locus-tag	class	description
MWM06_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MWM06_RS00015	COG0592	DNA-directed DNA polymerase activity
MWM06_RS00020	COG0148	phosphopyruvate hydratase activity
MWM06_RS00025	COG0469	pyruvate kinase activity
MWM06_RS00035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MWM06_RS00040	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MWM06_RS00050	COG1842	Phage shock protein A
MWM06_RS00070	COG0406	alpha-ribazole phosphatase activity
MWM06_RS00075	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MWM06_RS00080	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MWM06_RS00090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MWM06_RS00095	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
MWM06_RS00100	COG1496	oxidoreductase activity
MWM06_RS00105	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MWM06_RS00110	COG1278	Cold shock
MWM06_RS00130	COG1335	isochorismatase
MWM06_RS00135	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
MWM06_RS00145	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MWM06_RS00155	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MWM06_RS00160	COG1993	acr, cog1993
MWM06_RS00165	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MWM06_RS00170	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MWM06_RS00195	COG0521	Mo-molybdopterin cofactor biosynthetic process
MWM06_RS00200	COG0436	Aminotransferase
MWM06_RS00205	COG0285	dihydrofolate synthase activity
MWM06_RS00215	COG0181	hydroxymethylbilane synthase activity
MWM06_RS00225	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MWM06_RS00230	COG1950	PFAM Membrane protein of
MWM06_RS00235	COG0517	IMP dehydrogenase activity
MWM06_RS00235	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MWM06_RS00245	COG2814	Major facilitator Superfamily
MWM06_RS00260	COG0033	Phosphoglucomutase
MWM06_RS00280	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MWM06_RS00295	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
MWM06_RS00300	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MWM06_RS00320	COG1660	Displays ATPase and GTPase activities
MWM06_RS00325	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MWM06_RS00370	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MWM06_RS00370	COG1845	cytochrome c oxidase, subunit III
MWM06_RS00375	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MWM06_RS00375	COG2010	Cytochrome c
MWM06_RS00380	COG1612	heme a metabolic process
MWM06_RS00380	COG0109	protoheme IX farnesyltransferase activity
MWM06_RS00395	COG0343	queuine tRNA-ribosyltransferase activity
MWM06_RS00400	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MWM06_RS00405	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MWM06_RS00425	COG1940	carbohydrate kinase activity
MWM06_RS00435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MWM06_RS00440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MWM06_RS00450	COG1611	Belongs to the LOG family
MWM06_RS00460	COG1011	Hydrolase
MWM06_RS00465	COG0632	four-way junction helicase activity
MWM06_RS00470	COG1024	Enoyl-CoA hydratase
MWM06_RS00480	COG0508	dehydrogenase complex catalyzes the overall conversion of
MWM06_RS00490	COG1404	Belongs to the peptidase S8 family
MWM06_RS00500	COG0137	argininosuccinate synthase activity
MWM06_RS00505	COG0165	Argininosuccinate lyase
MWM06_RS00525	COG0505	Belongs to the CarA family
MWM06_RS00535	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MWM06_RS00540	COG0166	Belongs to the GPI family
MWM06_RS00550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MWM06_RS00555	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MWM06_RS00560	COG0459	protein refolding
MWM06_RS00565	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
MWM06_RS00570	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MWM06_RS00580	COG0778	Nitroreductase
MWM06_RS00585	COG0791	NLP P60 protein
MWM06_RS00585	COG1388	LysM domain
MWM06_RS00595	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MWM06_RS00605	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MWM06_RS00610	COG0581	inorganic phosphate transmembrane transporter activity
MWM06_RS00615	COG0573	inorganic phosphate transmembrane transporter activity
MWM06_RS00620	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MWM06_RS00625	COG0482	sulfurtransferase activity
MWM06_RS00635	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MWM06_RS00640	COG0735	belongs to the Fur family
MWM06_RS00655	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MWM06_RS00680	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MWM06_RS00685	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MWM06_RS00690	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MWM06_RS00695	COG0250	Participates in transcription elongation, termination and antitermination
MWM06_RS00705	COG0081	regulation of translation
MWM06_RS00725	COG0629	single-stranded DNA binding
MWM06_RS00730	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MWM06_RS00735	COG0359	binds to the 23S rRNA
MWM06_RS00745	COG0300	oxidoreductase activity
MWM06_RS00750	COG0321	lipoyl(octanoyl) transferase activity
MWM06_RS00755	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MWM06_RS00815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MWM06_RS00830	COG1598	PFAM Uncharacterised protein family UPF0150
MWM06_RS00835	COG0022	dehydrogenase e1 component
MWM06_RS00840	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MWM06_RS00845	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MWM06_RS00870	COG2226	methyltransferase
MWM06_RS00875	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MWM06_RS00885	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MWM06_RS00890	COG1187	pseudouridine synthase activity
MWM06_RS00900	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MWM06_RS00905	COG0686	Belongs to the AlaDH PNT family
MWM06_RS00915	COG1461	Dihydroxyacetone kinase
MWM06_RS00925	COG3583	domain protein
MWM06_RS00925	COG3584	3D domain protein
MWM06_RS00930	COG4591	ABC-type transport system involved in lipoprotein release permease component
MWM06_RS00935	COG0222	ribosome binding
MWM06_RS00940	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MWM06_RS00950	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
MWM06_RS00965	COG0697	spore germination
MWM06_RS00975	COG3177	Filamentation induced by cAMP protein fic
MWM06_RS00985	COG0243	molybdopterin cofactor binding
MWM06_RS01005	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MWM06_RS01045	COG0477	Major facilitator Superfamily
MWM06_RS01060	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MWM06_RS01070	COG0105	UTP biosynthetic process
MWM06_RS01075	COG0631	protein serine/threonine phosphatase activity
MWM06_RS01080	COG0583	DNA-binding transcription factor activity
MWM06_RS01090	COG0508	dehydrogenase complex catalyzes the overall conversion of
MWM06_RS01125	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MWM06_RS01135	COG1278	Cold shock
MWM06_RS01140	COG0484	heat shock protein binding
MWM06_RS01145	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MWM06_RS01150	COG1968	undecaprenyl-diphosphatase activity
MWM06_RS01155	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MWM06_RS01160	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MWM06_RS01175	COG1309	transcriptional regulator
MWM06_RS01180	COG4242	Belongs to the peptidase S51 family
MWM06_RS01195	COG0802	atpase or kinase
MWM06_RS01205	COG0539	negative regulation of cytoplasmic translation
MWM06_RS01210	COG0495	leucyl-tRNA aminoacylation
MWM06_RS01230	COG1902	pentaerythritol trinitrate reductase activity
MWM06_RS01255	COG2414	aldehyde ferredoxin oxidoreductase
MWM06_RS01270	COG1187	pseudouridine synthase activity
MWM06_RS01280	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MWM06_RS01285	COG0745	RESPONSE REGULATOR receiver
MWM06_RS01290	COG4191	Histidine kinase
MWM06_RS01295	COG0704	Plays a role in the regulation of phosphate uptake
MWM06_RS01310	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MWM06_RS01320	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MWM06_RS01320	COG0515	serine threonine protein kinase
MWM06_RS01345	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MWM06_RS01350	COG1028	Short-chain dehydrogenase reductase Sdr
MWM06_RS01365	COG0717	Belongs to the dCTP deaminase family
MWM06_RS01370	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
MWM06_RS01375	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MWM06_RS01380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MWM06_RS01405	COG3546	catalase activity
MWM06_RS01410	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MWM06_RS01410	COG0758	DNA mediated transformation
MWM06_RS01415	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MWM06_RS01430	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MWM06_RS01440	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
MWM06_RS01445	COG0442	prolyl-tRNA aminoacylation
MWM06_RS01450	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MWM06_RS01475	COG0513	Belongs to the DEAD box helicase family
MWM06_RS01505	COG4983	Phage plasmid primase, P4 family domain protein
MWM06_RS01540	COG0582	viral genome integration into host DNA
MWM06_RS01560	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MWM06_RS01580	COG2070	2-Nitropropane dioxygenase
MWM06_RS01595	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MWM06_RS01600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MWM06_RS01605	COG0018	arginyl-trna synthetase
MWM06_RS01610	COG1007	ATP synthesis coupled electron transport
MWM06_RS01615	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MWM06_RS01620	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MWM06_RS01625	COG0713	ATP synthesis coupled electron transport
MWM06_RS01630	COG0839	Belongs to the complex I subunit 6 family
MWM06_RS01635	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MWM06_RS01640	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MWM06_RS01645	COG1034	ATP synthesis coupled electron transport
MWM06_RS01650	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
MWM06_RS01655	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
MWM06_RS01660	COG0649	NAD binding
MWM06_RS01665	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MWM06_RS01670	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MWM06_RS01675	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MWM06_RS01680	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MWM06_RS01690	COG4712	double-strand break repair protein
MWM06_RS01705	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MWM06_RS01720	COG0135	phosphoribosylanthranilate isomerase activity
MWM06_RS01725	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MWM06_RS01725	COG1372	Participates in initiation and elongation during chromosome replication
MWM06_RS01730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MWM06_RS01740	COG2720	vancomycin resistance protein
MWM06_RS01745	COG1126	abc transporter atp-binding protein
MWM06_RS01775	COG0277	FAD linked oxidase domain protein
MWM06_RS01790	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MWM06_RS01805	COG0314	molybdopterin synthase activity
MWM06_RS01810	COG1420	regulation of RNA biosynthetic process
MWM06_RS01830	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MWM06_RS01840	COG0123	including yeast histone deacetylase and acetoin utilization protein
MWM06_RS01865	COG1597	lipid kinase activity
MWM06_RS01870	COG0436	Aminotransferase
MWM06_RS01890	COG0569	domain protein
MWM06_RS01890	COG0475	glutathione-regulated potassium exporter activity
MWM06_RS01900	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MWM06_RS01910	COG0277	FAD linked oxidase domain protein
MWM06_RS01940	COG2002	toxin-antitoxin pair type II binding
MWM06_RS01975	COG0667	Aldo Keto reductase
MWM06_RS01995	COG1067	ATP-dependent peptidase activity
MWM06_RS02000	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MWM06_RS02010	COG0745	RESPONSE REGULATOR receiver
MWM06_RS02015	COG2105	PFAM AIG2 family protein
MWM06_RS02020	COG0297	glycogen (starch) synthase activity
MWM06_RS02045	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MWM06_RS02060	COG0142	geranyltranstransferase activity
MWM06_RS02070	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MWM06_RS02090	COG1028	Short-chain dehydrogenase reductase Sdr
MWM06_RS02095	COG0492	ferredoxin-NADP+ reductase activity
MWM06_RS02105	COG0792	nuclease activity
MWM06_RS02110	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MWM06_RS02125	COG1175	transmembrane transport
MWM06_RS02130	COG0395	ABC-type sugar transport system, permease component
MWM06_RS02160	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MWM06_RS02165	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MWM06_RS02170	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MWM06_RS02175	COG0805	protein transport
MWM06_RS02180	COG1605	Chorismate mutase
MWM06_RS02180	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MWM06_RS02190	COG3573	Dehydrogenase
MWM06_RS02240	COG1063	alcohol dehydrogenase
MWM06_RS02270	COG2255	four-way junction helicase activity
MWM06_RS02275	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MWM06_RS02280	COG0564	pseudouridine synthase activity
MWM06_RS02290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MWM06_RS02295	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MWM06_RS02300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MWM06_RS02305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MWM06_RS02315	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MWM06_RS02320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MWM06_RS02325	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MWM06_RS02370	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MWM06_RS02375	COG0131	Imidazoleglycerol-phosphate dehydratase
MWM06_RS02380	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MWM06_RS02385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MWM06_RS02390	COG0517	IMP dehydrogenase activity
MWM06_RS02390	COG0516	GMP reductase activity
MWM06_RS02405	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MWM06_RS02420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MWM06_RS02445	COG0706	membrane insertase activity
MWM06_RS02450	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MWM06_RS02455	COG0594	ribonuclease P activity
MWM06_RS02460	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MWM06_RS02470	COG1022	Amp-dependent synthetase and ligase
MWM06_RS02510	COG1121	(ABC) transporter
MWM06_RS02515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MWM06_RS02520	COG1959	2 iron, 2 sulfur cluster binding
MWM06_RS02525	COG1104	cysteine desulfurase activity
MWM06_RS02530	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MWM06_RS02535	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MWM06_RS02550	COG1028	Short-chain dehydrogenase reductase Sdr
MWM06_RS02575	COG0492	ferredoxin-NADP+ reductase activity
MWM06_RS02580	COG1028	Short-chain dehydrogenase reductase Sdr
MWM06_RS02580	COG3321	synthase
MWM06_RS02580	COG0604	alcohol dehydrogenase
MWM06_RS02585	COG0747	negative chemotaxis
MWM06_RS02590	COG0601	transmembrane transport
MWM06_RS02595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MWM06_RS02610	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MWM06_RS02610	COG0617	tRNA 3'-terminal CCA addition
MWM06_RS02610	COG0517	IMP dehydrogenase activity
MWM06_RS02615	COG0123	including yeast histone deacetylase and acetoin utilization protein
MWM06_RS02620	COG2104	thiamine diphosphate biosynthetic process
MWM06_RS02625	COG0037	tRNA processing
MWM06_RS02635	COG0366	Alpha amylase catalytic
MWM06_RS02640	COG2226	methyltransferase
MWM06_RS02645	COG2226	methyltransferase
MWM06_RS02655	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MWM06_RS02665	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MWM06_RS02670	COG3744	PilT protein domain protein
MWM06_RS02680	COG0460	homoserine dehydrogenase
MWM06_RS02690	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MWM06_RS02735	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MWM06_RS02750	COG0247	lactate metabolic process
MWM06_RS02755	COG0277	FAD linked oxidase domain protein
MWM06_RS02760	COG0277	FAD linked oxidase domain protein
MWM06_RS02765	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MWM06_RS02770	COG1414	Transcriptional regulator
MWM06_RS02775	COG0789	Transcriptional regulator
MWM06_RS02785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MWM06_RS02790	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
MWM06_RS02825	COG0861	Integral membrane protein TerC family
MWM06_RS02830	COG2151	metal-sulfur cluster biosynthetic enzyme
MWM06_RS02835	COG0281	malic enzyme
MWM06_RS02850	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MWM06_RS02855	COG0509	glycine decarboxylation via glycine cleavage system
MWM06_RS02860	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MWM06_RS02865	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MWM06_RS02870	COG0196	riboflavin kinase activity
MWM06_RS02895	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MWM06_RS02900	COG2813	Specifically methylates the guanine in position
MWM06_RS02905	COG0527	aspartate kinase activity
MWM06_RS02935	COG4956	integral membrane protein (PIN domain superfamily)
MWM06_RS02940	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MWM06_RS02945	COG0542	response to heat
MWM06_RS02950	COG0423	glycine-tRNA ligase activity
MWM06_RS02960	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MWM06_RS02980	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MWM06_RS02980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MWM06_RS02990	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MWM06_RS03000	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MWM06_RS03010	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MWM06_RS03015	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MWM06_RS03020	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MWM06_RS03025	COG0114	fumarate hydratase activity
MWM06_RS03030	COG0183	Belongs to the thiolase family
MWM06_RS03045	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MWM06_RS03050	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MWM06_RS03065	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MWM06_RS03070	COG1254	Belongs to the acylphosphatase family
MWM06_RS03090	COG3335	DDE superfamily endonuclease
MWM06_RS03100	COG2133	pyrroloquinoline quinone binding
MWM06_RS03110	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MWM06_RS03115	COG0154	amidase activity
MWM06_RS03140	COG0572	uridine kinase
MWM06_RS03145	COG3842	ATPase activity
MWM06_RS03160	COG4475	Protein of unknown function (DUF436)
MWM06_RS03190	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MWM06_RS03195	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MWM06_RS03200	COG0803	Belongs to the bacterial solute-binding protein 9 family
MWM06_RS03215	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MWM06_RS03220	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MWM06_RS03225	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MWM06_RS03230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MWM06_RS03240	COG0318	PFAM AMP-dependent synthetase and ligase
MWM06_RS03255	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MWM06_RS03260	COG1293	RNA-binding protein homologous to eukaryotic snRNP
MWM06_RS03265	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MWM06_RS03275	COG3870	Protein conserved in bacteria
MWM06_RS03280	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MWM06_RS03300	COG0544	peptidyl-prolyl cis-trans isomerase activity
MWM06_RS03305	COG0740	serine-type endopeptidase activity
MWM06_RS03310	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MWM06_RS03315	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MWM06_RS03320	COG0646	methionine synthase
MWM06_RS03320	COG1410	methionine synthase
MWM06_RS03330	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MWM06_RS03355	COG1692	metallophosphoesterase
MWM06_RS03360	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MWM06_RS03365	COG1970	mechanosensitive ion channel activity
MWM06_RS03430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MWM06_RS03440	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MWM06_RS03445	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MWM06_RS03500	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MWM06_RS03510	COG1215	transferase activity, transferring glycosyl groups
MWM06_RS03520	COG1216	Glycosyl transferase, family 2
MWM06_RS03535	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MWM06_RS03555	COG0489	protein tyrosine kinase activity
MWM06_RS03565	COG2264	protein methyltransferase activity
MWM06_RS03570	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MWM06_RS03605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MWM06_RS03610	COG2046	Belongs to the sulfate adenylyltransferase family
MWM06_RS03615	COG1648	precorrin-2 dehydrogenase activity
MWM06_RS03615	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MWM06_RS03620	COG0730	response to heat
MWM06_RS03625	COG0175	sulfate reduction
MWM06_RS03630	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MWM06_RS03630	COG1648	precorrin-2 dehydrogenase activity
MWM06_RS03635	COG1587	Uroporphyrinogen-III synthase
MWM06_RS03640	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MWM06_RS03650	COG0352	thiamine-phosphate diphosphorylase activity
MWM06_RS03655	COG2104	thiamine diphosphate biosynthetic process
MWM06_RS03660	COG2022	thiamine diphosphate biosynthetic process
MWM06_RS03665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MWM06_RS03665	COG2022	thiamine diphosphate biosynthetic process
MWM06_RS03670	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MWM06_RS03675	COG0477	Major facilitator Superfamily
MWM06_RS03680	COG0351	phosphomethylpyrimidine kinase
MWM06_RS03710	COG1175	transmembrane transport
MWM06_RS03720	COG1940	carbohydrate kinase activity
MWM06_RS03725	COG0183	Belongs to the thiolase family
MWM06_RS03740	COG1028	Short-chain dehydrogenase reductase Sdr
MWM06_RS03760	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MWM06_RS03760	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MWM06_RS03770	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MWM06_RS03780	COG0195	Participates in both transcription termination and antitermination
MWM06_RS03785	COG0779	Required for maturation of 30S ribosomal subunits
MWM06_RS03795	COG0739	heme binding
MWM06_RS03800	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MWM06_RS03805	COG0640	Transcriptional regulator
MWM06_RS03810	COG2217	Heavy metal translocating P-type atpase
MWM06_RS03815	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MWM06_RS03820	COG0017	Asparaginyl-tRNA synthetase
MWM06_RS03825	COG0561	phosphatase activity
MWM06_RS03830	COG0384	phenazine biosynthesis protein PhzF
MWM06_RS03840	COG0124	histidyl-tRNA synthetase
MWM06_RS03850	COG3842	ATPase activity
MWM06_RS03865	COG1573	uracil-dna glycosylase
MWM06_RS03885	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MWM06_RS03900	COG1316	TRANSCRIPTIONal
MWM06_RS03910	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MWM06_RS03955	COG0295	cytidine deaminase activity
MWM06_RS03965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MWM06_RS03985	COG0481	GTPase activity
MWM06_RS03995	COG0463	Glycosyl transferase, family 2
MWM06_RS04010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MWM06_RS04055	COG0405	Gamma-glutamyltransferase
MWM06_RS04075	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MWM06_RS04080	COG2873	o-acetylhomoserine
MWM06_RS04095	COG1063	alcohol dehydrogenase
MWM06_RS04110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MWM06_RS04115	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MWM06_RS04120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MWM06_RS04125	COG1116	anion transmembrane transporter activity
MWM06_RS04125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MWM06_RS04130	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MWM06_RS04140	COG0167	dihydroorotate dehydrogenase activity
MWM06_RS04155	COG0540	Belongs to the ATCase OTCase family
MWM06_RS04160	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MWM06_RS04170	COG0730	response to heat
MWM06_RS04175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MWM06_RS04185	COG1960	acyl-CoA dehydrogenase activity
MWM06_RS04190	COG0456	acetyltransferase
MWM06_RS04200	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MWM06_RS04205	COG0009	L-threonylcarbamoyladenylate synthase
MWM06_RS04210	COG1459	type II secretion system
MWM06_RS04225	COG0277	FAD linked oxidase domain protein
MWM06_RS04245	COG0287	Prephenate dehydrogenase
MWM06_RS04250	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MWM06_RS04255	COG2514	catechol 2,3-dioxygenase activity
MWM06_RS04260	COG2353	YceI-like domain
MWM06_RS04265	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
MWM06_RS04270	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MWM06_RS04300	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MWM06_RS04305	COG0179	Fumarylacetoacetate (FAA) hydrolase
MWM06_RS04315	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MWM06_RS04320	COG0151	Belongs to the GarS family
MWM06_RS04325	COG2176	DNA-directed DNA polymerase activity
MWM06_RS04325	COG5002	protein histidine kinase activity
MWM06_RS04355	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MWM06_RS04365	COG0217	transcriptional regulatory protein
MWM06_RS04370	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MWM06_RS04370	COG4651	solute:proton antiporter activity
MWM06_RS04375	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MWM06_RS04380	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MWM06_RS04385	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MWM06_RS04390	COG1674	ftsk spoiiie
MWM06_RS04405	COG0517	IMP dehydrogenase activity
MWM06_RS04420	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MWM06_RS04420	COG3620	sequence-specific DNA binding
MWM06_RS04420	COG0617	tRNA 3'-terminal CCA addition
MWM06_RS04430	COG1994	Peptidase M50
MWM06_RS04435	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MWM06_RS04445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MWM06_RS04460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MWM06_RS04470	COG2719	SpoVR family
MWM06_RS04475	COG2718	Belongs to the UPF0229 family
MWM06_RS04480	COG2766	serine protein kinase
MWM06_RS04505	COG2137	regulation of response to DNA damage stimulus
MWM06_RS04515	COG2359	stage V sporulation protein S
MWM06_RS04520	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MWM06_RS04525	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MWM06_RS04535	COG0463	Glycosyl transferase, family 2
MWM06_RS04540	COG0750	zinc metalloprotease
MWM06_RS04545	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MWM06_RS04550	COG4589	Belongs to the CDS family
MWM06_RS04555	COG0233	cytoplasmic translational termination
MWM06_RS04560	COG0528	UMP kinase activity
MWM06_RS04565	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MWM06_RS04570	COG0052	Belongs to the universal ribosomal protein uS2 family
MWM06_RS04580	COG0582	viral genome integration into host DNA
MWM06_RS04650	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MWM06_RS04655	COG0494	nUDIX hydrolase
MWM06_RS04685	COG0402	S-adenosylhomocysteine deaminase activity
MWM06_RS04695	COG4948	Mandelate Racemase Muconate Lactonizing
MWM06_RS04700	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MWM06_RS04705	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MWM06_RS04710	COG1811	Na channel or pump
MWM06_RS04715	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MWM06_RS04715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MWM06_RS04730	COG1215	transferase activity, transferring glycosyl groups
MWM06_RS04740	COG1215	transferase activity, transferring glycosyl groups
MWM06_RS04750	COG0438	transferase activity, transferring glycosyl groups
MWM06_RS04755	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
MWM06_RS04770	COG1024	Enoyl-CoA hydratase
MWM06_RS04770	COG1250	3-hydroxyacyl-CoA dehydrogenase
MWM06_RS04775	COG0183	Belongs to the thiolase family
MWM06_RS04780	COG1960	acyl-CoA dehydrogenase activity
MWM06_RS04785	COG0215	cysteine-tRNA ligase activity
MWM06_RS04790	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MWM06_RS04800	COG2738	Putative neutral zinc metallopeptidase
MWM06_RS04820	COG1196	nuclear chromosome segregation
MWM06_RS04835	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MWM06_RS04840	COG3153	acetyltransferase
MWM06_RS04840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MWM06_RS04845	COG1268	BioY protein
MWM06_RS04855	COG0126	phosphoglycerate kinase activity
MWM06_RS04860	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MWM06_RS04865	COG0824	Thioesterase
MWM06_RS04875	COG0557	exoribonuclease II activity
MWM06_RS04880	COG1355	regulation of microtubule-based process
MWM06_RS04885	COG0617	tRNA 3'-terminal CCA addition
MWM06_RS04885	COG1353	crispr-associated protein
MWM06_RS04890	COG0237	dephospho-CoA kinase activity
MWM06_RS04905	COG0742	ribosomal rna small subunit methyltransferase
MWM06_RS04910	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MWM06_RS04915	COG0138	bifunctional purine biosynthesis protein purh
MWM06_RS04920	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MWM06_RS04935	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MWM06_RS05015	COG0149	triose-phosphate isomerase activity
MWM06_RS05020	COG3239	Fatty acid desaturase
MWM06_RS05025	COG1490	D-aminoacyl-tRNA deacylase activity
MWM06_RS05030	COG1307	EDD domain protein, DegV family
MWM06_RS05035	COG1307	EDD domain protein, DegV family
MWM06_RS05040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MWM06_RS05055	COG3769	mannosylglycerate metabolic process
MWM06_RS05065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MWM06_RS05075	COG1012	belongs to the aldehyde dehydrogenase family
MWM06_RS05185	COG0629	single-stranded DNA binding
MWM06_RS05235	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MWM06_RS05300	COG3854	ATPases associated with a variety of cellular activities
MWM06_RS05485	COG2165	general secretion pathway protein
MWM06_RS05680	COG0588	phosphoglycerate mutase activity
MWM06_RS05700	COG1028	Short-chain dehydrogenase reductase Sdr
MWM06_RS05710	COG1012	belongs to the aldehyde dehydrogenase family
MWM06_RS05710	COG2030	dehydratase
MWM06_RS05715	COG1028	Short-chain dehydrogenase reductase Sdr
MWM06_RS05725	COG1960	acyl-CoA dehydrogenase activity
MWM06_RS05755	COG2723	6-phospho-beta-galactosidase activity
MWM06_RS05760	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MWM06_RS05780	COG1233	COG1233 Phytoene dehydrogenase and related
MWM06_RS05785	COG0702	epimerase
MWM06_RS05815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MWM06_RS05830	COG1562	ergosterol biosynthetic process
MWM06_RS05840	COG2124	cytochrome p450
MWM06_RS05875	COG1487	ribonuclease activity
MWM06_RS05885	COG1304	FMN binding
MWM06_RS05905	COG1085	galactose-1-phosphate uridylyltransferase
MWM06_RS05910	COG3345	alpha-galactosidase
MWM06_RS05930	COG1475	DNA binding
MWM06_RS05935	COG1192	Involved in chromosome partitioning
MWM06_RS05955	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MWM06_RS06010	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MWM06_RS06015	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MWM06_RS06020	COG1252	NADH dehydrogenase
MWM06_RS06045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MWM06_RS06075	COG2151	metal-sulfur cluster biosynthetic enzyme
MWM06_RS06085	COG0584	glycerophosphoryl diester phosphodiesterase
MWM06_RS06095	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MWM06_RS06110	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MWM06_RS06125	COG1337	RAMP superfamily
MWM06_RS06190	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MWM06_RS06340	COG3335	DDE superfamily endonuclease
MWM06_RS06370	COG3396	Phenylacetate-CoA oxygenase
MWM06_RS06380	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
MWM06_RS06395	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MWM06_RS06400	COG1607	acyl-coa hydrolase
MWM06_RS06410	COG1980	fructose-bisphosphate aldolase activity
MWM06_RS06415	COG1733	regulation of RNA biosynthetic process
MWM06_RS06420	COG2193	ferroxidase activity
MWM06_RS06425	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MWM06_RS06430	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MWM06_RS06450	COG1331	Highly conserved protein containing a thioredoxin domain
MWM06_RS06455	COG0183	Belongs to the thiolase family
MWM06_RS06490	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MWM06_RS06490	COG2199	diguanylate cyclase activity
MWM06_RS06495	COG1012	belongs to the aldehyde dehydrogenase family
MWM06_RS06510	COG0210	DNA helicase
MWM06_RS06535	COG0745	RESPONSE REGULATOR receiver
MWM06_RS06540	COG2205	protein histidine kinase activity
MWM06_RS06560	COG1136	(ABC) transporter
MWM06_RS06565	COG0577	efflux transmembrane transporter activity
MWM06_RS06565	COG1136	(ABC) transporter
MWM06_RS06645	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MWM06_RS06695	COG0582	viral genome integration into host DNA
MWM06_RS06710	COG2897	thiosulfate sulfurtransferase activity
MWM06_RS06715	COG1760	l-serine dehydratase
MWM06_RS06720	COG2197	response regulator
MWM06_RS06725	COG0335	large ribosomal subunit rRNA binding
MWM06_RS06730	COG0336	Belongs to the RNA methyltransferase TrmD family
MWM06_RS06735	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MWM06_RS06740	COG1837	Belongs to the UPF0109 family
MWM06_RS06745	COG0228	four-way junction DNA binding
MWM06_RS06760	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MWM06_RS06765	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MWM06_RS06765	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MWM06_RS06770	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MWM06_RS06780	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MWM06_RS06790	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MWM06_RS06795	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MWM06_RS06800	COG1702	phosphate starvation-inducible protein PhoH
MWM06_RS06810	COG4864	UPF0365 protein
MWM06_RS06825	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MWM06_RS06845	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MWM06_RS06845	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MWM06_RS06865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MWM06_RS06875	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MWM06_RS06880	COG1397	ADP-ribosylglycohydrolase
MWM06_RS06885	COG2239	Acts as a magnesium transporter
MWM06_RS06890	COG2304	oxidoreductase activity
MWM06_RS06895	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MWM06_RS06895	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MWM06_RS06905	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MWM06_RS06905	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MWM06_RS06910	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MWM06_RS06915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MWM06_RS06920	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MWM06_RS06925	COG0006	proline dipeptidase activity
MWM06_RS06935	COG0739	heme binding
MWM06_RS06945	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MWM06_RS06950	COG0254	rRNA binding
MWM06_RS07070	COG4383	Mu-like prophage protein gp29
MWM06_RS07200	COG4397	Mu-like prophage major head subunit gpT
MWM06_RS07210	COG5005	Phage virion morphogenesis
MWM06_RS07240	COG2001	Belongs to the MraZ family
MWM06_RS07245	COG0275	rRNA processing
MWM06_RS07255	COG0768	penicillin binding
MWM06_RS07260	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MWM06_RS07270	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MWM06_RS07275	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MWM06_RS07280	COG0772	Belongs to the SEDS family
MWM06_RS07285	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MWM06_RS07290	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MWM06_RS07295	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MWM06_RS07315	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MWM06_RS07335	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MWM06_RS07345	COG0159	tryptophan synthase activity
MWM06_RS07350	COG0133	tryptophan synthase activity
MWM06_RS07355	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
MWM06_RS07360	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MWM06_RS07365	COG1744	ABC transporter substrate-binding protein PnrA-like
MWM06_RS07370	COG3845	ABC transporter
MWM06_RS07420	COG0438	transferase activity, transferring glycosyl groups
MWM06_RS07425	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MWM06_RS07435	COG0039	L-malate dehydrogenase activity
MWM06_RS07440	COG2819	hydrolase of the alpha beta superfamily
MWM06_RS07455	COG0247	lactate metabolic process
MWM06_RS07455	COG2181	nitrate reductase activity
MWM06_RS07465	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
MWM06_RS07470	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MWM06_RS07475	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MWM06_RS07485	COG0439	Biotin carboxylase
MWM06_RS07490	COG0511	ligase activity, forming carbon-carbon bonds
MWM06_RS07495	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MWM06_RS07515	COG0010	Belongs to the arginase family
MWM06_RS07530	COG1100	Small GTP-binding protein
MWM06_RS07540	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MWM06_RS07545	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MWM06_RS07565	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MWM06_RS07570	COG1185	polyribonucleotide nucleotidyltransferase activity
MWM06_RS07575	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MWM06_RS07580	COG0589	response to stress
MWM06_RS07590	COG2239	Acts as a magnesium transporter
MWM06_RS07595	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MWM06_RS07600	COG0745	RESPONSE REGULATOR receiver
MWM06_RS07605	COG5002	protein histidine kinase activity
MWM06_RS07610	COG1960	acyl-CoA dehydrogenase activity
MWM06_RS07615	COG2086	electron transfer activity
MWM06_RS07620	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MWM06_RS07630	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MWM06_RS07635	COG1573	uracil-dna glycosylase
MWM06_RS07640	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MWM06_RS07640	COG1796	DNA polymerase
MWM06_RS07650	COG2309	aminopeptidase activity
MWM06_RS07665	COG2873	o-acetylhomoserine
MWM06_RS07670	COG2358	TRAP transporter, solute receptor (TAXI family
MWM06_RS07680	COG1126	abc transporter atp-binding protein
MWM06_RS07690	COG1752	Esterase of the alpha-beta hydrolase superfamily
MWM06_RS07695	COG3311	Transcriptional regulator
MWM06_RS07705	COG0134	indole-3-glycerol-phosphate synthase activity
MWM06_RS07710	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MWM06_RS07720	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MWM06_RS07735	COG0765	amino acid transport
MWM06_RS07750	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MWM06_RS07755	COG0569	domain protein
MWM06_RS07760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MWM06_RS07765	COG1426	Protein conserved in bacteria
MWM06_RS07770	COG2313	pseudouridylate synthase activity
MWM06_RS07780	COG3001	Fructosamine kinase
MWM06_RS07785	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MWM06_RS07795	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
MWM06_RS07820	COG0012	GTP binding
MWM06_RS07825	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MWM06_RS07835	COG0424	maF-like protein
MWM06_RS07850	COG0768	penicillin binding
MWM06_RS07855	COG0850	regulation of cytokinetic process
MWM06_RS07880	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MWM06_RS07885	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MWM06_RS07895	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MWM06_RS07910	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MWM06_RS07940	COG1131	(ABC) transporter
MWM06_RS07955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MWM06_RS07970	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MWM06_RS07975	COG0440	acetolactate synthase activity
MWM06_RS07980	COG0028	Belongs to the TPP enzyme family
MWM06_RS07985	COG0492	ferredoxin-NADP+ reductase activity
MWM06_RS07995	COG4970	Tfp pilus assembly protein FimT
MWM06_RS08015	COG2165	general secretion pathway protein
MWM06_RS08050	COG0180	Tryptophanyl-tRNA synthetase
MWM06_RS08055	COG0544	peptidyl-prolyl cis-trans isomerase activity
MWM06_RS08060	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MWM06_RS08065	COG0066	3-isopropylmalate dehydratase activity
MWM06_RS08070	COG0473	3-isopropylmalate dehydrogenase activity
MWM06_RS08085	COG0300	oxidoreductase activity
MWM06_RS08090	COG0129	dihydroxy-acid dehydratase activity
MWM06_RS08100	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MWM06_RS08105	COG1177	transmembrane transport
MWM06_RS08110	COG1176	ABC-type spermidine putrescine transport system, permease component I
MWM06_RS08115	COG3842	ATPase activity
MWM06_RS08120	COG0772	Belongs to the SEDS family
MWM06_RS08125	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
MWM06_RS08130	COG2894	cell division
MWM06_RS08135	COG1733	regulation of RNA biosynthetic process
MWM06_RS08145	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MWM06_RS08145	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MWM06_RS08155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MWM06_RS08160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MWM06_RS08185	COG0653	protein targeting
MWM06_RS08190	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MWM06_RS08210	COG0393	Putative heavy-metal-binding
MWM06_RS08215	COG1111	helicase
MWM06_RS08215	COG1205	dead DEAH box helicase
MWM06_RS08230	COG0358	DNA primase activity
MWM06_RS08240	COG1250	3-hydroxyacyl-CoA dehydrogenase
MWM06_RS08245	COG0697	spore germination
MWM06_RS08250	COG0612	Peptidase, M16
MWM06_RS08255	COG0612	Peptidase, M16
MWM06_RS08260	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MWM06_RS08275	COG1394	ATPase activity, coupled to movement of substances
MWM06_RS08280	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
MWM06_RS08285	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
MWM06_RS08290	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
MWM06_RS08295	COG1527	subunit (C
MWM06_RS08300	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
MWM06_RS08310	COG1269	ATP hydrolysis coupled proton transport
MWM06_RS08335	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MWM06_RS08345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MWM06_RS08360	COG0419	ATPase involved in DNA repair
MWM06_RS08365	COG0420	3'-5' exonuclease activity
MWM06_RS08385	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MWM06_RS08390	COG2884	Cell division ATP-binding protein ftsE
MWM06_RS08395	COG0793	Belongs to the peptidase S41A family
MWM06_RS08410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MWM06_RS08410	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MWM06_RS08415	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MWM06_RS08420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MWM06_RS08430	COG1079	Belongs to the binding-protein-dependent transport system permease family
MWM06_RS08435	COG4603	Belongs to the binding-protein-dependent transport system permease family
MWM06_RS08440	COG1129	ABC transporter
MWM06_RS08445	COG0746	molybdenum cofactor guanylyltransferase activity
MWM06_RS08460	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MWM06_RS08480	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MWM06_RS08485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MWM06_RS08490	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MWM06_RS08500	COG1994	Peptidase M50
MWM06_RS08500	COG0517	IMP dehydrogenase activity
MWM06_RS08505	COG2358	TRAP transporter, solute receptor (TAXI family
MWM06_RS08515	COG2358	TRAP transporter, solute receptor (TAXI family
MWM06_RS08530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MWM06_RS08535	COG0788	formyltetrahydrofolate deformylase activity
MWM06_RS08540	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MWM06_RS08545	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MWM06_RS08550	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MWM06_RS08560	COG2010	Cytochrome c
MWM06_RS08570	COG0737	Belongs to the 5'-nucleotidase family
MWM06_RS08575	COG0174	glutamine synthetase
MWM06_RS08585	COG0559	Belongs to the binding-protein-dependent transport system permease family
MWM06_RS08605	COG0747	negative chemotaxis
MWM06_RS08610	COG0601	transmembrane transport
MWM06_RS08615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MWM06_RS08625	COG0285	dihydrofolate synthase activity
MWM06_RS08630	COG1132	(ABC) transporter
MWM06_RS08635	COG1132	(ABC) transporter
MWM06_RS08640	COG0372	Belongs to the citrate synthase family
MWM06_RS08645	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MWM06_RS08650	COG1482	cell wall glycoprotein biosynthetic process
MWM06_RS08660	COG1515	deoxyribonuclease V activity
MWM06_RS08670	COG0776	regulation of translation
MWM06_RS08685	COG2197	response regulator
MWM06_RS08690	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MWM06_RS08695	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MWM06_RS08700	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MWM06_RS08705	COG1324	tolerance protein
MWM06_RS08720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MWM06_RS08740	COG2205	protein histidine kinase activity
MWM06_RS08755	COG0247	lactate metabolic process
MWM06_RS08760	COG1139	Iron-sulfur cluster binding protein
MWM06_RS08765	COG1556	Lactate utilization protein
MWM06_RS08775	COG1752	Esterase of the alpha-beta hydrolase superfamily
MWM06_RS08780	COG0515	serine threonine protein kinase
MWM06_RS08780	COG2815	serine threonine protein kinase
MWM06_RS08790	COG0860	N-Acetylmuramoyl-L-alanine amidase
MWM06_RS08800	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MWM06_RS08840	COG0473	3-isopropylmalate dehydrogenase activity
MWM06_RS08865	COG1450	Type ii and iii secretion system protein
MWM06_RS08870	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MWM06_RS08875	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MWM06_RS08880	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MWM06_RS08885	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MWM06_RS08885	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
MWM06_RS08890	COG0736	holo-[acyl-carrier-protein] synthase activity
MWM06_RS08905	COG1160	GTP binding
MWM06_RS08910	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MWM06_RS08915	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MWM06_RS08915	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MWM06_RS08920	COG0083	homoserine kinase activity
MWM06_RS08935	COG0268	Binds directly to 16S ribosomal RNA
MWM06_RS08945	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MWM06_RS08950	COG0723	plastoquinol--plastocyanin reductase activity
MWM06_RS08960	COG3088	subunit of a heme lyase
MWM06_RS08960	COG4235	cytochrome complex assembly
MWM06_RS08965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MWM06_RS08970	COG1138	Cytochrome C-type biogenesis protein
MWM06_RS08975	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
MWM06_RS08980	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MWM06_RS08985	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MWM06_RS08990	COG4133	protoheme IX ABC transporter activity
MWM06_RS08995	COG0785	Cytochrome C biogenesis protein
MWM06_RS09000	COG3258	Cytochrome c
MWM06_RS09010	COG0446	pyridine nucleotide-disulphide oxidoreductase
MWM06_RS09025	COG3258	Cytochrome c
MWM06_RS09030	COG2010	Cytochrome c
MWM06_RS09035	COG0737	Belongs to the 5'-nucleotidase family
MWM06_RS09040	COG2010	Cytochrome c
MWM06_RS09045	COG3258	Cytochrome c
MWM06_RS09065	COG2010	Cytochrome c
MWM06_RS09070	COG3842	ATPase activity
MWM06_RS09100	COG0318	PFAM AMP-dependent synthetase and ligase
MWM06_RS09105	COG3360	Dodecin
MWM06_RS09120	COG1024	Enoyl-CoA hydratase
MWM06_RS09125	COG0813	purine-nucleoside phosphorylase activity
MWM06_RS09130	COG1136	(ABC) transporter
MWM06_RS09135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MWM06_RS09140	COG2045	Belongs to the ComB family
MWM06_RS09150	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MWM06_RS09160	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
MWM06_RS09170	COG0107	imidazoleglycerol-phosphate synthase activity
MWM06_RS09175	COG0140	phosphoribosyl-ATP diphosphatase activity
MWM06_RS09175	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MWM06_RS09180	COG1494	fructose-1,6-bisphosphatase
MWM06_RS09185	COG0686	Belongs to the AlaDH PNT family
MWM06_RS09190	COG0427	acetyl-CoA hydrolase
MWM06_RS09195	COG0084	hydrolase, TatD family'
MWM06_RS09200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MWM06_RS09210	COG0017	Asparaginyl-tRNA synthetase
MWM06_RS09215	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MWM06_RS09230	COG2009	succinate dehydrogenase
MWM06_RS09235	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MWM06_RS09265	COG0318	PFAM AMP-dependent synthetase and ligase
MWM06_RS09270	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MWM06_RS09275	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MWM06_RS09280	COG0504	CTP synthase activity
MWM06_RS09295	COG0070	glutamate synthase
MWM06_RS09295	COG0067	glutamate synthase
MWM06_RS09295	COG0069	glutamate synthase activity
MWM06_RS09300	COG0840	transmembrane signaling receptor activity
MWM06_RS09305	COG0305	Participates in initiation and elongation during chromosome replication
MWM06_RS09315	COG0475	glutathione-regulated potassium exporter activity
MWM06_RS09320	COG0517	IMP dehydrogenase activity
MWM06_RS09320	COG0617	tRNA 3'-terminal CCA addition
MWM06_RS09320	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MWM06_RS09335	COG0475	glutathione-regulated potassium exporter activity
MWM06_RS09340	COG0490	domain, Protein
MWM06_RS09360	COG3118	belongs to the thioredoxin family
MWM06_RS09390	COG0542	response to heat
MWM06_RS09395	COG0789	Transcriptional regulator
MWM06_RS09400	COG0484	heat shock protein binding
MWM06_RS09405	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MWM06_RS09410	COG0443	Heat shock 70 kDa protein
MWM06_RS09415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MWM06_RS09420	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MWM06_RS09425	COG0616	signal peptide processing
MWM06_RS09440	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
MWM06_RS09445	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MWM06_RS09450	COG0714	Associated with various cellular activities
MWM06_RS09455	COG0574	Belongs to the PEP-utilizing enzyme family
MWM06_RS09455	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MWM06_RS09460	COG1272	protein, Hemolysin III
MWM06_RS09470	COG3850	Histidine kinase
MWM06_RS09470	COG5002	protein histidine kinase activity
MWM06_RS09485	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MWM06_RS09500	COG1011	Hydrolase
MWM06_RS09525	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MWM06_RS09540	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MWM06_RS09550	COG0047	phosphoribosylformylglycinamidine synthase activity
MWM06_RS09560	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MWM06_RS09565	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MWM06_RS09575	COG0116	Belongs to the methyltransferase superfamily
MWM06_RS09590	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MWM06_RS09595	COG0497	DNA recombination
MWM06_RS09605	COG0604	alcohol dehydrogenase
MWM06_RS09625	COG0585	pseudouridine synthase activity
MWM06_RS09640	COG0557	exoribonuclease II activity
MWM06_RS09645	COG0538	isocitrate dehydrogenase activity
MWM06_RS09670	COG4974	Belongs to the 'phage' integrase family
MWM06_RS09685	COG0037	tRNA processing
MWM06_RS09685	COG0590	tRNA wobble adenosine to inosine editing
MWM06_RS09710	COG2050	protein possibly involved in aromatic compounds catabolism
MWM06_RS09720	COG0322	excinuclease ABC activity
MWM06_RS09725	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MWM06_RS09730	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MWM06_RS09735	COG1854	S-ribosylhomocysteine lyase activity
MWM06_RS09740	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MWM06_RS09740	COG0519	Catalyzes the synthesis of GMP from XMP
MWM06_RS09750	COG4274	PFAM GYD family protein
MWM06_RS09760	COG0328	RNA-DNA hybrid ribonuclease activity
MWM06_RS09765	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MWM06_RS09770	COG2095	MarC family integral membrane protein
MWM06_RS09775	COG1438	arginine binding
MWM06_RS09780	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MWM06_RS09785	COG1758	RNA polymerase activity
MWM06_RS09790	COG0194	GDP metabolic process
MWM06_RS09800	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MWM06_RS09805	COG2385	sporulation resulting in formation of a cellular spore
MWM06_RS09810	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
MWM06_RS09820	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
MWM06_RS09850	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MWM06_RS09855	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MWM06_RS09860	COG1012	belongs to the aldehyde dehydrogenase family
MWM06_RS09865	COG0506	proline dehydrogenase activity
MWM06_RS09885	COG0156	8-amino-7-oxononanoate synthase activity
MWM06_RS09890	COG0827	DNA restriction-modification system
MWM06_RS09890	COG0732	type I restriction modification DNA specificity domain
MWM06_RS09905	COG0187	DNA topoisomerase II activity
MWM06_RS09910	COG1181	Belongs to the D-alanine--D-alanine ligase family
MWM06_RS09915	COG0193	aminoacyl-tRNA hydrolase activity
MWM06_RS09920	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MWM06_RS09935	COG0631	protein serine/threonine phosphatase activity
MWM06_RS09950	COG0113	porphobilinogen synthase activity
MWM06_RS09955	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MWM06_RS09960	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MWM06_RS09985	COG0823	Involved in the tonB-independent uptake of proteins
MWM06_RS09985	COG1506	peptidase
MWM06_RS09985	COG4946	Tricorn protease homolog
MWM06_RS09990	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MWM06_RS09995	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MWM06_RS10015	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MWM06_RS10020	COG1011	Hydrolase
MWM06_RS10045	COG0537	adenosine 5'-monophosphoramidase activity
MWM06_RS10050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MWM06_RS10060	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MWM06_RS10065	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MWM06_RS10070	COG0071	Belongs to the small heat shock protein (HSP20) family
MWM06_RS10075	COG2897	thiosulfate sulfurtransferase activity
MWM06_RS10080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MWM06_RS10090	COG1764	response to oxidative stress
MWM06_RS10105	COG1840	ABC-type Fe3 transport system, periplasmic component
MWM06_RS10115	COG3842	ATPase activity
MWM06_RS10120	COG0101	tRNA pseudouridine synthase activity
MWM06_RS10125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MWM06_RS10130	COG0601	transmembrane transport
MWM06_RS10145	COG0006	proline dipeptidase activity
MWM06_RS10150	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MWM06_RS10165	COG1166	arginine decarboxylase activity
MWM06_RS10170	COG3706	GGDEF domain
MWM06_RS10175	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MWM06_RS10180	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MWM06_RS10185	COG1611	Belongs to the LOG family
MWM06_RS10190	COG1193	negative regulation of DNA recombination
MWM06_RS10245	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MWM06_RS10250	COG0142	geranyltranstransferase activity
MWM06_RS10260	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
MWM06_RS10290	COG0203	ribosomal protein L17
MWM06_RS10295	COG0202	RNA polymerase activity
MWM06_RS10300	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MWM06_RS10305	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MWM06_RS10310	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MWM06_RS10320	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MWM06_RS10330	COG0563	adenylate kinase activity
MWM06_RS10335	COG0201	protein transport
MWM06_RS10360	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MWM06_RS10365	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MWM06_RS10370	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MWM06_RS10395	COG0255	Belongs to the universal ribosomal protein uL29 family
MWM06_RS10400	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MWM06_RS10405	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MWM06_RS10415	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MWM06_RS10420	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MWM06_RS10425	COG0089	rRNA binding
MWM06_RS10430	COG0088	Forms part of the polypeptide exit tunnel
MWM06_RS10440	COG0051	transcription antitermination factor activity, RNA binding
MWM06_RS10445	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MWM06_RS10455	COG0049	tRNA binding
MWM06_RS10470	COG0442	prolyl-tRNA aminoacylation
MWM06_RS10480	COG1115	amino acid carrier protein
MWM06_RS10500	COG1489	DNA binding
MWM06_RS10525	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MWM06_RS10545	COG0432	Pfam Uncharacterised protein family UPF0047
MWM06_RS10550	COG3253	May function as heme-dependent peroxidase
MWM06_RS10555	COG0668	transmembrane transport
MWM06_RS10565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MWM06_RS10570	COG2217	Heavy metal translocating P-type atpase
MWM06_RS10590	COG0745	RESPONSE REGULATOR receiver
MWM06_RS10595	COG2205	protein histidine kinase activity
MWM06_RS10620	COG2226	methyltransferase
MWM06_RS10645	COG2132	Multicopper oxidase
MWM06_RS10655	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MWM06_RS10660	COG0822	iron-sulfur transferase activity
MWM06_RS10680	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MWM06_RS10690	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MWM06_RS10695	COG0284	orotidine-5'-phosphate decarboxylase activity
MWM06_RS10705	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MWM06_RS10715	COG0416	fatty acid biosynthetic process
MWM06_RS10720	COG3118	belongs to the thioredoxin family
MWM06_RS10725	COG1185	polyribonucleotide nucleotidyltransferase activity
MWM06_RS10730	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MWM06_RS10740	COG0438	transferase activity, transferring glycosyl groups
MWM06_RS10760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MWM06_RS10775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MWM06_RS10780	COG3706	GGDEF domain
MWM06_RS10810	COG0437	4 iron, 4 sulfur cluster binding
MWM06_RS10825	COG0825	malonyl-CoA metabolic process
MWM06_RS10830	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MWM06_RS10870	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MWM06_RS10895	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MWM06_RS10900	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MWM06_RS10905	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MWM06_RS10910	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MWM06_RS10955	COG0315	cyclic pyranopterin monophosphate synthase activity
MWM06_RS10965	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MWM06_RS10980	COG1694	Mazg nucleotide pyrophosphohydrolase
MWM06_RS10985	COG1803	Methylglyoxal synthase
MWM06_RS10995	COG0301	tRNA thio-modification
MWM06_RS11000	COG0154	amidase activity
MWM06_RS11005	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MWM06_RS11040	COG2154	pterin-4-alpha-carbinolamine dehydratase
MWM06_RS11045	COG1607	acyl-coa hydrolase
MWM06_RS11055	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MWM06_RS11060	COG4149	molybdate abc transporter
MWM06_RS11080	COG0235	Class ii aldolase
MWM06_RS11085	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MWM06_RS11090	COG0085	RNA polymerase activity
MWM06_RS11100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MWM06_RS11105	COG1077	Cell shape determining protein MreB Mrl
MWM06_RS11110	COG1418	mRNA catabolic process
MWM06_RS11110	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MWM06_RS11115	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MWM06_RS11120	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MWM06_RS11125	COG1546	Belongs to the CinA family
MWM06_RS11125	COG1058	Belongs to the CinA family
MWM06_RS11130	COG0354	folic acid binding
MWM06_RS11145	COG4948	Mandelate Racemase Muconate Lactonizing
MWM06_RS11160	COG1175	transmembrane transport
MWM06_RS11170	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MWM06_RS11180	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MWM06_RS11190	COG1136	(ABC) transporter
MWM06_RS11190	COG0577	efflux transmembrane transporter activity
MWM06_RS11195	COG4181	ATPase activity
MWM06_RS11200	COG0446	pyridine nucleotide-disulphide oxidoreductase
MWM06_RS11215	COG0396	ATPase activity
MWM06_RS11220	COG0719	Fe-S assembly protein
MWM06_RS11225	COG0719	Fe-S assembly protein
MWM06_RS11230	COG2146	nitrite reductase [NAD(P)H] activity
MWM06_RS11240	COG0512	Glutamine amidotransferase of anthranilate synthase
MWM06_RS11245	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MWM06_RS11275	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MWM06_RS11280	COG2226	methyltransferase
MWM06_RS11285	COG4603	Belongs to the binding-protein-dependent transport system permease family
MWM06_RS11290	COG1079	Belongs to the binding-protein-dependent transport system permease family
MWM06_RS11305	COG1774	PSP1 C-terminal conserved region
MWM06_RS11310	COG0470	DNA polymerase III
MWM06_RS11330	COG0497	DNA recombination
MWM06_RS11345	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MWM06_RS11360	COG0302	gtp cyclohydrolase
MWM06_RS11385	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MWM06_RS11395	COG0395	ABC-type sugar transport system, permease component
MWM06_RS11410	COG1131	(ABC) transporter
MWM06_RS11430	COG0556	nucleotide-excision repair
MWM06_RS11435	COG0497	DNA recombination
MWM06_RS11440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MWM06_RS11450	COG0445	tRNA wobble uridine modification
MWM06_RS11475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MWM06_RS11475	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MWM06_RS11480	COG1543	Belongs to the glycosyl hydrolase 57 family
MWM06_RS11485	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MWM06_RS11490	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MWM06_RS11495	COG0189	ligase activity
MWM06_RS11510	COG0066	3-isopropylmalate dehydratase activity
MWM06_RS11515	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MWM06_RS11530	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MWM06_RS11535	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MWM06_RS11540	COG1960	acyl-CoA dehydrogenase activity
MWM06_RS11545	COG0163	prenyltransferase activity
MWM06_RS11590	COG4555	ABC transporter
MWM06_RS11600	COG2096	Adenosyltransferase
MWM06_RS11620	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MWM06_RS11625	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MWM06_RS11640	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MWM06_RS11645	COG0723	plastoquinol--plastocyanin reductase activity
MWM06_RS11670	COG1653	transport
MWM06_RS11675	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MWM06_RS11680	COG1960	acyl-CoA dehydrogenase activity
MWM06_RS11690	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MWM06_RS11740	COG3956	TIGRFAM MazG family protein
MWM06_RS11745	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
MWM06_RS11750	COG0693	protein deglycase activity
MWM06_RS11755	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MWM06_RS11765	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MWM06_RS11770	COG1937	Protein conserved in bacteria
MWM06_RS11780	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MWM06_RS11780	COG0674	pyruvate-flavodoxin oxidoreductase activity
MWM06_RS11785	COG1013	pyruvate-flavodoxin oxidoreductase activity
MWM06_RS11815	COG0205	6-phosphofructokinase activity
MWM06_RS11820	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MWM06_RS11830	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MWM06_RS11845	COG2333	competence protein COMEC
MWM06_RS11845	COG0658	competence protein
MWM06_RS11850	COG1475	DNA binding
MWM06_RS11855	COG1192	Involved in chromosome partitioning
MWM06_RS11860	COG0357	Ribosomal RNA small subunit methyltransferase G
MWM06_RS11870	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MWM06_RS11875	COG1653	transport
MWM06_RS11885	COG0395	ABC-type sugar transport system, permease component
MWM06_RS11890	COG1692	metallophosphoesterase
MWM06_RS11915	COG4778	phosphonate C-P lyase system protein PhnL
MWM06_RS11920	COG4107	phosphonate C-P lyase system protein PhnK
MWM06_RS11925	COG3627	carbon phosphorus lyase activity
MWM06_RS11945	COG3639	organic phosphonate transmembrane transporter activity
MWM06_RS11955	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
MWM06_RS12050	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MWM06_RS12055	COG1475	DNA binding
MWM06_RS12060	COG1192	Involved in chromosome partitioning
MWM06_RS12150	COG2385	sporulation resulting in formation of a cellular spore
MWM06_RS12160	COG3335	DDE superfamily endonuclease
MWM06_RS12260	COG2002	toxin-antitoxin pair type II binding
MWM06_RS12280	COG3335	DDE superfamily endonuclease
MWM06_RS12320	COG0803	Belongs to the bacterial solute-binding protein 9 family
MWM06_RS12345	COG0523	cobalamin synthesis protein
MWM06_RS12350	COG0521	Mo-molybdopterin cofactor biosynthetic process
MWM06_RS12380	COG0395	ABC-type sugar transport system, permease component
MWM06_RS12405	COG3335	DDE superfamily endonuclease
MWM06_RS12435	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MWM06_RS12440	COG1175	transmembrane transport
MWM06_RS12455	COG4143	(ABC) transporter
MWM06_RS12550	COG1192	Involved in chromosome partitioning
MWM06_RS12570	COG4974	Belongs to the 'phage' integrase family
MWM06_RS12750	COG3335	DDE superfamily endonuclease
MWM06_RS12770	COG3335	DDE superfamily endonuclease