locus-tag	class	description
AA2Tth_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AA2Tth_RS00010	COG0592	DNA-directed DNA polymerase activity
AA2Tth_RS00015	COG0148	phosphopyruvate hydratase activity
AA2Tth_RS00020	COG0469	pyruvate kinase activity
AA2Tth_RS00030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AA2Tth_RS00035	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AA2Tth_RS00045	COG1842	Phage shock protein A
AA2Tth_RS00080	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AA2Tth_RS00085	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AA2Tth_RS00095	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AA2Tth_RS00100	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AA2Tth_RS00105	COG1496	oxidoreductase activity
AA2Tth_RS00110	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AA2Tth_RS00115	COG1278	Cold shock
AA2Tth_RS00120	COG1653	transport
AA2Tth_RS00135	COG0033	Phosphoglucomutase
AA2Tth_RS00160	COG0517	IMP dehydrogenase activity
AA2Tth_RS00160	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AA2Tth_RS00165	COG1950	PFAM Membrane protein of
AA2Tth_RS00170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AA2Tth_RS00175	COG1047	Peptidyl-prolyl cis-trans
AA2Tth_RS00180	COG0181	hydroxymethylbilane synthase activity
AA2Tth_RS00190	COG0285	dihydrofolate synthase activity
AA2Tth_RS00195	COG0436	Aminotransferase
AA2Tth_RS00200	COG0521	Mo-molybdopterin cofactor biosynthetic process
AA2Tth_RS00220	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AA2Tth_RS00225	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AA2Tth_RS00230	COG1993	acr, cog1993
AA2Tth_RS00235	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AA2Tth_RS00245	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AA2Tth_RS00255	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AA2Tth_RS00260	COG1335	isochorismatase
AA2Tth_RS00265	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AA2Tth_RS00280	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AA2Tth_RS00285	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AA2Tth_RS00305	COG1660	Displays ATPase and GTPase activities
AA2Tth_RS00310	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AA2Tth_RS00355	COG3335	DDE superfamily endonuclease
AA2Tth_RS00380	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AA2Tth_RS00380	COG1845	cytochrome c oxidase, subunit III
AA2Tth_RS00385	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AA2Tth_RS00385	COG2010	Cytochrome c
AA2Tth_RS00390	COG1612	heme a metabolic process
AA2Tth_RS00390	COG0109	protoheme IX farnesyltransferase activity
AA2Tth_RS00405	COG0343	queuine tRNA-ribosyltransferase activity
AA2Tth_RS00410	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AA2Tth_RS00415	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AA2Tth_RS00475	COG1940	carbohydrate kinase activity
AA2Tth_RS00485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AA2Tth_RS00490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AA2Tth_RS00495	COG0589	response to stress
AA2Tth_RS00500	COG1611	Belongs to the LOG family
AA2Tth_RS00510	COG1011	Hydrolase
AA2Tth_RS00515	COG0632	four-way junction helicase activity
AA2Tth_RS00520	COG1024	Enoyl-CoA hydratase
AA2Tth_RS00530	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA2Tth_RS00540	COG0137	argininosuccinate synthase activity
AA2Tth_RS00545	COG0165	Argininosuccinate lyase
AA2Tth_RS00565	COG0505	Belongs to the CarA family
AA2Tth_RS00575	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AA2Tth_RS00580	COG0166	Belongs to the GPI family
AA2Tth_RS00590	COG0714	Associated with various cellular activities
AA2Tth_RS00605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AA2Tth_RS00610	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AA2Tth_RS00615	COG0459	protein refolding
AA2Tth_RS00620	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AA2Tth_RS00625	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AA2Tth_RS00635	COG0778	Nitroreductase
AA2Tth_RS00640	COG1388	LysM domain
AA2Tth_RS00640	COG0791	NLP P60 protein
AA2Tth_RS00650	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA2Tth_RS00660	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AA2Tth_RS00665	COG0581	inorganic phosphate transmembrane transporter activity
AA2Tth_RS00670	COG0573	inorganic phosphate transmembrane transporter activity
AA2Tth_RS00680	COG0482	sulfurtransferase activity
AA2Tth_RS00690	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AA2Tth_RS00695	COG0735	belongs to the Fur family
AA2Tth_RS00710	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AA2Tth_RS00735	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AA2Tth_RS00740	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AA2Tth_RS00745	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AA2Tth_RS00750	COG0250	Participates in transcription elongation, termination and antitermination
AA2Tth_RS00775	COG0629	single-stranded DNA binding
AA2Tth_RS00780	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AA2Tth_RS00785	COG0359	binds to the 23S rRNA
AA2Tth_RS00805	COG0300	oxidoreductase activity
AA2Tth_RS00810	COG0321	lipoyl(octanoyl) transferase activity
AA2Tth_RS00815	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AA2Tth_RS00840	COG1476	TRANSCRIPTIONal
AA2Tth_RS00860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AA2Tth_RS00875	COG1598	PFAM Uncharacterised protein family UPF0150
AA2Tth_RS00880	COG0022	dehydrogenase e1 component
AA2Tth_RS00885	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AA2Tth_RS00890	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AA2Tth_RS00915	COG2226	methyltransferase
AA2Tth_RS00920	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AA2Tth_RS00930	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AA2Tth_RS00935	COG1187	pseudouridine synthase activity
AA2Tth_RS00945	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AA2Tth_RS00950	COG0686	Belongs to the AlaDH PNT family
AA2Tth_RS00960	COG1461	Dihydroxyacetone kinase
AA2Tth_RS00975	COG4591	ABC-type transport system involved in lipoprotein release permease component
AA2Tth_RS00980	COG0222	ribosome binding
AA2Tth_RS00985	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AA2Tth_RS00995	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AA2Tth_RS01010	COG0697	spore germination
AA2Tth_RS01025	COG3177	Filamentation induced by cAMP protein fic
AA2Tth_RS01035	COG0243	molybdopterin cofactor binding
AA2Tth_RS01045	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AA2Tth_RS01055	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AA2Tth_RS01070	COG0477	Major facilitator Superfamily
AA2Tth_RS01085	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AA2Tth_RS01095	COG0105	UTP biosynthetic process
AA2Tth_RS01100	COG0631	protein serine/threonine phosphatase activity
AA2Tth_RS01105	COG0583	DNA-binding transcription factor activity
AA2Tth_RS01115	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA2Tth_RS01145	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AA2Tth_RS01155	COG1278	Cold shock
AA2Tth_RS01160	COG0484	heat shock protein binding
AA2Tth_RS01165	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AA2Tth_RS01170	COG1968	undecaprenyl-diphosphatase activity
AA2Tth_RS01175	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AA2Tth_RS01180	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AA2Tth_RS01195	COG1309	transcriptional regulator
AA2Tth_RS01200	COG4242	Belongs to the peptidase S51 family
AA2Tth_RS01215	COG0802	atpase or kinase
AA2Tth_RS01225	COG0539	negative regulation of cytoplasmic translation
AA2Tth_RS01230	COG0495	leucyl-tRNA aminoacylation
AA2Tth_RS01250	COG1902	pentaerythritol trinitrate reductase activity
AA2Tth_RS01275	COG2414	aldehyde ferredoxin oxidoreductase
AA2Tth_RS01285	COG2165	general secretion pathway protein
AA2Tth_RS01295	COG2165	general secretion pathway protein
AA2Tth_RS01325	COG1459	type II secretion system
AA2Tth_RS01335	COG1187	pseudouridine synthase activity
AA2Tth_RS01340	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AA2Tth_RS01345	COG0745	RESPONSE REGULATOR receiver
AA2Tth_RS01350	COG4191	Histidine kinase
AA2Tth_RS01355	COG0704	Plays a role in the regulation of phosphate uptake
AA2Tth_RS01370	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AA2Tth_RS01380	COG0515	serine threonine protein kinase
AA2Tth_RS01380	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AA2Tth_RS01415	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AA2Tth_RS01420	COG1028	Short-chain dehydrogenase reductase Sdr
AA2Tth_RS01435	COG0717	Belongs to the dCTP deaminase family
AA2Tth_RS01440	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AA2Tth_RS01445	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AA2Tth_RS01450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AA2Tth_RS01470	COG0583	DNA-binding transcription factor activity
