locus-tag	class	description
EBI04_RS00005	COG0704	Plays a role in the regulation of phosphate uptake
EBI04_RS00010	COG2205	protein histidine kinase activity
EBI04_RS00015	COG0745	RESPONSE REGULATOR receiver
EBI04_RS00030	COG0281	malic enzyme
EBI04_RS00045	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EBI04_RS00050	COG0509	glycine decarboxylation via glycine cleavage system
EBI04_RS00055	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EBI04_RS00060	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EBI04_RS00080	COG0243	molybdopterin cofactor binding
EBI04_RS00090	COG2197	response regulator
EBI04_RS00100	COG0196	riboflavin kinase activity
EBI04_RS00105	COG0494	nUDIX hydrolase
EBI04_RS00135	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EBI04_RS00145	COG0358	DNA primase activity
EBI04_RS00165	COG0456	acetyltransferase
EBI04_RS00175	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EBI04_RS00180	COG0009	L-threonylcarbamoyladenylate synthase
EBI04_RS00185	COG1459	type II secretion system
EBI04_RS00200	COG0277	FAD linked oxidase domain protein
EBI04_RS00210	COG0287	Prephenate dehydrogenase
EBI04_RS00215	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EBI04_RS00220	COG2514	catechol 2,3-dioxygenase activity
EBI04_RS00225	COG2353	YceI-like domain
EBI04_RS00230	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
EBI04_RS00235	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EBI04_RS00255	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EBI04_RS00260	COG0179	Fumarylacetoacetate (FAA) hydrolase
EBI04_RS00270	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EBI04_RS00275	COG0151	Belongs to the GarS family
EBI04_RS00285	COG0745	RESPONSE REGULATOR receiver
EBI04_RS00290	COG2205	protein histidine kinase activity
EBI04_RS00295	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EBI04_RS00295	COG0617	tRNA 3'-terminal CCA addition
EBI04_RS00295	COG0517	IMP dehydrogenase activity
EBI04_RS00305	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EBI04_RS00315	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EBI04_RS00320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EBI04_RS00325	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EBI04_RS00335	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EBI04_RS00335	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EBI04_RS00340	COG1733	regulation of RNA biosynthetic process
EBI04_RS00345	COG2894	cell division
EBI04_RS00350	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EBI04_RS00355	COG0772	Belongs to the SEDS family
EBI04_RS00360	COG3842	ATPase activity
EBI04_RS00365	COG1176	ABC-type spermidine putrescine transport system, permease component I
EBI04_RS00370	COG1177	transmembrane transport
EBI04_RS00375	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EBI04_RS00380	COG2010	Cytochrome c
EBI04_RS00385	COG0129	dihydroxy-acid dehydratase activity
EBI04_RS00410	COG0066	3-isopropylmalate dehydratase activity
EBI04_RS00415	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EBI04_RS00430	COG0180	Tryptophanyl-tRNA synthetase
EBI04_RS00470	COG1091	dTDP-4-dehydrorhamnose reductase activity
EBI04_RS00505	COG2165	general secretion pathway protein
EBI04_RS00515	COG4966	pilus assembly protein PilW
EBI04_RS00520	COG2165	general secretion pathway protein
EBI04_RS00525	COG4970	Tfp pilus assembly protein FimT
EBI04_RS00530	COG4970	Tfp pilus assembly protein FimT
EBI04_RS00535	COG0183	Belongs to the thiolase family
EBI04_RS00550	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
EBI04_RS00555	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EBI04_RS00570	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EBI04_RS00575	COG1254	Belongs to the acylphosphatase family
EBI04_RS00585	COG1063	alcohol dehydrogenase
EBI04_RS00590	COG2133	pyrroloquinoline quinone binding
EBI04_RS00595	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EBI04_RS00630	COG0419	ATPase involved in DNA repair
EBI04_RS00655	COG0612	Peptidase, M16
EBI04_RS00660	COG0612	Peptidase, M16
EBI04_RS00665	COG0697	spore germination
EBI04_RS00670	COG1250	3-hydroxyacyl-CoA dehydrogenase
EBI04_RS00695	COG4956	integral membrane protein (PIN domain superfamily)
EBI04_RS00700	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EBI04_RS00705	COG0542	response to heat
EBI04_RS00725	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EBI04_RS00745	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EBI04_RS00745	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EBI04_RS00750	COG1024	Enoyl-CoA hydratase
EBI04_RS00755	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EBI04_RS00765	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EBI04_RS00775	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EBI04_RS00780	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EBI04_RS00785	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EBI04_RS00795	COG0861	Integral membrane protein TerC family
EBI04_RS00800	COG0492	ferredoxin-NADP+ reductase activity
EBI04_RS00810	COG0028	Belongs to the TPP enzyme family
EBI04_RS00815	COG0440	acetolactate synthase activity
EBI04_RS00820	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EBI04_RS00830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EBI04_RS00845	COG4555	ABC transporter
EBI04_RS00885	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EBI04_RS00900	COG1316	TRANSCRIPTIONal
EBI04_RS00935	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EBI04_RS00955	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EBI04_RS00965	COG1269	ATP hydrolysis coupled proton transport
EBI04_RS00975	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
EBI04_RS00980	COG1527	subunit (C
EBI04_RS00985	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
EBI04_RS00990	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
EBI04_RS00995	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
EBI04_RS01000	COG1394	ATPase activity, coupled to movement of substances
EBI04_RS01005	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EBI04_RS01055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EBI04_RS01065	COG1760	l-serine dehydratase
EBI04_RS01075	COG0481	GTPase activity
EBI04_RS01085	COG1960	acyl-CoA dehydrogenase activity
EBI04_RS01090	COG0183	Belongs to the thiolase family
EBI04_RS01105	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EBI04_RS01110	COG1028	Short-chain dehydrogenase reductase Sdr
EBI04_RS01165	COG0559	Belongs to the binding-protein-dependent transport system permease family
EBI04_RS01180	COG2030	dehydratase
EBI04_RS01190	COG0596	Alpha beta hydrolase
EBI04_RS01200	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EBI04_RS01245	COG2909	trisaccharide binding
EBI04_RS01255	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EBI04_RS01255	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EBI04_RS01265	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EBI04_RS01275	COG0195	Participates in both transcription termination and antitermination
EBI04_RS01280	COG0779	Required for maturation of 30S ribosomal subunits
EBI04_RS01290	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EBI04_RS01290	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EBI04_RS01300	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EBI04_RS01300	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EBI04_RS01320	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EBI04_RS01320	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EBI04_RS01325	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EBI04_RS01325	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EBI04_RS01330	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EBI04_RS01350	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EBI04_RS01355	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EBI04_RS01360	COG1702	phosphate starvation-inducible protein PhoH
EBI04_RS01370	COG4864	UPF0365 protein
EBI04_RS01380	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EBI04_RS01410	COG2814	Major facilitator Superfamily
EBI04_RS01420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EBI04_RS01425	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EBI04_RS01430	COG0824	Thioesterase
EBI04_RS01440	COG0557	exoribonuclease II activity
EBI04_RS01445	COG1355	regulation of microtubule-based process
EBI04_RS01450	COG0617	tRNA 3'-terminal CCA addition
EBI04_RS01450	COG1353	crispr-associated protein
EBI04_RS01455	COG0237	dephospho-CoA kinase activity
EBI04_RS01470	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EBI04_RS01505	COG0165	Argininosuccinate lyase
EBI04_RS01530	COG2239	Acts as a magnesium transporter
