locus-tag	class	description
THIAE_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THIAE_RS00020	COG0446	pyridine nucleotide-disulphide oxidoreductase
THIAE_RS00025	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THIAE_RS00030	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
THIAE_RS00035	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
THIAE_RS00040	COG0314	molybdopterin synthase activity
THIAE_RS00045	COG0303	'Molybdopterin
THIAE_RS00050	COG0315	cyclic pyranopterin monophosphate synthase activity
THIAE_RS00060	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
THIAE_RS00065	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
THIAE_RS00070	COG1854	S-ribosylhomocysteine lyase activity
THIAE_RS00100	COG2203	Gaf domain
THIAE_RS00100	COG5001	Diguanylate cyclase
THIAE_RS00100	COG4251	negative regulation of phosphorylation
THIAE_RS00100	COG3706	GGDEF domain
THIAE_RS00170	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THIAE_RS00175	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
THIAE_RS00180	COG1028	Short-chain dehydrogenase reductase Sdr
THIAE_RS00190	COG0563	adenylate kinase activity
THIAE_RS00205	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
THIAE_RS00210	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
THIAE_RS00215	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THIAE_RS00225	COG0513	Belongs to the DEAD box helicase family
THIAE_RS00255	COG1217	gtp-binding protein TYPA
THIAE_RS00265	COG2391	methyltransferase activity
THIAE_RS00270	COG0659	secondary active sulfate transmembrane transporter activity
THIAE_RS00285	COG1410	methionine synthase
THIAE_RS00285	COG0646	methionine synthase
THIAE_RS00300	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THIAE_RS00310	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THIAE_RS00315	COG1758	RNA polymerase activity
THIAE_RS00320	COG0668	transmembrane transport
THIAE_RS00325	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
THIAE_RS00330	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THIAE_RS00340	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
THIAE_RS00350	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
THIAE_RS00355	COG5001	Diguanylate cyclase
THIAE_RS00355	COG4251	negative regulation of phosphorylation
THIAE_RS00355	COG3706	GGDEF domain
THIAE_RS00355	COG2203	Gaf domain
THIAE_RS00370	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
THIAE_RS00370	COG0543	2 iron, 2 sulfur cluster binding
THIAE_RS00380	COG0788	formyltetrahydrofolate deformylase activity
THIAE_RS00385	COG1444	tRNA N-acetyltransferase activity
THIAE_RS00390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THIAE_RS00390	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
THIAE_RS00415	COG0446	pyridine nucleotide-disulphide oxidoreductase
THIAE_RS00430	COG2081	HI0933 family
THIAE_RS00445	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
THIAE_RS00445	COG0678	peroxiredoxin activity
THIAE_RS00455	COG1519	Transferase
THIAE_RS00460	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
THIAE_RS00465	COG1454	alcohol dehydrogenase
THIAE_RS00470	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THIAE_RS00475	COG0194	GDP metabolic process
THIAE_RS00480	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
THIAE_RS00485	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
THIAE_RS00490	COG0676	glucose-6-phosphate 1-epimerase activity
THIAE_RS00505	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
THIAE_RS00510	COG3100	YcgL domain-containing protein
THIAE_RS00515	COG0702	epimerase
THIAE_RS00520	COG0617	tRNA 3'-terminal CCA addition
THIAE_RS00535	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
THIAE_RS00540	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
THIAE_RS00545	COG0126	phosphoglycerate kinase activity
THIAE_RS00555	COG0191	fructose-bisphosphate aldolase activity
THIAE_RS00560	COG1401	restriction endodeoxyribonuclease activity
THIAE_RS00580	COG2873	o-acetylhomoserine
THIAE_RS00585	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
THIAE_RS00590	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
THIAE_RS00600	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
THIAE_RS00605	COG0546	phosphoglycolate phosphatase activity
THIAE_RS00610	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
THIAE_RS00620	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THIAE_RS00625	COG0134	indole-3-glycerol-phosphate synthase activity
THIAE_RS00630	COG1765	OsmC-like protein
THIAE_RS00635	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
THIAE_RS00640	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THIAE_RS00645	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
THIAE_RS00665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THIAE_RS00675	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THIAE_RS00685	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
THIAE_RS00690	COG0081	regulation of translation
THIAE_RS00695	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
THIAE_RS00705	COG0085	RNA polymerase activity
THIAE_RS00710	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
THIAE_RS00715	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
THIAE_RS00720	COG0049	tRNA binding
THIAE_RS00725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THIAE_RS00730	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THIAE_RS00735	COG0051	transcription antitermination factor activity, RNA binding
THIAE_RS00740	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
THIAE_RS00745	COG0088	Forms part of the polypeptide exit tunnel
THIAE_RS00750	COG0089	rRNA binding
THIAE_RS00755	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
THIAE_RS00760	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
THIAE_RS00765	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
THIAE_RS00770	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
THIAE_RS00775	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
THIAE_RS00780	COG0255	Belongs to the universal ribosomal protein uL29 family
THIAE_RS00785	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
THIAE_RS00790	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
THIAE_RS00795	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
THIAE_RS00800	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
THIAE_RS00805	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
THIAE_RS00810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
THIAE_RS00815	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
THIAE_RS00820	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
THIAE_RS00825	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
THIAE_RS00830	COG1841	ribosomal large subunit assembly
THIAE_RS00835	COG0200	Binds to the 23S rRNA
THIAE_RS00840	COG0201	protein transport
THIAE_RS00845	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
THIAE_RS00850	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
THIAE_RS00855	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
THIAE_RS00860	COG0202	RNA polymerase activity
THIAE_RS00865	COG0203	ribosomal protein L17
THIAE_RS00870	COG0084	hydrolase, TatD family'
THIAE_RS00875	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
THIAE_RS00885	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
THIAE_RS00890	COG1116	anion transmembrane transporter activity
THIAE_RS00895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THIAE_RS00900	COG1116	anion transmembrane transporter activity
THIAE_RS00900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THIAE_RS00905	COG3604	Transcriptional regulator
THIAE_RS00910	COG0019	diaminopimelate decarboxylase activity
THIAE_RS00925	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THIAE_RS00955	COG0415	Belongs to the DNA photolyase family
THIAE_RS00960	COG3046	protein related to deoxyribodipyrimidine photolyase
THIAE_RS00970	COG2814	Major facilitator Superfamily
THIAE_RS00975	COG0629	single-stranded DNA binding
THIAE_RS00985	COG0142	geranyltranstransferase activity
THIAE_RS00990	COG0261	This protein binds to 23S rRNA in the presence of protein L20
THIAE_RS00995	COG0211	Belongs to the bacterial ribosomal protein bL27 family
THIAE_RS01000	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THIAE_RS01005	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
