locus-tag	class	description
THTHE16_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THTHE16_RS00010	COG0592	DNA-directed DNA polymerase activity
THTHE16_RS00015	COG0148	phosphopyruvate hydratase activity
THTHE16_RS00020	COG0469	pyruvate kinase activity
THTHE16_RS00030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THTHE16_RS00035	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
THTHE16_RS00045	COG1842	Phage shock protein A
THTHE16_RS00075	COG0406	alpha-ribazole phosphatase activity
THTHE16_RS00080	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
THTHE16_RS00085	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THTHE16_RS00095	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THTHE16_RS00100	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
THTHE16_RS00105	COG1496	oxidoreductase activity
THTHE16_RS00110	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
THTHE16_RS00115	COG1278	Cold shock
THTHE16_RS00120	COG1653	transport
THTHE16_RS00135	COG0033	Phosphoglucomutase
THTHE16_RS00150	COG2814	Major facilitator Superfamily
THTHE16_RS00160	COG0517	IMP dehydrogenase activity
THTHE16_RS00160	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
THTHE16_RS00165	COG1950	PFAM Membrane protein of
THTHE16_RS00170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
THTHE16_RS00180	COG0181	hydroxymethylbilane synthase activity
THTHE16_RS00190	COG0285	dihydrofolate synthase activity
THTHE16_RS00195	COG0436	Aminotransferase
THTHE16_RS00200	COG0521	Mo-molybdopterin cofactor biosynthetic process
THTHE16_RS00225	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
THTHE16_RS00230	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THTHE16_RS00235	COG1993	acr, cog1993
THTHE16_RS00240	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
THTHE16_RS00250	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
THTHE16_RS00260	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
THTHE16_RS00265	COG1335	isochorismatase
THTHE16_RS00270	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THTHE16_RS00285	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
THTHE16_RS00290	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
THTHE16_RS00310	COG1660	Displays ATPase and GTPase activities
THTHE16_RS00315	COG0391	Required for morphogenesis under gluconeogenic growth conditions
THTHE16_RS00375	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
THTHE16_RS00375	COG1845	cytochrome c oxidase, subunit III
THTHE16_RS00380	COG2010	Cytochrome c
THTHE16_RS00380	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
THTHE16_RS00385	COG0109	protoheme IX farnesyltransferase activity
THTHE16_RS00385	COG1612	heme a metabolic process
THTHE16_RS00400	COG0343	queuine tRNA-ribosyltransferase activity
THTHE16_RS00405	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
THTHE16_RS00410	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
THTHE16_RS00465	COG1940	carbohydrate kinase activity
THTHE16_RS00475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
THTHE16_RS00485	COG0589	response to stress
THTHE16_RS00490	COG1611	Belongs to the LOG family
THTHE16_RS00500	COG1011	Hydrolase
THTHE16_RS00505	COG0632	four-way junction helicase activity
THTHE16_RS00510	COG1024	Enoyl-CoA hydratase
THTHE16_RS00520	COG0508	dehydrogenase complex catalyzes the overall conversion of
THTHE16_RS00530	COG0137	argininosuccinate synthase activity
THTHE16_RS00535	COG0165	Argininosuccinate lyase
THTHE16_RS00540	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
THTHE16_RS00540	COG0165	Argininosuccinate lyase
THTHE16_RS00555	COG0505	Belongs to the CarA family
THTHE16_RS00560	COG2759	Belongs to the formate--tetrahydrofolate ligase family
THTHE16_RS00570	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
THTHE16_RS00575	COG0166	Belongs to the GPI family
THTHE16_RS00585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THTHE16_RS00595	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THTHE16_RS00600	COG0459	protein refolding
THTHE16_RS00605	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
THTHE16_RS00610	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
THTHE16_RS00625	COG0791	NLP P60 protein
THTHE16_RS00625	COG1388	LysM domain
THTHE16_RS00635	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THTHE16_RS00645	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THTHE16_RS00650	COG0581	inorganic phosphate transmembrane transporter activity
THTHE16_RS00655	COG0573	inorganic phosphate transmembrane transporter activity
THTHE16_RS00660	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
THTHE16_RS00665	COG0482	sulfurtransferase activity
THTHE16_RS00675	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
THTHE16_RS00680	COG0735	belongs to the Fur family
THTHE16_RS00695	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
THTHE16_RS00720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THTHE16_RS00725	COG0267	Belongs to the bacterial ribosomal protein bL33 family
THTHE16_RS00730	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THTHE16_RS00735	COG0250	Participates in transcription elongation, termination and antitermination
THTHE16_RS00745	COG0081	regulation of translation
THTHE16_RS00760	COG0629	single-stranded DNA binding
THTHE16_RS00765	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
THTHE16_RS00770	COG0359	binds to the 23S rRNA
THTHE16_RS00780	COG0300	oxidoreductase activity
THTHE16_RS00785	COG0321	lipoyl(octanoyl) transferase activity
THTHE16_RS00790	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
THTHE16_RS00845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THTHE16_RS00855	COG1598	PFAM Uncharacterised protein family UPF0150
THTHE16_RS00860	COG0022	dehydrogenase e1 component
THTHE16_RS00865	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
THTHE16_RS00870	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
THTHE16_RS00895	COG2226	methyltransferase
THTHE16_RS00900	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
THTHE16_RS00910	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
THTHE16_RS00915	COG1187	pseudouridine synthase activity
THTHE16_RS00925	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
THTHE16_RS00940	COG1461	Dihydroxyacetone kinase
THTHE16_RS00955	COG4591	ABC-type transport system involved in lipoprotein release permease component
THTHE16_RS00960	COG0222	ribosome binding
THTHE16_RS00965	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
THTHE16_RS00975	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
THTHE16_RS00990	COG0697	spore germination
THTHE16_RS01000	COG3177	Filamentation induced by cAMP protein fic
THTHE16_RS01010	COG0243	molybdopterin cofactor binding
THTHE16_RS01015	COG2272	Belongs to the type-B carboxylesterase lipase family
THTHE16_RS01020	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
THTHE16_RS01030	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
THTHE16_RS01060	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
THTHE16_RS01070	COG0105	UTP biosynthetic process
THTHE16_RS01075	COG0631	protein serine/threonine phosphatase activity
THTHE16_RS01085	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
THTHE16_RS01115	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
THTHE16_RS01125	COG1278	Cold shock
THTHE16_RS01130	COG0484	heat shock protein binding
THTHE16_RS01135	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
THTHE16_RS01140	COG1968	undecaprenyl-diphosphatase activity
THTHE16_RS01145	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
THTHE16_RS01150	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
THTHE16_RS01165	COG1309	transcriptional regulator
THTHE16_RS01170	COG4242	Belongs to the peptidase S51 family
THTHE16_RS01185	COG0802	atpase or kinase
THTHE16_RS01195	COG0539	negative regulation of cytoplasmic translation
THTHE16_RS01200	COG0495	leucyl-tRNA aminoacylation
THTHE16_RS01215	COG1902	pentaerythritol trinitrate reductase activity
THTHE16_RS01225	COG2414	aldehyde ferredoxin oxidoreductase
THTHE16_RS01245	COG1187	pseudouridine synthase activity
THTHE16_RS01255	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
THTHE16_RS01260	COG0745	RESPONSE REGULATOR receiver
THTHE16_RS01265	COG4191	Histidine kinase
THTHE16_RS01270	COG0704	Plays a role in the regulation of phosphate uptake
THTHE16_RS01275	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
THTHE16_RS01285	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THTHE16_RS01295	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THTHE16_RS01295	COG0515	serine threonine protein kinase
THTHE16_RS01300	COG0251	oxidation-reduction process