AA2Tth_RS01475	COG3546	catalase activity
AA2Tth_RS01480	COG0758	DNA mediated transformation
AA2Tth_RS01480	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AA2Tth_RS01485	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AA2Tth_RS01500	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AA2Tth_RS01510	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
AA2Tth_RS01520	COG0442	prolyl-tRNA aminoacylation
AA2Tth_RS01525	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AA2Tth_RS01545	COG0303	'Molybdopterin
AA2Tth_RS01550	COG0513	Belongs to the DEAD box helicase family
AA2Tth_RS01560	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AA2Tth_RS01570	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AA2Tth_RS01590	COG2070	2-Nitropropane dioxygenase
AA2Tth_RS01605	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AA2Tth_RS01615	COG0018	arginyl-trna synthetase
AA2Tth_RS01620	COG1007	ATP synthesis coupled electron transport
AA2Tth_RS01625	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA2Tth_RS01630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AA2Tth_RS01635	COG0713	ATP synthesis coupled electron transport
AA2Tth_RS01640	COG0839	Belongs to the complex I subunit 6 family
AA2Tth_RS01645	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA2Tth_RS01650	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AA2Tth_RS01655	COG1034	ATP synthesis coupled electron transport
AA2Tth_RS01660	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AA2Tth_RS01665	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AA2Tth_RS01670	COG0649	NAD binding
AA2Tth_RS01675	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA2Tth_RS01680	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA2Tth_RS01685	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA2Tth_RS01690	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AA2Tth_RS01700	COG4712	double-strand break repair protein
AA2Tth_RS01740	COG0135	phosphoribosylanthranilate isomerase activity
AA2Tth_RS01750	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AA2Tth_RS01760	COG2720	vancomycin resistance protein
AA2Tth_RS01765	COG1126	abc transporter atp-binding protein
AA2Tth_RS01795	COG0277	FAD linked oxidase domain protein
AA2Tth_RS01810	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AA2Tth_RS01815	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AA2Tth_RS01830	COG0314	molybdopterin synthase activity
AA2Tth_RS01835	COG1420	regulation of RNA biosynthetic process
AA2Tth_RS01840	COG0347	Belongs to the P(II) protein family
AA2Tth_RS01845	COG0004	ammonium transporteR
AA2Tth_RS01855	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AA2Tth_RS01865	COG0123	including yeast histone deacetylase and acetoin utilization protein
AA2Tth_RS01880	COG1597	lipid kinase activity
AA2Tth_RS01890	COG0436	Aminotransferase
AA2Tth_RS01900	COG0569	domain protein
AA2Tth_RS01900	COG0475	glutathione-regulated potassium exporter activity
AA2Tth_RS01910	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AA2Tth_RS01920	COG0277	FAD linked oxidase domain protein
AA2Tth_RS01945	COG0667	Aldo Keto reductase
AA2Tth_RS01965	COG2199	diguanylate cyclase activity
AA2Tth_RS01975	COG1067	ATP-dependent peptidase activity
AA2Tth_RS01980	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AA2Tth_RS01990	COG0745	RESPONSE REGULATOR receiver
AA2Tth_RS01995	COG2105	PFAM AIG2 family protein
AA2Tth_RS02000	COG0297	glycogen (starch) synthase activity
AA2Tth_RS02010	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AA2Tth_RS02015	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AA2Tth_RS02030	COG0142	geranyltranstransferase activity
AA2Tth_RS02040	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AA2Tth_RS02060	COG1028	Short-chain dehydrogenase reductase Sdr
AA2Tth_RS02065	COG0492	ferredoxin-NADP+ reductase activity
AA2Tth_RS02075	COG0792	nuclease activity
AA2Tth_RS02080	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AA2Tth_RS02095	COG1175	transmembrane transport
AA2Tth_RS02100	COG0395	ABC-type sugar transport system, permease component
AA2Tth_RS02130	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AA2Tth_RS02135	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AA2Tth_RS02140	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AA2Tth_RS02145	COG0805	protein transport
AA2Tth_RS02150	COG1605	Chorismate mutase
AA2Tth_RS02150	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AA2Tth_RS02210	COG1063	alcohol dehydrogenase
AA2Tth_RS02240	COG2255	four-way junction helicase activity
AA2Tth_RS02245	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AA2Tth_RS02250	COG0564	pseudouridine synthase activity
AA2Tth_RS02265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA2Tth_RS02270	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AA2Tth_RS02275	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AA2Tth_RS02280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AA2Tth_RS02290	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AA2Tth_RS02295	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AA2Tth_RS02300	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AA2Tth_RS02335	COG0778	Nitroreductase
AA2Tth_RS02350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AA2Tth_RS02355	COG0131	Imidazoleglycerol-phosphate dehydratase
AA2Tth_RS02360	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AA2Tth_RS02365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AA2Tth_RS02370	COG0516	GMP reductase activity
AA2Tth_RS02370	COG0517	IMP dehydrogenase activity
AA2Tth_RS02385	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AA2Tth_RS02390	COG1914	H( )-stimulated, divalent metal cation uptake system
AA2Tth_RS02405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AA2Tth_RS02420	COG2890	protein-(glutamine-N5) methyltransferase activity
AA2Tth_RS02430	COG0706	membrane insertase activity
AA2Tth_RS02435	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AA2Tth_RS02440	COG0594	ribonuclease P activity
AA2Tth_RS02445	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AA2Tth_RS02455	COG1022	Amp-dependent synthetase and ligase
AA2Tth_RS02480	COG1121	(ABC) transporter
AA2Tth_RS02485	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AA2Tth_RS02490	COG1959	2 iron, 2 sulfur cluster binding
AA2Tth_RS02495	COG1104	cysteine desulfurase activity
AA2Tth_RS02500	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AA2Tth_RS02505	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AA2Tth_RS02520	COG1028	Short-chain dehydrogenase reductase Sdr
AA2Tth_RS02545	COG0492	ferredoxin-NADP+ reductase activity
AA2Tth_RS02555	COG3321	synthase
AA2Tth_RS02555	COG1028	Short-chain dehydrogenase reductase Sdr
AA2Tth_RS02555	COG0604	alcohol dehydrogenase
AA2Tth_RS02565	COG0601	transmembrane transport
AA2Tth_RS02570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2Tth_RS02585	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AA2Tth_RS02585	COG0617	tRNA 3'-terminal CCA addition
AA2Tth_RS02585	COG0517	IMP dehydrogenase activity
AA2Tth_RS02590	COG0123	including yeast histone deacetylase and acetoin utilization protein
AA2Tth_RS02595	COG2104	thiamine diphosphate biosynthetic process
AA2Tth_RS02600	COG0037	tRNA processing
AA2Tth_RS02615	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AA2Tth_RS02635	COG4176	ABC-type proline glycine betaine transport system permease component
AA2Tth_RS02640	COG3448	diguanylate cyclase activity
AA2Tth_RS02640	COG4175	Glycine betaine
AA2Tth_RS02645	COG0366	Alpha amylase catalytic
AA2Tth_RS02650	COG2226	methyltransferase
AA2Tth_RS02655	COG2226	methyltransferase
AA2Tth_RS02665	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AA2Tth_RS02675	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AA2Tth_RS02680	COG0460	homoserine dehydrogenase
AA2Tth_RS02690	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AA2Tth_RS02735	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AA2Tth_RS02755	COG0247	lactate metabolic process
AA2Tth_RS02760	COG0277	FAD linked oxidase domain protein
AA2Tth_RS02765	COG0277	FAD linked oxidase domain protein
AA2Tth_RS02770	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AA2Tth_RS02775	COG1414	Transcriptional regulator
AA2Tth_RS02780	COG0789	Transcriptional regulator
AA2Tth_RS02790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AA2Tth_RS02795	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AA2Tth_RS02830	COG0861	Integral membrane protein TerC family
AA2Tth_RS02835	COG2151	metal-sulfur cluster biosynthetic enzyme
AA2Tth_RS02840	COG0281	malic enzyme
AA2Tth_RS02855	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AA2Tth_RS02860	COG0509	glycine decarboxylation via glycine cleavage system
