locus-tag	class	description
TT_RS00010	COG1028	Short-chain dehydrogenase reductase Sdr
TT_RS00015	COG0492	ferredoxin-NADP+ reductase activity
TT_RS00025	COG0792	nuclease activity
TT_RS00030	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TT_RS00045	COG1175	transmembrane transport
TT_RS00050	COG0395	ABC-type sugar transport system, permease component
TT_RS00080	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TT_RS00085	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TT_RS00090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TT_RS00095	COG0805	protein transport
TT_RS00100	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TT_RS00100	COG1605	Chorismate mutase
TT_RS00155	COG1063	alcohol dehydrogenase
TT_RS00185	COG2255	four-way junction helicase activity
TT_RS00190	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TT_RS00195	COG0564	pseudouridine synthase activity
TT_RS00210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TT_RS00215	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TT_RS00220	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TT_RS00225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TT_RS00235	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TT_RS00240	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TT_RS00245	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TT_RS00280	COG0778	Nitroreductase
TT_RS00295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TT_RS00300	COG0131	Imidazoleglycerol-phosphate dehydratase
TT_RS00305	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TT_RS00310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TT_RS00315	COG0517	IMP dehydrogenase activity
TT_RS00315	COG0516	GMP reductase activity
TT_RS00330	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TT_RS00345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TT_RS00365	COG0706	membrane insertase activity
TT_RS00370	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TT_RS00375	COG0594	ribonuclease P activity
TT_RS00380	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TT_RS00390	COG1022	Amp-dependent synthetase and ligase
TT_RS00415	COG1121	(ABC) transporter
TT_RS00420	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TT_RS00425	COG1959	2 iron, 2 sulfur cluster binding
TT_RS00430	COG1104	cysteine desulfurase activity
TT_RS00435	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TT_RS00440	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TT_RS00455	COG1028	Short-chain dehydrogenase reductase Sdr
TT_RS00480	COG0492	ferredoxin-NADP+ reductase activity
TT_RS00485	COG3321	synthase
TT_RS00485	COG0604	alcohol dehydrogenase
TT_RS00485	COG1028	Short-chain dehydrogenase reductase Sdr
TT_RS00490	COG0747	negative chemotaxis
TT_RS00495	COG0601	transmembrane transport
TT_RS00500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TT_RS00515	COG0517	IMP dehydrogenase activity
TT_RS00520	COG0123	including yeast histone deacetylase and acetoin utilization protein
TT_RS00525	COG2104	thiamine diphosphate biosynthetic process
TT_RS00530	COG0037	tRNA processing
TT_RS00535	COG0366	Alpha amylase catalytic
TT_RS00540	COG2226	methyltransferase
TT_RS00545	COG2226	methyltransferase
TT_RS00570	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TT_RS00575	COG3744	PilT protein domain protein
TT_RS00585	COG0460	homoserine dehydrogenase
TT_RS00595	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TT_RS00635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TT_RS00655	COG0247	lactate metabolic process
TT_RS00665	COG0277	FAD linked oxidase domain protein
TT_RS00670	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TT_RS00675	COG1414	Transcriptional regulator
TT_RS00680	COG0789	Transcriptional regulator
TT_RS00690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TT_RS00695	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TT_RS00730	COG0861	Integral membrane protein TerC family
TT_RS00735	COG2151	metal-sulfur cluster biosynthetic enzyme
TT_RS00740	COG0281	malic enzyme
TT_RS00755	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TT_RS00760	COG0509	glycine decarboxylation via glycine cleavage system
TT_RS00765	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TT_RS00770	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TT_RS00775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TT_RS00790	COG0243	molybdopterin cofactor binding
TT_RS00810	COG0196	riboflavin kinase activity
TT_RS00835	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TT_RS00840	COG2813	Specifically methylates the guanine in position
TT_RS00845	COG0527	aspartate kinase activity
TT_RS00875	COG4956	integral membrane protein (PIN domain superfamily)
TT_RS00880	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TT_RS00885	COG0542	response to heat
TT_RS00890	COG0423	glycine-tRNA ligase activity
TT_RS00900	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TT_RS00920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TT_RS00930	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TT_RS00940	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TT_RS00950	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TT_RS00955	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TT_RS00960	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TT_RS00965	COG0114	fumarate hydratase activity
TT_RS00970	COG0183	Belongs to the thiolase family
TT_RS00985	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TT_RS00990	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TT_RS01005	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TT_RS01010	COG1254	Belongs to the acylphosphatase family
TT_RS01020	COG1063	alcohol dehydrogenase
TT_RS01025	COG2133	pyrroloquinoline quinone binding
TT_RS01035	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TT_RS01040	COG0154	amidase activity
TT_RS01065	COG0572	uridine kinase
TT_RS01070	COG3842	ATPase activity
TT_RS01085	COG4475	Protein of unknown function (DUF436)
TT_RS01140	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TT_RS01145	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TT_RS01150	COG0803	Belongs to the bacterial solute-binding protein 9 family
TT_RS01165	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TT_RS01170	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TT_RS01175	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TT_RS01180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TT_RS01190	COG1028	Short-chain dehydrogenase reductase Sdr
TT_RS01195	COG0318	PFAM AMP-dependent synthetase and ligase
TT_RS01200	COG2030	dehydratase
TT_RS01200	COG1012	belongs to the aldehyde dehydrogenase family
TT_RS01205	COG1960	acyl-CoA dehydrogenase activity
TT_RS01220	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TT_RS01225	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TT_RS01230	COG1293	RNA-binding protein homologous to eukaryotic snRNP
TT_RS01235	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TT_RS01245	COG3870	Protein conserved in bacteria
TT_RS01250	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TT_RS01270	COG0544	peptidyl-prolyl cis-trans isomerase activity
TT_RS01275	COG0740	serine-type endopeptidase activity
TT_RS01280	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TT_RS01285	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TT_RS01290	COG0646	methionine synthase
TT_RS01290	COG1410	methionine synthase
TT_RS01300	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TT_RS01325	COG1692	metallophosphoesterase
TT_RS01330	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TT_RS01335	COG1970	mechanosensitive ion channel activity