EBI04_RS01535	COG0530	calcium, potassium:sodium antiporter activity
EBI04_RS01545	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EBI04_RS01550	COG1185	polyribonucleotide nucleotidyltransferase activity
EBI04_RS01555	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EBI04_RS01570	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EBI04_RS01575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EBI04_RS01585	COG1100	Small GTP-binding protein
EBI04_RS01615	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EBI04_RS01620	COG0511	ligase activity, forming carbon-carbon bonds
EBI04_RS01625	COG0439	Biotin carboxylase
EBI04_RS01640	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EBI04_RS01645	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
EBI04_RS01655	COG0247	lactate metabolic process
EBI04_RS01655	COG2181	nitrate reductase activity
EBI04_RS01665	COG0861	Integral membrane protein TerC family
EBI04_RS01670	COG2819	hydrolase of the alpha beta superfamily
EBI04_RS01680	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EBI04_RS01685	COG0438	transferase activity, transferring glycosyl groups
EBI04_RS01720	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EBI04_RS01725	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EBI04_RS01735	COG0243	molybdopterin cofactor binding
EBI04_RS01735	COG3383	formate dehydrogenase (NAD+) activity
EBI04_RS01740	COG0437	4 iron, 4 sulfur cluster binding
EBI04_RS01755	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EBI04_RS01760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EBI04_RS01785	COG3845	ABC transporter
EBI04_RS01790	COG4603	Belongs to the binding-protein-dependent transport system permease family
EBI04_RS01795	COG1079	Belongs to the binding-protein-dependent transport system permease family
EBI04_RS01805	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EBI04_RS01810	COG0494	nUDIX hydrolase
EBI04_RS01820	COG0138	bifunctional purine biosynthesis protein purh
EBI04_RS01830	COG2337	Toxic component of a toxin-antitoxin (TA) module
EBI04_RS01835	COG3239	Fatty acid desaturase
EBI04_RS01845	COG1490	D-aminoacyl-tRNA deacylase activity
EBI04_RS01850	COG1307	EDD domain protein, DegV family
EBI04_RS01855	COG1307	EDD domain protein, DegV family
EBI04_RS01860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EBI04_RS01875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EBI04_RS01885	COG1012	belongs to the aldehyde dehydrogenase family
EBI04_RS01890	COG2368	4-hydroxyphenylacetate
EBI04_RS01930	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
EBI04_RS01940	COG1492	cobalamin metabolic process
EBI04_RS01945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EBI04_RS01955	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EBI04_RS01955	COG0574	Belongs to the PEP-utilizing enzyme family
EBI04_RS01960	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EBI04_RS01985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EBI04_RS02000	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EBI04_RS02010	COG0601	transmembrane transport
EBI04_RS02020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EBI04_RS02030	COG2226	methyltransferase
EBI04_RS02040	COG0601	transmembrane transport
EBI04_RS02045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EBI04_RS02050	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EBI04_RS02055	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EBI04_RS02060	COG2188	Transcriptional regulator
EBI04_RS02065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EBI04_RS02070	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EBI04_RS02075	COG1472	Belongs to the glycosyl hydrolase 3 family
EBI04_RS02085	COG1175	transmembrane transport
EBI04_RS02090	COG0395	ABC-type sugar transport system, permease component
EBI04_RS02095	COG0019	diaminopimelate decarboxylase activity
EBI04_RS02110	COG0745	RESPONSE REGULATOR receiver
EBI04_RS02135	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EBI04_RS02150	COG0589	response to stress
EBI04_RS02155	COG1993	acr, cog1993
EBI04_RS02170	COG1193	negative regulation of DNA recombination
EBI04_RS02175	COG1193	negative regulation of DNA recombination
EBI04_RS02185	COG2205	protein histidine kinase activity
EBI04_RS02200	COG2010	Cytochrome c
EBI04_RS02205	COG1914	H( )-stimulated, divalent metal cation uptake system
EBI04_RS02230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EBI04_RS02235	COG0642	Histidine kinase
EBI04_RS02245	COG0671	phosphoesterase, PA-phosphatase related
EBI04_RS02260	COG2323	membrane
EBI04_RS02275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EBI04_RS02285	COG3258	Cytochrome c
EBI04_RS02290	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EBI04_RS02300	COG0363	glucosamine-6-phosphate deaminase activity
EBI04_RS02310	COG0723	plastoquinol--plastocyanin reductase activity
EBI04_RS02315	COG0730	response to heat
EBI04_RS02355	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
EBI04_RS02355	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
EBI04_RS02375	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
EBI04_RS02395	COG0588	phosphoglycerate mutase activity
EBI04_RS02405	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EBI04_RS02410	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
EBI04_RS02420	COG1797	cobyrinic acid a,c-diamide synthase activity
EBI04_RS02425	COG2046	Belongs to the sulfate adenylyltransferase family
EBI04_RS02430	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EBI04_RS02430	COG1648	precorrin-2 dehydrogenase activity
EBI04_RS02435	COG0730	response to heat
EBI04_RS02440	COG0175	sulfate reduction
EBI04_RS02445	COG1648	precorrin-2 dehydrogenase activity
EBI04_RS02445	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EBI04_RS02450	COG1587	Uroporphyrinogen-III synthase
EBI04_RS02460	COG0352	thiamine-phosphate diphosphorylase activity
EBI04_RS02465	COG2104	thiamine diphosphate biosynthetic process
EBI04_RS02470	COG2022	thiamine diphosphate biosynthetic process
EBI04_RS02475	COG2022	thiamine diphosphate biosynthetic process
EBI04_RS02475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EBI04_RS02480	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EBI04_RS02495	COG0351	phosphomethylpyrimidine kinase
EBI04_RS02500	COG1028	Short-chain dehydrogenase reductase Sdr
EBI04_RS02505	COG0318	PFAM AMP-dependent synthetase and ligase
EBI04_RS02510	COG1012	belongs to the aldehyde dehydrogenase family
EBI04_RS02510	COG2030	dehydratase
EBI04_RS02515	COG1960	acyl-CoA dehydrogenase activity
EBI04_RS02520	COG1309	transcriptional regulator
EBI04_RS02525	COG1980	fructose-bisphosphate aldolase activity
EBI04_RS02550	COG2186	Transcriptional regulator
EBI04_RS02555	COG0747	negative chemotaxis
EBI04_RS02565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EBI04_RS02580	COG0395	ABC-type sugar transport system, permease component
EBI04_RS02595	COG1609	Transcriptional regulator
EBI04_RS02605	COG1607	acyl-coa hydrolase
EBI04_RS02610	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EBI04_RS02625	COG1378	Sugar-specific transcriptional regulator TrmB
EBI04_RS02630	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EBI04_RS02635	COG0022	dehydrogenase e1 component
EBI04_RS02645	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EBI04_RS02655	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EBI04_RS02655	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EBI04_RS02665	COG1349	DNA-binding transcription factor activity
EBI04_RS02670	COG0434	BtpA family
EBI04_RS02675	COG1070	Carbohydrate kinase
EBI04_RS02695	COG1175	transmembrane transport
EBI04_RS02700	COG3842	ATPase activity
EBI04_RS02705	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EBI04_RS02715	COG1178	ABC-type Fe3 transport system permease component
EBI04_RS02720	COG1177	transmembrane transport
EBI04_RS02730	COG1692	metallophosphoesterase
EBI04_RS02735	COG0395	ABC-type sugar transport system, permease component
EBI04_RS02740	COG1175	transmembrane transport
EBI04_RS02750	COG3842	ATPase activity
EBI04_RS02765	COG1653	transport
EBI04_RS02770	COG0395	ABC-type sugar transport system, permease component
EBI04_RS02775	COG1175	transmembrane transport
EBI04_RS02785	COG0803	Belongs to the bacterial solute-binding protein 9 family
EBI04_RS02795	COG0463	Glycosyl transferase, family 2
EBI04_RS02810	COG0395	ABC-type sugar transport system, permease component
EBI04_RS02815	COG1175	transmembrane transport
EBI04_RS02840	COG1785	Belongs to the alkaline phosphatase family
EBI04_RS02845	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EBI04_RS02850	COG1126	abc transporter atp-binding protein