THTHE16_RS01320	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THTHE16_RS01325	COG1028	Short-chain dehydrogenase reductase Sdr
THTHE16_RS01340	COG0717	Belongs to the dCTP deaminase family
THTHE16_RS01345	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
THTHE16_RS01350	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
THTHE16_RS01355	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
THTHE16_RS01360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THTHE16_RS01370	COG0583	DNA-binding transcription factor activity
THTHE16_RS01375	COG3546	catalase activity
THTHE16_RS01380	COG0758	DNA mediated transformation
THTHE16_RS01380	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THTHE16_RS01385	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
THTHE16_RS01400	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THTHE16_RS01410	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
THTHE16_RS01415	COG0442	prolyl-tRNA aminoacylation
THTHE16_RS01420	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
THTHE16_RS01440	COG0303	'Molybdopterin
THTHE16_RS01445	COG0513	Belongs to the DEAD box helicase family
THTHE16_RS01465	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
THTHE16_RS01485	COG2070	2-Nitropropane dioxygenase
THTHE16_RS01500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THTHE16_RS01505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THTHE16_RS01510	COG0018	arginyl-trna synthetase
THTHE16_RS01515	COG1007	ATP synthesis coupled electron transport
THTHE16_RS01520	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THTHE16_RS01525	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THTHE16_RS01530	COG0713	ATP synthesis coupled electron transport
THTHE16_RS01535	COG0839	Belongs to the complex I subunit 6 family
THTHE16_RS01540	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THTHE16_RS01545	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
THTHE16_RS01550	COG1034	ATP synthesis coupled electron transport
THTHE16_RS01555	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
THTHE16_RS01560	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
THTHE16_RS01565	COG0649	NAD binding
THTHE16_RS01570	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THTHE16_RS01575	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THTHE16_RS01580	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THTHE16_RS01585	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
THTHE16_RS01595	COG4712	double-strand break repair protein
THTHE16_RS01615	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
THTHE16_RS01630	COG0135	phosphoribosylanthranilate isomerase activity
THTHE16_RS01635	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THTHE16_RS01635	COG1372	Participates in initiation and elongation during chromosome replication
THTHE16_RS01640	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
THTHE16_RS01650	COG2720	vancomycin resistance protein
THTHE16_RS01655	COG1126	abc transporter atp-binding protein
THTHE16_RS01685	COG0277	FAD linked oxidase domain protein
THTHE16_RS01695	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THTHE16_RS01705	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
THTHE16_RS01720	COG0314	molybdopterin synthase activity
THTHE16_RS01725	COG1420	regulation of RNA biosynthetic process
THTHE16_RS01730	COG0347	Belongs to the P(II) protein family
THTHE16_RS01735	COG0004	ammonium transporteR
THTHE16_RS01745	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
THTHE16_RS01755	COG0123	including yeast histone deacetylase and acetoin utilization protein
THTHE16_RS01770	COG1597	lipid kinase activity
THTHE16_RS01785	COG0436	Aminotransferase
THTHE16_RS01795	COG0475	glutathione-regulated potassium exporter activity
THTHE16_RS01795	COG0569	domain protein
THTHE16_RS01800	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
THTHE16_RS01805	COG0227	Belongs to the bacterial ribosomal protein bL28 family
THTHE16_RS01815	COG0277	FAD linked oxidase domain protein
THTHE16_RS01825	COG3335	DDE superfamily endonuclease
THTHE16_RS01835	COG0667	Aldo Keto reductase
THTHE16_RS01860	COG1067	ATP-dependent peptidase activity
THTHE16_RS01865	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
THTHE16_RS01875	COG0745	RESPONSE REGULATOR receiver
THTHE16_RS01880	COG2105	PFAM AIG2 family protein
THTHE16_RS01885	COG0297	glycogen (starch) synthase activity
THTHE16_RS01895	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
THTHE16_RS01900	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
THTHE16_RS01915	COG0142	geranyltranstransferase activity
THTHE16_RS01925	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
THTHE16_RS01945	COG1028	Short-chain dehydrogenase reductase Sdr
THTHE16_RS01950	COG0492	ferredoxin-NADP+ reductase activity
THTHE16_RS01955	COG2815	serine threonine protein kinase
THTHE16_RS01955	COG0515	serine threonine protein kinase
THTHE16_RS01960	COG0792	nuclease activity
THTHE16_RS01965	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
THTHE16_RS01980	COG1175	transmembrane transport
THTHE16_RS01985	COG0395	ABC-type sugar transport system, permease component
THTHE16_RS02015	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
THTHE16_RS02020	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
THTHE16_RS02025	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THTHE16_RS02030	COG0805	protein transport
THTHE16_RS02035	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
THTHE16_RS02035	COG1605	Chorismate mutase
THTHE16_RS02090	COG1063	alcohol dehydrogenase
THTHE16_RS02120	COG2255	four-way junction helicase activity
THTHE16_RS02125	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
THTHE16_RS02130	COG0564	pseudouridine synthase activity
THTHE16_RS02145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
THTHE16_RS02150	COG0232	Belongs to the dGTPase family. Type 2 subfamily
THTHE16_RS02155	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THTHE16_RS02160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THTHE16_RS02170	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
THTHE16_RS02175	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THTHE16_RS02180	COG0333	Belongs to the bacterial ribosomal protein bL32 family
THTHE16_RS02215	COG1028	Short-chain dehydrogenase reductase Sdr
THTHE16_RS02220	COG0778	Nitroreductase
THTHE16_RS02235	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THTHE16_RS02240	COG0131	Imidazoleglycerol-phosphate dehydratase
THTHE16_RS02245	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
THTHE16_RS02250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THTHE16_RS02255	COG0516	GMP reductase activity
THTHE16_RS02255	COG0517	IMP dehydrogenase activity
THTHE16_RS02270	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
THTHE16_RS02285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THTHE16_RS02300	COG2890	protein-(glutamine-N5) methyltransferase activity
THTHE16_RS02310	COG0706	membrane insertase activity
THTHE16_RS02315	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
THTHE16_RS02320	COG0594	ribonuclease P activity
THTHE16_RS02325	COG0230	Belongs to the bacterial ribosomal protein bL34 family
THTHE16_RS02335	COG1022	Amp-dependent synthetase and ligase
THTHE16_RS02360	COG1121	(ABC) transporter
THTHE16_RS02365	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THTHE16_RS02370	COG1959	2 iron, 2 sulfur cluster binding
THTHE16_RS02375	COG1104	cysteine desulfurase activity
THTHE16_RS02380	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
THTHE16_RS02385	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
THTHE16_RS02390	COG1213	nucleotidyl transferase
THTHE16_RS02390	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THTHE16_RS02400	COG1028	Short-chain dehydrogenase reductase Sdr
THTHE16_RS02425	COG0492	ferredoxin-NADP+ reductase activity
THTHE16_RS02430	COG3321	synthase
THTHE16_RS02430	COG1028	Short-chain dehydrogenase reductase Sdr
THTHE16_RS02430	COG0604	alcohol dehydrogenase
THTHE16_RS02435	COG0747	negative chemotaxis
THTHE16_RS02440	COG0601	transmembrane transport
THTHE16_RS02445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THTHE16_RS02460	COG0517	IMP dehydrogenase activity
THTHE16_RS02465	COG0123	including yeast histone deacetylase and acetoin utilization protein
THTHE16_RS02470	COG2104	thiamine diphosphate biosynthetic process
THTHE16_RS02475	COG0037	tRNA processing
THTHE16_RS02490	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
THTHE16_RS02500	COG4176	ABC-type proline glycine betaine transport system permease component
THTHE16_RS02505	COG4175	Glycine betaine
THTHE16_RS02505	COG3448	diguanylate cyclase activity
THTHE16_RS02510	COG0366	Alpha amylase catalytic
THTHE16_RS02515	COG2226	methyltransferase
THTHE16_RS02520	COG2226	methyltransferase
THTHE16_RS02545	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
THTHE16_RS02550	COG3744	PilT protein domain protein
THTHE16_RS02560	COG0460	homoserine dehydrogenase
THTHE16_RS02570	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
THTHE16_RS02610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THTHE16_RS02635	COG0247	lactate metabolic process
THTHE16_RS02645	COG0277	FAD linked oxidase domain protein
THTHE16_RS02650	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
THTHE16_RS02655	COG1414	Transcriptional regulator
THTHE16_RS02660	COG0789	Transcriptional regulator
THTHE16_RS02670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THTHE16_RS02675	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
THTHE16_RS02710	COG0861	Integral membrane protein TerC family
THTHE16_RS02715	COG2151	metal-sulfur cluster biosynthetic enzyme
THTHE16_RS02720	COG0281	malic enzyme
THTHE16_RS02735	COG0404	The glycine cleavage system catalyzes the degradation of glycine
THTHE16_RS02740	COG0509	glycine decarboxylation via glycine cleavage system
THTHE16_RS02745	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THTHE16_RS02750	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THTHE16_RS02755	COG0196	riboflavin kinase activity
THTHE16_RS02765	COG1228	amidohydrolase
THTHE16_RS02780	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THTHE16_RS02785	COG2813	Specifically methylates the guanine in position
THTHE16_RS02790	COG0527	aspartate kinase activity
THTHE16_RS02820	COG4956	integral membrane protein (PIN domain superfamily)
THTHE16_RS02825	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
THTHE16_RS02830	COG0542	response to heat
THTHE16_RS02835	COG0423	glycine-tRNA ligase activity
THTHE16_RS02850	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
THTHE16_RS02870	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THTHE16_RS02870	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THTHE16_RS02880	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
THTHE16_RS02890	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
THTHE16_RS02900	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THTHE16_RS02905	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
THTHE16_RS02910	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
THTHE16_RS02915	COG0114	fumarate hydratase activity
THTHE16_RS02920	COG0183	Belongs to the thiolase family
THTHE16_RS02930	COG3335	DDE superfamily endonuclease
THTHE16_RS02945	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
THTHE16_RS02950	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
THTHE16_RS02965	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
THTHE16_RS02970	COG1254	Belongs to the acylphosphatase family
THTHE16_RS02980	COG1063	alcohol dehydrogenase
THTHE16_RS02985	COG2133	pyrroloquinoline quinone binding
THTHE16_RS02995	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
THTHE16_RS03000	COG0154	amidase activity
THTHE16_RS03025	COG0572	uridine kinase
THTHE16_RS03030	COG3842	ATPase activity
THTHE16_RS03045	COG4475	Protein of unknown function (DUF436)
THTHE16_RS03100	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
THTHE16_RS03105	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
THTHE16_RS03110	COG0803	Belongs to the bacterial solute-binding protein 9 family
THTHE16_RS03125	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
THTHE16_RS03130	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
THTHE16_RS03135	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
THTHE16_RS03160	COG0318	PFAM AMP-dependent synthetase and ligase
THTHE16_RS03165	COG1012	belongs to the aldehyde dehydrogenase family
THTHE16_RS03165	COG2030	dehydratase
THTHE16_RS03170	COG1960	acyl-CoA dehydrogenase activity
THTHE16_RS03185	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
THTHE16_RS03190	COG1293	RNA-binding protein homologous to eukaryotic snRNP
THTHE16_RS03195	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
THTHE16_RS03205	COG3870	Protein conserved in bacteria
THTHE16_RS03210	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
THTHE16_RS03230	COG0544	peptidyl-prolyl cis-trans isomerase activity
THTHE16_RS03235	COG0740	serine-type endopeptidase activity
THTHE16_RS03240	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
THTHE16_RS03245	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
THTHE16_RS03250	COG0646	methionine synthase
THTHE16_RS03250	COG1410	methionine synthase
THTHE16_RS03255	COG0512	Glutamine amidotransferase of anthranilate synthase
THTHE16_RS03255	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
THTHE16_RS03280	COG1692	metallophosphoesterase
THTHE16_RS03285	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
THTHE16_RS03290	COG1970	mechanosensitive ion channel activity
THTHE16_RS03310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THTHE16_RS03320	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
THTHE16_RS03325	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
THTHE16_RS03370	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
THTHE16_RS03380	COG1215	transferase activity, transferring glycosyl groups
THTHE16_RS03395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THTHE16_RS03415	COG0489	protein tyrosine kinase activity
THTHE16_RS03425	COG2264	protein methyltransferase activity
THTHE16_RS03430	COG1385	rRNA (uridine-N3-)-methyltransferase activity
THTHE16_RS03470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
THTHE16_RS03475	COG2046	Belongs to the sulfate adenylyltransferase family
THTHE16_RS03480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
THTHE16_RS03480	COG1648	precorrin-2 dehydrogenase activity
THTHE16_RS03485	COG0730	response to heat
THTHE16_RS03490	COG0175	sulfate reduction
THTHE16_RS03495	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
THTHE16_RS03495	COG1648	precorrin-2 dehydrogenase activity
THTHE16_RS03500	COG1587	Uroporphyrinogen-III synthase
THTHE16_RS03505	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THTHE16_RS03515	COG0352	thiamine-phosphate diphosphorylase activity
THTHE16_RS03520	COG2104	thiamine diphosphate biosynthetic process
THTHE16_RS03525	COG2022	thiamine diphosphate biosynthetic process
THTHE16_RS03530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THTHE16_RS03530	COG2022	thiamine diphosphate biosynthetic process
THTHE16_RS03535	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
THTHE16_RS03540	COG0477	Major facilitator Superfamily
THTHE16_RS03545	COG0352	thiamine-phosphate diphosphorylase activity
THTHE16_RS03545	COG0351	phosphomethylpyrimidine kinase
THTHE16_RS03575	COG1175	transmembrane transport
THTHE16_RS03585	COG1940	carbohydrate kinase activity
THTHE16_RS03590	COG0183	Belongs to the thiolase family
THTHE16_RS03600	COG1804	L-carnitine dehydratase bile acid-inducible protein F
THTHE16_RS03605	COG1028	Short-chain dehydrogenase reductase Sdr
THTHE16_RS03635	COG2030	dehydratase
THTHE16_RS03645	COG0596	Alpha beta hydrolase
THTHE16_RS03650	COG0318	PFAM AMP-dependent synthetase and ligase
THTHE16_RS03665	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THTHE16_RS03665	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THTHE16_RS03675	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
THTHE16_RS03685	COG0195	Participates in both transcription termination and antitermination
THTHE16_RS03690	COG0779	Required for maturation of 30S ribosomal subunits
THTHE16_RS03700	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
THTHE16_RS03705	COG0640	Transcriptional regulator
THTHE16_RS03710	COG2217	Heavy metal translocating P-type atpase
THTHE16_RS03715	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
THTHE16_RS03720	COG0017	Asparaginyl-tRNA synthetase
THTHE16_RS03725	COG0561	phosphatase activity
THTHE16_RS03730	COG0384	phenazine biosynthesis protein PhzF
THTHE16_RS03740	COG0124	histidyl-tRNA synthetase
THTHE16_RS03750	COG3842	ATPase activity
THTHE16_RS03765	COG1573	uracil-dna glycosylase
THTHE16_RS03785	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
THTHE16_RS03800	COG1316	TRANSCRIPTIONal
THTHE16_RS03810	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
THTHE16_RS03855	COG0295	cytidine deaminase activity
THTHE16_RS03865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THTHE16_RS03875	COG1760	l-serine dehydratase
THTHE16_RS03885	COG0481	GTPase activity
THTHE16_RS03895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THTHE16_RS03910	COG1028	Short-chain dehydrogenase reductase Sdr
THTHE16_RS03935	COG0405	Gamma-glutamyltransferase
THTHE16_RS03940	COG1073	alpha beta
THTHE16_RS03955	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
THTHE16_RS03960	COG2873	o-acetylhomoserine
THTHE16_RS03975	COG1063	alcohol dehydrogenase
THTHE16_RS03985	COG3191	aminopeptidase activity
THTHE16_RS03990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THTHE16_RS03995	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THTHE16_RS04000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THTHE16_RS04005	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THTHE16_RS04005	COG1116	anion transmembrane transporter activity
THTHE16_RS04010	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THTHE16_RS04020	COG0167	dihydroorotate dehydrogenase activity
THTHE16_RS04055	COG0730	response to heat
THTHE16_RS04060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THTHE16_RS04075	COG0312	modulator of DNA gyrase
THTHE16_RS04080	COG0312	modulator of DNA gyrase
THTHE16_RS04090	COG1960	acyl-CoA dehydrogenase activity
THTHE16_RS04095	COG0456	acetyltransferase
THTHE16_RS04105	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
THTHE16_RS04110	COG0009	L-threonylcarbamoyladenylate synthase
THTHE16_RS04115	COG1459	type II secretion system
THTHE16_RS04130	COG0277	FAD linked oxidase domain protein
THTHE16_RS04140	COG0287	Prephenate dehydrogenase
THTHE16_RS04145	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
THTHE16_RS04150	COG2514	catechol 2,3-dioxygenase activity
THTHE16_RS04155	COG2353	YceI-like domain
THTHE16_RS04160	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
THTHE16_RS04165	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
THTHE16_RS04185	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THTHE16_RS04190	COG0179	Fumarylacetoacetate (FAA) hydrolase
THTHE16_RS04200	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
THTHE16_RS04205	COG0151	Belongs to the GarS family
THTHE16_RS04210	COG5002	protein histidine kinase activity
THTHE16_RS04210	COG2176	DNA-directed DNA polymerase activity
THTHE16_RS04240	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
THTHE16_RS04250	COG0217	transcriptional regulatory protein
THTHE16_RS04255	COG4651	solute:proton antiporter activity
THTHE16_RS04255	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
THTHE16_RS04260	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
THTHE16_RS04265	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THTHE16_RS04270	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
THTHE16_RS04275	COG1674	ftsk spoiiie
THTHE16_RS04290	COG0517	IMP dehydrogenase activity
THTHE16_RS04305	COG3620	sequence-specific DNA binding
THTHE16_RS04305	COG0617	tRNA 3'-terminal CCA addition
THTHE16_RS04305	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THTHE16_RS04315	COG1994	Peptidase M50
THTHE16_RS04320	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
THTHE16_RS04330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THTHE16_RS04345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THTHE16_RS04350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THTHE16_RS04355	COG2719	SpoVR family
THTHE16_RS04360	COG2718	Belongs to the UPF0229 family
THTHE16_RS04365	COG2766	serine protein kinase
THTHE16_RS04390	COG2137	regulation of response to DNA damage stimulus
THTHE16_RS04400	COG2359	stage V sporulation protein S
THTHE16_RS04405	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
THTHE16_RS04410	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
THTHE16_RS04420	COG0463	Glycosyl transferase, family 2
THTHE16_RS04425	COG0750	zinc metalloprotease
THTHE16_RS04430	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
THTHE16_RS04435	COG4589	Belongs to the CDS family
THTHE16_RS04440	COG0233	cytoplasmic translational termination
THTHE16_RS04445	COG0528	UMP kinase activity
THTHE16_RS04450	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
THTHE16_RS04455	COG0052	Belongs to the universal ribosomal protein uS2 family
THTHE16_RS04465	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
THTHE16_RS04470	COG0494	nUDIX hydrolase
THTHE16_RS04495	COG0402	S-adenosylhomocysteine deaminase activity
THTHE16_RS04505	COG4948	Mandelate Racemase Muconate Lactonizing
THTHE16_RS04510	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
THTHE16_RS04515	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THTHE16_RS04520	COG1811	Na channel or pump
THTHE16_RS04525	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
THTHE16_RS04525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THTHE16_RS04540	COG1215	transferase activity, transferring glycosyl groups
THTHE16_RS04550	COG1215	transferase activity, transferring glycosyl groups
THTHE16_RS04560	COG0438	transferase activity, transferring glycosyl groups
THTHE16_RS04565	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
THTHE16_RS04580	COG1250	3-hydroxyacyl-CoA dehydrogenase
THTHE16_RS04580	COG1024	Enoyl-CoA hydratase
THTHE16_RS04585	COG0183	Belongs to the thiolase family
THTHE16_RS04590	COG1960	acyl-CoA dehydrogenase activity
THTHE16_RS04595	COG0215	cysteine-tRNA ligase activity
THTHE16_RS04600	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
THTHE16_RS04615	COG2873	o-acetylhomoserine
THTHE16_RS04635	COG1196	nuclear chromosome segregation
THTHE16_RS04650	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
THTHE16_RS04660	COG1268	BioY protein
THTHE16_RS04670	COG0126	phosphoglycerate kinase activity
THTHE16_RS04675	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
THTHE16_RS04680	COG0824	Thioesterase
THTHE16_RS04690	COG0557	exoribonuclease II activity
THTHE16_RS04695	COG1355	regulation of microtubule-based process
THTHE16_RS04700	COG1353	crispr-associated protein
THTHE16_RS04700	COG0617	tRNA 3'-terminal CCA addition
THTHE16_RS04705	COG0237	dephospho-CoA kinase activity
THTHE16_RS04720	COG0742	ribosomal rna small subunit methyltransferase
THTHE16_RS04725	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
THTHE16_RS04730	COG0138	bifunctional purine biosynthesis protein purh
THTHE16_RS04735	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THTHE16_RS04745	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
THTHE16_RS04780	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
THTHE16_RS04820	COG0149	triose-phosphate isomerase activity
THTHE16_RS04825	COG3239	Fatty acid desaturase
THTHE16_RS04830	COG1490	D-aminoacyl-tRNA deacylase activity
THTHE16_RS04835	COG1307	EDD domain protein, DegV family
THTHE16_RS04840	COG1307	EDD domain protein, DegV family
THTHE16_RS04845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THTHE16_RS04850	COG1510	regulation of RNA biosynthetic process
THTHE16_RS04870	COG1136	(ABC) transporter
THTHE16_RS04885	COG3769	mannosylglycerate metabolic process
THTHE16_RS04895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THTHE16_RS04905	COG1012	belongs to the aldehyde dehydrogenase family
THTHE16_RS04910	COG2368	4-hydroxyphenylacetate
THTHE16_RS04915	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
THTHE16_RS04945	COG2050	protein possibly involved in aromatic compounds catabolism
THTHE16_RS04950	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
THTHE16_RS04975	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
THTHE16_RS04990	COG0438	transferase activity, transferring glycosyl groups
THTHE16_RS04995	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
THTHE16_RS05025	COG1085	galactose-1-phosphate uridylyltransferase
THTHE16_RS05040	COG1012	belongs to the aldehyde dehydrogenase family
THTHE16_RS05040	COG2030	dehydratase
THTHE16_RS05060	COG3396	Phenylacetate-CoA oxygenase
THTHE16_RS05065	COG1309	transcriptional regulator
THTHE16_RS05070	COG4974	Belongs to the 'phage' integrase family
THTHE16_RS05075	COG3842	ATPase activity
THTHE16_RS05080	COG0395	ABC-type sugar transport system, permease component
THTHE16_RS05100	COG1980	fructose-bisphosphate aldolase activity
THTHE16_RS05105	COG1733	regulation of RNA biosynthetic process
THTHE16_RS05110	COG2193	ferroxidase activity
THTHE16_RS05115	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
THTHE16_RS05120	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
THTHE16_RS05130	COG1331	Highly conserved protein containing a thioredoxin domain
THTHE16_RS05135	COG0183	Belongs to the thiolase family
THTHE16_RS05140	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
THTHE16_RS05145	COG0477	Major facilitator Superfamily
THTHE16_RS05150	COG1846	Transcriptional regulator
THTHE16_RS05165	COG2199	diguanylate cyclase activity
THTHE16_RS05165	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THTHE16_RS05170	COG1012	belongs to the aldehyde dehydrogenase family
THTHE16_RS05175	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