TT_RS01355	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TT_RS01365	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TT_RS01370	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TT_RS01420	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TT_RS01435	COG1215	transferase activity, transferring glycosyl groups
TT_RS01485	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TT_RS01505	COG0489	protein tyrosine kinase activity
TT_RS01515	COG2264	protein methyltransferase activity
TT_RS01520	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TT_RS01550	COG0574	Belongs to the PEP-utilizing enzyme family
TT_RS01550	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TT_RS01560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TT_RS01565	COG2046	Belongs to the sulfate adenylyltransferase family
TT_RS01570	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TT_RS01570	COG1648	precorrin-2 dehydrogenase activity
TT_RS01575	COG0730	response to heat
TT_RS01580	COG0175	sulfate reduction
TT_RS01585	COG1648	precorrin-2 dehydrogenase activity
TT_RS01585	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TT_RS01590	COG1587	Uroporphyrinogen-III synthase
TT_RS01595	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TT_RS01605	COG0352	thiamine-phosphate diphosphorylase activity
TT_RS01610	COG2104	thiamine diphosphate biosynthetic process
TT_RS01615	COG2022	thiamine diphosphate biosynthetic process
TT_RS01620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TT_RS01620	COG2022	thiamine diphosphate biosynthetic process
TT_RS01625	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TT_RS01630	COG0477	Major facilitator Superfamily
TT_RS01635	COG0351	phosphomethylpyrimidine kinase
TT_RS01635	COG0352	thiamine-phosphate diphosphorylase activity
TT_RS01665	COG1175	transmembrane transport
TT_RS01675	COG1940	carbohydrate kinase activity
TT_RS01680	COG0183	Belongs to the thiolase family
TT_RS01695	COG1028	Short-chain dehydrogenase reductase Sdr
TT_RS01725	COG2030	dehydratase
TT_RS01735	COG0596	Alpha beta hydrolase
TT_RS01740	COG0318	PFAM AMP-dependent synthetase and ligase
TT_RS01755	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TT_RS01755	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TT_RS01765	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TT_RS01775	COG0195	Participates in both transcription termination and antitermination
TT_RS01780	COG0779	Required for maturation of 30S ribosomal subunits
TT_RS01785	COG0739	heme binding
TT_RS01790	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TT_RS01795	COG0640	Transcriptional regulator
TT_RS01800	COG2217	Heavy metal translocating P-type atpase
TT_RS01805	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TT_RS01810	COG0017	Asparaginyl-tRNA synthetase
TT_RS01815	COG0561	phosphatase activity
TT_RS01820	COG0384	phenazine biosynthesis protein PhzF
TT_RS01830	COG0124	histidyl-tRNA synthetase
TT_RS01840	COG3842	ATPase activity
TT_RS01855	COG1573	uracil-dna glycosylase
TT_RS01875	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TT_RS01880	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TT_RS01880	COG0519	Catalyzes the synthesis of GMP from XMP
TT_RS01890	COG1316	TRANSCRIPTIONal
TT_RS01900	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TT_RS01945	COG0295	cytidine deaminase activity
TT_RS01955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TT_RS01965	COG1760	l-serine dehydratase
TT_RS01975	COG0481	GTPase activity
TT_RS01985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TT_RS01990	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TT_RS02000	COG1028	Short-chain dehydrogenase reductase Sdr
TT_RS02040	COG3706	GGDEF domain
TT_RS02045	COG0405	Gamma-glutamyltransferase
TT_RS02050	COG1073	alpha beta
TT_RS02065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TT_RS02070	COG2873	o-acetylhomoserine
TT_RS02085	COG1063	alcohol dehydrogenase
TT_RS02100	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TT_RS02110	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TT_RS02115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TT_RS02120	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TT_RS02125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TT_RS02135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TT_RS02140	COG5001	Diguanylate cyclase
TT_RS02140	COG3300	MHYT domain
TT_RS02150	COG0167	dihydroorotate dehydrogenase activity
TT_RS02160	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TT_RS02165	COG0540	Belongs to the ATCase OTCase family
TT_RS02170	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TT_RS02180	COG0730	response to heat
TT_RS02185	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TT_RS02195	COG0312	modulator of DNA gyrase
TT_RS02205	COG1960	acyl-CoA dehydrogenase activity
TT_RS02210	COG0456	acetyltransferase
TT_RS02220	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TT_RS02225	COG0009	L-threonylcarbamoyladenylate synthase
TT_RS02230	COG1459	type II secretion system
TT_RS02245	COG0277	FAD linked oxidase domain protein
TT_RS02265	COG0287	Prephenate dehydrogenase
TT_RS02270	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TT_RS02275	COG2514	catechol 2,3-dioxygenase activity
TT_RS02280	COG2353	YceI-like domain
TT_RS02285	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TT_RS02290	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TT_RS02310	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TT_RS02315	COG0179	Fumarylacetoacetate (FAA) hydrolase
TT_RS02325	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TT_RS02330	COG0151	Belongs to the GarS family
TT_RS02335	COG2176	DNA-directed DNA polymerase activity
TT_RS02335	COG5002	protein histidine kinase activity
TT_RS02365	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TT_RS02375	COG0217	transcriptional regulatory protein
TT_RS02385	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TT_RS02390	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TT_RS02395	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TT_RS02400	COG1674	ftsk spoiiie
TT_RS02415	COG0517	IMP dehydrogenase activity
TT_RS02430	COG3620	sequence-specific DNA binding
TT_RS02430	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TT_RS02430	COG0617	tRNA 3'-terminal CCA addition
TT_RS02440	COG1994	Peptidase M50
TT_RS02445	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TT_RS02455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TT_RS02470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TT_RS02480	COG2719	SpoVR family
TT_RS02485	COG2718	Belongs to the UPF0229 family
TT_RS02490	COG2766	serine protein kinase
TT_RS02515	COG2137	regulation of response to DNA damage stimulus
TT_RS02525	COG2359	stage V sporulation protein S
TT_RS02530	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TT_RS02535	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TT_RS02545	COG0463	Glycosyl transferase, family 2
TT_RS02550	COG0750	zinc metalloprotease
TT_RS02555	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TT_RS02560	COG4589	Belongs to the CDS family
TT_RS02565	COG0233	cytoplasmic translational termination
TT_RS02570	COG0528	UMP kinase activity
TT_RS02575	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TT_RS02580	COG0052	Belongs to the universal ribosomal protein uS2 family
TT_RS02590	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TT_RS02595	COG0494	nUDIX hydrolase
TT_RS02620	COG0402	S-adenosylhomocysteine deaminase activity
TT_RS02630	COG4948	Mandelate Racemase Muconate Lactonizing
TT_RS02635	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TT_RS02640	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TT_RS02645	COG1811	Na channel or pump
TT_RS02650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TT_RS02650	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TT_RS02665	COG1215	transferase activity, transferring glycosyl groups