AA2Tth_RS02865	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AA2Tth_RS02870	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AA2Tth_RS02875	COG0196	riboflavin kinase activity
AA2Tth_RS02880	COG0494	nUDIX hydrolase
AA2Tth_RS02900	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AA2Tth_RS02905	COG2813	Specifically methylates the guanine in position
AA2Tth_RS02910	COG0527	aspartate kinase activity
AA2Tth_RS02940	COG4956	integral membrane protein (PIN domain superfamily)
AA2Tth_RS02945	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AA2Tth_RS02950	COG0542	response to heat
AA2Tth_RS02955	COG0423	glycine-tRNA ligase activity
AA2Tth_RS02970	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AA2Tth_RS02990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AA2Tth_RS02990	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AA2Tth_RS03000	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AA2Tth_RS03010	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AA2Tth_RS03020	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AA2Tth_RS03025	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AA2Tth_RS03030	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AA2Tth_RS03035	COG0114	fumarate hydratase activity
AA2Tth_RS03040	COG0183	Belongs to the thiolase family
AA2Tth_RS03055	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AA2Tth_RS03060	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AA2Tth_RS03075	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AA2Tth_RS03080	COG1254	Belongs to the acylphosphatase family
AA2Tth_RS03090	COG1063	alcohol dehydrogenase
AA2Tth_RS03100	COG2133	pyrroloquinoline quinone binding
AA2Tth_RS03110	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AA2Tth_RS03115	COG0154	amidase activity
AA2Tth_RS03140	COG0572	uridine kinase
AA2Tth_RS03145	COG3842	ATPase activity
AA2Tth_RS03160	COG4475	Protein of unknown function (DUF436)
AA2Tth_RS03180	COG1595	DNA-templated transcription, initiation
AA2Tth_RS03245	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AA2Tth_RS03250	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AA2Tth_RS03255	COG0803	Belongs to the bacterial solute-binding protein 9 family
AA2Tth_RS03270	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AA2Tth_RS03275	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AA2Tth_RS03280	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AA2Tth_RS03285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AA2Tth_RS03295	COG1028	Short-chain dehydrogenase reductase Sdr
AA2Tth_RS03300	COG0318	PFAM AMP-dependent synthetase and ligase
AA2Tth_RS03305	COG2030	dehydratase
AA2Tth_RS03305	COG1012	belongs to the aldehyde dehydrogenase family
AA2Tth_RS03310	COG1960	acyl-CoA dehydrogenase activity
AA2Tth_RS03325	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AA2Tth_RS03330	COG1293	RNA-binding protein homologous to eukaryotic snRNP
AA2Tth_RS03335	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AA2Tth_RS03345	COG3870	Protein conserved in bacteria
AA2Tth_RS03350	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AA2Tth_RS03370	COG0544	peptidyl-prolyl cis-trans isomerase activity
AA2Tth_RS03375	COG0740	serine-type endopeptidase activity
AA2Tth_RS03380	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AA2Tth_RS03385	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AA2Tth_RS03390	COG0646	methionine synthase
AA2Tth_RS03390	COG1410	methionine synthase
AA2Tth_RS03395	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AA2Tth_RS03420	COG1692	metallophosphoesterase
AA2Tth_RS03425	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AA2Tth_RS03455	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AA2Tth_RS03460	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AA2Tth_RS03525	COG0438	transferase activity, transferring glycosyl groups
AA2Tth_RS03550	COG0529	Catalyzes the synthesis of activated sulfate
AA2Tth_RS03555	COG2046	Belongs to the sulfate adenylyltransferase family
AA2Tth_RS03565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AA2Tth_RS03585	COG0489	protein tyrosine kinase activity
AA2Tth_RS03595	COG2264	protein methyltransferase activity
AA2Tth_RS03600	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AA2Tth_RS03630	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AA2Tth_RS03630	COG0574	Belongs to the PEP-utilizing enzyme family
AA2Tth_RS03640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA2Tth_RS03645	COG2046	Belongs to the sulfate adenylyltransferase family
AA2Tth_RS03650	COG1648	precorrin-2 dehydrogenase activity
AA2Tth_RS03650	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AA2Tth_RS03655	COG0730	response to heat
AA2Tth_RS03660	COG0175	sulfate reduction
AA2Tth_RS03665	COG1648	precorrin-2 dehydrogenase activity
AA2Tth_RS03665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AA2Tth_RS03670	COG1587	Uroporphyrinogen-III synthase
AA2Tth_RS03675	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AA2Tth_RS03685	COG0352	thiamine-phosphate diphosphorylase activity
AA2Tth_RS03690	COG2104	thiamine diphosphate biosynthetic process
AA2Tth_RS03695	COG2022	thiamine diphosphate biosynthetic process
AA2Tth_RS03700	COG2022	thiamine diphosphate biosynthetic process
AA2Tth_RS03700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2Tth_RS03705	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AA2Tth_RS03710	COG0477	Major facilitator Superfamily
AA2Tth_RS03715	COG0351	phosphomethylpyrimidine kinase
AA2Tth_RS03715	COG0352	thiamine-phosphate diphosphorylase activity
AA2Tth_RS03745	COG1175	transmembrane transport
AA2Tth_RS03755	COG1940	carbohydrate kinase activity
AA2Tth_RS03760	COG0183	Belongs to the thiolase family
AA2Tth_RS03775	COG1028	Short-chain dehydrogenase reductase Sdr
AA2Tth_RS03795	COG0559	Belongs to the binding-protein-dependent transport system permease family
AA2Tth_RS03810	COG2030	dehydratase
AA2Tth_RS03820	COG0596	Alpha beta hydrolase
AA2Tth_RS03825	COG0318	PFAM AMP-dependent synthetase and ligase
AA2Tth_RS03840	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AA2Tth_RS03840	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AA2Tth_RS03850	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AA2Tth_RS03860	COG0195	Participates in both transcription termination and antitermination
AA2Tth_RS03865	COG0779	Required for maturation of 30S ribosomal subunits
AA2Tth_RS03875	COG0739	heme binding
AA2Tth_RS03880	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AA2Tth_RS03885	COG0640	Transcriptional regulator
AA2Tth_RS03890	COG2217	Heavy metal translocating P-type atpase
AA2Tth_RS03895	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AA2Tth_RS03900	COG0017	Asparaginyl-tRNA synthetase
AA2Tth_RS03905	COG0561	phosphatase activity
AA2Tth_RS03910	COG0384	phenazine biosynthesis protein PhzF
AA2Tth_RS03920	COG0124	histidyl-tRNA synthetase
AA2Tth_RS03930	COG3842	ATPase activity
AA2Tth_RS03950	COG1573	uracil-dna glycosylase
AA2Tth_RS03970	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AA2Tth_RS03975	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AA2Tth_RS03975	COG0519	Catalyzes the synthesis of GMP from XMP
AA2Tth_RS03985	COG1316	TRANSCRIPTIONal
AA2Tth_RS03995	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AA2Tth_RS04040	COG0295	cytidine deaminase activity
AA2Tth_RS04060	COG1760	l-serine dehydratase
AA2Tth_RS04070	COG0481	GTPase activity
AA2Tth_RS04080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AA2Tth_RS04085	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AA2Tth_RS04095	COG1028	Short-chain dehydrogenase reductase Sdr
AA2Tth_RS04120	COG0405	Gamma-glutamyltransferase
AA2Tth_RS04130	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AA2Tth_RS04135	COG2873	o-acetylhomoserine
AA2Tth_RS04150	COG1063	alcohol dehydrogenase
AA2Tth_RS04160	COG3191	aminopeptidase activity
AA2Tth_RS04165	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AA2Tth_RS04175	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AA2Tth_RS04180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA2Tth_RS04185	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AA2Tth_RS04190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA2Tth_RS04200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA2Tth_RS04215	COG0167	dihydroorotate dehydrogenase activity
AA2Tth_RS04250	COG0730	response to heat
AA2Tth_RS04255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AA2Tth_RS04275	COG1960	acyl-CoA dehydrogenase activity
AA2Tth_RS04280	COG0456	acetyltransferase
AA2Tth_RS04290	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AA2Tth_RS04295	COG0009	L-threonylcarbamoyladenylate synthase
AA2Tth_RS04300	COG1459	type II secretion system
AA2Tth_RS04315	COG0277	FAD linked oxidase domain protein
AA2Tth_RS04325	COG0287	Prephenate dehydrogenase
AA2Tth_RS04330	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AA2Tth_RS04335	COG2514	catechol 2,3-dioxygenase activity