THIAE_RS01010	COG0477	Major facilitator Superfamily
THIAE_RS01020	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
THIAE_RS01025	COG4943	cyclic-guanylate-specific phosphodiesterase activity
THIAE_RS01030	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THIAE_RS01035	COG0459	protein refolding
THIAE_RS01040	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
THIAE_RS01045	COG0316	Belongs to the HesB IscA family
THIAE_RS01055	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
THIAE_RS01060	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
THIAE_RS01065	COG1366	Belongs to the anti-sigma-factor antagonist family
THIAE_RS01070	COG0789	Transcriptional regulator
THIAE_RS01075	COG0415	Belongs to the DNA photolyase family
THIAE_RS01090	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
THIAE_RS01105	COG0300	oxidoreductase activity
THIAE_RS01120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THIAE_RS01125	COG1121	(ABC) transporter
THIAE_RS01140	COG0719	Fe-S assembly protein
THIAE_RS01145	COG0396	ATPase activity
THIAE_RS01150	COG0719	Fe-S assembly protein
THIAE_RS01160	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THIAE_RS01165	COG1181	Belongs to the D-alanine--D-alanine ligase family
THIAE_RS01180	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
THIAE_RS01190	COG0653	protein targeting
THIAE_RS01195	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
THIAE_RS01200	COG0352	thiamine-phosphate diphosphorylase activity
THIAE_RS01205	COG0237	dephospho-CoA kinase activity
THIAE_RS01215	COG0367	asparagine synthase
THIAE_RS01220	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
THIAE_RS01235	COG0129	dihydroxy-acid dehydratase activity
THIAE_RS01245	COG3258	Cytochrome c
THIAE_RS01275	COG1210	Utp--glucose-1-phosphate uridylyltransferase
THIAE_RS01280	COG0166	Belongs to the GPI family
THIAE_RS01290	COG1183	phosphatidylcholine synthase activity
THIAE_RS01295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THIAE_RS01305	COG0456	acetyltransferase
THIAE_RS01325	COG1959	2 iron, 2 sulfur cluster binding
THIAE_RS01330	COG0316	Belongs to the HesB IscA family
THIAE_RS01335	COG0105	UTP biosynthetic process
THIAE_RS01340	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THIAE_RS01350	COG0124	histidyl-tRNA synthetase
THIAE_RS01360	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THIAE_RS01365	COG1160	GTP binding
THIAE_RS01370	COG0277	FAD linked oxidase domain protein
THIAE_RS01385	COG1162	GTPase activity
THIAE_RS01390	COG2154	pterin-4-alpha-carbinolamine dehydratase
THIAE_RS01395	COG0501	Belongs to the peptidase M48B family
THIAE_RS01400	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
THIAE_RS01405	COG0028	Belongs to the TPP enzyme family
THIAE_RS01415	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
THIAE_RS01420	COG0493	'glutamate synthase
THIAE_RS01425	COG0070	glutamate synthase
THIAE_RS01425	COG0069	glutamate synthase activity
THIAE_RS01425	COG0067	glutamate synthase
THIAE_RS01430	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
THIAE_RS01435	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
THIAE_RS01440	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THIAE_RS01450	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
THIAE_RS01455	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
THIAE_RS01460	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
THIAE_RS01465	COG0167	dihydroorotate dehydrogenase activity
THIAE_RS01470	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
THIAE_RS01500	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
THIAE_RS01500	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
THIAE_RS01505	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
THIAE_RS01515	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THIAE_RS01535	COG0552	protein localization to endoplasmic reticulum
THIAE_RS01540	COG0612	Peptidase, M16
THIAE_RS01545	COG0612	Peptidase, M16
THIAE_RS01550	COG0742	ribosomal rna small subunit methyltransferase
THIAE_RS01555	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
THIAE_RS01565	COG1666	GTP binding
THIAE_RS01570	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THIAE_RS01595	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
THIAE_RS01600	COG0248	Ppx GppA phosphatase
THIAE_RS01610	COG0628	permease
THIAE_RS01615	COG0756	dUTP diphosphatase activity
THIAE_RS01620	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
THIAE_RS01635	COG1090	epimerase
THIAE_RS01650	COG0509	glycine decarboxylation via glycine cleavage system
THIAE_RS01660	COG1012	belongs to the aldehyde dehydrogenase family
THIAE_RS01665	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
THIAE_RS01670	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
THIAE_RS01675	COG2026	Addiction module toxin, RelE StbE family
THIAE_RS01680	COG3077	Addiction module antitoxin, RelB DinJ family
THIAE_RS01690	COG0732	type I restriction modification DNA specificity domain
THIAE_RS01700	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
THIAE_RS01705	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
THIAE_RS01720	COG0840	transmembrane signaling receptor activity
THIAE_RS01730	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
THIAE_RS01735	COG0540	Belongs to the ATCase OTCase family
THIAE_RS01740	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
THIAE_RS01745	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
THIAE_RS01750	COG1678	Uncharacterized ACR, COG1678
THIAE_RS01755	COG1477	protein flavinylation
THIAE_RS01765	COG2308	Evidence 4 Homologs of previously reported genes of
THIAE_RS01780	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
THIAE_RS01780	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THIAE_RS01790	COG0227	Belongs to the bacterial ribosomal protein bL28 family
THIAE_RS01795	COG2003	Belongs to the UPF0758 family
THIAE_RS01810	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
THIAE_RS01810	COG2813	Specifically methylates the guanine in position
THIAE_RS01815	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
THIAE_RS01820	COG0762	integral membrane protein
THIAE_RS01830	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
THIAE_RS01835	COG1999	signal sequence binding
THIAE_RS01840	COG0840	transmembrane signaling receptor activity
THIAE_RS01845	COG1469	GTP cyclohydrolase I activity
THIAE_RS01850	COG0523	cobalamin synthesis protein
THIAE_RS01855	COG0579	oxidoreductase
THIAE_RS01865	COG0667	Aldo Keto reductase
THIAE_RS01875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THIAE_RS01890	COG0308	aminopeptidase N
THIAE_RS01925	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THIAE_RS01935	COG4771	TonB-dependent receptor
THIAE_RS01940	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
THIAE_RS01950	COG2226	methyltransferase
THIAE_RS01970	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
THIAE_RS01975	COG0709	Synthesizes selenophosphate from selenide and ATP
THIAE_RS01980	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
THIAE_RS01985	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
THIAE_RS01995	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
THIAE_RS02000	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
THIAE_RS02005	COG0500	methyltransferase
THIAE_RS02015	COG0542	response to heat
THIAE_RS02020	COG3706	GGDEF domain
THIAE_RS02030	COG2982	Protein involved in outer membrane biogenesis
THIAE_RS02035	COG2267	carboxylic ester hydrolase activity
THIAE_RS02060	COG0277	FAD linked oxidase domain protein
THIAE_RS02065	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THIAE_RS02070	COG0351	phosphomethylpyrimidine kinase
THIAE_RS02075	COG0352	thiamine-phosphate diphosphorylase activity
THIAE_RS02085	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
THIAE_RS02120	COG0840	transmembrane signaling receptor activity
THIAE_RS02120	COG0840	transmembrane signaling receptor activity
THIAE_RS02135	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THIAE_RS02145	COG0668	transmembrane transport
THIAE_RS02155	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THIAE_RS02160	COG1702	phosphate starvation-inducible protein PhoH
THIAE_RS02165	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
THIAE_RS02170	COG4535	Mg2 and Co2 transporter CorC
THIAE_RS02175	COG0815	Transfers the fatty acyl group on membrane lipoproteins
THIAE_RS02180	COG0174	glutamine synthetase
THIAE_RS02185	COG0573	inorganic phosphate transmembrane transporter activity
THIAE_RS02190	COG0581	inorganic phosphate transmembrane transporter activity
THIAE_RS02195	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THIAE_RS02205	COG0745	RESPONSE REGULATOR receiver
THIAE_RS02230	COG0840	transmembrane signaling receptor activity
THIAE_RS02260	COG0633	Ferredoxin
THIAE_RS02265	COG0271	Belongs to the BolA IbaG family
THIAE_RS02280	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
THIAE_RS02285	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
THIAE_RS02295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THIAE_RS02295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THIAE_RS02300	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
THIAE_RS02305	COG3178	'Phosphotransferase
THIAE_RS02320	COG3022	response to hydroperoxide
THIAE_RS02350	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
THIAE_RS02355	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
THIAE_RS02360	COG0321	lipoyl(octanoyl) transferase activity
THIAE_RS02365	COG2921	Belongs to the UPF0250 family
THIAE_RS02375	COG1686	Belongs to the peptidase S11 family
THIAE_RS02380	COG0772	Belongs to the SEDS family
THIAE_RS02385	COG0768	penicillin binding
THIAE_RS02390	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
THIAE_RS02395	COG1792	Involved in formation and maintenance of cell shape
THIAE_RS02400	COG1077	Cell shape determining protein MreB Mrl
THIAE_RS02405	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THIAE_RS02410	COG0154	amidase activity
THIAE_RS02415	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THIAE_RS02420	COG0501	Belongs to the peptidase M48B family
THIAE_RS02425	COG2166	iron-sulfur cluster assembly
THIAE_RS02430	COG0617	tRNA 3'-terminal CCA addition
THIAE_RS02435	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
THIAE_RS02440	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
THIAE_RS02445	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
THIAE_RS02450	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
THIAE_RS02455	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
THIAE_RS02460	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
THIAE_RS02465	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
THIAE_RS02470	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
THIAE_RS02475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THIAE_RS02480	COG0557	exoribonuclease II activity
THIAE_RS02485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THIAE_RS02490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THIAE_RS02495	COG0306	phosphate transporter
THIAE_RS02500	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
THIAE_RS02525	COG0713	ATP synthesis coupled electron transport
THIAE_RS02530	COG0651	ATP synthesis coupled electron transport
THIAE_RS02535	COG0651	ATP synthesis coupled electron transport
THIAE_RS02545	COG4804	nuclease activity
THIAE_RS02555	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
THIAE_RS02595	COG2133	pyrroloquinoline quinone binding
THIAE_RS02600	COG3001	Fructosamine kinase
THIAE_RS02610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THIAE_RS02610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THIAE_RS02625	COG0714	Associated with various cellular activities
THIAE_RS02655	COG1007	ATP synthesis coupled electron transport
THIAE_RS02660	COG0651	ATP synthesis coupled electron transport
THIAE_RS02675	COG0330	HflC and HflK could
THIAE_RS02700	COG0784	Response regulator, receiver
THIAE_RS02700	COG2198	Histidine kinase
THIAE_RS02700	COG2205	protein histidine kinase activity
THIAE_RS02700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THIAE_RS02705	COG0840	transmembrane signaling receptor activity
THIAE_RS02730	COG3437	response regulator, receiver
THIAE_RS02730	COG2205	protein histidine kinase activity
THIAE_RS02730	COG4999	Histidine kinase
THIAE_RS02730	COG3850	Histidine kinase
THIAE_RS02750	COG0446	pyridine nucleotide-disulphide oxidoreductase
THIAE_RS02775	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
THIAE_RS02780	COG0583	DNA-binding transcription factor activity
THIAE_RS02795	COG3328	transposase activity
THIAE_RS02810	COG1595	DNA-templated transcription, initiation
THIAE_RS02815	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THIAE_RS02820	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THIAE_RS02840	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
THIAE_RS02845	COG0739	heme binding
THIAE_RS02855	COG0752	glycyl-tRNA synthetase alpha subunit
THIAE_RS02860	COG0751	glycine-tRNA ligase activity
THIAE_RS02890	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
THIAE_RS02910	COG0028	Belongs to the TPP enzyme family
THIAE_RS02920	COG0196	riboflavin kinase activity
THIAE_RS02925	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
THIAE_RS02930	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
THIAE_RS02935	COG2203	Gaf domain
THIAE_RS02935	COG2199	diguanylate cyclase activity
THIAE_RS02950	COG2951	lytic endotransglycosylase activity
THIAE_RS02955	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
THIAE_RS02955	COG0116	Belongs to the methyltransferase superfamily
THIAE_RS02975	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THIAE_RS03000	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
THIAE_RS03025	COG0006	proline dipeptidase activity
THIAE_RS03030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
THIAE_RS03035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
THIAE_RS03040	COG0583	DNA-binding transcription factor activity
THIAE_RS03055	COG1530	ribonuclease E activity
THIAE_RS03065	COG0546	phosphoglycolate phosphatase activity
THIAE_RS03070	COG0424	maF-like protein
THIAE_RS03075	COG1399	metal-binding, possibly nucleic acid-binding protein
THIAE_RS03080	COG0333	Belongs to the bacterial ribosomal protein bL32 family
THIAE_RS03085	COG0416	fatty acid biosynthetic process
THIAE_RS03090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THIAE_RS03095	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
THIAE_RS03105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THIAE_RS03110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THIAE_RS03115	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
THIAE_RS03125	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
THIAE_RS03130	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
THIAE_RS03140	COG0084	hydrolase, TatD family'
THIAE_RS03145	COG1132	(ABC) transporter
THIAE_RS03170	COG1047	Peptidyl-prolyl cis-trans
THIAE_RS03180	COG0045	succinate-CoA ligase (ADP-forming) activity
THIAE_RS03185	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
THIAE_RS03190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THIAE_RS03190	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THIAE_RS03205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THIAE_RS03210	COG1472	Belongs to the glycosyl hydrolase 3 family
THIAE_RS03220	COG0733	neurotransmitter:sodium symporter activity
THIAE_RS03235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
THIAE_RS03240	COG1393	Belongs to the ArsC family
THIAE_RS03260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THIAE_RS03275	COG0826	peptidase U32
THIAE_RS03280	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
THIAE_RS03290	COG2915	High frequency lysogenization protein hflD homolog
THIAE_RS03295	COG0482	sulfurtransferase activity
THIAE_RS03310	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
THIAE_RS03315	COG0542	response to heat
THIAE_RS03325	COG2515	1-aminocyclopropane-1-carboxylate deaminase
THIAE_RS03330	COG1067	ATP-dependent peptidase activity
THIAE_RS03340	COG0658	competence protein
THIAE_RS03340	COG2333	competence protein COMEC
THIAE_RS03360	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
THIAE_RS03370	COG1663	tetraacyldisaccharide 4'-kinase activity
THIAE_RS03375	COG2835	tetraacyldisaccharide 4'-kinase activity
THIAE_RS03380	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
THIAE_RS03390	COG3150	esterase
THIAE_RS03395	COG0850	regulation of cytokinetic process
THIAE_RS03400	COG2894	cell division
THIAE_RS03405	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
THIAE_RS03415	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
THIAE_RS03430	COG1136	(ABC) transporter
THIAE_RS03435	COG0488	(ABC) transporter
THIAE_RS03455	COG2201	protein-glutamate methylesterase activity
THIAE_RS03465	COG0513	Belongs to the DEAD box helicase family
THIAE_RS03485	COG1999	signal sequence binding
THIAE_RS03495	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
THIAE_RS03500	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
THIAE_RS03505	COG4181	ATPase activity
THIAE_RS03515	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
THIAE_RS03525	COG2914	Belongs to the UPF0125 (RnfH) family
THIAE_RS03530	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THIAE_RS03535	COG0735	belongs to the Fur family
THIAE_RS03540	COG0497	DNA recombination
THIAE_RS03545	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
THIAE_RS03550	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THIAE_RS03555	COG0443	Heat shock 70 kDa protein
THIAE_RS03560	COG0484	heat shock protein binding
THIAE_RS03565	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
THIAE_RS03570	COG0505	Belongs to the CarA family
THIAE_RS03580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
THIAE_RS03590	COG2833	Protein of unknown function (DUF455)
THIAE_RS03595	COG1940	carbohydrate kinase activity
THIAE_RS03600	COG0617	tRNA 3'-terminal CCA addition
THIAE_RS03600	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THIAE_RS03600	COG0517	IMP dehydrogenase activity
THIAE_RS03605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THIAE_RS03615	COG2197	response regulator
THIAE_RS03625	COG2203	Gaf domain
THIAE_RS03625	COG2199	diguanylate cyclase activity
THIAE_RS03630	COG0488	(ABC) transporter
THIAE_RS03635	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
THIAE_RS03640	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THIAE_RS03645	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THIAE_RS03645	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THIAE_RS03660	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
THIAE_RS03665	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THIAE_RS03670	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
THIAE_RS03675	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
THIAE_RS03690	COG0720	synthase
THIAE_RS03695	COG0142	geranyltranstransferase activity
THIAE_RS03700	COG0300	oxidoreductase activity
THIAE_RS03710	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
THIAE_RS03715	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
THIAE_RS03725	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
THIAE_RS03730	COG0632	four-way junction helicase activity
THIAE_RS03735	COG2255	four-way junction helicase activity
THIAE_RS03745	COG0848	biopolymer transport protein
THIAE_RS03755	COG0823	Involved in the tonB-independent uptake of proteins
THIAE_RS03775	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
THIAE_RS03795	COG0354	folic acid binding
THIAE_RS03800	COG0835	chemotaxis
THIAE_RS03805	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
THIAE_RS03815	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
THIAE_RS03820	COG1815	bacterial-type flagellum-dependent cell motility
THIAE_RS03825	COG1558	bacterial-type flagellum-dependent cell motility
THIAE_RS03835	COG1749	Flagellar hook protein flgE
THIAE_RS03840	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
THIAE_RS03845	COG0343	queuine tRNA-ribosyltransferase activity
THIAE_RS03850	COG1862	Preprotein translocase
THIAE_RS03855	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THIAE_RS03860	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THIAE_RS03865	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
THIAE_RS03875	COG0492	ferredoxin-NADP+ reductase activity
THIAE_RS03885	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
THIAE_RS03890	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
THIAE_RS03895	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THIAE_RS03900	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
THIAE_RS03910	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
THIAE_RS03935	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
THIAE_RS03940	COG0024	Methionine aminopeptidase
THIAE_RS03945	COG0052	Belongs to the universal ribosomal protein uS2 family
THIAE_RS03950	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
THIAE_RS03955	COG0528	UMP kinase activity
THIAE_RS03960	COG0233	cytoplasmic translational termination
THIAE_RS03965	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
THIAE_RS03970	COG0575	Belongs to the CDS family
THIAE_RS03980	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THIAE_RS03990	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THIAE_RS03995	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THIAE_RS04000	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THIAE_RS04005	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THIAE_RS04010	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
THIAE_RS04015	COG0835	chemotaxis
THIAE_RS04015	COG0784	Response regulator, receiver
THIAE_RS04020	COG0257	Belongs to the bacterial ribosomal protein bL36 family
THIAE_RS04025	COG1199	ATP-dependent helicase activity
THIAE_RS04030	COG1214	PFAM Peptidase M22, glycoprotease
THIAE_RS04035	COG0589	response to stress
THIAE_RS04050	COG1555	photosystem II stabilization
THIAE_RS04060	COG1132	(ABC) transporter
THIAE_RS04075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THIAE_RS04105	COG0859	PFAM glycosyl transferase family 9
THIAE_RS04180	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
THIAE_RS04305	COG1215	transferase activity, transferring glycosyl groups
THIAE_RS04310	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
THIAE_RS04350	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
THIAE_RS04380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THIAE_RS04385	COG0481	GTPase activity
THIAE_RS04390	COG0681	Belongs to the peptidase S26 family
THIAE_RS04395	COG0571	ribonuclease III activity
THIAE_RS04410	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
THIAE_RS04415	COG0736	holo-[acyl-carrier-protein] synthase activity
THIAE_RS04420	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
THIAE_RS04450	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
THIAE_RS04455	COG0587	DNA-directed DNA polymerase activity
THIAE_RS04460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THIAE_RS04470	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
THIAE_RS04485	COG0779	Required for maturation of 30S ribosomal subunits
THIAE_RS04490	COG2251	uridine kinase activity
THIAE_RS04490	COG0195	Participates in both transcription termination and antitermination
THIAE_RS04495	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
THIAE_RS04500	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
THIAE_RS04505	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
THIAE_RS04520	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
THIAE_RS04525	COG1185	polyribonucleotide nucleotidyltransferase activity
THIAE_RS04545	COG0601	transmembrane transport
THIAE_RS04550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THIAE_RS04595	COG3530	Putative quorum-sensing-regulated virulence factor
THIAE_RS04635	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
THIAE_RS04645	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
THIAE_RS04660	COG0745	RESPONSE REGULATOR receiver
THIAE_RS04665	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
THIAE_RS04670	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THIAE_RS04675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THIAE_RS04695	COG0659	secondary active sulfate transmembrane transporter activity
THIAE_RS04710	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
THIAE_RS04715	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
THIAE_RS04720	COG2183	response to ionizing radiation
THIAE_RS04740	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
THIAE_RS04755	COG1028	Short-chain dehydrogenase reductase Sdr
THIAE_RS04765	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THIAE_RS04775	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
THIAE_RS04785	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THIAE_RS04790	COG0287	Prephenate dehydrogenase
THIAE_RS04795	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
THIAE_RS04800	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
THIAE_RS04810	COG0776	regulation of translation
THIAE_RS04820	COG0284	orotidine-5'-phosphate decarboxylase activity
THIAE_RS04825	COG0360	Binds together with S18 to 16S ribosomal RNA
THIAE_RS04830	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
THIAE_RS04840	COG0359	binds to the 23S rRNA
THIAE_RS04845	COG0305	Participates in initiation and elongation during chromosome replication
THIAE_RS04850	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
THIAE_RS04885	COG3437	response regulator, receiver
THIAE_RS04910	COG1570	exodeoxyribonuclease VII activity
THIAE_RS04910	COG1570	exodeoxyribonuclease VII activity
THIAE_RS04915	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
THIAE_RS04930	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
THIAE_RS04935	COG2199	diguanylate cyclase activity
THIAE_RS04935	COG2200	EAL domain
THIAE_RS04945	COG0303	'Molybdopterin
THIAE_RS04955	COG1648	precorrin-2 dehydrogenase activity
THIAE_RS04955	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
THIAE_RS04960	COG0243	molybdopterin cofactor binding
THIAE_RS04970	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THIAE_RS04975	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THIAE_RS04980	COG1116	anion transmembrane transporter activity
THIAE_RS04985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THIAE_RS04990	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THIAE_RS04995	COG3707	response regulator
THIAE_RS05000	COG0419	ATPase involved in DNA repair
THIAE_RS05005	COG0420	3'-5' exonuclease activity
THIAE_RS05025	COG3012	SEC-C Motif Domain Protein
THIAE_RS05030	COG2337	Toxic component of a toxin-antitoxin (TA) module
THIAE_RS05065	COG0322	excinuclease ABC activity
THIAE_RS05070	COG0616	signal peptide processing
THIAE_RS05070	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
THIAE_RS05075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THIAE_RS05080	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THIAE_RS05090	COG0363	glucosamine-6-phosphate deaminase activity
THIAE_RS05095	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
THIAE_RS05100	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
THIAE_RS05135	COG2954	triphosphatase activity
THIAE_RS05160	COG1187	pseudouridine synthase activity
THIAE_RS05165	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
THIAE_RS05170	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
THIAE_RS05175	COG1994	Peptidase M50
THIAE_RS05180	COG0009	L-threonylcarbamoyladenylate synthase
THIAE_RS05185	COG0613	PHP domain protein
THIAE_RS05190	COG2917	probably involved in intracellular septation
THIAE_RS05195	COG2350	Protein conserved in bacteria
THIAE_RS05200	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
THIAE_RS05215	COG3028	Belongs to the UPF0307 family
THIAE_RS05220	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THIAE_RS05230	COG1196	nuclear chromosome segregation
THIAE_RS05235	COG1070	Carbohydrate kinase
THIAE_RS05245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THIAE_RS05260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THIAE_RS05270	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
THIAE_RS05270	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
THIAE_RS05275	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
THIAE_RS05290	COG0436	Aminotransferase
THIAE_RS05300	COG4942	peptidase
THIAE_RS05305	COG1238	metal cluster binding
THIAE_RS05310	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THIAE_RS05325	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
THIAE_RS05330	COG0148	phosphopyruvate hydratase activity
THIAE_RS05335	COG2877	3-deoxy-8-phosphooctulonate synthase activity
THIAE_RS05340	COG0504	CTP synthase activity
THIAE_RS05350	COG0825	malonyl-CoA metabolic process
THIAE_RS05360	COG1944	ATP diphosphatase activity
THIAE_RS05375	COG0564	pseudouridine synthase activity
THIAE_RS05385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THIAE_RS05390	COG0508	dehydrogenase complex catalyzes the overall conversion of
THIAE_RS05395	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
THIAE_RS05400	COG1051	belongs to the nudix hydrolase family
THIAE_RS05420	COG3023	N-Acetylmuramoyl-L-alanine amidase
THIAE_RS05430	COG1496	oxidoreductase activity
THIAE_RS05435	COG0564	pseudouridine synthase activity
THIAE_RS05450	COG0328	RNA-DNA hybrid ribonuclease activity
THIAE_RS05460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THIAE_RS05465	COG0741	lytic transglycosylase activity
THIAE_RS05465	COG1388	LysM domain
THIAE_RS05470	COG0741	lytic transglycosylase activity
THIAE_RS05475	COG0215	cysteine-tRNA ligase activity
THIAE_RS05490	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
THIAE_RS05495	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THIAE_RS05500	COG1301	dicarboxylic acid transport
THIAE_RS05510	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
THIAE_RS05515	COG0137	argininosuccinate synthase activity
THIAE_RS05520	COG0688	phosphatidylethanolamine metabolic process
THIAE_RS05530	COG2204	response regulator
THIAE_RS05545	COG0803	Belongs to the bacterial solute-binding protein 9 family
THIAE_RS05550	COG1121	(ABC) transporter
THIAE_RS05555	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THIAE_RS05555	COG1321	iron dependent repressor
THIAE_RS05570	COG1049	propionate catabolic process, 2-methylcitrate cycle
THIAE_RS05580	COG2850	peptidyl-arginine hydroxylation
THIAE_RS05620	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THIAE_RS05625	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
THIAE_RS05630	COG0740	serine-type endopeptidase activity
THIAE_RS05635	COG0544	peptidyl-prolyl cis-trans isomerase activity
THIAE_RS05640	COG2363	Small membrane protein
THIAE_RS05755	COG1061	Type III restriction enzyme res subunit
THIAE_RS05805	COG0488	(ABC) transporter
THIAE_RS05810	COG1981	membrane
THIAE_RS05815	COG1047	Peptidyl-prolyl cis-trans
THIAE_RS05825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THIAE_RS05830	COG2894	cell division
THIAE_RS05860	COG3328	transposase activity
THIAE_RS05880	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
THIAE_RS05920	COG2003	Belongs to the UPF0758 family
THIAE_RS06045	COG3328	transposase activity
THIAE_RS06065	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
THIAE_RS06095	COG3621	Patatin-like phospholipase
THIAE_RS06145	COG0582	viral genome integration into host DNA
THIAE_RS06160	COG1007	ATP synthesis coupled electron transport
THIAE_RS06175	COG0713	ATP synthesis coupled electron transport
THIAE_RS06185	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THIAE_RS06190	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
THIAE_RS06195	COG1034	ATP synthesis coupled electron transport
THIAE_RS06205	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
THIAE_RS06210	COG0649	NAD binding
THIAE_RS06215	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THIAE_RS06220	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THIAE_RS06225	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THIAE_RS06240	COG0149	triose-phosphate isomerase activity
THIAE_RS06245	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THIAE_RS06250	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
THIAE_RS06255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THIAE_RS06260	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
THIAE_RS06265	COG1534	Rna-binding protein
THIAE_RS06285	COG0285	dihydrofolate synthase activity
THIAE_RS06290	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
THIAE_RS06295	COG0159	tryptophan synthase activity
THIAE_RS06300	COG0133	tryptophan synthase activity
THIAE_RS06305	COG0135	phosphoribosylanthranilate isomerase activity
THIAE_RS06310	COG0101	tRNA pseudouridine synthase activity
THIAE_RS06315	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
THIAE_RS06325	COG0739	heme binding
THIAE_RS06330	COG0473	3-isopropylmalate dehydrogenase activity
THIAE_RS06335	COG0066	3-isopropylmalate dehydratase activity
THIAE_RS06340	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THIAE_RS06345	COG0602	queuosine metabolic process
THIAE_RS06365	COG2205	protein histidine kinase activity
THIAE_RS06365	COG0784	Response regulator, receiver
THIAE_RS06370	COG1917	Cupin 2, conserved barrel domain protein
THIAE_RS06375	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
THIAE_RS06380	COG0456	acetyltransferase
THIAE_RS06385	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
THIAE_RS06390	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
THIAE_RS06395	COG2890	protein-(glutamine-N5) methyltransferase activity
THIAE_RS06400	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
THIAE_RS06435	COG0424	maF-like protein
THIAE_RS06440	COG0442	prolyl-tRNA aminoacylation
THIAE_RS06465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THIAE_RS06470	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THIAE_RS06480	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
THIAE_RS06485	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
THIAE_RS06495	COG0717	Belongs to the dCTP deaminase family
THIAE_RS06500	COG0489	protein tyrosine kinase activity
THIAE_RS06505	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THIAE_RS06505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THIAE_RS06510	COG4657	Part of a membrane complex involved in electron transport
THIAE_RS06515	COG2878	Part of a membrane complex involved in electron transport
THIAE_RS06530	COG4659	FMN binding
THIAE_RS06540	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THIAE_RS06555	COG4206	TonB-dependent receptor
THIAE_RS06570	COG0583	DNA-binding transcription factor activity
THIAE_RS06580	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THIAE_RS06585	COG4681	YaeQ
THIAE_RS06590	COG4628	conserved protein (DUF2132)
THIAE_RS06605	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
THIAE_RS06635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THIAE_RS06700	COG5002	protein histidine kinase activity
THIAE_RS06715	COG1643	Atp-dependent helicase
THIAE_RS06720	COG4115	mRNA cleavage
THIAE_RS06725	COG2161	toxin-antitoxin pair type II binding
THIAE_RS06735	COG1047	Peptidyl-prolyl cis-trans
THIAE_RS06745	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
THIAE_RS06770	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
THIAE_RS06775	COG1074	ATP-dependent DNA helicase activity
THIAE_RS06780	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
THIAE_RS06785	COG1671	Belongs to the UPF0178 family
THIAE_RS06790	COG3012	SEC-C Motif Domain Protein
THIAE_RS06820	COG3328	transposase activity
THIAE_RS06825	COG1487	ribonuclease activity
THIAE_RS06835	COG0232	Belongs to the dGTPase family. Type 2 subfamily
THIAE_RS06840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THIAE_RS06855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THIAE_RS06885	COG0668	transmembrane transport
THIAE_RS06900	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
THIAE_RS06905	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
THIAE_RS06910	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
THIAE_RS06915	COG0330	HflC and HflK could
THIAE_RS06920	COG0330	HflC and HflK could
THIAE_RS06925	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
THIAE_RS06930	COG1923	regulation of RNA biosynthetic process
THIAE_RS06935	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
THIAE_RS06940	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
THIAE_RS06950	COG0802	atpase or kinase
THIAE_RS06955	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
THIAE_RS06965	COG0643	Histidine kinase
THIAE_RS06965	COG2198	Histidine kinase
THIAE_RS06965	COG0784	Response regulator, receiver
THIAE_RS06995	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THIAE_RS07000	COG3328	transposase activity
THIAE_RS07050	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
THIAE_RS07080	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THIAE_RS07090	COG1677	Flagellar hook-basal body complex protein FliE
THIAE_RS07115	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
THIAE_RS07130	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THIAE_RS07140	COG1028	Short-chain dehydrogenase reductase Sdr
THIAE_RS07145	COG1083	cytidylyl-transferase
THIAE_RS07170	COG1011	Hydrolase
THIAE_RS07190	COG4804	nuclease activity
THIAE_RS07195	COG2089	acid synthase
THIAE_RS07205	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THIAE_RS07210	COG1088	dTDP-glucose 4,6-dehydratase activity
THIAE_RS07215	COG0741	lytic transglycosylase activity
THIAE_RS07220	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THIAE_RS07235	COG1706	bacterial-type flagellum-dependent cell motility
THIAE_RS07240	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
THIAE_RS07265	COG0527	aspartate kinase activity
THIAE_RS07270	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
THIAE_RS07275	COG2137	regulation of response to DNA damage stimulus
THIAE_RS07280	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
THIAE_RS07285	COG1546	Belongs to the CinA family
THIAE_RS07310	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THIAE_RS07315	COG3118	belongs to the thioredoxin family
THIAE_RS07330	COG0189	ligase activity
THIAE_RS07345	COG0335	large ribosomal subunit rRNA binding
THIAE_RS07350	COG0336	Belongs to the RNA methyltransferase TrmD family
THIAE_RS07355	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
THIAE_RS07360	COG0228	four-way junction DNA binding
THIAE_RS07365	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THIAE_RS07375	COG4536	flavin adenine dinucleotide binding
THIAE_RS07380	COG0483	inositol monophosphate 1-phosphatase activity
THIAE_RS07390	COG2857	Cytochrome c1
THIAE_RS07395	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
THIAE_RS07400	COG0723	plastoquinol--plastocyanin reductase activity
THIAE_RS07405	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
THIAE_RS07410	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THIAE_RS07415	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
THIAE_RS07420	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
THIAE_RS07425	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THIAE_RS07435	COG0842	Transport permease protein
THIAE_RS07440	COG1131	(ABC) transporter
THIAE_RS07455	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
THIAE_RS07460	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
THIAE_RS07465	COG1127	ABC transporter
THIAE_RS07480	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
THIAE_RS07495	COG1137	ATPase activity
THIAE_RS07505	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THIAE_RS07510	COG0564	pseudouridine synthase activity
THIAE_RS07530	COG0326	Molecular chaperone. Has ATPase activity
THIAE_RS07540	COG2198	Histidine kinase
THIAE_RS07540	COG0643	Histidine kinase
THIAE_RS07545	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
THIAE_RS07555	COG0519	Catalyzes the synthesis of GMP from XMP
THIAE_RS07555	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THIAE_RS07580	COG0560	Phosphoserine phosphatase
THIAE_RS07590	COG0811	peptide transport
THIAE_RS07595	COG0848	biopolymer transport protein
THIAE_RS07600	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
THIAE_RS07615	COG3123	guanosine phosphorylase activity
THIAE_RS07625	COG2814	Major facilitator Superfamily
THIAE_RS07630	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
THIAE_RS07640	COG2890	protein-(glutamine-N5) methyltransferase activity
THIAE_RS07645	COG0521	Mo-molybdopterin cofactor biosynthetic process
THIAE_RS07650	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THIAE_RS07660	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
THIAE_RS07665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THIAE_RS07670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THIAE_RS07675	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
THIAE_RS07685	COG0835	chemotaxis
THIAE_RS07685	COG0784	Response regulator, receiver
THIAE_RS07710	COG1218	3'(2'),5'-bisphosphate nucleotidase
THIAE_RS07715	COG0494	nUDIX hydrolase
THIAE_RS07720	COG1011	Hydrolase
THIAE_RS07725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THIAE_RS07730	COG0488	(ABC) transporter
THIAE_RS07750	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
THIAE_RS07760	COG3852	Histidine kinase
THIAE_RS07765	COG2204	response regulator
THIAE_RS07770	COG0798	PFAM Bile acid sodium symporter
THIAE_RS07775	COG3550	peptidyl-serine autophosphorylation
THIAE_RS07780	COG1396	sequence-specific DNA binding
THIAE_RS07800	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
THIAE_RS07845	COG0778	Nitroreductase
THIAE_RS07850	COG5002	protein histidine kinase activity
THIAE_RS07865	COG0745	RESPONSE REGULATOR receiver
THIAE_RS07870	COG2132	Multicopper oxidase
THIAE_RS07875	COG3667	copper resistance
THIAE_RS07890	COG3706	GGDEF domain
THIAE_RS07890	COG5001	Diguanylate cyclase
THIAE_RS07890	COG2203	Gaf domain
THIAE_RS07890	COG4251	negative regulation of phosphorylation
THIAE_RS07900	COG5001	Diguanylate cyclase
THIAE_RS07910	COG0500	methyltransferase
THIAE_RS07920	COG3030	protein affecting phage T7 exclusion by the F plasmid
THIAE_RS07925	COG4232	protein-disulfide reductase activity
THIAE_RS07930	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
THIAE_RS07940	COG0439	Biotin carboxylase
THIAE_RS07945	COG2264	protein methyltransferase activity
THIAE_RS07955	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
THIAE_RS07960	COG0138	bifunctional purine biosynthesis protein purh
THIAE_RS07965	COG0151	Belongs to the GarS family
THIAE_RS07970	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
THIAE_RS07975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THIAE_RS07985	COG3720	iron ion transport
THIAE_RS08000	COG4771	TonB-dependent receptor
THIAE_RS08105	COG1629	transport
THIAE_RS08105	COG4774	siderophore transport
THIAE_RS08135	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THIAE_RS08140	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
THIAE_RS08145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
THIAE_RS08150	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
THIAE_RS08160	COG0058	SHG alpha-glucan phosphorylase activity
THIAE_RS08165	COG0297	glycogen (starch) synthase activity
THIAE_RS08170	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
THIAE_RS08185	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
THIAE_RS08190	COG0837	glucose binding
THIAE_RS08195	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
THIAE_RS08200	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
THIAE_RS08200	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
THIAE_RS08210	COG0517	IMP dehydrogenase activity
THIAE_RS08210	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
THIAE_RS08215	COG1519	Transferase
THIAE_RS08235	COG1620	l-lactate permease
THIAE_RS08240	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
THIAE_RS08260	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THIAE_RS08265	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THIAE_RS08270	COG1385	rRNA (uridine-N3-)-methyltransferase activity
THIAE_RS08305	COG3852	Histidine kinase
THIAE_RS08315	COG1295	ribonuclease BN
THIAE_RS08320	COG0793	Belongs to the peptidase S41A family
THIAE_RS08325	COG0640	Transcriptional regulator
THIAE_RS08335	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THIAE_RS08340	COG0772	Belongs to the SEDS family
THIAE_RS08345	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
THIAE_RS08350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THIAE_RS08355	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
THIAE_RS08360	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THIAE_RS08375	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
THIAE_RS08380	COG0275	rRNA processing
THIAE_RS08385	COG2001	Belongs to the MraZ family
THIAE_RS08400	COG0792	nuclease activity
THIAE_RS08405	COG0783	Belongs to the Dps family
THIAE_RS08410	COG1346	cytolysis
THIAE_RS08445	COG0828	Belongs to the bacterial ribosomal protein bS21 family
THIAE_RS08450	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
THIAE_RS08455	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THIAE_RS08470	COG1968	undecaprenyl-diphosphatase activity
THIAE_RS08480	COG2239	Acts as a magnesium transporter
THIAE_RS08490	COG2239	Acts as a magnesium transporter
THIAE_RS08505	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
THIAE_RS08515	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
THIAE_RS08545	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
THIAE_RS08560	COG2210	Belongs to the sulfur carrier protein TusA family
THIAE_RS08605	COG0012	GTP binding
THIAE_RS08610	COG0193	aminoacyl-tRNA hydrolase activity
THIAE_RS08615	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
THIAE_RS08620	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
THIAE_RS08630	COG0268	Binds directly to 16S ribosomal RNA
THIAE_RS08635	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
THIAE_RS08640	COG0799	negative regulation of ribosome biogenesis
THIAE_RS08645	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
THIAE_RS08660	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
THIAE_RS08685	COG0495	leucyl-tRNA aminoacylation
THIAE_RS08720	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
THIAE_RS08720	COG2755	lipolytic protein G-D-S-L family
THIAE_RS08745	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
THIAE_RS08760	COG0004	ammonium transporteR
THIAE_RS08770	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THIAE_RS08780	COG0525	valine-tRNA ligase activity
THIAE_RS08795	COG4974	Belongs to the 'phage' integrase family
THIAE_RS08815	COG2945	thiolester hydrolase activity
THIAE_RS08820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THIAE_RS08845	COG1304	FMN binding
THIAE_RS08850	COG3425	synthase
THIAE_RS08870	COG2969	positive regulation of protein catabolic process
THIAE_RS08875	COG0625	glutathione transferase activity
THIAE_RS08900	COG0776	regulation of translation
THIAE_RS08905	COG0072	phenylalanine-tRNA ligase activity
THIAE_RS08905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THIAE_RS08910	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
THIAE_RS08915	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
THIAE_RS08920	COG0291	Belongs to the bacterial ribosomal protein bL35 family
THIAE_RS08925	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
THIAE_RS08930	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THIAE_RS08935	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THIAE_RS08945	COG0446	pyridine nucleotide-disulphide oxidoreductase
THIAE_RS08955	COG0795	lipopolysaccharide-transporting ATPase activity
THIAE_RS08965	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
THIAE_RS08995	COG0556	nucleotide-excision repair
THIAE_RS09000	COG0436	Aminotransferase
THIAE_RS09020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THIAE_RS09035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THIAE_RS09040	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
THIAE_RS09055	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THIAE_RS09085	COG2205	protein histidine kinase activity
THIAE_RS09090	COG0745	RESPONSE REGULATOR receiver
THIAE_RS09105	COG1309	transcriptional regulator
THIAE_RS09120	COG3328	transposase activity
THIAE_RS09130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THIAE_RS09135	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
THIAE_RS09160	COG2111	Na H antiporter
THIAE_RS09160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THIAE_RS09165	COG1006	Multisubunit Na H antiporter MnhC subunit
THIAE_RS09170	COG0651	ATP synthesis coupled electron transport
THIAE_RS09180	COG2212	antiporter activity
THIAE_RS09185	COG1320	monovalent cation:proton antiporter activity
THIAE_RS09195	COG0438	transferase activity, transferring glycosyl groups
THIAE_RS09195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THIAE_RS09205	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
THIAE_RS09220	COG1611	Belongs to the LOG family
THIAE_RS09225	COG0513	Belongs to the DEAD box helicase family
THIAE_RS09230	COG0840	transmembrane signaling receptor activity
THIAE_RS09235	COG0840	transmembrane signaling receptor activity
THIAE_RS09245	COG0585	pseudouridine synthase activity
THIAE_RS09260	COG1454	alcohol dehydrogenase
THIAE_RS09265	COG2337	Toxic component of a toxin-antitoxin (TA) module
THIAE_RS09275	COG0210	DNA helicase
THIAE_RS09295	COG2813	Specifically methylates the guanine in position
THIAE_RS09340	COG1309	transcriptional regulator
THIAE_RS09355	COG1538	Outer membrane efflux protein
THIAE_RS09365	COG0727	PFAM Uncharacterised protein family (UPF0153)
THIAE_RS09460	COG2189	Belongs to the N(4) N(6)-methyltransferase family
THIAE_RS09490	COG0606	chelatase, subunit chli
THIAE_RS09505	COG0018	arginyl-trna synthetase
THIAE_RS09525	COG0758	DNA mediated transformation
THIAE_RS09530	COG0242	peptide deformylase activity
THIAE_RS09535	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THIAE_RS09550	COG5000	phosphorelay sensor kinase activity
THIAE_RS09555	COG2204	response regulator
THIAE_RS09560	COG0569	domain protein
THIAE_RS09605	COG3278	Belongs to the heme-copper respiratory oxidase family
THIAE_RS09610	COG0131	Imidazoleglycerol-phosphate dehydratase
THIAE_RS09615	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
THIAE_RS09620	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
THIAE_RS09625	COG0107	imidazoleglycerol-phosphate synthase activity
THIAE_RS09630	COG0140	phosphoribosyl-ATP diphosphatase activity
THIAE_RS09635	COG0537	adenosine 5'-monophosphoramidase activity
THIAE_RS09645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THIAE_RS09675	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
THIAE_RS09680	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
THIAE_RS09690	COG0583	DNA-binding transcription factor activity
THIAE_RS09720	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
THIAE_RS09725	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
THIAE_RS09755	COG1850	ribulose-bisphosphate carboxylase activity
THIAE_RS09765	COG2226	methyltransferase
THIAE_RS09775	COG1278	Cold shock
THIAE_RS09785	COG0156	8-amino-7-oxononanoate synthase activity
THIAE_RS09790	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THIAE_RS09795	COG1040	competence protein
THIAE_RS09800	COG1929	Belongs to the glycerate kinase type-1 family
THIAE_RS09810	COG1215	transferase activity, transferring glycosyl groups
THIAE_RS09820	COG0210	DNA helicase
THIAE_RS09830	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
THIAE_RS09835	COG0254	rRNA binding
THIAE_RS09845	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
THIAE_RS09850	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
THIAE_RS09855	COG1194	a g-specific adenine glycosylase
THIAE_RS09860	COG0220	tRNA (guanine-N7-)-methyltransferase activity
THIAE_RS09870	COG3850	Histidine kinase
THIAE_RS09870	COG3437	response regulator, receiver
THIAE_RS09870	COG2205	protein histidine kinase activity
THIAE_RS09870	COG4999	Histidine kinase
THIAE_RS09880	COG3706	GGDEF domain
THIAE_RS09895	COG0037	tRNA processing
THIAE_RS09900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THIAE_RS09910	COG0745	RESPONSE REGULATOR receiver
THIAE_RS09915	COG3437	response regulator, receiver
THIAE_RS09940	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
THIAE_RS09950	COG2104	thiamine diphosphate biosynthetic process
THIAE_RS09955	COG2022	thiamine diphosphate biosynthetic process
THIAE_RS09960	COG1192	Involved in chromosome partitioning
THIAE_RS09970	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
THIAE_RS09975	COG2353	YceI-like domain
THIAE_RS09980	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
THIAE_RS09990	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
THIAE_RS09995	COG0355	proton-transporting ATP synthase activity, rotational mechanism
THIAE_RS10000	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
THIAE_RS10005	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
THIAE_RS10010	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
THIAE_RS10015	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THIAE_RS10020	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
THIAE_RS10025	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THIAE_RS10030	COG0356	it plays a direct role in the translocation of protons across the membrane
THIAE_RS10050	COG1192	Involved in chromosome partitioning
THIAE_RS10055	COG0357	Ribosomal RNA small subunit methyltransferase G
THIAE_RS10060	COG0445	tRNA wobble uridine modification
THIAE_RS10070	COG1643	Atp-dependent helicase
THIAE_RS10080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
THIAE_RS10085	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
THIAE_RS10085	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
THIAE_RS10095	COG1528	Iron-storage protein
THIAE_RS10100	COG4772	TonB-dependent receptor
THIAE_RS10130	COG0181	hydroxymethylbilane synthase activity
THIAE_RS10140	COG0165	Argininosuccinate lyase
THIAE_RS10160	COG2814	Major facilitator Superfamily
THIAE_RS10165	COG4999	Histidine kinase
THIAE_RS10165	COG3437	response regulator, receiver
THIAE_RS10165	COG3850	Histidine kinase
THIAE_RS10165	COG2205	protein histidine kinase activity
THIAE_RS10170	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
THIAE_RS10190	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
THIAE_RS10195	COG0339	signal peptide processing
THIAE_RS10215	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
THIAE_RS10230	COG0730	response to heat
THIAE_RS10235	COG0706	membrane insertase activity
THIAE_RS10240	COG0594	ribonuclease P activity
THIAE_RS10245	COG0230	Belongs to the bacterial ribosomal protein bL34 family
THIAE_RS10250	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THIAE_RS10255	COG0187	DNA topoisomerase II activity
THIAE_RS10275	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
THIAE_RS10280	COG0408	coproporphyrinogen oxidase activity
THIAE_RS10285	COG4783	chaperone-mediated protein folding
THIAE_RS10290	COG0218	Necessary for normal cell division and for the maintenance of normal septation
THIAE_RS10295	COG1333	cytochrome c biogenesis protein
THIAE_RS10300	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
THIAE_RS10315	COG0778	Nitroreductase
THIAE_RS10320	COG0583	DNA-binding transcription factor activity
THIAE_RS10330	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THIAE_RS10335	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
THIAE_RS10340	COG0009	L-threonylcarbamoyladenylate synthase
THIAE_RS10345	COG4208	sulfate ABC transporter
THIAE_RS10355	COG3842	ATPase activity
THIAE_RS10365	COG2304	oxidoreductase activity
THIAE_RS10385	COG0714	Associated with various cellular activities
THIAE_RS10390	COG0500	methyltransferase
THIAE_RS10395	COG2226	methyltransferase
THIAE_RS10400	COG0583	DNA-binding transcription factor activity
THIAE_RS10405	COG1741	Belongs to the pirin family
THIAE_RS10415	COG0741	lytic transglycosylase activity
THIAE_RS10440	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THIAE_RS10450	COG3437	response regulator, receiver
THIAE_RS10450	COG0784	Response regulator, receiver
THIAE_RS10455	COG3437	response regulator, receiver
THIAE_RS10455	COG0784	Response regulator, receiver
THIAE_RS10460	COG2197	response regulator
THIAE_RS10465	COG0840	transmembrane signaling receptor activity
THIAE_RS10485	COG0840	transmembrane signaling receptor activity
THIAE_RS10485	COG0840	transmembrane signaling receptor activity
THIAE_RS10490	COG2205	protein histidine kinase activity
THIAE_RS10490	COG0784	Response regulator, receiver
THIAE_RS10495	COG2205	protein histidine kinase activity
THIAE_RS10495	COG5002	protein histidine kinase activity
THIAE_RS10495	COG0784	Response regulator, receiver
THIAE_RS10545	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THIAE_RS10550	COG0746	molybdenum cofactor guanylyltransferase activity
THIAE_RS10560	COG2840	Smr protein MutS2
THIAE_RS10575	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
THIAE_RS10615	COG0784	Response regulator, receiver
THIAE_RS10615	COG2205	protein histidine kinase activity
THIAE_RS10625	COG3657	addiction module killer protein
THIAE_RS10635	COG2205	protein histidine kinase activity
THIAE_RS10635	COG0784	Response regulator, receiver
THIAE_RS10650	COG2169	Transcriptional regulator
THIAE_RS10650	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
THIAE_RS10660	COG0840	transmembrane signaling receptor activity
THIAE_RS10680	COG5002	protein histidine kinase activity
THIAE_RS10680	COG2205	protein histidine kinase activity
THIAE_RS10680	COG0784	Response regulator, receiver
THIAE_RS10690	COG1643	Atp-dependent helicase