TT_RS02675	COG1215	transferase activity, transferring glycosyl groups
TT_RS02685	COG0438	transferase activity, transferring glycosyl groups
TT_RS02690	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TT_RS02705	COG1024	Enoyl-CoA hydratase
TT_RS02705	COG1250	3-hydroxyacyl-CoA dehydrogenase
TT_RS02710	COG0183	Belongs to the thiolase family
TT_RS02715	COG1960	acyl-CoA dehydrogenase activity
TT_RS02720	COG0215	cysteine-tRNA ligase activity
TT_RS02725	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TT_RS02735	COG2738	Putative neutral zinc metallopeptidase
TT_RS02750	COG1196	nuclear chromosome segregation
TT_RS02765	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TT_RS02770	COG3153	acetyltransferase
TT_RS02770	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TT_RS02775	COG1268	BioY protein
TT_RS02785	COG0126	phosphoglycerate kinase activity
TT_RS02790	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TT_RS02795	COG0824	Thioesterase
TT_RS02805	COG0557	exoribonuclease II activity
TT_RS02810	COG1355	regulation of microtubule-based process
TT_RS02815	COG1353	crispr-associated protein
TT_RS02815	COG0617	tRNA 3'-terminal CCA addition
TT_RS02820	COG0237	dephospho-CoA kinase activity
TT_RS02835	COG0742	ribosomal rna small subunit methyltransferase
TT_RS02840	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TT_RS02845	COG0138	bifunctional purine biosynthesis protein purh
TT_RS02850	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TT_RS02860	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TT_RS02950	COG0149	triose-phosphate isomerase activity
TT_RS02955	COG3239	Fatty acid desaturase
TT_RS02960	COG1490	D-aminoacyl-tRNA deacylase activity
TT_RS02965	COG1307	EDD domain protein, DegV family
TT_RS02970	COG1307	EDD domain protein, DegV family
TT_RS02975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TT_RS02980	COG1510	regulation of RNA biosynthetic process
TT_RS02990	COG3769	mannosylglycerate metabolic process
TT_RS03000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TT_RS03010	COG1012	belongs to the aldehyde dehydrogenase family
TT_RS03015	COG2368	4-hydroxyphenylacetate
TT_RS03020	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TT_RS03050	COG2050	protein possibly involved in aromatic compounds catabolism
TT_RS03055	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TT_RS03065	COG1012	belongs to the aldehyde dehydrogenase family
TT_RS03065	COG2030	dehydratase
TT_RS03085	COG3396	Phenylacetate-CoA oxygenase
TT_RS03095	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TT_RS03105	COG0395	ABC-type sugar transport system, permease component
TT_RS03125	COG1980	fructose-bisphosphate aldolase activity
TT_RS03130	COG1733	regulation of RNA biosynthetic process
TT_RS03135	COG2193	ferroxidase activity
TT_RS03140	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TT_RS03145	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TT_RS03155	COG1331	Highly conserved protein containing a thioredoxin domain
TT_RS03160	COG0183	Belongs to the thiolase family
TT_RS03165	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TT_RS03170	COG0477	Major facilitator Superfamily
TT_RS03175	COG1846	Transcriptional regulator
TT_RS03185	COG5001	Diguanylate cyclase
TT_RS03185	COG5002	protein histidine kinase activity
TT_RS03210	COG0745	RESPONSE REGULATOR receiver
TT_RS03215	COG1012	belongs to the aldehyde dehydrogenase family
TT_RS03225	COG0248	Ppx GppA phosphatase
TT_RS03230	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TT_RS03260	COG0745	RESPONSE REGULATOR receiver
TT_RS03265	COG2205	protein histidine kinase activity
TT_RS03285	COG1136	(ABC) transporter
TT_RS03290	COG0577	efflux transmembrane transporter activity
TT_RS03290	COG1136	(ABC) transporter
TT_RS03295	COG1309	transcriptional regulator
TT_RS03380	COG0582	viral genome integration into host DNA
TT_RS03390	COG2897	thiosulfate sulfurtransferase activity
TT_RS03395	COG1760	l-serine dehydratase
TT_RS03400	COG2197	response regulator
TT_RS03405	COG0335	large ribosomal subunit rRNA binding
TT_RS03410	COG0336	Belongs to the RNA methyltransferase TrmD family
TT_RS03415	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TT_RS03420	COG1837	Belongs to the UPF0109 family
TT_RS03425	COG0228	four-way junction DNA binding
TT_RS03440	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TT_RS03445	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TT_RS03445	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TT_RS03450	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TT_RS03460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TT_RS03470	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TT_RS03475	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TT_RS03480	COG1702	phosphate starvation-inducible protein PhoH
TT_RS03490	COG4864	UPF0365 protein
TT_RS03500	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TT_RS03510	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TT_RS03510	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TT_RS03515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TT_RS03525	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TT_RS03530	COG1397	ADP-ribosylglycohydrolase
TT_RS03535	COG2239	Acts as a magnesium transporter
TT_RS03545	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TT_RS03545	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TT_RS03555	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TT_RS03555	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TT_RS03560	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TT_RS03565	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TT_RS03570	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TT_RS03575	COG0006	proline dipeptidase activity
TT_RS03585	COG0739	heme binding
TT_RS03595	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TT_RS03600	COG0254	rRNA binding
TT_RS03610	COG2001	Belongs to the MraZ family
TT_RS03615	COG0275	rRNA processing
TT_RS03625	COG0768	penicillin binding
TT_RS03630	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TT_RS03640	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TT_RS03645	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TT_RS03650	COG0772	Belongs to the SEDS family
TT_RS03655	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TT_RS03660	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TT_RS03665	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TT_RS03685	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TT_RS03695	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TT_RS03705	COG0159	tryptophan synthase activity
TT_RS03710	COG0133	tryptophan synthase activity
TT_RS03715	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TT_RS03720	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TT_RS03725	COG1744	ABC transporter substrate-binding protein PnrA-like
TT_RS03730	COG3845	ABC transporter
TT_RS03780	COG0438	transferase activity, transferring glycosyl groups
TT_RS03785	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TT_RS03795	COG0039	L-malate dehydrogenase activity
TT_RS03800	COG2819	hydrolase of the alpha beta superfamily
TT_RS03805	COG0861	Integral membrane protein TerC family
TT_RS03815	COG0247	lactate metabolic process
TT_RS03815	COG2181	nitrate reductase activity
TT_RS03825	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TT_RS03830	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TT_RS03835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TT_RS03845	COG0439	Biotin carboxylase
TT_RS03850	COG0511	ligase activity, forming carbon-carbon bonds
TT_RS03855	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TT_RS03875	COG0010	Belongs to the arginase family
TT_RS03890	COG1100	Small GTP-binding protein
TT_RS03900	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TT_RS03905	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TT_RS03915	COG2814	Major facilitator Superfamily
TT_RS03920	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TT_RS03925	COG1185	polyribonucleotide nucleotidyltransferase activity
TT_RS03930	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TT_RS03940	COG0745	RESPONSE REGULATOR receiver
TT_RS03945	COG5002	protein histidine kinase activity
TT_RS03950	COG1960	acyl-CoA dehydrogenase activity
TT_RS03955	COG2086	electron transfer activity
TT_RS03960	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TT_RS03970	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TT_RS03975	COG1573	uracil-dna glycosylase
TT_RS03980	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TT_RS03980	COG1796	DNA polymerase
TT_RS03990	COG2309	aminopeptidase activity
TT_RS04010	COG2873	o-acetylhomoserine
TT_RS04015	COG2358	TRAP transporter, solute receptor (TAXI family
TT_RS04025	COG1126	abc transporter atp-binding protein
TT_RS04035	COG1752	Esterase of the alpha-beta hydrolase superfamily
TT_RS04040	COG3311	Transcriptional regulator
TT_RS04050	COG0134	indole-3-glycerol-phosphate synthase activity
TT_RS04055	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TT_RS04065	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TT_RS04075	COG0525	valine-tRNA ligase activity
TT_RS04080	COG0765	amino acid transport
TT_RS04085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TT_RS04095	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TT_RS04100	COG0569	domain protein
TT_RS04105	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TT_RS04110	COG1426	Protein conserved in bacteria
TT_RS04115	COG2313	pseudouridylate synthase activity
TT_RS04125	COG3001	Fructosamine kinase
TT_RS04130	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TT_RS04140	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TT_RS04165	COG0012	GTP binding
TT_RS04170	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TT_RS04180	COG0424	maF-like protein
TT_RS04195	COG0768	penicillin binding
TT_RS04200	COG0850	regulation of cytokinetic process
TT_RS04205	COG2322	membrane
TT_RS04225	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TT_RS04230	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TT_RS04240	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TT_RS04255	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TT_RS04265	COG1131	(ABC) transporter
TT_RS04280	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TT_RS04295	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TT_RS04300	COG0440	acetolactate synthase activity
TT_RS04305	COG0028	Belongs to the TPP enzyme family
TT_RS04310	COG0492	ferredoxin-NADP+ reductase activity
TT_RS04315	COG4970	Tfp pilus assembly protein FimT
TT_RS04320	COG2165	general secretion pathway protein
TT_RS04325	COG4966	pilus assembly protein PilW
TT_RS04335	COG2165	general secretion pathway protein
TT_RS04350	COG4636	protein conserved in cyanobacteria
TT_RS04370	COG0180	Tryptophanyl-tRNA synthetase
TT_RS04375	COG0544	peptidyl-prolyl cis-trans isomerase activity
TT_RS04380	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TT_RS04385	COG0066	3-isopropylmalate dehydratase activity
TT_RS04390	COG0473	3-isopropylmalate dehydrogenase activity
TT_RS04405	COG0300	oxidoreductase activity
TT_RS04410	COG0129	dihydroxy-acid dehydratase activity
TT_RS04420	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TT_RS04425	COG1177	transmembrane transport
TT_RS04430	COG1176	ABC-type spermidine putrescine transport system, permease component I
TT_RS04435	COG3842	ATPase activity
TT_RS04440	COG0772	Belongs to the SEDS family
TT_RS04445	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TT_RS04450	COG2894	cell division
TT_RS04455	COG1733	regulation of RNA biosynthetic process
TT_RS04465	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TT_RS04465	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TT_RS04475	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TT_RS04480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TT_RS04485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TT_RS04490	COG0653	protein targeting
TT_RS04495	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TT_RS04515	COG0393	Putative heavy-metal-binding
TT_RS04520	COG1205	dead DEAH box helicase
TT_RS04520	COG1111	helicase
TT_RS04535	COG0358	DNA primase activity
TT_RS04545	COG1250	3-hydroxyacyl-CoA dehydrogenase
TT_RS04550	COG0697	spore germination
TT_RS04555	COG0612	Peptidase, M16
TT_RS04560	COG0612	Peptidase, M16
TT_RS04565	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TT_RS04580	COG1394	ATPase activity, coupled to movement of substances
TT_RS04585	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TT_RS04590	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TT_RS04595	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TT_RS04600	COG1527	subunit (C
TT_RS04605	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TT_RS04615	COG1269	ATP hydrolysis coupled proton transport
TT_RS04640	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TT_RS04650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TT_RS04665	COG0419	ATPase involved in DNA repair
TT_RS04670	COG0420	3'-5' exonuclease activity
TT_RS04690	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TT_RS04695	COG2884	Cell division ATP-binding protein ftsE
TT_RS04700	COG0793	Belongs to the peptidase S41A family
TT_RS04710	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TT_RS04710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TT_RS04715	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TT_RS04720	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TT_RS04730	COG1079	Belongs to the binding-protein-dependent transport system permease family
TT_RS04740	COG1129	ABC transporter
TT_RS04745	COG0746	molybdenum cofactor guanylyltransferase activity
TT_RS04760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TT_RS04780	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TT_RS04790	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TT_RS04800	COG1994	Peptidase M50
TT_RS04800	COG0517	IMP dehydrogenase activity
TT_RS04805	COG2358	TRAP transporter, solute receptor (TAXI family
TT_RS04815	COG2358	TRAP transporter, solute receptor (TAXI family
TT_RS04830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TT_RS04835	COG0788	formyltetrahydrofolate deformylase activity
TT_RS04840	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TT_RS04845	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TT_RS04850	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TT_RS04870	COG0737	Belongs to the 5'-nucleotidase family
TT_RS04875	COG0174	glutamine synthetase
TT_RS04885	COG0559	Belongs to the binding-protein-dependent transport system permease family
TT_RS04905	COG0747	negative chemotaxis
TT_RS04910	COG0601	transmembrane transport
TT_RS04915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TT_RS04925	COG0285	dihydrofolate synthase activity
TT_RS04930	COG1132	(ABC) transporter
TT_RS04935	COG1132	(ABC) transporter
TT_RS04940	COG0372	Belongs to the citrate synthase family
TT_RS04945	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TT_RS04950	COG1482	cell wall glycoprotein biosynthetic process
TT_RS04960	COG1515	deoxyribonuclease V activity
TT_RS04970	COG0776	regulation of translation
TT_RS04985	COG2197	response regulator
TT_RS04990	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TT_RS04995	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TT_RS05000	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TT_RS05005	COG1324	tolerance protein
TT_RS05020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TT_RS05040	COG2205	protein histidine kinase activity