AA2Tth_RS04340	COG2353	YceI-like domain
AA2Tth_RS04345	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AA2Tth_RS04350	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AA2Tth_RS04370	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AA2Tth_RS04375	COG0179	Fumarylacetoacetate (FAA) hydrolase
AA2Tth_RS04385	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AA2Tth_RS04390	COG0151	Belongs to the GarS family
AA2Tth_RS04395	COG2176	DNA-directed DNA polymerase activity
AA2Tth_RS04395	COG5002	protein histidine kinase activity
AA2Tth_RS04425	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AA2Tth_RS04435	COG0217	transcriptional regulatory protein
AA2Tth_RS04440	COG4651	solute:proton antiporter activity
AA2Tth_RS04440	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AA2Tth_RS04445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AA2Tth_RS04450	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AA2Tth_RS04455	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AA2Tth_RS04460	COG1674	ftsk spoiiie
AA2Tth_RS04475	COG0517	IMP dehydrogenase activity
AA2Tth_RS04490	COG0617	tRNA 3'-terminal CCA addition
AA2Tth_RS04490	COG3620	sequence-specific DNA binding
AA2Tth_RS04490	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AA2Tth_RS04500	COG1994	Peptidase M50
AA2Tth_RS04505	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AA2Tth_RS04515	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AA2Tth_RS04530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AA2Tth_RS04535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AA2Tth_RS04540	COG2719	SpoVR family
AA2Tth_RS04545	COG2718	Belongs to the UPF0229 family
AA2Tth_RS04550	COG2766	serine protein kinase
AA2Tth_RS04575	COG2137	regulation of response to DNA damage stimulus
AA2Tth_RS04585	COG2359	stage V sporulation protein S
AA2Tth_RS04590	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AA2Tth_RS04595	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AA2Tth_RS04605	COG0463	Glycosyl transferase, family 2
AA2Tth_RS04610	COG0750	zinc metalloprotease
AA2Tth_RS04615	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AA2Tth_RS04620	COG0575	Belongs to the CDS family
AA2Tth_RS04625	COG0233	cytoplasmic translational termination
AA2Tth_RS04630	COG0528	UMP kinase activity
AA2Tth_RS04635	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AA2Tth_RS04640	COG0052	Belongs to the universal ribosomal protein uS2 family
AA2Tth_RS04650	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AA2Tth_RS04655	COG0494	nUDIX hydrolase
AA2Tth_RS04675	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AA2Tth_RS04685	COG0402	S-adenosylhomocysteine deaminase activity
AA2Tth_RS04695	COG4948	Mandelate Racemase Muconate Lactonizing
AA2Tth_RS04700	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AA2Tth_RS04705	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AA2Tth_RS04710	COG1811	Na channel or pump
AA2Tth_RS04715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2Tth_RS04715	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AA2Tth_RS04730	COG1215	transferase activity, transferring glycosyl groups
AA2Tth_RS04740	COG1215	transferase activity, transferring glycosyl groups
AA2Tth_RS04750	COG0438	transferase activity, transferring glycosyl groups
AA2Tth_RS04755	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AA2Tth_RS04770	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA2Tth_RS04770	COG1024	Enoyl-CoA hydratase
AA2Tth_RS04775	COG0183	Belongs to the thiolase family
AA2Tth_RS04780	COG1960	acyl-CoA dehydrogenase activity
AA2Tth_RS04785	COG0215	cysteine-tRNA ligase activity
AA2Tth_RS04790	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AA2Tth_RS04820	COG1196	nuclear chromosome segregation
AA2Tth_RS04835	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AA2Tth_RS04840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AA2Tth_RS04840	COG3153	acetyltransferase
AA2Tth_RS04845	COG1268	BioY protein
AA2Tth_RS04855	COG0126	phosphoglycerate kinase activity
AA2Tth_RS04860	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AA2Tth_RS04865	COG0824	Thioesterase
AA2Tth_RS04875	COG0557	exoribonuclease II activity
AA2Tth_RS04880	COG1355	regulation of microtubule-based process
AA2Tth_RS04885	COG1353	crispr-associated protein
AA2Tth_RS04885	COG0617	tRNA 3'-terminal CCA addition
AA2Tth_RS04890	COG0237	dephospho-CoA kinase activity
AA2Tth_RS04895	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AA2Tth_RS04905	COG0742	ribosomal rna small subunit methyltransferase
AA2Tth_RS04910	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AA2Tth_RS04915	COG0138	bifunctional purine biosynthesis protein purh
AA2Tth_RS04920	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AA2Tth_RS04935	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AA2Tth_RS04990	COG0149	triose-phosphate isomerase activity
AA2Tth_RS04995	COG3239	Fatty acid desaturase
AA2Tth_RS05010	COG1490	D-aminoacyl-tRNA deacylase activity
AA2Tth_RS05015	COG1307	EDD domain protein, DegV family
AA2Tth_RS05020	COG1307	EDD domain protein, DegV family
AA2Tth_RS05025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AA2Tth_RS05030	COG1510	regulation of RNA biosynthetic process
AA2Tth_RS05050	COG1136	(ABC) transporter
AA2Tth_RS05065	COG3769	mannosylglycerate metabolic process
AA2Tth_RS05075	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA2Tth_RS05085	COG1012	belongs to the aldehyde dehydrogenase family
AA2Tth_RS05090	COG2368	4-hydroxyphenylacetate
AA2Tth_RS05095	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AA2Tth_RS05125	COG2050	protein possibly involved in aromatic compounds catabolism
AA2Tth_RS05130	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AA2Tth_RS05140	COG1012	belongs to the aldehyde dehydrogenase family
AA2Tth_RS05140	COG2030	dehydratase
AA2Tth_RS05160	COG3396	Phenylacetate-CoA oxygenase
AA2Tth_RS05170	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AA2Tth_RS05180	COG0395	ABC-type sugar transport system, permease component
AA2Tth_RS05200	COG1980	fructose-bisphosphate aldolase activity
AA2Tth_RS05205	COG1733	regulation of RNA biosynthetic process
AA2Tth_RS05210	COG2193	ferroxidase activity
AA2Tth_RS05215	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AA2Tth_RS05220	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AA2Tth_RS05230	COG1331	Highly conserved protein containing a thioredoxin domain
AA2Tth_RS05235	COG0183	Belongs to the thiolase family
AA2Tth_RS05240	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AA2Tth_RS05245	COG0477	Major facilitator Superfamily
AA2Tth_RS05290	COG1012	belongs to the aldehyde dehydrogenase family
AA2Tth_RS05300	COG0248	Ppx GppA phosphatase
AA2Tth_RS05305	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AA2Tth_RS05310	COG0210	DNA helicase
AA2Tth_RS05325	COG1309	transcriptional regulator
AA2Tth_RS05330	COG1131	(ABC) transporter
AA2Tth_RS05335	COG0842	Transport permease protein
AA2Tth_RS05360	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AA2Tth_RS05385	COG0582	viral genome integration into host DNA
AA2Tth_RS05395	COG2897	thiosulfate sulfurtransferase activity
AA2Tth_RS05400	COG1760	l-serine dehydratase
AA2Tth_RS05405	COG2197	response regulator
AA2Tth_RS05410	COG0335	large ribosomal subunit rRNA binding
AA2Tth_RS05415	COG0336	Belongs to the RNA methyltransferase TrmD family
AA2Tth_RS05420	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AA2Tth_RS05425	COG1837	Belongs to the UPF0109 family
AA2Tth_RS05430	COG0228	four-way junction DNA binding
AA2Tth_RS05445	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AA2Tth_RS05450	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AA2Tth_RS05450	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AA2Tth_RS05455	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AA2Tth_RS05465	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AA2Tth_RS05475	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AA2Tth_RS05480	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AA2Tth_RS05485	COG1702	phosphate starvation-inducible protein PhoH
AA2Tth_RS05495	COG4864	UPF0365 protein
AA2Tth_RS05505	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AA2Tth_RS05515	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AA2Tth_RS05515	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AA2Tth_RS05520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AA2Tth_RS05530	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AA2Tth_RS05535	COG1397	ADP-ribosylglycohydrolase
AA2Tth_RS05540	COG2239	Acts as a magnesium transporter
AA2Tth_RS05545	COG2304	oxidoreductase activity
AA2Tth_RS05550	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AA2Tth_RS05550	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AA2Tth_RS05560	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AA2Tth_RS05560	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AA2Tth_RS05565	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AA2Tth_RS05570	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AA2Tth_RS05575	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AA2Tth_RS05580	COG0006	proline dipeptidase activity
AA2Tth_RS05590	COG0739	heme binding
AA2Tth_RS05600	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AA2Tth_RS05605	COG0254	rRNA binding
AA2Tth_RS05620	COG2001	Belongs to the MraZ family
AA2Tth_RS05625	COG0275	rRNA processing
AA2Tth_RS05640	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AA2Tth_RS05650	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AA2Tth_RS05655	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AA2Tth_RS05660	COG0772	Belongs to the SEDS family
AA2Tth_RS05665	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AA2Tth_RS05670	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AA2Tth_RS05675	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AA2Tth_RS05695	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AA2Tth_RS05710	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AA2Tth_RS05720	COG0159	tryptophan synthase activity
AA2Tth_RS05725	COG0133	tryptophan synthase activity
AA2Tth_RS05730	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AA2Tth_RS05735	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AA2Tth_RS05740	COG1744	ABC transporter substrate-binding protein PnrA-like
AA2Tth_RS05745	COG3845	ABC transporter
AA2Tth_RS05795	COG0438	transferase activity, transferring glycosyl groups
AA2Tth_RS05800	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AA2Tth_RS05810	COG0039	L-malate dehydrogenase activity
AA2Tth_RS05815	COG2819	hydrolase of the alpha beta superfamily
AA2Tth_RS05820	COG0861	Integral membrane protein TerC family
AA2Tth_RS05830	COG0247	lactate metabolic process
AA2Tth_RS05830	COG2181	nitrate reductase activity
AA2Tth_RS05840	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AA2Tth_RS05845	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AA2Tth_RS05850	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AA2Tth_RS05860	COG0439	Biotin carboxylase
AA2Tth_RS05865	COG0511	ligase activity, forming carbon-carbon bonds
AA2Tth_RS05870	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AA2Tth_RS05885	COG0010	Belongs to the arginase family
AA2Tth_RS05900	COG1100	Small GTP-binding protein
AA2Tth_RS05910	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AA2Tth_RS05915	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AA2Tth_RS05925	COG2814	Major facilitator Superfamily
AA2Tth_RS05930	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AA2Tth_RS05940	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AA2Tth_RS05945	COG0589	response to stress
AA2Tth_RS05960	COG3335	DDE superfamily endonuclease
AA2Tth_RS05970	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AA2Tth_RS05970	COG0617	tRNA 3'-terminal CCA addition
AA2Tth_RS05970	COG0517	IMP dehydrogenase activity
AA2Tth_RS05975	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AA2Tth_RS05980	COG0745	RESPONSE REGULATOR receiver
AA2Tth_RS05985	COG5002	protein histidine kinase activity
AA2Tth_RS05990	COG1960	acyl-CoA dehydrogenase activity
AA2Tth_RS05995	COG2086	electron transfer activity
AA2Tth_RS06000	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AA2Tth_RS06010	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AA2Tth_RS06015	COG1573	uracil-dna glycosylase
AA2Tth_RS06020	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AA2Tth_RS06020	COG1796	DNA polymerase
AA2Tth_RS06040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA2Tth_RS06050	COG1011	Hydrolase
AA2Tth_RS06070	COG2873	o-acetylhomoserine
AA2Tth_RS06075	COG2358	TRAP transporter, solute receptor (TAXI family
AA2Tth_RS06085	COG1126	abc transporter atp-binding protein
AA2Tth_RS06100	COG0134	indole-3-glycerol-phosphate synthase activity
AA2Tth_RS06105	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AA2Tth_RS06115	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AA2Tth_RS06130	COG0765	amino acid transport
AA2Tth_RS06135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA2Tth_RS06145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AA2Tth_RS06150	COG0569	domain protein
AA2Tth_RS06155	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AA2Tth_RS06160	COG1426	Protein conserved in bacteria
AA2Tth_RS06165	COG2313	pseudouridylate synthase activity
AA2Tth_RS06175	COG3001	Fructosamine kinase
AA2Tth_RS06180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AA2Tth_RS06190	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AA2Tth_RS06215	COG0012	GTP binding
AA2Tth_RS06220	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AA2Tth_RS06230	COG0424	maF-like protein
AA2Tth_RS06245	COG0768	penicillin binding
AA2Tth_RS06250	COG0850	regulation of cytokinetic process
AA2Tth_RS06255	COG2322	membrane
AA2Tth_RS06275	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AA2Tth_RS06280	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AA2Tth_RS06290	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AA2Tth_RS06310	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AA2Tth_RS06320	COG1131	(ABC) transporter
AA2Tth_RS06335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AA2Tth_RS06350	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AA2Tth_RS06355	COG0440	acetolactate synthase activity
AA2Tth_RS06360	COG0028	Belongs to the TPP enzyme family
AA2Tth_RS06370	COG0492	ferredoxin-NADP+ reductase activity
AA2Tth_RS06375	COG4970	Tfp pilus assembly protein FimT
AA2Tth_RS06380	COG4970	Tfp pilus assembly protein FimT
AA2Tth_RS06385	COG2165	general secretion pathway protein
AA2Tth_RS06390	COG4966	pilus assembly protein PilW
AA2Tth_RS06400	COG2165	general secretion pathway protein
AA2Tth_RS06415	COG4636	protein conserved in cyanobacteria
AA2Tth_RS06450	COG0180	Tryptophanyl-tRNA synthetase
AA2Tth_RS06455	COG0544	peptidyl-prolyl cis-trans isomerase activity
AA2Tth_RS06460	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AA2Tth_RS06465	COG0066	3-isopropylmalate dehydratase activity
AA2Tth_RS06470	COG0473	3-isopropylmalate dehydrogenase activity
AA2Tth_RS06485	COG0300	oxidoreductase activity
AA2Tth_RS06490	COG0129	dihydroxy-acid dehydratase activity
AA2Tth_RS06500	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AA2Tth_RS06505	COG1177	transmembrane transport
AA2Tth_RS06510	COG1176	ABC-type spermidine putrescine transport system, permease component I
AA2Tth_RS06515	COG3842	ATPase activity
AA2Tth_RS06520	COG0772	Belongs to the SEDS family
AA2Tth_RS06525	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AA2Tth_RS06530	COG2894	cell division
AA2Tth_RS06535	COG1733	regulation of RNA biosynthetic process
AA2Tth_RS06545	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AA2Tth_RS06545	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AA2Tth_RS06555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AA2Tth_RS06560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AA2Tth_RS06565	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AA2Tth_RS06570	COG0653	protein targeting
AA2Tth_RS06575	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AA2Tth_RS06595	COG0393	Putative heavy-metal-binding
AA2Tth_RS06600	COG1111	helicase
AA2Tth_RS06600	COG1205	dead DEAH box helicase
AA2Tth_RS06615	COG0358	DNA primase activity
AA2Tth_RS06630	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA2Tth_RS06635	COG0697	spore germination
AA2Tth_RS06640	COG0612	Peptidase, M16
AA2Tth_RS06645	COG0612	Peptidase, M16
AA2Tth_RS06650	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AA2Tth_RS06665	COG1394	ATPase activity, coupled to movement of substances
AA2Tth_RS06670	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
AA2Tth_RS06675	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
AA2Tth_RS06680	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
AA2Tth_RS06685	COG1527	subunit (C
AA2Tth_RS06690	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
AA2Tth_RS06700	COG1269	ATP hydrolysis coupled proton transport
AA2Tth_RS06735	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AA2Tth_RS06745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AA2Tth_RS06760	COG0419	ATPase involved in DNA repair
AA2Tth_RS06765	COG0420	3'-5' exonuclease activity
AA2Tth_RS06785	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AA2Tth_RS06790	COG2884	Cell division ATP-binding protein ftsE
AA2Tth_RS06795	COG0793	Belongs to the peptidase S41A family
AA2Tth_RS06800	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AA2Tth_RS06800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AA2Tth_RS06805	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AA2Tth_RS06810	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AA2Tth_RS06830	COG1079	Belongs to the binding-protein-dependent transport system permease family
AA2Tth_RS06835	COG4603	Belongs to the binding-protein-dependent transport system permease family
AA2Tth_RS06840	COG1129	ABC transporter
AA2Tth_RS06845	COG0746	molybdenum cofactor guanylyltransferase activity
AA2Tth_RS06860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AA2Tth_RS06880	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AA2Tth_RS06885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AA2Tth_RS06890	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AA2Tth_RS06900	COG1994	Peptidase M50
AA2Tth_RS06900	COG0517	IMP dehydrogenase activity
AA2Tth_RS06905	COG2358	TRAP transporter, solute receptor (TAXI family
AA2Tth_RS06915	COG2358	TRAP transporter, solute receptor (TAXI family
AA2Tth_RS06930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA2Tth_RS06935	COG0788	formyltetrahydrofolate deformylase activity
AA2Tth_RS06940	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AA2Tth_RS06945	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AA2Tth_RS06950	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AA2Tth_RS06970	COG0737	Belongs to the 5'-nucleotidase family
AA2Tth_RS06975	COG0174	glutamine synthetase
AA2Tth_RS06985	COG0559	Belongs to the binding-protein-dependent transport system permease family
AA2Tth_RS07005	COG0747	negative chemotaxis
AA2Tth_RS07010	COG0601	transmembrane transport
AA2Tth_RS07015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2Tth_RS07025	COG0285	dihydrofolate synthase activity
AA2Tth_RS07030	COG1132	(ABC) transporter
AA2Tth_RS07035	COG1132	(ABC) transporter
AA2Tth_RS07040	COG0372	Belongs to the citrate synthase family
AA2Tth_RS07045	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AA2Tth_RS07050	COG1482	cell wall glycoprotein biosynthetic process
AA2Tth_RS07060	COG1515	deoxyribonuclease V activity
AA2Tth_RS07070	COG0776	regulation of translation
AA2Tth_RS07085	COG2197	response regulator
AA2Tth_RS07090	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AA2Tth_RS07095	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AA2Tth_RS07100	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AA2Tth_RS07105	COG1324	tolerance protein
AA2Tth_RS07110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA2Tth_RS07130	COG2205	protein histidine kinase activity
AA2Tth_RS07145	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AA2Tth_RS07180	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AA2Tth_RS07185	COG0247	lactate metabolic process
AA2Tth_RS07190	COG1139	Iron-sulfur cluster binding protein
AA2Tth_RS07195	COG1556	Lactate utilization protein
AA2Tth_RS07205	COG1752	Esterase of the alpha-beta hydrolase superfamily
AA2Tth_RS07210	COG0515	serine threonine protein kinase
AA2Tth_RS07210	COG2815	serine threonine protein kinase
AA2Tth_RS07220	COG0860	N-Acetylmuramoyl-L-alanine amidase
AA2Tth_RS07230	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AA2Tth_RS07265	COG0473	3-isopropylmalate dehydrogenase activity
AA2Tth_RS07290	COG1450	Type ii and iii secretion system protein
AA2Tth_RS07295	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AA2Tth_RS07300	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AA2Tth_RS07305	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AA2Tth_RS07310	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AA2Tth_RS07310	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AA2Tth_RS07315	COG0736	holo-[acyl-carrier-protein] synthase activity
AA2Tth_RS07330	COG1160	GTP binding
AA2Tth_RS07335	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AA2Tth_RS07340	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AA2Tth_RS07340	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AA2Tth_RS07345	COG2814	Major facilitator Superfamily
AA2Tth_RS07350	COG0083	homoserine kinase activity
AA2Tth_RS07365	COG0268	Binds directly to 16S ribosomal RNA
AA2Tth_RS07375	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AA2Tth_RS07380	COG0723	plastoquinol--plastocyanin reductase activity
AA2Tth_RS07390	COG3088	subunit of a heme lyase
AA2Tth_RS07390	COG4235	cytochrome complex assembly
AA2Tth_RS07395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AA2Tth_RS07400	COG1138	Cytochrome C-type biogenesis protein
AA2Tth_RS07405	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AA2Tth_RS07410	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AA2Tth_RS07415	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AA2Tth_RS07420	COG4133	protoheme IX ABC transporter activity
AA2Tth_RS07425	COG0785	Cytochrome C biogenesis protein
AA2Tth_RS07430	COG3258	Cytochrome c
AA2Tth_RS07440	COG0446	pyridine nucleotide-disulphide oxidoreductase
AA2Tth_RS07455	COG3258	Cytochrome c
AA2Tth_RS07460	COG2010	Cytochrome c
AA2Tth_RS07465	COG0737	Belongs to the 5'-nucleotidase family
AA2Tth_RS07470	COG2010	Cytochrome c
AA2Tth_RS07475	COG3258	Cytochrome c
AA2Tth_RS07495	COG2010	Cytochrome c
AA2Tth_RS07500	COG3842	ATPase activity
AA2Tth_RS07530	COG0318	PFAM AMP-dependent synthetase and ligase
AA2Tth_RS07535	COG3360	Dodecin
AA2Tth_RS07550	COG1024	Enoyl-CoA hydratase
AA2Tth_RS07555	COG0813	purine-nucleoside phosphorylase activity
AA2Tth_RS07560	COG1136	(ABC) transporter
AA2Tth_RS07565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA2Tth_RS07570	COG2045	Belongs to the ComB family
AA2Tth_RS07580	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AA2Tth_RS07590	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AA2Tth_RS07595	COG0107	imidazoleglycerol-phosphate synthase activity
AA2Tth_RS07600	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AA2Tth_RS07600	COG0140	phosphoribosyl-ATP diphosphatase activity
AA2Tth_RS07605	COG1494	fructose-1,6-bisphosphatase
AA2Tth_RS07610	COG0686	Belongs to the AlaDH PNT family
AA2Tth_RS07615	COG0427	acetyl-CoA hydrolase
AA2Tth_RS07625	COG0084	hydrolase, TatD family'
AA2Tth_RS07630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AA2Tth_RS07640	COG0017	Asparaginyl-tRNA synthetase
AA2Tth_RS07655	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AA2Tth_RS07670	COG2009	succinate dehydrogenase
AA2Tth_RS07675	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AA2Tth_RS07705	COG0318	PFAM AMP-dependent synthetase and ligase
AA2Tth_RS07710	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AA2Tth_RS07715	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AA2Tth_RS07720	COG0504	CTP synthase activity
AA2Tth_RS07745	COG0067	glutamate synthase
AA2Tth_RS07745	COG0069	glutamate synthase activity
AA2Tth_RS07745	COG0070	glutamate synthase
AA2Tth_RS07795	COG0840	transmembrane signaling receptor activity
AA2Tth_RS07800	COG0305	Participates in initiation and elongation during chromosome replication
AA2Tth_RS07810	COG0475	glutathione-regulated potassium exporter activity
AA2Tth_RS07815	COG0517	IMP dehydrogenase activity
AA2Tth_RS07815	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AA2Tth_RS07815	COG0617	tRNA 3'-terminal CCA addition
AA2Tth_RS07830	COG0475	glutathione-regulated potassium exporter activity
AA2Tth_RS07835	COG0490	domain, Protein
AA2Tth_RS07855	COG3118	belongs to the thioredoxin family
AA2Tth_RS07895	COG0542	response to heat
AA2Tth_RS07900	COG0789	Transcriptional regulator
AA2Tth_RS07905	COG0484	heat shock protein binding
AA2Tth_RS07910	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AA2Tth_RS07915	COG0443	Heat shock 70 kDa protein
AA2Tth_RS07920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AA2Tth_RS07925	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AA2Tth_RS07930	COG0616	signal peptide processing
AA2Tth_RS07935	COG1714	RDD family
AA2Tth_RS07945	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
AA2Tth_RS07950	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AA2Tth_RS07955	COG0714	Associated with various cellular activities
AA2Tth_RS07960	COG0574	Belongs to the PEP-utilizing enzyme family
AA2Tth_RS07960	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AA2Tth_RS07975	COG5002	protein histidine kinase activity
AA2Tth_RS07975	COG3850	Histidine kinase
AA2Tth_RS08000	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AA2Tth_RS08015	COG1011	Hydrolase
AA2Tth_RS08040	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AA2Tth_RS08055	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AA2Tth_RS08065	COG0047	phosphoribosylformylglycinamidine synthase activity
AA2Tth_RS08075	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AA2Tth_RS08080	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AA2Tth_RS08085	COG0116	Belongs to the methyltransferase superfamily
AA2Tth_RS08100	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AA2Tth_RS08105	COG0497	DNA recombination
AA2Tth_RS08115	COG0604	alcohol dehydrogenase
AA2Tth_RS08135	COG0585	pseudouridine synthase activity
AA2Tth_RS08160	COG1595	DNA-templated transcription, initiation
AA2Tth_RS08165	COG0557	exoribonuclease II activity
AA2Tth_RS08170	COG0538	isocitrate dehydrogenase activity
AA2Tth_RS08175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2Tth_RS08175	COG2022	thiamine diphosphate biosynthetic process
AA2Tth_RS08185	COG0582	viral genome integration into host DNA
AA2Tth_RS08230	COG0037	tRNA processing
AA2Tth_RS08230	COG0590	tRNA wobble adenosine to inosine editing
AA2Tth_RS08255	COG2050	protein possibly involved in aromatic compounds catabolism
AA2Tth_RS08265	COG0322	excinuclease ABC activity
AA2Tth_RS08270	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AA2Tth_RS08275	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AA2Tth_RS08280	COG1854	S-ribosylhomocysteine lyase activity
AA2Tth_RS08295	COG0519	Catalyzes the synthesis of GMP from XMP
AA2Tth_RS08295	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AA2Tth_RS08300	COG4636	protein conserved in cyanobacteria
AA2Tth_RS08305	COG4274	PFAM GYD family protein
AA2Tth_RS08310	COG0346	lactoylglutathione lyase activity
AA2Tth_RS08325	COG0328	RNA-DNA hybrid ribonuclease activity
AA2Tth_RS08330	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AA2Tth_RS08335	COG2095	MarC family integral membrane protein
AA2Tth_RS08340	COG1438	arginine binding
AA2Tth_RS08345	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AA2Tth_RS08350	COG1758	RNA polymerase activity
AA2Tth_RS08355	COG0194	GDP metabolic process
AA2Tth_RS08365	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AA2Tth_RS08370	COG2385	sporulation resulting in formation of a cellular spore
AA2Tth_RS08375	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
AA2Tth_RS08385	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AA2Tth_RS08425	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AA2Tth_RS08430	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AA2Tth_RS08435	COG1012	belongs to the aldehyde dehydrogenase family
AA2Tth_RS08440	COG0506	proline dehydrogenase activity
AA2Tth_RS08455	COG0156	8-amino-7-oxononanoate synthase activity
AA2Tth_RS08460	COG0827	DNA restriction-modification system
AA2Tth_RS08460	COG0732	type I restriction modification DNA specificity domain
AA2Tth_RS08470	COG0187	DNA topoisomerase II activity
AA2Tth_RS08475	COG1181	Belongs to the D-alanine--D-alanine ligase family
AA2Tth_RS08480	COG0193	aminoacyl-tRNA hydrolase activity
AA2Tth_RS08485	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AA2Tth_RS08510	COG2815	serine threonine protein kinase
AA2Tth_RS08510	COG0515	serine threonine protein kinase
AA2Tth_RS08515	COG0631	protein serine/threonine phosphatase activity
AA2Tth_RS08525	COG2814	Major facilitator Superfamily
AA2Tth_RS08530	COG0113	porphobilinogen synthase activity
AA2Tth_RS08535	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AA2Tth_RS08540	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AA2Tth_RS08565	COG4946	Tricorn protease homolog
AA2Tth_RS08565	COG1506	peptidase
AA2Tth_RS08565	COG0823	Involved in the tonB-independent uptake of proteins
AA2Tth_RS08570	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AA2Tth_RS08575	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AA2Tth_RS08595	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AA2Tth_RS08600	COG1011	Hydrolase
AA2Tth_RS08625	COG0537	adenosine 5'-monophosphoramidase activity
AA2Tth_RS08630	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AA2Tth_RS08635	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AA2Tth_RS08640	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AA2Tth_RS08645	COG0071	Belongs to the small heat shock protein (HSP20) family
AA2Tth_RS08650	COG2897	thiosulfate sulfurtransferase activity
AA2Tth_RS08655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AA2Tth_RS08665	COG1764	response to oxidative stress
AA2Tth_RS08690	COG3842	ATPase activity
AA2Tth_RS08695	COG0101	tRNA pseudouridine synthase activity
AA2Tth_RS08700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA2Tth_RS08705	COG0601	transmembrane transport
AA2Tth_RS08725	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AA2Tth_RS08740	COG1166	arginine decarboxylase activity
AA2Tth_RS08745	COG3706	GGDEF domain
AA2Tth_RS08750	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AA2Tth_RS08755	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AA2Tth_RS08760	COG1611	Belongs to the LOG family
AA2Tth_RS08765	COG1193	negative regulation of DNA recombination
AA2Tth_RS08770	COG0366	Alpha amylase catalytic
AA2Tth_RS08805	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AA2Tth_RS08810	COG0142	geranyltranstransferase activity
AA2Tth_RS08825	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AA2Tth_RS08855	COG0203	ribosomal protein L17
AA2Tth_RS08860	COG0202	RNA polymerase activity
AA2Tth_RS08865	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AA2Tth_RS08870	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AA2Tth_RS08875	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AA2Tth_RS08885	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AA2Tth_RS08895	COG0563	adenylate kinase activity
AA2Tth_RS08900	COG0201	protein transport
AA2Tth_RS08925	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AA2Tth_RS08930	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AA2Tth_RS08935	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AA2Tth_RS08960	COG0255	Belongs to the universal ribosomal protein uL29 family
AA2Tth_RS08965	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AA2Tth_RS08970	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AA2Tth_RS08980	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AA2Tth_RS08985	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AA2Tth_RS08990	COG0089	rRNA binding
AA2Tth_RS08995	COG0088	Forms part of the polypeptide exit tunnel
AA2Tth_RS09005	COG0051	transcription antitermination factor activity, RNA binding
AA2Tth_RS09010	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AA2Tth_RS09015	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AA2Tth_RS09020	COG0049	tRNA binding
AA2Tth_RS09035	COG0442	prolyl-tRNA aminoacylation
AA2Tth_RS09045	COG1115	amino acid carrier protein
AA2Tth_RS09065	COG1489	DNA binding
AA2Tth_RS09090	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AA2Tth_RS09110	COG0432	Pfam Uncharacterised protein family UPF0047
AA2Tth_RS09115	COG3253	May function as heme-dependent peroxidase
AA2Tth_RS09120	COG0668	transmembrane transport
AA2Tth_RS09130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AA2Tth_RS09135	COG2217	Heavy metal translocating P-type atpase
AA2Tth_RS09160	COG3335	DDE superfamily endonuclease
AA2Tth_RS09165	COG0745	RESPONSE REGULATOR receiver
AA2Tth_RS09170	COG2205	protein histidine kinase activity
AA2Tth_RS09195	COG2226	methyltransferase
AA2Tth_RS09215	COG2132	Multicopper oxidase
AA2Tth_RS09225	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AA2Tth_RS09230	COG0822	iron-sulfur transferase activity
AA2Tth_RS09250	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AA2Tth_RS09260	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AA2Tth_RS09265	COG0284	orotidine-5'-phosphate decarboxylase activity
AA2Tth_RS09275	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AA2Tth_RS09285	COG0416	fatty acid biosynthetic process
AA2Tth_RS09290	COG3118	belongs to the thioredoxin family
AA2Tth_RS09295	COG1185	polyribonucleotide nucleotidyltransferase activity
AA2Tth_RS09300	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AA2Tth_RS09310	COG0438	transferase activity, transferring glycosyl groups
AA2Tth_RS09330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AA2Tth_RS09335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AA2Tth_RS09340	COG3706	GGDEF domain
AA2Tth_RS09375	COG0437	4 iron, 4 sulfur cluster binding
AA2Tth_RS09390	COG0825	malonyl-CoA metabolic process
AA2Tth_RS09395	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AA2Tth_RS09430	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AA2Tth_RS09455	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AA2Tth_RS09460	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AA2Tth_RS09465	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AA2Tth_RS09470	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AA2Tth_RS09490	COG4974	Belongs to the 'phage' integrase family
AA2Tth_RS09570	COG0315	cyclic pyranopterin monophosphate synthase activity
AA2Tth_RS09575	COG2860	membrane
AA2Tth_RS09580	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AA2Tth_RS09595	COG0477	Major facilitator Superfamily
AA2Tth_RS09600	COG1694	Mazg nucleotide pyrophosphohydrolase
AA2Tth_RS09605	COG1803	Methylglyoxal synthase
AA2Tth_RS09615	COG0301	tRNA thio-modification
AA2Tth_RS09620	COG0154	amidase activity
AA2Tth_RS09625	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AA2Tth_RS09645	COG2154	pterin-4-alpha-carbinolamine dehydratase
AA2Tth_RS09650	COG1607	acyl-coa hydrolase
AA2Tth_RS09660	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AA2Tth_RS09665	COG4149	molybdate abc transporter
AA2Tth_RS09670	COG1840	ABC-type Fe3 transport system, periplasmic component
AA2Tth_RS09685	COG0235	Class ii aldolase
AA2Tth_RS09690	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AA2Tth_RS09695	COG0085	RNA polymerase activity
AA2Tth_RS09705	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AA2Tth_RS09710	COG1077	Cell shape determining protein MreB Mrl
AA2Tth_RS09715	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AA2Tth_RS09715	COG1418	mRNA catabolic process
AA2Tth_RS09720	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AA2Tth_RS09725	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AA2Tth_RS09730	COG1058	Belongs to the CinA family
AA2Tth_RS09730	COG1546	Belongs to the CinA family
AA2Tth_RS09735	COG0354	folic acid binding
AA2Tth_RS09750	COG4948	Mandelate Racemase Muconate Lactonizing
AA2Tth_RS09765	COG1175	transmembrane transport
AA2Tth_RS09775	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AA2Tth_RS09785	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AA2Tth_RS09795	COG1136	(ABC) transporter
AA2Tth_RS09795	COG0577	efflux transmembrane transporter activity
AA2Tth_RS09800	COG4181	ATPase activity
AA2Tth_RS09805	COG0446	pyridine nucleotide-disulphide oxidoreductase
AA2Tth_RS09820	COG0396	ATPase activity
AA2Tth_RS09825	COG0719	Fe-S assembly protein
AA2Tth_RS09830	COG0719	Fe-S assembly protein
AA2Tth_RS09835	COG2146	nitrite reductase [NAD(P)H] activity
AA2Tth_RS09845	COG0512	Glutamine amidotransferase of anthranilate synthase
AA2Tth_RS09850	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AA2Tth_RS09885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AA2Tth_RS09890	COG2226	methyltransferase
AA2Tth_RS09895	COG4603	Belongs to the binding-protein-dependent transport system permease family
AA2Tth_RS09900	COG1079	Belongs to the binding-protein-dependent transport system permease family
AA2Tth_RS09915	COG1774	PSP1 C-terminal conserved region
AA2Tth_RS09920	COG0470	DNA polymerase III
AA2Tth_RS09955	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AA2Tth_RS09960	COG0302	gtp cyclohydrolase
AA2Tth_RS09985	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AA2Tth_RS09995	COG0395	ABC-type sugar transport system, permease component
AA2Tth_RS10010	COG1131	(ABC) transporter
AA2Tth_RS10040	COG0556	nucleotide-excision repair
AA2Tth_RS10045	COG0497	DNA recombination
AA2Tth_RS10050	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AA2Tth_RS10060	COG0445	tRNA wobble uridine modification
AA2Tth_RS10080	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AA2Tth_RS10080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AA2Tth_RS10085	COG1543	Belongs to the glycosyl hydrolase 57 family
AA2Tth_RS10090	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AA2Tth_RS10095	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AA2Tth_RS10100	COG0189	ligase activity
AA2Tth_RS10115	COG0066	3-isopropylmalate dehydratase activity
AA2Tth_RS10120	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AA2Tth_RS10135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AA2Tth_RS10140	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AA2Tth_RS10145	COG1960	acyl-CoA dehydrogenase activity
AA2Tth_RS10150	COG0163	prenyltransferase activity
AA2Tth_RS10195	COG2096	Adenosyltransferase
AA2Tth_RS10220	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AA2Tth_RS10225	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AA2Tth_RS10235	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AA2Tth_RS10240	COG0723	plastoquinol--plastocyanin reductase activity
AA2Tth_RS10265	COG1653	transport
AA2Tth_RS10270	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AA2Tth_RS10275	COG1960	acyl-CoA dehydrogenase activity
AA2Tth_RS10285	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AA2Tth_RS10315	COG1131	(ABC) transporter
AA2Tth_RS10340	COG3956	TIGRFAM MazG family protein
AA2Tth_RS10350	COG0693	protein deglycase activity
AA2Tth_RS10355	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AA2Tth_RS10365	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AA2Tth_RS10370	COG1937	Protein conserved in bacteria
AA2Tth_RS10380	COG0674	pyruvate-flavodoxin oxidoreductase activity
AA2Tth_RS10380	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AA2Tth_RS10385	COG1013	pyruvate-flavodoxin oxidoreductase activity
AA2Tth_RS10390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA2Tth_RS10410	COG0205	6-phosphofructokinase activity
AA2Tth_RS10415	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AA2Tth_RS10425	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AA2Tth_RS10440	COG2333	competence protein COMEC
AA2Tth_RS10440	COG0658	competence protein
AA2Tth_RS10445	COG1475	DNA binding
AA2Tth_RS10450	COG1192	Involved in chromosome partitioning
AA2Tth_RS10455	COG0357	Ribosomal RNA small subunit methyltransferase G
AA2Tth_RS10460	COG0445	tRNA wobble uridine modification
AA2Tth_RS10470	COG3335	DDE superfamily endonuclease
AA2Tth_RS10475	COG2211	Major facilitator Superfamily
AA2Tth_RS10500	COG2211	Major facilitator Superfamily
AA2Tth_RS10510	COG0739	heme binding
AA2Tth_RS10590	COG1609	Transcriptional regulator
AA2Tth_RS10610	COG0863	Belongs to the N(4) N(6)-methyltransferase family
AA2Tth_RS10635	COG1857	crispr-associated protein
AA2Tth_RS10655	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AA2Tth_RS10660	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AA2Tth_RS10690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA2Tth_RS10705	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AA2Tth_RS10710	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AA2Tth_RS10780	COG2205	protein histidine kinase activity
AA2Tth_RS10785	COG0745	RESPONSE REGULATOR receiver
AA2Tth_RS10790	COG2010	Cytochrome c
AA2Tth_RS10830	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AA2Tth_RS10835	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AA2Tth_RS10840	COG0363	glucosamine-6-phosphate deaminase activity
AA2Tth_RS10855	COG0730	response to heat
AA2Tth_RS10885	COG0671	phosphoesterase, PA-phosphatase related
AA2Tth_RS10895	COG0642	Histidine kinase
AA2Tth_RS10900	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AA2Tth_RS10910	COG1914	H( )-stimulated, divalent metal cation uptake system
AA2Tth_RS10930	COG2329	Antibiotic biosynthesis monooxygenase
AA2Tth_RS11015	COG0745	RESPONSE REGULATOR receiver
AA2Tth_RS11020	COG3850	Histidine kinase
AA2Tth_RS11020	COG5002	protein histidine kinase activity
AA2Tth_RS11080	COG1942	4-Oxalocrotonate Tautomerase
AA2Tth_RS11090	COG2084	Dehydrogenase
AA2Tth_RS11135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA2Tth_RS11170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA2Tth_RS11205	COG1252	NADH dehydrogenase
AA2Tth_RS11210	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AA2Tth_RS11220	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AA2Tth_RS11280	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA2Tth_RS11300	COG2010	Cytochrome c
AA2Tth_RS11305	COG0535	radical SAM domain protein
AA2Tth_RS11320	COG3256	nitric oxide reductase
AA2Tth_RS11370	COG1192	Involved in chromosome partitioning
AA2Tth_RS11375	COG1475	DNA binding
AA2Tth_RS11385	COG1475	DNA binding
AA2Tth_RS11405	COG3345	alpha-galactosidase
AA2Tth_RS11410	COG1085	galactose-1-phosphate uridylyltransferase
AA2Tth_RS11440	COG1304	FMN binding
AA2Tth_RS11450	COG1487	ribonuclease activity
AA2Tth_RS11475	COG2124	cytochrome p450
AA2Tth_RS11485	COG1562	ergosterol biosynthetic process
AA2Tth_RS11495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA2Tth_RS11505	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AA2Tth_RS11520	COG1175	transmembrane transport
AA2Tth_RS11535	COG1028	Short-chain dehydrogenase reductase Sdr
AA2Tth_RS11540	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AA2Tth_RS11555	COG0800	Aldolase
AA2Tth_RS11590	COG1028	Short-chain dehydrogenase reductase Sdr
AA2Tth_RS11595	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AA2Tth_RS11600	COG1785	Belongs to the alkaline phosphatase family
AA2Tth_RS11605	COG1492	cobalamin metabolic process
AA2Tth_RS11640	COG0778	Nitroreductase
AA2Tth_RS11645	COG1648	precorrin-2 dehydrogenase activity
AA2Tth_RS11645	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AA2Tth_RS11690	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
AA2Tth_RS11695	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
AA2Tth_RS11700	COG0588	phosphoglycerate mutase activity
AA2Tth_RS11715	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AA2Tth_RS11725	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AA2Tth_RS11730	COG1797	cobyrinic acid a,c-diamide synthase activity