locus-tag	class	description
TTHA0001	COG0592	DNA-directed DNA polymerase activity
TTHA0002	COG0148	phosphopyruvate hydratase activity
TTHA0003	COG0469	pyruvate kinase activity
TTHA0005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TTHA0006	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TTHA0008	COG1842	Phage shock protein A
TTHA0011	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TTHA0013	COG0142	geranyltranstransferase activity
TTHA0015	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TTHA0016	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TTHA0018	COG0297	glycogen (starch) synthase activity
TTHA0019	COG2105	PFAM AIG2 family protein
TTHA0020	COG0745	RESPONSE REGULATOR receiver
TTHA0022	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TTHA0023	COG1067	ATP-dependent peptidase activity
TTHA0027	COG0667	Aldo Keto reductase
TTHA0032	COG2002	toxin-antitoxin pair type II binding
TTHA0040	COG0277	FAD linked oxidase domain protein
TTHA0042	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TTHA0044	COG0475	glutathione-regulated potassium exporter activity
TTHA0044	COG0569	domain protein
TTHA0046	COG0436	Aminotransferase
TTHA0049	COG1597	lipid kinase activity
TTHA0052	COG0123	including yeast histone deacetylase and acetoin utilization protein
TTHA0054	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TTHA0056	COG0004	ammonium transporteR
TTHA0057	COG0347	Belongs to the P(II) protein family
TTHA0058	COG1420	regulation of RNA biosynthetic process
TTHA0059	COG0314	molybdopterin synthase activity
TTHA0062	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TTHA0063	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TTHA0065	COG0277	FAD linked oxidase domain protein
TTHA0071	COG1126	abc transporter atp-binding protein
TTHA0072	COG2720	vancomycin resistance protein
TTHA0074	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TTHA0075	COG1372	Participates in initiation and elongation during chromosome replication
TTHA0075	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TTHA0076	COG0135	phosphoribosylanthranilate isomerase activity
TTHA0079	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TTHA0081	COG4712	double-strand break repair protein
TTHA0083	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TTHA0084	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTHA0085	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTHA0086	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTHA0087	COG0649	NAD binding
TTHA0088	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TTHA0089	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TTHA0090	COG1034	ATP synthesis coupled electron transport
TTHA0091	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TTHA0092	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTHA0093	COG0839	Belongs to the complex I subunit 6 family
TTHA0094	COG0713	ATP synthesis coupled electron transport
TTHA0095	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TTHA0096	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTHA0097	COG1007	ATP synthesis coupled electron transport
TTHA0098	COG0018	arginyl-trna synthetase
TTHA0099	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TTHA0100	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TTHA0103	COG2070	2-Nitropropane dioxygenase
TTHA0106	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TTHA0109	COG0513	Belongs to the DEAD box helicase family
TTHA0110	COG0303	'Molybdopterin
TTHA0114	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TTHA0115	COG0442	prolyl-tRNA aminoacylation
TTHA0116	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TTHA0118	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TTHA0120	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TTHA0121	COG0758	DNA mediated transformation
TTHA0121	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TTHA0122	COG3546	catalase activity
TTHA0123	COG0583	DNA-binding transcription factor activity
TTHA0127	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TTHA0128	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TTHA0129	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TTHA0130	COG0717	Belongs to the dCTP deaminase family
TTHA0133	COG1028	Short-chain dehydrogenase reductase Sdr
TTHA0134	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TTHA0138	COG0515	serine threonine protein kinase
TTHA0138	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TTHA0140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TTHA0142	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TTHA0143	COG0704	Plays a role in the regulation of phosphate uptake
TTHA0144	COG4191	Histidine kinase
TTHA0145	COG0745	RESPONSE REGULATOR receiver
TTHA0146	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TTHA0148	COG1187	pseudouridine synthase activity
TTHA0152	COG2414	aldehyde ferredoxin oxidoreductase
TTHA0157	COG1902	pentaerythritol trinitrate reductase activity
TTHA0161	COG0495	leucyl-tRNA aminoacylation
TTHA0162	COG0539	negative regulation of cytoplasmic translation
TTHA0163	COG0802	atpase or kinase
TTHA0166	COG4242	Belongs to the peptidase S51 family
TTHA0167	COG1309	transcriptional regulator
TTHA0170	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TTHA0171	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TTHA0172	COG1968	undecaprenyl-diphosphatase activity
TTHA0173	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TTHA0174	COG0484	heat shock protein binding
TTHA0175	COG1278	Cold shock
TTHA0177	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TTHA0184	COG0508	dehydrogenase complex catalyzes the overall conversion of
TTHA0186	COG0583	DNA-binding transcription factor activity
TTHA0187	COG0631	protein serine/threonine phosphatase activity
TTHA0188	COG0105	UTP biosynthetic process
TTHA0190	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TTHA0193	COG0477	Major facilitator Superfamily
TTHA0196	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TTHA0198	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TTHA0199	COG2272	Belongs to the type-B carboxylesterase lipase family
TTHA0200	COG0243	molybdopterin cofactor binding
TTHA0202	COG3177	Filamentation induced by cAMP protein fic
TTHA0204	COG0697	spore germination
TTHA0207	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TTHA0209	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TTHA0210	COG0222	ribosome binding
TTHA0211	COG4591	ABC-type transport system involved in lipoprotein release permease component
TTHA0212	COG3583	domain protein
TTHA0212	COG3584	3D domain protein
TTHA0214	COG1461	Dihydroxyacetone kinase
TTHA0216	COG0686	Belongs to the AlaDH PNT family
TTHA0217	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TTHA0219	COG1187	pseudouridine synthase activity
TTHA0220	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TTHA0222	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TTHA0223	COG2226	methyltransferase
TTHA0228	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TTHA0229	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TTHA0230	COG0022	dehydrogenase e1 component
TTHA0231	COG1598	PFAM Uncharacterised protein family UPF0150
TTHA0233	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TTHA0239	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TTHA0240	COG0321	lipoyl(octanoyl) transferase activity
TTHA0241	COG0300	oxidoreductase activity
TTHA0242	COG0359	binds to the 23S rRNA
TTHA0243	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TTHA0244	COG0629	single-stranded DNA binding
TTHA0246	COG0081	regulation of translation
TTHA0248	COG0250	Participates in transcription elongation, termination and antitermination
TTHA0249	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TTHA0250	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TTHA0251	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TTHA0252	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TTHA0255	COG0735	belongs to the Fur family
TTHA0256	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TTHA0258	COG0482	sulfurtransferase activity
TTHA0259	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TTHA0260	COG0573	inorganic phosphate transmembrane transporter activity
TTHA0261	COG0581	inorganic phosphate transmembrane transporter activity
TTHA0262	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TTHA0264	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TTHA0266	COG1388	LysM domain
TTHA0266	COG0791	NLP P60 protein
TTHA0267	COG0778	Nitroreductase
TTHA0269	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TTHA0270	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TTHA0271	COG0459	protein refolding
TTHA0272	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TTHA0275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TTHA0277	COG0166	Belongs to the GPI family
TTHA0278	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TTHA0280	COG0505	Belongs to the CarA family
TTHA0283	COG0165	Argininosuccinate lyase
TTHA0284	COG0137	argininosuccinate synthase activity
TTHA0286	COG1404	Belongs to the peptidase S8 family
TTHA0288	COG0508	dehydrogenase complex catalyzes the overall conversion of
TTHA0290	COG1024	Enoyl-CoA hydratase
TTHA0291	COG0632	four-way junction helicase activity
TTHA0292	COG1011	Hydrolase
TTHA0294	COG1611	Belongs to the LOG family
TTHA0296	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TTHA0297	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TTHA0299	COG1940	carbohydrate kinase activity
TTHA0304	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TTHA0305	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TTHA0306	COG0343	queuine tRNA-ribosyltransferase activity
TTHA0310	COG1612	heme a metabolic process
TTHA0310	COG0109	protoheme IX farnesyltransferase activity
TTHA0311	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TTHA0311	COG2010	Cytochrome c
TTHA0312	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TTHA0312	COG1845	cytochrome c oxidase, subunit III
TTHA0318	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TTHA0319	COG1660	Displays ATPase and GTPase activities
TTHA0320	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TTHA0323	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TTHA0324	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TTHA0327	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TTHA0328	COG1335	isochorismatase
TTHA0329	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TTHA0331	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TTHA0333	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TTHA0334	COG1993	acr, cog1993
TTHA0335	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TTHA0336	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TTHA0341	COG0521	Mo-molybdopterin cofactor biosynthetic process
TTHA0342	COG0436	Aminotransferase
TTHA0343	COG0285	dihydrofolate synthase activity
TTHA0345	COG0181	hydroxymethylbilane synthase activity
TTHA0347	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TTHA0348	COG1950	PFAM Membrane protein of
TTHA0349	COG0517	IMP dehydrogenase activity
TTHA0349	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TTHA0353	COG0033	Phosphoglucomutase
TTHA0356	COG1653	transport
TTHA0359	COG1278	Cold shock
TTHA0362	COG1496	oxidoreductase activity
TTHA0363	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TTHA0364	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TTHA0366	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TTHA0367	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TTHA0368	COG0406	alpha-ribazole phosphatase activity
TTHA0369	COG1028	Short-chain dehydrogenase reductase Sdr
TTHA0370	COG0492	ferredoxin-NADP+ reductase activity
TTHA0372	COG0792	nuclease activity
TTHA0373	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TTHA0378	COG0395	ABC-type sugar transport system, permease component
TTHA0384	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TTHA0385	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TTHA0386	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TTHA0387	COG0805	protein transport
TTHA0388	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TTHA0388	COG1605	Chorismate mutase
TTHA0400	COG1063	alcohol dehydrogenase
TTHA0406	COG2255	four-way junction helicase activity
TTHA0407	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TTHA0408	COG0564	pseudouridine synthase activity
TTHA0411	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TTHA0412	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TTHA0413	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TTHA0414	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TTHA0416	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TTHA0417	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TTHA0418	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TTHA0425	COG0778	Nitroreductase
TTHA0428	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TTHA0429	COG0131	Imidazoleglycerol-phosphate dehydratase
TTHA0430	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TTHA0431	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TTHA0432	COG0517	IMP dehydrogenase activity
TTHA0432	COG0516	GMP reductase activity
TTHA0435	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TTHA0438	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TTHA0443	COG0706	membrane insertase activity
TTHA0444	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TTHA0445	COG0594	ribonuclease P activity
TTHA0446	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TTHA0448	COG1022	Amp-dependent synthetase and ligase
TTHA0453	COG1121	(ABC) transporter
TTHA0454	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TTHA0455	COG1959	2 iron, 2 sulfur cluster binding
TTHA0456	COG1104	cysteine desulfurase activity
TTHA0457	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TTHA0458	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TTHA0461	COG1028	Short-chain dehydrogenase reductase Sdr
TTHA0465	COG0492	ferredoxin-NADP+ reductase activity
TTHA0466	COG0604	alcohol dehydrogenase
TTHA0466	COG1028	Short-chain dehydrogenase reductase Sdr
TTHA0466	COG3321	synthase
TTHA0469	COG0747	negative chemotaxis
TTHA0470	COG0601	transmembrane transport
TTHA0471	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TTHA0474	COG0517	IMP dehydrogenase activity
TTHA0475	COG0123	including yeast histone deacetylase and acetoin utilization protein
TTHA0476	COG2104	thiamine diphosphate biosynthetic process
TTHA0477	COG0037	tRNA processing
TTHA0480	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
TTHA0481	COG0366	Alpha amylase catalytic
TTHA0482	COG2226	methyltransferase
TTHA0483	COG2226	methyltransferase
TTHA0484	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TTHA0486	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TTHA0487	COG3744	PilT protein domain protein
TTHA0489	COG0460	homoserine dehydrogenase
TTHA0491	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TTHA0497	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TTHA0501	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
TTHA0503	COG0247	lactate metabolic process
TTHA0504	COG0277	FAD linked oxidase domain protein
TTHA0505	COG0277	FAD linked oxidase domain protein
TTHA0506	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TTHA0507	COG1414	Transcriptional regulator
TTHA0508	COG0789	Transcriptional regulator
TTHA0510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TTHA0511	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TTHA0518	COG0861	Integral membrane protein TerC family
TTHA0519	COG2151	metal-sulfur cluster biosynthetic enzyme
TTHA0520	COG0281	malic enzyme
TTHA0523	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TTHA0524	COG0509	glycine decarboxylation via glycine cleavage system
TTHA0525	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TTHA0526	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TTHA0527	COG0196	riboflavin kinase activity
TTHA0532	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TTHA0533	COG2813	Specifically methylates the guanine in position
TTHA0534	COG0527	aspartate kinase activity
TTHA0540	COG4956	integral membrane protein (PIN domain superfamily)
TTHA0541	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TTHA0542	COG0542	response to heat
TTHA0543	COG0423	glycine-tRNA ligase activity
TTHA0545	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TTHA0549	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TTHA0549	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TTHA0551	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TTHA0553	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TTHA0555	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TTHA0556	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TTHA0557	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TTHA0558	COG0114	fumarate hydratase activity
TTHA0559	COG0183	Belongs to the thiolase family
TTHA0562	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TTHA0563	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TTHA0566	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TTHA0567	COG1254	Belongs to the acylphosphatase family
TTHA0569	COG1063	alcohol dehydrogenase
TTHA0570	COG2133	pyrroloquinoline quinone binding
TTHA0572	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TTHA0573	COG0154	amidase activity
TTHA0578	COG0572	uridine kinase
TTHA0579	COG3842	ATPase activity
TTHA0583	COG4475	Protein of unknown function (DUF436)
TTHA0594	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TTHA0595	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TTHA0596	COG0803	Belongs to the bacterial solute-binding protein 9 family
TTHA0599	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TTHA0600	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TTHA0601	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TTHA0602	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TTHA0604	COG0318	PFAM AMP-dependent synthetase and ligase
TTHA0606	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TTHA0607	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TTHA0608	COG1293	RNA-binding protein homologous to eukaryotic snRNP
TTHA0609	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TTHA0611	COG3870	Protein conserved in bacteria
TTHA0612	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TTHA0614	COG0544	peptidyl-prolyl cis-trans isomerase activity
TTHA0615	COG0740	serine-type endopeptidase activity
TTHA0616	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TTHA0617	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TTHA0618	COG0646	methionine synthase
TTHA0618	COG1410	methionine synthase
TTHA0620	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TTHA0625	COG1692	metallophosphoesterase
TTHA0626	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TTHA0627	COG1970	mechanosensitive ion channel activity
TTHA0628	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TTHA0630	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TTHA0631	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TTHA0642	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TTHA0650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TTHA0654	COG0489	protein tyrosine kinase activity
TTHA0656	COG2264	protein methyltransferase activity
TTHA0657	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TTHA0663	COG0574	Belongs to the PEP-utilizing enzyme family
TTHA0663	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TTHA0665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TTHA0666	COG2046	Belongs to the sulfate adenylyltransferase family
TTHA0668	COG0730	response to heat
TTHA0669	COG0175	sulfate reduction
TTHA0670	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TTHA0670	COG1648	precorrin-2 dehydrogenase activity
TTHA0671	COG1587	Uroporphyrinogen-III synthase
TTHA0672	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TTHA0674	COG0352	thiamine-phosphate diphosphorylase activity
TTHA0675	COG2104	thiamine diphosphate biosynthetic process
TTHA0676	COG2022	thiamine diphosphate biosynthetic process
TTHA0677	COG2022	thiamine diphosphate biosynthetic process
TTHA0677	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TTHA0678	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TTHA0679	COG0477	Major facilitator Superfamily
TTHA0680	COG0351	phosphomethylpyrimidine kinase
TTHA0689	COG1940	carbohydrate kinase activity
TTHA0690	COG0183	Belongs to the thiolase family
TTHA0693	COG1028	Short-chain dehydrogenase reductase Sdr
TTHA0697	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TTHA0697	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TTHA0699	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TTHA0701	COG0195	Participates in both transcription termination and antitermination
TTHA0702	COG0779	Required for maturation of 30S ribosomal subunits
TTHA0703	COG0739	heme binding
TTHA0704	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TTHA0705	COG0640	Transcriptional regulator
TTHA0706	COG2217	Heavy metal translocating P-type atpase
TTHA0707	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TTHA0708	COG0017	Asparaginyl-tRNA synthetase
TTHA0709	COG0561	phosphatase activity
TTHA0710	COG0384	phenazine biosynthesis protein PhzF
TTHA0712	COG0124	histidyl-tRNA synthetase
TTHA0715	COG3842	ATPase activity
TTHA0718	COG1573	uracil-dna glycosylase
TTHA0722	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TTHA0723	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TTHA0723	COG0519	Catalyzes the synthesis of GMP from XMP
TTHA0725	COG1316	TRANSCRIPTIONal
TTHA0726	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TTHA0735	COG0295	cytidine deaminase activity
TTHA0737	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TTHA0739	COG1760	l-serine dehydratase
TTHA0741	COG0481	GTPase activity
TTHA0743	COG0463	Glycosyl transferase, family 2
TTHA0747	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TTHA0750	COG1028	Short-chain dehydrogenase reductase Sdr
TTHA0755	COG0405	Gamma-glutamyltransferase
TTHA0756	COG1073	alpha beta
TTHA0759	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TTHA0760	COG2873	o-acetylhomoserine
TTHA0763	COG1063	alcohol dehydrogenase
TTHA0765	COG3191	aminopeptidase activity
TTHA0766	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TTHA0768	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TTHA0769	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TTHA0770	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TTHA0779	COG0167	dihydroorotate dehydrogenase activity
TTHA0781	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TTHA0782	COG0540	Belongs to the ATCase OTCase family
TTHA0783	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TTHA0785	COG0730	response to heat
TTHA0786	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TTHA0789	COG1960	acyl-CoA dehydrogenase activity
TTHA0790	COG0456	acetyltransferase
TTHA0792	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TTHA0793	COG0009	L-threonylcarbamoyladenylate synthase
TTHA0794	COG1459	type II secretion system
TTHA0797	COG0277	FAD linked oxidase domain protein
TTHA0799	COG0287	Prephenate dehydrogenase
TTHA0800	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TTHA0801	COG2514	catechol 2,3-dioxygenase activity
TTHA0802	COG2353	YceI-like domain
TTHA0803	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TTHA0804	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TTHA0807	COG1609	Transcriptional regulator
TTHA0808	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TTHA0809	COG0179	Fumarylacetoacetate (FAA) hydrolase
TTHA0811	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TTHA0812	COG0151	Belongs to the GarS family
TTHA0813	COG2176	DNA-directed DNA polymerase activity
TTHA0813	COG5002	protein histidine kinase activity
TTHA0819	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TTHA0821	COG0217	transcriptional regulatory protein
TTHA0822	COG4651	solute:proton antiporter activity
TTHA0822	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TTHA0823	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TTHA0824	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TTHA0825	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TTHA0826	COG1674	ftsk spoiiie
TTHA0829	COG0517	IMP dehydrogenase activity
TTHA0831	COG0617	tRNA 3'-terminal CCA addition
TTHA0831	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TTHA0831	COG3620	sequence-specific DNA binding
TTHA0833	COG1994	Peptidase M50
TTHA0834	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TTHA0836	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TTHA0839	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TTHA0841	COG2719	SpoVR family
TTHA0842	COG2718	Belongs to the UPF0229 family
TTHA0843	COG2766	serine protein kinase
TTHA0848	COG2137	regulation of response to DNA damage stimulus
TTHA0850	COG2359	stage V sporulation protein S
TTHA0851	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TTHA0852	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TTHA0854	COG0463	Glycosyl transferase, family 2
TTHA0855	COG0750	zinc metalloprotease
TTHA0856	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TTHA0857	COG4589	Belongs to the CDS family
TTHA0858	COG0233	cytoplasmic translational termination
TTHA0859	COG0528	UMP kinase activity
TTHA0860	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TTHA0861	COG0052	Belongs to the universal ribosomal protein uS2 family
TTHA0862	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TTHA0863	COG0494	nUDIX hydrolase
TTHA0872	COG0402	S-adenosylhomocysteine deaminase activity
TTHA0874	COG4948	Mandelate Racemase Muconate Lactonizing
TTHA0875	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TTHA0876	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TTHA0877	COG1811	Na channel or pump
TTHA0878	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TTHA0878	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TTHA0881	COG1215	transferase activity, transferring glycosyl groups
TTHA0885	COG1215	transferase activity, transferring glycosyl groups
TTHA0887	COG0438	transferase activity, transferring glycosyl groups
TTHA0888	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TTHA0890	COG1250	3-hydroxyacyl-CoA dehydrogenase
TTHA0890	COG1024	Enoyl-CoA hydratase
TTHA0891	COG0183	Belongs to the thiolase family
TTHA0892	COG1960	acyl-CoA dehydrogenase activity
TTHA0893	COG0215	cysteine-tRNA ligase activity
TTHA0894	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TTHA0896	COG2738	Putative neutral zinc metallopeptidase
TTHA0899	COG1196	nuclear chromosome segregation
TTHA0902	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TTHA0903	COG3153	acetyltransferase
TTHA0903	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TTHA0904	COG1268	BioY protein
TTHA0906	COG0126	phosphoglycerate kinase activity
TTHA0907	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TTHA0908	COG0824	Thioesterase
TTHA0910	COG0557	exoribonuclease II activity
TTHA0924	COG1355	regulation of microtubule-based process
TTHA0925	COG1353	crispr-associated protein
TTHA0925	COG0617	tRNA 3'-terminal CCA addition
TTHA0926	COG0237	dephospho-CoA kinase activity
TTHA0928	COG0742	ribosomal rna small subunit methyltransferase
TTHA0929	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TTHA0930	COG0138	bifunctional purine biosynthesis protein purh
TTHA0931	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TTHA0934	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TTHA0947	COG0149	triose-phosphate isomerase activity
TTHA0948	COG3239	Fatty acid desaturase
TTHA0949	COG1490	D-aminoacyl-tRNA deacylase activity
TTHA0950	COG1307	EDD domain protein, DegV family
TTHA0951	COG1307	EDD domain protein, DegV family
TTHA0952	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TTHA0953	COG1510	regulation of RNA biosynthetic process
TTHA0955	COG3769	mannosylglycerate metabolic process
TTHA0957	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TTHA0959	COG1012	belongs to the aldehyde dehydrogenase family
TTHA0960	COG2368	4-hydroxyphenylacetate
TTHA0961	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TTHA0965	COG2050	protein possibly involved in aromatic compounds catabolism
TTHA0966	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TTHA0968	COG2030	dehydratase
TTHA0968	COG1012	belongs to the aldehyde dehydrogenase family
TTHA0972	COG3396	Phenylacetate-CoA oxygenase
TTHA0974	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TTHA0976	COG0395	ABC-type sugar transport system, permease component
TTHA0980	COG1980	fructose-bisphosphate aldolase activity
TTHA0981	COG1733	regulation of RNA biosynthetic process
TTHA0982	COG2193	ferroxidase activity
TTHA0983	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TTHA0984	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TTHA0986	COG1331	Highly conserved protein containing a thioredoxin domain
TTHA0987	COG0183	Belongs to the thiolase family
TTHA0988	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TTHA0996	COG1012	belongs to the aldehyde dehydrogenase family
TTHA0997	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TTHA1002	COG0745	RESPONSE REGULATOR receiver
TTHA1003	COG2205	protein histidine kinase activity
TTHA1006	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TTHA1007	COG1136	(ABC) transporter
TTHA1008	COG1136	(ABC) transporter
TTHA1008	COG0577	efflux transmembrane transporter activity
TTHA1009	COG1309	transcriptional regulator
TTHA1020	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TTHA1027	COG0582	viral genome integration into host DNA
TTHA1028	COG2897	thiosulfate sulfurtransferase activity
TTHA1029	COG1760	l-serine dehydratase
TTHA1030	COG2197	response regulator
TTHA1031	COG0335	large ribosomal subunit rRNA binding
TTHA1032	COG0336	Belongs to the RNA methyltransferase TrmD family
TTHA1033	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TTHA1034	COG1837	Belongs to the UPF0109 family
TTHA1035	COG0228	four-way junction DNA binding
TTHA1038	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TTHA1039	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TTHA1039	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TTHA1040	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TTHA1042	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TTHA1044	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TTHA1045	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TTHA1046	COG1702	phosphate starvation-inducible protein PhoH
TTHA1048	COG4864	UPF0365 protein
TTHA1050	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TTHA1054	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TTHA1054	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TTHA1056	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TTHA1058	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TTHA1059	COG1397	ADP-ribosylglycohydrolase
TTHA1060	COG2239	Acts as a magnesium transporter
TTHA1062	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TTHA1062	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TTHA1064	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TTHA1064	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TTHA1065	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TTHA1066	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TTHA1067	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TTHA1068	COG0006	proline dipeptidase activity
TTHA1070	COG0739	heme binding
TTHA1072	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TTHA1073	COG0254	rRNA binding
TTHA1075	COG2001	Belongs to the MraZ family
TTHA1076	COG0275	rRNA processing
TTHA1078	COG0768	penicillin binding
TTHA1079	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TTHA1081	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TTHA1082	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TTHA1083	COG0772	Belongs to the SEDS family
TTHA1085	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TTHA1086	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TTHA1090	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TTHA1092	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TTHA1094	COG0159	tryptophan synthase activity
TTHA1095	COG0133	tryptophan synthase activity
TTHA1096	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TTHA1097	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TTHA1098	COG1744	ABC transporter substrate-binding protein PnrA-like
TTHA1099	COG3845	ABC transporter
TTHA1111	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TTHA1113	COG0039	L-malate dehydrogenase activity
TTHA1114	COG2819	hydrolase of the alpha beta superfamily
TTHA1115	COG0861	Integral membrane protein TerC family
TTHA1117	COG0247	lactate metabolic process
TTHA1117	COG2181	nitrate reductase activity
TTHA1119	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TTHA1120	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TTHA1121	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TTHA1123	COG0439	Biotin carboxylase
TTHA1124	COG0511	ligase activity, forming carbon-carbon bonds
TTHA1125	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TTHA1129	COG0010	Belongs to the arginase family
TTHA1132	COG1100	Small GTP-binding protein
TTHA1134	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TTHA1135	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TTHA1137	COG2814	Major facilitator Superfamily
TTHA1138	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TTHA1139	COG1185	polyribonucleotide nucleotidyltransferase activity
TTHA1140	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TTHA1142	COG0745	RESPONSE REGULATOR receiver
TTHA1143	COG5002	protein histidine kinase activity
TTHA1144	COG1960	acyl-CoA dehydrogenase activity
TTHA1145	COG2086	electron transfer activity
TTHA1146	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TTHA1148	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TTHA1149	COG1573	uracil-dna glycosylase
TTHA1150	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TTHA1150	COG1796	DNA polymerase
TTHA1152	COG2309	aminopeptidase activity
TTHA1156	COG2873	o-acetylhomoserine
TTHA1157	COG2358	TRAP transporter, solute receptor (TAXI family
TTHA1159	COG1126	abc transporter atp-binding protein
TTHA1161	COG1752	Esterase of the alpha-beta hydrolase superfamily
TTHA1162	COG3311	Transcriptional regulator
TTHA1164	COG0134	indole-3-glycerol-phosphate synthase activity
TTHA1165	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TTHA1167	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TTHA1170	COG0765	amino acid transport
TTHA1171	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TTHA1173	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TTHA1174	COG0569	domain protein
TTHA1175	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TTHA1176	COG1426	Protein conserved in bacteria
TTHA1177	COG2313	pseudouridylate synthase activity
TTHA1179	COG3001	Fructosamine kinase
TTHA1180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TTHA1182	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TTHA1185	COG0012	GTP binding
TTHA1186	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TTHA1188	COG0424	maF-like protein
TTHA1191	COG0768	penicillin binding
TTHA1193	COG2322	membrane
TTHA1196	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TTHA1197	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TTHA1199	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TTHA1203	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TTHA1205	COG1131	(ABC) transporter
TTHA1208	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TTHA1211	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TTHA1212	COG0440	acetolactate synthase activity
TTHA1213	COG0028	Belongs to the TPP enzyme family
TTHA1215	COG0492	ferredoxin-NADP+ reductase activity
TTHA1216	COG4970	Tfp pilus assembly protein FimT
TTHA1221	COG2165	general secretion pathway protein
TTHA1227	COG0180	Tryptophanyl-tRNA synthetase
TTHA1228	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TTHA1229	COG0066	3-isopropylmalate dehydratase activity
TTHA1230	COG0473	3-isopropylmalate dehydrogenase activity
TTHA1233	COG0300	oxidoreductase activity
TTHA1234	COG0129	dihydroxy-acid dehydratase activity
TTHA1238	COG1177	transmembrane transport
TTHA1239	COG1176	ABC-type spermidine putrescine transport system, permease component I
TTHA1240	COG3842	ATPase activity
TTHA1241	COG0772	Belongs to the SEDS family
TTHA1242	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TTHA1243	COG2894	cell division
TTHA1244	COG1733	regulation of RNA biosynthetic process
TTHA1246	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TTHA1246	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TTHA1248	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TTHA1249	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TTHA1250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TTHA1251	COG0653	protein targeting
TTHA1252	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TTHA1256	COG0393	Putative heavy-metal-binding
TTHA1257	COG1111	helicase
TTHA1257	COG1205	dead DEAH box helicase
TTHA1260	COG0358	DNA primase activity
TTHA1262	COG1250	3-hydroxyacyl-CoA dehydrogenase
TTHA1263	COG0697	spore germination
TTHA1264	COG0612	Peptidase, M16
TTHA1265	COG0612	Peptidase, M16
TTHA1266	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TTHA1271	COG1394	ATPase activity, coupled to movement of substances
TTHA1272	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TTHA1273	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TTHA1274	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TTHA1275	COG1527	subunit (C
TTHA1276	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TTHA1278	COG1269	ATP hydrolysis coupled proton transport
TTHA1283	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TTHA1285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TTHA1288	COG0419	ATPase involved in DNA repair
TTHA1289	COG0420	3'-5' exonuclease activity
TTHA1294	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TTHA1295	COG2884	Cell division ATP-binding protein ftsE
TTHA1296	COG0793	Belongs to the peptidase S41A family
TTHA1298	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TTHA1298	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TTHA1299	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TTHA1300	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TTHA1302	COG1079	Belongs to the binding-protein-dependent transport system permease family
TTHA1303	COG4603	Belongs to the binding-protein-dependent transport system permease family
TTHA1304	COG1129	ABC transporter
TTHA1305	COG0746	molybdenum cofactor guanylyltransferase activity
TTHA1308	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TTHA1312	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TTHA1313	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TTHA1314	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TTHA1316	COG1994	Peptidase M50
TTHA1316	COG0517	IMP dehydrogenase activity
TTHA1317	COG2358	TRAP transporter, solute receptor (TAXI family
TTHA1321	COG0788	formyltetrahydrofolate deformylase activity
TTHA1322	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TTHA1323	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TTHA1324	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TTHA1328	COG0737	Belongs to the 5'-nucleotidase family
TTHA1329	COG0174	glutamine synthetase
TTHA1331	COG0559	Belongs to the binding-protein-dependent transport system permease family
TTHA1336	COG0747	negative chemotaxis
TTHA1337	COG0601	transmembrane transport
TTHA1338	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TTHA1340	COG0285	dihydrofolate synthase activity
TTHA1341	COG1132	(ABC) transporter
TTHA1342	COG1132	(ABC) transporter
TTHA1343	COG0372	Belongs to the citrate synthase family
TTHA1344	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TTHA1345	COG1482	cell wall glycoprotein biosynthetic process
TTHA1347	COG1515	deoxyribonuclease V activity
TTHA1349	COG0776	regulation of translation
TTHA1352	COG2197	response regulator
TTHA1353	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TTHA1354	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TTHA1355	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TTHA1356	COG1324	tolerance protein
TTHA1359	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TTHA1363	COG2205	protein histidine kinase activity
TTHA1365	COG0247	lactate metabolic process
TTHA1366	COG1139	Iron-sulfur cluster binding protein
TTHA1367	COG1556	Lactate utilization protein
TTHA1369	COG1752	Esterase of the alpha-beta hydrolase superfamily
TTHA1370	COG2815	serine threonine protein kinase
TTHA1370	COG0515	serine threonine protein kinase
TTHA1372	COG0860	N-Acetylmuramoyl-L-alanine amidase
TTHA1374	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TTHA1378	COG0473	3-isopropylmalate dehydrogenase activity
TTHA1383	COG1450	Type ii and iii secretion system protein
TTHA1384	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TTHA1385	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TTHA1386	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TTHA1387	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TTHA1387	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TTHA1388	COG0736	holo-[acyl-carrier-protein] synthase activity
TTHA1391	COG1160	GTP binding
TTHA1392	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TTHA1393	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TTHA1393	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TTHA1394	COG0083	homoserine kinase activity
TTHA1397	COG0268	Binds directly to 16S ribosomal RNA
TTHA1399	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TTHA1400	COG0723	plastoquinol--plastocyanin reductase activity
TTHA1402	COG3088	subunit of a heme lyase
TTHA1402	COG4235	cytochrome complex assembly
TTHA1403	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TTHA1404	COG1138	Cytochrome C-type biogenesis protein
TTHA1405	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TTHA1406	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TTHA1407	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TTHA1408	COG4133	protoheme IX ABC transporter activity
TTHA1409	COG0785	Cytochrome C biogenesis protein
TTHA1410	COG3258	Cytochrome c
TTHA1412	COG0446	pyridine nucleotide-disulphide oxidoreductase
TTHA1415	COG3258	Cytochrome c
TTHA1416	COG2010	Cytochrome c
TTHA1417	COG0737	Belongs to the 5'-nucleotidase family
TTHA1418	COG2010	Cytochrome c
TTHA1419	COG3258	Cytochrome c
TTHA1423	COG2010	Cytochrome c
TTHA1424	COG3842	ATPase activity
TTHA1430	COG0318	PFAM AMP-dependent synthetase and ligase
TTHA1431	COG3360	Dodecin
TTHA1434	COG1024	Enoyl-CoA hydratase
TTHA1435	COG0813	purine-nucleoside phosphorylase activity
TTHA1436	COG1136	(ABC) transporter
TTHA1437	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TTHA1438	COG2045	Belongs to the ComB family
TTHA1440	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TTHA1442	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TTHA1444	COG0107	imidazoleglycerol-phosphate synthase activity
TTHA1445	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TTHA1445	COG0140	phosphoribosyl-ATP diphosphatase activity
TTHA1446	COG1494	fructose-1,6-bisphosphatase
TTHA1447	COG0686	Belongs to the AlaDH PNT family
TTHA1448	COG0427	acetyl-CoA hydrolase
TTHA1449	COG0084	hydrolase, TatD family'
TTHA1450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TTHA1452	COG0017	Asparaginyl-tRNA synthetase
TTHA1453	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TTHA1456	COG2009	succinate dehydrogenase
TTHA1457	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TTHA1463	COG0318	PFAM AMP-dependent synthetase and ligase
TTHA1464	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TTHA1465	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TTHA1466	COG0504	CTP synthase activity
TTHA1468	COG0069	glutamate synthase activity
TTHA1468	COG0067	glutamate synthase
TTHA1468	COG0070	glutamate synthase
TTHA1469	COG0840	transmembrane signaling receptor activity
TTHA1470	COG0305	Participates in initiation and elongation during chromosome replication
TTHA1472	COG0475	glutathione-regulated potassium exporter activity
TTHA1473	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TTHA1473	COG0617	tRNA 3'-terminal CCA addition
TTHA1473	COG0517	IMP dehydrogenase activity
TTHA1476	COG0475	glutathione-regulated potassium exporter activity
TTHA1477	COG0490	domain, Protein
TTHA1481	COG3118	belongs to the thioredoxin family
TTHA1487	COG0542	response to heat
TTHA1488	COG0789	Transcriptional regulator
TTHA1489	COG0484	heat shock protein binding
TTHA1490	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TTHA1491	COG0443	Heat shock 70 kDa protein
TTHA1492	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TTHA1493	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TTHA1494	COG0616	signal peptide processing
TTHA1495	COG1714	RDD family
TTHA1497	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
TTHA1498	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TTHA1499	COG0714	Associated with various cellular activities
TTHA1500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TTHA1500	COG0574	Belongs to the PEP-utilizing enzyme family
TTHA1501	COG1272	protein, Hemolysin III
TTHA1503	COG5002	protein histidine kinase activity
TTHA1503	COG3850	Histidine kinase
TTHA1506	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TTHA1509	COG1011	Hydrolase
TTHA1513	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TTHA1515	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TTHA1517	COG0047	phosphoribosylformylglycinamidine synthase activity
TTHA1519	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TTHA1520	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TTHA1521	COG0116	Belongs to the methyltransferase superfamily
TTHA1524	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TTHA1525	COG0497	DNA recombination
TTHA1527	COG0604	alcohol dehydrogenase
TTHA1531	COG0585	pseudouridine synthase activity
TTHA1534	COG0557	exoribonuclease II activity
TTHA1535	COG0473	3-isopropylmalate dehydrogenase activity
TTHA1536	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TTHA1539	COG4974	Belongs to the 'phage' integrase family
TTHA1542	COG0037	tRNA processing
TTHA1542	COG0590	tRNA wobble adenosine to inosine editing
TTHA1546	COG2050	protein possibly involved in aromatic compounds catabolism
TTHA1548	COG0322	excinuclease ABC activity
TTHA1549	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TTHA1550	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TTHA1551	COG1854	S-ribosylhomocysteine lyase activity
TTHA1552	COG0519	Catalyzes the synthesis of GMP from XMP
TTHA1552	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TTHA1553	COG4636	protein conserved in cyanobacteria
TTHA1554	COG4274	PFAM GYD family protein
TTHA1555	COG0346	lactoylglutathione lyase activity
TTHA1556	COG0328	RNA-DNA hybrid ribonuclease activity
TTHA1557	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TTHA1558	COG2095	MarC family integral membrane protein
TTHA1559	COG1438	arginine binding
TTHA1560	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TTHA1561	COG1758	RNA polymerase activity
TTHA1562	COG0194	GDP metabolic process
TTHA1564	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TTHA1565	COG2385	sporulation resulting in formation of a cellular spore
TTHA1566	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
TTHA1568	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TTHA1576	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TTHA1577	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TTHA1578	COG1012	belongs to the aldehyde dehydrogenase family
TTHA1579	COG0506	proline dehydrogenase activity
TTHA1582	COG0156	8-amino-7-oxononanoate synthase activity
TTHA1583	COG0827	DNA restriction-modification system
TTHA1583	COG0732	type I restriction modification DNA specificity domain
TTHA1586	COG0187	DNA topoisomerase II activity
TTHA1587	COG1181	Belongs to the D-alanine--D-alanine ligase family
TTHA1588	COG0193	aminoacyl-tRNA hydrolase activity
TTHA1589	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TTHA1594	COG2815	serine threonine protein kinase
TTHA1594	COG0515	serine threonine protein kinase
TTHA1595	COG0631	protein serine/threonine phosphatase activity
TTHA1597	COG2814	Major facilitator Superfamily
TTHA1598	COG0113	porphobilinogen synthase activity
TTHA1599	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TTHA1600	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TTHA1605	COG0823	Involved in the tonB-independent uptake of proteins
TTHA1605	COG4946	Tricorn protease homolog
TTHA1605	COG1506	peptidase
TTHA1606	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TTHA1607	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TTHA1611	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TTHA1612	COG1011	Hydrolase
TTHA1617	COG0537	adenosine 5'-monophosphoramidase activity
TTHA1618	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TTHA1619	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TTHA1620	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TTHA1621	COG0071	Belongs to the small heat shock protein (HSP20) family
TTHA1622	COG2897	thiosulfate sulfurtransferase activity
TTHA1623	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TTHA1625	COG1764	response to oxidative stress
TTHA1630	COG3842	ATPase activity
TTHA1631	COG0101	tRNA pseudouridine synthase activity
TTHA1632	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TTHA1633	COG0601	transmembrane transport
TTHA1634	COG0747	negative chemotaxis
TTHA1636	COG0006	proline dipeptidase activity
TTHA1637	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TTHA1640	COG1166	arginine decarboxylase activity
TTHA1641	COG3706	GGDEF domain
TTHA1642	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TTHA1643	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TTHA1644	COG1611	Belongs to the LOG family
TTHA1645	COG1193	negative regulation of DNA recombination
TTHA1647	COG0366	Alpha amylase catalytic
TTHA1654	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TTHA1655	COG0142	geranyltranstransferase activity
TTHA1657	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TTHA1663	COG0203	ribosomal protein L17
TTHA1664	COG0202	RNA polymerase activity
TTHA1665	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TTHA1666	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TTHA1667	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TTHA1669	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TTHA1671	COG0563	adenylate kinase activity
TTHA1672	COG0201	protein transport
TTHA1677	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TTHA1678	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TTHA1679	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TTHA1682	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TTHA1683	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TTHA1684	COG0255	Belongs to the universal ribosomal protein uL29 family
TTHA1685	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TTHA1686	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TTHA1688	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TTHA1689	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TTHA1690	COG0089	rRNA binding
TTHA1691	COG0088	Forms part of the polypeptide exit tunnel
TTHA1693	COG0051	transcription antitermination factor activity, RNA binding
TTHA1696	COG0049	tRNA binding
TTHA1699	COG0442	prolyl-tRNA aminoacylation
TTHA1703	COG1115	amino acid carrier protein
TTHA1707	COG1489	DNA binding
TTHA1710	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TTHA1713	COG0432	Pfam Uncharacterised protein family UPF0047
TTHA1714	COG3253	May function as heme-dependent peroxidase
TTHA1715	COG0668	transmembrane transport
TTHA1717	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TTHA1718	COG2217	Heavy metal translocating P-type atpase
TTHA1722	COG0745	RESPONSE REGULATOR receiver
TTHA1723	COG2205	protein histidine kinase activity
TTHA1728	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TTHA1729	COG2226	methyltransferase
TTHA1735	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TTHA1736	COG0822	iron-sulfur transferase activity
TTHA1740	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TTHA1742	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TTHA1743	COG0284	orotidine-5'-phosphate decarboxylase activity
TTHA1744	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TTHA1746	COG0416	fatty acid biosynthetic process
TTHA1747	COG3118	belongs to the thioredoxin family
TTHA1748	COG1185	polyribonucleotide nucleotidyltransferase activity
TTHA1749	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TTHA1751	COG0438	transferase activity, transferring glycosyl groups
TTHA1755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TTHA1757	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TTHA1758	COG3706	GGDEF domain
TTHA1764	COG0437	4 iron, 4 sulfur cluster binding
TTHA1767	COG0825	malonyl-CoA metabolic process
TTHA1768	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TTHA1775	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TTHA1780	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TTHA1781	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TTHA1782	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TTHA1783	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TTHA1789	COG0315	cyclic pyranopterin monophosphate synthase activity
TTHA1790	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TTHA1793	COG1694	Mazg nucleotide pyrophosphohydrolase
TTHA1794	COG1803	Methylglyoxal synthase
TTHA1796	COG0301	tRNA thio-modification
TTHA1797	COG0154	amidase activity
TTHA1798	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TTHA1803	COG2154	pterin-4-alpha-carbinolamine dehydratase
TTHA1804	COG1607	acyl-coa hydrolase
TTHA1806	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TTHA1807	COG4149	molybdate abc transporter
TTHA1808	COG1840	ABC-type Fe3 transport system, periplasmic component
TTHA1811	COG0235	Class ii aldolase
TTHA1812	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TTHA1813	COG0085	RNA polymerase activity
TTHA1815	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TTHA1816	COG1077	Cell shape determining protein MreB Mrl
TTHA1817	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TTHA1817	COG1418	mRNA catabolic process
TTHA1818	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TTHA1819	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TTHA1820	COG1546	Belongs to the CinA family
TTHA1820	COG1058	Belongs to the CinA family
TTHA1821	COG0354	folic acid binding
TTHA1824	COG4948	Mandelate Racemase Muconate Lactonizing
TTHA1827	COG1175	transmembrane transport
TTHA1829	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TTHA1831	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TTHA1833	COG1136	(ABC) transporter
TTHA1833	COG0577	efflux transmembrane transporter activity
TTHA1834	COG4181	ATPase activity
TTHA1835	COG0446	pyridine nucleotide-disulphide oxidoreductase
TTHA1838	COG0396	ATPase activity
TTHA1839	COG0719	Fe-S assembly protein
TTHA1840	COG0719	Fe-S assembly protein
TTHA1841	COG2146	nitrite reductase [NAD(P)H] activity
TTHA1843	COG0512	Glutamine amidotransferase of anthranilate synthase
TTHA1844	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TTHA1853	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TTHA1854	COG2226	methyltransferase
TTHA1855	COG4603	Belongs to the binding-protein-dependent transport system permease family
TTHA1856	COG1079	Belongs to the binding-protein-dependent transport system permease family
TTHA1859	COG1774	PSP1 C-terminal conserved region
TTHA1860	COG0470	DNA polymerase III
TTHA1864	COG0497	DNA recombination
TTHA1875	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TTHA1878	COG0302	gtp cyclohydrolase
TTHA1884	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TTHA1886	COG0395	ABC-type sugar transport system, permease component
TTHA1887	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TTHA1888	COG1131	(ABC) transporter
TTHA1892	COG0556	nucleotide-excision repair
TTHA1893	COG0497	DNA recombination
TTHA1896	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TTHA1897	COG0445	tRNA wobble uridine modification
TTHA1901	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TTHA1901	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TTHA1902	COG1543	Belongs to the glycosyl hydrolase 57 family
TTHA1903	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TTHA1904	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TTHA1907	COG0189	ligase activity
TTHA1910	COG0066	3-isopropylmalate dehydratase activity
TTHA1911	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TTHA1914	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TTHA1915	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TTHA1916	COG1960	acyl-CoA dehydrogenase activity
TTHA1917	COG0163	prenyltransferase activity
TTHA1924	COG4555	ABC transporter
TTHA1926	COG2096	Adenosyltransferase
TTHA1927	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TTHA1928	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TTHA1930	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TTHA1931	COG0723	plastoquinol--plastocyanin reductase activity
TTHA1936	COG1653	transport
TTHA1937	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TTHA1938	COG1960	acyl-CoA dehydrogenase activity
TTHA1940	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TTHA1944	COG0393	Putative heavy-metal-binding
TTHA1946	COG3956	TIGRFAM MazG family protein
TTHA1947	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
TTHA1950	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TTHA1952	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TTHA1953	COG1937	Protein conserved in bacteria
TTHA1955	COG0674	pyruvate-flavodoxin oxidoreductase activity
TTHA1955	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TTHA1956	COG1013	pyruvate-flavodoxin oxidoreductase activity
TTHA1957	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TTHA1962	COG0205	6-phosphofructokinase activity
TTHA1963	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TTHA1965	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TTHA1968	COG2333	competence protein COMEC
TTHA1968	COG0658	competence protein
TTHA1969	COG1475	DNA binding
TTHA1970	COG1192	Involved in chromosome partitioning
TTHA1971	COG0357	Ribosomal RNA small subunit methyltransferase G
TTHA1972	COG0445	tRNA wobble uridine modification
TTHA1973	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TTHAt32	COG0544	peptidyl-prolyl cis-trans isomerase activity
TTHB013	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TTHB016	COG1842	Phage shock protein A
TTHB026	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TTHB094	COG0649	NAD binding
TTHB104	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TTHB107	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTHB110	COG0018	arginyl-trna synthetase
TTHB111	COG0018	arginyl-trna synthetase
TTHB121	COG0303	'Molybdopterin
TTHB122	COG0303	'Molybdopterin
TTHB136	COG3546	catalase activity
TTHB148	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TTHB189	COG0243	molybdopterin cofactor binding
TTHB204	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TTHB207	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TTHC004	COG0469	pyruvate kinase activity