THTHE16_RS05180	COG0210	DNA helicase
THTHE16_RS05195	COG0745	RESPONSE REGULATOR receiver
THTHE16_RS05200	COG2205	protein histidine kinase activity
THTHE16_RS05215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THTHE16_RS05220	COG1136	(ABC) transporter
THTHE16_RS05225	COG1136	(ABC) transporter
THTHE16_RS05225	COG0577	efflux transmembrane transporter activity
THTHE16_RS05230	COG1309	transcriptional regulator
THTHE16_RS05295	COG0582	viral genome integration into host DNA
THTHE16_RS05305	COG2897	thiosulfate sulfurtransferase activity
THTHE16_RS05310	COG1760	l-serine dehydratase
THTHE16_RS05315	COG2197	response regulator
THTHE16_RS05320	COG0335	large ribosomal subunit rRNA binding
THTHE16_RS05325	COG0336	Belongs to the RNA methyltransferase TrmD family
THTHE16_RS05330	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
THTHE16_RS05335	COG1837	Belongs to the UPF0109 family
THTHE16_RS05340	COG0228	four-way junction DNA binding
THTHE16_RS05355	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
THTHE16_RS05360	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
THTHE16_RS05360	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
THTHE16_RS05365	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
THTHE16_RS05375	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
THTHE16_RS05385	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
THTHE16_RS05390	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
THTHE16_RS05395	COG1702	phosphate starvation-inducible protein PhoH
THTHE16_RS05405	COG4864	UPF0365 protein
THTHE16_RS05415	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THTHE16_RS05435	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THTHE16_RS05435	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THTHE16_RS05440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THTHE16_RS05450	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
THTHE16_RS05460	COG2239	Acts as a magnesium transporter
THTHE16_RS05465	COG2304	oxidoreductase activity
THTHE16_RS05470	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
THTHE16_RS05470	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
THTHE16_RS05480	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THTHE16_RS05480	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THTHE16_RS05485	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
THTHE16_RS05490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
THTHE16_RS05495	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
THTHE16_RS05500	COG0006	proline dipeptidase activity
THTHE16_RS05510	COG0739	heme binding
THTHE16_RS05520	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
THTHE16_RS05525	COG0254	rRNA binding
THTHE16_RS05535	COG2001	Belongs to the MraZ family
THTHE16_RS05540	COG0275	rRNA processing
THTHE16_RS05550	COG0768	penicillin binding
THTHE16_RS05555	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
THTHE16_RS05565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THTHE16_RS05570	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
THTHE16_RS05575	COG0772	Belongs to the SEDS family
THTHE16_RS05580	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THTHE16_RS05585	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THTHE16_RS05590	COG0812	UDP-N-acetylmuramate dehydrogenase activity
THTHE16_RS05610	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
THTHE16_RS05620	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
THTHE16_RS05630	COG0159	tryptophan synthase activity
THTHE16_RS05635	COG0133	tryptophan synthase activity
THTHE16_RS05640	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
THTHE16_RS05645	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THTHE16_RS05650	COG1744	ABC transporter substrate-binding protein PnrA-like
THTHE16_RS05655	COG3845	ABC transporter
THTHE16_RS05705	COG0438	transferase activity, transferring glycosyl groups
THTHE16_RS05710	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THTHE16_RS05720	COG0039	L-malate dehydrogenase activity
THTHE16_RS05725	COG2819	hydrolase of the alpha beta superfamily
THTHE16_RS05740	COG0247	lactate metabolic process
THTHE16_RS05740	COG2181	nitrate reductase activity
THTHE16_RS05750	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
THTHE16_RS05755	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
THTHE16_RS05760	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THTHE16_RS05770	COG0439	Biotin carboxylase
THTHE16_RS05775	COG0511	ligase activity, forming carbon-carbon bonds
THTHE16_RS05780	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
THTHE16_RS05800	COG0010	Belongs to the arginase family
THTHE16_RS05815	COG1100	Small GTP-binding protein
THTHE16_RS05825	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
THTHE16_RS05830	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
THTHE16_RS05840	COG2814	Major facilitator Superfamily
THTHE16_RS05855	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
THTHE16_RS05860	COG1185	polyribonucleotide nucleotidyltransferase activity
THTHE16_RS05865	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
THTHE16_RS05870	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
THTHE16_RS05875	COG0745	RESPONSE REGULATOR receiver
THTHE16_RS05880	COG5002	protein histidine kinase activity
THTHE16_RS05885	COG1960	acyl-CoA dehydrogenase activity
THTHE16_RS05890	COG2086	electron transfer activity
THTHE16_RS05895	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
THTHE16_RS05905	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
THTHE16_RS05910	COG1573	uracil-dna glycosylase
THTHE16_RS05915	COG1796	DNA polymerase
THTHE16_RS05915	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
THTHE16_RS05930	COG2309	aminopeptidase activity
THTHE16_RS05950	COG2873	o-acetylhomoserine
THTHE16_RS05970	COG2358	TRAP transporter, solute receptor (TAXI family
THTHE16_RS05990	COG1752	Esterase of the alpha-beta hydrolase superfamily
THTHE16_RS05995	COG3311	Transcriptional regulator
THTHE16_RS06005	COG0134	indole-3-glycerol-phosphate synthase activity
THTHE16_RS06010	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
THTHE16_RS06020	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
THTHE16_RS06035	COG0765	amino acid transport
THTHE16_RS06040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THTHE16_RS06050	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
THTHE16_RS06055	COG0569	domain protein
THTHE16_RS06060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THTHE16_RS06065	COG1426	Protein conserved in bacteria
THTHE16_RS06080	COG3001	Fructosamine kinase
THTHE16_RS06085	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THTHE16_RS06095	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
THTHE16_RS06120	COG0012	GTP binding
THTHE16_RS06125	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
THTHE16_RS06130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
THTHE16_RS06135	COG0424	maF-like protein
THTHE16_RS06150	COG0768	penicillin binding
THTHE16_RS06155	COG0850	regulation of cytokinetic process
THTHE16_RS06180	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
THTHE16_RS06185	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
THTHE16_RS06195	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
THTHE16_RS06205	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THTHE16_RS06215	COG1131	(ABC) transporter
THTHE16_RS06230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THTHE16_RS06245	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
THTHE16_RS06250	COG0440	acetolactate synthase activity
THTHE16_RS06255	COG0028	Belongs to the TPP enzyme family
THTHE16_RS06260	COG0492	ferredoxin-NADP+ reductase activity
THTHE16_RS06265	COG4970	Tfp pilus assembly protein FimT
THTHE16_RS06270	COG4970	Tfp pilus assembly protein FimT
THTHE16_RS06275	COG2165	general secretion pathway protein
THTHE16_RS06280	COG4966	pilus assembly protein PilW
THTHE16_RS06305	COG4636	protein conserved in cyanobacteria
THTHE16_RS06325	COG0180	Tryptophanyl-tRNA synthetase
THTHE16_RS06330	COG0544	peptidyl-prolyl cis-trans isomerase activity
THTHE16_RS06340	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THTHE16_RS06345	COG0066	3-isopropylmalate dehydratase activity
THTHE16_RS06350	COG0473	3-isopropylmalate dehydrogenase activity
THTHE16_RS06365	COG0300	oxidoreductase activity
THTHE16_RS06370	COG0129	dihydroxy-acid dehydratase activity
THTHE16_RS06380	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
THTHE16_RS06385	COG1177	transmembrane transport
THTHE16_RS06390	COG1176	ABC-type spermidine putrescine transport system, permease component I
THTHE16_RS06395	COG3842	ATPase activity
THTHE16_RS06400	COG0772	Belongs to the SEDS family
THTHE16_RS06405	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
THTHE16_RS06410	COG2894	cell division
THTHE16_RS06415	COG1733	regulation of RNA biosynthetic process
THTHE16_RS06425	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
THTHE16_RS06425	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
THTHE16_RS06435	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THTHE16_RS06440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THTHE16_RS06445	COG0653	protein targeting
THTHE16_RS06450	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
THTHE16_RS06470	COG0393	Putative heavy-metal-binding
THTHE16_RS06475	COG1111	helicase
THTHE16_RS06475	COG1205	dead DEAH box helicase
THTHE16_RS06490	COG0358	DNA primase activity
THTHE16_RS06500	COG1250	3-hydroxyacyl-CoA dehydrogenase
THTHE16_RS06505	COG0697	spore germination
THTHE16_RS06510	COG0612	Peptidase, M16
THTHE16_RS06515	COG0612	Peptidase, M16
THTHE16_RS06520	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THTHE16_RS06535	COG1394	ATPase activity, coupled to movement of substances
THTHE16_RS06540	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
THTHE16_RS06545	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
THTHE16_RS06550	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
THTHE16_RS06555	COG1527	subunit (C
THTHE16_RS06560	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
THTHE16_RS06570	COG1269	ATP hydrolysis coupled proton transport
THTHE16_RS06595	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
THTHE16_RS06605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THTHE16_RS06620	COG0419	ATPase involved in DNA repair
THTHE16_RS06625	COG0420	3'-5' exonuclease activity
THTHE16_RS06645	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
THTHE16_RS06650	COG2884	Cell division ATP-binding protein ftsE
THTHE16_RS06655	COG0793	Belongs to the peptidase S41A family
THTHE16_RS06665	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THTHE16_RS06665	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THTHE16_RS06670	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
THTHE16_RS06675	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THTHE16_RS06685	COG1079	Belongs to the binding-protein-dependent transport system permease family
THTHE16_RS06690	COG4603	Belongs to the binding-protein-dependent transport system permease family
THTHE16_RS06695	COG1129	ABC transporter
THTHE16_RS06700	COG0746	molybdenum cofactor guanylyltransferase activity
THTHE16_RS06715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THTHE16_RS06735	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
THTHE16_RS06740	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THTHE16_RS06745	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
THTHE16_RS06760	COG2358	TRAP transporter, solute receptor (TAXI family
THTHE16_RS06770	COG2358	TRAP transporter, solute receptor (TAXI family
THTHE16_RS06790	COG0788	formyltetrahydrofolate deformylase activity
THTHE16_RS06795	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
THTHE16_RS06800	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
THTHE16_RS06805	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THTHE16_RS06825	COG0737	Belongs to the 5'-nucleotidase family
THTHE16_RS06830	COG0174	glutamine synthetase
THTHE16_RS06840	COG0559	Belongs to the binding-protein-dependent transport system permease family
THTHE16_RS06860	COG0747	negative chemotaxis
THTHE16_RS06865	COG0601	transmembrane transport
THTHE16_RS06870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THTHE16_RS06880	COG0285	dihydrofolate synthase activity
THTHE16_RS06885	COG1132	(ABC) transporter
THTHE16_RS06890	COG1132	(ABC) transporter
THTHE16_RS06895	COG0372	Belongs to the citrate synthase family
THTHE16_RS06900	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
THTHE16_RS06905	COG1482	cell wall glycoprotein biosynthetic process
THTHE16_RS06915	COG1515	deoxyribonuclease V activity
THTHE16_RS06925	COG0776	regulation of translation
THTHE16_RS06940	COG2197	response regulator
THTHE16_RS06945	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THTHE16_RS06950	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
THTHE16_RS06955	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
THTHE16_RS06960	COG1324	tolerance protein
THTHE16_RS06975	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THTHE16_RS06995	COG2205	protein histidine kinase activity
THTHE16_RS07000	COG0247	lactate metabolic process
THTHE16_RS07005	COG1139	Iron-sulfur cluster binding protein
THTHE16_RS07010	COG1556	Lactate utilization protein
THTHE16_RS07020	COG1752	Esterase of the alpha-beta hydrolase superfamily
THTHE16_RS07025	COG0515	serine threonine protein kinase
THTHE16_RS07025	COG2815	serine threonine protein kinase
THTHE16_RS07030	COG0860	N-Acetylmuramoyl-L-alanine amidase
THTHE16_RS07040	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
THTHE16_RS07070	COG0473	3-isopropylmalate dehydrogenase activity
THTHE16_RS07095	COG1450	Type ii and iii secretion system protein
THTHE16_RS07100	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
THTHE16_RS07105	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
THTHE16_RS07110	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
THTHE16_RS07115	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
THTHE16_RS07115	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
THTHE16_RS07120	COG0736	holo-[acyl-carrier-protein] synthase activity
THTHE16_RS07135	COG1160	GTP binding
THTHE16_RS07140	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
THTHE16_RS07145	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THTHE16_RS07145	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
THTHE16_RS07150	COG0083	homoserine kinase activity
THTHE16_RS07165	COG0268	Binds directly to 16S ribosomal RNA
THTHE16_RS07175	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
THTHE16_RS07180	COG0723	plastoquinol--plastocyanin reductase activity
THTHE16_RS07190	COG3088	subunit of a heme lyase
THTHE16_RS07190	COG4235	cytochrome complex assembly
THTHE16_RS07195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THTHE16_RS07200	COG1138	Cytochrome C-type biogenesis protein
THTHE16_RS07205	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
THTHE16_RS07210	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
THTHE16_RS07215	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
THTHE16_RS07220	COG4133	protoheme IX ABC transporter activity
THTHE16_RS07225	COG0785	Cytochrome C biogenesis protein
THTHE16_RS07230	COG3258	Cytochrome c
THTHE16_RS07240	COG0446	pyridine nucleotide-disulphide oxidoreductase
THTHE16_RS07255	COG3258	Cytochrome c
THTHE16_RS07260	COG2010	Cytochrome c
THTHE16_RS07265	COG0737	Belongs to the 5'-nucleotidase family
THTHE16_RS07270	COG2010	Cytochrome c
THTHE16_RS07275	COG3258	Cytochrome c
THTHE16_RS07295	COG2010	Cytochrome c
THTHE16_RS07300	COG3842	ATPase activity
THTHE16_RS07330	COG0318	PFAM AMP-dependent synthetase and ligase
THTHE16_RS07335	COG3360	Dodecin
THTHE16_RS07350	COG1024	Enoyl-CoA hydratase
THTHE16_RS07355	COG0813	purine-nucleoside phosphorylase activity
THTHE16_RS07360	COG1136	(ABC) transporter
THTHE16_RS07365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THTHE16_RS07370	COG2045	Belongs to the ComB family
THTHE16_RS07380	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
THTHE16_RS07390	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
THTHE16_RS07400	COG0107	imidazoleglycerol-phosphate synthase activity
THTHE16_RS07405	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
THTHE16_RS07405	COG0140	phosphoribosyl-ATP diphosphatase activity
THTHE16_RS07410	COG1494	fructose-1,6-bisphosphatase
THTHE16_RS07415	COG0686	Belongs to the AlaDH PNT family
THTHE16_RS07420	COG0427	acetyl-CoA hydrolase
THTHE16_RS07425	COG0084	hydrolase, TatD family'
THTHE16_RS07430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
THTHE16_RS07440	COG0017	Asparaginyl-tRNA synthetase
THTHE16_RS07450	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
THTHE16_RS07465	COG2009	succinate dehydrogenase
THTHE16_RS07470	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
THTHE16_RS07500	COG0318	PFAM AMP-dependent synthetase and ligase
THTHE16_RS07505	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
THTHE16_RS07510	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
THTHE16_RS07515	COG0504	CTP synthase activity
THTHE16_RS07530	COG0070	glutamate synthase
THTHE16_RS07530	COG0069	glutamate synthase activity
THTHE16_RS07530	COG0067	glutamate synthase
THTHE16_RS07535	COG0840	transmembrane signaling receptor activity
THTHE16_RS07540	COG0305	Participates in initiation and elongation during chromosome replication
THTHE16_RS07550	COG0475	glutathione-regulated potassium exporter activity
THTHE16_RS07555	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THTHE16_RS07555	COG0617	tRNA 3'-terminal CCA addition
THTHE16_RS07555	COG0517	IMP dehydrogenase activity
THTHE16_RS07575	COG0490	domain, Protein
THTHE16_RS07595	COG3118	belongs to the thioredoxin family
THTHE16_RS07610	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THTHE16_RS07650	COG0542	response to heat
THTHE16_RS07655	COG0789	Transcriptional regulator
THTHE16_RS07660	COG0484	heat shock protein binding
THTHE16_RS07665	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THTHE16_RS07670	COG0443	Heat shock 70 kDa protein
THTHE16_RS07675	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THTHE16_RS07680	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
THTHE16_RS07685	COG0616	signal peptide processing
THTHE16_RS07690	COG1714	RDD family
THTHE16_RS07700	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
THTHE16_RS07705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THTHE16_RS07710	COG0714	Associated with various cellular activities
THTHE16_RS07715	COG0574	Belongs to the PEP-utilizing enzyme family
THTHE16_RS07715	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THTHE16_RS07720	COG1272	protein, Hemolysin III
THTHE16_RS07730	COG5002	protein histidine kinase activity
THTHE16_RS07730	COG3850	Histidine kinase
THTHE16_RS07750	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
THTHE16_RS07765	COG1011	Hydrolase
THTHE16_RS07785	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
THTHE16_RS07800	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
THTHE16_RS07810	COG0047	phosphoribosylformylglycinamidine synthase activity
THTHE16_RS07820	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THTHE16_RS07825	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
THTHE16_RS07830	COG0116	Belongs to the methyltransferase superfamily
THTHE16_RS07845	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
THTHE16_RS07850	COG0497	DNA recombination
THTHE16_RS07860	COG0604	alcohol dehydrogenase
THTHE16_RS07880	COG0585	pseudouridine synthase activity
THTHE16_RS07895	COG0557	exoribonuclease II activity
THTHE16_RS07900	COG0538	isocitrate dehydrogenase activity
THTHE16_RS07950	COG2050	protein possibly involved in aromatic compounds catabolism
THTHE16_RS07960	COG0322	excinuclease ABC activity
THTHE16_RS07965	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
THTHE16_RS07970	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
THTHE16_RS07975	COG1854	S-ribosylhomocysteine lyase activity
THTHE16_RS07990	COG0519	Catalyzes the synthesis of GMP from XMP
THTHE16_RS07990	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THTHE16_RS07995	COG4636	protein conserved in cyanobacteria
THTHE16_RS08000	COG4274	PFAM GYD family protein
THTHE16_RS08005	COG0346	lactoylglutathione lyase activity
THTHE16_RS08010	COG0328	RNA-DNA hybrid ribonuclease activity
THTHE16_RS08015	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
THTHE16_RS08020	COG2095	MarC family integral membrane protein
THTHE16_RS08025	COG1438	arginine binding
THTHE16_RS08030	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THTHE16_RS08035	COG1758	RNA polymerase activity
THTHE16_RS08040	COG0194	GDP metabolic process
THTHE16_RS08050	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
THTHE16_RS08055	COG2385	sporulation resulting in formation of a cellular spore
THTHE16_RS08060	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
THTHE16_RS08070	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
THTHE16_RS08110	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
THTHE16_RS08115	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
THTHE16_RS08120	COG1012	belongs to the aldehyde dehydrogenase family
THTHE16_RS08125	COG0506	proline dehydrogenase activity
THTHE16_RS08150	COG0156	8-amino-7-oxononanoate synthase activity
THTHE16_RS08155	COG0827	DNA restriction-modification system
THTHE16_RS08155	COG0732	type I restriction modification DNA specificity domain
THTHE16_RS08165	COG0187	DNA topoisomerase II activity
THTHE16_RS08170	COG1181	Belongs to the D-alanine--D-alanine ligase family
THTHE16_RS08175	COG0193	aminoacyl-tRNA hydrolase activity
THTHE16_RS08180	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
THTHE16_RS08205	COG0515	serine threonine protein kinase
THTHE16_RS08205	COG2815	serine threonine protein kinase
THTHE16_RS08210	COG0631	protein serine/threonine phosphatase activity
THTHE16_RS08225	COG0113	porphobilinogen synthase activity
THTHE16_RS08230	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
THTHE16_RS08235	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
THTHE16_RS08260	COG0823	Involved in the tonB-independent uptake of proteins
THTHE16_RS08260	COG1506	peptidase
THTHE16_RS08260	COG4946	Tricorn protease homolog
THTHE16_RS08265	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
THTHE16_RS08270	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
THTHE16_RS08290	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
THTHE16_RS08295	COG1011	Hydrolase
THTHE16_RS08320	COG0537	adenosine 5'-monophosphoramidase activity
THTHE16_RS08325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THTHE16_RS08330	COG0220	tRNA (guanine-N7-)-methyltransferase activity
THTHE16_RS08335	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
THTHE16_RS08340	COG0071	Belongs to the small heat shock protein (HSP20) family
THTHE16_RS08345	COG2897	thiosulfate sulfurtransferase activity
THTHE16_RS08350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THTHE16_RS08360	COG1764	response to oxidative stress
THTHE16_RS08375	COG1840	ABC-type Fe3 transport system, periplasmic component
THTHE16_RS08385	COG3842	ATPase activity
THTHE16_RS08390	COG0101	tRNA pseudouridine synthase activity
THTHE16_RS08395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THTHE16_RS08400	COG0601	transmembrane transport
THTHE16_RS08410	COG0316	Belongs to the HesB IscA family
THTHE16_RS08415	COG0006	proline dipeptidase activity
THTHE16_RS08420	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
THTHE16_RS08435	COG1166	arginine decarboxylase activity
THTHE16_RS08440	COG3706	GGDEF domain
THTHE16_RS08445	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THTHE16_RS08450	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
THTHE16_RS08455	COG1611	Belongs to the LOG family
THTHE16_RS08460	COG1193	negative regulation of DNA recombination
THTHE16_RS08465	COG0366	Alpha amylase catalytic
THTHE16_RS08490	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
THTHE16_RS08495	COG0142	geranyltranstransferase activity
THTHE16_RS08510	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
THTHE16_RS08540	COG0203	ribosomal protein L17
THTHE16_RS08545	COG0202	RNA polymerase activity
THTHE16_RS08550	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
THTHE16_RS08555	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
THTHE16_RS08560	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
THTHE16_RS08570	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
THTHE16_RS08580	COG0563	adenylate kinase activity
THTHE16_RS08585	COG0201	protein transport
THTHE16_RS08610	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
THTHE16_RS08615	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
THTHE16_RS08620	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
THTHE16_RS08645	COG0255	Belongs to the universal ribosomal protein uL29 family
THTHE16_RS08650	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
THTHE16_RS08655	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
THTHE16_RS08665	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
THTHE16_RS08670	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
THTHE16_RS08675	COG0089	rRNA binding
THTHE16_RS08680	COG0088	Forms part of the polypeptide exit tunnel
THTHE16_RS08690	COG0051	transcription antitermination factor activity, RNA binding
THTHE16_RS08695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THTHE16_RS08700	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THTHE16_RS08705	COG0049	tRNA binding
THTHE16_RS08720	COG0442	prolyl-tRNA aminoacylation
THTHE16_RS08730	COG1115	amino acid carrier protein
THTHE16_RS08750	COG1489	DNA binding
THTHE16_RS08775	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
THTHE16_RS08795	COG0432	Pfam Uncharacterised protein family UPF0047
THTHE16_RS08800	COG3253	May function as heme-dependent peroxidase
THTHE16_RS08805	COG0668	transmembrane transport
THTHE16_RS08815	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THTHE16_RS08820	COG2217	Heavy metal translocating P-type atpase