EBI04_RS02855	COG0765	amino acid transport
EBI04_RS02860	COG4597	amino acid ABC transporter
EBI04_RS02865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EBI04_RS02870	COG0829	nickel cation binding
EBI04_RS02875	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EBI04_RS02880	COG0830	nickel cation binding
EBI04_RS02885	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
EBI04_RS02890	COG0804	urea catabolic process
EBI04_RS02895	COG0831	urea catabolic process
EBI04_RS02895	COG0832	Belongs to the urease beta subunit family
EBI04_RS02905	COG0831	urea catabolic process
EBI04_RS02965	COG0494	nUDIX hydrolase
EBI04_RS03005	COG1131	(ABC) transporter
EBI04_RS03035	COG3396	Phenylacetate-CoA oxygenase
EBI04_RS03055	COG1012	belongs to the aldehyde dehydrogenase family
EBI04_RS03055	COG2030	dehydratase
EBI04_RS03060	COG1733	regulation of RNA biosynthetic process
EBI04_RS03065	COG2193	ferroxidase activity
EBI04_RS03075	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EBI04_RS03090	COG1331	Highly conserved protein containing a thioredoxin domain
EBI04_RS03100	COG0183	Belongs to the thiolase family
EBI04_RS03105	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EBI04_RS03110	COG0477	Major facilitator Superfamily
EBI04_RS03120	COG1960	acyl-CoA dehydrogenase activity
EBI04_RS03125	COG2414	aldehyde ferredoxin oxidoreductase
EBI04_RS03140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EBI04_RS03145	COG0803	Belongs to the bacterial solute-binding protein 9 family
EBI04_RS03150	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EBI04_RS03155	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EBI04_RS03165	COG3383	formate dehydrogenase (NAD+) activity
EBI04_RS03170	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EBI04_RS03180	COG5002	protein histidine kinase activity
EBI04_RS03185	COG1960	acyl-CoA dehydrogenase activity
EBI04_RS03190	COG2086	electron transfer activity
EBI04_RS03195	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EBI04_RS03205	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EBI04_RS03225	COG1573	uracil-dna glycosylase
EBI04_RS03230	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EBI04_RS03230	COG1796	DNA polymerase
EBI04_RS03245	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EBI04_RS03245	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EBI04_RS03245	COG0674	pyruvate-flavodoxin oxidoreductase activity
EBI04_RS03245	COG1013	pyruvate-flavodoxin oxidoreductase activity
EBI04_RS03255	COG2873	o-acetylhomoserine
EBI04_RS03270	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EBI04_RS03275	COG0215	cysteine-tRNA ligase activity
EBI04_RS03280	COG1960	acyl-CoA dehydrogenase activity
EBI04_RS03285	COG0183	Belongs to the thiolase family
EBI04_RS03290	COG1024	Enoyl-CoA hydratase
EBI04_RS03290	COG1250	3-hydroxyacyl-CoA dehydrogenase
EBI04_RS03320	COG0438	transferase activity, transferring glycosyl groups
EBI04_RS03325	COG0438	transferase activity, transferring glycosyl groups
EBI04_RS03335	COG1215	transferase activity, transferring glycosyl groups
EBI04_RS03350	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EBI04_RS03350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EBI04_RS03355	COG1811	Na channel or pump
EBI04_RS03360	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EBI04_RS03365	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EBI04_RS03370	COG4948	Mandelate Racemase Muconate Lactonizing
EBI04_RS03380	COG0402	S-adenosylhomocysteine deaminase activity
EBI04_RS03410	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EBI04_RS03415	COG0742	ribosomal rna small subunit methyltransferase
EBI04_RS03430	COG2873	o-acetylhomoserine
EBI04_RS03435	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EBI04_RS03445	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EBI04_RS03465	COG0149	triose-phosphate isomerase activity
EBI04_RS03470	COG0126	phosphoglycerate kinase activity
EBI04_RS03480	COG1268	BioY protein
EBI04_RS03490	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EBI04_RS03505	COG1196	nuclear chromosome segregation
EBI04_RS03515	COG0450	alkyl hydroperoxide reductase
EBI04_RS03525	COG2738	Putative neutral zinc metallopeptidase
EBI04_RS03530	COG2897	thiosulfate sulfurtransferase activity
EBI04_RS03535	COG1760	l-serine dehydratase
EBI04_RS03540	COG2197	response regulator
EBI04_RS03545	COG0335	large ribosomal subunit rRNA binding
EBI04_RS03550	COG0336	Belongs to the RNA methyltransferase TrmD family
EBI04_RS03555	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EBI04_RS03565	COG0228	four-way junction DNA binding
EBI04_RS03575	COG2239	Acts as a magnesium transporter
EBI04_RS03585	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EBI04_RS03630	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EBI04_RS03635	COG1410	methionine synthase
EBI04_RS03635	COG0646	methionine synthase
EBI04_RS03640	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EBI04_RS03645	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EBI04_RS03650	COG0740	serine-type endopeptidase activity
EBI04_RS03655	COG0544	peptidyl-prolyl cis-trans isomerase activity
EBI04_RS03675	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EBI04_RS03680	COG3870	Protein conserved in bacteria
EBI04_RS03685	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EBI04_RS03695	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EBI04_RS03705	COG4475	Protein of unknown function (DUF436)
EBI04_RS03720	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EBI04_RS03720	COG0649	NAD binding
EBI04_RS03720	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EBI04_RS03725	COG0651	ATP synthesis coupled electron transport
EBI04_RS03740	COG0651	ATP synthesis coupled electron transport
EBI04_RS03760	COG3842	ATPase activity
EBI04_RS03765	COG0572	uridine kinase
EBI04_RS03785	COG2176	DNA-directed DNA polymerase activity
EBI04_RS03790	COG0154	amidase activity
EBI04_RS03795	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EBI04_RS03805	COG1435	thymidine kinase activity
EBI04_RS03815	COG0254	rRNA binding
EBI04_RS03830	COG2001	Belongs to the MraZ family
EBI04_RS03835	COG0275	rRNA processing
EBI04_RS03845	COG0768	penicillin binding
EBI04_RS03850	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EBI04_RS03860	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EBI04_RS03865	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EBI04_RS03870	COG0772	Belongs to the SEDS family
EBI04_RS03875	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EBI04_RS03880	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EBI04_RS03885	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EBI04_RS03905	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EBI04_RS03925	COG2391	methyltransferase activity
EBI04_RS03930	COG1090	epimerase
EBI04_RS03935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EBI04_RS03945	COG1562	ergosterol biosynthetic process
EBI04_RS03950	COG0415	Belongs to the DNA photolyase family
EBI04_RS03985	COG1304	FMN binding
EBI04_RS04035	COG1028	Short-chain dehydrogenase reductase Sdr
EBI04_RS04070	COG1175	transmembrane transport
EBI04_RS04075	COG0395	ABC-type sugar transport system, permease component
EBI04_RS04100	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EBI04_RS04105	COG2264	protein methyltransferase activity
EBI04_RS04115	COG0489	protein tyrosine kinase activity
EBI04_RS04125	COG0525	valine-tRNA ligase activity
EBI04_RS04135	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EBI04_RS04145	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EBI04_RS04185	COG0134	indole-3-glycerol-phosphate synthase activity
EBI04_RS04190	COG1752	Esterase of the alpha-beta hydrolase superfamily
EBI04_RS04210	COG2358	TRAP transporter, solute receptor (TAXI family
EBI04_RS04215	COG0765	amino acid transport
EBI04_RS04220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EBI04_RS04230	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EBI04_RS04235	COG0569	domain protein
EBI04_RS04240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EBI04_RS04250	COG2313	pseudouridylate synthase activity
EBI04_RS04260	COG3001	Fructosamine kinase
EBI04_RS04265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EBI04_RS04270	COG4585	Histidine kinase
EBI04_RS04295	COG0012	GTP binding
EBI04_RS04310	COG0424	maF-like protein
EBI04_RS04325	COG0768	penicillin binding
EBI04_RS04335	COG2322	membrane
EBI04_RS04355	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EBI04_RS04360	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EBI04_RS04370	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EBI04_RS04385	COG3842	ATPase activity
EBI04_RS04395	COG0124	histidyl-tRNA synthetase
EBI04_RS04405	COG0384	phenazine biosynthesis protein PhzF
EBI04_RS04410	COG0561	phosphatase activity
EBI04_RS04415	COG0017	Asparaginyl-tRNA synthetase
EBI04_RS04420	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
EBI04_RS04425	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EBI04_RS04430	COG2217	Heavy metal translocating P-type atpase
EBI04_RS04435	COG0640	Transcriptional regulator
EBI04_RS04440	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
EBI04_RS04445	COG0739	heme binding
EBI04_RS04450	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EBI04_RS04460	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EBI04_RS04465	COG0006	proline dipeptidase activity
EBI04_RS04470	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EBI04_RS04475	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EBI04_RS04480	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EBI04_RS04515	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EBI04_RS04525	COG1994	Peptidase M50
EBI04_RS04535	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EBI04_RS04535	COG0617	tRNA 3'-terminal CCA addition
EBI04_RS04535	COG0517	IMP dehydrogenase activity
EBI04_RS04590	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EBI04_RS04610	COG4970	Tfp pilus assembly protein FimT
EBI04_RS04655	COG0542	response to heat
EBI04_RS04665	COG2860	membrane
EBI04_RS04720	COG1475	DNA binding
EBI04_RS04745	COG4712	double-strand break repair protein
EBI04_RS04755	COG0210	DNA helicase
EBI04_RS04770	COG3864	Putative metallopeptidase domain
EBI04_RS04775	COG0714	Associated with various cellular activities
EBI04_RS04920	COG0750	zinc metalloprotease
EBI04_RS04975	COG0582	viral genome integration into host DNA
EBI04_RS04985	COG0052	Belongs to the universal ribosomal protein uS2 family
EBI04_RS04990	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EBI04_RS04995	COG0528	UMP kinase activity
EBI04_RS05005	COG4589	Belongs to the CDS family
EBI04_RS05010	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EBI04_RS05015	COG0750	zinc metalloprotease
EBI04_RS05030	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EBI04_RS05035	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EBI04_RS05040	COG2359	stage V sporulation protein S
EBI04_RS05050	COG2137	regulation of response to DNA damage stimulus
EBI04_RS05070	COG2766	serine protein kinase
EBI04_RS05080	COG2719	SpoVR family
EBI04_RS05085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EBI04_RS05105	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EBI04_RS05120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EBI04_RS05125	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EBI04_RS05130	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EBI04_RS05135	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EBI04_RS05195	COG2181	nitrate reductase activity
EBI04_RS05210	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EBI04_RS05215	COG2010	Cytochrome c
EBI04_RS05225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EBI04_RS05235	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EBI04_RS05260	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EBI04_RS05275	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EBI04_RS05315	COG3256	nitric oxide reductase
EBI04_RS05320	COG2010	Cytochrome c
EBI04_RS05325	COG2832	Protein of unknown function (DUF454)
EBI04_RS05355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EBI04_RS05360	COG3191	aminopeptidase activity
EBI04_RS05370	COG1063	alcohol dehydrogenase
EBI04_RS05375	COG0714	Associated with various cellular activities
EBI04_RS05390	COG2304	oxidoreductase activity
EBI04_RS05415	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EBI04_RS05420	COG2884	Cell division ATP-binding protein ftsE
EBI04_RS05425	COG0793	Belongs to the peptidase S41A family
EBI04_RS05430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EBI04_RS05430	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EBI04_RS05435	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EBI04_RS05440	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EBI04_RS05450	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EBI04_RS05460	COG0159	tryptophan synthase activity
EBI04_RS05465	COG0133	tryptophan synthase activity
EBI04_RS05470	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
EBI04_RS05480	COG1744	ABC transporter substrate-binding protein PnrA-like
EBI04_RS05485	COG3845	ABC transporter
EBI04_RS05510	COG0745	RESPONSE REGULATOR receiver
EBI04_RS05515	COG0077	Prephenate dehydratase
EBI04_RS05515	COG1605	Chorismate mutase
EBI04_RS05520	COG0517	IMP dehydrogenase activity
EBI04_RS05535	COG1674	ftsk spoiiie
EBI04_RS05540	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EBI04_RS05545	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EBI04_RS05550	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EBI04_RS05555	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EBI04_RS05555	COG4651	solute:proton antiporter activity
EBI04_RS05560	COG0217	transcriptional regulatory protein
EBI04_RS05565	COG0653	protein targeting
EBI04_RS05570	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EBI04_RS05590	COG1960	acyl-CoA dehydrogenase activity
EBI04_RS05600	COG0312	modulator of DNA gyrase
EBI04_RS05605	COG0312	modulator of DNA gyrase
EBI04_RS05620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EBI04_RS05625	COG0730	response to heat
EBI04_RS05655	COG0167	dihydroorotate dehydrogenase activity
EBI04_RS05665	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EBI04_RS05680	COG0746	molybdenum cofactor guanylyltransferase activity
EBI04_RS05685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EBI04_RS05685	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EBI04_RS05695	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EBI04_RS05715	COG0538	isocitrate dehydrogenase activity
EBI04_RS05720	COG0557	exoribonuclease II activity
EBI04_RS05730	COG0585	pseudouridine synthase activity
EBI04_RS05755	COG2050	protein possibly involved in aromatic compounds catabolism
EBI04_RS05765	COG0322	excinuclease ABC activity
EBI04_RS05770	COG0018	arginyl-trna synthetase
EBI04_RS05780	COG1428	Deoxynucleoside kinase
EBI04_RS05785	COG1428	Deoxynucleoside kinase
EBI04_RS05790	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EBI04_RS05795	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EBI04_RS05805	COG0107	imidazoleglycerol-phosphate synthase activity
EBI04_RS05810	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EBI04_RS05810	COG0140	phosphoribosyl-ATP diphosphatase activity
EBI04_RS05815	COG1494	fructose-1,6-bisphosphatase
EBI04_RS05840	COG0395	ABC-type sugar transport system, permease component
EBI04_RS05845	COG1175	transmembrane transport
EBI04_RS05865	COG0084	hydrolase, TatD family'
EBI04_RS05870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EBI04_RS05885	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EBI04_RS05900	COG2009	succinate dehydrogenase
EBI04_RS05910	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EBI04_RS05940	COG0318	PFAM AMP-dependent synthetase and ligase
EBI04_RS05945	COG1104	cysteine desulfurase activity
EBI04_RS05950	COG1959	2 iron, 2 sulfur cluster binding
EBI04_RS05955	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EBI04_RS05960	COG1121	(ABC) transporter
EBI04_RS05965	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EBI04_RS05970	COG2255	four-way junction helicase activity
EBI04_RS05990	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EBI04_RS06000	COG1085	galactose-1-phosphate uridylyltransferase
EBI04_RS06005	COG3345	alpha-galactosidase
EBI04_RS06015	COG3250	beta-galactosidase activity
EBI04_RS06030	COG2211	Major facilitator Superfamily
EBI04_RS06045	COG0193	aminoacyl-tRNA hydrolase activity
EBI04_RS06050	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EBI04_RS06055	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EBI04_RS06060	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EBI04_RS06065	COG1854	S-ribosylhomocysteine lyase activity
EBI04_RS06070	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EBI04_RS06070	COG0519	Catalyzes the synthesis of GMP from XMP
EBI04_RS06080	COG4274	PFAM GYD family protein
EBI04_RS06085	COG0346	lactoylglutathione lyase activity
EBI04_RS06095	COG0328	RNA-DNA hybrid ribonuclease activity
EBI04_RS06100	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EBI04_RS06135	COG0590	tRNA wobble adenosine to inosine editing
EBI04_RS06135	COG0037	tRNA processing
EBI04_RS06160	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
EBI04_RS06165	COG0366	Alpha amylase catalytic
EBI04_RS06170	COG2226	methyltransferase
EBI04_RS06180	COG0693	protein deglycase activity
EBI04_RS06190	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EBI04_RS06200	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EBI04_RS06205	COG0460	homoserine dehydrogenase
EBI04_RS06215	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EBI04_RS06255	COG0037	tRNA processing
EBI04_RS06260	COG2104	thiamine diphosphate biosynthetic process
EBI04_RS06265	COG0123	including yeast histone deacetylase and acetoin utilization protein
EBI04_RS06270	COG0517	IMP dehydrogenase activity
EBI04_RS06280	COG0444	Belongs to the ABC transporter superfamily
EBI04_RS06285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EBI04_RS06305	COG0747	negative chemotaxis
EBI04_RS06315	COG0604	alcohol dehydrogenase
EBI04_RS06320	COG0492	ferredoxin-NADP+ reductase activity
EBI04_RS06350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EBI04_RS06355	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EBI04_RS06360	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EBI04_RS06380	COG2070	2-Nitropropane dioxygenase
EBI04_RS06425	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EBI04_RS06430	COG0572	uridine kinase
EBI04_RS06435	COG0464	growth
EBI04_RS06445	COG1850	ribulose-bisphosphate carboxylase activity
EBI04_RS06455	COG0583	DNA-binding transcription factor activity
EBI04_RS06490	COG2045	Belongs to the ComB family
EBI04_RS06495	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EBI04_RS06610	COG2442	InterPro IPR007367
EBI04_RS06680	COG1737	Transcriptional regulator
EBI04_RS06695	COG0395	ABC-type sugar transport system, permease component
EBI04_RS06700	COG1653	transport
EBI04_RS06710	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EBI04_RS06760	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EBI04_RS06765	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EBI04_RS06790	COG0683	leucine binding
EBI04_RS06800	COG0411	ABC transporter
EBI04_RS06830	COG1942	4-Oxalocrotonate Tautomerase
EBI04_RS06875	COG1129	ABC transporter
EBI04_RS06885	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
EBI04_RS06905	COG0513	Belongs to the DEAD box helicase family
EBI04_RS06910	COG0303	'Molybdopterin
EBI04_RS06930	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
EBI04_RS06935	COG0442	prolyl-tRNA aminoacylation
EBI04_RS06945	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
EBI04_RS06950	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EBI04_RS06955	COG1028	Short-chain dehydrogenase reductase Sdr
EBI04_RS06970	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EBI04_RS06975	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EBI04_RS06995	COG1482	cell wall glycoprotein biosynthetic process
EBI04_RS07005	COG1515	deoxyribonuclease V activity
EBI04_RS07020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EBI04_RS07025	COG0443	Heat shock 70 kDa protein
EBI04_RS07030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EBI04_RS07035	COG0484	heat shock protein binding
EBI04_RS07040	COG0789	Transcriptional regulator
EBI04_RS07045	COG0542	response to heat
EBI04_RS07085	COG0490	domain, Protein
EBI04_RS07090	COG0475	glutathione-regulated potassium exporter activity
EBI04_RS07105	COG3620	sequence-specific DNA binding
EBI04_RS07105	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EBI04_RS07105	COG0617	tRNA 3'-terminal CCA addition
EBI04_RS07110	COG0475	glutathione-regulated potassium exporter activity
EBI04_RS07160	COG0067	glutamate synthase
EBI04_RS07160	COG0069	glutamate synthase activity
EBI04_RS07160	COG0070	glutamate synthase
EBI04_RS07165	COG0247	lactate metabolic process
EBI04_RS07170	COG1139	Iron-sulfur cluster binding protein
EBI04_RS07180	COG0681	Belongs to the peptidase S26 family
EBI04_RS07185	COG1752	Esterase of the alpha-beta hydrolase superfamily
EBI04_RS07190	COG2815	serine threonine protein kinase
EBI04_RS07190	COG0515	serine threonine protein kinase
EBI04_RS07200	COG0860	N-Acetylmuramoyl-L-alanine amidase
EBI04_RS07210	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EBI04_RS07230	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EBI04_RS07230	COG2199	diguanylate cyclase activity
EBI04_RS07240	COG0473	3-isopropylmalate dehydrogenase activity
EBI04_RS07265	COG1450	Type ii and iii secretion system protein
EBI04_RS07270	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EBI04_RS07275	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EBI04_RS07280	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EBI04_RS07290	COG0736	holo-[acyl-carrier-protein] synthase activity
EBI04_RS07305	COG1160	GTP binding
EBI04_RS07320	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EBI04_RS07325	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EBI04_RS07325	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EBI04_RS07330	COG0083	homoserine kinase activity
EBI04_RS07345	COG0268	Binds directly to 16S ribosomal RNA
EBI04_RS07355	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EBI04_RS07360	COG0723	plastoquinol--plastocyanin reductase activity
EBI04_RS07370	COG4235	cytochrome complex assembly
EBI04_RS07370	COG3088	subunit of a heme lyase
EBI04_RS07375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EBI04_RS07380	COG1138	Cytochrome C-type biogenesis protein
EBI04_RS07385	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EBI04_RS07390	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EBI04_RS07400	COG4133	protoheme IX ABC transporter activity
EBI04_RS07405	COG0785	Cytochrome C biogenesis protein
EBI04_RS07415	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EBI04_RS07420	COG0446	pyridine nucleotide-disulphide oxidoreductase
EBI04_RS07435	COG3258	Cytochrome c
EBI04_RS07440	COG2010	Cytochrome c
EBI04_RS07445	COG0737	Belongs to the 5'-nucleotidase family
EBI04_RS07450	COG2010	Cytochrome c
EBI04_RS07455	COG3258	Cytochrome c
EBI04_RS07475	COG2010	Cytochrome c
EBI04_RS07480	COG3842	ATPase activity
EBI04_RS07500	COG0504	CTP synthase activity
EBI04_RS07505	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EBI04_RS07510	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EBI04_RS07535	COG2205	protein histidine kinase activity
EBI04_RS07545	COG0515	serine threonine protein kinase
EBI04_RS07545	COG2815	serine threonine protein kinase
EBI04_RS07550	COG0631	protein serine/threonine phosphatase activity
EBI04_RS07565	COG0113	porphobilinogen synthase activity
EBI04_RS07570	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EBI04_RS07575	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EBI04_RS07600	COG1506	peptidase
EBI04_RS07600	COG4946	Tricorn protease homolog
EBI04_RS07600	COG0823	Involved in the tonB-independent uptake of proteins
EBI04_RS07605	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EBI04_RS07610	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EBI04_RS07630	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EBI04_RS07635	COG1011	Hydrolase
EBI04_RS07645	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EBI04_RS07660	COG0537	adenosine 5'-monophosphoramidase activity
EBI04_RS07665	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EBI04_RS07680	COG0135	phosphoribosylanthranilate isomerase activity
EBI04_RS07685	COG0483	inositol monophosphate 1-phosphatase activity
EBI04_RS07705	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
EBI04_RS07760	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EBI04_RS07765	COG0714	Associated with various cellular activities
EBI04_RS07770	COG0574	Belongs to the PEP-utilizing enzyme family
EBI04_RS07770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EBI04_RS07775	COG1272	protein, Hemolysin III
EBI04_RS07785	COG3850	Histidine kinase
EBI04_RS07785	COG5002	protein histidine kinase activity
EBI04_RS07820	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EBI04_RS07835	COG1011	Hydrolase
EBI04_RS07850	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EBI04_RS07855	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EBI04_RS07865	COG0047	phosphoribosylformylglycinamidine synthase activity
EBI04_RS07880	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EBI04_RS07890	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EBI04_RS07895	COG0497	DNA recombination
EBI04_RS07905	COG2095	MarC family integral membrane protein
EBI04_RS07910	COG1438	arginine binding
EBI04_RS07915	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EBI04_RS07925	COG0194	GDP metabolic process
EBI04_RS07950	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
EBI04_RS07960	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
EBI04_RS07995	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EBI04_RS08000	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EBI04_RS08005	COG0142	geranyltranstransferase activity
EBI04_RS08015	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EBI04_RS08045	COG0203	ribosomal protein L17
EBI04_RS08055	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EBI04_RS08060	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EBI04_RS08065	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EBI04_RS08075	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EBI04_RS08085	COG0563	adenylate kinase activity
EBI04_RS08090	COG0201	protein transport
EBI04_RS08150	COG0255	Belongs to the universal ribosomal protein uL29 family
EBI04_RS08155	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EBI04_RS08160	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EBI04_RS08170	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EBI04_RS08175	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EBI04_RS08180	COG0089	rRNA binding
EBI04_RS08185	COG0088	Forms part of the polypeptide exit tunnel
EBI04_RS08195	COG0051	transcription antitermination factor activity, RNA binding
EBI04_RS08200	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EBI04_RS08210	COG0049	tRNA binding
EBI04_RS08255	COG1461	Dihydroxyacetone kinase
EBI04_RS08270	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EBI04_RS08275	COG1024	Enoyl-CoA hydratase
EBI04_RS08280	COG1187	pseudouridine synthase activity
EBI04_RS08285	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EBI04_RS08295	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EBI04_RS08305	COG0512	Glutamine amidotransferase of anthranilate synthase
EBI04_RS08315	COG1012	belongs to the aldehyde dehydrogenase family
EBI04_RS08320	COG0506	proline dehydrogenase activity
EBI04_RS08345	COG0156	8-amino-7-oxononanoate synthase activity
EBI04_RS08360	COG0187	DNA topoisomerase II activity
EBI04_RS08365	COG1643	Atp-dependent helicase
EBI04_RS08375	COG1063	alcohol dehydrogenase
EBI04_RS08430	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EBI04_RS08430	COG1605	Chorismate mutase
EBI04_RS08435	COG0805	protein transport
EBI04_RS08440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EBI04_RS08445	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EBI04_RS08450	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EBI04_RS08460	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EBI04_RS08465	COG0792	nuclease activity
EBI04_RS08475	COG0492	ferredoxin-NADP+ reductase activity
EBI04_RS08480	COG1028	Short-chain dehydrogenase reductase Sdr
EBI04_RS08485	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EBI04_RS08500	COG1187	pseudouridine synthase activity
EBI04_RS08505	COG2720	vancomycin resistance protein
EBI04_RS08515	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EBI04_RS08520	COG0427	acetyl-CoA hydrolase
EBI04_RS08525	COG0686	Belongs to the AlaDH PNT family
EBI04_RS08540	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EBI04_RS08545	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EBI04_RS08550	COG0071	Belongs to the small heat shock protein (HSP20) family
EBI04_RS08560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EBI04_RS08570	COG1764	response to oxidative stress
EBI04_RS08575	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EBI04_RS08590	COG3842	ATPase activity
EBI04_RS08595	COG0101	tRNA pseudouridine synthase activity
EBI04_RS08600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EBI04_RS08605	COG0601	transmembrane transport
EBI04_RS08610	COG0747	negative chemotaxis
EBI04_RS08615	COG0316	Belongs to the HesB IscA family
EBI04_RS08620	COG0006	proline dipeptidase activity
EBI04_RS08625	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EBI04_RS08640	COG1166	arginine decarboxylase activity
EBI04_RS08650	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EBI04_RS08655	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EBI04_RS08665	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EBI04_RS08690	COG0366	Alpha amylase catalytic
EBI04_RS08700	COG1193	negative regulation of DNA recombination
EBI04_RS08715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EBI04_RS08720	COG2226	methyltransferase
EBI04_RS08725	COG4603	Belongs to the binding-protein-dependent transport system permease family
EBI04_RS08730	COG1079	Belongs to the binding-protein-dependent transport system permease family
EBI04_RS08740	COG1774	PSP1 C-terminal conserved region
EBI04_RS08745	COG0470	DNA polymerase III
EBI04_RS08780	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EBI04_RS08815	COG0723	plastoquinol--plastocyanin reductase activity
EBI04_RS08820	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EBI04_RS08825	COG0539	negative regulation of cytoplasmic translation
EBI04_RS08835	COG0442	prolyl-tRNA aminoacylation
EBI04_RS08855	COG1115	amino acid carrier protein
EBI04_RS08875	COG1489	DNA binding
EBI04_RS08905	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EBI04_RS08910	COG1355	regulation of microtubule-based process
EBI04_RS08925	COG1011	Hydrolase
EBI04_RS08940	COG0589	response to stress
EBI04_RS08945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EBI04_RS08950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EBI04_RS09005	COG0302	gtp cyclohydrolase
EBI04_RS09025	COG1217	gtp-binding protein TYPA
EBI04_RS09035	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EBI04_RS09040	COG0395	ABC-type sugar transport system, permease component
EBI04_RS09045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EBI04_RS09055	COG1131	(ABC) transporter
EBI04_RS09075	COG0556	nucleotide-excision repair
EBI04_RS09080	COG0497	DNA recombination
EBI04_RS09085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EBI04_RS09130	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EBI04_RS09145	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EBI04_RS09150	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EBI04_RS09180	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EBI04_RS09185	COG0346	lactoylglutathione lyase activity
EBI04_RS09195	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EBI04_RS09205	COG0628	permease
EBI04_RS09215	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EBI04_RS09220	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EBI04_RS09225	COG0436	Aminotransferase
EBI04_RS09230	COG1597	lipid kinase activity
EBI04_RS09245	COG0123	including yeast histone deacetylase and acetoin utilization protein
EBI04_RS09250	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EBI04_RS09260	COG0004	ammonium transporteR
EBI04_RS09265	COG0347	Belongs to the P(II) protein family
EBI04_RS09270	COG1420	regulation of RNA biosynthetic process
EBI04_RS09275	COG0314	molybdopterin synthase activity
EBI04_RS09285	COG4636	protein conserved in cyanobacteria
EBI04_RS09290	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EBI04_RS09295	COG1960	acyl-CoA dehydrogenase activity
EBI04_RS09305	COG0495	leucyl-tRNA aminoacylation
EBI04_RS09320	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EBI04_RS09325	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EBI04_RS09345	COG2096	Adenosyltransferase
EBI04_RS09355	COG4555	ABC transporter
EBI04_RS09360	COG1668	transmembrane transport
EBI04_RS09390	COG1660	Displays ATPase and GTPase activities
EBI04_RS09395	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EBI04_RS09440	COG0205	6-phosphofructokinase activity
EBI04_RS09445	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EBI04_RS09455	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EBI04_RS09475	COG0658	competence protein
EBI04_RS09475	COG2333	competence protein COMEC
EBI04_RS09480	COG1475	DNA binding
EBI04_RS09485	COG1192	Involved in chromosome partitioning
EBI04_RS09490	COG0357	Ribosomal RNA small subunit methyltransferase G
EBI04_RS09495	COG0445	tRNA wobble uridine modification
EBI04_RS09500	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EBI04_RS09505	COG0592	DNA-directed DNA polymerase activity
EBI04_RS09510	COG0148	phosphopyruvate hydratase activity
EBI04_RS09515	COG0469	pyruvate kinase activity
EBI04_RS09530	COG0631	protein serine/threonine phosphatase activity
EBI04_RS09535	COG0105	UTP biosynthetic process
EBI04_RS09550	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EBI04_RS09565	COG0842	Transport permease protein
EBI04_RS09570	COG1131	(ABC) transporter
EBI04_RS09580	COG1842	Phage shock protein A
EBI04_RS09590	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EBI04_RS09605	COG0535	radical SAM domain protein
EBI04_RS09610	COG2010	Cytochrome c
EBI04_RS09625	COG0315	cyclic pyranopterin monophosphate synthase activity
EBI04_RS09650	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EBI04_RS09660	COG1278	Cold shock
EBI04_RS09665	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EBI04_RS09685	COG2860	membrane
EBI04_RS09690	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EBI04_RS09710	COG1547	Domain of unknown function (DUF309)
EBI04_RS09725	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EBI04_RS09735	COG2414	aldehyde ferredoxin oxidoreductase
EBI04_RS09745	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EBI04_RS09750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EBI04_RS09755	COG1120	ATPase activity
EBI04_RS09760	COG2226	methyltransferase
EBI04_RS09800	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EBI04_RS09855	COG3956	TIGRFAM MazG family protein
EBI04_RS09865	COG0693	protein deglycase activity
EBI04_RS09870	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EBI04_RS09880	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EBI04_RS09885	COG1937	Protein conserved in bacteria
EBI04_RS09895	COG0674	pyruvate-flavodoxin oxidoreductase activity
EBI04_RS09895	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EBI04_RS09900	COG1013	pyruvate-flavodoxin oxidoreductase activity
EBI04_RS09925	COG0459	protein refolding
EBI04_RS09930	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EBI04_RS09940	COG0714	Associated with various cellular activities
EBI04_RS09960	COG0166	Belongs to the GPI family
EBI04_RS09965	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EBI04_RS09970	COG1612	heme a metabolic process
EBI04_RS09970	COG0109	protoheme IX farnesyltransferase activity
EBI04_RS09975	COG1565	acr, cog1565
EBI04_RS09975	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EBI04_RS10010	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EBI04_RS10015	COG2814	Major facilitator Superfamily
EBI04_RS10020	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EBI04_RS10025	COG0581	inorganic phosphate transmembrane transporter activity
EBI04_RS10030	COG0573	inorganic phosphate transmembrane transporter activity
EBI04_RS10040	COG0482	sulfurtransferase activity
EBI04_RS10050	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EBI04_RS10055	COG0735	belongs to the Fur family
EBI04_RS10070	COG0583	DNA-binding transcription factor activity
EBI04_RS10080	COG0508	dehydrogenase complex catalyzes the overall conversion of
EBI04_RS10095	COG0285	dihydrofolate synthase activity
EBI04_RS10100	COG0436	Aminotransferase
EBI04_RS10115	COG0395	ABC-type sugar transport system, permease component
EBI04_RS10120	COG1175	transmembrane transport
EBI04_RS10125	COG2182	Extracellular solute-binding protein
EBI04_RS10145	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EBI04_RS10155	COG0301	tRNA thio-modification
EBI04_RS10175	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EBI04_RS10185	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EBI04_RS10190	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EBI04_RS10200	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EBI04_RS10215	COG1653	transport
EBI04_RS10235	COG0033	Phosphoglucomutase
EBI04_RS10250	COG2814	Major facilitator Superfamily
EBI04_RS10260	COG0516	GMP reductase activity
EBI04_RS10260	COG0517	IMP dehydrogenase activity
EBI04_RS10265	COG1950	PFAM Membrane protein of
EBI04_RS10300	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EBI04_RS10310	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EBI04_RS10315	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
EBI04_RS10330	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EBI04_RS10335	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EBI04_RS10340	COG1993	acr, cog1993
EBI04_RS10345	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EBI04_RS10355	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EBI04_RS10365	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EBI04_RS10370	COG1335	isochorismatase
EBI04_RS10380	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EBI04_RS10410	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EBI04_RS10415	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EBI04_RS10420	COG0250	Participates in transcription elongation, termination and antitermination
EBI04_RS10430	COG0081	regulation of translation
EBI04_RS10435	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EBI04_RS10440	COG0222	ribosome binding
EBI04_RS10445	COG0163	prenyltransferase activity
EBI04_RS10455	COG0640	Transcriptional regulator
EBI04_RS10460	COG2226	methyltransferase
EBI04_RS10470	COG1960	acyl-CoA dehydrogenase activity
EBI04_RS10475	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EBI04_RS10480	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EBI04_RS10495	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EBI04_RS10500	COG0066	3-isopropylmalate dehydratase activity
EBI04_RS10515	COG0189	ligase activity
EBI04_RS10535	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EBI04_RS10540	COG1543	Belongs to the glycosyl hydrolase 57 family
EBI04_RS10545	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EBI04_RS10545	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EBI04_RS10550	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EBI04_RS10565	COG0445	tRNA wobble uridine modification
EBI04_RS10585	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EBI04_RS10590	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EBI04_RS10595	COG0477	Major facilitator Superfamily
EBI04_RS10610	COG1694	Mazg nucleotide pyrophosphohydrolase
EBI04_RS10615	COG1803	Methylglyoxal synthase
EBI04_RS10625	COG2271	Major facilitator Superfamily
EBI04_RS10630	COG0697	spore germination
EBI04_RS10645	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EBI04_RS10670	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EBI04_RS10675	COG0359	binds to the 23S rRNA
EBI04_RS10685	COG0300	oxidoreductase activity
EBI04_RS10695	COG0321	lipoyl(octanoyl) transferase activity
EBI04_RS10700	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EBI04_RS10725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EBI04_RS10740	COG1598	PFAM Uncharacterised protein family UPF0150
EBI04_RS10745	COG0022	dehydrogenase e1 component
EBI04_RS10750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EBI04_RS10755	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EBI04_RS10780	COG2226	methyltransferase
EBI04_RS10785	COG0432	Pfam Uncharacterised protein family UPF0047
EBI04_RS10790	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EBI04_RS10800	COG0668	transmembrane transport
EBI04_RS10805	COG3253	May function as heme-dependent peroxidase
EBI04_RS10835	COG2205	protein histidine kinase activity
EBI04_RS10840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EBI04_RS10865	COG0632	four-way junction helicase activity
EBI04_RS10870	COG1024	Enoyl-CoA hydratase
EBI04_RS10880	COG0508	dehydrogenase complex catalyzes the overall conversion of
EBI04_RS10890	COG1404	Belongs to the peptidase S8 family
EBI04_RS10900	COG0137	argininosuccinate synthase activity
EBI04_RS10905	COG0165	Argininosuccinate lyase
EBI04_RS10910	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EBI04_RS10910	COG0165	Argininosuccinate lyase
EBI04_RS10925	COG0505	Belongs to the CarA family
EBI04_RS10980	COG2244	polysaccharide biosynthetic process
EBI04_RS10990	COG1215	transferase activity, transferring glycosyl groups
EBI04_RS11045	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EBI04_RS11050	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EBI04_RS11055	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EBI04_RS11060	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EBI04_RS11085	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EBI04_RS11165	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EBI04_RS11170	COG0825	malonyl-CoA metabolic process
EBI04_RS11205	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EBI04_RS11215	COG1278	Cold shock
EBI04_RS11220	COG0484	heat shock protein binding
EBI04_RS11225	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EBI04_RS11230	COG1968	undecaprenyl-diphosphatase activity
EBI04_RS11235	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EBI04_RS11240	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EBI04_RS11255	COG1309	transcriptional regulator
EBI04_RS11265	COG2389	metal-binding protein
EBI04_RS11275	COG0802	atpase or kinase
EBI04_RS11290	COG0437	4 iron, 4 sulfur cluster binding
EBI04_RS11315	COG1252	NADH dehydrogenase
EBI04_RS11325	COG3706	GGDEF domain
EBI04_RS11330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EBI04_RS11335	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EBI04_RS11340	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EBI04_RS11345	COG1185	polyribonucleotide nucleotidyltransferase activity
EBI04_RS11355	COG0416	fatty acid biosynthetic process
EBI04_RS11365	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EBI04_RS11380	COG0284	orotidine-5'-phosphate decarboxylase activity
EBI04_RS11395	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EBI04_RS11415	COG0822	iron-sulfur transferase activity
EBI04_RS11420	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EBI04_RS11435	COG1233	COG1233 Phytoene dehydrogenase and related
EBI04_RS11440	COG1309	transcriptional regulator
EBI04_RS11450	COG2814	Major facilitator Superfamily
EBI04_RS11455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EBI04_RS11485	COG2337	Toxic component of a toxin-antitoxin (TA) module
EBI04_RS11495	COG0393	Putative heavy-metal-binding
EBI04_RS11505	COG2132	Multicopper oxidase
EBI04_RS11545	COG2205	protein histidine kinase activity
EBI04_RS11550	COG0745	RESPONSE REGULATOR receiver
EBI04_RS11560	COG2217	Heavy metal translocating P-type atpase
EBI04_RS11580	COG0719	Fe-S assembly protein
EBI04_RS11585	COG0719	Fe-S assembly protein
EBI04_RS11590	COG0396	ATPase activity
EBI04_RS11605	COG0446	pyridine nucleotide-disulphide oxidoreductase
EBI04_RS11610	COG4181	ATPase activity
EBI04_RS11615	COG0577	efflux transmembrane transporter activity
EBI04_RS11615	COG1136	(ABC) transporter
EBI04_RS11625	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EBI04_RS11635	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EBI04_RS11680	COG1058	Belongs to the CinA family
EBI04_RS11680	COG1546	Belongs to the CinA family
EBI04_RS11685	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EBI04_RS11695	COG1418	mRNA catabolic process
EBI04_RS11695	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EBI04_RS11700	COG1077	Cell shape determining protein MreB Mrl
EBI04_RS11705	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EBI04_RS11725	COG0235	Class ii aldolase
EBI04_RS11735	COG2267	carboxylic ester hydrolase activity
EBI04_RS11745	COG1177	transmembrane transport
EBI04_RS11750	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EBI04_RS11760	COG1607	acyl-coa hydrolase
EBI04_RS11765	COG2154	pterin-4-alpha-carbinolamine dehydratase
EBI04_RS11775	COG0277	FAD linked oxidase domain protein
EBI04_RS11790	COG0667	Aldo Keto reductase
EBI04_RS11805	COG0516	GMP reductase activity
EBI04_RS11805	COG0517	IMP dehydrogenase activity
EBI04_RS11815	COG1067	ATP-dependent peptidase activity
EBI04_RS11820	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EBI04_RS11830	COG0745	RESPONSE REGULATOR receiver
EBI04_RS11835	COG2105	PFAM AIG2 family protein
EBI04_RS11845	COG0297	glycogen (starch) synthase activity
EBI04_RS11860	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EBI04_RS11875	COG0142	geranyltranstransferase activity
EBI04_RS11885	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EBI04_RS12145	COG2814	Major facilitator Superfamily
EBI04_RS12170	COG2205	protein histidine kinase activity
EBI04_RS12190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EBI04_RS12200	COG1324	tolerance protein
EBI04_RS12210	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EBI04_RS12215	COG0739	heme binding
EBI04_RS12215	COG1196	nuclear chromosome segregation
EBI04_RS12215	COG0741	lytic transglycosylase activity
EBI04_RS12225	COG2197	response regulator
EBI04_RS12240	COG1132	(ABC) transporter
EBI04_RS12250	COG0285	dihydrofolate synthase activity
EBI04_RS12285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EBI04_RS12290	COG0601	transmembrane transport
EBI04_RS12295	COG0747	negative chemotaxis
EBI04_RS12325	COG0174	glutamine synthetase
EBI04_RS12330	COG0737	Belongs to the 5'-nucleotidase family
EBI04_RS12355	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EBI04_RS12360	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EBI04_RS12365	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EBI04_RS12370	COG0788	formyltetrahydrofolate deformylase activity
EBI04_RS12385	COG2358	TRAP transporter, solute receptor (TAXI family
EBI04_RS12405	COG2814	Major facilitator Superfamily
EBI04_RS12410	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EBI04_RS12415	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EBI04_RS12420	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EBI04_RS12440	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EBI04_RS12470	COG0247	lactate metabolic process
EBI04_RS12475	COG0277	FAD linked oxidase domain protein
EBI04_RS12480	COG0277	FAD linked oxidase domain protein
EBI04_RS12485	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EBI04_RS12490	COG1414	Transcriptional regulator
EBI04_RS12495	COG0789	Transcriptional regulator
EBI04_RS12510	COG2045	Belongs to the ComB family
EBI04_RS12515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EBI04_RS12520	COG1136	(ABC) transporter
EBI04_RS12525	COG0813	purine-nucleoside phosphorylase activity
EBI04_RS12530	COG1024	Enoyl-CoA hydratase
EBI04_RS12555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EBI04_RS12570	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EBI04_RS12600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EBI04_RS12615	COG2890	protein-(glutamine-N5) methyltransferase activity
EBI04_RS12620	COG1837	Belongs to the UPF0109 family
EBI04_RS12625	COG0706	membrane insertase activity
EBI04_RS12630	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EBI04_RS12650	COG1022	Amp-dependent synthetase and ligase
EBI04_RS12675	COG0564	pseudouridine synthase activity
EBI04_RS12690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EBI04_RS12695	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EBI04_RS12700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EBI04_RS12705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EBI04_RS12715	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EBI04_RS12720	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EBI04_RS12725	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EBI04_RS12745	COG1007	ATP synthesis coupled electron transport
EBI04_RS12750	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EBI04_RS12755	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EBI04_RS12760	COG0713	ATP synthesis coupled electron transport
EBI04_RS12765	COG0839	Belongs to the complex I subunit 6 family
EBI04_RS12770	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EBI04_RS12775	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EBI04_RS12780	COG1034	ATP synthesis coupled electron transport
EBI04_RS12785	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EBI04_RS12790	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
EBI04_RS12795	COG0649	NAD binding
EBI04_RS12800	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EBI04_RS12805	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EBI04_RS12810	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EBI04_RS12815	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EBI04_RS12825	COG4712	double-strand break repair protein
EBI04_RS12865	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EBI04_RS12870	COG0131	Imidazoleglycerol-phosphate dehydratase
EBI04_RS12875	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EBI04_RS12880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EBI04_RS12885	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
EBI04_RS12910	COG0861	Integral membrane protein TerC family
EBI04_RS12915	COG2151	metal-sulfur cluster biosynthetic enzyme
EBI04_RS12920	COG1714	RDD family
EBI04_RS12925	COG0616	signal peptide processing
EBI04_RS12930	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EBI04_RS12935	COG0372	Belongs to the citrate synthase family
EBI04_RS12940	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EBI04_RS12950	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EBI04_RS12955	COG0758	DNA mediated transformation
EBI04_RS12955	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EBI04_RS12960	COG3546	catalase activity
EBI04_RS12995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EBI04_RS13000	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EBI04_RS13005	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EBI04_RS13015	COG0717	Belongs to the dCTP deaminase family
EBI04_RS13030	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
EBI04_RS13035	COG1028	Short-chain dehydrogenase reductase Sdr
EBI04_RS13040	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EBI04_RS13060	COG0251	oxidation-reduction process
EBI04_RS13075	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine