locus-tag	class	description
LDO09_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LDO09_RS00010	COG0592	DNA-directed DNA polymerase activity
LDO09_RS00015	COG0148	phosphopyruvate hydratase activity
LDO09_RS00020	COG0469	pyruvate kinase activity
LDO09_RS00030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LDO09_RS00035	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LDO09_RS00045	COG1842	Phage shock protein A
LDO09_RS00075	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LDO09_RS00080	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LDO09_RS00090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LDO09_RS00095	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
LDO09_RS00100	COG1496	oxidoreductase activity
LDO09_RS00105	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LDO09_RS00110	COG1278	Cold shock
LDO09_RS00120	COG1653	transport
LDO09_RS00135	COG0033	Phosphoglucomutase
LDO09_RS00160	COG0517	IMP dehydrogenase activity
LDO09_RS00160	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LDO09_RS00165	COG1950	PFAM Membrane protein of
LDO09_RS00170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LDO09_RS00175	COG1047	Peptidyl-prolyl cis-trans
LDO09_RS00180	COG0181	hydroxymethylbilane synthase activity
LDO09_RS00190	COG0285	dihydrofolate synthase activity
LDO09_RS00195	COG0436	Aminotransferase
LDO09_RS00200	COG0521	Mo-molybdopterin cofactor biosynthetic process
LDO09_RS00225	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LDO09_RS00230	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LDO09_RS00235	COG1993	acr, cog1993
LDO09_RS00240	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LDO09_RS00250	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LDO09_RS00260	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
LDO09_RS00265	COG1335	isochorismatase
LDO09_RS00270	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LDO09_RS00285	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LDO09_RS00290	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
LDO09_RS00310	COG1660	Displays ATPase and GTPase activities
LDO09_RS00315	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LDO09_RS00380	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LDO09_RS00380	COG1845	cytochrome c oxidase, subunit III
LDO09_RS00385	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LDO09_RS00385	COG2010	Cytochrome c
LDO09_RS00390	COG0109	protoheme IX farnesyltransferase activity
LDO09_RS00390	COG1612	heme a metabolic process
LDO09_RS00405	COG0343	queuine tRNA-ribosyltransferase activity
LDO09_RS00410	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LDO09_RS00415	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LDO09_RS00470	COG1940	carbohydrate kinase activity
LDO09_RS00480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LDO09_RS00485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LDO09_RS00490	COG0589	response to stress
LDO09_RS00495	COG1611	Belongs to the LOG family
LDO09_RS00505	COG1011	Hydrolase
LDO09_RS00510	COG0632	four-way junction helicase activity
LDO09_RS00515	COG1024	Enoyl-CoA hydratase
LDO09_RS00525	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDO09_RS00540	COG1404	Belongs to the peptidase S8 family
LDO09_RS00550	COG0137	argininosuccinate synthase activity
LDO09_RS00555	COG0165	Argininosuccinate lyase
LDO09_RS00565	COG0505	Belongs to the CarA family
LDO09_RS00570	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LDO09_RS00580	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LDO09_RS00585	COG0166	Belongs to the GPI family
LDO09_RS00600	COG0714	Associated with various cellular activities
LDO09_RS00615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LDO09_RS00620	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LDO09_RS00625	COG0459	protein refolding
LDO09_RS00630	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LDO09_RS00635	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LDO09_RS00645	COG0778	Nitroreductase
LDO09_RS00650	COG1388	LysM domain
LDO09_RS00650	COG0791	NLP P60 protein
LDO09_RS00660	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LDO09_RS00670	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LDO09_RS00675	COG0581	inorganic phosphate transmembrane transporter activity
LDO09_RS00680	COG0573	inorganic phosphate transmembrane transporter activity
LDO09_RS00690	COG0482	sulfurtransferase activity
LDO09_RS00700	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LDO09_RS00705	COG0735	belongs to the Fur family
LDO09_RS00720	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LDO09_RS00745	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LDO09_RS00750	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LDO09_RS00755	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LDO09_RS00760	COG0250	Participates in transcription elongation, termination and antitermination
LDO09_RS00770	COG0081	regulation of translation
LDO09_RS00785	COG0629	single-stranded DNA binding
LDO09_RS00790	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LDO09_RS00795	COG0359	binds to the 23S rRNA
LDO09_RS00815	COG0300	oxidoreductase activity
LDO09_RS00820	COG0321	lipoyl(octanoyl) transferase activity
LDO09_RS00825	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LDO09_RS00850	COG1476	TRANSCRIPTIONal
LDO09_RS00870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LDO09_RS00885	COG1598	PFAM Uncharacterised protein family UPF0150
LDO09_RS00890	COG0022	dehydrogenase e1 component
LDO09_RS00895	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LDO09_RS00900	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LDO09_RS00925	COG2226	methyltransferase
LDO09_RS00930	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LDO09_RS00940	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LDO09_RS00945	COG1187	pseudouridine synthase activity
LDO09_RS00955	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LDO09_RS00960	COG0686	Belongs to the AlaDH PNT family
LDO09_RS00970	COG1461	Dihydroxyacetone kinase
LDO09_RS00985	COG4591	ABC-type transport system involved in lipoprotein release permease component
LDO09_RS00990	COG0222	ribosome binding
LDO09_RS00995	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LDO09_RS01005	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LDO09_RS01020	COG0697	spore germination
LDO09_RS01040	COG3177	Filamentation induced by cAMP protein fic
LDO09_RS01050	COG0243	molybdopterin cofactor binding
LDO09_RS01060	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LDO09_RS01070	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LDO09_RS01085	COG0477	Major facilitator Superfamily
LDO09_RS01100	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LDO09_RS01110	COG0105	UTP biosynthetic process
LDO09_RS01115	COG0631	protein serine/threonine phosphatase activity
LDO09_RS01120	COG0583	DNA-binding transcription factor activity
LDO09_RS01130	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDO09_RS01160	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LDO09_RS01170	COG1278	Cold shock
LDO09_RS01175	COG0484	heat shock protein binding
LDO09_RS01180	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LDO09_RS01185	COG1968	undecaprenyl-diphosphatase activity
LDO09_RS01190	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LDO09_RS01195	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LDO09_RS01210	COG1309	transcriptional regulator
LDO09_RS01215	COG4242	Belongs to the peptidase S51 family
LDO09_RS01230	COG0802	atpase or kinase
LDO09_RS01240	COG0539	negative regulation of cytoplasmic translation
LDO09_RS01245	COG0495	leucyl-tRNA aminoacylation
LDO09_RS01265	COG1902	pentaerythritol trinitrate reductase activity
LDO09_RS01290	COG2414	aldehyde ferredoxin oxidoreductase
LDO09_RS01300	COG2165	general secretion pathway protein
LDO09_RS01310	COG2165	general secretion pathway protein
LDO09_RS01340	COG1459	type II secretion system
LDO09_RS01350	COG1187	pseudouridine synthase activity
LDO09_RS01360	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LDO09_RS01365	COG0745	RESPONSE REGULATOR receiver
LDO09_RS01370	COG4191	Histidine kinase
LDO09_RS01375	COG0704	Plays a role in the regulation of phosphate uptake
LDO09_RS01390	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LDO09_RS01400	COG0515	serine threonine protein kinase
LDO09_RS01400	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LDO09_RS01430	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LDO09_RS01435	COG1028	Short-chain dehydrogenase reductase Sdr
LDO09_RS01450	COG0717	Belongs to the dCTP deaminase family
LDO09_RS01455	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
LDO09_RS01460	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LDO09_RS01465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LDO09_RS01485	COG0583	DNA-binding transcription factor activity
LDO09_RS01490	COG3546	catalase activity
LDO09_RS01495	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LDO09_RS01495	COG0758	DNA mediated transformation
LDO09_RS01500	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LDO09_RS01515	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LDO09_RS01525	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
LDO09_RS01535	COG0442	prolyl-tRNA aminoacylation
LDO09_RS01540	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LDO09_RS01560	COG0303	'Molybdopterin
LDO09_RS01565	COG0513	Belongs to the DEAD box helicase family
LDO09_RS01575	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LDO09_RS01585	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LDO09_RS01605	COG2070	2-Nitropropane dioxygenase
LDO09_RS01620	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LDO09_RS01630	COG0018	arginyl-trna synthetase
LDO09_RS01635	COG1007	ATP synthesis coupled electron transport
LDO09_RS01640	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LDO09_RS01645	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LDO09_RS01650	COG0713	ATP synthesis coupled electron transport
LDO09_RS01655	COG0839	Belongs to the complex I subunit 6 family
LDO09_RS01660	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LDO09_RS01665	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LDO09_RS01670	COG1034	ATP synthesis coupled electron transport
LDO09_RS01675	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LDO09_RS01680	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
LDO09_RS01685	COG0649	NAD binding
LDO09_RS01690	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LDO09_RS01695	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LDO09_RS01700	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LDO09_RS01705	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LDO09_RS01715	COG4712	double-strand break repair protein
LDO09_RS01755	COG0135	phosphoribosylanthranilate isomerase activity
LDO09_RS01765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LDO09_RS01775	COG2720	vancomycin resistance protein
LDO09_RS01780	COG1126	abc transporter atp-binding protein
LDO09_RS01810	COG0277	FAD linked oxidase domain protein
LDO09_RS01830	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LDO09_RS01835	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LDO09_RS01850	COG0314	molybdopterin synthase activity
LDO09_RS01855	COG1420	regulation of RNA biosynthetic process
LDO09_RS01860	COG0347	Belongs to the P(II) protein family
LDO09_RS01865	COG0004	ammonium transporteR
LDO09_RS01875	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LDO09_RS01885	COG0123	including yeast histone deacetylase and acetoin utilization protein
LDO09_RS01900	COG1597	lipid kinase activity
LDO09_RS01905	COG0436	Aminotransferase
LDO09_RS01915	COG0569	domain protein
LDO09_RS01915	COG0475	glutathione-regulated potassium exporter activity
LDO09_RS01925	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LDO09_RS01935	COG0277	FAD linked oxidase domain protein
LDO09_RS01960	COG0667	Aldo Keto reductase
LDO09_RS01990	COG1067	ATP-dependent peptidase activity
LDO09_RS01995	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LDO09_RS02005	COG0745	RESPONSE REGULATOR receiver
LDO09_RS02010	COG2105	PFAM AIG2 family protein
LDO09_RS02015	COG0297	glycogen (starch) synthase activity
LDO09_RS02025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LDO09_RS02030	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LDO09_RS02045	COG0142	geranyltranstransferase activity
LDO09_RS02055	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LDO09_RS02075	COG1028	Short-chain dehydrogenase reductase Sdr
LDO09_RS02080	COG0492	ferredoxin-NADP+ reductase activity
LDO09_RS02090	COG0792	nuclease activity
LDO09_RS02095	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LDO09_RS02110	COG1175	transmembrane transport
LDO09_RS02115	COG0395	ABC-type sugar transport system, permease component
LDO09_RS02145	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LDO09_RS02150	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LDO09_RS02155	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LDO09_RS02160	COG0805	protein transport
LDO09_RS02165	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LDO09_RS02165	COG1605	Chorismate mutase
LDO09_RS02225	COG1063	alcohol dehydrogenase
LDO09_RS02255	COG2255	four-way junction helicase activity
LDO09_RS02260	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LDO09_RS02265	COG0564	pseudouridine synthase activity
LDO09_RS02280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LDO09_RS02285	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LDO09_RS02290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LDO09_RS02295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LDO09_RS02305	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LDO09_RS02310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LDO09_RS02315	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LDO09_RS02350	COG0778	Nitroreductase
LDO09_RS02370	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LDO09_RS02375	COG0131	Imidazoleglycerol-phosphate dehydratase
LDO09_RS02380	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LDO09_RS02385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LDO09_RS02390	COG0517	IMP dehydrogenase activity
LDO09_RS02390	COG0516	GMP reductase activity
LDO09_RS02405	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LDO09_RS02410	COG1914	H( )-stimulated, divalent metal cation uptake system
LDO09_RS02425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LDO09_RS02450	COG0706	membrane insertase activity
LDO09_RS02455	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LDO09_RS02460	COG0594	ribonuclease P activity
LDO09_RS02465	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LDO09_RS02475	COG1022	Amp-dependent synthetase and ligase
LDO09_RS02500	COG1121	(ABC) transporter
LDO09_RS02505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LDO09_RS02510	COG1959	2 iron, 2 sulfur cluster binding
LDO09_RS02515	COG1104	cysteine desulfurase activity
LDO09_RS02520	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LDO09_RS02525	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LDO09_RS02540	COG1028	Short-chain dehydrogenase reductase Sdr
LDO09_RS02565	COG0492	ferredoxin-NADP+ reductase activity
LDO09_RS02570	COG0604	alcohol dehydrogenase
LDO09_RS02570	COG3321	synthase
LDO09_RS02570	COG1028	Short-chain dehydrogenase reductase Sdr
LDO09_RS02575	COG0747	negative chemotaxis
LDO09_RS02580	COG0601	transmembrane transport
LDO09_RS02585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDO09_RS02600	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LDO09_RS02600	COG0617	tRNA 3'-terminal CCA addition
LDO09_RS02600	COG0517	IMP dehydrogenase activity
LDO09_RS02605	COG0123	including yeast histone deacetylase and acetoin utilization protein
LDO09_RS02610	COG2104	thiamine diphosphate biosynthetic process
LDO09_RS02615	COG0037	tRNA processing
LDO09_RS02630	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
LDO09_RS02650	COG4176	ABC-type proline glycine betaine transport system permease component
LDO09_RS02655	COG4175	Glycine betaine
LDO09_RS02655	COG3448	diguanylate cyclase activity
LDO09_RS02660	COG0366	Alpha amylase catalytic
LDO09_RS02665	COG2226	methyltransferase
LDO09_RS02670	COG2226	methyltransferase
LDO09_RS02680	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LDO09_RS02690	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LDO09_RS02695	COG0460	homoserine dehydrogenase
LDO09_RS02705	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LDO09_RS02750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LDO09_RS02770	COG0247	lactate metabolic process
LDO09_RS02775	COG0277	FAD linked oxidase domain protein
LDO09_RS02780	COG0277	FAD linked oxidase domain protein
LDO09_RS02785	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LDO09_RS02790	COG1414	Transcriptional regulator
LDO09_RS02795	COG0789	Transcriptional regulator
LDO09_RS02805	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LDO09_RS02810	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
LDO09_RS02845	COG0861	Integral membrane protein TerC family
LDO09_RS02850	COG2151	metal-sulfur cluster biosynthetic enzyme
LDO09_RS02855	COG0281	malic enzyme
LDO09_RS02870	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LDO09_RS02875	COG0509	glycine decarboxylation via glycine cleavage system
LDO09_RS02880	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LDO09_RS02885	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LDO09_RS02890	COG0196	riboflavin kinase activity
LDO09_RS02895	COG0494	nUDIX hydrolase
LDO09_RS02915	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LDO09_RS02920	COG2813	Specifically methylates the guanine in position
LDO09_RS02925	COG0527	aspartate kinase activity
LDO09_RS02955	COG4956	integral membrane protein (PIN domain superfamily)
LDO09_RS02960	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LDO09_RS02965	COG0542	response to heat
LDO09_RS02970	COG0423	glycine-tRNA ligase activity
LDO09_RS02980	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LDO09_RS03000	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LDO09_RS03000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LDO09_RS03010	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LDO09_RS03020	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LDO09_RS03030	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LDO09_RS03035	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LDO09_RS03040	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LDO09_RS03045	COG0114	fumarate hydratase activity
LDO09_RS03050	COG0183	Belongs to the thiolase family
LDO09_RS03065	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LDO09_RS03070	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LDO09_RS03085	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LDO09_RS03090	COG1254	Belongs to the acylphosphatase family
LDO09_RS03100	COG1063	alcohol dehydrogenase
LDO09_RS03110	COG2133	pyrroloquinoline quinone binding
LDO09_RS03120	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LDO09_RS03125	COG0154	amidase activity
LDO09_RS03150	COG0572	uridine kinase
LDO09_RS03155	COG3842	ATPase activity
LDO09_RS03170	COG4475	Protein of unknown function (DUF436)
LDO09_RS03190	COG1595	DNA-templated transcription, initiation
LDO09_RS03250	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LDO09_RS03255	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LDO09_RS03260	COG0803	Belongs to the bacterial solute-binding protein 9 family
LDO09_RS03275	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LDO09_RS03280	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LDO09_RS03285	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LDO09_RS03300	COG1028	Short-chain dehydrogenase reductase Sdr
LDO09_RS03305	COG0318	PFAM AMP-dependent synthetase and ligase
LDO09_RS03310	COG2030	dehydratase
LDO09_RS03310	COG1012	belongs to the aldehyde dehydrogenase family
LDO09_RS03315	COG1960	acyl-CoA dehydrogenase activity
LDO09_RS03330	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LDO09_RS03335	COG1293	RNA-binding protein homologous to eukaryotic snRNP
LDO09_RS03340	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
LDO09_RS03350	COG3870	Protein conserved in bacteria
LDO09_RS03355	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LDO09_RS03375	COG0544	peptidyl-prolyl cis-trans isomerase activity
LDO09_RS03380	COG0740	serine-type endopeptidase activity
LDO09_RS03385	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LDO09_RS03390	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LDO09_RS03395	COG1410	methionine synthase
LDO09_RS03395	COG0646	methionine synthase
LDO09_RS03400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LDO09_RS03430	COG1692	metallophosphoesterase
LDO09_RS03435	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LDO09_RS03480	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LDO09_RS03510	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LDO09_RS03520	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LDO09_RS03525	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LDO09_RS03590	COG0438	transferase activity, transferring glycosyl groups
LDO09_RS03610	COG0438	transferase activity, transferring glycosyl groups
LDO09_RS03615	COG1215	transferase activity, transferring glycosyl groups
LDO09_RS03630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LDO09_RS03650	COG0489	protein tyrosine kinase activity
LDO09_RS03660	COG2264	protein methyltransferase activity
LDO09_RS03665	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LDO09_RS03695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LDO09_RS03695	COG0574	Belongs to the PEP-utilizing enzyme family
LDO09_RS03705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LDO09_RS03710	COG2046	Belongs to the sulfate adenylyltransferase family
LDO09_RS03715	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LDO09_RS03715	COG1648	precorrin-2 dehydrogenase activity
LDO09_RS03720	COG0730	response to heat
LDO09_RS03725	COG0175	sulfate reduction
LDO09_RS03730	COG1648	precorrin-2 dehydrogenase activity
LDO09_RS03730	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LDO09_RS03735	COG1587	Uroporphyrinogen-III synthase
LDO09_RS03740	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LDO09_RS03760	COG0352	thiamine-phosphate diphosphorylase activity
LDO09_RS03765	COG2104	thiamine diphosphate biosynthetic process
LDO09_RS03770	COG2022	thiamine diphosphate biosynthetic process
LDO09_RS03775	COG2022	thiamine diphosphate biosynthetic process
LDO09_RS03775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LDO09_RS03780	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LDO09_RS03785	COG0477	Major facilitator Superfamily
LDO09_RS03790	COG0351	phosphomethylpyrimidine kinase
LDO09_RS03820	COG1175	transmembrane transport
LDO09_RS03830	COG1940	carbohydrate kinase activity
LDO09_RS03835	COG0183	Belongs to the thiolase family
LDO09_RS03850	COG1028	Short-chain dehydrogenase reductase Sdr
LDO09_RS03880	COG1064	alcohol dehydrogenase
LDO09_RS03885	COG1012	belongs to the aldehyde dehydrogenase family
LDO09_RS03890	COG3835	regulator
LDO09_RS03910	COG0559	Belongs to the binding-protein-dependent transport system permease family
LDO09_RS03920	COG2030	dehydratase
LDO09_RS03930	COG0596	Alpha beta hydrolase
LDO09_RS03935	COG0318	PFAM AMP-dependent synthetase and ligase
LDO09_RS03950	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LDO09_RS03950	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LDO09_RS03960	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LDO09_RS03970	COG0195	Participates in both transcription termination and antitermination
LDO09_RS03975	COG0779	Required for maturation of 30S ribosomal subunits
LDO09_RS03985	COG0739	heme binding
LDO09_RS03990	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
LDO09_RS03995	COG0640	Transcriptional regulator
LDO09_RS04000	COG2217	Heavy metal translocating P-type atpase
LDO09_RS04010	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
LDO09_RS04015	COG0017	Asparaginyl-tRNA synthetase
LDO09_RS04020	COG0561	phosphatase activity
LDO09_RS04025	COG0384	phenazine biosynthesis protein PhzF
LDO09_RS04035	COG0124	histidyl-tRNA synthetase
LDO09_RS04045	COG3842	ATPase activity
LDO09_RS04065	COG1573	uracil-dna glycosylase
LDO09_RS04085	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LDO09_RS04090	COG0519	Catalyzes the synthesis of GMP from XMP
LDO09_RS04090	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LDO09_RS04100	COG1316	TRANSCRIPTIONal
LDO09_RS04110	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LDO09_RS04155	COG0295	cytidine deaminase activity
LDO09_RS04175	COG1760	l-serine dehydratase
LDO09_RS04185	COG0481	GTPase activity
LDO09_RS04195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LDO09_RS04200	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LDO09_RS04210	COG1028	Short-chain dehydrogenase reductase Sdr
LDO09_RS04235	COG0405	Gamma-glutamyltransferase
LDO09_RS04245	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LDO09_RS04250	COG2873	o-acetylhomoserine
LDO09_RS04265	COG1063	alcohol dehydrogenase
LDO09_RS04275	COG3191	aminopeptidase activity
LDO09_RS04280	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LDO09_RS04290	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LDO09_RS04295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LDO09_RS04300	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LDO09_RS04305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LDO09_RS04320	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LDO09_RS04335	COG0167	dihydroorotate dehydrogenase activity
LDO09_RS04375	COG0730	response to heat
LDO09_RS04380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LDO09_RS04400	COG1960	acyl-CoA dehydrogenase activity
LDO09_RS04405	COG0456	acetyltransferase
LDO09_RS04415	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LDO09_RS04420	COG0009	L-threonylcarbamoyladenylate synthase
LDO09_RS04425	COG1459	type II secretion system
LDO09_RS04440	COG0277	FAD linked oxidase domain protein
LDO09_RS04450	COG0287	Prephenate dehydrogenase
LDO09_RS04455	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LDO09_RS04460	COG2514	catechol 2,3-dioxygenase activity
LDO09_RS04465	COG2353	YceI-like domain
LDO09_RS04470	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
LDO09_RS04475	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LDO09_RS04495	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LDO09_RS04500	COG0179	Fumarylacetoacetate (FAA) hydrolase
LDO09_RS04510	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LDO09_RS04515	COG0151	Belongs to the GarS family
LDO09_RS04520	COG2176	DNA-directed DNA polymerase activity
LDO09_RS04520	COG5002	protein histidine kinase activity
LDO09_RS04550	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LDO09_RS04560	COG0217	transcriptional regulatory protein
LDO09_RS04565	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LDO09_RS04565	COG4651	solute:proton antiporter activity
LDO09_RS04570	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LDO09_RS04575	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LDO09_RS04580	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LDO09_RS04585	COG1674	ftsk spoiiie
LDO09_RS04600	COG0517	IMP dehydrogenase activity
LDO09_RS04620	COG3620	sequence-specific DNA binding
LDO09_RS04620	COG0617	tRNA 3'-terminal CCA addition
LDO09_RS04620	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LDO09_RS04630	COG1994	Peptidase M50
LDO09_RS04635	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LDO09_RS04645	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LDO09_RS04660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LDO09_RS04665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LDO09_RS04670	COG2719	SpoVR family
LDO09_RS04675	COG2718	Belongs to the UPF0229 family
LDO09_RS04680	COG2766	serine protein kinase
LDO09_RS04710	COG2137	regulation of response to DNA damage stimulus
LDO09_RS04720	COG2359	stage V sporulation protein S
LDO09_RS04725	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LDO09_RS04730	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LDO09_RS04740	COG0463	Glycosyl transferase, family 2
LDO09_RS04745	COG0750	zinc metalloprotease
LDO09_RS04750	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LDO09_RS04755	COG0575	Belongs to the CDS family
LDO09_RS04760	COG0233	cytoplasmic translational termination
LDO09_RS04765	COG0528	UMP kinase activity
LDO09_RS04770	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LDO09_RS04775	COG0052	Belongs to the universal ribosomal protein uS2 family
LDO09_RS04785	COG0582	viral genome integration into host DNA
LDO09_RS04830	COG1598	PFAM Uncharacterised protein family UPF0150
LDO09_RS04865	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LDO09_RS04870	COG0494	nUDIX hydrolase
LDO09_RS04890	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LDO09_RS04900	COG0402	S-adenosylhomocysteine deaminase activity
LDO09_RS04910	COG4948	Mandelate Racemase Muconate Lactonizing
LDO09_RS04915	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LDO09_RS04920	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LDO09_RS04925	COG1811	Na channel or pump
LDO09_RS04930	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LDO09_RS04930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LDO09_RS04945	COG1215	transferase activity, transferring glycosyl groups
LDO09_RS04955	COG1215	transferase activity, transferring glycosyl groups
LDO09_RS04965	COG0438	transferase activity, transferring glycosyl groups
LDO09_RS04970	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
LDO09_RS04990	COG1250	3-hydroxyacyl-CoA dehydrogenase
LDO09_RS04990	COG1024	Enoyl-CoA hydratase
LDO09_RS04995	COG0183	Belongs to the thiolase family
LDO09_RS05000	COG1960	acyl-CoA dehydrogenase activity
LDO09_RS05005	COG0215	cysteine-tRNA ligase activity
LDO09_RS05010	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LDO09_RS05045	COG1196	nuclear chromosome segregation
LDO09_RS05060	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LDO09_RS05065	COG3153	acetyltransferase
LDO09_RS05065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LDO09_RS05070	COG1268	BioY protein
LDO09_RS05080	COG0126	phosphoglycerate kinase activity
LDO09_RS05085	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LDO09_RS05090	COG0824	Thioesterase
LDO09_RS05100	COG0557	exoribonuclease II activity
LDO09_RS05105	COG1355	regulation of microtubule-based process
LDO09_RS05110	COG0617	tRNA 3'-terminal CCA addition
LDO09_RS05110	COG1353	crispr-associated protein
LDO09_RS05115	COG0237	dephospho-CoA kinase activity
LDO09_RS05130	COG0742	ribosomal rna small subunit methyltransferase
LDO09_RS05135	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LDO09_RS05140	COG0138	bifunctional purine biosynthesis protein purh
LDO09_RS05145	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LDO09_RS05155	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LDO09_RS05215	COG0149	triose-phosphate isomerase activity
LDO09_RS05220	COG3239	Fatty acid desaturase
LDO09_RS05230	COG1490	D-aminoacyl-tRNA deacylase activity
LDO09_RS05235	COG1307	EDD domain protein, DegV family
LDO09_RS05240	COG1307	EDD domain protein, DegV family
LDO09_RS05245	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LDO09_RS05250	COG1510	regulation of RNA biosynthetic process
LDO09_RS05270	COG1136	(ABC) transporter
LDO09_RS05285	COG3769	mannosylglycerate metabolic process
LDO09_RS05295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LDO09_RS05305	COG1012	belongs to the aldehyde dehydrogenase family
LDO09_RS05310	COG2368	4-hydroxyphenylacetate
LDO09_RS05315	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LDO09_RS05345	COG2050	protein possibly involved in aromatic compounds catabolism
LDO09_RS05350	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
LDO09_RS05360	COG1012	belongs to the aldehyde dehydrogenase family
LDO09_RS05360	COG2030	dehydratase
LDO09_RS05380	COG3396	Phenylacetate-CoA oxygenase
LDO09_RS05390	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LDO09_RS05400	COG0395	ABC-type sugar transport system, permease component
LDO09_RS05420	COG1980	fructose-bisphosphate aldolase activity
LDO09_RS05425	COG1733	regulation of RNA biosynthetic process
LDO09_RS05430	COG2193	ferroxidase activity
LDO09_RS05435	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LDO09_RS05440	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LDO09_RS05450	COG1331	Highly conserved protein containing a thioredoxin domain
LDO09_RS05455	COG0183	Belongs to the thiolase family
LDO09_RS05460	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LDO09_RS05465	COG0477	Major facilitator Superfamily
LDO09_RS05470	COG1846	Transcriptional regulator
LDO09_RS05515	COG1012	belongs to the aldehyde dehydrogenase family
LDO09_RS05525	COG0248	Ppx GppA phosphatase
LDO09_RS05530	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LDO09_RS05535	COG0210	DNA helicase
LDO09_RS05550	COG1309	transcriptional regulator
LDO09_RS05555	COG1131	(ABC) transporter
LDO09_RS05575	COG0842	Transport permease protein
LDO09_RS05605	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LDO09_RS05630	COG0582	viral genome integration into host DNA
LDO09_RS05645	COG2897	thiosulfate sulfurtransferase activity
LDO09_RS05650	COG1760	l-serine dehydratase
LDO09_RS05660	COG0335	large ribosomal subunit rRNA binding
LDO09_RS05665	COG0336	Belongs to the RNA methyltransferase TrmD family
LDO09_RS05670	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LDO09_RS05675	COG1837	Belongs to the UPF0109 family
LDO09_RS05680	COG0228	four-way junction DNA binding
LDO09_RS05695	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LDO09_RS05700	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LDO09_RS05700	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LDO09_RS05705	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LDO09_RS05715	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LDO09_RS05725	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LDO09_RS05730	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LDO09_RS05735	COG1702	phosphate starvation-inducible protein PhoH
LDO09_RS05745	COG4864	UPF0365 protein
LDO09_RS05755	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LDO09_RS05765	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LDO09_RS05765	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LDO09_RS05770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LDO09_RS05780	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LDO09_RS05785	COG1397	ADP-ribosylglycohydrolase
LDO09_RS05790	COG2239	Acts as a magnesium transporter
LDO09_RS05795	COG2304	oxidoreductase activity
LDO09_RS05800	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LDO09_RS05800	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LDO09_RS05810	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LDO09_RS05810	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LDO09_RS05815	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LDO09_RS05820	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LDO09_RS05825	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LDO09_RS05830	COG0006	proline dipeptidase activity
LDO09_RS05840	COG0739	heme binding
LDO09_RS05850	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
LDO09_RS05855	COG0254	rRNA binding
LDO09_RS05870	COG2001	Belongs to the MraZ family
LDO09_RS05875	COG0275	rRNA processing
LDO09_RS05890	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LDO09_RS05900	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LDO09_RS05905	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LDO09_RS05910	COG0772	Belongs to the SEDS family
LDO09_RS05915	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LDO09_RS05920	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LDO09_RS05925	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LDO09_RS05945	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LDO09_RS05960	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LDO09_RS05970	COG0159	tryptophan synthase activity
LDO09_RS05975	COG0133	tryptophan synthase activity
LDO09_RS05980	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
LDO09_RS05985	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LDO09_RS05990	COG1744	ABC transporter substrate-binding protein PnrA-like
LDO09_RS05995	COG3845	ABC transporter
LDO09_RS06045	COG0438	transferase activity, transferring glycosyl groups
LDO09_RS06050	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LDO09_RS06060	COG0039	L-malate dehydrogenase activity
LDO09_RS06065	COG2819	hydrolase of the alpha beta superfamily
LDO09_RS06070	COG0861	Integral membrane protein TerC family
LDO09_RS06080	COG0247	lactate metabolic process
LDO09_RS06080	COG2181	nitrate reductase activity
LDO09_RS06090	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
LDO09_RS06095	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LDO09_RS06100	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LDO09_RS06110	COG0439	Biotin carboxylase
LDO09_RS06115	COG0511	ligase activity, forming carbon-carbon bonds
LDO09_RS06120	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LDO09_RS06140	COG0010	Belongs to the arginase family
LDO09_RS06155	COG1100	Small GTP-binding protein
LDO09_RS06165	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LDO09_RS06170	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LDO09_RS06180	COG2814	Major facilitator Superfamily
LDO09_RS06185	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LDO09_RS06190	COG1185	polyribonucleotide nucleotidyltransferase activity
LDO09_RS06195	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LDO09_RS06200	COG0589	response to stress
LDO09_RS06225	COG0617	tRNA 3'-terminal CCA addition
LDO09_RS06225	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LDO09_RS06225	COG0517	IMP dehydrogenase activity
LDO09_RS06230	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LDO09_RS06235	COG0745	RESPONSE REGULATOR receiver
LDO09_RS06240	COG5002	protein histidine kinase activity
LDO09_RS06245	COG1960	acyl-CoA dehydrogenase activity
LDO09_RS06250	COG2086	electron transfer activity
LDO09_RS06255	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LDO09_RS06265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LDO09_RS06270	COG1573	uracil-dna glycosylase
LDO09_RS06275	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LDO09_RS06275	COG1796	DNA polymerase
LDO09_RS06285	COG2309	aminopeptidase activity
LDO09_RS06295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LDO09_RS06305	COG1011	Hydrolase
LDO09_RS06320	COG2873	o-acetylhomoserine
LDO09_RS06325	COG2358	TRAP transporter, solute receptor (TAXI family
LDO09_RS06335	COG1126	abc transporter atp-binding protein
LDO09_RS06350	COG0134	indole-3-glycerol-phosphate synthase activity
LDO09_RS06355	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LDO09_RS06365	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LDO09_RS06380	COG0765	amino acid transport
LDO09_RS06385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDO09_RS06395	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LDO09_RS06400	COG0569	domain protein
LDO09_RS06405	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LDO09_RS06410	COG1426	Protein conserved in bacteria
LDO09_RS06415	COG2313	pseudouridylate synthase activity
LDO09_RS06425	COG3001	Fructosamine kinase
LDO09_RS06430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LDO09_RS06440	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
LDO09_RS06465	COG0012	GTP binding
LDO09_RS06470	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LDO09_RS06480	COG0424	maF-like protein
LDO09_RS06495	COG0768	penicillin binding
LDO09_RS06505	COG0850	regulation of cytokinetic process
LDO09_RS06510	COG2322	membrane
LDO09_RS06530	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LDO09_RS06535	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LDO09_RS06545	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LDO09_RS06565	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LDO09_RS06575	COG1131	(ABC) transporter
LDO09_RS06590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LDO09_RS06605	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LDO09_RS06610	COG0440	acetolactate synthase activity
LDO09_RS06615	COG0028	Belongs to the TPP enzyme family
LDO09_RS06630	COG4970	Tfp pilus assembly protein FimT
LDO09_RS06635	COG4970	Tfp pilus assembly protein FimT
LDO09_RS06640	COG2165	general secretion pathway protein
LDO09_RS06645	COG4966	pilus assembly protein PilW
LDO09_RS06655	COG2165	general secretion pathway protein
LDO09_RS06665	COG4636	protein conserved in cyanobacteria
LDO09_RS06690	COG0180	Tryptophanyl-tRNA synthetase
LDO09_RS06695	COG0544	peptidyl-prolyl cis-trans isomerase activity
LDO09_RS06700	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LDO09_RS06705	COG0066	3-isopropylmalate dehydratase activity
LDO09_RS06710	COG0473	3-isopropylmalate dehydrogenase activity
LDO09_RS06725	COG0300	oxidoreductase activity
LDO09_RS06730	COG0129	dihydroxy-acid dehydratase activity
LDO09_RS06740	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LDO09_RS06745	COG1177	transmembrane transport
LDO09_RS06750	COG1176	ABC-type spermidine putrescine transport system, permease component I
LDO09_RS06755	COG3842	ATPase activity
LDO09_RS06760	COG0772	Belongs to the SEDS family
LDO09_RS06765	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LDO09_RS06770	COG2894	cell division
LDO09_RS06775	COG1733	regulation of RNA biosynthetic process
LDO09_RS06785	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LDO09_RS06785	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LDO09_RS06795	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LDO09_RS06800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LDO09_RS06805	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LDO09_RS06810	COG0653	protein targeting
LDO09_RS06815	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LDO09_RS06835	COG0393	Putative heavy-metal-binding
LDO09_RS06840	COG1111	helicase
LDO09_RS06840	COG1205	dead DEAH box helicase
LDO09_RS06855	COG0358	DNA primase activity
LDO09_RS06870	COG1250	3-hydroxyacyl-CoA dehydrogenase
LDO09_RS06875	COG0697	spore germination
LDO09_RS06880	COG0612	Peptidase, M16
LDO09_RS06885	COG0612	Peptidase, M16
LDO09_RS06890	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LDO09_RS06905	COG1394	ATPase activity, coupled to movement of substances
LDO09_RS06910	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
LDO09_RS06915	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
LDO09_RS06920	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
LDO09_RS06925	COG1527	subunit (C
LDO09_RS06930	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
LDO09_RS06940	COG1269	ATP hydrolysis coupled proton transport
LDO09_RS06965	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LDO09_RS06975	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LDO09_RS06990	COG0419	ATPase involved in DNA repair
LDO09_RS06995	COG0420	3'-5' exonuclease activity
LDO09_RS07015	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LDO09_RS07020	COG2884	Cell division ATP-binding protein ftsE
LDO09_RS07025	COG0793	Belongs to the peptidase S41A family
LDO09_RS07030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LDO09_RS07030	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LDO09_RS07035	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LDO09_RS07040	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LDO09_RS07050	COG1079	Belongs to the binding-protein-dependent transport system permease family
LDO09_RS07055	COG4603	Belongs to the binding-protein-dependent transport system permease family
LDO09_RS07060	COG1129	ABC transporter
LDO09_RS07065	COG0746	molybdenum cofactor guanylyltransferase activity
LDO09_RS07080	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LDO09_RS07100	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LDO09_RS07105	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LDO09_RS07110	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LDO09_RS07125	COG2358	TRAP transporter, solute receptor (TAXI family
LDO09_RS07135	COG2358	TRAP transporter, solute receptor (TAXI family
LDO09_RS07150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LDO09_RS07155	COG0788	formyltetrahydrofolate deformylase activity
LDO09_RS07160	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LDO09_RS07165	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LDO09_RS07170	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LDO09_RS07190	COG0737	Belongs to the 5'-nucleotidase family
LDO09_RS07195	COG0174	glutamine synthetase
LDO09_RS07205	COG0559	Belongs to the binding-protein-dependent transport system permease family
LDO09_RS07225	COG0747	negative chemotaxis
LDO09_RS07230	COG0601	transmembrane transport
LDO09_RS07235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDO09_RS07245	COG0285	dihydrofolate synthase activity
LDO09_RS07250	COG1132	(ABC) transporter
LDO09_RS07255	COG1132	(ABC) transporter
LDO09_RS07260	COG0372	Belongs to the citrate synthase family
LDO09_RS07265	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LDO09_RS07270	COG1482	cell wall glycoprotein biosynthetic process
LDO09_RS07280	COG1515	deoxyribonuclease V activity
LDO09_RS07290	COG0776	regulation of translation
LDO09_RS07305	COG2197	response regulator
LDO09_RS07310	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LDO09_RS07315	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LDO09_RS07320	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LDO09_RS07325	COG1324	tolerance protein
LDO09_RS07330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LDO09_RS07350	COG2205	protein histidine kinase activity
LDO09_RS07385	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LDO09_RS07390	COG0247	lactate metabolic process
LDO09_RS07395	COG1139	Iron-sulfur cluster binding protein
LDO09_RS07400	COG1556	Lactate utilization protein
LDO09_RS07410	COG1752	Esterase of the alpha-beta hydrolase superfamily
LDO09_RS07415	COG2815	serine threonine protein kinase
LDO09_RS07415	COG0515	serine threonine protein kinase
LDO09_RS07420	COG0860	N-Acetylmuramoyl-L-alanine amidase
LDO09_RS07430	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LDO09_RS07470	COG0473	3-isopropylmalate dehydrogenase activity
LDO09_RS07495	COG1450	Type ii and iii secretion system protein
LDO09_RS07500	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LDO09_RS07505	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LDO09_RS07510	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LDO09_RS07515	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LDO09_RS07515	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
LDO09_RS07520	COG0736	holo-[acyl-carrier-protein] synthase activity
LDO09_RS07535	COG1160	GTP binding
LDO09_RS07540	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LDO09_RS07545	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LDO09_RS07545	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LDO09_RS07550	COG2814	Major facilitator Superfamily
LDO09_RS07555	COG0083	homoserine kinase activity
LDO09_RS07570	COG0268	Binds directly to 16S ribosomal RNA
LDO09_RS07580	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LDO09_RS07590	COG0723	plastoquinol--plastocyanin reductase activity
LDO09_RS07600	COG4235	cytochrome complex assembly
LDO09_RS07600	COG3088	subunit of a heme lyase
LDO09_RS07605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LDO09_RS07610	COG1138	Cytochrome C-type biogenesis protein
LDO09_RS07615	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LDO09_RS07620	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LDO09_RS07625	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LDO09_RS07630	COG4133	protoheme IX ABC transporter activity
LDO09_RS07635	COG0785	Cytochrome C biogenesis protein
LDO09_RS07660	COG3258	Cytochrome c
LDO09_RS07670	COG0446	pyridine nucleotide-disulphide oxidoreductase
LDO09_RS07685	COG3258	Cytochrome c
LDO09_RS07690	COG2010	Cytochrome c
LDO09_RS07695	COG0737	Belongs to the 5'-nucleotidase family
LDO09_RS07700	COG2010	Cytochrome c
LDO09_RS07705	COG3258	Cytochrome c
LDO09_RS07725	COG2010	Cytochrome c
LDO09_RS07730	COG3842	ATPase activity
LDO09_RS07760	COG0318	PFAM AMP-dependent synthetase and ligase
LDO09_RS07765	COG3360	Dodecin
LDO09_RS07780	COG1024	Enoyl-CoA hydratase
LDO09_RS07785	COG0813	purine-nucleoside phosphorylase activity
LDO09_RS07790	COG1136	(ABC) transporter
LDO09_RS07795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LDO09_RS07800	COG2045	Belongs to the ComB family
LDO09_RS07810	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LDO09_RS07820	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
LDO09_RS07830	COG0107	imidazoleglycerol-phosphate synthase activity
LDO09_RS07835	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LDO09_RS07835	COG0140	phosphoribosyl-ATP diphosphatase activity
LDO09_RS07840	COG1494	fructose-1,6-bisphosphatase
LDO09_RS07845	COG0686	Belongs to the AlaDH PNT family
LDO09_RS07850	COG0427	acetyl-CoA hydrolase
LDO09_RS07855	COG0084	hydrolase, TatD family'
LDO09_RS07860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LDO09_RS07870	COG0017	Asparaginyl-tRNA synthetase
LDO09_RS07880	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LDO09_RS07895	COG2009	succinate dehydrogenase
LDO09_RS07900	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LDO09_RS07930	COG0318	PFAM AMP-dependent synthetase and ligase
LDO09_RS07935	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LDO09_RS07940	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LDO09_RS07945	COG0504	CTP synthase activity
LDO09_RS07960	COG0070	glutamate synthase
LDO09_RS07960	COG0069	glutamate synthase activity
LDO09_RS07960	COG0067	glutamate synthase
LDO09_RS08010	COG0840	transmembrane signaling receptor activity
LDO09_RS08015	COG0305	Participates in initiation and elongation during chromosome replication
LDO09_RS08025	COG0475	glutathione-regulated potassium exporter activity
LDO09_RS08030	COG0517	IMP dehydrogenase activity
LDO09_RS08030	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LDO09_RS08030	COG0617	tRNA 3'-terminal CCA addition
LDO09_RS08045	COG0475	glutathione-regulated potassium exporter activity
LDO09_RS08050	COG0490	domain, Protein
LDO09_RS08070	COG3118	belongs to the thioredoxin family
LDO09_RS08125	COG0789	Transcriptional regulator
LDO09_RS08130	COG0484	heat shock protein binding
LDO09_RS08135	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LDO09_RS08140	COG0443	Heat shock 70 kDa protein
LDO09_RS08145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LDO09_RS08150	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LDO09_RS08155	COG0616	signal peptide processing
LDO09_RS08170	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
LDO09_RS08175	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LDO09_RS08180	COG0714	Associated with various cellular activities
LDO09_RS08185	COG0574	Belongs to the PEP-utilizing enzyme family
LDO09_RS08185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LDO09_RS08190	COG1272	protein, Hemolysin III
LDO09_RS08200	COG3850	Histidine kinase
LDO09_RS08200	COG5002	protein histidine kinase activity
LDO09_RS08225	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LDO09_RS08240	COG1011	Hydrolase
LDO09_RS08255	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LDO09_RS08270	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LDO09_RS08280	COG0047	phosphoribosylformylglycinamidine synthase activity
LDO09_RS08290	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LDO09_RS08295	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LDO09_RS08300	COG0116	Belongs to the methyltransferase superfamily
LDO09_RS08315	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LDO09_RS08320	COG0497	DNA recombination
LDO09_RS08330	COG0604	alcohol dehydrogenase
LDO09_RS08350	COG0585	pseudouridine synthase activity
LDO09_RS08375	COG1595	DNA-templated transcription, initiation
LDO09_RS08380	COG0557	exoribonuclease II activity
LDO09_RS08385	COG0538	isocitrate dehydrogenase activity
LDO09_RS08390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LDO09_RS08390	COG2022	thiamine diphosphate biosynthetic process
LDO09_RS08400	COG0590	tRNA wobble adenosine to inosine editing
LDO09_RS08400	COG0037	tRNA processing
LDO09_RS08425	COG2050	protein possibly involved in aromatic compounds catabolism
LDO09_RS08435	COG0322	excinuclease ABC activity
LDO09_RS08440	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LDO09_RS08445	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LDO09_RS08450	COG1854	S-ribosylhomocysteine lyase activity
LDO09_RS08465	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LDO09_RS08465	COG0519	Catalyzes the synthesis of GMP from XMP
LDO09_RS08470	COG4636	protein conserved in cyanobacteria
LDO09_RS08475	COG4274	PFAM GYD family protein
LDO09_RS08480	COG0346	lactoylglutathione lyase activity
LDO09_RS08485	COG0328	RNA-DNA hybrid ribonuclease activity
LDO09_RS08490	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LDO09_RS08495	COG2095	MarC family integral membrane protein
LDO09_RS08500	COG1438	arginine binding
LDO09_RS08505	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LDO09_RS08510	COG1758	RNA polymerase activity
LDO09_RS08515	COG0194	GDP metabolic process
LDO09_RS08525	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LDO09_RS08530	COG2385	sporulation resulting in formation of a cellular spore
LDO09_RS08535	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
LDO09_RS08545	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
LDO09_RS08585	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LDO09_RS08590	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LDO09_RS08595	COG1012	belongs to the aldehyde dehydrogenase family
LDO09_RS08600	COG0506	proline dehydrogenase activity
LDO09_RS08615	COG0156	8-amino-7-oxononanoate synthase activity
LDO09_RS08620	COG0732	type I restriction modification DNA specificity domain
LDO09_RS08620	COG0827	DNA restriction-modification system
LDO09_RS08630	COG0187	DNA topoisomerase II activity
LDO09_RS08635	COG1181	Belongs to the D-alanine--D-alanine ligase family
LDO09_RS08640	COG0193	aminoacyl-tRNA hydrolase activity
LDO09_RS08645	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LDO09_RS08670	COG2815	serine threonine protein kinase
LDO09_RS08670	COG0515	serine threonine protein kinase
LDO09_RS08675	COG0631	protein serine/threonine phosphatase activity
LDO09_RS08685	COG2814	Major facilitator Superfamily
LDO09_RS08690	COG0113	porphobilinogen synthase activity
LDO09_RS08695	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LDO09_RS08700	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LDO09_RS08725	COG0823	Involved in the tonB-independent uptake of proteins
LDO09_RS08725	COG1506	peptidase
LDO09_RS08725	COG4946	Tricorn protease homolog
LDO09_RS08730	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LDO09_RS08735	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LDO09_RS08755	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LDO09_RS08760	COG1011	Hydrolase
LDO09_RS08785	COG0537	adenosine 5'-monophosphoramidase activity
LDO09_RS08790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LDO09_RS08795	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LDO09_RS08800	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LDO09_RS08805	COG0071	Belongs to the small heat shock protein (HSP20) family
LDO09_RS08810	COG2897	thiosulfate sulfurtransferase activity
LDO09_RS08815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LDO09_RS08825	COG1764	response to oxidative stress
LDO09_RS08850	COG3842	ATPase activity
LDO09_RS08855	COG0101	tRNA pseudouridine synthase activity
LDO09_RS08860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDO09_RS08865	COG0601	transmembrane transport
LDO09_RS08900	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LDO09_RS08915	COG1166	arginine decarboxylase activity
LDO09_RS08925	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LDO09_RS08930	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LDO09_RS08935	COG1611	Belongs to the LOG family
LDO09_RS08940	COG1193	negative regulation of DNA recombination
LDO09_RS08945	COG0366	Alpha amylase catalytic
LDO09_RS08980	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LDO09_RS08985	COG0142	geranyltranstransferase activity
LDO09_RS08995	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LDO09_RS09025	COG0203	ribosomal protein L17
LDO09_RS09030	COG0202	RNA polymerase activity
LDO09_RS09035	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LDO09_RS09040	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LDO09_RS09045	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LDO09_RS09055	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LDO09_RS09065	COG0563	adenylate kinase activity
LDO09_RS09070	COG0201	protein transport
LDO09_RS09095	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LDO09_RS09100	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LDO09_RS09105	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LDO09_RS09130	COG0255	Belongs to the universal ribosomal protein uL29 family
LDO09_RS09135	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LDO09_RS09140	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LDO09_RS09150	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LDO09_RS09155	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LDO09_RS09160	COG0089	rRNA binding
LDO09_RS09165	COG0088	Forms part of the polypeptide exit tunnel
LDO09_RS09175	COG0051	transcription antitermination factor activity, RNA binding
LDO09_RS09180	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LDO09_RS09185	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LDO09_RS09190	COG0049	tRNA binding
LDO09_RS09205	COG0442	prolyl-tRNA aminoacylation
LDO09_RS09215	COG1115	amino acid carrier protein
LDO09_RS09235	COG1489	DNA binding
LDO09_RS09260	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LDO09_RS09280	COG0432	Pfam Uncharacterised protein family UPF0047
LDO09_RS09285	COG3253	May function as heme-dependent peroxidase
LDO09_RS09290	COG0668	transmembrane transport
LDO09_RS09300	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LDO09_RS09305	COG2217	Heavy metal translocating P-type atpase
LDO09_RS09325	COG0745	RESPONSE REGULATOR receiver
LDO09_RS09330	COG2205	protein histidine kinase activity
LDO09_RS09350	COG2226	methyltransferase
LDO09_RS09370	COG2132	Multicopper oxidase
LDO09_RS09380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LDO09_RS09385	COG0822	iron-sulfur transferase activity
LDO09_RS09405	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LDO09_RS09415	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LDO09_RS09420	COG0284	orotidine-5'-phosphate decarboxylase activity
LDO09_RS09435	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LDO09_RS09445	COG0416	fatty acid biosynthetic process
LDO09_RS09450	COG3118	belongs to the thioredoxin family
LDO09_RS09455	COG1185	polyribonucleotide nucleotidyltransferase activity
LDO09_RS09460	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LDO09_RS09470	COG0438	transferase activity, transferring glycosyl groups
LDO09_RS09485	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LDO09_RS09490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LDO09_RS09495	COG3706	GGDEF domain
LDO09_RS09530	COG0437	4 iron, 4 sulfur cluster binding
LDO09_RS09545	COG0825	malonyl-CoA metabolic process
LDO09_RS09550	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LDO09_RS09585	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LDO09_RS09610	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LDO09_RS09615	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LDO09_RS09620	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LDO09_RS09625	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LDO09_RS09645	COG4974	Belongs to the 'phage' integrase family
LDO09_RS09725	COG0315	cyclic pyranopterin monophosphate synthase activity
LDO09_RS09730	COG2860	membrane
LDO09_RS09735	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LDO09_RS09750	COG0477	Major facilitator Superfamily
LDO09_RS09755	COG1694	Mazg nucleotide pyrophosphohydrolase
LDO09_RS09760	COG1803	Methylglyoxal synthase
LDO09_RS09770	COG0301	tRNA thio-modification
LDO09_RS09775	COG0154	amidase activity
LDO09_RS09780	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LDO09_RS09800	COG2154	pterin-4-alpha-carbinolamine dehydratase
LDO09_RS09805	COG1607	acyl-coa hydrolase
LDO09_RS09815	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LDO09_RS09820	COG4149	molybdate abc transporter
LDO09_RS09825	COG1840	ABC-type Fe3 transport system, periplasmic component
LDO09_RS09840	COG0235	Class ii aldolase
LDO09_RS09845	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LDO09_RS09850	COG0085	RNA polymerase activity
LDO09_RS09860	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LDO09_RS09865	COG1077	Cell shape determining protein MreB Mrl
LDO09_RS09870	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LDO09_RS09870	COG1418	mRNA catabolic process
LDO09_RS09875	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LDO09_RS09880	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
LDO09_RS09885	COG1058	Belongs to the CinA family
LDO09_RS09885	COG1546	Belongs to the CinA family
LDO09_RS09890	COG0354	folic acid binding
LDO09_RS09905	COG4948	Mandelate Racemase Muconate Lactonizing
LDO09_RS09920	COG1175	transmembrane transport
LDO09_RS09930	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LDO09_RS09940	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LDO09_RS09950	COG0577	efflux transmembrane transporter activity
LDO09_RS09950	COG1136	(ABC) transporter
LDO09_RS09955	COG4181	ATPase activity
LDO09_RS09960	COG0446	pyridine nucleotide-disulphide oxidoreductase
LDO09_RS09975	COG0396	ATPase activity
LDO09_RS09980	COG0719	Fe-S assembly protein
LDO09_RS09985	COG0719	Fe-S assembly protein
LDO09_RS09990	COG2146	nitrite reductase [NAD(P)H] activity
LDO09_RS10000	COG0512	Glutamine amidotransferase of anthranilate synthase
LDO09_RS10005	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LDO09_RS10040	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LDO09_RS10045	COG2226	methyltransferase
LDO09_RS10050	COG4603	Belongs to the binding-protein-dependent transport system permease family
LDO09_RS10055	COG1079	Belongs to the binding-protein-dependent transport system permease family
LDO09_RS10070	COG1774	PSP1 C-terminal conserved region
LDO09_RS10075	COG0470	DNA polymerase III
LDO09_RS10110	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LDO09_RS10115	COG0302	gtp cyclohydrolase
LDO09_RS10140	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LDO09_RS10150	COG0395	ABC-type sugar transport system, permease component
LDO09_RS10165	COG1131	(ABC) transporter
LDO09_RS10185	COG0556	nucleotide-excision repair
LDO09_RS10190	COG0497	DNA recombination
LDO09_RS10195	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LDO09_RS10205	COG0445	tRNA wobble uridine modification
LDO09_RS10225	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LDO09_RS10225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LDO09_RS10230	COG1543	Belongs to the glycosyl hydrolase 57 family
LDO09_RS10235	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LDO09_RS10240	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LDO09_RS10245	COG0189	ligase activity
LDO09_RS10260	COG0066	3-isopropylmalate dehydratase activity
LDO09_RS10265	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LDO09_RS10280	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LDO09_RS10285	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LDO09_RS10290	COG1960	acyl-CoA dehydrogenase activity
LDO09_RS10295	COG0163	prenyltransferase activity
LDO09_RS10345	COG2096	Adenosyltransferase
LDO09_RS10365	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LDO09_RS10370	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LDO09_RS10380	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LDO09_RS10385	COG0723	plastoquinol--plastocyanin reductase activity
LDO09_RS10395	COG2010	Cytochrome c
LDO09_RS10415	COG1653	transport
LDO09_RS10420	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LDO09_RS10425	COG1960	acyl-CoA dehydrogenase activity
LDO09_RS10435	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LDO09_RS10470	COG1131	(ABC) transporter
LDO09_RS10495	COG3956	TIGRFAM MazG family protein
LDO09_RS10505	COG0693	protein deglycase activity
LDO09_RS10510	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LDO09_RS10520	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LDO09_RS10525	COG1937	Protein conserved in bacteria
LDO09_RS10535	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LDO09_RS10535	COG0674	pyruvate-flavodoxin oxidoreductase activity
LDO09_RS10540	COG1013	pyruvate-flavodoxin oxidoreductase activity
LDO09_RS10545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LDO09_RS10565	COG0205	6-phosphofructokinase activity
LDO09_RS10570	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LDO09_RS10580	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LDO09_RS10595	COG0658	competence protein
LDO09_RS10595	COG2333	competence protein COMEC
LDO09_RS10600	COG1475	DNA binding
LDO09_RS10605	COG1192	Involved in chromosome partitioning
LDO09_RS10610	COG0357	Ribosomal RNA small subunit methyltransferase G
LDO09_RS10615	COG0445	tRNA wobble uridine modification
LDO09_RS10625	COG1028	Short-chain dehydrogenase reductase Sdr
LDO09_RS10630	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LDO09_RS10635	COG1785	Belongs to the alkaline phosphatase family
LDO09_RS10640	COG1492	cobalamin metabolic process
LDO09_RS10675	COG0778	Nitroreductase
LDO09_RS10680	COG1648	precorrin-2 dehydrogenase activity
LDO09_RS10680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LDO09_RS10725	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
LDO09_RS10730	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
LDO09_RS10735	COG0588	phosphoglycerate mutase activity
LDO09_RS10750	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
LDO09_RS10760	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
LDO09_RS10765	COG1797	cobyrinic acid a,c-diamide synthase activity
LDO09_RS10870	COG1063	alcohol dehydrogenase
LDO09_RS10885	COG3181	Tripartite tricarboxylate transporter family receptor
LDO09_RS10940	COG2084	Dehydrogenase
LDO09_RS10950	COG1942	4-Oxalocrotonate Tautomerase
LDO09_RS11015	COG3850	Histidine kinase
LDO09_RS11015	COG5002	protein histidine kinase activity
LDO09_RS11020	COG0745	RESPONSE REGULATOR receiver
LDO09_RS11060	COG0863	Belongs to the N(4) N(6)-methyltransferase family
LDO09_RS11165	COG2329	Antibiotic biosynthesis monooxygenase
LDO09_RS11185	COG1914	H( )-stimulated, divalent metal cation uptake system
LDO09_RS11195	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LDO09_RS11220	COG0671	phosphoesterase, PA-phosphatase related
LDO09_RS11250	COG0730	response to heat
LDO09_RS11265	COG0363	glucosamine-6-phosphate deaminase activity
LDO09_RS11270	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LDO09_RS11275	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LDO09_RS11320	COG2010	Cytochrome c
LDO09_RS11325	COG0745	RESPONSE REGULATOR receiver
LDO09_RS11330	COG2205	protein histidine kinase activity
LDO09_RS11365	COG3335	DDE superfamily endonuclease
LDO09_RS11370	COG0513	Belongs to the DEAD box helicase family
LDO09_RS11380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LDO09_RS11385	COG1475	DNA binding
LDO09_RS11400	COG0514	ATP-dependent DNA helicase (RecQ)
LDO09_RS11430	COG1402	creatininase
LDO09_RS11435	COG1802	Transcriptional regulator
LDO09_RS11440	COG1063	alcohol dehydrogenase
LDO09_RS11460	COG2181	nitrate reductase activity
LDO09_RS11470	COG1140	nitrate reductase beta subunit
LDO09_RS11475	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
LDO09_RS11480	COG2010	Cytochrome c
LDO09_RS11490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LDO09_RS11500	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
LDO09_RS11525	COG1252	NADH dehydrogenase
LDO09_RS11530	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LDO09_RS11540	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LDO09_RS11595	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LDO09_RS11615	COG2010	Cytochrome c
LDO09_RS11620	COG0535	radical SAM domain protein
LDO09_RS11635	COG3256	nitric oxide reductase
LDO09_RS11685	COG1192	Involved in chromosome partitioning
LDO09_RS11690	COG1475	DNA binding
LDO09_RS11730	COG3345	alpha-galactosidase
LDO09_RS11735	COG1085	galactose-1-phosphate uridylyltransferase
LDO09_RS11765	COG1304	FMN binding
LDO09_RS11775	COG1487	ribonuclease activity
LDO09_RS11800	COG2124	cytochrome p450
LDO09_RS11810	COG1562	ergosterol biosynthetic process
LDO09_RS11820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LDO09_RS11835	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LDO09_RS11850	COG1175	transmembrane transport
LDO09_RS11865	COG1028	Short-chain dehydrogenase reductase Sdr
LDO09_RS11870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LDO09_RS11880	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LDO09_RS11885	COG0800	Aldolase
LDO09_RS11935	COG4974	Belongs to the 'phage' integrase family
LDO09_RS11960	COG1192	Involved in chromosome partitioning
LDO09_RS12050	COG3335	DDE superfamily endonuclease
LDO09_RS12085	COG3335	DDE superfamily endonuclease
LDO09_RS12110	COG3335	DDE superfamily endonuclease
LDO09_RS12130	COG3335	DDE superfamily endonuclease
LDO09_RS12145	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LDO09_RS12150	COG0642	Histidine kinase