THTHE16_RS08840	COG0745	RESPONSE REGULATOR receiver
THTHE16_RS08845	COG2205	protein histidine kinase activity
THTHE16_RS08885	COG2132	Multicopper oxidase
THTHE16_RS08895	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THTHE16_RS08900	COG0822	iron-sulfur transferase activity
THTHE16_RS08920	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
THTHE16_RS08930	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
THTHE16_RS08935	COG0284	orotidine-5'-phosphate decarboxylase activity
THTHE16_RS08945	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
THTHE16_RS08950	COG1371	PFAM Archease protein family (DUF101 UPF0211)
THTHE16_RS08955	COG0416	fatty acid biosynthetic process
THTHE16_RS08960	COG3118	belongs to the thioredoxin family
THTHE16_RS08965	COG1185	polyribonucleotide nucleotidyltransferase activity
THTHE16_RS08970	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
THTHE16_RS08980	COG0438	transferase activity, transferring glycosyl groups
THTHE16_RS08995	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THTHE16_RS09010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
THTHE16_RS09015	COG3706	GGDEF domain
THTHE16_RS09025	COG1252	NADH dehydrogenase
THTHE16_RS09050	COG0437	4 iron, 4 sulfur cluster binding
THTHE16_RS09065	COG0825	malonyl-CoA metabolic process
THTHE16_RS09070	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
THTHE16_RS09105	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
THTHE16_RS09130	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
THTHE16_RS09135	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THTHE16_RS09140	COG0211	Belongs to the bacterial ribosomal protein bL27 family
THTHE16_RS09145	COG0261	This protein binds to 23S rRNA in the presence of protein L20
THTHE16_RS09185	COG0315	cyclic pyranopterin monophosphate synthase activity
THTHE16_RS09190	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
THTHE16_RS09205	COG0477	Major facilitator Superfamily
THTHE16_RS09210	COG1694	Mazg nucleotide pyrophosphohydrolase
THTHE16_RS09215	COG1803	Methylglyoxal synthase
THTHE16_RS09225	COG0301	tRNA thio-modification
THTHE16_RS09230	COG0154	amidase activity
THTHE16_RS09250	COG2154	pterin-4-alpha-carbinolamine dehydratase
THTHE16_RS09255	COG1607	acyl-coa hydrolase
THTHE16_RS09265	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
THTHE16_RS09270	COG4149	molybdate abc transporter
THTHE16_RS09275	COG1840	ABC-type Fe3 transport system, periplasmic component
THTHE16_RS09290	COG0235	Class ii aldolase
THTHE16_RS09295	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
THTHE16_RS09300	COG0085	RNA polymerase activity
THTHE16_RS09310	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THTHE16_RS09315	COG1077	Cell shape determining protein MreB Mrl
THTHE16_RS09320	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
THTHE16_RS09320	COG1418	mRNA catabolic process
THTHE16_RS09325	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
THTHE16_RS09330	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
THTHE16_RS09335	COG1546	Belongs to the CinA family
THTHE16_RS09335	COG1058	Belongs to the CinA family
THTHE16_RS09340	COG0354	folic acid binding
THTHE16_RS09370	COG1175	transmembrane transport
THTHE16_RS09380	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
THTHE16_RS09390	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
THTHE16_RS09400	COG1136	(ABC) transporter
THTHE16_RS09400	COG0577	efflux transmembrane transporter activity
THTHE16_RS09405	COG4181	ATPase activity
THTHE16_RS09410	COG0446	pyridine nucleotide-disulphide oxidoreductase
THTHE16_RS09425	COG0396	ATPase activity
THTHE16_RS09430	COG0719	Fe-S assembly protein
THTHE16_RS09435	COG0719	Fe-S assembly protein
THTHE16_RS09440	COG2146	nitrite reductase [NAD(P)H] activity
THTHE16_RS09450	COG0512	Glutamine amidotransferase of anthranilate synthase
THTHE16_RS09455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
THTHE16_RS09480	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THTHE16_RS09485	COG2226	methyltransferase
THTHE16_RS09490	COG4603	Belongs to the binding-protein-dependent transport system permease family
THTHE16_RS09495	COG1079	Belongs to the binding-protein-dependent transport system permease family
THTHE16_RS09510	COG1774	PSP1 C-terminal conserved region
THTHE16_RS09515	COG0470	DNA polymerase III
THTHE16_RS09545	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THTHE16_RS09560	COG0302	gtp cyclohydrolase
THTHE16_RS09590	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
THTHE16_RS09600	COG0395	ABC-type sugar transport system, permease component
THTHE16_RS09605	COG1804	L-carnitine dehydratase bile acid-inducible protein F
THTHE16_RS09610	COG1131	(ABC) transporter
THTHE16_RS09630	COG0556	nucleotide-excision repair
THTHE16_RS09635	COG0497	DNA recombination
THTHE16_RS09640	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THTHE16_RS09650	COG0445	tRNA wobble uridine modification
THTHE16_RS09675	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THTHE16_RS09675	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THTHE16_RS09680	COG1543	Belongs to the glycosyl hydrolase 57 family
THTHE16_RS09685	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THTHE16_RS09690	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
THTHE16_RS09695	COG0189	ligase activity
THTHE16_RS09710	COG0066	3-isopropylmalate dehydratase activity
THTHE16_RS09715	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THTHE16_RS09730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THTHE16_RS09735	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
THTHE16_RS09740	COG1960	acyl-CoA dehydrogenase activity
THTHE16_RS09745	COG0163	prenyltransferase activity
THTHE16_RS09790	COG4555	ABC transporter
THTHE16_RS09800	COG2096	Adenosyltransferase
THTHE16_RS09815	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
THTHE16_RS09820	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
THTHE16_RS09830	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
THTHE16_RS09835	COG0723	plastoquinol--plastocyanin reductase activity
THTHE16_RS09860	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THTHE16_RS09865	COG1960	acyl-CoA dehydrogenase activity
THTHE16_RS09875	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
THTHE16_RS09895	COG0393	Putative heavy-metal-binding
THTHE16_RS09905	COG3956	TIGRFAM MazG family protein
THTHE16_RS09915	COG0693	protein deglycase activity
THTHE16_RS09920	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THTHE16_RS09930	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THTHE16_RS09935	COG1937	Protein conserved in bacteria
THTHE16_RS09945	COG0674	pyruvate-flavodoxin oxidoreductase activity
THTHE16_RS09945	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THTHE16_RS09950	COG1013	pyruvate-flavodoxin oxidoreductase activity
THTHE16_RS09955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THTHE16_RS09975	COG0205	6-phosphofructokinase activity
THTHE16_RS09980	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
THTHE16_RS09990	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
THTHE16_RS10005	COG2333	competence protein COMEC
THTHE16_RS10005	COG0658	competence protein
THTHE16_RS10010	COG1475	DNA binding
THTHE16_RS10015	COG1192	Involved in chromosome partitioning
THTHE16_RS10020	COG0357	Ribosomal RNA small subunit methyltransferase G
THTHE16_RS10025	COG0445	tRNA wobble uridine modification
THTHE16_RS10390	COG0109	protoheme IX farnesyltransferase activity
THTHE16_RS10390	COG1612	heme a metabolic process
THTHE16_RS10670	COG0081	regulation of translation
THTHE16_RS10710	COG0300	oxidoreductase activity
THTHE16_RS10715	COG0321	lipoyl(octanoyl) transferase activity
THTHE16_RS10850	COG0686	Belongs to the AlaDH PNT family
THTHE16_RS10865	COG1461	Dihydroxyacetone kinase
THTHE16_RS11125	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
THTHE16_RS11325	COG0303	'Molybdopterin
THTHE16_RS11345	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
THTHE16_RS11505	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THTHE16_RS11555	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
THTHE16_RS11560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
THTHE16_RS11795	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
THTHE16_RS12235	COG0604	alcohol dehydrogenase
THTHE16_RS12235	COG1028	Short-chain dehydrogenase reductase Sdr
THTHE16_RS12235	COG3321	synthase
THTHE16_RS12245	COG0747	negative chemotaxis
THTHE16_RS12255	COG0601	transmembrane transport
THTHE16_RS12275	COG2165	general secretion pathway protein
THTHE16_RS12295	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids