locus-tag	class	description
JMH49_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JMH49_RS00010	COG0592	DNA-directed DNA polymerase activity
JMH49_RS00015	COG0148	phosphopyruvate hydratase activity
JMH49_RS00020	COG0469	pyruvate kinase activity
JMH49_RS00030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JMH49_RS00035	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JMH49_RS00045	COG1842	Phage shock protein A
JMH49_RS00065	COG0406	alpha-ribazole phosphatase activity
JMH49_RS00070	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JMH49_RS00075	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JMH49_RS00085	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JMH49_RS00090	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
JMH49_RS00095	COG1496	oxidoreductase activity
JMH49_RS00100	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
JMH49_RS00105	COG1278	Cold shock
JMH49_RS00125	COG0033	Phosphoglucomutase
JMH49_RS00150	COG0517	IMP dehydrogenase activity
JMH49_RS00150	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
JMH49_RS00155	COG1950	PFAM Membrane protein of
JMH49_RS00160	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JMH49_RS00170	COG0181	hydroxymethylbilane synthase activity
JMH49_RS00180	COG0285	dihydrofolate synthase activity
JMH49_RS00185	COG0436	Aminotransferase
JMH49_RS00190	COG0521	Mo-molybdopterin cofactor biosynthetic process
JMH49_RS00215	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JMH49_RS00220	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JMH49_RS00225	COG1993	acr, cog1993
JMH49_RS00230	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
JMH49_RS00245	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JMH49_RS00255	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
JMH49_RS00260	COG1335	isochorismatase
JMH49_RS00265	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
JMH49_RS00280	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
JMH49_RS00285	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
JMH49_RS00305	COG1660	Displays ATPase and GTPase activities
JMH49_RS00310	COG0391	Required for morphogenesis under gluconeogenic growth conditions
JMH49_RS00355	COG1845	cytochrome c oxidase, subunit III
JMH49_RS00355	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JMH49_RS00360	COG2010	Cytochrome c
JMH49_RS00360	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JMH49_RS00365	COG0109	protoheme IX farnesyltransferase activity
JMH49_RS00365	COG1612	heme a metabolic process
JMH49_RS00380	COG0343	queuine tRNA-ribosyltransferase activity
JMH49_RS00385	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JMH49_RS00390	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JMH49_RS00410	COG1940	carbohydrate kinase activity
JMH49_RS00420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JMH49_RS00425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JMH49_RS00435	COG1611	Belongs to the LOG family
JMH49_RS00445	COG1011	Hydrolase
JMH49_RS00450	COG0632	four-way junction helicase activity
JMH49_RS00455	COG1024	Enoyl-CoA hydratase
JMH49_RS00475	COG1404	Belongs to the peptidase S8 family
JMH49_RS00490	COG0137	argininosuccinate synthase activity
JMH49_RS00495	COG0165	Argininosuccinate lyase
JMH49_RS00515	COG0505	Belongs to the CarA family
JMH49_RS00525	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
JMH49_RS00530	COG0166	Belongs to the GPI family
JMH49_RS00540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JMH49_RS00545	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
JMH49_RS00550	COG0459	protein refolding
JMH49_RS00555	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
JMH49_RS00560	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
JMH49_RS00570	COG0778	Nitroreductase
JMH49_RS00575	COG0791	NLP P60 protein
JMH49_RS00575	COG1388	LysM domain
JMH49_RS00585	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JMH49_RS00590	COG2814	Major facilitator Superfamily
JMH49_RS00595	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JMH49_RS00600	COG0581	inorganic phosphate transmembrane transporter activity
JMH49_RS00605	COG0573	inorganic phosphate transmembrane transporter activity
JMH49_RS00610	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JMH49_RS00615	COG0482	sulfurtransferase activity
JMH49_RS00625	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JMH49_RS00630	COG0735	belongs to the Fur family
JMH49_RS00675	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JMH49_RS00680	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JMH49_RS00685	COG0250	Participates in transcription elongation, termination and antitermination
JMH49_RS00695	COG0081	regulation of translation
JMH49_RS00710	COG0629	single-stranded DNA binding
JMH49_RS00715	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JMH49_RS00720	COG0359	binds to the 23S rRNA
JMH49_RS00725	COG0300	oxidoreductase activity
JMH49_RS00730	COG0321	lipoyl(octanoyl) transferase activity
JMH49_RS00735	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JMH49_RS00765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JMH49_RS00780	COG1598	PFAM Uncharacterised protein family UPF0150
JMH49_RS00785	COG0022	dehydrogenase e1 component
JMH49_RS00790	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JMH49_RS00795	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
JMH49_RS00820	COG2226	methyltransferase
JMH49_RS00825	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JMH49_RS00835	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
JMH49_RS00840	COG1187	pseudouridine synthase activity
JMH49_RS00850	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JMH49_RS00855	COG0686	Belongs to the AlaDH PNT family
JMH49_RS00865	COG1461	Dihydroxyacetone kinase
JMH49_RS00875	COG3583	domain protein
JMH49_RS00875	COG3584	3D domain protein
JMH49_RS00880	COG4591	ABC-type transport system involved in lipoprotein release permease component
JMH49_RS00885	COG0222	ribosome binding
JMH49_RS00890	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JMH49_RS00900	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
JMH49_RS00915	COG0697	spore germination
JMH49_RS00925	COG3177	Filamentation induced by cAMP protein fic
JMH49_RS00935	COG0243	molybdopterin cofactor binding
JMH49_RS00940	COG2272	Belongs to the type-B carboxylesterase lipase family
JMH49_RS00955	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
JMH49_RS00970	COG0477	Major facilitator Superfamily
JMH49_RS00985	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
JMH49_RS00995	COG0105	UTP biosynthetic process
JMH49_RS01000	COG0631	protein serine/threonine phosphatase activity
JMH49_RS01005	COG0583	DNA-binding transcription factor activity
JMH49_RS01015	COG0508	dehydrogenase complex catalyzes the overall conversion of
JMH49_RS01050	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
JMH49_RS01060	COG1278	Cold shock
JMH49_RS01065	COG0484	heat shock protein binding
JMH49_RS01070	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JMH49_RS01075	COG1968	undecaprenyl-diphosphatase activity
JMH49_RS01080	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JMH49_RS01085	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JMH49_RS01100	COG1309	transcriptional regulator
JMH49_RS01105	COG4242	Belongs to the peptidase S51 family
JMH49_RS01120	COG0802	atpase or kinase
JMH49_RS01130	COG0539	negative regulation of cytoplasmic translation
JMH49_RS01135	COG0495	leucyl-tRNA aminoacylation
JMH49_RS01155	COG1902	pentaerythritol trinitrate reductase activity
JMH49_RS01180	COG2414	aldehyde ferredoxin oxidoreductase
JMH49_RS01195	COG1187	pseudouridine synthase activity
JMH49_RS01205	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JMH49_RS01210	COG0745	RESPONSE REGULATOR receiver
JMH49_RS01215	COG4191	Histidine kinase
JMH49_RS01220	COG0704	Plays a role in the regulation of phosphate uptake
JMH49_RS01235	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JMH49_RS01245	COG0515	serine threonine protein kinase
JMH49_RS01245	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JMH49_RS01270	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JMH49_RS01275	COG1028	Short-chain dehydrogenase reductase Sdr
JMH49_RS01290	COG0717	Belongs to the dCTP deaminase family
JMH49_RS01295	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
JMH49_RS01300	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JMH49_RS01305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JMH49_RS01315	COG0583	DNA-binding transcription factor activity
JMH49_RS01320	COG3546	catalase activity
JMH49_RS01325	COG0758	DNA mediated transformation
JMH49_RS01325	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JMH49_RS01330	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JMH49_RS01345	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
JMH49_RS01355	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
JMH49_RS01360	COG0442	prolyl-tRNA aminoacylation
JMH49_RS01395	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JMH49_RS01415	COG0303	'Molybdopterin
JMH49_RS01420	COG0513	Belongs to the DEAD box helicase family
JMH49_RS01440	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JMH49_RS01460	COG2070	2-Nitropropane dioxygenase
JMH49_RS01475	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JMH49_RS01480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JMH49_RS01485	COG0018	arginyl-trna synthetase
JMH49_RS01490	COG1007	ATP synthesis coupled electron transport
JMH49_RS01495	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JMH49_RS01500	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JMH49_RS01505	COG0713	ATP synthesis coupled electron transport
JMH49_RS01510	COG0839	Belongs to the complex I subunit 6 family
JMH49_RS01515	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JMH49_RS01520	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
JMH49_RS01525	COG1034	ATP synthesis coupled electron transport
JMH49_RS01530	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
JMH49_RS01535	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
JMH49_RS01540	COG0649	NAD binding
JMH49_RS01545	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JMH49_RS01550	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JMH49_RS01555	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JMH49_RS01560	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JMH49_RS01570	COG4712	double-strand break repair protein
JMH49_RS01585	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
JMH49_RS01600	COG0135	phosphoribosylanthranilate isomerase activity
JMH49_RS01610	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JMH49_RS01620	COG2720	vancomycin resistance protein
JMH49_RS01625	COG1126	abc transporter atp-binding protein
JMH49_RS01655	COG0277	FAD linked oxidase domain protein
JMH49_RS01665	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JMH49_RS01670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JMH49_RS01685	COG0314	molybdopterin synthase activity
JMH49_RS01690	COG1420	regulation of RNA biosynthetic process
JMH49_RS01695	COG0347	Belongs to the P(II) protein family
JMH49_RS01700	COG0004	ammonium transporteR
JMH49_RS01710	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
JMH49_RS01720	COG0123	including yeast histone deacetylase and acetoin utilization protein
JMH49_RS01735	COG1597	lipid kinase activity
JMH49_RS01750	COG0436	Aminotransferase
JMH49_RS01760	COG0475	glutathione-regulated potassium exporter activity
JMH49_RS01760	COG0569	domain protein
JMH49_RS01770	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JMH49_RS01780	COG0277	FAD linked oxidase domain protein
JMH49_RS01820	COG2002	toxin-antitoxin pair type II binding
JMH49_RS01845	COG0667	Aldo Keto reductase
JMH49_RS01865	COG1067	ATP-dependent peptidase activity
JMH49_RS01870	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JMH49_RS01885	COG2105	PFAM AIG2 family protein
JMH49_RS01890	COG0297	glycogen (starch) synthase activity
JMH49_RS01900	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JMH49_RS01905	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JMH49_RS01920	COG0142	geranyltranstransferase activity
JMH49_RS01930	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JMH49_RS01950	COG1028	Short-chain dehydrogenase reductase Sdr
JMH49_RS01955	COG0492	ferredoxin-NADP+ reductase activity
JMH49_RS01965	COG0792	nuclease activity
JMH49_RS01970	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
JMH49_RS01985	COG1175	transmembrane transport
JMH49_RS01990	COG0395	ABC-type sugar transport system, permease component
JMH49_RS02020	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JMH49_RS02025	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JMH49_RS02030	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JMH49_RS02035	COG0805	protein transport
JMH49_RS02040	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
JMH49_RS02040	COG1605	Chorismate mutase
JMH49_RS02095	COG1063	alcohol dehydrogenase
JMH49_RS02125	COG2255	four-way junction helicase activity
JMH49_RS02130	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JMH49_RS02135	COG0564	pseudouridine synthase activity
JMH49_RS02165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JMH49_RS02170	COG0232	Belongs to the dGTPase family. Type 2 subfamily
JMH49_RS02175	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JMH49_RS02180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JMH49_RS02190	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
JMH49_RS02195	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JMH49_RS02200	COG0333	Belongs to the bacterial ribosomal protein bL32 family
JMH49_RS02235	COG0778	Nitroreductase
JMH49_RS02250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JMH49_RS02255	COG0131	Imidazoleglycerol-phosphate dehydratase
JMH49_RS02260	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JMH49_RS02265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JMH49_RS02270	COG0517	IMP dehydrogenase activity
JMH49_RS02270	COG0516	GMP reductase activity
JMH49_RS02285	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
JMH49_RS02300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JMH49_RS02310	COG2890	protein-(glutamine-N5) methyltransferase activity
JMH49_RS02320	COG0706	membrane insertase activity
JMH49_RS02325	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JMH49_RS02330	COG0594	ribonuclease P activity
JMH49_RS02335	COG0230	Belongs to the bacterial ribosomal protein bL34 family
JMH49_RS02345	COG1022	Amp-dependent synthetase and ligase
JMH49_RS02370	COG1121	(ABC) transporter
JMH49_RS02375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JMH49_RS02380	COG1959	2 iron, 2 sulfur cluster binding
JMH49_RS02385	COG1104	cysteine desulfurase activity
JMH49_RS02390	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JMH49_RS02395	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
JMH49_RS02410	COG1028	Short-chain dehydrogenase reductase Sdr
JMH49_RS02435	COG0492	ferredoxin-NADP+ reductase activity
JMH49_RS02440	COG0604	alcohol dehydrogenase
JMH49_RS02440	COG3321	synthase
JMH49_RS02440	COG1028	Short-chain dehydrogenase reductase Sdr
JMH49_RS02445	COG0747	negative chemotaxis
JMH49_RS02450	COG0601	transmembrane transport
JMH49_RS02455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JMH49_RS02470	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
JMH49_RS02470	COG0617	tRNA 3'-terminal CCA addition
JMH49_RS02470	COG0517	IMP dehydrogenase activity
JMH49_RS02475	COG0123	including yeast histone deacetylase and acetoin utilization protein
JMH49_RS02480	COG2104	thiamine diphosphate biosynthetic process
JMH49_RS02485	COG0037	tRNA processing
JMH49_RS02510	COG0366	Alpha amylase catalytic
JMH49_RS02515	COG2226	methyltransferase
JMH49_RS02520	COG2226	methyltransferase
JMH49_RS02530	COG0815	Transfers the fatty acyl group on membrane lipoproteins
JMH49_RS02540	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JMH49_RS02545	COG3744	PilT protein domain protein
JMH49_RS02555	COG0460	homoserine dehydrogenase
JMH49_RS02565	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JMH49_RS02605	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JMH49_RS02635	COG0247	lactate metabolic process
JMH49_RS02640	COG0277	FAD linked oxidase domain protein
JMH49_RS02645	COG0277	FAD linked oxidase domain protein
JMH49_RS02650	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
JMH49_RS02655	COG1414	Transcriptional regulator
JMH49_RS02660	COG0789	Transcriptional regulator
JMH49_RS02670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JMH49_RS02675	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
JMH49_RS02710	COG0861	Integral membrane protein TerC family
JMH49_RS02715	COG2151	metal-sulfur cluster biosynthetic enzyme
JMH49_RS02720	COG0281	malic enzyme
JMH49_RS02735	COG0404	The glycine cleavage system catalyzes the degradation of glycine
JMH49_RS02740	COG0509	glycine decarboxylation via glycine cleavage system
JMH49_RS02745	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JMH49_RS02750	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JMH49_RS02755	COG0196	riboflavin kinase activity
JMH49_RS02785	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JMH49_RS02790	COG2813	Specifically methylates the guanine in position
JMH49_RS02825	COG4956	integral membrane protein (PIN domain superfamily)
JMH49_RS02830	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JMH49_RS02835	COG0542	response to heat
JMH49_RS02840	COG0423	glycine-tRNA ligase activity
JMH49_RS02850	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JMH49_RS02870	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JMH49_RS02870	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JMH49_RS02880	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JMH49_RS02890	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JMH49_RS02900	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