TT_RS05050	COG0247	lactate metabolic process
TT_RS05055	COG1139	Iron-sulfur cluster binding protein
TT_RS05060	COG1556	Lactate utilization protein
TT_RS05070	COG1752	Esterase of the alpha-beta hydrolase superfamily
TT_RS05075	COG2815	serine threonine protein kinase
TT_RS05075	COG0515	serine threonine protein kinase
TT_RS05080	COG0860	N-Acetylmuramoyl-L-alanine amidase
TT_RS05090	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TT_RS05120	COG0473	3-isopropylmalate dehydrogenase activity
TT_RS05145	COG1450	Type ii and iii secretion system protein
TT_RS05150	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TT_RS05155	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TT_RS05160	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TT_RS05165	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TT_RS05165	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TT_RS05170	COG0736	holo-[acyl-carrier-protein] synthase activity
TT_RS05185	COG1160	GTP binding
TT_RS05190	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TT_RS05195	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TT_RS05195	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TT_RS05200	COG0083	homoserine kinase activity
TT_RS05215	COG0268	Binds directly to 16S ribosomal RNA
TT_RS05225	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TT_RS05230	COG0723	plastoquinol--plastocyanin reductase activity
TT_RS05240	COG3088	subunit of a heme lyase
TT_RS05240	COG4235	cytochrome complex assembly
TT_RS05245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TT_RS05250	COG1138	Cytochrome C-type biogenesis protein
TT_RS05255	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TT_RS05260	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TT_RS05265	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TT_RS05270	COG4133	protoheme IX ABC transporter activity
TT_RS05275	COG0785	Cytochrome C biogenesis protein
TT_RS05280	COG3258	Cytochrome c
TT_RS05290	COG0446	pyridine nucleotide-disulphide oxidoreductase
TT_RS05305	COG3258	Cytochrome c
TT_RS05310	COG2010	Cytochrome c
TT_RS05315	COG0737	Belongs to the 5'-nucleotidase family
TT_RS05320	COG2010	Cytochrome c
TT_RS05325	COG3258	Cytochrome c
TT_RS05345	COG2010	Cytochrome c
TT_RS05350	COG3842	ATPase activity
TT_RS05380	COG0318	PFAM AMP-dependent synthetase and ligase
TT_RS05385	COG3360	Dodecin
TT_RS05405	COG0813	purine-nucleoside phosphorylase activity
TT_RS05410	COG1136	(ABC) transporter
TT_RS05415	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TT_RS05420	COG2045	Belongs to the ComB family
TT_RS05430	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TT_RS05440	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TT_RS05450	COG0107	imidazoleglycerol-phosphate synthase activity
TT_RS05455	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TT_RS05455	COG0140	phosphoribosyl-ATP diphosphatase activity
TT_RS05460	COG1494	fructose-1,6-bisphosphatase
TT_RS05465	COG0686	Belongs to the AlaDH PNT family
TT_RS05470	COG0427	acetyl-CoA hydrolase
TT_RS05475	COG0084	hydrolase, TatD family'
TT_RS05480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TT_RS05490	COG0017	Asparaginyl-tRNA synthetase
TT_RS05500	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TT_RS05515	COG2009	succinate dehydrogenase
TT_RS05520	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TT_RS05550	COG0318	PFAM AMP-dependent synthetase and ligase
TT_RS05555	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TT_RS05560	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TT_RS05565	COG0504	CTP synthase activity
TT_RS05580	COG0069	glutamate synthase activity
TT_RS05580	COG0067	glutamate synthase
TT_RS05580	COG0070	glutamate synthase
TT_RS05585	COG0840	transmembrane signaling receptor activity
TT_RS05590	COG0305	Participates in initiation and elongation during chromosome replication
TT_RS05600	COG0475	glutathione-regulated potassium exporter activity
TT_RS05605	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TT_RS05605	COG0617	tRNA 3'-terminal CCA addition
TT_RS05605	COG0517	IMP dehydrogenase activity
TT_RS05620	COG0475	glutathione-regulated potassium exporter activity
TT_RS05625	COG0490	domain, Protein
TT_RS05645	COG3118	belongs to the thioredoxin family
TT_RS05675	COG0542	response to heat
TT_RS05680	COG0789	Transcriptional regulator
TT_RS05685	COG0484	heat shock protein binding
TT_RS05690	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TT_RS05695	COG0443	Heat shock 70 kDa protein
TT_RS05700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TT_RS05705	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TT_RS05710	COG0616	signal peptide processing
TT_RS05725	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
TT_RS05730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TT_RS05735	COG0714	Associated with various cellular activities
TT_RS05740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TT_RS05740	COG0574	Belongs to the PEP-utilizing enzyme family
TT_RS05745	COG1272	protein, Hemolysin III
TT_RS05755	COG5002	protein histidine kinase activity
TT_RS05755	COG3850	Histidine kinase
TT_RS05770	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TT_RS05785	COG1011	Hydrolase
TT_RS05805	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TT_RS05815	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TT_RS05825	COG0047	phosphoribosylformylglycinamidine synthase activity
TT_RS05835	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TT_RS05840	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TT_RS05845	COG0116	Belongs to the methyltransferase superfamily
TT_RS05860	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TT_RS05865	COG0497	DNA recombination
TT_RS05875	COG0604	alcohol dehydrogenase
TT_RS05895	COG0585	pseudouridine synthase activity
TT_RS05920	COG0557	exoribonuclease II activity
TT_RS05925	COG0473	3-isopropylmalate dehydrogenase activity
TT_RS05970	COG2050	protein possibly involved in aromatic compounds catabolism
TT_RS05980	COG0322	excinuclease ABC activity
TT_RS05985	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TT_RS05990	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TT_RS05995	COG1854	S-ribosylhomocysteine lyase activity
TT_RS06000	COG0519	Catalyzes the synthesis of GMP from XMP
TT_RS06000	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TT_RS06010	COG4274	PFAM GYD family protein
TT_RS06020	COG0328	RNA-DNA hybrid ribonuclease activity
TT_RS06025	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TT_RS06030	COG2095	MarC family integral membrane protein
TT_RS06035	COG1438	arginine binding
TT_RS06040	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TT_RS06045	COG1758	RNA polymerase activity
TT_RS06050	COG0194	GDP metabolic process
TT_RS06060	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TT_RS06065	COG2385	sporulation resulting in formation of a cellular spore
TT_RS06070	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
TT_RS06080	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TT_RS06120	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TT_RS06125	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TT_RS06130	COG1012	belongs to the aldehyde dehydrogenase family
TT_RS06135	COG0506	proline dehydrogenase activity
TT_RS06160	COG0156	8-amino-7-oxononanoate synthase activity
TT_RS06165	COG0827	DNA restriction-modification system
TT_RS06165	COG0732	type I restriction modification DNA specificity domain
TT_RS06175	COG0187	DNA topoisomerase II activity
TT_RS06180	COG1181	Belongs to the D-alanine--D-alanine ligase family
TT_RS06185	COG0193	aminoacyl-tRNA hydrolase activity
TT_RS06190	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TT_RS06215	COG2815	serine threonine protein kinase
TT_RS06215	COG0515	serine threonine protein kinase
TT_RS06220	COG0631	protein serine/threonine phosphatase activity
TT_RS06240	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TT_RS06245	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TT_RS06270	COG4946	Tricorn protease homolog
TT_RS06270	COG1506	peptidase
TT_RS06270	COG0823	Involved in the tonB-independent uptake of proteins
TT_RS06275	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TT_RS06280	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TT_RS06300	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TT_RS06305	COG1011	Hydrolase
TT_RS06330	COG0537	adenosine 5'-monophosphoramidase activity
TT_RS06335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TT_RS06340	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TT_RS06345	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TT_RS06350	COG0071	Belongs to the small heat shock protein (HSP20) family
TT_RS06355	COG2897	thiosulfate sulfurtransferase activity
TT_RS06360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TT_RS06370	COG1764	response to oxidative stress
TT_RS06395	COG3842	ATPase activity
TT_RS06400	COG0101	tRNA pseudouridine synthase activity
TT_RS06410	COG0601	transmembrane transport
TT_RS06425	COG0006	proline dipeptidase activity
TT_RS06430	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TT_RS06445	COG1166	arginine decarboxylase activity
TT_RS06450	COG3706	GGDEF domain
TT_RS06455	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TT_RS06460	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TT_RS06465	COG1611	Belongs to the LOG family
TT_RS06470	COG1193	negative regulation of DNA recombination
TT_RS06475	COG0366	Alpha amylase catalytic
TT_RS06510	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TT_RS06515	COG0142	geranyltranstransferase activity
TT_RS06525	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TT_RS06555	COG0203	ribosomal protein L17
TT_RS06560	COG0202	RNA polymerase activity
TT_RS06565	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TT_RS06570	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TT_RS06575	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TT_RS06585	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TT_RS06595	COG0563	adenylate kinase activity
TT_RS06600	COG0201	protein transport
TT_RS06625	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TT_RS06630	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TT_RS06635	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TT_RS06640	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TT_RS06660	COG0255	Belongs to the universal ribosomal protein uL29 family
TT_RS06665	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TT_RS06670	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TT_RS06680	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TT_RS06685	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TT_RS06690	COG0089	rRNA binding
TT_RS06695	COG0088	Forms part of the polypeptide exit tunnel
TT_RS06705	COG0051	transcription antitermination factor activity, RNA binding
TT_RS06710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TT_RS06715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TT_RS06720	COG0049	tRNA binding
TT_RS06735	COG0442	prolyl-tRNA aminoacylation
TT_RS06755	COG1115	amino acid carrier protein
TT_RS06775	COG1489	DNA binding
TT_RS06800	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TT_RS06820	COG0432	Pfam Uncharacterised protein family UPF0047
TT_RS06825	COG3253	May function as heme-dependent peroxidase
TT_RS06840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TT_RS06845	COG2217	Heavy metal translocating P-type atpase
TT_RS06865	COG0745	RESPONSE REGULATOR receiver
TT_RS06870	COG2205	protein histidine kinase activity
TT_RS06895	COG2226	methyltransferase
TT_RS06915	COG2132	Multicopper oxidase
TT_RS06930	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TT_RS06935	COG0822	iron-sulfur transferase activity
TT_RS06955	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TT_RS06965	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TT_RS06970	COG0284	orotidine-5'-phosphate decarboxylase activity
TT_RS06980	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TT_RS06990	COG0416	fatty acid biosynthetic process
TT_RS06995	COG3118	belongs to the thioredoxin family
TT_RS07000	COG1185	polyribonucleotide nucleotidyltransferase activity
TT_RS07005	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TT_RS07015	COG0438	transferase activity, transferring glycosyl groups
TT_RS07035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TT_RS07050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TT_RS07055	COG3706	GGDEF domain
TT_RS07105	COG0825	malonyl-CoA metabolic process
TT_RS07110	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TT_RS07145	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TT_RS07170	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TT_RS07175	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TT_RS07180	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TT_RS07185	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TT_RS07235	COG3328	transposase activity
TT_RS07255	COG0315	cyclic pyranopterin monophosphate synthase activity
TT_RS07260	COG2860	membrane
TT_RS07265	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TT_RS07280	COG0477	Major facilitator Superfamily
TT_RS07285	COG1694	Mazg nucleotide pyrophosphohydrolase
TT_RS07290	COG1803	Methylglyoxal synthase
TT_RS07300	COG0301	tRNA thio-modification
TT_RS07305	COG0154	amidase activity
TT_RS07310	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TT_RS07335	COG2154	pterin-4-alpha-carbinolamine dehydratase
TT_RS07340	COG1607	acyl-coa hydrolase
TT_RS07350	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TT_RS07355	COG4149	molybdate abc transporter
TT_RS07360	COG1840	ABC-type Fe3 transport system, periplasmic component
TT_RS07375	COG0235	Class ii aldolase
TT_RS07380	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TT_RS07385	COG0085	RNA polymerase activity
TT_RS07395	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TT_RS07400	COG1077	Cell shape determining protein MreB Mrl
TT_RS07405	COG1418	mRNA catabolic process
TT_RS07405	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TT_RS07410	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TT_RS07415	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TT_RS07420	COG1058	Belongs to the CinA family
TT_RS07420	COG1546	Belongs to the CinA family
TT_RS07425	COG0354	folic acid binding
TT_RS07445	COG4948	Mandelate Racemase Muconate Lactonizing
TT_RS07460	COG1175	transmembrane transport
TT_RS07470	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TT_RS07480	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TT_RS07490	COG1136	(ABC) transporter
TT_RS07490	COG0577	efflux transmembrane transporter activity
TT_RS07495	COG4181	ATPase activity
TT_RS07500	COG0446	pyridine nucleotide-disulphide oxidoreductase
TT_RS07515	COG0396	ATPase activity
TT_RS07520	COG0719	Fe-S assembly protein
TT_RS07525	COG0719	Fe-S assembly protein
TT_RS07530	COG2146	nitrite reductase [NAD(P)H] activity
TT_RS07540	COG0512	Glutamine amidotransferase of anthranilate synthase
TT_RS07545	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TT_RS07580	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TT_RS07585	COG2226	methyltransferase
TT_RS07590	COG4603	Belongs to the binding-protein-dependent transport system permease family
TT_RS07595	COG1079	Belongs to the binding-protein-dependent transport system permease family
TT_RS07610	COG1774	PSP1 C-terminal conserved region
TT_RS07615	COG0470	DNA polymerase III
TT_RS07650	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TT_RS07655	COG0302	gtp cyclohydrolase
TT_RS07680	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TT_RS07690	COG0395	ABC-type sugar transport system, permease component
TT_RS07695	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TT_RS07700	COG1131	(ABC) transporter
TT_RS07720	COG0556	nucleotide-excision repair
TT_RS07725	COG0497	DNA recombination
TT_RS07730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TT_RS07740	COG0445	tRNA wobble uridine modification
TT_RS07765	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TT_RS07765	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TT_RS07770	COG1543	Belongs to the glycosyl hydrolase 57 family
TT_RS07775	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TT_RS07780	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TT_RS07785	COG0189	ligase activity
TT_RS07800	COG0066	3-isopropylmalate dehydratase activity
TT_RS07805	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TT_RS07820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TT_RS07825	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TT_RS07830	COG1960	acyl-CoA dehydrogenase activity
TT_RS07835	COG0163	prenyltransferase activity
TT_RS07875	COG1668	transmembrane transport
TT_RS07880	COG4555	ABC transporter
TT_RS07890	COG2096	Adenosyltransferase
TT_RS07905	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TT_RS07910	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TT_RS07925	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TT_RS07930	COG0723	plastoquinol--plastocyanin reductase activity
TT_RS07955	COG1653	transport
TT_RS07960	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TT_RS07965	COG1960	acyl-CoA dehydrogenase activity
TT_RS07975	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TT_RS07995	COG0393	Putative heavy-metal-binding
TT_RS08005	COG3956	TIGRFAM MazG family protein
TT_RS08015	COG0693	protein deglycase activity
TT_RS08020	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TT_RS08030	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TT_RS08035	COG1937	Protein conserved in bacteria
TT_RS08045	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TT_RS08045	COG0674	pyruvate-flavodoxin oxidoreductase activity
TT_RS08050	COG1013	pyruvate-flavodoxin oxidoreductase activity
TT_RS08055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TT_RS08060	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TT_RS08065	COG0072	phenylalanine-tRNA ligase activity
TT_RS08065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TT_RS08075	COG0205	6-phosphofructokinase activity
TT_RS08080	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TT_RS08090	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TT_RS08105	COG2333	competence protein COMEC
TT_RS08105	COG0658	competence protein
TT_RS08110	COG1475	DNA binding
TT_RS08115	COG1192	Involved in chromosome partitioning
TT_RS08120	COG0357	Ribosomal RNA small subunit methyltransferase G
TT_RS08125	COG0445	tRNA wobble uridine modification
TT_RS08130	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TT_RS08135	COG0592	DNA-directed DNA polymerase activity
TT_RS08140	COG0148	phosphopyruvate hydratase activity
TT_RS08145	COG0469	pyruvate kinase activity
TT_RS08155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TT_RS08160	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TT_RS08170	COG1842	Phage shock protein A
TT_RS08200	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TT_RS08205	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TT_RS08215	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TT_RS08220	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TT_RS08225	COG1496	oxidoreductase activity
TT_RS08230	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TT_RS08235	COG1278	Cold shock
TT_RS08240	COG1653	transport
TT_RS08255	COG0033	Phosphoglucomutase
TT_RS08280	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TT_RS08280	COG0517	IMP dehydrogenase activity
TT_RS08285	COG1950	PFAM Membrane protein of
TT_RS08290	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TT_RS08300	COG0181	hydroxymethylbilane synthase activity
TT_RS08310	COG0285	dihydrofolate synthase activity
TT_RS08315	COG0436	Aminotransferase
TT_RS08320	COG0521	Mo-molybdopterin cofactor biosynthetic process
TT_RS08345	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TT_RS08350	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TT_RS08355	COG1993	acr, cog1993
TT_RS08360	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TT_RS08370	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TT_RS08380	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TT_RS08385	COG1335	isochorismatase
TT_RS08390	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TT_RS08405	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TT_RS08410	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TT_RS08430	COG1660	Displays ATPase and GTPase activities
TT_RS08435	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TT_RS08480	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TT_RS08480	COG1845	cytochrome c oxidase, subunit III
TT_RS08485	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TT_RS08485	COG2010	Cytochrome c
TT_RS08490	COG0109	protoheme IX farnesyltransferase activity
TT_RS08490	COG1612	heme a metabolic process
TT_RS08505	COG0343	queuine tRNA-ribosyltransferase activity
TT_RS08510	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TT_RS08515	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TT_RS08570	COG1940	carbohydrate kinase activity
TT_RS08580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TT_RS08585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TT_RS08590	COG0589	response to stress
TT_RS08595	COG1611	Belongs to the LOG family
TT_RS08605	COG1011	Hydrolase
TT_RS08610	COG0632	four-way junction helicase activity
TT_RS08615	COG1024	Enoyl-CoA hydratase
TT_RS08625	COG0508	dehydrogenase complex catalyzes the overall conversion of
TT_RS08635	COG0137	argininosuccinate synthase activity
TT_RS08640	COG0165	Argininosuccinate lyase
TT_RS08660	COG0505	Belongs to the CarA family
TT_RS08665	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TT_RS08675	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TT_RS08680	COG0166	Belongs to the GPI family
TT_RS08690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TT_RS08695	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TT_RS08700	COG0459	protein refolding
TT_RS08705	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TT_RS08710	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TT_RS08720	COG0778	Nitroreductase
TT_RS08725	COG1388	LysM domain
TT_RS08725	COG0791	NLP P60 protein
TT_RS08735	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TT_RS08745	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TT_RS08750	COG0581	inorganic phosphate transmembrane transporter activity
TT_RS08755	COG0573	inorganic phosphate transmembrane transporter activity
TT_RS08760	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TT_RS08765	COG0482	sulfurtransferase activity
TT_RS08775	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TT_RS08780	COG0735	belongs to the Fur family
TT_RS08795	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TT_RS08820	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TT_RS08825	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TT_RS08830	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TT_RS08835	COG0250	Participates in transcription elongation, termination and antitermination
TT_RS08860	COG0629	single-stranded DNA binding
TT_RS08865	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TT_RS08870	COG0359	binds to the 23S rRNA
TT_RS08880	COG0300	oxidoreductase activity
TT_RS08885	COG0321	lipoyl(octanoyl) transferase activity
TT_RS08890	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TT_RS08920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TT_RS08930	COG1598	PFAM Uncharacterised protein family UPF0150
TT_RS08935	COG0022	dehydrogenase e1 component
TT_RS08940	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TT_RS08945	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TT_RS08970	COG2226	methyltransferase
TT_RS08975	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TT_RS08985	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TT_RS08990	COG1187	pseudouridine synthase activity
TT_RS09000	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TT_RS09005	COG0686	Belongs to the AlaDH PNT family
TT_RS09015	COG1461	Dihydroxyacetone kinase
TT_RS09025	COG3583	domain protein
TT_RS09025	COG3584	3D domain protein
TT_RS09030	COG4591	ABC-type transport system involved in lipoprotein release permease component
TT_RS09035	COG0222	ribosome binding
TT_RS09040	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TT_RS09050	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TT_RS09065	COG0697	spore germination
TT_RS09075	COG3177	Filamentation induced by cAMP protein fic
TT_RS09085	COG0243	molybdopterin cofactor binding
TT_RS09090	COG2272	Belongs to the type-B carboxylesterase lipase family
TT_RS09095	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TT_RS09105	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TT_RS09120	COG0477	Major facilitator Superfamily
TT_RS09135	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TT_RS09145	COG0105	UTP biosynthetic process
TT_RS09150	COG0631	protein serine/threonine phosphatase activity
TT_RS09155	COG0583	DNA-binding transcription factor activity
TT_RS09160	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
TT_RS09165	COG0508	dehydrogenase complex catalyzes the overall conversion of
TT_RS09200	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TT_RS09210	COG1278	Cold shock
TT_RS09215	COG0484	heat shock protein binding
TT_RS09220	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TT_RS09225	COG1968	undecaprenyl-diphosphatase activity
TT_RS09230	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TT_RS09235	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TT_RS09250	COG1309	transcriptional regulator
TT_RS09255	COG4242	Belongs to the peptidase S51 family
TT_RS09270	COG0802	atpase or kinase
TT_RS09280	COG0539	negative regulation of cytoplasmic translation
TT_RS09285	COG0495	leucyl-tRNA aminoacylation
TT_RS09305	COG1902	pentaerythritol trinitrate reductase activity
TT_RS09330	COG2414	aldehyde ferredoxin oxidoreductase
TT_RS09340	COG2165	general secretion pathway protein
TT_RS09350	COG2165	general secretion pathway protein
TT_RS09355	COG2165	general secretion pathway protein
TT_RS09385	COG1459	type II secretion system
TT_RS09395	COG1187	pseudouridine synthase activity
TT_RS09405	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TT_RS09410	COG0745	RESPONSE REGULATOR receiver
TT_RS09415	COG4191	Histidine kinase
TT_RS09420	COG0704	Plays a role in the regulation of phosphate uptake
TT_RS09425	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TT_RS09435	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TT_RS09445	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TT_RS09445	COG0515	serine threonine protein kinase
TT_RS09470	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TT_RS09475	COG1028	Short-chain dehydrogenase reductase Sdr
TT_RS09490	COG0717	Belongs to the dCTP deaminase family
TT_RS09495	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TT_RS09500	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TT_RS09505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TT_RS09525	COG0583	DNA-binding transcription factor activity
TT_RS09530	COG3546	catalase activity
TT_RS09535	COG0758	DNA mediated transformation
TT_RS09535	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TT_RS09540	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TT_RS09555	COG0582	viral genome integration into host DNA
TT_RS09595	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TT_RS09605	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TT_RS09610	COG0442	prolyl-tRNA aminoacylation
TT_RS09615	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TT_RS09635	COG0303	'Molybdopterin
TT_RS09640	COG0513	Belongs to the DEAD box helicase family
TT_RS09660	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TT_RS09680	COG2070	2-Nitropropane dioxygenase
TT_RS09695	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TT_RS09700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TT_RS09705	COG0018	arginyl-trna synthetase
TT_RS09710	COG1007	ATP synthesis coupled electron transport
TT_RS09715	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TT_RS09720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TT_RS09725	COG0713	ATP synthesis coupled electron transport
TT_RS09730	COG0839	Belongs to the complex I subunit 6 family
TT_RS09735	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TT_RS09740	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TT_RS09745	COG1034	ATP synthesis coupled electron transport
TT_RS09750	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TT_RS09755	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TT_RS09760	COG0649	NAD binding
TT_RS09765	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TT_RS09770	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TT_RS09775	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TT_RS09780	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TT_RS09790	COG4712	double-strand break repair protein
TT_RS09805	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TT_RS09820	COG0135	phosphoribosylanthranilate isomerase activity
TT_RS09830	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TT_RS09840	COG2720	vancomycin resistance protein
TT_RS09845	COG1126	abc transporter atp-binding protein
TT_RS09875	COG0277	FAD linked oxidase domain protein
TT_RS09885	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TT_RS09895	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TT_RS09910	COG0314	molybdopterin synthase activity
TT_RS09915	COG1420	regulation of RNA biosynthetic process
TT_RS09920	COG0347	Belongs to the P(II) protein family
TT_RS09925	COG0004	ammonium transporteR
TT_RS09935	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TT_RS09945	COG0123	including yeast histone deacetylase and acetoin utilization protein
TT_RS09960	COG1597	lipid kinase activity
TT_RS09975	COG0436	Aminotransferase
TT_RS09985	COG0569	domain protein
TT_RS09985	COG0475	glutathione-regulated potassium exporter activity
TT_RS09995	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TT_RS10005	COG0277	FAD linked oxidase domain protein
TT_RS10020	COG0667	Aldo Keto reductase
TT_RS10050	COG1067	ATP-dependent peptidase activity
TT_RS10055	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TT_RS10065	COG0745	RESPONSE REGULATOR receiver
TT_RS10070	COG2105	PFAM AIG2 family protein
TT_RS10075	COG0297	glycogen (starch) synthase activity
TT_RS10085	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TT_RS10090	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TT_RS10105	COG0142	geranyltranstransferase activity
TT_RS10115	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TT_RS10165	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TT_RS10170	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TT_RS10190	COG0395	ABC-type sugar transport system, permease component
TT_RS10235	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TT_RS10440	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TT_RS10495	COG2890	protein-(glutamine-N5) methyltransferase activity
TT_RS10595	COG0747	negative chemotaxis
TT_RS10750	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA