locus-tag	class	description
TthHC11_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TthHC11_RS00010	COG0592	DNA-directed DNA polymerase activity
TthHC11_RS00015	COG0148	phosphopyruvate hydratase activity
TthHC11_RS00020	COG0469	pyruvate kinase activity
TthHC11_RS00030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TthHC11_RS00035	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TthHC11_RS00045	COG1842	Phage shock protein A
TthHC11_RS00070	COG0406	alpha-ribazole phosphatase activity
TthHC11_RS00075	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TthHC11_RS00080	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthHC11_RS00090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TthHC11_RS00095	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TthHC11_RS00100	COG1496	oxidoreductase activity
TthHC11_RS00105	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TthHC11_RS00110	COG1278	Cold shock
TthHC11_RS00115	COG1653	transport
TthHC11_RS00130	COG0033	Phosphoglucomutase
TthHC11_RS00155	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TthHC11_RS00155	COG0517	IMP dehydrogenase activity
TthHC11_RS00160	COG1950	PFAM Membrane protein of
TthHC11_RS00165	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TthHC11_RS00175	COG0181	hydroxymethylbilane synthase activity
TthHC11_RS00185	COG0285	dihydrofolate synthase activity
TthHC11_RS00190	COG0436	Aminotransferase
TthHC11_RS00195	COG0521	Mo-molybdopterin cofactor biosynthetic process
TthHC11_RS00220	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TthHC11_RS00225	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TthHC11_RS00230	COG1993	acr, cog1993
TthHC11_RS00235	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TthHC11_RS00250	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TthHC11_RS00260	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TthHC11_RS00265	COG1335	isochorismatase
TthHC11_RS00270	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TthHC11_RS00285	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TthHC11_RS00290	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TthHC11_RS00305	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TthHC11_RS00310	COG1660	Displays ATPase and GTPase activities
TthHC11_RS00315	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TthHC11_RS00360	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TthHC11_RS00360	COG1845	cytochrome c oxidase, subunit III
TthHC11_RS00365	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TthHC11_RS00365	COG2010	Cytochrome c
TthHC11_RS00370	COG1612	heme a metabolic process
TthHC11_RS00370	COG0109	protoheme IX farnesyltransferase activity
TthHC11_RS00385	COG0343	queuine tRNA-ribosyltransferase activity
TthHC11_RS00390	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TthHC11_RS00395	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TthHC11_RS00420	COG1940	carbohydrate kinase activity
TthHC11_RS00430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthHC11_RS00435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthHC11_RS00440	COG0589	response to stress
TthHC11_RS00445	COG1611	Belongs to the LOG family
TthHC11_RS00455	COG1011	Hydrolase
TthHC11_RS00460	COG0632	four-way junction helicase activity
TthHC11_RS00465	COG1024	Enoyl-CoA hydratase
TthHC11_RS00475	COG0508	dehydrogenase complex catalyzes the overall conversion of
TthHC11_RS00495	COG0137	argininosuccinate synthase activity
TthHC11_RS00500	COG0165	Argininosuccinate lyase
TthHC11_RS00520	COG0505	Belongs to the CarA family
TthHC11_RS00530	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TthHC11_RS00535	COG0166	Belongs to the GPI family
TthHC11_RS00550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthHC11_RS00555	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TthHC11_RS00560	COG0459	protein refolding
TthHC11_RS00565	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TthHC11_RS00570	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TthHC11_RS00580	COG0778	Nitroreductase
TthHC11_RS00585	COG1388	LysM domain
TthHC11_RS00585	COG0791	NLP P60 protein
TthHC11_RS00595	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TthHC11_RS00605	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TthHC11_RS00610	COG0581	inorganic phosphate transmembrane transporter activity
TthHC11_RS00615	COG0573	inorganic phosphate transmembrane transporter activity
TthHC11_RS00620	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TthHC11_RS00625	COG0482	sulfurtransferase activity
TthHC11_RS00635	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TthHC11_RS00640	COG0735	belongs to the Fur family
TthHC11_RS00655	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TthHC11_RS00680	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TthHC11_RS00685	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TthHC11_RS00690	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TthHC11_RS00695	COG0250	Participates in transcription elongation, termination and antitermination
TthHC11_RS00705	COG0081	regulation of translation
TthHC11_RS00730	COG0629	single-stranded DNA binding
TthHC11_RS00735	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TthHC11_RS00740	COG0359	binds to the 23S rRNA
TthHC11_RS00750	COG0300	oxidoreductase activity
TthHC11_RS00755	COG0321	lipoyl(octanoyl) transferase activity
TthHC11_RS00760	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TthHC11_RS00785	COG1476	TRANSCRIPTIONal
TthHC11_RS00800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TthHC11_RS00815	COG1598	PFAM Uncharacterised protein family UPF0150
TthHC11_RS00820	COG0022	dehydrogenase e1 component
TthHC11_RS00825	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TthHC11_RS00830	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TthHC11_RS00855	COG2226	methyltransferase
TthHC11_RS00860	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TthHC11_RS00870	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TthHC11_RS00875	COG1187	pseudouridine synthase activity
TthHC11_RS00885	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TthHC11_RS00890	COG0686	Belongs to the AlaDH PNT family
TthHC11_RS00900	COG1461	Dihydroxyacetone kinase
TthHC11_RS00910	COG3583	domain protein
TthHC11_RS00910	COG3584	3D domain protein
TthHC11_RS00915	COG4591	ABC-type transport system involved in lipoprotein release permease component
TthHC11_RS00920	COG0222	ribosome binding
TthHC11_RS00925	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TthHC11_RS00935	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TthHC11_RS00950	COG0697	spore germination
TthHC11_RS00960	COG3177	Filamentation induced by cAMP protein fic
TthHC11_RS00970	COG0243	molybdopterin cofactor binding
TthHC11_RS00975	COG2272	Belongs to the type-B carboxylesterase lipase family
TthHC11_RS00980	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TthHC11_RS00990	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthHC11_RS01005	COG0477	Major facilitator Superfamily
TthHC11_RS01020	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TthHC11_RS01030	COG0105	UTP biosynthetic process
TthHC11_RS01035	COG0631	protein serine/threonine phosphatase activity
TthHC11_RS01040	COG0583	DNA-binding transcription factor activity
TthHC11_RS01050	COG0508	dehydrogenase complex catalyzes the overall conversion of
TthHC11_RS01085	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TthHC11_RS01095	COG1278	Cold shock
TthHC11_RS01100	COG0484	heat shock protein binding
TthHC11_RS01105	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TthHC11_RS01110	COG1968	undecaprenyl-diphosphatase activity
TthHC11_RS01115	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TthHC11_RS01120	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TthHC11_RS01140	COG1309	transcriptional regulator
TthHC11_RS01145	COG4242	Belongs to the peptidase S51 family
TthHC11_RS01160	COG0802	atpase or kinase
TthHC11_RS01170	COG0539	negative regulation of cytoplasmic translation
TthHC11_RS01175	COG0495	leucyl-tRNA aminoacylation
TthHC11_RS01200	COG1902	pentaerythritol trinitrate reductase activity
TthHC11_RS01225	COG2414	aldehyde ferredoxin oxidoreductase
TthHC11_RS01235	COG2165	general secretion pathway protein
TthHC11_RS01245	COG2165	general secretion pathway protein
TthHC11_RS01250	COG2165	general secretion pathway protein
TthHC11_RS01280	COG1459	type II secretion system
TthHC11_RS01290	COG1187	pseudouridine synthase activity
TthHC11_RS01300	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TthHC11_RS01305	COG0745	RESPONSE REGULATOR receiver
TthHC11_RS01310	COG4191	Histidine kinase
TthHC11_RS01315	COG0704	Plays a role in the regulation of phosphate uptake
TthHC11_RS01330	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TthHC11_RS01340	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TthHC11_RS01340	COG0515	serine threonine protein kinase
TthHC11_RS01365	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TthHC11_RS01370	COG1028	Short-chain dehydrogenase reductase Sdr
TthHC11_RS01385	COG0717	Belongs to the dCTP deaminase family
TthHC11_RS01390	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TthHC11_RS01395	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TthHC11_RS01400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthHC11_RS01410	COG0583	DNA-binding transcription factor activity
TthHC11_RS01415	COG3546	catalase activity
TthHC11_RS01435	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TthHC11_RS01450	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthHC11_RS01460	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TthHC11_RS01465	COG0442	prolyl-tRNA aminoacylation
TthHC11_RS01470	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TthHC11_RS01490	COG0303	'Molybdopterin
TthHC11_RS01495	COG0513	Belongs to the DEAD box helicase family
TthHC11_RS01520	COG4983	Phage plasmid primase, P4 family domain protein
TthHC11_RS01560	COG0582	viral genome integration into host DNA
TthHC11_RS01570	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TthHC11_RS01580	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TthHC11_RS01600	COG2070	2-Nitropropane dioxygenase
TthHC11_RS01615	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TthHC11_RS01620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthHC11_RS01625	COG0018	arginyl-trna synthetase
TthHC11_RS01630	COG1007	ATP synthesis coupled electron transport
TthHC11_RS01635	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthHC11_RS01640	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TthHC11_RS01645	COG0713	ATP synthesis coupled electron transport
TthHC11_RS01650	COG0839	Belongs to the complex I subunit 6 family
TthHC11_RS01655	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthHC11_RS01660	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TthHC11_RS01665	COG1034	ATP synthesis coupled electron transport
TthHC11_RS01670	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TthHC11_RS01675	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TthHC11_RS01680	COG0649	NAD binding
TthHC11_RS01685	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthHC11_RS01690	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthHC11_RS01695	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthHC11_RS01700	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TthHC11_RS01710	COG4712	double-strand break repair protein
TthHC11_RS01725	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TthHC11_RS01740	COG0135	phosphoribosylanthranilate isomerase activity
TthHC11_RS01745	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TthHC11_RS01745	COG1372	Participates in initiation and elongation during chromosome replication
TthHC11_RS01750	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TthHC11_RS01760	COG2720	vancomycin resistance protein
TthHC11_RS01765	COG1126	abc transporter atp-binding protein
TthHC11_RS01795	COG0277	FAD linked oxidase domain protein
TthHC11_RS01805	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TthHC11_RS01815	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TthHC11_RS01830	COG0314	molybdopterin synthase activity
TthHC11_RS01835	COG1420	regulation of RNA biosynthetic process
TthHC11_RS01840	COG0347	Belongs to the P(II) protein family
TthHC11_RS01845	COG0004	ammonium transporteR
TthHC11_RS01855	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TthHC11_RS01865	COG0123	including yeast histone deacetylase and acetoin utilization protein
TthHC11_RS01880	COG1597	lipid kinase activity
TthHC11_RS01885	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
TthHC11_RS01895	COG0436	Aminotransferase
TthHC11_RS01905	COG0475	glutathione-regulated potassium exporter activity
TthHC11_RS01905	COG0569	domain protein
TthHC11_RS01915	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TthHC11_RS01925	COG0277	FAD linked oxidase domain protein
TthHC11_RS01965	COG2002	toxin-antitoxin pair type II binding
TthHC11_RS01995	COG0667	Aldo Keto reductase
TthHC11_RS02015	COG2199	diguanylate cyclase activity
TthHC11_RS02025	COG1067	ATP-dependent peptidase activity
TthHC11_RS02030	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TthHC11_RS02045	COG2105	PFAM AIG2 family protein
TthHC11_RS02050	COG0297	glycogen (starch) synthase activity
TthHC11_RS02060	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TthHC11_RS02065	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TthHC11_RS02080	COG0142	geranyltranstransferase activity
TthHC11_RS02090	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TthHC11_RS02110	COG1028	Short-chain dehydrogenase reductase Sdr
TthHC11_RS02115	COG0492	ferredoxin-NADP+ reductase activity
TthHC11_RS02125	COG0792	nuclease activity
TthHC11_RS02130	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TthHC11_RS02145	COG1175	transmembrane transport
TthHC11_RS02150	COG0395	ABC-type sugar transport system, permease component
TthHC11_RS02190	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TthHC11_RS02195	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TthHC11_RS02200	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TthHC11_RS02205	COG0805	protein transport
TthHC11_RS02210	COG1605	Chorismate mutase
TthHC11_RS02210	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TthHC11_RS02265	COG1063	alcohol dehydrogenase
TthHC11_RS02295	COG2255	four-way junction helicase activity
TthHC11_RS02300	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TthHC11_RS02305	COG0564	pseudouridine synthase activity
TthHC11_RS02330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TthHC11_RS02335	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TthHC11_RS02340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TthHC11_RS02345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TthHC11_RS02355	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TthHC11_RS02360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TthHC11_RS02365	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TthHC11_RS02400	COG1028	Short-chain dehydrogenase reductase Sdr
TthHC11_RS02405	COG0778	Nitroreductase
TthHC11_RS02425	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TthHC11_RS02430	COG0131	Imidazoleglycerol-phosphate dehydratase
TthHC11_RS02435	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TthHC11_RS02440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TthHC11_RS02445	COG0517	IMP dehydrogenase activity
TthHC11_RS02445	COG0516	GMP reductase activity
TthHC11_RS02460	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TthHC11_RS02475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TthHC11_RS02490	COG2890	protein-(glutamine-N5) methyltransferase activity
TthHC11_RS02500	COG0706	membrane insertase activity
TthHC11_RS02505	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TthHC11_RS02510	COG0594	ribonuclease P activity
TthHC11_RS02515	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TthHC11_RS02525	COG1022	Amp-dependent synthetase and ligase
TthHC11_RS02550	COG1121	(ABC) transporter
TthHC11_RS02555	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TthHC11_RS02560	COG1959	2 iron, 2 sulfur cluster binding
TthHC11_RS02565	COG1104	cysteine desulfurase activity
TthHC11_RS02570	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TthHC11_RS02575	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TthHC11_RS02590	COG1028	Short-chain dehydrogenase reductase Sdr
TthHC11_RS02615	COG0492	ferredoxin-NADP+ reductase activity
TthHC11_RS02620	COG1028	Short-chain dehydrogenase reductase Sdr
TthHC11_RS02620	COG3321	synthase
TthHC11_RS02620	COG0604	alcohol dehydrogenase
TthHC11_RS02625	COG0747	negative chemotaxis
TthHC11_RS02630	COG0601	transmembrane transport
TthHC11_RS02635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthHC11_RS02650	COG0517	IMP dehydrogenase activity
TthHC11_RS02650	COG0617	tRNA 3'-terminal CCA addition
TthHC11_RS02650	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthHC11_RS02655	COG0123	including yeast histone deacetylase and acetoin utilization protein
TthHC11_RS02660	COG2104	thiamine diphosphate biosynthetic process
TthHC11_RS02665	COG0037	tRNA processing
TthHC11_RS02680	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
TthHC11_RS02690	COG0366	Alpha amylase catalytic
TthHC11_RS02695	COG2226	methyltransferase
TthHC11_RS02700	COG2226	methyltransferase
TthHC11_RS02710	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TthHC11_RS02720	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TthHC11_RS02725	COG3744	PilT protein domain protein
TthHC11_RS02745	COG0460	homoserine dehydrogenase
TthHC11_RS02755	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TthHC11_RS02800	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TthHC11_RS02820	COG0247	lactate metabolic process
TthHC11_RS02825	COG0277	FAD linked oxidase domain protein
TthHC11_RS02830	COG0277	FAD linked oxidase domain protein
TthHC11_RS02835	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TthHC11_RS02840	COG1414	Transcriptional regulator
TthHC11_RS02845	COG0789	Transcriptional regulator
TthHC11_RS02855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthHC11_RS02860	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TthHC11_RS02895	COG0861	Integral membrane protein TerC family
TthHC11_RS02900	COG2151	metal-sulfur cluster biosynthetic enzyme
TthHC11_RS02905	COG0281	malic enzyme
TthHC11_RS02920	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TthHC11_RS02925	COG0509	glycine decarboxylation via glycine cleavage system
TthHC11_RS02930	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TthHC11_RS02935	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TthHC11_RS02940	COG0196	riboflavin kinase activity
TthHC11_RS02965	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TthHC11_RS02970	COG2813	Specifically methylates the guanine in position
TthHC11_RS03005	COG4956	integral membrane protein (PIN domain superfamily)
TthHC11_RS03010	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TthHC11_RS03015	COG0542	response to heat
TthHC11_RS03020	COG0423	glycine-tRNA ligase activity
TthHC11_RS03035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TthHC11_RS03055	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthHC11_RS03055	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TthHC11_RS03065	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TthHC11_RS03075	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TthHC11_RS03085	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthHC11_RS03090	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TthHC11_RS03095	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TthHC11_RS03100	COG0114	fumarate hydratase activity
TthHC11_RS03105	COG0183	Belongs to the thiolase family
TthHC11_RS03120	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TthHC11_RS03125	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TthHC11_RS03140	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TthHC11_RS03145	COG1254	Belongs to the acylphosphatase family
TthHC11_RS03155	COG1063	alcohol dehydrogenase
TthHC11_RS03160	COG2133	pyrroloquinoline quinone binding
TthHC11_RS03170	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TthHC11_RS03175	COG0154	amidase activity
TthHC11_RS03200	COG0572	uridine kinase
TthHC11_RS03205	COG3842	ATPase activity
TthHC11_RS03220	COG4475	Protein of unknown function (DUF436)
TthHC11_RS03275	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthHC11_RS03280	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TthHC11_RS03285	COG0803	Belongs to the bacterial solute-binding protein 9 family
TthHC11_RS03300	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TthHC11_RS03305	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TthHC11_RS03310	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TthHC11_RS03315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TthHC11_RS03325	COG1028	Short-chain dehydrogenase reductase Sdr
TthHC11_RS03330	COG0318	PFAM AMP-dependent synthetase and ligase
TthHC11_RS03345	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TthHC11_RS03350	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TthHC11_RS03355	COG1293	RNA-binding protein homologous to eukaryotic snRNP
TthHC11_RS03360	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TthHC11_RS03370	COG3870	Protein conserved in bacteria
TthHC11_RS03375	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TthHC11_RS03395	COG0544	peptidyl-prolyl cis-trans isomerase activity
TthHC11_RS03400	COG0740	serine-type endopeptidase activity
TthHC11_RS03405	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TthHC11_RS03410	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TthHC11_RS03415	COG0646	methionine synthase
TthHC11_RS03415	COG1410	methionine synthase
TthHC11_RS03425	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TthHC11_RS03450	COG1692	metallophosphoesterase
TthHC11_RS03455	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TthHC11_RS03460	COG1970	mechanosensitive ion channel activity
TthHC11_RS03525	COG2189	Belongs to the N(4) N(6)-methyltransferase family
TthHC11_RS03535	COG0582	viral genome integration into host DNA
TthHC11_RS03555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TthHC11_RS03565	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TthHC11_RS03570	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TthHC11_RS03615	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TthHC11_RS03635	COG0438	transferase activity, transferring glycosyl groups
TthHC11_RS03650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TthHC11_RS03670	COG0489	protein tyrosine kinase activity
TthHC11_RS03680	COG2264	protein methyltransferase activity
TthHC11_RS03685	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TthHC11_RS03720	COG0574	Belongs to the PEP-utilizing enzyme family
TthHC11_RS03720	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TthHC11_RS03730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TthHC11_RS03735	COG2046	Belongs to the sulfate adenylyltransferase family
TthHC11_RS03745	COG0730	response to heat
TthHC11_RS03750	COG0175	sulfate reduction
TthHC11_RS03755	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthHC11_RS03755	COG1648	precorrin-2 dehydrogenase activity
TthHC11_RS03760	COG1587	Uroporphyrinogen-III synthase
TthHC11_RS03765	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TthHC11_RS03775	COG0352	thiamine-phosphate diphosphorylase activity
TthHC11_RS03780	COG2104	thiamine diphosphate biosynthetic process
TthHC11_RS03785	COG2022	thiamine diphosphate biosynthetic process
TthHC11_RS03790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthHC11_RS03790	COG2022	thiamine diphosphate biosynthetic process
TthHC11_RS03795	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TthHC11_RS03800	COG0477	Major facilitator Superfamily
TthHC11_RS03805	COG0351	phosphomethylpyrimidine kinase
TthHC11_RS03835	COG1175	transmembrane transport
TthHC11_RS03845	COG1940	carbohydrate kinase activity
TthHC11_RS03850	COG0183	Belongs to the thiolase family
TthHC11_RS03870	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TthHC11_RS03870	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TthHC11_RS03880	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TthHC11_RS03890	COG0195	Participates in both transcription termination and antitermination
TthHC11_RS03895	COG0779	Required for maturation of 30S ribosomal subunits
TthHC11_RS03905	COG0739	heme binding
TthHC11_RS03910	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TthHC11_RS03915	COG0640	Transcriptional regulator
TthHC11_RS03920	COG2217	Heavy metal translocating P-type atpase
TthHC11_RS03925	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TthHC11_RS03930	COG0017	Asparaginyl-tRNA synthetase
TthHC11_RS03935	COG0561	phosphatase activity
TthHC11_RS03940	COG0384	phenazine biosynthesis protein PhzF
TthHC11_RS03950	COG0124	histidyl-tRNA synthetase
TthHC11_RS03960	COG3842	ATPase activity
TthHC11_RS03975	COG1573	uracil-dna glycosylase
TthHC11_RS03995	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TthHC11_RS04000	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TthHC11_RS04000	COG0519	Catalyzes the synthesis of GMP from XMP
TthHC11_RS04010	COG1316	TRANSCRIPTIONal
TthHC11_RS04020	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TthHC11_RS04065	COG0295	cytidine deaminase activity
TthHC11_RS04075	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TthHC11_RS04085	COG1760	l-serine dehydratase
TthHC11_RS04095	COG0481	GTPase activity
TthHC11_RS04105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TthHC11_RS04120	COG1028	Short-chain dehydrogenase reductase Sdr
TthHC11_RS04175	COG3706	GGDEF domain
TthHC11_RS04180	COG0405	Gamma-glutamyltransferase
TthHC11_RS04185	COG1073	alpha beta
TthHC11_RS04200	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TthHC11_RS04205	COG2873	o-acetylhomoserine
TthHC11_RS04220	COG1063	alcohol dehydrogenase
TthHC11_RS04235	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthHC11_RS04245	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TthHC11_RS04250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthHC11_RS04255	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TthHC11_RS04260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TthHC11_RS04270	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TthHC11_RS04280	COG0167	dihydroorotate dehydrogenase activity
TthHC11_RS04290	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TthHC11_RS04295	COG0540	Belongs to the ATCase OTCase family
TthHC11_RS04300	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TthHC11_RS04310	COG0730	response to heat
TthHC11_RS04315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TthHC11_RS04325	COG0312	modulator of DNA gyrase
TthHC11_RS04335	COG1960	acyl-CoA dehydrogenase activity
TthHC11_RS04340	COG0456	acetyltransferase
TthHC11_RS04350	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TthHC11_RS04355	COG0009	L-threonylcarbamoyladenylate synthase
TthHC11_RS04360	COG1459	type II secretion system
TthHC11_RS04375	COG0277	FAD linked oxidase domain protein
TthHC11_RS04385	COG0287	Prephenate dehydrogenase
TthHC11_RS04390	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TthHC11_RS04395	COG2514	catechol 2,3-dioxygenase activity
TthHC11_RS04400	COG2353	YceI-like domain
TthHC11_RS04405	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TthHC11_RS04410	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TthHC11_RS04430	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthHC11_RS04435	COG0179	Fumarylacetoacetate (FAA) hydrolase
TthHC11_RS04445	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TthHC11_RS04450	COG0151	Belongs to the GarS family
TthHC11_RS04455	COG2176	DNA-directed DNA polymerase activity
TthHC11_RS04455	COG5002	protein histidine kinase activity
TthHC11_RS04485	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TthHC11_RS04495	COG0217	transcriptional regulatory protein
TthHC11_RS04500	COG4651	solute:proton antiporter activity
TthHC11_RS04500	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TthHC11_RS04505	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TthHC11_RS04510	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TthHC11_RS04515	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TthHC11_RS04520	COG1674	ftsk spoiiie
TthHC11_RS04535	COG0517	IMP dehydrogenase activity
TthHC11_RS04550	COG0617	tRNA 3'-terminal CCA addition
TthHC11_RS04550	COG3620	sequence-specific DNA binding
TthHC11_RS04550	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthHC11_RS04560	COG1994	Peptidase M50
TthHC11_RS04565	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TthHC11_RS04575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TthHC11_RS04590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TthHC11_RS04600	COG2719	SpoVR family
TthHC11_RS04605	COG2718	Belongs to the UPF0229 family
TthHC11_RS04610	COG2766	serine protein kinase
TthHC11_RS04635	COG2137	regulation of response to DNA damage stimulus
TthHC11_RS04645	COG2359	stage V sporulation protein S
TthHC11_RS04650	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TthHC11_RS04655	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TthHC11_RS04670	COG0750	zinc metalloprotease
TthHC11_RS04675	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TthHC11_RS04680	COG4589	Belongs to the CDS family
TthHC11_RS04685	COG0233	cytoplasmic translational termination
TthHC11_RS04690	COG0528	UMP kinase activity
TthHC11_RS04695	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TthHC11_RS04700	COG0052	Belongs to the universal ribosomal protein uS2 family
TthHC11_RS04725	COG0739	heme binding
TthHC11_RS04785	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TthHC11_RS04790	COG0494	nUDIX hydrolase
TthHC11_RS04820	COG0402	S-adenosylhomocysteine deaminase activity
TthHC11_RS04830	COG4948	Mandelate Racemase Muconate Lactonizing
TthHC11_RS04835	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TthHC11_RS04840	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthHC11_RS04845	COG1811	Na channel or pump
TthHC11_RS04850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthHC11_RS04850	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TthHC11_RS04865	COG1215	transferase activity, transferring glycosyl groups
TthHC11_RS04875	COG1215	transferase activity, transferring glycosyl groups
TthHC11_RS04885	COG0438	transferase activity, transferring glycosyl groups
TthHC11_RS04890	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TthHC11_RS04905	COG1012	belongs to the aldehyde dehydrogenase family
TthHC11_RS04910	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TthHC11_RS04915	COG1063	alcohol dehydrogenase
TthHC11_RS04930	COG0318	PFAM AMP-dependent synthetase and ligase
TthHC11_RS04945	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TthHC11_RS04955	COG1024	Enoyl-CoA hydratase
TthHC11_RS04955	COG1250	3-hydroxyacyl-CoA dehydrogenase
TthHC11_RS04960	COG0183	Belongs to the thiolase family
TthHC11_RS04965	COG1960	acyl-CoA dehydrogenase activity
TthHC11_RS04970	COG0215	cysteine-tRNA ligase activity
TthHC11_RS04975	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TthHC11_RS04985	COG2738	Putative neutral zinc metallopeptidase
TthHC11_RS05000	COG1196	nuclear chromosome segregation
TthHC11_RS05015	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TthHC11_RS05020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TthHC11_RS05020	COG3153	acetyltransferase
TthHC11_RS05025	COG1268	BioY protein
TthHC11_RS05035	COG0126	phosphoglycerate kinase activity
TthHC11_RS05040	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TthHC11_RS05045	COG0824	Thioesterase
TthHC11_RS05055	COG0557	exoribonuclease II activity
TthHC11_RS05070	COG1355	regulation of microtubule-based process
TthHC11_RS05075	COG0617	tRNA 3'-terminal CCA addition
TthHC11_RS05075	COG1353	crispr-associated protein
TthHC11_RS05080	COG0237	dephospho-CoA kinase activity
TthHC11_RS05095	COG0742	ribosomal rna small subunit methyltransferase
TthHC11_RS05100	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TthHC11_RS05105	COG0138	bifunctional purine biosynthesis protein purh
TthHC11_RS05110	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TthHC11_RS05125	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TthHC11_RS05195	COG0149	triose-phosphate isomerase activity
TthHC11_RS05200	COG3239	Fatty acid desaturase
TthHC11_RS05205	COG1490	D-aminoacyl-tRNA deacylase activity
TthHC11_RS05210	COG1307	EDD domain protein, DegV family
TthHC11_RS05215	COG1307	EDD domain protein, DegV family
TthHC11_RS05220	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TthHC11_RS05235	COG3769	mannosylglycerate metabolic process
TthHC11_RS05245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TthHC11_RS05255	COG1012	belongs to the aldehyde dehydrogenase family
TthHC11_RS05260	COG2368	4-hydroxyphenylacetate
TthHC11_RS05265	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TthHC11_RS05295	COG2050	protein possibly involved in aromatic compounds catabolism
TthHC11_RS05300	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TthHC11_RS05310	COG2030	dehydratase
TthHC11_RS05310	COG1012	belongs to the aldehyde dehydrogenase family
TthHC11_RS05330	COG3396	Phenylacetate-CoA oxygenase
TthHC11_RS05340	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TthHC11_RS05350	COG0395	ABC-type sugar transport system, permease component
TthHC11_RS05370	COG1980	fructose-bisphosphate aldolase activity
TthHC11_RS05375	COG1733	regulation of RNA biosynthetic process
TthHC11_RS05385	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TthHC11_RS05390	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TthHC11_RS05400	COG1331	Highly conserved protein containing a thioredoxin domain
TthHC11_RS05405	COG0183	Belongs to the thiolase family
TthHC11_RS05410	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TthHC11_RS05415	COG0477	Major facilitator Superfamily
TthHC11_RS05420	COG1846	Transcriptional regulator
TthHC11_RS05460	COG0745	RESPONSE REGULATOR receiver
TthHC11_RS05465	COG1012	belongs to the aldehyde dehydrogenase family
TthHC11_RS05475	COG0248	Ppx GppA phosphatase
TthHC11_RS05480	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TthHC11_RS05485	COG0210	DNA helicase
TthHC11_RS05505	COG0745	RESPONSE REGULATOR receiver
TthHC11_RS05510	COG2205	protein histidine kinase activity
TthHC11_RS05540	COG1136	(ABC) transporter
TthHC11_RS05545	COG0577	efflux transmembrane transporter activity
TthHC11_RS05545	COG1136	(ABC) transporter
TthHC11_RS05590	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthHC11_RS05610	COG0582	viral genome integration into host DNA
TthHC11_RS05620	COG2897	thiosulfate sulfurtransferase activity
TthHC11_RS05625	COG1760	l-serine dehydratase
TthHC11_RS05630	COG2197	response regulator
TthHC11_RS05635	COG0335	large ribosomal subunit rRNA binding
TthHC11_RS05640	COG0336	Belongs to the RNA methyltransferase TrmD family
TthHC11_RS05645	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TthHC11_RS05650	COG1837	Belongs to the UPF0109 family
TthHC11_RS05655	COG0228	four-way junction DNA binding
TthHC11_RS05670	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthHC11_RS05675	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthHC11_RS05675	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthHC11_RS05680	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TthHC11_RS05690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TthHC11_RS05700	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TthHC11_RS05705	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TthHC11_RS05710	COG1702	phosphate starvation-inducible protein PhoH
TthHC11_RS05720	COG4864	UPF0365 protein
TthHC11_RS05730	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TthHC11_RS05750	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthHC11_RS05750	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthHC11_RS05755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TthHC11_RS05765	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TthHC11_RS05770	COG1397	ADP-ribosylglycohydrolase
TthHC11_RS05775	COG2239	Acts as a magnesium transporter
TthHC11_RS05785	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TthHC11_RS05785	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TthHC11_RS05795	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TthHC11_RS05795	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TthHC11_RS05800	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TthHC11_RS05805	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TthHC11_RS05810	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TthHC11_RS05815	COG0006	proline dipeptidase activity
TthHC11_RS05825	COG0739	heme binding
TthHC11_RS05835	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TthHC11_RS05840	COG0254	rRNA binding
TthHC11_RS05855	COG2001	Belongs to the MraZ family
TthHC11_RS05860	COG0275	rRNA processing
TthHC11_RS05870	COG0768	penicillin binding
TthHC11_RS05875	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TthHC11_RS05885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TthHC11_RS05890	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TthHC11_RS05895	COG0772	Belongs to the SEDS family
TthHC11_RS05900	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TthHC11_RS05905	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TthHC11_RS05910	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TthHC11_RS05930	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TthHC11_RS05940	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TthHC11_RS05950	COG0159	tryptophan synthase activity
TthHC11_RS05955	COG0133	tryptophan synthase activity
TthHC11_RS05960	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TthHC11_RS05965	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TthHC11_RS05970	COG1744	ABC transporter substrate-binding protein PnrA-like
TthHC11_RS05975	COG3845	ABC transporter
TthHC11_RS06025	COG0438	transferase activity, transferring glycosyl groups
TthHC11_RS06030	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TthHC11_RS06040	COG0039	L-malate dehydrogenase activity
TthHC11_RS06045	COG2819	hydrolase of the alpha beta superfamily
TthHC11_RS06060	COG2181	nitrate reductase activity
TthHC11_RS06060	COG0247	lactate metabolic process
TthHC11_RS06070	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TthHC11_RS06075	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TthHC11_RS06080	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TthHC11_RS06090	COG0439	Biotin carboxylase
TthHC11_RS06095	COG0511	ligase activity, forming carbon-carbon bonds
TthHC11_RS06100	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TthHC11_RS06115	COG0010	Belongs to the arginase family
TthHC11_RS06130	COG1100	Small GTP-binding protein
TthHC11_RS06140	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TthHC11_RS06145	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TthHC11_RS06155	COG2814	Major facilitator Superfamily
TthHC11_RS06160	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TthHC11_RS06165	COG1185	polyribonucleotide nucleotidyltransferase activity
TthHC11_RS06170	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TthHC11_RS06180	COG0745	RESPONSE REGULATOR receiver
TthHC11_RS06185	COG5002	protein histidine kinase activity
TthHC11_RS06190	COG1960	acyl-CoA dehydrogenase activity
TthHC11_RS06195	COG2086	electron transfer activity
TthHC11_RS06200	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TthHC11_RS06210	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TthHC11_RS06215	COG1573	uracil-dna glycosylase
TthHC11_RS06220	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TthHC11_RS06220	COG1796	DNA polymerase
TthHC11_RS06230	COG2309	aminopeptidase activity
TthHC11_RS06250	COG2873	o-acetylhomoserine
TthHC11_RS06255	COG2358	TRAP transporter, solute receptor (TAXI family
TthHC11_RS06265	COG1126	abc transporter atp-binding protein
TthHC11_RS06275	COG1752	Esterase of the alpha-beta hydrolase superfamily
TthHC11_RS06280	COG3311	Transcriptional regulator
TthHC11_RS06290	COG0134	indole-3-glycerol-phosphate synthase activity
TthHC11_RS06295	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TthHC11_RS06305	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TthHC11_RS06320	COG0765	amino acid transport
TthHC11_RS06325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TthHC11_RS06335	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TthHC11_RS06340	COG0569	domain protein
TthHC11_RS06345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthHC11_RS06350	COG1426	Protein conserved in bacteria
TthHC11_RS06355	COG2313	pseudouridylate synthase activity
TthHC11_RS06365	COG3001	Fructosamine kinase
TthHC11_RS06370	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TthHC11_RS06380	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TthHC11_RS06405	COG0012	GTP binding
TthHC11_RS06410	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TthHC11_RS06420	COG0424	maF-like protein
TthHC11_RS06435	COG0768	penicillin binding
TthHC11_RS06440	COG0850	regulation of cytokinetic process
TthHC11_RS06445	COG2322	membrane
TthHC11_RS06465	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TthHC11_RS06470	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TthHC11_RS06480	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TthHC11_RS06495	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthHC11_RS06505	COG1131	(ABC) transporter
TthHC11_RS06520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TthHC11_RS06535	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TthHC11_RS06540	COG0440	acetolactate synthase activity
TthHC11_RS06545	COG0028	Belongs to the TPP enzyme family
TthHC11_RS06555	COG0492	ferredoxin-NADP+ reductase activity
TthHC11_RS06560	COG4970	Tfp pilus assembly protein FimT
TthHC11_RS06565	COG4970	Tfp pilus assembly protein FimT
TthHC11_RS06570	COG2165	general secretion pathway protein
TthHC11_RS06575	COG4966	pilus assembly protein PilW
TthHC11_RS06625	COG0180	Tryptophanyl-tRNA synthetase
TthHC11_RS06630	COG0544	peptidyl-prolyl cis-trans isomerase activity
TthHC11_RS06645	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TthHC11_RS06650	COG0066	3-isopropylmalate dehydratase activity
TthHC11_RS06655	COG0473	3-isopropylmalate dehydrogenase activity
TthHC11_RS06670	COG0300	oxidoreductase activity
TthHC11_RS06675	COG0129	dihydroxy-acid dehydratase activity
TthHC11_RS06685	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TthHC11_RS06690	COG1177	transmembrane transport
TthHC11_RS06695	COG1176	ABC-type spermidine putrescine transport system, permease component I
TthHC11_RS06700	COG3842	ATPase activity
TthHC11_RS06705	COG0772	Belongs to the SEDS family
TthHC11_RS06710	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TthHC11_RS06715	COG2894	cell division
TthHC11_RS06720	COG1733	regulation of RNA biosynthetic process
TthHC11_RS06730	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthHC11_RS06730	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthHC11_RS06740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthHC11_RS06745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthHC11_RS06750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthHC11_RS06755	COG0653	protein targeting
TthHC11_RS06760	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TthHC11_RS06780	COG0393	Putative heavy-metal-binding
TthHC11_RS06785	COG1111	helicase
TthHC11_RS06785	COG1205	dead DEAH box helicase
TthHC11_RS06800	COG0358	DNA primase activity
TthHC11_RS06810	COG1250	3-hydroxyacyl-CoA dehydrogenase
TthHC11_RS06815	COG0697	spore germination
TthHC11_RS06820	COG0612	Peptidase, M16
TthHC11_RS06825	COG0612	Peptidase, M16
TthHC11_RS06830	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TthHC11_RS06845	COG1394	ATPase activity, coupled to movement of substances
TthHC11_RS06850	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TthHC11_RS06855	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TthHC11_RS06860	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TthHC11_RS06865	COG1527	subunit (C
TthHC11_RS06870	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TthHC11_RS06880	COG1269	ATP hydrolysis coupled proton transport
TthHC11_RS06905	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TthHC11_RS06915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthHC11_RS06930	COG0419	ATPase involved in DNA repair
TthHC11_RS06935	COG0420	3'-5' exonuclease activity
TthHC11_RS06955	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TthHC11_RS06960	COG2884	Cell division ATP-binding protein ftsE
TthHC11_RS06965	COG0793	Belongs to the peptidase S41A family
TthHC11_RS06975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthHC11_RS06975	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthHC11_RS06980	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TthHC11_RS06985	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TthHC11_RS06995	COG1079	Belongs to the binding-protein-dependent transport system permease family
TthHC11_RS07000	COG4603	Belongs to the binding-protein-dependent transport system permease family
TthHC11_RS07005	COG1129	ABC transporter
TthHC11_RS07010	COG0746	molybdenum cofactor guanylyltransferase activity
TthHC11_RS07025	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthHC11_RS07045	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TthHC11_RS07050	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TthHC11_RS07055	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TthHC11_RS07065	COG0517	IMP dehydrogenase activity
TthHC11_RS07065	COG1994	Peptidase M50
TthHC11_RS07070	COG2358	TRAP transporter, solute receptor (TAXI family
TthHC11_RS07080	COG2358	TRAP transporter, solute receptor (TAXI family
TthHC11_RS07100	COG0788	formyltetrahydrofolate deformylase activity
TthHC11_RS07105	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TthHC11_RS07110	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TthHC11_RS07115	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TthHC11_RS07135	COG0737	Belongs to the 5'-nucleotidase family
TthHC11_RS07140	COG0174	glutamine synthetase
TthHC11_RS07150	COG0559	Belongs to the binding-protein-dependent transport system permease family
TthHC11_RS07170	COG0747	negative chemotaxis
TthHC11_RS07175	COG0601	transmembrane transport
TthHC11_RS07180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthHC11_RS07190	COG0285	dihydrofolate synthase activity
TthHC11_RS07195	COG1132	(ABC) transporter
TthHC11_RS07200	COG1132	(ABC) transporter
TthHC11_RS07205	COG0372	Belongs to the citrate synthase family
TthHC11_RS07210	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TthHC11_RS07215	COG1482	cell wall glycoprotein biosynthetic process
TthHC11_RS07225	COG1515	deoxyribonuclease V activity
TthHC11_RS07235	COG0776	regulation of translation
TthHC11_RS07250	COG2197	response regulator
TthHC11_RS07255	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TthHC11_RS07260	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TthHC11_RS07265	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TthHC11_RS07270	COG1324	tolerance protein
TthHC11_RS07285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthHC11_RS07305	COG2205	protein histidine kinase activity
TthHC11_RS07325	COG0247	lactate metabolic process
TthHC11_RS07330	COG1139	Iron-sulfur cluster binding protein
TthHC11_RS07335	COG1556	Lactate utilization protein
TthHC11_RS07345	COG1752	Esterase of the alpha-beta hydrolase superfamily
TthHC11_RS07350	COG2815	serine threonine protein kinase
TthHC11_RS07350	COG0515	serine threonine protein kinase
TthHC11_RS07360	COG0860	N-Acetylmuramoyl-L-alanine amidase
TthHC11_RS07370	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TthHC11_RS07400	COG0473	3-isopropylmalate dehydrogenase activity
TthHC11_RS07425	COG1450	Type ii and iii secretion system protein
TthHC11_RS07430	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TthHC11_RS07435	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TthHC11_RS07440	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TthHC11_RS07445	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TthHC11_RS07445	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TthHC11_RS07450	COG0736	holo-[acyl-carrier-protein] synthase activity
TthHC11_RS07465	COG1160	GTP binding
TthHC11_RS07470	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TthHC11_RS07475	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TthHC11_RS07475	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TthHC11_RS07480	COG0083	homoserine kinase activity
TthHC11_RS07495	COG0268	Binds directly to 16S ribosomal RNA
TthHC11_RS07505	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TthHC11_RS07510	COG0723	plastoquinol--plastocyanin reductase activity
TthHC11_RS07520	COG3088	subunit of a heme lyase
TthHC11_RS07520	COG4235	cytochrome complex assembly
TthHC11_RS07525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TthHC11_RS07530	COG1138	Cytochrome C-type biogenesis protein
TthHC11_RS07535	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TthHC11_RS07540	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TthHC11_RS07545	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TthHC11_RS07550	COG4133	protoheme IX ABC transporter activity
TthHC11_RS07555	COG0785	Cytochrome C biogenesis protein
TthHC11_RS07560	COG3258	Cytochrome c
TthHC11_RS07570	COG0446	pyridine nucleotide-disulphide oxidoreductase
TthHC11_RS07585	COG3258	Cytochrome c
TthHC11_RS07590	COG2010	Cytochrome c
TthHC11_RS07595	COG0737	Belongs to the 5'-nucleotidase family
TthHC11_RS07600	COG2010	Cytochrome c
TthHC11_RS07605	COG3258	Cytochrome c
TthHC11_RS07625	COG2010	Cytochrome c
TthHC11_RS07630	COG3842	ATPase activity
TthHC11_RS07660	COG0318	PFAM AMP-dependent synthetase and ligase
TthHC11_RS07665	COG3360	Dodecin
TthHC11_RS07680	COG1024	Enoyl-CoA hydratase
TthHC11_RS07685	COG0813	purine-nucleoside phosphorylase activity
TthHC11_RS07690	COG1136	(ABC) transporter
TthHC11_RS07695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthHC11_RS07700	COG2045	Belongs to the ComB family
TthHC11_RS07705	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TthHC11_RS07710	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TthHC11_RS07720	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TthHC11_RS07730	COG0107	imidazoleglycerol-phosphate synthase activity
TthHC11_RS07735	COG0140	phosphoribosyl-ATP diphosphatase activity
TthHC11_RS07735	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TthHC11_RS07740	COG1494	fructose-1,6-bisphosphatase
TthHC11_RS07745	COG0686	Belongs to the AlaDH PNT family
TthHC11_RS07750	COG0427	acetyl-CoA hydrolase
TthHC11_RS07755	COG0084	hydrolase, TatD family'
TthHC11_RS07760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TthHC11_RS07770	COG0017	Asparaginyl-tRNA synthetase
TthHC11_RS07775	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TthHC11_RS07790	COG2009	succinate dehydrogenase
TthHC11_RS07795	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TthHC11_RS07825	COG0318	PFAM AMP-dependent synthetase and ligase
TthHC11_RS07830	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TthHC11_RS07835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TthHC11_RS07840	COG0504	CTP synthase activity
TthHC11_RS07855	COG0070	glutamate synthase
TthHC11_RS07855	COG0069	glutamate synthase activity
TthHC11_RS07855	COG0067	glutamate synthase
TthHC11_RS07860	COG0840	transmembrane signaling receptor activity
TthHC11_RS07865	COG0305	Participates in initiation and elongation during chromosome replication
TthHC11_RS07870	COG0741	lytic transglycosylase activity
TthHC11_RS07875	COG0475	glutathione-regulated potassium exporter activity
TthHC11_RS07880	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthHC11_RS07880	COG0617	tRNA 3'-terminal CCA addition
TthHC11_RS07880	COG0517	IMP dehydrogenase activity
TthHC11_RS07895	COG0475	glutathione-regulated potassium exporter activity
TthHC11_RS07900	COG0490	domain, Protein
TthHC11_RS07920	COG3118	belongs to the thioredoxin family
TthHC11_RS07950	COG0542	response to heat
TthHC11_RS07955	COG0789	Transcriptional regulator
TthHC11_RS07960	COG0484	heat shock protein binding
TthHC11_RS07965	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TthHC11_RS07970	COG0443	Heat shock 70 kDa protein
TthHC11_RS07975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TthHC11_RS07980	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TthHC11_RS07985	COG0616	signal peptide processing
TthHC11_RS07990	COG1714	RDD family
TthHC11_RS08000	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
TthHC11_RS08005	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TthHC11_RS08010	COG0714	Associated with various cellular activities
TthHC11_RS08015	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TthHC11_RS08015	COG0574	Belongs to the PEP-utilizing enzyme family
TthHC11_RS08020	COG1272	protein, Hemolysin III
TthHC11_RS08030	COG3850	Histidine kinase
TthHC11_RS08030	COG5002	protein histidine kinase activity
TthHC11_RS08045	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TthHC11_RS08060	COG1011	Hydrolase
TthHC11_RS08080	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TthHC11_RS08090	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TthHC11_RS08100	COG0047	phosphoribosylformylglycinamidine synthase activity
TthHC11_RS08110	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TthHC11_RS08115	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TthHC11_RS08120	COG0116	Belongs to the methyltransferase superfamily
TthHC11_RS08135	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TthHC11_RS08140	COG0497	DNA recombination
TthHC11_RS08150	COG0604	alcohol dehydrogenase
TthHC11_RS08170	COG0585	pseudouridine synthase activity
TthHC11_RS08190	COG0557	exoribonuclease II activity
TthHC11_RS08195	COG0538	isocitrate dehydrogenase activity
TthHC11_RS08200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthHC11_RS08210	COG0037	tRNA processing
TthHC11_RS08210	COG0590	tRNA wobble adenosine to inosine editing
TthHC11_RS08225	COG2267	carboxylic ester hydrolase activity
TthHC11_RS08235	COG2050	protein possibly involved in aromatic compounds catabolism
TthHC11_RS08245	COG0322	excinuclease ABC activity
TthHC11_RS08250	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TthHC11_RS08255	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TthHC11_RS08260	COG1854	S-ribosylhomocysteine lyase activity
TthHC11_RS08265	COG0519	Catalyzes the synthesis of GMP from XMP
TthHC11_RS08265	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TthHC11_RS08275	COG4274	PFAM GYD family protein
TthHC11_RS08280	COG0346	lactoylglutathione lyase activity
TthHC11_RS08285	COG0328	RNA-DNA hybrid ribonuclease activity
TthHC11_RS08290	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TthHC11_RS08295	COG2095	MarC family integral membrane protein
TthHC11_RS08300	COG1438	arginine binding
TthHC11_RS08305	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TthHC11_RS08310	COG1758	RNA polymerase activity
TthHC11_RS08315	COG0194	GDP metabolic process
TthHC11_RS08325	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TthHC11_RS08330	COG2385	sporulation resulting in formation of a cellular spore
TthHC11_RS08335	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
TthHC11_RS08345	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TthHC11_RS08385	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TthHC11_RS08390	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TthHC11_RS08395	COG1012	belongs to the aldehyde dehydrogenase family
TthHC11_RS08400	COG0506	proline dehydrogenase activity
TthHC11_RS08415	COG0156	8-amino-7-oxononanoate synthase activity
TthHC11_RS08420	COG0732	type I restriction modification DNA specificity domain
TthHC11_RS08420	COG0827	DNA restriction-modification system
TthHC11_RS08435	COG0187	DNA topoisomerase II activity
TthHC11_RS08440	COG1181	Belongs to the D-alanine--D-alanine ligase family
TthHC11_RS08445	COG0193	aminoacyl-tRNA hydrolase activity
TthHC11_RS08450	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TthHC11_RS08475	COG2815	serine threonine protein kinase
TthHC11_RS08475	COG0515	serine threonine protein kinase
TthHC11_RS08480	COG0631	protein serine/threonine phosphatase activity
TthHC11_RS08495	COG0113	porphobilinogen synthase activity
TthHC11_RS08500	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TthHC11_RS08505	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TthHC11_RS08530	COG4946	Tricorn protease homolog
TthHC11_RS08530	COG0823	Involved in the tonB-independent uptake of proteins
TthHC11_RS08530	COG1506	peptidase
TthHC11_RS08535	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TthHC11_RS08540	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TthHC11_RS08560	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TthHC11_RS08565	COG1011	Hydrolase
TthHC11_RS08590	COG0537	adenosine 5'-monophosphoramidase activity
TthHC11_RS08595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthHC11_RS08600	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TthHC11_RS08605	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TthHC11_RS08610	COG0071	Belongs to the small heat shock protein (HSP20) family
TthHC11_RS08615	COG2897	thiosulfate sulfurtransferase activity
TthHC11_RS08620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TthHC11_RS08630	COG1764	response to oxidative stress
TthHC11_RS08645	COG1840	ABC-type Fe3 transport system, periplasmic component
TthHC11_RS08655	COG3842	ATPase activity
TthHC11_RS08660	COG0101	tRNA pseudouridine synthase activity
TthHC11_RS08665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthHC11_RS08670	COG0601	transmembrane transport
TthHC11_RS08695	COG0006	proline dipeptidase activity
TthHC11_RS08700	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TthHC11_RS08715	COG1166	arginine decarboxylase activity
TthHC11_RS08735	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TthHC11_RS08740	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TthHC11_RS08745	COG1611	Belongs to the LOG family
TthHC11_RS08750	COG1193	negative regulation of DNA recombination
TthHC11_RS08760	COG0366	Alpha amylase catalytic
TthHC11_RS08795	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TthHC11_RS08800	COG0142	geranyltranstransferase activity
TthHC11_RS08810	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TthHC11_RS08840	COG0203	ribosomal protein L17
TthHC11_RS08845	COG0202	RNA polymerase activity
TthHC11_RS08850	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TthHC11_RS08855	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TthHC11_RS08860	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TthHC11_RS08870	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TthHC11_RS08880	COG0563	adenylate kinase activity
TthHC11_RS08885	COG0201	protein transport
TthHC11_RS08910	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TthHC11_RS08915	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TthHC11_RS08920	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TthHC11_RS08945	COG0255	Belongs to the universal ribosomal protein uL29 family
TthHC11_RS08950	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TthHC11_RS08955	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TthHC11_RS08965	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TthHC11_RS08970	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TthHC11_RS08975	COG0089	rRNA binding
TthHC11_RS08980	COG0088	Forms part of the polypeptide exit tunnel
TthHC11_RS08990	COG0051	transcription antitermination factor activity, RNA binding
TthHC11_RS08995	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TthHC11_RS09005	COG0049	tRNA binding
TthHC11_RS09020	COG0442	prolyl-tRNA aminoacylation
TthHC11_RS09040	COG1115	amino acid carrier protein
TthHC11_RS09060	COG1489	DNA binding
TthHC11_RS09085	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TthHC11_RS09100	COG0432	Pfam Uncharacterised protein family UPF0047
TthHC11_RS09105	COG3253	May function as heme-dependent peroxidase
TthHC11_RS09110	COG0668	transmembrane transport
TthHC11_RS09120	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TthHC11_RS09125	COG2217	Heavy metal translocating P-type atpase
TthHC11_RS09145	COG0745	RESPONSE REGULATOR receiver
TthHC11_RS09150	COG2205	protein histidine kinase activity
TthHC11_RS09170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TthHC11_RS09175	COG2226	methyltransferase
TthHC11_RS09195	COG2132	Multicopper oxidase
TthHC11_RS09205	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TthHC11_RS09210	COG0822	iron-sulfur transferase activity
TthHC11_RS09230	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TthHC11_RS09240	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TthHC11_RS09245	COG0284	orotidine-5'-phosphate decarboxylase activity
TthHC11_RS09255	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TthHC11_RS09265	COG0416	fatty acid biosynthetic process
TthHC11_RS09270	COG3118	belongs to the thioredoxin family
TthHC11_RS09275	COG1185	polyribonucleotide nucleotidyltransferase activity
TthHC11_RS09280	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TthHC11_RS09290	COG0438	transferase activity, transferring glycosyl groups
TthHC11_RS09310	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TthHC11_RS09325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthHC11_RS09370	COG0437	4 iron, 4 sulfur cluster binding
TthHC11_RS09385	COG0825	malonyl-CoA metabolic process
TthHC11_RS09390	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TthHC11_RS09425	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TthHC11_RS09450	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TthHC11_RS09455	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TthHC11_RS09460	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TthHC11_RS09465	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TthHC11_RS09515	COG3328	transposase activity
TthHC11_RS09540	COG0315	cyclic pyranopterin monophosphate synthase activity
TthHC11_RS09550	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TthHC11_RS09565	COG1694	Mazg nucleotide pyrophosphohydrolase
TthHC11_RS09570	COG1803	Methylglyoxal synthase
TthHC11_RS09580	COG0301	tRNA thio-modification
TthHC11_RS09585	COG0154	amidase activity
TthHC11_RS09590	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TthHC11_RS09610	COG2154	pterin-4-alpha-carbinolamine dehydratase
TthHC11_RS09615	COG1607	acyl-coa hydrolase
TthHC11_RS09625	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TthHC11_RS09630	COG4149	molybdate abc transporter
TthHC11_RS09635	COG1840	ABC-type Fe3 transport system, periplasmic component
TthHC11_RS09650	COG0235	Class ii aldolase
TthHC11_RS09655	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TthHC11_RS09660	COG0085	RNA polymerase activity
TthHC11_RS09670	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TthHC11_RS09675	COG1077	Cell shape determining protein MreB Mrl
TthHC11_RS09680	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TthHC11_RS09680	COG1418	mRNA catabolic process
TthHC11_RS09685	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TthHC11_RS09690	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TthHC11_RS09695	COG1058	Belongs to the CinA family
TthHC11_RS09695	COG1546	Belongs to the CinA family
TthHC11_RS09700	COG0354	folic acid binding
TthHC11_RS09715	COG4948	Mandelate Racemase Muconate Lactonizing
TthHC11_RS09730	COG1175	transmembrane transport
TthHC11_RS09740	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TthHC11_RS09750	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TthHC11_RS09760	COG1136	(ABC) transporter
TthHC11_RS09760	COG0577	efflux transmembrane transporter activity
TthHC11_RS09765	COG4181	ATPase activity
TthHC11_RS09770	COG0446	pyridine nucleotide-disulphide oxidoreductase
TthHC11_RS09785	COG0396	ATPase activity
TthHC11_RS09790	COG0719	Fe-S assembly protein
TthHC11_RS09795	COG0719	Fe-S assembly protein
TthHC11_RS09800	COG2146	nitrite reductase [NAD(P)H] activity
TthHC11_RS09810	COG0512	Glutamine amidotransferase of anthranilate synthase
TthHC11_RS09815	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TthHC11_RS09855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TthHC11_RS09860	COG2226	methyltransferase
TthHC11_RS09865	COG4603	Belongs to the binding-protein-dependent transport system permease family
TthHC11_RS09870	COG1079	Belongs to the binding-protein-dependent transport system permease family
TthHC11_RS09885	COG1774	PSP1 C-terminal conserved region
TthHC11_RS09890	COG0470	DNA polymerase III
TthHC11_RS09925	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TthHC11_RS09930	COG0302	gtp cyclohydrolase
TthHC11_RS09960	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TthHC11_RS09970	COG0395	ABC-type sugar transport system, permease component
TthHC11_RS09985	COG1131	(ABC) transporter
TthHC11_RS10005	COG0556	nucleotide-excision repair
TthHC11_RS10015	COG0497	DNA recombination
TthHC11_RS10020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TthHC11_RS10030	COG0445	tRNA wobble uridine modification
TthHC11_RS10055	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TthHC11_RS10055	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TthHC11_RS10060	COG1543	Belongs to the glycosyl hydrolase 57 family
TthHC11_RS10065	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TthHC11_RS10070	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TthHC11_RS10085	COG0189	ligase activity
TthHC11_RS10100	COG0066	3-isopropylmalate dehydratase activity
TthHC11_RS10105	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TthHC11_RS10110	COG1598	PFAM Uncharacterised protein family UPF0150
TthHC11_RS10120	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TthHC11_RS10125	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TthHC11_RS10130	COG1960	acyl-CoA dehydrogenase activity
TthHC11_RS10135	COG0163	prenyltransferase activity
TthHC11_RS10180	COG4555	ABC transporter
TthHC11_RS10190	COG2096	Adenosyltransferase
TthHC11_RS10205	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TthHC11_RS10210	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TthHC11_RS10225	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TthHC11_RS10230	COG0723	plastoquinol--plastocyanin reductase activity
TthHC11_RS10240	COG2010	Cytochrome c
TthHC11_RS10260	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TthHC11_RS10265	COG1960	acyl-CoA dehydrogenase activity
TthHC11_RS10275	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TthHC11_RS10295	COG0393	Putative heavy-metal-binding
TthHC11_RS10305	COG3956	TIGRFAM MazG family protein
TthHC11_RS10315	COG0693	protein deglycase activity
TthHC11_RS10320	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TthHC11_RS10330	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TthHC11_RS10335	COG1937	Protein conserved in bacteria
TthHC11_RS10345	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TthHC11_RS10345	COG0674	pyruvate-flavodoxin oxidoreductase activity
TthHC11_RS10350	COG1013	pyruvate-flavodoxin oxidoreductase activity
TthHC11_RS10355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthHC11_RS10375	COG0205	6-phosphofructokinase activity
TthHC11_RS10380	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TthHC11_RS10390	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TthHC11_RS10405	COG2333	competence protein COMEC
TthHC11_RS10405	COG0658	competence protein
TthHC11_RS10410	COG1475	DNA binding
TthHC11_RS10415	COG1192	Involved in chromosome partitioning
TthHC11_RS10420	COG0357	Ribosomal RNA small subunit methyltransferase G
TthHC11_RS10425	COG0445	tRNA wobble uridine modification
TthHC11_RS10500	COG0411	ABC transporter
TthHC11_RS10505	COG0318	PFAM AMP-dependent synthetase and ligase
TthHC11_RS10530	COG1960	acyl-CoA dehydrogenase activity
TthHC11_RS10540	COG1028	Short-chain dehydrogenase reductase Sdr
TthHC11_RS10545	COG1012	belongs to the aldehyde dehydrogenase family
TthHC11_RS10545	COG2030	dehydratase
TthHC11_RS10555	COG0318	PFAM AMP-dependent synthetase and ligase
TthHC11_RS10560	COG1028	Short-chain dehydrogenase reductase Sdr
TthHC11_RS10580	COG0588	phosphoglycerate mutase activity
TthHC11_RS10735	COG2329	Antibiotic biosynthesis monooxygenase
TthHC11_RS10745	COG4558	Periplasmic binding protein
TthHC11_RS10750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TthHC11_RS10755	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TthHC11_RS10765	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TthHC11_RS10780	COG3706	GGDEF domain
TthHC11_RS10830	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TthHC11_RS10840	COG1607	acyl-coa hydrolase
TthHC11_RS10865	COG1403	HNH endonuclease
TthHC11_RS10875	COG4974	Belongs to the 'phage' integrase family
TthHC11_RS10905	COG2329	Antibiotic biosynthesis monooxygenase
TthHC11_RS10970	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TthHC11_RS10975	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TthHC11_RS11020	COG0514	ATP-dependent DNA helicase (RecQ)
TthHC11_RS11050	COG2414	aldehyde ferredoxin oxidoreductase
TthHC11_RS11155	COG2211	Major facilitator Superfamily
TthHC11_RS11190	COG2211	Major facilitator Superfamily
TthHC11_RS11225	COG1797	cobyrinic acid a,c-diamide synthase activity
TthHC11_RS11240	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TthHC11_RS11255	COG0588	phosphoglycerate mutase activity
TthHC11_RS11260	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
TthHC11_RS11265	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TthHC11_RS11310	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthHC11_RS11310	COG1648	precorrin-2 dehydrogenase activity
TthHC11_RS11315	COG0778	Nitroreductase
TthHC11_RS11335	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TthHC11_RS11345	COG1492	cobalamin metabolic process
TthHC11_RS11350	COG1785	Belongs to the alkaline phosphatase family
TthHC11_RS11380	COG1414	Transcriptional regulator
TthHC11_RS11385	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TthHC11_RS11395	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TthHC11_RS11400	COG1028	Short-chain dehydrogenase reductase Sdr
TthHC11_RS11415	COG1028	Short-chain dehydrogenase reductase Sdr
TthHC11_RS11430	COG1175	transmembrane transport
TthHC11_RS11440	COG2723	6-phospho-beta-galactosidase activity
TthHC11_RS11445	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TthHC11_RS11465	COG1233	COG1233 Phytoene dehydrogenase and related
TthHC11_RS11470	COG0702	epimerase
TthHC11_RS11510	COG1562	ergosterol biosynthetic process
TthHC11_RS11520	COG2124	cytochrome p450
TthHC11_RS11545	COG1487	ribonuclease activity
TthHC11_RS11555	COG1304	FMN binding
TthHC11_RS11575	COG1085	galactose-1-phosphate uridylyltransferase
TthHC11_RS11580	COG3345	alpha-galactosidase
TthHC11_RS11600	COG4966	pilus assembly protein PilW
TthHC11_RS11625	COG1475	DNA binding
TthHC11_RS11630	COG1192	Involved in chromosome partitioning
TthHC11_RS11675	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TthHC11_RS11730	COG2814	Major facilitator Superfamily
TthHC11_RS11740	COG0584	glycerophosphoryl diester phosphodiesterase
TthHC11_RS11750	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family