JMH49_RS02905	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JMH49_RS02910	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
JMH49_RS02915	COG0114	fumarate hydratase activity
JMH49_RS02920	COG0183	Belongs to the thiolase family
JMH49_RS02935	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
JMH49_RS02940	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JMH49_RS02955	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JMH49_RS02960	COG1254	Belongs to the acylphosphatase family
JMH49_RS02970	COG1063	alcohol dehydrogenase
JMH49_RS02975	COG2133	pyrroloquinoline quinone binding
JMH49_RS02985	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JMH49_RS02990	COG0154	amidase activity
JMH49_RS03015	COG0572	uridine kinase
JMH49_RS03020	COG3842	ATPase activity
JMH49_RS03035	COG4475	Protein of unknown function (DUF436)
JMH49_RS03090	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
JMH49_RS03095	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JMH49_RS03100	COG0803	Belongs to the bacterial solute-binding protein 9 family
JMH49_RS03115	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
JMH49_RS03120	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
JMH49_RS03125	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JMH49_RS03130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JMH49_RS03140	COG0318	PFAM AMP-dependent synthetase and ligase
JMH49_RS03155	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
JMH49_RS03160	COG1293	RNA-binding protein homologous to eukaryotic snRNP
JMH49_RS03165	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
JMH49_RS03175	COG3870	Protein conserved in bacteria
JMH49_RS03180	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JMH49_RS03200	COG0544	peptidyl-prolyl cis-trans isomerase activity
JMH49_RS03205	COG0740	serine-type endopeptidase activity
JMH49_RS03210	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JMH49_RS03215	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
JMH49_RS03220	COG1410	methionine synthase
JMH49_RS03220	COG0646	methionine synthase
JMH49_RS03230	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JMH49_RS03255	COG1692	metallophosphoesterase
JMH49_RS03260	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
JMH49_RS03265	COG1970	mechanosensitive ion channel activity
JMH49_RS03350	COG2189	Belongs to the N(4) N(6)-methyltransferase family
JMH49_RS03360	COG0582	viral genome integration into host DNA
JMH49_RS03380	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JMH49_RS03390	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
JMH49_RS03395	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
JMH49_RS03450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JMH49_RS03495	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JMH49_RS03515	COG0489	protein tyrosine kinase activity
JMH49_RS03525	COG2264	protein methyltransferase activity
JMH49_RS03530	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JMH49_RS03565	COG0574	Belongs to the PEP-utilizing enzyme family
JMH49_RS03565	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JMH49_RS03575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JMH49_RS03580	COG2046	Belongs to the sulfate adenylyltransferase family
JMH49_RS03590	COG0730	response to heat
JMH49_RS03595	COG0175	sulfate reduction
JMH49_RS03600	COG1648	precorrin-2 dehydrogenase activity
JMH49_RS03600	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JMH49_RS03605	COG1587	Uroporphyrinogen-III synthase
JMH49_RS03610	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JMH49_RS03620	COG0352	thiamine-phosphate diphosphorylase activity
JMH49_RS03625	COG2104	thiamine diphosphate biosynthetic process
JMH49_RS03630	COG2022	thiamine diphosphate biosynthetic process
JMH49_RS03635	COG2022	thiamine diphosphate biosynthetic process
JMH49_RS03635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JMH49_RS03640	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
JMH49_RS03645	COG0477	Major facilitator Superfamily
JMH49_RS03650	COG0352	thiamine-phosphate diphosphorylase activity
JMH49_RS03650	COG0351	phosphomethylpyrimidine kinase
JMH49_RS03680	COG1175	transmembrane transport
JMH49_RS03690	COG1940	carbohydrate kinase activity
JMH49_RS03695	COG0183	Belongs to the thiolase family
JMH49_RS03710	COG1028	Short-chain dehydrogenase reductase Sdr
JMH49_RS03740	COG2030	dehydratase
JMH49_RS03750	COG0596	Alpha beta hydrolase
JMH49_RS03755	COG0318	PFAM AMP-dependent synthetase and ligase
JMH49_RS03770	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JMH49_RS03770	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JMH49_RS03780	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JMH49_RS03790	COG0195	Participates in both transcription termination and antitermination
JMH49_RS03795	COG0779	Required for maturation of 30S ribosomal subunits
JMH49_RS03805	COG0739	heme binding
JMH49_RS03810	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
JMH49_RS03815	COG0640	Transcriptional regulator
JMH49_RS03820	COG2217	Heavy metal translocating P-type atpase
JMH49_RS03825	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
JMH49_RS03830	COG0017	Asparaginyl-tRNA synthetase
JMH49_RS03835	COG0561	phosphatase activity
JMH49_RS03840	COG0384	phenazine biosynthesis protein PhzF
JMH49_RS03850	COG0124	histidyl-tRNA synthetase
JMH49_RS03860	COG3842	ATPase activity
JMH49_RS03875	COG1573	uracil-dna glycosylase
JMH49_RS03895	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JMH49_RS03900	COG0519	Catalyzes the synthesis of GMP from XMP
JMH49_RS03900	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JMH49_RS03910	COG1316	TRANSCRIPTIONal
JMH49_RS03920	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
JMH49_RS03965	COG0295	cytidine deaminase activity
JMH49_RS03975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JMH49_RS03985	COG1760	l-serine dehydratase
JMH49_RS03995	COG0481	GTPase activity
JMH49_RS04005	COG0463	Glycosyl transferase, family 2
JMH49_RS04020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JMH49_RS04035	COG1028	Short-chain dehydrogenase reductase Sdr
JMH49_RS04060	COG0405	Gamma-glutamyltransferase
JMH49_RS04065	COG1073	alpha beta
JMH49_RS04085	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JMH49_RS04090	COG2873	o-acetylhomoserine
JMH49_RS04105	COG1063	alcohol dehydrogenase
JMH49_RS04120	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
JMH49_RS04130	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
JMH49_RS04135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JMH49_RS04140	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
JMH49_RS04185	COG0167	dihydroorotate dehydrogenase activity
JMH49_RS04195	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JMH49_RS04200	COG0540	Belongs to the ATCase OTCase family
JMH49_RS04205	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
JMH49_RS04215	COG0730	response to heat
JMH49_RS04220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JMH49_RS04230	COG1960	acyl-CoA dehydrogenase activity
JMH49_RS04235	COG0456	acetyltransferase
JMH49_RS04245	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JMH49_RS04250	COG0009	L-threonylcarbamoyladenylate synthase
JMH49_RS04255	COG1459	type II secretion system
JMH49_RS04270	COG0277	FAD linked oxidase domain protein
JMH49_RS04290	COG0287	Prephenate dehydrogenase
JMH49_RS04295	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
JMH49_RS04300	COG2514	catechol 2,3-dioxygenase activity
JMH49_RS04305	COG2353	YceI-like domain
JMH49_RS04310	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
JMH49_RS04315	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
JMH49_RS04335	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
JMH49_RS04340	COG0179	Fumarylacetoacetate (FAA) hydrolase
JMH49_RS04350	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
JMH49_RS04355	COG0151	Belongs to the GarS family
JMH49_RS04360	COG2176	DNA-directed DNA polymerase activity
JMH49_RS04360	COG5002	protein histidine kinase activity
JMH49_RS04390	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JMH49_RS04400	COG0217	transcriptional regulatory protein
JMH49_RS04405	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JMH49_RS04405	COG4651	solute:proton antiporter activity
JMH49_RS04410	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JMH49_RS04415	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
JMH49_RS04420	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
JMH49_RS04440	COG0517	IMP dehydrogenase activity
JMH49_RS04455	COG3620	sequence-specific DNA binding
JMH49_RS04455	COG0617	tRNA 3'-terminal CCA addition
JMH49_RS04455	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
JMH49_RS04465	COG1994	Peptidase M50
JMH49_RS04470	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
JMH49_RS04480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JMH49_RS04495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JMH49_RS04505	COG2719	SpoVR family
JMH49_RS04510	COG2718	Belongs to the UPF0229 family
JMH49_RS04515	COG2766	serine protein kinase
JMH49_RS04540	COG2137	regulation of response to DNA damage stimulus
JMH49_RS04550	COG2359	stage V sporulation protein S
JMH49_RS04555	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JMH49_RS04560	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JMH49_RS04570	COG0463	Glycosyl transferase, family 2
JMH49_RS04575	COG0750	zinc metalloprotease
JMH49_RS04580	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JMH49_RS04585	COG4589	Belongs to the CDS family
JMH49_RS04590	COG0233	cytoplasmic translational termination
JMH49_RS04595	COG0528	UMP kinase activity
JMH49_RS04600	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JMH49_RS04605	COG0052	Belongs to the universal ribosomal protein uS2 family
JMH49_RS04615	COG0582	viral genome integration into host DNA
JMH49_RS04690	COG0535	radical SAM domain protein
JMH49_RS04750	COG4966	pilus assembly protein PilW
JMH49_RS04825	COG1525	nuclease
JMH49_RS04840	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JMH49_RS04845	COG0494	nUDIX hydrolase
JMH49_RS04885	COG0402	S-adenosylhomocysteine deaminase activity
JMH49_RS04895	COG4948	Mandelate Racemase Muconate Lactonizing
JMH49_RS04900	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
JMH49_RS04905	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JMH49_RS04910	COG1811	Na channel or pump
JMH49_RS04915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JMH49_RS04915	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
JMH49_RS04930	COG1215	transferase activity, transferring glycosyl groups
JMH49_RS04940	COG1215	transferase activity, transferring glycosyl groups
JMH49_RS04950	COG0438	transferase activity, transferring glycosyl groups
JMH49_RS04955	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
JMH49_RS04970	COG1024	Enoyl-CoA hydratase
JMH49_RS04970	COG1250	3-hydroxyacyl-CoA dehydrogenase
JMH49_RS04975	COG0183	Belongs to the thiolase family
JMH49_RS04980	COG1960	acyl-CoA dehydrogenase activity
JMH49_RS04985	COG0215	cysteine-tRNA ligase activity
JMH49_RS04990	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JMH49_RS05000	COG2738	Putative neutral zinc metallopeptidase
JMH49_RS05030	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
JMH49_RS05035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JMH49_RS05035	COG3153	acetyltransferase
JMH49_RS05040	COG1268	BioY protein
JMH49_RS05050	COG0126	phosphoglycerate kinase activity
JMH49_RS05055	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JMH49_RS05060	COG0824	Thioesterase
JMH49_RS05070	COG0557	exoribonuclease II activity
JMH49_RS05080	COG1355	regulation of microtubule-based process
JMH49_RS05085	COG1353	crispr-associated protein
JMH49_RS05085	COG0617	tRNA 3'-terminal CCA addition
JMH49_RS05090	COG0237	dephospho-CoA kinase activity
JMH49_RS05105	COG0742	ribosomal rna small subunit methyltransferase
JMH49_RS05110	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
JMH49_RS05115	COG0138	bifunctional purine biosynthesis protein purh
JMH49_RS05120	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
JMH49_RS05135	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JMH49_RS05170	COG0149	triose-phosphate isomerase activity
JMH49_RS05175	COG3239	Fatty acid desaturase
JMH49_RS05180	COG1490	D-aminoacyl-tRNA deacylase activity
JMH49_RS05185	COG1307	EDD domain protein, DegV family
JMH49_RS05190	COG1307	EDD domain protein, DegV family
JMH49_RS05195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JMH49_RS05200	COG1510	regulation of RNA biosynthetic process
JMH49_RS05210	COG3769	mannosylglycerate metabolic process
JMH49_RS05220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JMH49_RS05230	COG1012	belongs to the aldehyde dehydrogenase family
JMH49_RS05235	COG2368	4-hydroxyphenylacetate
JMH49_RS05240	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JMH49_RS05270	COG2050	protein possibly involved in aromatic compounds catabolism
JMH49_RS05275	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
JMH49_RS05285	COG1012	belongs to the aldehyde dehydrogenase family
JMH49_RS05285	COG2030	dehydratase
JMH49_RS05305	COG3396	Phenylacetate-CoA oxygenase
JMH49_RS05315	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
JMH49_RS05325	COG0395	ABC-type sugar transport system, permease component
JMH49_RS05345	COG1980	fructose-bisphosphate aldolase activity
JMH49_RS05350	COG1733	regulation of RNA biosynthetic process
JMH49_RS05360	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
JMH49_RS05365	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
JMH49_RS05375	COG1331	Highly conserved protein containing a thioredoxin domain
JMH49_RS05380	COG0183	Belongs to the thiolase family
JMH49_RS05385	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JMH49_RS05420	COG0745	RESPONSE REGULATOR receiver
JMH49_RS05425	COG1012	belongs to the aldehyde dehydrogenase family
JMH49_RS05435	COG0248	Ppx GppA phosphatase
JMH49_RS05440	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
JMH49_RS05465	COG0745	RESPONSE REGULATOR receiver
JMH49_RS05470	COG2205	protein histidine kinase activity
JMH49_RS05490	COG1136	(ABC) transporter
JMH49_RS05495	COG0577	efflux transmembrane transporter activity
JMH49_RS05495	COG1136	(ABC) transporter
JMH49_RS05555	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JMH49_RS05620	COG2897	thiosulfate sulfurtransferase activity
JMH49_RS05625	COG1760	l-serine dehydratase
JMH49_RS05630	COG2197	response regulator
JMH49_RS05635	COG0335	large ribosomal subunit rRNA binding
JMH49_RS05640	COG0336	Belongs to the RNA methyltransferase TrmD family
JMH49_RS05645	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JMH49_RS05650	COG1837	Belongs to the UPF0109 family
JMH49_RS05655	COG0228	four-way junction DNA binding
JMH49_RS05670	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JMH49_RS05675	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JMH49_RS05675	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JMH49_RS05680	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JMH49_RS05690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JMH49_RS05700	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JMH49_RS05705	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
JMH49_RS05710	COG1702	phosphate starvation-inducible protein PhoH
JMH49_RS05720	COG4864	UPF0365 protein
JMH49_RS05730	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JMH49_RS05750	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JMH49_RS05750	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JMH49_RS05760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JMH49_RS05770	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
JMH49_RS05775	COG1397	ADP-ribosylglycohydrolase
JMH49_RS05780	COG2239	Acts as a magnesium transporter
JMH49_RS05790	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JMH49_RS05790	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JMH49_RS05800	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JMH49_RS05800	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JMH49_RS05805	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
JMH49_RS05810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JMH49_RS05815	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JMH49_RS05820	COG0006	proline dipeptidase activity
JMH49_RS05830	COG0739	heme binding
JMH49_RS05840	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
JMH49_RS05845	COG0254	rRNA binding
JMH49_RS05860	COG2001	Belongs to the MraZ family
JMH49_RS05865	COG0275	rRNA processing
JMH49_RS05875	COG0768	penicillin binding
JMH49_RS05880	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JMH49_RS05890	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JMH49_RS05895	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JMH49_RS05900	COG0772	Belongs to the SEDS family
JMH49_RS05905	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JMH49_RS05910	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JMH49_RS05915	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JMH49_RS05935	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
JMH49_RS05945	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
JMH49_RS05955	COG0159	tryptophan synthase activity
JMH49_RS05960	COG0133	tryptophan synthase activity
JMH49_RS05965	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
JMH49_RS05970	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JMH49_RS05975	COG1744	ABC transporter substrate-binding protein PnrA-like
JMH49_RS05980	COG3845	ABC transporter
JMH49_RS06030	COG0438	transferase activity, transferring glycosyl groups
JMH49_RS06035	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
JMH49_RS06045	COG0039	L-malate dehydrogenase activity
JMH49_RS06050	COG2819	hydrolase of the alpha beta superfamily
JMH49_RS06055	COG0861	Integral membrane protein TerC family
JMH49_RS06065	COG2181	nitrate reductase activity
JMH49_RS06065	COG0247	lactate metabolic process
JMH49_RS06075	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
JMH49_RS06080	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JMH49_RS06085	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JMH49_RS06095	COG0439	Biotin carboxylase
JMH49_RS06100	COG0511	ligase activity, forming carbon-carbon bonds
JMH49_RS06105	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JMH49_RS06125	COG0010	Belongs to the arginase family
JMH49_RS06140	COG1100	Small GTP-binding protein
JMH49_RS06150	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JMH49_RS06155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JMH49_RS06170	COG2814	Major facilitator Superfamily
JMH49_RS06175	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JMH49_RS06180	COG1185	polyribonucleotide nucleotidyltransferase activity
JMH49_RS06185	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
JMH49_RS06195	COG0745	RESPONSE REGULATOR receiver
JMH49_RS06200	COG5002	protein histidine kinase activity
JMH49_RS06205	COG1960	acyl-CoA dehydrogenase activity
JMH49_RS06210	COG2086	electron transfer activity
JMH49_RS06215	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
JMH49_RS06225	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JMH49_RS06230	COG1573	uracil-dna glycosylase
JMH49_RS06235	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JMH49_RS06235	COG1796	DNA polymerase
JMH49_RS06245	COG2309	aminopeptidase activity
JMH49_RS06260	COG2873	o-acetylhomoserine
JMH49_RS06265	COG2358	TRAP transporter, solute receptor (TAXI family
JMH49_RS06285	COG1752	Esterase of the alpha-beta hydrolase superfamily
JMH49_RS06290	COG0134	indole-3-glycerol-phosphate synthase activity
JMH49_RS06295	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JMH49_RS06305	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JMH49_RS06320	COG0765	amino acid transport
JMH49_RS06325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JMH49_RS06335	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JMH49_RS06340	COG0569	domain protein
JMH49_RS06345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JMH49_RS06350	COG1426	Protein conserved in bacteria
JMH49_RS06355	COG2313	pseudouridylate synthase activity
JMH49_RS06365	COG3001	Fructosamine kinase
JMH49_RS06370	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JMH49_RS06380	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
JMH49_RS06405	COG0012	GTP binding
JMH49_RS06410	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
JMH49_RS06420	COG0424	maF-like protein
JMH49_RS06435	COG0768	penicillin binding
JMH49_RS06445	COG2322	membrane
JMH49_RS06460	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
JMH49_RS06465	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
JMH49_RS06475	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JMH49_RS06490	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
JMH49_RS06530	COG1131	(ABC) transporter
JMH49_RS06545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JMH49_RS06560	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JMH49_RS06565	COG0440	acetolactate synthase activity
JMH49_RS06570	COG0028	Belongs to the TPP enzyme family
JMH49_RS06575	COG0492	ferredoxin-NADP+ reductase activity
JMH49_RS06580	COG4970	Tfp pilus assembly protein FimT
JMH49_RS06605	COG2165	general secretion pathway protein
JMH49_RS06635	COG0180	Tryptophanyl-tRNA synthetase
JMH49_RS06640	COG0544	peptidyl-prolyl cis-trans isomerase activity
JMH49_RS06645	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JMH49_RS06650	COG0066	3-isopropylmalate dehydratase activity
JMH49_RS06655	COG0473	3-isopropylmalate dehydrogenase activity
JMH49_RS06670	COG0300	oxidoreductase activity
JMH49_RS06675	COG0129	dihydroxy-acid dehydratase activity
JMH49_RS06685	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
JMH49_RS06690	COG1177	transmembrane transport
JMH49_RS06695	COG1176	ABC-type spermidine putrescine transport system, permease component I
JMH49_RS06700	COG3842	ATPase activity
JMH49_RS06705	COG0772	Belongs to the SEDS family
JMH49_RS06710	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
JMH49_RS06715	COG2894	cell division
JMH49_RS06720	COG1733	regulation of RNA biosynthetic process
JMH49_RS06730	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JMH49_RS06730	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JMH49_RS06740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JMH49_RS06745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JMH49_RS06750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JMH49_RS06755	COG0653	protein targeting
JMH49_RS06760	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JMH49_RS06780	COG0393	Putative heavy-metal-binding
JMH49_RS06785	COG1111	helicase
JMH49_RS06785	COG1205	dead DEAH box helicase
JMH49_RS06800	COG0358	DNA primase activity
JMH49_RS06810	COG1250	3-hydroxyacyl-CoA dehydrogenase
JMH49_RS06815	COG0697	spore germination
JMH49_RS06820	COG0612	Peptidase, M16
JMH49_RS06825	COG0612	Peptidase, M16
JMH49_RS06830	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JMH49_RS06850	COG1394	ATPase activity, coupled to movement of substances
JMH49_RS06855	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
JMH49_RS06860	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
JMH49_RS06865	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
JMH49_RS06870	COG1527	subunit (C
JMH49_RS06875	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
JMH49_RS06885	COG1269	ATP hydrolysis coupled proton transport
JMH49_RS06910	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
JMH49_RS06920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JMH49_RS06935	COG0419	ATPase involved in DNA repair
JMH49_RS06940	COG0420	3'-5' exonuclease activity
JMH49_RS06960	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JMH49_RS06965	COG2884	Cell division ATP-binding protein ftsE
JMH49_RS06970	COG0793	Belongs to the peptidase S41A family
JMH49_RS06980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JMH49_RS06980	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JMH49_RS06985	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
JMH49_RS06990	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JMH49_RS07000	COG1079	Belongs to the binding-protein-dependent transport system permease family
JMH49_RS07005	COG4603	Belongs to the binding-protein-dependent transport system permease family
JMH49_RS07010	COG1129	ABC transporter
JMH49_RS07015	COG0746	molybdenum cofactor guanylyltransferase activity
JMH49_RS07030	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JMH49_RS07050	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JMH49_RS07055	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JMH49_RS07060	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
JMH49_RS07070	COG1994	Peptidase M50
JMH49_RS07070	COG0517	IMP dehydrogenase activity
JMH49_RS07075	COG2358	TRAP transporter, solute receptor (TAXI family
JMH49_RS07085	COG2358	TRAP transporter, solute receptor (TAXI family
JMH49_RS07105	COG0788	formyltetrahydrofolate deformylase activity
JMH49_RS07110	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JMH49_RS07115	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
JMH49_RS07120	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JMH49_RS07140	COG0737	Belongs to the 5'-nucleotidase family
JMH49_RS07145	COG0174	glutamine synthetase
JMH49_RS07155	COG0559	Belongs to the binding-protein-dependent transport system permease family
JMH49_RS07175	COG0747	negative chemotaxis
JMH49_RS07180	COG0601	transmembrane transport
JMH49_RS07185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JMH49_RS07195	COG0285	dihydrofolate synthase activity
JMH49_RS07200	COG1132	(ABC) transporter
JMH49_RS07205	COG1132	(ABC) transporter
JMH49_RS07210	COG0372	Belongs to the citrate synthase family
JMH49_RS07215	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JMH49_RS07220	COG1482	cell wall glycoprotein biosynthetic process
JMH49_RS07230	COG1515	deoxyribonuclease V activity
JMH49_RS07240	COG0776	regulation of translation
JMH49_RS07255	COG2197	response regulator
JMH49_RS07270	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JMH49_RS07275	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
JMH49_RS07280	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JMH49_RS07285	COG1324	tolerance protein
JMH49_RS07300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JMH49_RS07320	COG2205	protein histidine kinase activity
JMH49_RS07330	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
JMH49_RS07360	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
JMH49_RS07365	COG0247	lactate metabolic process
JMH49_RS07370	COG1139	Iron-sulfur cluster binding protein
JMH49_RS07375	COG1556	Lactate utilization protein
JMH49_RS07385	COG1752	Esterase of the alpha-beta hydrolase superfamily
JMH49_RS07390	COG2815	serine threonine protein kinase
JMH49_RS07390	COG0515	serine threonine protein kinase
JMH49_RS07400	COG0860	N-Acetylmuramoyl-L-alanine amidase
JMH49_RS07410	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
JMH49_RS07440	COG0473	3-isopropylmalate dehydrogenase activity
JMH49_RS07465	COG1450	Type ii and iii secretion system protein
JMH49_RS07470	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JMH49_RS07475	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JMH49_RS07480	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JMH49_RS07485	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
JMH49_RS07485	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JMH49_RS07490	COG0736	holo-[acyl-carrier-protein] synthase activity
JMH49_RS07505	COG1160	GTP binding
JMH49_RS07510	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
JMH49_RS07515	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JMH49_RS07515	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
JMH49_RS07520	COG0083	homoserine kinase activity
JMH49_RS07535	COG0268	Binds directly to 16S ribosomal RNA
JMH49_RS07545	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JMH49_RS07550	COG0723	plastoquinol--plastocyanin reductase activity
JMH49_RS07560	COG4235	cytochrome complex assembly
JMH49_RS07560	COG3088	subunit of a heme lyase
JMH49_RS07565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JMH49_RS07570	COG1138	Cytochrome C-type biogenesis protein
JMH49_RS07575	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
JMH49_RS07580	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JMH49_RS07585	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JMH49_RS07590	COG4133	protoheme IX ABC transporter activity
JMH49_RS07595	COG0785	Cytochrome C biogenesis protein
JMH49_RS07600	COG3258	Cytochrome c
JMH49_RS07610	COG0446	pyridine nucleotide-disulphide oxidoreductase
JMH49_RS07625	COG3258	Cytochrome c
JMH49_RS07630	COG2010	Cytochrome c
JMH49_RS07635	COG0737	Belongs to the 5'-nucleotidase family
JMH49_RS07640	COG2010	Cytochrome c
JMH49_RS07645	COG3258	Cytochrome c
JMH49_RS07665	COG2010	Cytochrome c
JMH49_RS07670	COG3842	ATPase activity
JMH49_RS07700	COG0318	PFAM AMP-dependent synthetase and ligase
JMH49_RS07700	COG0318	PFAM AMP-dependent synthetase and ligase
JMH49_RS07705	COG3360	Dodecin
JMH49_RS07720	COG1024	Enoyl-CoA hydratase
JMH49_RS07725	COG0813	purine-nucleoside phosphorylase activity
JMH49_RS07730	COG1136	(ABC) transporter
JMH49_RS07735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JMH49_RS07740	COG2045	Belongs to the ComB family
JMH49_RS07750	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JMH49_RS07760	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
JMH49_RS07770	COG0107	imidazoleglycerol-phosphate synthase activity
JMH49_RS07775	COG0140	phosphoribosyl-ATP diphosphatase activity
JMH49_RS07775	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JMH49_RS07785	COG1494	fructose-1,6-bisphosphatase
JMH49_RS07790	COG0686	Belongs to the AlaDH PNT family
JMH49_RS07795	COG0427	acetyl-CoA hydrolase
JMH49_RS07800	COG0084	hydrolase, TatD family'
JMH49_RS07805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JMH49_RS07815	COG0017	Asparaginyl-tRNA synthetase
JMH49_RS07825	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JMH49_RS07840	COG2009	succinate dehydrogenase
JMH49_RS07845	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
JMH49_RS07875	COG0318	PFAM AMP-dependent synthetase and ligase
JMH49_RS07880	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JMH49_RS07885	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JMH49_RS07890	COG0504	CTP synthase activity
JMH49_RS07905	COG0067	glutamate synthase
JMH49_RS07905	COG0069	glutamate synthase activity
JMH49_RS07905	COG0070	glutamate synthase
JMH49_RS07910	COG0840	transmembrane signaling receptor activity
JMH49_RS07915	COG0305	Participates in initiation and elongation during chromosome replication
JMH49_RS07925	COG0475	glutathione-regulated potassium exporter activity
JMH49_RS07930	COG0617	tRNA 3'-terminal CCA addition
JMH49_RS07930	COG0517	IMP dehydrogenase activity
JMH49_RS07930	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
JMH49_RS07945	COG0475	glutathione-regulated potassium exporter activity
JMH49_RS07950	COG0490	domain, Protein
JMH49_RS07970	COG3118	belongs to the thioredoxin family
JMH49_RS08000	COG0542	response to heat
JMH49_RS08005	COG0789	Transcriptional regulator
JMH49_RS08010	COG0484	heat shock protein binding
JMH49_RS08015	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JMH49_RS08020	COG0443	Heat shock 70 kDa protein
JMH49_RS08025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JMH49_RS08030	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JMH49_RS08035	COG0616	signal peptide processing
JMH49_RS08050	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
JMH49_RS08055	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JMH49_RS08060	COG0714	Associated with various cellular activities
JMH49_RS08065	COG0574	Belongs to the PEP-utilizing enzyme family
JMH49_RS08065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JMH49_RS08070	COG1272	protein, Hemolysin III
JMH49_RS08080	COG3850	Histidine kinase
JMH49_RS08080	COG5002	protein histidine kinase activity
JMH49_RS08095	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JMH49_RS08110	COG1011	Hydrolase
JMH49_RS08130	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JMH49_RS08145	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JMH49_RS08155	COG0047	phosphoribosylformylglycinamidine synthase activity
JMH49_RS08165	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JMH49_RS08170	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
JMH49_RS08175	COG0116	Belongs to the methyltransferase superfamily
JMH49_RS08190	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JMH49_RS08195	COG0497	DNA recombination
JMH49_RS08205	COG0604	alcohol dehydrogenase
JMH49_RS08225	COG0585	pseudouridine synthase activity
JMH49_RS08240	COG0557	exoribonuclease II activity
JMH49_RS08245	COG0473	3-isopropylmalate dehydrogenase activity
JMH49_RS08260	COG4974	Belongs to the 'phage' integrase family
JMH49_RS08275	COG0037	tRNA processing
JMH49_RS08275	COG0590	tRNA wobble adenosine to inosine editing
JMH49_RS08300	COG2050	protein possibly involved in aromatic compounds catabolism
JMH49_RS08310	COG0322	excinuclease ABC activity
JMH49_RS08315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JMH49_RS08320	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JMH49_RS08325	COG1854	S-ribosylhomocysteine lyase activity
JMH49_RS08330	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JMH49_RS08330	COG0519	Catalyzes the synthesis of GMP from XMP
JMH49_RS08340	COG4274	PFAM GYD family protein
JMH49_RS08345	COG0346	lactoylglutathione lyase activity
JMH49_RS08350	COG0328	RNA-DNA hybrid ribonuclease activity
JMH49_RS08355	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JMH49_RS08360	COG2095	MarC family integral membrane protein
JMH49_RS08365	COG1438	arginine binding
JMH49_RS08370	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JMH49_RS08375	COG1758	RNA polymerase activity
JMH49_RS08380	COG0194	GDP metabolic process
JMH49_RS08390	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JMH49_RS08395	COG2385	sporulation resulting in formation of a cellular spore
JMH49_RS08400	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
JMH49_RS08410	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
JMH49_RS08450	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JMH49_RS08455	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JMH49_RS08460	COG1012	belongs to the aldehyde dehydrogenase family
JMH49_RS08465	COG0506	proline dehydrogenase activity
JMH49_RS08495	COG0156	8-amino-7-oxononanoate synthase activity
JMH49_RS08500	COG0732	type I restriction modification DNA specificity domain
JMH49_RS08500	COG0827	DNA restriction-modification system
JMH49_RS08515	COG0187	DNA topoisomerase II activity
JMH49_RS08520	COG1181	Belongs to the D-alanine--D-alanine ligase family
JMH49_RS08525	COG0193	aminoacyl-tRNA hydrolase activity
JMH49_RS08530	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
JMH49_RS08560	COG0631	protein serine/threonine phosphatase activity
JMH49_RS08570	COG2814	Major facilitator Superfamily
JMH49_RS08575	COG0113	porphobilinogen synthase activity
JMH49_RS08580	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JMH49_RS08585	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JMH49_RS08610	COG1506	peptidase
JMH49_RS08610	COG0823	Involved in the tonB-independent uptake of proteins
JMH49_RS08610	COG4946	Tricorn protease homolog
JMH49_RS08615	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JMH49_RS08620	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JMH49_RS08640	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JMH49_RS08645	COG1011	Hydrolase
JMH49_RS08670	COG0537	adenosine 5'-monophosphoramidase activity
JMH49_RS08675	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JMH49_RS08680	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JMH49_RS08685	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
JMH49_RS08690	COG0071	Belongs to the small heat shock protein (HSP20) family
JMH49_RS08695	COG2897	thiosulfate sulfurtransferase activity
JMH49_RS08700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JMH49_RS08710	COG1764	response to oxidative stress
JMH49_RS08735	COG3842	ATPase activity
JMH49_RS08740	COG0101	tRNA pseudouridine synthase activity
JMH49_RS08745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JMH49_RS08750	COG0601	transmembrane transport
JMH49_RS08765	COG0006	proline dipeptidase activity
JMH49_RS08770	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JMH49_RS08785	COG1166	arginine decarboxylase activity
JMH49_RS08790	COG3706	GGDEF domain
JMH49_RS08795	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JMH49_RS08800	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JMH49_RS08805	COG1611	Belongs to the LOG family
JMH49_RS08810	COG1193	negative regulation of DNA recombination
JMH49_RS08875	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
JMH49_RS08880	COG0142	geranyltranstransferase activity
JMH49_RS08895	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
JMH49_RS08925	COG0203	ribosomal protein L17
JMH49_RS08930	COG0202	RNA polymerase activity
JMH49_RS08935	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JMH49_RS08940	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JMH49_RS08945	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JMH49_RS08955	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
JMH49_RS08965	COG0563	adenylate kinase activity
JMH49_RS08970	COG0201	protein transport
JMH49_RS08995	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JMH49_RS09000	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JMH49_RS09005	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JMH49_RS09020	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JMH49_RS09030	COG0255	Belongs to the universal ribosomal protein uL29 family
JMH49_RS09035	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JMH49_RS09040	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JMH49_RS09050	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JMH49_RS09055	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JMH49_RS09060	COG0089	rRNA binding
JMH49_RS09065	COG0088	Forms part of the polypeptide exit tunnel
JMH49_RS09075	COG0051	transcription antitermination factor activity, RNA binding
JMH49_RS09090	COG0049	tRNA binding
JMH49_RS09105	COG0442	prolyl-tRNA aminoacylation
JMH49_RS09125	COG1115	amino acid carrier protein
JMH49_RS09145	COG1489	DNA binding
JMH49_RS09175	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JMH49_RS09195	COG0432	Pfam Uncharacterised protein family UPF0047
JMH49_RS09200	COG3253	May function as heme-dependent peroxidase
JMH49_RS09205	COG0668	transmembrane transport
JMH49_RS09215	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JMH49_RS09220	COG2217	Heavy metal translocating P-type atpase
JMH49_RS09240	COG0745	RESPONSE REGULATOR receiver
JMH49_RS09245	COG2205	protein histidine kinase activity
JMH49_RS09270	COG2226	methyltransferase
JMH49_RS09290	COG2132	Multicopper oxidase
JMH49_RS09315	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JMH49_RS09320	COG0822	iron-sulfur transferase activity
JMH49_RS09340	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JMH49_RS09350	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JMH49_RS09355	COG0284	orotidine-5'-phosphate decarboxylase activity
JMH49_RS09370	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JMH49_RS09380	COG0416	fatty acid biosynthetic process
JMH49_RS09385	COG3118	belongs to the thioredoxin family
JMH49_RS09390	COG1185	polyribonucleotide nucleotidyltransferase activity
JMH49_RS09395	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JMH49_RS09405	COG0438	transferase activity, transferring glycosyl groups
JMH49_RS09425	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JMH49_RS09440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JMH49_RS09445	COG3706	GGDEF domain
JMH49_RS09475	COG0437	4 iron, 4 sulfur cluster binding
JMH49_RS09490	COG0825	malonyl-CoA metabolic process
JMH49_RS09495	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JMH49_RS09530	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
JMH49_RS09555	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
JMH49_RS09565	COG0211	Belongs to the bacterial ribosomal protein bL27 family
JMH49_RS09570	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JMH49_RS09610	COG0315	cyclic pyranopterin monophosphate synthase activity
JMH49_RS09620	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
JMH49_RS09635	COG0477	Major facilitator Superfamily
JMH49_RS09640	COG1694	Mazg nucleotide pyrophosphohydrolase
JMH49_RS09645	COG1803	Methylglyoxal synthase
JMH49_RS09655	COG0301	tRNA thio-modification
JMH49_RS09660	COG0154	amidase activity
JMH49_RS09700	COG2154	pterin-4-alpha-carbinolamine dehydratase
JMH49_RS09705	COG1607	acyl-coa hydrolase
JMH49_RS09715	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JMH49_RS09720	COG4149	molybdate abc transporter
JMH49_RS09725	COG1840	ABC-type Fe3 transport system, periplasmic component
JMH49_RS09740	COG0235	Class ii aldolase
JMH49_RS09745	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JMH49_RS09750	COG0085	RNA polymerase activity
JMH49_RS09760	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JMH49_RS09765	COG1077	Cell shape determining protein MreB Mrl
JMH49_RS09770	COG1418	mRNA catabolic process
JMH49_RS09770	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
JMH49_RS09775	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JMH49_RS09780	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
JMH49_RS09785	COG1058	Belongs to the CinA family
JMH49_RS09785	COG1546	Belongs to the CinA family
JMH49_RS09790	COG0354	folic acid binding
JMH49_RS09805	COG4948	Mandelate Racemase Muconate Lactonizing
JMH49_RS09820	COG1175	transmembrane transport
JMH49_RS09830	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JMH49_RS09840	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JMH49_RS09850	COG1136	(ABC) transporter
JMH49_RS09850	COG0577	efflux transmembrane transporter activity
JMH49_RS09855	COG4181	ATPase activity
JMH49_RS09860	COG0446	pyridine nucleotide-disulphide oxidoreductase
JMH49_RS09875	COG0396	ATPase activity
JMH49_RS09880	COG0719	Fe-S assembly protein
JMH49_RS09885	COG0719	Fe-S assembly protein
JMH49_RS09890	COG2146	nitrite reductase [NAD(P)H] activity
JMH49_RS09900	COG0512	Glutamine amidotransferase of anthranilate synthase
JMH49_RS09905	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JMH49_RS09945	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JMH49_RS09950	COG2226	methyltransferase
JMH49_RS09955	COG4603	Belongs to the binding-protein-dependent transport system permease family
JMH49_RS09960	COG1079	Belongs to the binding-protein-dependent transport system permease family
JMH49_RS09975	COG1774	PSP1 C-terminal conserved region
JMH49_RS09980	COG0470	DNA polymerase III
JMH49_RS10000	COG0497	DNA recombination
JMH49_RS10040	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JMH49_RS10055	COG0302	gtp cyclohydrolase
JMH49_RS10085	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JMH49_RS10095	COG0395	ABC-type sugar transport system, permease component
JMH49_RS10110	COG1131	(ABC) transporter
JMH49_RS10130	COG0556	nucleotide-excision repair
JMH49_RS10135	COG0497	DNA recombination
JMH49_RS10140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JMH49_RS10150	COG0445	tRNA wobble uridine modification
JMH49_RS10175	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JMH49_RS10175	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JMH49_RS10180	COG1543	Belongs to the glycosyl hydrolase 57 family
JMH49_RS10185	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JMH49_RS10190	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
JMH49_RS10195	COG0189	ligase activity
JMH49_RS10210	COG0066	3-isopropylmalate dehydratase activity
JMH49_RS10215	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JMH49_RS10220	COG1598	PFAM Uncharacterised protein family UPF0150
JMH49_RS10230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JMH49_RS10235	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JMH49_RS10240	COG1960	acyl-CoA dehydrogenase activity
JMH49_RS10245	COG0163	prenyltransferase activity
JMH49_RS10290	COG4555	ABC transporter
JMH49_RS10300	COG2096	Adenosyltransferase
JMH49_RS10320	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
JMH49_RS10325	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
JMH49_RS10335	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
JMH49_RS10340	COG0723	plastoquinol--plastocyanin reductase activity
JMH49_RS10365	COG1653	transport
JMH49_RS10370	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JMH49_RS10375	COG1960	acyl-CoA dehydrogenase activity
JMH49_RS10385	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JMH49_RS10405	COG0393	Putative heavy-metal-binding
JMH49_RS10415	COG3956	TIGRFAM MazG family protein
JMH49_RS10425	COG0693	protein deglycase activity
JMH49_RS10430	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JMH49_RS10440	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JMH49_RS10445	COG1937	Protein conserved in bacteria
JMH49_RS10455	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JMH49_RS10455	COG0674	pyruvate-flavodoxin oxidoreductase activity
JMH49_RS10460	COG1013	pyruvate-flavodoxin oxidoreductase activity
JMH49_RS10465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JMH49_RS10485	COG0205	6-phosphofructokinase activity
JMH49_RS10490	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
JMH49_RS10500	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
JMH49_RS10515	COG0658	competence protein
JMH49_RS10515	COG2333	competence protein COMEC
JMH49_RS10520	COG1475	DNA binding
JMH49_RS10525	COG1192	Involved in chromosome partitioning
JMH49_RS10530	COG0357	Ribosomal RNA small subunit methyltransferase G
JMH49_RS10535	COG0445	tRNA wobble uridine modification
JMH49_RS10560	COG2211	Major facilitator Superfamily
JMH49_RS10605	COG1337	RAMP superfamily
JMH49_RS10665	COG1518	maintenance of DNA repeat elements
JMH49_RS10685	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
JMH49_RS10755	COG0411	ABC transporter
JMH49_RS10760	COG0318	PFAM AMP-dependent synthetase and ligase
JMH49_RS10785	COG1960	acyl-CoA dehydrogenase activity
JMH49_RS10795	COG1028	Short-chain dehydrogenase reductase Sdr
JMH49_RS10800	COG1012	belongs to the aldehyde dehydrogenase family
JMH49_RS10800	COG2030	dehydratase
JMH49_RS10810	COG0318	PFAM AMP-dependent synthetase and ligase
JMH49_RS10815	COG1028	Short-chain dehydrogenase reductase Sdr
JMH49_RS10835	COG0588	phosphoglycerate mutase activity
JMH49_RS10965	COG2329	Antibiotic biosynthesis monooxygenase
JMH49_RS10975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JMH49_RS10980	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
JMH49_RS10990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JMH49_RS11040	COG1403	HNH endonuclease
JMH49_RS11090	COG2181	nitrate reductase activity
JMH49_RS11100	COG1140	nitrate reductase beta subunit
JMH49_RS11125	COG2010	Cytochrome c
JMH49_RS11135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JMH49_RS11145	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
JMH49_RS11160	COG1252	NADH dehydrogenase
JMH49_RS11165	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JMH49_RS11175	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
JMH49_RS11245	COG2010	Cytochrome c
JMH49_RS11250	COG0535	radical SAM domain protein
JMH49_RS11260	COG2832	Protein of unknown function (DUF454)
JMH49_RS11270	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JMH49_RS11360	COG1475	DNA binding
JMH49_RS11410	COG1487	ribonuclease activity
JMH49_RS11445	COG1562	ergosterol biosynthetic process
JMH49_RS11515	COG2723	6-phospho-beta-galactosidase activity
JMH49_RS11525	COG1175	transmembrane transport
JMH49_RS11535	COG1609	Transcriptional regulator
JMH49_RS11555	COG1028	Short-chain dehydrogenase reductase Sdr
JMH49_RS11575	COG0800	Aldolase
JMH49_RS11585	COG1175	transmembrane transport
JMH49_RS11590	COG0395	ABC-type sugar transport system, permease component
JMH49_RS11630	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JMH49_RS11650	COG0778	Nitroreductase
JMH49_RS11700	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
JMH49_RS11725	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
JMH49_RS11735	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
JMH49_RS11790	COG1129	ABC transporter
JMH49_RS11795	COG1879	ABC-type sugar transport system periplasmic component
JMH49_RS11810	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JMH49_RS11840	COG1475	DNA binding
JMH49_RS11845	COG1192	Involved in chromosome partitioning
JMH49_RS11875	COG1012	belongs to the aldehyde dehydrogenase family
JMH49_RS11880	COG1172	Belongs to the binding-protein-dependent transport system permease family
JMH49_RS11885	COG1129	ABC transporter
JMH49_RS11890	COG3962	Belongs to the TPP enzyme family
JMH49_RS11900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JMH49_RS11910	COG0673	inositol 2-dehydrogenase activity
JMH49_RS11915	COG3718	enzyme involved in inositol metabolism
JMH49_RS11920	COG1349	DNA-binding transcription factor activity
JMH49_RS11940	COG3842	ATPase activity
JMH49_RS11960	COG3842	ATPase activity
JMH49_RS11965	COG1175	transmembrane transport
JMH49_RS11975	COG0395	ABC-type sugar transport system, permease component
JMH49_RS11990	COG0434	BtpA family
JMH49_RS11995	COG1349	DNA-binding transcription factor activity
JMH49_RS12045	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JMH49_RS12060	COG2002	toxin-antitoxin pair type II binding
JMH49_RS12200	COG3335	DDE superfamily endonuclease
JMH49_RS12220	COG1074	ATP-dependent DNA helicase activity
JMH49_RS12235	COG1203	CRISPR-associated helicase, Cas3
JMH49_RS12285	COG0300	oxidoreductase activity
JMH49_RS12290	COG0673	inositol 2-dehydrogenase activity
JMH49_RS12300	COG1070	Carbohydrate kinase
JMH49_RS12315	COG1129	ABC transporter
JMH49_RS12320	COG4214	carbohydrate transport
JMH49_RS12325	COG4213	ABC transporter substrate-binding protein
JMH49_RS12340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JMH49_RS12345	COG4597	amino acid ABC transporter
JMH49_RS12350	COG0765	amino acid transport
JMH49_RS12440	COG1028	Short-chain dehydrogenase reductase Sdr
JMH49_RS12450	COG2030	dehydratase
JMH49_RS12450	COG1012	belongs to the aldehyde dehydrogenase family
JMH49_RS12455	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
JMH49_RS12460	COG0804	urea catabolic process
JMH49_RS12460	COG0832	Belongs to the urease beta subunit family
JMH49_RS12465	COG0183	Belongs to the thiolase family
JMH49_RS12480	COG1129	ABC transporter
JMH49_RS12505	COG1012	belongs to the aldehyde dehydrogenase family
JMH49_RS12510	COG1024	Enoyl-CoA hydratase
JMH49_RS12515	COG1309	transcriptional regulator
JMH49_RS12525	COG1024	Enoyl-CoA hydratase
JMH49_RS12665	COG1172	Belongs to the binding-protein-dependent transport system permease family
JMH49_RS12695	COG2211	Major facilitator Superfamily
JMH49_RS12750	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JMH49_RS12765	COG2010	Cytochrome c
JMH49_RS12770	COG0535	radical SAM domain protein
JMH49_RS12775	COG2132	Multicopper oxidase
JMH49_RS12780	COG2832	Protein of unknown function (DUF454)
JMH49_RS12790	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JMH49_RS12855	COG0243	molybdopterin cofactor binding
JMH49_RS12865	COG1192	Involved in chromosome partitioning
JMH49_RS12870	COG1475	DNA binding
JMH49_RS12880	COG1475	DNA binding
JMH49_RS12895	COG3345	alpha-galactosidase
JMH49_RS12900	COG1085	galactose-1-phosphate uridylyltransferase
JMH49_RS12920	COG1304	FMN binding
JMH49_RS12930	COG1487	ribonuclease activity
JMH49_RS12955	COG2124	cytochrome p450
JMH49_RS12965	COG1562	ergosterol biosynthetic process
JMH49_RS12975	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JMH49_RS13005	COG0702	epimerase
JMH49_RS13010	COG1233	COG1233 Phytoene dehydrogenase and related
JMH49_RS13030	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
JMH49_RS13035	COG2723	6-phospho-beta-galactosidase activity
JMH49_RS13045	COG1175	transmembrane transport
JMH49_RS13060	COG1028	Short-chain dehydrogenase reductase Sdr
JMH49_RS13075	COG1028	Short-chain dehydrogenase reductase Sdr
JMH49_RS13080	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
JMH49_RS13095	COG0800	Aldolase
JMH49_RS13105	COG1175	transmembrane transport
JMH49_RS13110	COG0395	ABC-type sugar transport system, permease component
JMH49_RS13140	COG1785	Belongs to the alkaline phosphatase family
JMH49_RS13145	COG1492	cobalamin metabolic process
JMH49_RS13150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JMH49_RS13170	COG0778	Nitroreductase
JMH49_RS13175	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JMH49_RS13175	COG1648	precorrin-2 dehydrogenase activity
JMH49_RS13220	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
JMH49_RS13225	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
JMH49_RS13230	COG0588	phosphoglycerate mutase activity
JMH49_RS13245	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
JMH49_RS13255	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
JMH49_RS13260	COG1797	cobyrinic acid a,c-diamide synthase activity