosynthetic process
TSC_RS06020	COG2193	ferroxidase activity
TSC_RS06025	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TSC_RS06030	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TSC_RS06060	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TSC_RS06100	COG2361	Protein of unknown function DUF86
TSC_RS06115	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TSC_RS06135	COG1857	crispr-associated protein
TSC_RS06200	COG1012	belongs to the aldehyde dehydrogenase family
TSC_RS06210	COG1331	Highly conserved protein containing a thioredoxin domain
TSC_RS06215	COG0183	Belongs to the thiolase family
TSC_RS06220	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TSC_RS06225	COG0477	Major facilitator Superfamily
TSC_RS06235	COG1960	acyl-CoA dehydrogenase activity
TSC_RS06240	COG2414	aldehyde ferredoxin oxidoreductase
TSC_RS06250	COG3153	acetyltransferase
TSC_RS06250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TSC_RS06255	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TSC_RS06260	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TSC_RS06265	COG1177	transmembrane transport
TSC_RS06270	COG1176	ABC-type spermidine putrescine transport system, permease component I
TSC_RS06275	COG3842	ATPase activity
TSC_RS06280	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TSC_RS06285	COG1012	belongs to the aldehyde dehydrogenase family
TSC_RS06290	COG1177	transmembrane transport
TSC_RS06295	COG1176	ABC-type spermidine putrescine transport system, permease component I
TSC_RS06300	COG3842	ATPase activity
TSC_RS06305	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TSC_RS06310	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TSC_RS06325	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TSC_RS06330	COG0803	Belongs to the bacterial solute-binding protein 9 family
TSC_RS06335	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TSC_RS06340	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TSC_RS06350	COG3383	formate dehydrogenase (NAD+) activity
TSC_RS06355	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TSC_RS06370	COG1960	acyl-CoA dehydrogenase activity
TSC_RS06375	COG2086	electron transfer activity
TSC_RS06380	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TSC_RS06390	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TSC_RS06395	COG1573	uracil-dna glycosylase
TSC_RS06400	COG1796	DNA polymerase
TSC_RS06400	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TSC_RS06415	COG0674	pyruvate-flavodoxin oxidoreductase activity
TSC_RS06415	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TSC_RS06415	COG1013	pyruvate-flavodoxin oxidoreductase activity
TSC_RS06415	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TSC_RS06425	COG2873	o-acetylhomoserine
TSC_RS06435	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TSC_RS06440	COG0215	cysteine-tRNA ligase activity
TSC_RS06445	COG1960	acyl-CoA dehydrogenase activity
TSC_RS06450	COG0183	Belongs to the thiolase family
TSC_RS06455	COG1024	Enoyl-CoA hydratase
TSC_RS06455	COG1250	3-hydroxyacyl-CoA dehydrogenase
TSC_RS06470	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TSC_RS06480	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TSC_RS06485	COG0438	transferase activity, transferring glycosyl groups
TSC_RS06490	COG0438	transferase activity, transferring glycosyl groups
TSC_RS06500	COG1215	transferase activity, transferring glycosyl groups
TSC_RS06515	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TSC_RS06515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TSC_RS06520	COG1811	Na channel or pump
TSC_RS06525	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TSC_RS06530	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TSC_RS06535	COG4948	Mandelate Racemase Muconate Lactonizing
TSC_RS06545	COG0402	S-adenosylhomocysteine deaminase activity
TSC_RS06570	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TSC_RS06575	COG0742	ribosomal rna small subunit methyltransferase
TSC_RS06590	COG2873	o-acetylhomoserine
TSC_RS06595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TSC_RS06600	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TSC_RS06605	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TSC_RS06670	COG0149	triose-phosphate isomerase activity
TSC_RS06675	COG0126	phosphoglycerate kinase activity
TSC_RS06685	COG1268	BioY protein
TSC_RS06695	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TSC_RS06710	COG1196	nuclear chromosome segregation
TSC_RS06725	COG2738	Putative neutral zinc metallopeptidase
TSC_RS06755	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TSC_RS06775	COG2897	thiosulfate sulfurtransferase activity
TSC_RS06780	COG1760	l-serine dehydratase
TSC_RS06785	COG2197	response regulator
TSC_RS06790	COG0335	large ribosomal subunit rRNA binding
TSC_RS06795	COG0336	Belongs to the RNA methyltransferase TrmD family
TSC_RS06800	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TSC_RS06810	COG0228	four-way junction DNA binding
TSC_RS06820	COG2239	Acts as a magnesium transporter
TSC_RS06830	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TSC_RS06840	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TSC_RS06845	COG1692	metallophosphoesterase
TSC_RS06870	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TSC_RS06875	COG0646	methionine synthase
TSC_RS06875	COG1410	methionine synthase
TSC_RS06880	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TSC_RS06885	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TSC_RS06890	COG0740	serine-type endopeptidase activity
TSC_RS06895	COG0544	peptidyl-prolyl cis-trans isomerase activity
TSC_RS06915	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TSC_RS06920	COG3870	Protein conserved in bacteria
TSC_RS06925	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TSC_RS06935	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TSC_RS06955	COG4475	Protein of unknown function (DUF436)
TSC_RS06975	COG0651	ATP synthesis coupled electron transport
TSC_RS06990	COG0651	ATP synthesis coupled electron transport
TSC_RS07005	COG1970	mechanosensitive ion channel activity
TSC_RS07010	COG3842	ATPase activity
TSC_RS07015	COG0572	uridine kinase
TSC_RS07035	COG2176	DNA-directed DNA polymerase activity
TSC_RS07040	COG0154	amidase activity
TSC_RS07045	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TSC_RS07055	COG1435	thymidine kinase activity
TSC_RS07060	COG0254	rRNA binding
TSC_RS07070	COG2001	Belongs to the MraZ family
TSC_RS07075	COG0275	rRNA processing
TSC_RS07085	COG0768	penicillin binding
TSC_RS07090	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TSC_RS07100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TSC_RS07105	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TSC_RS07110	COG0772	Belongs to the SEDS family
TSC_RS07115	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TSC_RS07120	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TSC_RS07125	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TSC_RS07145	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TSC_RS07150	COG2197	response regulator
TSC_RS07190	COG2391	methyltransferase activity
TSC_RS07200	COG0243	molybdopterin cofactor binding
TSC_RS07230	COG1028	Short-chain dehydrogenase reductase Sdr
TSC_RS07245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TSC_RS07265	COG1175	transmembrane transport
TSC_RS07295	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TSC_RS07300	COG2264	protein methyltransferase activity
TSC_RS07310	COG0489	protein tyrosine kinase activity
TSC_RS07320	COG0525	valine-tRNA ligase activity
TSC_RS07330	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TSC_RS07340	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TSC_RS07345	COG0134	indole-3-glycerol-phosphate synthase activity
TSC_RS07350	COG1752	Esterase of the alpha-beta hydrolase superfamily
TSC_RS07360	COG1126	abc transporter atp-binding protein
TSC_RS07370	COG2358	TRAP transporter, solute receptor (TAXI family
TSC_RS07375	COG0765	amino acid transport
TSC_RS07380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TSC_RS07390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TSC_RS07395	COG0569	domain protein
TSC_RS07400	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TSC_RS07420	COG3001	Fructosamine kinase
TSC_RS07425	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TSC_RS07430	COG4585	Histidine kinase
TSC_RS07455	COG0012	GTP binding
TSC_RS07460	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TSC_RS07470	COG0424	maF-like protein
TSC_RS07485	COG0768	penicillin binding
TSC_RS07495	COG2322	membrane
TSC_RS07515	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TSC_RS07520	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TSC_RS07530	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TSC_RS07545	COG3842	ATPase activity
TSC_RS07560	COG0124	histidyl-tRNA synthetase
TSC_RS07570	COG0384	phenazine biosynthesis protein PhzF
TSC_RS07575	COG0561	phosphatase activity
TSC_RS07590	COG0745	RESPONSE REGULATOR receiver
TSC_RS07600	COG0017	Asparaginyl-tRNA synthetase
TSC_RS07605	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TSC_RS07615	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TSC_RS07620	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TSC_RS07630	COG0640	Transcriptional regulator
TSC_RS07635	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TSC_RS07640	COG0739	heme binding
TSC_RS07645	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TSC_RS07650	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TSC_RS07655	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TSC_RS07660	COG0006	proline dipeptidase activity
TSC_RS07665	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TSC_RS07670	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TSC_RS07675	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TSC_RS07690	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TSC_RS07700	COG1994	Peptidase M50
TSC_RS07710	COG0617	tRNA 3'-terminal CCA addition
TSC_RS07710	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TSC_RS07710	COG0517	IMP dehydrogenase activity
TSC_RS07790	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TSC_RS07790	COG2199	diguanylate cyclase activity
TSC_RS07900	COG4712	double-strand break repair protein
TSC_RS07920	COG0210	DNA helicase
TSC_RS07930	COG3864	Putative metallopeptidase domain
TSC_RS07935	COG0714	Associated with various cellular activities
TSC_RS08105	COG1994	Peptidase M50
TSC_RS08150	COG1072	(Pantothenic acid kinase))
TSC_RS08185	COG1063	alcohol dehydrogenase
TSC_RS08190	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TSC_RS08195	COG1012	belongs to the aldehyde dehydrogenase family
TSC_RS08230	COG1175	transmembrane transport
TSC_RS08235	COG0395	ABC-type sugar transport system, permease component
TSC_RS08250	COG0463	Glycosyl transferase, family 2
TSC_RS08265	COG1598	PFAM Uncharacterised protein family UPF0150
TSC_RS08290	COG0582	viral genome integration into host DNA
TSC_RS08300	COG0052	Belongs to the universal ribosomal protein uS2 family
TSC_RS08305	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TSC_RS08310	COG0528	UMP kinase activity
TSC_RS08315	COG0233	cytoplasmic translational termination
TSC_RS08320	COG4589	Belongs to the CDS family
TSC_RS08325	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TSC_RS08330	COG0750	zinc metalloprotease
TSC_RS08345	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TSC_RS08350	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TSC_RS08355	COG2359	stage V sporulation protein S
TSC_RS08365	COG2137	regulation of response to DNA damage stimulus
TSC_RS08385	COG2766	serine protein kinase
TSC_RS08390	COG2718	Belongs to the UPF0229 family
TSC_RS08395	COG2719	SpoVR family
TSC_RS08400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TSC_RS08405	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TSC_RS08420	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TSC_RS08435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TSC_RS08440	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TSC_RS08445	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TSC_RS08450	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TSC_RS08460	COG3335	DDE superfamily endonuclease
TSC_RS08470	COG0730	response to heat
TSC_RS08480	COG2323	membrane
TSC_RS08495	COG2205	protein histidine kinase activity
TSC_RS08500	COG0745	RESPONSE REGULATOR receiver
TSC_RS08505	COG0671	phosphoesterase, PA-phosphatase related
TSC_RS08520	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TSC_RS08525	COG2151	metal-sulfur cluster biosynthetic enzyme
TSC_RS08565	COG2181	nitrate reductase activity
TSC_RS08580	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
TSC_RS08595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TSC_RS08600	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TSC_RS08610	COG0535	radical SAM domain protein
TSC_RS08615	COG2010	Cytochrome c
TSC_RS08625	COG3256	nitric oxide reductase
TSC_RS08630	COG2010	Cytochrome c
TSC_RS08640	COG2832	Protein of unknown function (DUF454)
TSC_RS08685	COG1252	NADH dehydrogenase
TSC_RS08690	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TSC_RS08700	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TSC_RS08705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TSC_RS08710	COG3191	aminopeptidase activity
TSC_RS08720	COG1063	alcohol dehydrogenase
TSC_RS08725	COG0714	Associated with various cellular activities
TSC_RS08740	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TSC_RS08745	COG2884	Cell division ATP-binding protein ftsE
TSC_RS08750	COG0793	Belongs to the peptidase S41A family
TSC_RS08755	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TSC_RS08755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TSC_RS08760	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TSC_RS08765	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TSC_RS08775	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TSC_RS08780	COG0159	tryptophan synthase activity
TSC_RS08785	COG0133	tryptophan synthase activity
TSC_RS08790	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TSC_RS08800	COG1744	ABC transporter substrate-binding protein PnrA-like
TSC_RS08805	COG3845	ABC transporter
TSC_RS08830	COG0745	RESPONSE REGULATOR receiver
TSC_RS08835	COG0077	Prephenate dehydratase
TSC_RS08835	COG1605	Chorismate mutase
TSC_RS08840	COG0517	IMP dehydrogenase activity
TSC_RS08855	COG1674	ftsk spoiiie
TSC_RS08860	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TSC_RS08865	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TSC_RS08870	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TSC_RS08875	COG4651	solute:proton antiporter activity
TSC_RS08875	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TSC_RS08880	COG0217	transcriptional regulatory protein
TSC_RS08885	COG0653	protein targeting
TSC_RS08890	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TSC_RS08920	COG1960	acyl-CoA dehydrogenase activity
TSC_RS08930	COG0312	modulator of DNA gyrase
TSC_RS08935	COG0312	modulator of DNA gyrase
TSC_RS08955	COG0730	response to heat
TSC_RS08980	COG0167	dihydroorotate dehydrogenase activity
TSC_RS08990	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TSC_RS09030	COG0746	molybdenum cofactor guanylyltransferase activity
TSC_RS09045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TSC_RS09070	COG0538	isocitrate dehydrogenase activity
TSC_RS09075	COG0557	exoribonuclease II activity
TSC_RS09105	COG0585	pseudouridine synthase activity
TSC_RS09125	COG2050	protein possibly involved in aromatic compounds catabolism
TSC_RS09135	COG0322	excinuclease ABC activity
TSC_RS09140	COG0018	arginyl-trna synthetase
TSC_RS09145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TSC_RS09150	COG1428	Deoxynucleoside kinase
TSC_RS09155	COG1428	Deoxynucleoside kinase
TSC_RS09160	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TSC_RS09165	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TSC_RS09170	COG0107	imidazoleglycerol-phosphate synthase activity
TSC_RS09175	COG0140	phosphoribosyl-ATP diphosphatase activity
TSC_RS09175	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TSC_RS09185	COG1494	fructose-1,6-bisphosphatase
TSC_RS09210	COG0395	ABC-type sugar transport system, permease component
TSC_RS09215	COG1175	transmembrane transport
TSC_RS09260	COG0084	hydrolase, TatD family'
TSC_RS09265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TSC_RS09275	COG0017	Asparaginyl-tRNA synthetase
TSC_RS09285	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TSC_RS09300	COG2009	succinate dehydrogenase
TSC_RS09305	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TSC_RS09335	COG0318	PFAM AMP-dependent synthetase and ligase
TSC_RS09340	COG1104	cysteine desulfurase activity
TSC_RS09345	COG1959	2 iron, 2 sulfur cluster binding
TSC_RS09350	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TSC_RS09365	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TSC_RS09370	COG2255	four-way junction helicase activity
TSC_RS09390	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TSC_RS09400	COG1085	galactose-1-phosphate uridylyltransferase
TSC_RS09405	COG3345	alpha-galactosidase
TSC_RS09410	COG2211	Major facilitator Superfamily
TSC_RS09415	COG3250	beta-galactosidase activity
TSC_RS09430	COG2211	Major facilitator Superfamily
TSC_RS09440	COG1181	Belongs to the D-alanine--D-alanine ligase family
TSC_RS09445	COG0193	aminoacyl-tRNA hydrolase activity
TSC_RS09450	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TSC_RS09455	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TSC_RS09460	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TSC_RS09465	COG1854	S-ribosylhomocysteine lyase activity
TSC_RS09470	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TSC_RS09470	COG0519	Catalyzes the synthesis of GMP from XMP
TSC_RS09475	COG4636	protein conserved in cyanobacteria
TSC_RS09480	COG4274	PFAM GYD family protein
TSC_RS09495	COG0328	RNA-DNA hybrid ribonuclease activity
TSC_RS09500	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TSC_RS09555	COG0366	Alpha amylase catalytic
TSC_RS09585	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TSC_RS09590	COG0460	homoserine dehydrogenase
TSC_RS09595	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TSC_RS09630	COG0037	tRNA processing
TSC_RS09635	COG2104	thiamine diphosphate biosynthetic process
TSC_RS09640	COG0123	including yeast histone deacetylase and acetoin utilization protein
TSC_RS09645	COG0517	IMP dehydrogenase activity
TSC_RS09655	COG0444	Belongs to the ABC transporter superfamily
TSC_RS09660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSC_RS09665	COG0601	transmembrane transport
TSC_RS09670	COG0747	negative chemotaxis
TSC_RS09675	COG0604	alcohol dehydrogenase
TSC_RS09680	COG0492	ferredoxin-NADP+ reductase activity
TSC_RS09720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TSC_RS09725	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TSC_RS09730	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TSC_RS09750	COG2070	2-Nitropropane dioxygenase
TSC_RS09770	COG0745	RESPONSE REGULATOR receiver
TSC_RS09775	COG5002	protein histidine kinase activity
TSC_RS09795	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TSC_RS09805	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TSC_RS09820	COG0513	Belongs to the DEAD box helicase family
TSC_RS09825	COG0303	'Molybdopterin
TSC_RS09845	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TSC_RS09850	COG0442	prolyl-tRNA aminoacylation
TSC_RS09860	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TSC_RS09865	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TSC_RS09880	COG1028	Short-chain dehydrogenase reductase Sdr
TSC_RS09885	COG2816	NAD+ diphosphatase activity
TSC_RS09895	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TSC_RS09900	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TSC_RS09910	COG1482	cell wall glycoprotein biosynthetic process
TSC_RS09920	COG1515	deoxyribonuclease V activity
TSC_RS09930	COG0776	regulation of translation
TSC_RS09935	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TSC_RS09940	COG0443	Heat shock 70 kDa protein
TSC_RS09945	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TSC_RS09950	COG0484	heat shock protein binding
TSC_RS09955	COG0789	Transcriptional regulator
TSC_RS09960	COG0542	response to heat
TSC_RS10000	COG0490	domain, Protein
TSC_RS10005	COG0475	glutathione-regulated potassium exporter activity
TSC_RS10020	COG3620	sequence-specific DNA binding
TSC_RS10020	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TSC_RS10020	COG0617	tRNA 3'-terminal CCA addition
TSC_RS10025	COG0475	glutathione-regulated potassium exporter activity
TSC_RS10045	COG0067	glutamate synthase
TSC_RS10045	COG0069	glutamate synthase activity
TSC_RS10045	COG0070	glutamate synthase
TSC_RS10050	COG0247	lactate metabolic process
TSC_RS10055	COG1139	Iron-sulfur cluster binding protein
TSC_RS10060	COG1139	Iron-sulfur cluster binding protein
TSC_RS10065	COG0681	Belongs to the peptidase S26 family
TSC_RS10070	COG1752	Esterase of the alpha-beta hydrolase superfamily
TSC_RS10075	COG2815	serine threonine protein kinase
TSC_RS10075	COG0515	serine threonine protein kinase
TSC_RS10095	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TSC_RS10115	COG2199	diguanylate cyclase activity
TSC_RS10115	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TSC_RS10125	COG0473	3-isopropylmalate dehydrogenase activity
TSC_RS10150	COG1450	Type ii and iii secretion system protein
TSC_RS10155	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TSC_RS10160	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TSC_RS10165	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TSC_RS10175	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TSC_RS10175	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TSC_RS10180	COG0736	holo-[acyl-carrier-protein] synthase activity
TSC_RS10195	COG1160	GTP binding
TSC_RS10210	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TSC_RS10215	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TSC_RS10215	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TSC_RS10220	COG0083	homoserine kinase activity
TSC_RS10235	COG0268	Binds directly to 16S ribosomal RNA
TSC_RS10245	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TSC_RS10250	COG0723	plastoquinol--plastocyanin reductase activity
TSC_RS10260	COG3088	subunit of a heme lyase
TSC_RS10260	COG4235	cytochrome complex assembly
TSC_RS10265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TSC_RS10270	COG1138	Cytochrome C-type biogenesis protein
TSC_RS10275	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TSC_RS10280	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TSC_RS10290	COG4133	protoheme IX ABC transporter activity
TSC_RS10295	COG0785	Cytochrome C biogenesis protein
TSC_RS10305	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TSC_RS10310	COG0446	pyridine nucleotide-disulphide oxidoreductase
TSC_RS10325	COG3258	Cytochrome c
TSC_RS10330	COG2010	Cytochrome c
TSC_RS10335	COG0737	Belongs to the 5'-nucleotidase family
TSC_RS10340	COG2010	Cytochrome c
TSC_RS10345	COG3258	Cytochrome c
TSC_RS10365	COG2010	Cytochrome c
TSC_RS10370	COG3842	ATPase activity
TSC_RS10390	COG0504	CTP synthase activity
TSC_RS10395	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TSC_RS10400	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TSC_RS10425	COG2205	protein histidine kinase activity
TSC_RS10435	COG2815	serine threonine protein kinase
TSC_RS10435	COG0515	serine threonine protein kinase
TSC_RS10440	COG0631	protein serine/threonine phosphatase activity
TSC_RS10455	COG0113	porphobilinogen synthase activity
TSC_RS10460	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TSC_RS10465	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TSC_RS10490	COG1506	peptidase
TSC_RS10490	COG4946	Tricorn protease homolog
TSC_RS10490	COG0823	Involved in the tonB-independent uptake of proteins
TSC_RS10495	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TSC_RS10500	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TSC_RS10525	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TSC_RS10530	COG1011	Hydrolase
TSC_RS10540	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TSC_RS10555	COG0537	adenosine 5'-monophosphoramidase activity
TSC_RS10560	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TSC_RS10570	COG0135	phosphoribosylanthranilate isomerase activity
TSC_RS10575	COG0483	inositol monophosphate 1-phosphatase activity
TSC_RS10585	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
TSC_RS10590	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TSC_RS10595	COG0714	Associated with various cellular activities
TSC_RS10600	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TSC_RS10600	COG0574	Belongs to the PEP-utilizing enzyme family
TSC_RS10605	COG1272	protein, Hemolysin III
TSC_RS10615	COG3850	Histidine kinase
TSC_RS10615	COG5002	protein histidine kinase activity
TSC_RS10650	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TSC_RS10665	COG0546	phosphoglycolate phosphatase activity
TSC_RS10680	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TSC_RS10695	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TSC_RS10705	COG0047	phosphoribosylformylglycinamidine synthase activity
TSC_RS10715	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TSC_RS10720	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TSC_RS10730	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TSC_RS10735	COG0497	DNA recombination
TSC_RS10745	COG2095	MarC family integral membrane protein
TSC_RS10750	COG1438	arginine binding
TSC_RS10755	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TSC_RS10765	COG0194	GDP metabolic process
TSC_RS10775	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TSC_RS10780	COG2385	sporulation resulting in formation of a cellular spore
TSC_RS10785	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
TSC_RS10795	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TSC_RS10825	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TSC_RS10830	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TSC_RS10835	COG0142	geranyltranstransferase activity
TSC_RS10850	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TSC_RS10880	COG0203	ribosomal protein L17
TSC_RS10890	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TSC_RS10895	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TSC_RS10900	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TSC_RS10910	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TSC_RS10920	COG0563	adenylate kinase activity
TSC_RS10925	COG0201	protein transport
TSC_RS10985	COG0255	Belongs to the universal ribosomal protein uL29 family
TSC_RS10990	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TSC_RS10995	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TSC_RS11005	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TSC_RS11010	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TSC_RS11015	COG0089	rRNA binding
TSC_RS11020	COG0088	Forms part of the polypeptide exit tunnel
TSC_RS11030	COG0051	transcription antitermination factor activity, RNA binding
TSC_RS11045	COG0049	tRNA binding
TSC_RS11070	COG1461	Dihydroxyacetone kinase
TSC_RS11080	COG0686	Belongs to the AlaDH PNT family
TSC_RS11085	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TSC_RS11090	COG1024	Enoyl-CoA hydratase
TSC_RS11095	COG1187	pseudouridine synthase activity
TSC_RS11100	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TSC_RS11110	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TSC_RS11120	COG0512	Glutamine amidotransferase of anthranilate synthase
TSC_RS11125	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TSC_RS11130	COG1012	belongs to the aldehyde dehydrogenase family
TSC_RS11135	COG0506	proline dehydrogenase activity
TSC_RS11140	COG1802	Transcriptional regulator
TSC_RS11150	COG0156	8-amino-7-oxononanoate synthase activity
TSC_RS11165	COG0187	DNA topoisomerase II activity
TSC_RS11170	COG1643	Atp-dependent helicase
TSC_RS11180	COG1063	alcohol dehydrogenase
TSC_RS11235	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TSC_RS11235	COG1605	Chorismate mutase
TSC_RS11240	COG0805	protein transport
TSC_RS11245	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TSC_RS11250	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TSC_RS11255	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TSC_RS11275	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TSC_RS11280	COG0792	nuclease activity
TSC_RS11290	COG0492	ferredoxin-NADP+ reductase activity
TSC_RS11295	COG1028	Short-chain dehydrogenase reductase Sdr
TSC_RS11300	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TSC_RS11315	COG1187	pseudouridine synthase activity
TSC_RS11320	COG2720	vancomycin resistance protein
TSC_RS11330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TSC_RS11335	COG0427	acetyl-CoA hydrolase
TSC_RS11340	COG0686	Belongs to the AlaDH PNT family
TSC_RS11355	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TSC_RS11360	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TSC_RS11365	COG0071	Belongs to the small heat shock protein (HSP20) family
TSC_RS11375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TSC_RS11385	COG1764	response to oxidative stress
TSC_RS11395	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TSC_RS11410	COG3842	ATPase activity
TSC_RS11415	COG0101	tRNA pseudouridine synthase activity
TSC_RS11420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSC_RS11425	COG0601	transmembrane transport
TSC_RS11435	COG0316	Belongs to the HesB IscA family
TSC_RS11445	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TSC_RS11460	COG1166	arginine decarboxylase activity
TSC_RS11470	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TSC_RS11475	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TSC_RS11485	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TSC_RS11510	COG0366	Alpha amylase catalytic
TSC_RS11540	COG2226	methyltransferase
TSC_RS11545	COG4603	Belongs to the binding-protein-dependent transport system permease family
TSC_RS11550	COG1079	Belongs to the binding-protein-dependent transport system permease family
TSC_RS11560	COG1774	PSP1 C-terminal conserved region
TSC_RS11565	COG0470	DNA polymerase III
TSC_RS11600	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TSC_RS11615	COG1653	transport
TSC_RS11635	COG0723	plastoquinol--plastocyanin reductase activity
TSC_RS11640	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TSC_RS11645	COG0539	negative regulation of cytoplasmic translation
TSC_RS11675	COG1115	amino acid carrier protein
TSC_RS11725	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TSC_RS11730	COG1355	regulation of microtubule-based process
TSC_RS11745	COG1011	Hydrolase
TSC_RS11760	COG0589	response to stress
TSC_RS11765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TSC_RS11770	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TSC_RS11780	COG1940	carbohydrate kinase activity
TSC_RS11825	COG0302	gtp cyclohydrolase
TSC_RS11845	COG1217	gtp-binding protein TYPA
TSC_RS11870	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TSC_RS11885	COG0395	ABC-type sugar transport system, permease component
TSC_RS11890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TSC_RS11895	COG1131	(ABC) transporter
TSC_RS11915	COG0556	nucleotide-excision repair
TSC_RS11925	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TSC_RS11985	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TSC_RS11990	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TSC_RS12030	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TSC_RS12035	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TSC_RS12040	COG0343	queuine tRNA-ribosyltransferase activity
TSC_RS12045	COG0628	permease
TSC_RS12055	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TSC_RS12060	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TSC_RS12070	COG0436	Aminotransferase
TSC_RS12080	COG1597	lipid kinase activity
TSC_RS12095	COG0123	including yeast histone deacetylase and acetoin utilization protein
TSC_RS12100	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TSC_RS12110	COG0004	ammonium transporteR
TSC_RS12115	COG0347	Belongs to the P(II) protein family
TSC_RS12120	COG1420	regulation of RNA biosynthetic process
TSC_RS12125	COG0314	molybdopterin synthase activity
TSC_RS12135	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TSC_RS12140	COG1960	acyl-CoA dehydrogenase activity
TSC_RS12150	COG0495	leucyl-tRNA aminoacylation
TSC_RS12160	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TSC_RS12165	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TSC_RS12180	COG2096	Adenosyltransferase
TSC_RS12190	COG4555	ABC transporter
TSC_RS12195	COG1668	transmembrane transport
TSC_RS12220	COG1660	Displays ATPase and GTPase activities
TSC_RS12225	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TSC_RS12240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TSC_RS12245	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TSC_RS12265	COG0072	phenylalanine-tRNA ligase activity
TSC_RS12265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TSC_RS12275	COG0205	6-phosphofructokinase activity
TSC_RS12280	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TSC_RS12290	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TSC_RS12295	COG0584	glycerophosphoryl diester phosphodiesterase
TSC_RS12315	COG1475	DNA binding
TSC_RS12320	COG1192	Involved in chromosome partitioning
TSC_RS12325	COG0357	Ribosomal RNA small subunit methyltransferase G
TSC_RS12330	COG0445	tRNA wobble uridine modification
TSC_RS12345	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TSC_RS12360	COG0592	DNA-directed DNA polymerase activity
TSC_RS12365	COG0148	phosphopyruvate hydratase activity
TSC_RS12375	COG0469	pyruvate kinase activity
TSC_RS12425	COG1193	negative regulation of DNA recombination
TSC_RS12440	COG3300	MHYT domain
TSC_RS12440	COG5001	Diguanylate cyclase
TSC_RS12475	COG0542	response to heat