locus-tag	class	description
TK90_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TK90_RS00010	COG0592	DNA-directed DNA polymerase activity
TK90_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TK90_RS00020	COG0187	DNA topoisomerase II activity
TK90_RS00030	COG0339	signal peptide processing
TK90_RS00040	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TK90_RS00050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TK90_RS00050	COG0543	2 iron, 2 sulfur cluster binding
TK90_RS00055	COG1587	Uroporphyrinogen-III synthase
TK90_RS00060	COG0181	hydroxymethylbilane synthase activity
TK90_RS00070	COG0745	RESPONSE REGULATOR receiver
TK90_RS00070	COG2972	Histidine kinase
TK90_RS00075	COG0165	Argininosuccinate lyase
TK90_RS00085	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
TK90_RS00095	COG0659	secondary active sulfate transmembrane transporter activity
TK90_RS00105	COG4772	TonB-dependent receptor
TK90_RS00115	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TK90_RS00125	COG1846	Transcriptional regulator
TK90_RS00140	COG1335	isochorismatase
TK90_RS00150	COG0540	Belongs to the ATCase OTCase family
TK90_RS00155	COG0367	asparagine synthase
TK90_RS00185	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TK90_RS00190	COG1333	cytochrome c biogenesis protein
TK90_RS00200	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TK90_RS00240	COG3852	Histidine kinase
TK90_RS00250	COG0167	dihydroorotate dehydrogenase activity
TK90_RS00255	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TK90_RS00265	COG0205	6-phosphofructokinase activity
TK90_RS00270	COG0563	adenylate kinase activity
TK90_RS00280	COG3302	dmso reductase anchor subunit
TK90_RS00285	COG0437	4 iron, 4 sulfur cluster binding
TK90_RS00290	COG0243	molybdopterin cofactor binding
TK90_RS00305	COG2046	Belongs to the sulfate adenylyltransferase family
TK90_RS00330	COG1047	Peptidyl-prolyl cis-trans
TK90_RS00340	COG0708	Exodeoxyribonuclease III
TK90_RS00345	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TK90_RS00375	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
TK90_RS00385	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TK90_RS00410	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
TK90_RS00415	COG0205	6-phosphofructokinase activity
TK90_RS00445	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TK90_RS00450	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TK90_RS00460	COG0268	Binds directly to 16S ribosomal RNA
TK90_RS00470	COG0210	DNA helicase
TK90_RS00475	COG0567	Dehydrogenase, E1 component
TK90_RS00480	COG0508	dehydrogenase complex catalyzes the overall conversion of
TK90_RS00495	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TK90_RS00505	COG2226	methyltransferase
TK90_RS00550	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TK90_RS00555	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TK90_RS00560	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TK90_RS00570	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TK90_RS00575	COG4106	trans-aconitate 2-methyltransferase activity
TK90_RS00595	COG0131	Imidazoleglycerol-phosphate dehydratase
TK90_RS00600	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TK90_RS00605	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TK90_RS00610	COG0107	imidazoleglycerol-phosphate synthase activity
TK90_RS00615	COG0140	phosphoribosyl-ATP diphosphatase activity
TK90_RS00620	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TK90_RS00625	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TK90_RS00630	COG0805	protein transport
TK90_RS00635	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TK90_RS00660	COG3706	GGDEF domain
TK90_RS00670	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TK90_RS00675	COG1392	Phosphate transport regulator
TK90_RS00680	COG0306	phosphate transporter
TK90_RS00685	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TK90_RS00690	COG0243	molybdopterin cofactor binding
TK90_RS00695	COG0437	4 iron, 4 sulfur cluster binding
TK90_RS00700	COG3302	dmso reductase anchor subunit
TK90_RS00735	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TK90_RS00745	COG2267	carboxylic ester hydrolase activity
TK90_RS00750	COG2226	methyltransferase
TK90_RS00755	COG3278	Belongs to the heme-copper respiratory oxidase family
TK90_RS00775	COG0348	domain, Protein
TK90_RS00800	COG2177	Part of the ABC transporter FtsEX involved in
TK90_RS00805	COG2884	Cell division ATP-binding protein ftsE
TK90_RS00810	COG0552	protein localization to endoplasmic reticulum
TK90_RS00815	COG0612	Peptidase, M16
TK90_RS00820	COG0612	Peptidase, M16
TK90_RS00840	COG0058	SHG alpha-glucan phosphorylase activity
TK90_RS00845	COG0151	Belongs to the GarS family
TK90_RS00850	COG0138	bifunctional purine biosynthesis protein purh
TK90_RS00865	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
TK90_RS00870	COG1410	methionine synthase
TK90_RS00870	COG0646	methionine synthase
TK90_RS00885	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TK90_RS00895	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TK90_RS00915	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TK90_RS00925	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TK90_RS00940	COG0004	ammonium transporteR
TK90_RS00945	COG1116	anion transmembrane transporter activity
TK90_RS00950	COG0390	transport system, permease component
TK90_RS00965	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TK90_RS00970	COG1166	arginine decarboxylase activity
TK90_RS00975	COG3100	YcgL domain-containing protein
TK90_RS00980	COG1217	gtp-binding protein TYPA
TK90_RS00985	COG3744	PilT protein domain protein
TK90_RS01015	COG4966	pilus assembly protein PilW
TK90_RS01080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TK90_RS01090	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TK90_RS01135	COG0446	pyridine nucleotide-disulphide oxidoreductase
TK90_RS01170	COG2205	protein histidine kinase activity
TK90_RS01175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TK90_RS01180	COG1643	Atp-dependent helicase
TK90_RS01190	COG0018	arginyl-trna synthetase
TK90_RS01195	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TK90_RS01205	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TK90_RS01220	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TK90_RS01225	COG1058	Belongs to the CinA family
TK90_RS01225	COG1546	Belongs to the CinA family
TK90_RS01235	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TK90_RS01270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TK90_RS01280	COG0069	glutamate synthase activity
TK90_RS01280	COG0067	glutamate synthase
TK90_RS01280	COG0070	glutamate synthase
TK90_RS01290	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TK90_RS01295	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TK90_RS01300	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TK90_RS01310	COG0493	'glutamate synthase
TK90_RS01315	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TK90_RS01355	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TK90_RS01375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TK90_RS01380	COG4232	protein-disulfide reductase activity
TK90_RS01405	COG3030	protein affecting phage T7 exclusion by the F plasmid
TK90_RS01410	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TK90_RS01415	COG0459	protein refolding
TK90_RS01430	COG2911	Protein conserved in bacteria
TK90_RS01435	COG0729	surface antigen
TK90_RS01440	COG3842	ATPase activity
TK90_RS01445	COG1178	ABC-type Fe3 transport system permease component
TK90_RS01450	COG1840	ABC-type Fe3 transport system, periplasmic component
TK90_RS01455	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TK90_RS01470	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TK90_RS01470	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TK90_RS01475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TK90_RS01490	COG0859	PFAM glycosyl transferase family 9
TK90_RS01495	COG1560	Kdo2-lipid A biosynthetic process
TK90_RS01505	COG1132	(ABC) transporter
TK90_RS01520	COG0297	glycogen (starch) synthase activity
TK90_RS01550	COG0438	transferase activity, transferring glycosyl groups
TK90_RS01555	COG0859	PFAM glycosyl transferase family 9
TK90_RS01565	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TK90_RS01570	COG1519	Transferase
TK90_RS01580	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
TK90_RS01590	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
TK90_RS01595	COG1792	Involved in formation and maintenance of cell shape
TK90_RS01600	COG1077	Cell shape determining protein MreB Mrl
TK90_RS01605	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TK90_RS01610	COG0154	amidase activity
TK90_RS01615	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TK90_RS01620	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TK90_RS01645	COG2890	protein-(glutamine-N5) methyltransferase activity
TK90_RS01650	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TK90_RS01655	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TK90_RS01665	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
TK90_RS01670	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TK90_RS01680	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TK90_RS01685	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TK90_RS01690	COG0193	aminoacyl-tRNA hydrolase activity
TK90_RS01695	COG0012	GTP binding
TK90_RS01700	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TK90_RS01715	COG0508	dehydrogenase complex catalyzes the overall conversion of
TK90_RS01720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TK90_RS01730	COG0137	argininosuccinate synthase activity
TK90_RS01735	COG3706	GGDEF domain
TK90_RS01740	COG2853	Lipoprotein
TK90_RS01750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TK90_RS01765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TK90_RS01785	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
TK90_RS01800	COG1137	ATPase activity
TK90_RS01805	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TK90_RS01825	COG1660	Displays ATPase and GTPase activities
TK90_RS01835	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TK90_RS01840	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TK90_RS01850	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TK90_RS01855	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TK90_RS01860	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TK90_RS01870	COG2854	intermembrane phospholipid transfer
TK90_RS01875	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TK90_RS01880	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TK90_RS01885	COG1127	ABC transporter
TK90_RS01895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TK90_RS01905	COG0730	response to heat
TK90_RS01910	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TK90_RS01915	COG0352	thiamine-phosphate diphosphorylase activity
TK90_RS01920	COG0352	thiamine-phosphate diphosphorylase activity
TK90_RS01920	COG0351	phosphomethylpyrimidine kinase
TK90_RS01935	COG0494	nUDIX hydrolase
TK90_RS01945	COG1981	membrane
TK90_RS01955	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TK90_RS01970	COG0316	Belongs to the HesB IscA family
TK90_RS01975	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
TK90_RS01980	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TK90_RS02020	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TK90_RS02025	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
TK90_RS02030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TK90_RS02040	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TK90_RS02045	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TK90_RS02055	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TK90_RS02060	COG0142	geranyltranstransferase activity
TK90_RS02065	COG1722	exodeoxyribonuclease VII activity
TK90_RS02070	COG1592	Rubrerythrin
TK90_RS02100	COG4536	flavin adenine dinucleotide binding
TK90_RS02105	COG4137	Cytochrome C assembly protein
TK90_RS02110	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TK90_RS02115	COG0228	four-way junction DNA binding
TK90_RS02120	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TK90_RS02125	COG0336	Belongs to the RNA methyltransferase TrmD family
TK90_RS02130	COG0335	large ribosomal subunit rRNA binding
TK90_RS02145	COG2010	Cytochrome c
TK90_RS02150	COG2010	Cytochrome c
TK90_RS02155	COG0326	Molecular chaperone. Has ATPase activity
TK90_RS02170	COG0811	peptide transport
TK90_RS02205	COG4771	TonB-dependent receptor
TK90_RS02245	COG2983	Belongs to the UPF0260 family
TK90_RS02255	COG0497	DNA recombination
TK90_RS02260	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TK90_RS02265	COG1420	regulation of RNA biosynthetic process
TK90_RS02270	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TK90_RS02275	COG0443	Heat shock 70 kDa protein
TK90_RS02280	COG0484	heat shock protein binding
TK90_RS02285	COG3706	GGDEF domain
TK90_RS02295	COG1509	lysine 2,3-aminomutase activity
TK90_RS02300	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TK90_RS02305	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
TK90_RS02310	COG2027	D-alanyl-D-alanine carboxypeptidase
TK90_RS02335	COG1028	Short-chain dehydrogenase reductase Sdr
TK90_RS02350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TK90_RS02370	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TK90_RS02385	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TK90_RS02395	COG0525	valine-tRNA ligase activity
TK90_RS02400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TK90_RS02405	COG3012	SEC-C Motif Domain Protein
TK90_RS02420	COG5002	protein histidine kinase activity
TK90_RS02420	COG5001	Diguanylate cyclase
TK90_RS02430	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TK90_RS02430	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TK90_RS02435	COG0802	atpase or kinase
TK90_RS02440	COG0860	N-Acetylmuramoyl-L-alanine amidase
TK90_RS02445	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TK90_RS02450	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TK90_RS02455	COG1923	regulation of RNA biosynthetic process
TK90_RS02460	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TK90_RS02465	COG1388	LysM domain
TK90_RS02465	COG0741	lytic transglycosylase activity
TK90_RS02475	COG0328	RNA-DNA hybrid ribonuclease activity
TK90_RS02485	COG3273	potassium ion transport
TK90_RS02485	COG0471	metal ion transport
TK90_RS02490	COG0442	prolyl-tRNA aminoacylation
TK90_RS02505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TK90_RS02520	COG0700	Nucleoside recognition
TK90_RS02525	COG0300	oxidoreductase activity
TK90_RS02545	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TK90_RS02575	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TK90_RS02625	COG3300	MHYT domain
TK90_RS02625	COG5001	Diguanylate cyclase
TK90_RS02630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TK90_RS02650	COG0501	Belongs to the peptidase M48B family
TK90_RS02655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TK90_RS02680	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TK90_RS02685	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TK90_RS02700	COG0247	lactate metabolic process
TK90_RS02715	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TK90_RS02720	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TK90_RS02725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TK90_RS02735	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TK90_RS02740	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TK90_RS02750	COG0628	permease
TK90_RS02770	COG1393	Belongs to the ArsC family
TK90_RS02775	COG1254	Belongs to the acylphosphatase family
TK90_RS02780	COG2255	four-way junction helicase activity
TK90_RS02785	COG0824	Thioesterase
TK90_RS02805	COG0823	Involved in the tonB-independent uptake of proteins
TK90_RS02820	COG0602	queuosine metabolic process
TK90_RS02825	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TK90_RS02830	COG2391	methyltransferase activity
TK90_RS02845	COG0544	peptidyl-prolyl cis-trans isomerase activity
TK90_RS02850	COG0740	serine-type endopeptidase activity
TK90_RS02855	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TK90_RS02860	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TK90_RS02885	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TK90_RS02895	COG0840	transmembrane signaling receptor activity
TK90_RS02905	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TK90_RS02930	COG2095	MarC family integral membrane protein
TK90_RS02945	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TK90_RS02950	COG0811	peptide transport
TK90_RS02965	COG1663	tetraacyldisaccharide 4'-kinase activity
TK90_RS02970	COG2835	tetraacyldisaccharide 4'-kinase activity
TK90_RS02975	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TK90_RS02980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TK90_RS02995	COG0601	transmembrane transport
TK90_RS03000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TK90_RS03005	COG4172	Belongs to the ABC transporter superfamily
TK90_RS03010	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TK90_RS03015	COG3706	GGDEF domain
TK90_RS03060	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TK90_RS03065	COG0438	transferase activity, transferring glycosyl groups
TK90_RS03070	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TK90_RS03100	COG1132	(ABC) transporter
TK90_RS03125	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TK90_RS03155	COG4783	chaperone-mediated protein folding
TK90_RS03165	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TK90_RS03170	COG0425	Belongs to the sulfur carrier protein TusA family
TK90_RS03200	COG2048	Heterodisulfide reductase, subunit B
TK90_RS03205	COG0509	glycine decarboxylation via glycine cleavage system
TK90_RS03215	COG0509	glycine decarboxylation via glycine cleavage system
TK90_RS03225	COG0095	Lipoate-protein ligase
TK90_RS03235	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TK90_RS03280	COG0123	including yeast histone deacetylase and acetoin utilization protein
TK90_RS03295	COG1160	GTP binding
TK90_RS03305	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TK90_RS03335	COG3707	response regulator
TK90_RS03340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TK90_RS03345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TK90_RS03350	COG1116	anion transmembrane transporter activity
TK90_RS03355	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TK90_RS03360	COG2146	nitrite reductase [NAD(P)H] activity
TK90_RS03365	COG0243	molybdopterin cofactor binding
TK90_RS03370	COG1648	precorrin-2 dehydrogenase activity
TK90_RS03370	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TK90_RS03380	COG1022	Amp-dependent synthetase and ligase
TK90_RS03395	COG0215	cysteine-tRNA ligase activity
TK90_RS03400	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TK90_RS03405	COG4251	negative regulation of phosphorylation
TK90_RS03410	COG0784	Response regulator, receiver
TK90_RS03425	COG0730	response to heat
TK90_RS03430	COG0523	cobalamin synthesis protein
TK90_RS03465	COG1131	(ABC) transporter
TK90_RS03480	COG2084	Dehydrogenase
TK90_RS03490	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
TK90_RS03510	COG0505	Belongs to the CarA family
TK90_RS03520	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TK90_RS03525	COG1534	Rna-binding protein
TK90_RS03530	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TK90_RS03540	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TK90_RS03545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TK90_RS03550	COG0149	triose-phosphate isomerase activity
TK90_RS03565	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TK90_RS03570	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TK90_RS03575	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TK90_RS03580	COG0649	NAD binding
TK90_RS03600	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TK90_RS03605	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TK90_RS03615	COG0713	ATP synthesis coupled electron transport
TK90_RS03630	COG1007	ATP synthesis coupled electron transport
TK90_RS03645	COG0779	Required for maturation of 30S ribosomal subunits
TK90_RS03650	COG0195	Participates in both transcription termination and antitermination
TK90_RS03650	COG2251	uridine kinase activity
TK90_RS03655	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TK90_RS03660	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TK90_RS03665	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TK90_RS03670	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TK90_RS03675	COG1185	polyribonucleotide nucleotidyltransferase activity
TK90_RS03685	COG0105	UTP biosynthetic process
TK90_RS03690	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TK90_RS03705	COG0124	histidyl-tRNA synthetase
TK90_RS03715	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TK90_RS03720	COG1160	GTP binding
TK90_RS03725	COG0436	Aminotransferase
TK90_RS03735	COG0733	neurotransmitter:sodium symporter activity
TK90_RS03740	COG0033	Phosphoglucomutase
TK90_RS03750	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TK90_RS03770	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TK90_RS03770	COG2111	Na H antiporter
TK90_RS03775	COG2111	Na H antiporter
TK90_RS03780	COG1006	Multisubunit Na H antiporter MnhC subunit
TK90_RS03785	COG0651	ATP synthesis coupled electron transport
TK90_RS03790	COG1863	multisubunit Na H antiporter MnhE subunit
TK90_RS03795	COG2212	antiporter activity
TK90_RS03800	COG1320	monovalent cation:proton antiporter activity
TK90_RS03810	COG0640	Transcriptional regulator
TK90_RS03815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TK90_RS03815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TK90_RS03835	COG1434	Gram-negative-bacterium-type cell wall biogenesis
TK90_RS03850	COG1295	ribonuclease BN
TK90_RS03855	COG2353	YceI-like domain
TK90_RS03875	COG0438	transferase activity, transferring glycosyl groups
TK90_RS03905	COG2210	Belongs to the sulfur carrier protein TusA family
TK90_RS03935	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TK90_RS03945	COG1193	negative regulation of DNA recombination
TK90_RS03960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TK90_RS03965	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TK90_RS03975	COG4206	TonB-dependent receptor
TK90_RS03980	COG2096	Adenosyltransferase
TK90_RS04005	COG1797	cobyrinic acid a,c-diamide synthase activity
TK90_RS04010	COG1648	precorrin-2 dehydrogenase activity
TK90_RS04010	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TK90_RS04015	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TK90_RS04020	COG1131	(ABC) transporter
TK90_RS04025	COG0842	Transport permease protein
TK90_RS04095	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TK90_RS04130	COG0415	Belongs to the DNA photolyase family
TK90_RS04135	COG3046	protein related to deoxyribodipyrimidine photolyase
TK90_RS04140	COG0789	Transcriptional regulator
TK90_RS04145	COG1331	Highly conserved protein containing a thioredoxin domain
TK90_RS04170	COG1045	serine acetyltransferase
TK90_RS04180	COG1104	cysteine desulfurase activity
TK90_RS04185	COG0822	iron-sulfur transferase activity
TK90_RS04190	COG0316	Belongs to the HesB IscA family
TK90_RS04195	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
TK90_RS04200	COG0443	Heat shock 70 kDa protein
TK90_RS04215	COG5265	(ABC) transporter
TK90_RS04225	COG0514	ATP-dependent DNA helicase (RecQ)
TK90_RS04240	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
TK90_RS04270	COG4191	Histidine kinase
TK90_RS04275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TK90_RS04280	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TK90_RS04285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TK90_RS04300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TK90_RS04305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TK90_RS04310	COG1850	ribulose-bisphosphate carboxylase activity
TK90_RS04315	COG4451	ribulose bisphosphate carboxylase, small
TK90_RS04340	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TK90_RS04345	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TK90_RS04350	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TK90_RS04355	COG2193	ferroxidase activity
TK90_RS04360	COG2154	pterin-4-alpha-carbinolamine dehydratase
TK90_RS04365	COG1192	Involved in chromosome partitioning
TK90_RS04385	COG0583	DNA-binding transcription factor activity
TK90_RS04405	COG0488	(ABC) transporter
TK90_RS04415	COG3002	Belongs to the UPF0753 family
TK90_RS04425	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TK90_RS04440	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TK90_RS04445	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TK90_RS04450	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TK90_RS04465	COG1965	Belongs to the frataxin family
TK90_RS04470	COG2363	Small membrane protein
TK90_RS04485	COG0742	ribosomal rna small subunit methyltransferase
TK90_RS04495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TK90_RS04520	COG2738	Putative neutral zinc metallopeptidase
TK90_RS04525	COG0668	transmembrane transport
TK90_RS04530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TK90_RS04550	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TK90_RS04565	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
TK90_RS04570	COG0398	Pfam SNARE associated Golgi protein
TK90_RS04580	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TK90_RS04585	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TK90_RS04590	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TK90_RS04595	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TK90_RS04600	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TK90_RS04605	COG0072	phenylalanine-tRNA ligase activity
TK90_RS04605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TK90_RS04610	COG0776	regulation of translation
TK90_RS04625	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
TK90_RS04645	COG0784	Response regulator, receiver
TK90_RS04645	COG0835	chemotaxis
TK90_RS04650	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TK90_RS04655	COG1815	bacterial-type flagellum-dependent cell motility
TK90_RS04660	COG1558	bacterial-type flagellum-dependent cell motility
TK90_RS04665	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TK90_RS04675	COG4787	bacterial-type flagellum-dependent cell motility
TK90_RS04680	COG4786	Flagellar basal body rod
TK90_RS04685	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TK90_RS04690	COG1706	bacterial-type flagellum-dependent cell motility
TK90_RS04705	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TK90_RS04725	COG0121	glutamine amidotransferase
TK90_RS04730	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
TK90_RS04735	COG2062	phosphohistidine phosphatase, SixA
TK90_RS04740	COG0248	Ppx GppA phosphatase
TK90_RS04745	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TK90_RS04750	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TK90_RS04755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TK90_RS04765	COG0471	metal ion transport
TK90_RS04770	COG0840	transmembrane signaling receptor activity
TK90_RS04790	COG0704	Plays a role in the regulation of phosphate uptake
TK90_RS04795	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TK90_RS04800	COG0573	inorganic phosphate transmembrane transporter activity
TK90_RS04805	COG0573	inorganic phosphate transmembrane transporter activity
TK90_RS04835	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
TK90_RS04840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TK90_RS04840	COG1116	anion transmembrane transporter activity
TK90_RS04845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TK90_RS04850	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TK90_RS04860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TK90_RS04865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TK90_RS04870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TK90_RS04870	COG1116	anion transmembrane transporter activity
TK90_RS04905	COG1196	nuclear chromosome segregation
TK90_RS04905	COG0741	lytic transglycosylase activity
TK90_RS04905	COG0739	heme binding
TK90_RS04915	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TK90_RS04940	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TK90_RS04960	COG4191	Histidine kinase
TK90_RS04970	COG2133	pyrroloquinoline quinone binding
TK90_RS05005	COG3706	GGDEF domain
TK90_RS05010	COG0277	FAD linked oxidase domain protein
TK90_RS05020	COG0651	ATP synthesis coupled electron transport
TK90_RS05025	COG0651	ATP synthesis coupled electron transport
TK90_RS05030	COG1007	ATP synthesis coupled electron transport
TK90_RS05045	COG1320	monovalent cation:proton antiporter activity
TK90_RS05085	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
TK90_RS05085	COG0392	lysyltransferase activity
TK90_RS05090	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TK90_RS05145	COG0322	excinuclease ABC activity
TK90_RS05155	COG5001	Diguanylate cyclase
TK90_RS05155	COG5002	protein histidine kinase activity
TK90_RS05165	COG0513	Belongs to the DEAD box helicase family
TK90_RS05175	COG1393	Belongs to the ArsC family
TK90_RS05180	COG2171	N-acyltransferase activity
TK90_RS05185	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TK90_RS05200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TK90_RS05225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TK90_RS05240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TK90_RS05255	COG0513	Belongs to the DEAD box helicase family
TK90_RS05275	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
TK90_RS05280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TK90_RS05290	COG0251	oxidation-reduction process
TK90_RS05295	COG2226	methyltransferase
TK90_RS05300	COG1872	DUF167
TK90_RS05305	COG0418	dihydroorotase activity
TK90_RS05315	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TK90_RS05340	COG1959	2 iron, 2 sulfur cluster binding
TK90_RS05345	COG1968	undecaprenyl-diphosphatase activity
TK90_RS05350	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
TK90_RS05355	COG4181	ATPase activity
TK90_RS05390	COG1704	LemA family
TK90_RS05395	COG0501	Belongs to the peptidase M48B family
TK90_RS05405	COG5001	Diguanylate cyclase
TK90_RS05415	COG0739	heme binding
TK90_RS05420	COG0842	Transport permease protein
TK90_RS05425	COG1131	(ABC) transporter
TK90_RS05430	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TK90_RS05460	COG3047	cAMP biosynthetic process
TK90_RS05485	COG3706	GGDEF domain
TK90_RS05495	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TK90_RS05500	COG0662	Cupin 2, conserved barrel domain protein
TK90_RS05500	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
TK90_RS05505	COG0587	DNA-directed DNA polymerase activity
TK90_RS05560	COG3093	addiction module antidote protein HigA
TK90_RS05565	COG2135	peptidase activity
TK90_RS05625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TK90_RS05670	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TK90_RS05715	COG2963	transposase activity
TK90_RS05720	COG2801	Transposase and inactivated derivatives
TK90_RS05740	COG0582	viral genome integration into host DNA
TK90_RS05760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TK90_RS05770	COG1714	RDD family
TK90_RS05775	COG3588	fructose-bisphosphate aldolase
TK90_RS05780	COG0737	Belongs to the 5'-nucleotidase family
TK90_RS05785	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
TK90_RS05790	COG0432	Pfam Uncharacterised protein family UPF0047
TK90_RS05845	COG3144	bacterial-type flagellum assembly
TK90_RS05880	COG1684	flagellar biosynthetic protein fliR
TK90_RS05915	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
TK90_RS05920	COG0643	Histidine kinase
TK90_RS05920	COG0784	Response regulator, receiver
TK90_RS05920	COG2198	Histidine kinase
TK90_RS05925	COG2201	protein-glutamate methylesterase activity
TK90_RS05930	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TK90_RS05935	COG1360	Flagellar Motor Protein
TK90_RS05940	COG1192	Involved in chromosome partitioning
TK90_RS05965	COG2257	FlhB HrpN YscU SpaS Family
TK90_RS05975	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TK90_RS05980	COG1530	ribonuclease E activity
TK90_RS05990	COG0546	phosphoglycolate phosphatase activity
TK90_RS05995	COG0616	signal peptide processing
TK90_RS06005	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TK90_RS06015	COG2957	Belongs to the agmatine deiminase family
TK90_RS06025	COG4591	ABC-type transport system involved in lipoprotein release permease component
TK90_RS06030	COG1136	(ABC) transporter
TK90_RS06040	COG0658	competence protein
TK90_RS06040	COG2333	competence protein COMEC
TK90_RS06045	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TK90_RS06055	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TK90_RS06060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TK90_RS06075	COG0287	Prephenate dehydrogenase
TK90_RS06080	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TK90_RS06105	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
TK90_RS06110	COG0284	orotidine-5'-phosphate decarboxylase activity
TK90_RS06115	COG1555	photosystem II stabilization
TK90_RS06115	COG1596	polysaccharide export
TK90_RS06120	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TK90_RS06130	COG0129	dihydroxy-acid dehydratase activity
TK90_RS06145	COG0235	Class ii aldolase
TK90_RS06150	COG3909	cytochrome
TK90_RS06155	COG2010	Cytochrome c
TK90_RS06190	COG0305	Participates in initiation and elongation during chromosome replication
TK90_RS06245	COG0436	Aminotransferase
TK90_RS06255	COG1472	Belongs to the glycosyl hydrolase 3 family
TK90_RS06265	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TK90_RS06270	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TK90_RS06295	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TK90_RS06310	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TK90_RS06315	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TK90_RS06320	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TK90_RS06325	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TK90_RS06330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TK90_RS06335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TK90_RS06350	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TK90_RS06355	COG0542	response to heat
TK90_RS06360	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TK90_RS06375	COG0482	sulfurtransferase activity
TK90_RS06380	COG2915	High frequency lysogenization protein hflD homolog
TK90_RS06415	COG2850	peptidyl-arginine hydroxylation
TK90_RS06420	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TK90_RS06425	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TK90_RS06435	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TK90_RS06440	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TK90_RS06445	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TK90_RS06445	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TK90_RS06450	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TK90_RS06460	COG0436	Aminotransferase
TK90_RS06475	COG4942	peptidase
TK90_RS06480	COG1238	metal cluster binding
TK90_RS06485	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TK90_RS06490	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TK90_RS06495	COG1193	negative regulation of DNA recombination
TK90_RS06510	COG1366	Belongs to the anti-sigma-factor antagonist family
TK90_RS06515	COG0585	pseudouridine synthase activity
TK90_RS06525	COG1199	ATP-dependent helicase activity
TK90_RS06535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TK90_RS06550	COG0791	NLP P60 protein
TK90_RS06560	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TK90_RS06565	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TK90_RS06570	COG1862	Preprotein translocase
TK90_RS06575	COG0343	queuine tRNA-ribosyltransferase activity
TK90_RS06580	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TK90_RS06630	COG3903	Transcriptional regulator
TK90_RS06630	COG2197	response regulator
TK90_RS06635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TK90_RS06650	COG0386	Belongs to the glutathione peroxidase family
TK90_RS06665	COG1127	ABC transporter
TK90_RS06670	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TK90_RS06675	COG0714	Associated with various cellular activities
TK90_RS06695	COG1376	ErfK ybiS ycfS ynhG family protein
TK90_RS06705	COG1286	toxin biosynthetic process
TK90_RS06715	COG0285	dihydrofolate synthase activity
TK90_RS06720	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TK90_RS06725	COG0159	tryptophan synthase activity
TK90_RS06730	COG0133	tryptophan synthase activity
TK90_RS06735	COG0135	phosphoribosylanthranilate isomerase activity
TK90_RS06740	COG0135	phosphoribosylanthranilate isomerase activity
TK90_RS06745	COG0101	tRNA pseudouridine synthase activity
TK90_RS06760	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TK90_RS06765	COG0473	3-isopropylmalate dehydrogenase activity
TK90_RS06775	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TK90_RS06795	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TK90_RS06800	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
TK90_RS06840	COG3706	GGDEF domain
TK90_RS06845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TK90_RS06850	COG0133	tryptophan synthase activity
TK90_RS06855	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TK90_RS06860	COG0123	including yeast histone deacetylase and acetoin utilization protein
TK90_RS06905	COG1446	asparaginase
TK90_RS06910	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
TK90_RS06945	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TK90_RS06950	COG0604	alcohol dehydrogenase
TK90_RS06960	COG3272	Protein of unknown function (DUF1722)
TK90_RS06965	COG1752	Esterase of the alpha-beta hydrolase superfamily
TK90_RS06985	COG3047	cAMP biosynthetic process
TK90_RS06985	COG2885	chlorophyll binding
TK90_RS07010	COG3237	CsbD-like
TK90_RS07030	COG1620	l-lactate permease
TK90_RS07065	COG2200	EAL domain
TK90_RS07065	COG2199	diguanylate cyclase activity
TK90_RS07065	COG2203	Gaf domain
TK90_RS07090	COG2249	NAD(P)H dehydrogenase (quinone) activity
TK90_RS07105	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TK90_RS07140	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TK90_RS07145	COG0537	adenosine 5'-monophosphoramidase activity
TK90_RS07155	COG2863	cytochrome
TK90_RS07170	COG3706	GGDEF domain
TK90_RS07170	COG2203	Gaf domain
TK90_RS07170	COG5001	Diguanylate cyclase
TK90_RS07170	COG4251	negative regulation of phosphorylation
TK90_RS07175	COG3706	GGDEF domain
TK90_RS07180	COG0477	Major facilitator Superfamily
TK90_RS07240	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TK90_RS07245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TK90_RS07245	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TK90_RS07250	COG0492	ferredoxin-NADP+ reductase activity
TK90_RS07265	COG1516	flagellar protein fliS
TK90_RS07295	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TK90_RS07305	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TK90_RS07315	COG1492	cobalamin metabolic process
TK90_RS07325	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TK90_RS07330	COG0778	Nitroreductase
TK90_RS07335	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TK90_RS07340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TK90_RS07345	COG1120	ATPase activity
TK90_RS07355	COG1741	Belongs to the pirin family
TK90_RS07360	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TK90_RS07370	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TK90_RS07375	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TK90_RS07380	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TK90_RS07385	COG0148	phosphopyruvate hydratase activity
TK90_RS07390	COG2877	3-deoxy-8-phosphooctulonate synthase activity
TK90_RS07395	COG0504	CTP synthase activity
TK90_RS07405	COG3706	GGDEF domain
TK90_RS07425	COG0037	tRNA processing
TK90_RS07430	COG0825	malonyl-CoA metabolic process
TK90_RS07440	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TK90_RS07445	COG0673	inositol 2-dehydrogenase activity
TK90_RS07455	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TK90_RS07460	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TK90_RS07465	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TK90_RS07480	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TK90_RS07495	COG0575	Belongs to the CDS family
TK90_RS07500	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TK90_RS07505	COG0233	cytoplasmic translational termination
TK90_RS07510	COG0528	UMP kinase activity
TK90_RS07515	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TK90_RS07520	COG0052	Belongs to the universal ribosomal protein uS2 family
TK90_RS07525	COG0024	Methionine aminopeptidase
TK90_RS07530	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
TK90_RS07555	COG5001	Diguanylate cyclase
TK90_RS07560	COG0655	NAD(P)H dehydrogenase (quinone) activity
TK90_RS07565	COG0402	S-adenosylhomocysteine deaminase activity
TK90_RS07570	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TK90_RS07580	COG1322	Protein conserved in bacteria
TK90_RS07585	COG1562	ergosterol biosynthetic process
TK90_RS07595	COG1562	ergosterol biosynthetic process
TK90_RS07600	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TK90_RS07625	COG0069	glutamate synthase activity
TK90_RS07625	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TK90_RS07630	COG0259	pyridoxamine-phosphate oxidase activity
TK90_RS07650	COG3795	YCII-related domain
TK90_RS07670	COG5507	3-demethylubiquinone-9 3-methyltransferase
TK90_RS07675	COG4941	Belongs to the sigma-70 factor family
TK90_RS07700	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TK90_RS07705	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TK90_RS07720	COG1487	ribonuclease activity
TK90_RS07755	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TK90_RS07760	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
TK90_RS07805	COG1216	Glycosyl transferase, family 2
TK90_RS07810	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TK90_RS07925	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TK90_RS07935	COG1196	nuclear chromosome segregation
TK90_RS07940	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TK90_RS07945	COG1070	Carbohydrate kinase
TK90_RS07955	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
TK90_RS07970	COG2770	Histidine kinase
TK90_RS07970	COG2208	phosphoserine phosphatase activity
TK90_RS07980	COG2146	nitrite reductase [NAD(P)H] activity
TK90_RS07995	COG1671	Belongs to the UPF0178 family
TK90_RS08005	COG4191	Histidine kinase
TK90_RS08025	COG2610	gluconate transmembrane transporter activity
TK90_RS08040	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TK90_RS08045	COG0322	excinuclease ABC activity
TK90_RS08050	COG1573	uracil-dna glycosylase
TK90_RS08055	COG2954	triphosphatase activity
TK90_RS08060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TK90_RS08065	COG0416	fatty acid biosynthetic process
TK90_RS08070	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TK90_RS08080	COG0439	Biotin carboxylase
TK90_RS08085	COG5016	pyruvate
TK90_RS08085	COG0511	ligase activity, forming carbon-carbon bonds
TK90_RS08090	COG0424	maF-like protein
TK90_RS08095	COG0640	Transcriptional regulator
TK90_RS08120	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TK90_RS08125	COG0527	aspartate kinase activity
TK90_RS08130	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TK90_RS08140	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TK90_RS08145	COG1546	Belongs to the CinA family
TK90_RS08155	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TK90_RS08175	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TK90_RS08180	COG1074	ATP-dependent DNA helicase activity
TK90_RS08185	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
TK90_RS08190	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
TK90_RS08205	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TK90_RS08220	COG3093	addiction module antidote protein HigA
TK90_RS08265	COG0469	pyruvate kinase activity
TK90_RS08280	COG3273	potassium ion transport
TK90_RS08280	COG0471	metal ion transport
TK90_RS08295	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TK90_RS08305	COG2814	Major facilitator Superfamily
TK90_RS08330	COG1970	mechanosensitive ion channel activity
TK90_RS08345	COG0494	nUDIX hydrolase
TK90_RS08350	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TK90_RS08390	COG5001	Diguanylate cyclase
TK90_RS08390	COG5002	protein histidine kinase activity
TK90_RS08410	COG3971	2-oxopent-4-enoate hydratase activity
TK90_RS08435	COG2308	Evidence 4 Homologs of previously reported genes of
TK90_RS08445	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TK90_RS08460	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TK90_RS08470	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TK90_RS08480	COG1943	Transposase
TK90_RS08495	COG0577	efflux transmembrane transporter activity
TK90_RS08500	COG1136	(ABC) transporter
TK90_RS08505	COG2239	Acts as a magnesium transporter
TK90_RS08510	COG2239	Acts as a magnesium transporter
TK90_RS08535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TK90_RS08585	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TK90_RS08590	COG1522	sequence-specific DNA binding
TK90_RS08595	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TK90_RS08600	COG1121	(ABC) transporter
TK90_RS08615	COG3706	GGDEF domain
TK90_RS08620	COG3706	GGDEF domain
TK90_RS08625	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TK90_RS08630	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
TK90_RS08635	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TK90_RS08640	COG0509	glycine decarboxylation via glycine cleavage system
TK90_RS08645	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TK90_RS08655	COG1115	amino acid carrier protein
TK90_RS08665	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TK90_RS08670	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TK90_RS08675	COG0180	Tryptophanyl-tRNA synthetase
TK90_RS08685	COG0009	L-threonylcarbamoyladenylate synthase
TK90_RS08690	COG2350	Protein conserved in bacteria
TK90_RS08695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TK90_RS08720	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TK90_RS08745	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TK90_RS08760	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TK90_RS08765	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TK90_RS08775	COG0509	glycine decarboxylation via glycine cleavage system
TK90_RS08810	COG1187	pseudouridine synthase activity
TK90_RS08815	COG0521	Mo-molybdopterin cofactor biosynthetic process
TK90_RS08830	COG0583	DNA-binding transcription factor activity
TK90_RS08840	COG0616	signal peptide processing
TK90_RS08870	COG0189	ligase activity
TK90_RS08870	COG4067	protein conserved in archaea
TK90_RS08875	COG0189	ligase activity
TK90_RS08885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TK90_RS08895	COG3038	cytochrome b561
TK90_RS08900	COG1011	Hydrolase
TK90_RS08915	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TK90_RS08925	COG0456	acetyltransferase
TK90_RS08930	COG1573	uracil-dna glycosylase
TK90_RS08935	COG1183	phosphatidylcholine synthase activity
TK90_RS08940	COG0688	phosphatidylethanolamine metabolic process
TK90_RS08945	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TK90_RS08950	COG0440	acetolactate synthase activity
TK90_RS08955	COG0028	Belongs to the TPP enzyme family
TK90_RS08965	COG0549	Belongs to the carbamate kinase family
TK90_RS08970	COG0717	Belongs to the dCTP deaminase family
TK90_RS08975	COG0489	protein tyrosine kinase activity
TK90_RS08980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TK90_RS08980	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TK90_RS08995	COG4657	Part of a membrane complex involved in electron transport
TK90_RS09000	COG2878	Part of a membrane complex involved in electron transport
TK90_RS09010	COG4658	electron transport chain
TK90_RS09020	COG4660	Part of a membrane complex involved in electron transport
TK90_RS09035	COG2233	PERMEase
TK90_RS09050	COG0386	Belongs to the glutathione peroxidase family
TK90_RS09130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TK90_RS09135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TK90_RS09140	COG0006	proline dipeptidase activity
TK90_RS09165	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TK90_RS09170	COG1674	ftsk spoiiie
TK90_RS09190	COG3263	regulation of cellular component size
TK90_RS09195	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TK90_RS09200	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TK90_RS09215	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TK90_RS09220	COG2894	cell division
TK90_RS09225	COG0850	regulation of cytokinetic process
TK90_RS09235	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TK90_RS09255	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TK90_RS09265	COG0688	phosphatidylethanolamine metabolic process
TK90_RS09270	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
TK90_RS09280	COG2154	pterin-4-alpha-carbinolamine dehydratase
TK90_RS09285	COG1162	GTPase activity
TK90_RS09295	COG0537	adenosine 5'-monophosphoramidase activity
TK90_RS09300	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TK90_RS09305	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TK90_RS09315	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
TK90_RS09315	COG0678	peroxiredoxin activity
TK90_RS09335	COG3237	CsbD-like
TK90_RS09360	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TK90_RS09375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TK90_RS09400	COG1366	Belongs to the anti-sigma-factor antagonist family
TK90_RS09415	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
TK90_RS09420	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TK90_RS09425	COG1053	succinate dehydrogenase
TK90_RS09430	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
TK90_RS09445	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TK90_RS09455	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TK90_RS09455	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TK90_RS09460	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TK90_RS09465	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TK90_RS09480	COG2358	TRAP transporter, solute receptor (TAXI family
TK90_RS09495	COG0277	FAD linked oxidase domain protein
TK90_RS09500	COG0247	lactate metabolic process
TK90_RS09505	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TK90_RS09540	COG1331	Highly conserved protein containing a thioredoxin domain
TK90_RS09545	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TK90_RS09550	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
TK90_RS09560	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TK90_RS09575	COG1458	PINc domain ribonuclease
TK90_RS09590	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TK90_RS09590	COG0519	Catalyzes the synthesis of GMP from XMP
TK90_RS09595	COG0517	IMP dehydrogenase activity
TK90_RS09595	COG0516	GMP reductase activity
TK90_RS09605	COG1570	exodeoxyribonuclease VII activity
TK90_RS09610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TK90_RS09615	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TK90_RS09620	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TK90_RS09640	COG1309	transcriptional regulator
TK90_RS09645	COG2833	Protein of unknown function (DUF455)
TK90_RS09655	COG2217	Heavy metal translocating P-type atpase
TK90_RS09665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TK90_RS09675	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TK90_RS09685	COG0359	binds to the 23S rRNA
TK90_RS09695	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TK90_RS09700	COG0360	Binds together with S18 to 16S ribosomal RNA
TK90_RS09710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TK90_RS09715	COG0557	exoribonuclease II activity
TK90_RS09725	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TK90_RS09730	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TK90_RS09735	COG0330	HflC and HflK could
TK90_RS09740	COG0330	HflC and HflK could
TK90_RS09745	COG0736	holo-[acyl-carrier-protein] synthase activity
TK90_RS09750	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TK90_RS09755	COG1381	Involved in DNA repair and RecF pathway recombination
TK90_RS09765	COG0571	ribonuclease III activity
TK90_RS09780	COG0481	GTPase activity
TK90_RS09790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TK90_RS09820	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TK90_RS09820	COG1017	nitric oxide dioxygenase activity
TK90_RS09825	COG3956	TIGRFAM MazG family protein
TK90_RS09830	COG3453	Protein conserved in bacteria
TK90_RS09830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TK90_RS09860	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TK90_RS09865	COG0321	lipoyl(octanoyl) transferase activity
TK90_RS09870	COG2921	Belongs to the UPF0250 family
TK90_RS09880	COG1686	Belongs to the peptidase S11 family
TK90_RS09890	COG2951	lytic endotransglycosylase activity
TK90_RS09895	COG0772	Belongs to the SEDS family
TK90_RS09900	COG0768	penicillin binding
TK90_RS09905	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TK90_RS09910	COG0563	adenylate kinase activity
TK90_RS09915	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
TK90_RS09920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TK90_RS09925	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TK90_RS09930	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TK90_RS09935	COG0837	glucose binding
TK90_RS09940	COG2967	ApaG domain
TK90_RS09945	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TK90_RS09950	COG0312	modulator of DNA gyrase
TK90_RS09960	COG0312	modulator of DNA gyrase
TK90_RS09965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TK90_RS10005	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TK90_RS10010	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TK90_RS10020	COG5001	Diguanylate cyclase
TK90_RS10020	COG3706	GGDEF domain
TK90_RS10020	COG4251	negative regulation of phosphorylation
TK90_RS10020	COG2203	Gaf domain
TK90_RS10030	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TK90_RS10035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TK90_RS10040	COG1758	RNA polymerase activity
TK90_RS10045	COG0194	GDP metabolic process
TK90_RS10055	COG0142	geranyltranstransferase activity
TK90_RS10060	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TK90_RS10065	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TK90_RS10070	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TK90_RS10075	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TK90_RS10085	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TK90_RS10090	COG2261	transglycosylase associated protein
TK90_RS10115	COG0632	four-way junction helicase activity
TK90_RS10120	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TK90_RS10125	COG0217	transcriptional regulatory protein
TK90_RS10135	COG0793	Belongs to the peptidase S41A family
TK90_RS10140	COG4942	peptidase
TK90_RS10150	COG1054	Belongs to the UPF0176 family
TK90_RS10160	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
TK90_RS10165	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TK90_RS10195	COG0542	response to heat
TK90_RS10205	COG0564	pseudouridine synthase activity
TK90_RS10215	COG0347	Belongs to the P(II) protein family
TK90_RS10225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TK90_RS10225	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TK90_RS10230	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TK90_RS10235	COG0045	succinate-CoA ligase (ADP-forming) activity
TK90_RS10240	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TK90_RS10245	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TK90_RS10250	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TK90_RS10255	COG1428	Deoxynucleoside kinase
TK90_RS10270	COG0494	nUDIX hydrolase
TK90_RS10275	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TK90_RS10285	COG0735	belongs to the Fur family
TK90_RS10290	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TK90_RS10295	COG2914	Belongs to the UPF0125 (RnfH) family
TK90_RS10300	COG2867	negative regulation of translational initiation
TK90_RS10305	COG0733	neurotransmitter:sodium symporter activity
TK90_RS10310	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TK90_RS10330	COG0628	permease
TK90_RS10340	COG1643	Atp-dependent helicase
TK90_RS10355	COG1136	(ABC) transporter
TK90_RS10400	COG0598	Magnesium transport protein CorA
TK90_RS10405	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
TK90_RS10425	COG2095	MarC family integral membrane protein
TK90_RS10455	COG0583	DNA-binding transcription factor activity
TK90_RS10460	COG2259	Doxx family
TK90_RS10465	COG1741	Belongs to the pirin family
TK90_RS10470	COG1741	Belongs to the pirin family
TK90_RS10480	COG1741	Belongs to the pirin family
TK90_RS10505	COG1902	pentaerythritol trinitrate reductase activity
TK90_RS10545	COG3118	belongs to the thioredoxin family
TK90_RS10570	COG0746	molybdenum cofactor guanylyltransferase activity
TK90_RS10575	COG1763	Mo-molybdopterin cofactor biosynthetic process
TK90_RS10580	COG0303	'Molybdopterin
TK90_RS10605	COG0795	lipopolysaccharide-transporting ATPase activity
TK90_RS10610	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TK90_RS10630	COG0166	Belongs to the GPI family
TK90_RS10635	COG0297	glycogen (starch) synthase activity
TK90_RS10640	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TK90_RS10660	COG0424	maF-like protein
TK90_RS10665	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TK90_RS10675	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TK90_RS10680	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TK90_RS10695	COG0495	leucyl-tRNA aminoacylation
TK90_RS10710	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TK90_RS10720	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TK90_RS10725	COG1702	phosphate starvation-inducible protein PhoH
TK90_RS10730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TK90_RS10740	COG2814	Major facilitator Superfamily
TK90_RS10750	COG0203	ribosomal protein L17
TK90_RS10755	COG0202	RNA polymerase activity
TK90_RS10760	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TK90_RS10765	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TK90_RS10770	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TK90_RS10775	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TK90_RS10780	COG0201	protein transport
TK90_RS10785	COG0200	Binds to the 23S rRNA
TK90_RS10790	COG1841	ribosomal large subunit assembly
TK90_RS10795	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TK90_RS10800	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TK90_RS10805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TK90_RS10810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TK90_RS10815	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TK90_RS10820	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TK90_RS10825	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TK90_RS10830	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TK90_RS10835	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TK90_RS10840	COG0255	Belongs to the universal ribosomal protein uL29 family
TK90_RS10845	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TK90_RS10850	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TK90_RS10855	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TK90_RS10860	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TK90_RS10865	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TK90_RS10870	COG0089	rRNA binding
TK90_RS10875	COG0088	Forms part of the polypeptide exit tunnel
TK90_RS10880	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TK90_RS10885	COG0051	transcription antitermination factor activity, RNA binding
TK90_RS10890	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TK90_RS10895	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TK90_RS10900	COG0049	tRNA binding
TK90_RS10905	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TK90_RS10910	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TK90_RS10915	COG0085	RNA polymerase activity
TK90_RS10920	COG0222	ribosome binding
TK90_RS10925	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TK90_RS10930	COG0081	regulation of translation
TK90_RS10935	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TK90_RS10945	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TK90_RS10955	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TK90_RS10990	COG0237	dephospho-CoA kinase activity
TK90_RS10995	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
TK90_RS11000	COG0494	nUDIX hydrolase
TK90_RS11005	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TK90_RS11010	COG0653	protein targeting
TK90_RS11025	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TK90_RS11030	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TK90_RS11040	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TK90_RS11045	COG1181	Belongs to the D-alanine--D-alanine ligase family
TK90_RS11050	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TK90_RS11055	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TK90_RS11060	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TK90_RS11065	COG0772	Belongs to the SEDS family
TK90_RS11070	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TK90_RS11075	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TK90_RS11080	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TK90_RS11085	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TK90_RS11095	COG3116	cell division
TK90_RS11100	COG0275	rRNA processing
TK90_RS11105	COG2001	Belongs to the MraZ family
TK90_RS11115	COG3107	peptidoglycan biosynthetic process
TK90_RS11120	COG0792	nuclease activity
TK90_RS11125	COG0277	FAD linked oxidase domain protein
TK90_RS11130	COG2969	positive regulation of protein catabolic process
TK90_RS11135	COG0625	glutathione transferase activity
TK90_RS11140	COG2857	Cytochrome c1
TK90_RS11145	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TK90_RS11150	COG0723	plastoquinol--plastocyanin reductase activity
TK90_RS11160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TK90_RS11190	COG0308	aminopeptidase N
TK90_RS11195	COG0084	hydrolase, TatD family'
TK90_RS11210	COG0189	ligase activity
TK90_RS11235	COG0271	Belongs to the BolA IbaG family
TK90_RS11250	COG1201	RNA secondary structure unwinding
TK90_RS11260	COG0511	ligase activity, forming carbon-carbon bonds
TK90_RS11265	COG0439	Biotin carboxylase
TK90_RS11270	COG2264	protein methyltransferase activity
TK90_RS11280	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TK90_RS11290	COG0483	inositol monophosphate 1-phosphatase activity
TK90_RS11320	COG0210	DNA helicase
TK90_RS11345	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TK90_RS11350	COG0756	dUTP diphosphatase activity
TK90_RS11355	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TK90_RS11360	COG2133	pyrroloquinoline quinone binding
TK90_RS11370	COG1560	Kdo2-lipid A biosynthetic process
TK90_RS11380	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TK90_RS11385	COG0569	domain protein
TK90_RS11390	COG2204	response regulator
TK90_RS11395	COG5000	phosphorelay sensor kinase activity
TK90_RS11405	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TK90_RS11410	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TK90_RS11415	COG0242	peptide deformylase activity
TK90_RS11425	COG0758	DNA mediated transformation
TK90_RS11430	COG2922	Belongs to the Smg family
TK90_RS11445	COG0408	coproporphyrinogen oxidase activity
TK90_RS11455	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TK90_RS11460	COG2885	chlorophyll binding
TK90_RS11465	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TK90_RS11470	COG1040	competence protein
TK90_RS11480	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TK90_RS11490	COG0156	8-amino-7-oxononanoate synthase activity
TK90_RS11500	COG2311	Membrane
TK90_RS11505	COG2003	Belongs to the UPF0758 family
TK90_RS11510	COG0129	dihydroxy-acid dehydratase activity
TK90_RS11525	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TK90_RS11525	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TK90_RS11540	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TK90_RS11545	COG3178	'Phosphotransferase
TK90_RS11550	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TK90_RS11610	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
TK90_RS11615	COG0438	transferase activity, transferring glycosyl groups
TK90_RS11645	COG5001	Diguanylate cyclase
TK90_RS11650	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TK90_RS11655	COG2814	Major facilitator Superfamily
TK90_RS11660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TK90_RS11665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TK90_RS11670	COG0435	Glutathione S-transferase
TK90_RS11675	COG2918	glutathione biosynthetic process
TK90_RS11680	COG3527	Alpha-acetolactate decarboxylase
TK90_RS11745	COG0488	(ABC) transporter
TK90_RS11755	COG0583	DNA-binding transcription factor activity
TK90_RS11765	COG0483	inositol monophosphate 1-phosphatase activity
TK90_RS11810	COG4566	intracellular signal transduction
TK90_RS11815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TK90_RS11815	COG3153	acetyltransferase
TK90_RS11830	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TK90_RS11835	COG1765	OsmC-like protein
TK90_RS11845	COG0134	indole-3-glycerol-phosphate synthase activity
TK90_RS11850	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TK90_RS11855	COG2814	Major facilitator Superfamily
TK90_RS11865	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TK90_RS11870	COG0546	phosphoglycolate phosphatase activity
TK90_RS11890	COG2813	Specifically methylates the guanine in position
TK90_RS11895	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TK90_RS11900	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TK90_RS11905	COG3001	Fructosamine kinase
TK90_RS11915	COG0741	lytic transglycosylase activity
TK90_RS11935	COG0039	L-malate dehydrogenase activity
TK90_RS11940	COG0281	malic enzyme
TK90_RS11955	COG0254	rRNA binding
TK90_RS11960	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TK90_RS11965	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TK90_RS11970	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TK90_RS11980	COG0191	fructose-bisphosphate aldolase activity
TK90_RS11985	COG0469	pyruvate kinase activity
TK90_RS11990	COG0126	phosphoglycerate kinase activity
TK90_RS11995	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TK90_RS12000	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TK90_RS12005	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TK90_RS12010	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TK90_RS12015	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TK90_RS12020	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TK90_RS12040	COG0835	chemotaxis
TK90_RS12055	COG0189	ligase activity
TK90_RS12080	COG1678	Uncharacterized ACR, COG1678
TK90_RS12085	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TK90_RS12095	COG0540	Belongs to the ATCase OTCase family
TK90_RS12105	COG0543	2 iron, 2 sulfur cluster binding
TK90_RS12140	COG0494	nUDIX hydrolase
TK90_RS12150	COG1011	Hydrolase
TK90_RS12160	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TK90_RS12185	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TK90_RS12190	COG0574	Belongs to the PEP-utilizing enzyme family
TK90_RS12190	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TK90_RS12195	COG0189	ligase activity
TK90_RS12195	COG4067	protein conserved in archaea
TK90_RS12210	COG0735	belongs to the Fur family
TK90_RS12230	COG1121	(ABC) transporter
TK90_RS12245	COG1469	GTP cyclohydrolase I activity
TK90_RS12255	COG0523	cobalamin synthesis protein
TK90_RS12310	COG1012	belongs to the aldehyde dehydrogenase family
TK90_RS12315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TK90_RS12320	COG0617	tRNA 3'-terminal CCA addition
TK90_RS12325	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TK90_RS12330	COG1538	Outer membrane efflux protein
TK90_RS12350	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
TK90_RS12360	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TK90_RS12365	COG2022	thiamine diphosphate biosynthetic process
TK90_RS12390	COG0513	Belongs to the DEAD box helicase family
TK90_RS12400	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TK90_RS12415	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TK90_RS12420	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TK90_RS12425	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TK90_RS12430	COG1561	YicC-like family, N-terminal region
TK90_RS12440	COG0071	Belongs to the small heat shock protein (HSP20) family
TK90_RS12450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TK90_RS12460	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
TK90_RS12465	COG0315	cyclic pyranopterin monophosphate synthase activity
TK90_RS12480	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
TK90_RS12515	COG0494	nUDIX hydrolase
TK90_RS12520	COG1061	Type III restriction enzyme res subunit
TK90_RS12540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TK90_RS12545	COG4191	Histidine kinase
TK90_RS12550	COG2204	response regulator
TK90_RS12560	COG2226	methyltransferase
TK90_RS12595	COG0489	protein tyrosine kinase activity
TK90_RS12605	COG3409	Peptidoglycan-binding domain 1 protein
TK90_RS12605	COG3267	Type II secretory pathway component ExeA
TK90_RS12635	COG0367	asparagine synthase
TK90_RS12645	COG0438	transferase activity, transferring glycosyl groups
TK90_RS12650	COG0438	transferase activity, transferring glycosyl groups
TK90_RS12665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TK90_RS12680	COG1215	transferase activity, transferring glycosyl groups
TK90_RS12695	COG1132	(ABC) transporter
TK90_RS12705	COG0318	PFAM AMP-dependent synthetase and ligase
TK90_RS12770	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TK90_RS12785	COG2226	methyltransferase
TK90_RS12810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TK90_RS12815	COG0788	formyltetrahydrofolate deformylase activity
TK90_RS12820	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TK90_RS12825	COG1047	Peptidyl-prolyl cis-trans
TK90_RS12835	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TK90_RS12840	COG0196	riboflavin kinase activity
TK90_RS12860	COG1444	tRNA N-acetyltransferase activity
TK90_RS12865	COG0840	transmembrane signaling receptor activity
TK90_RS12870	COG0488	(ABC) transporter
TK90_RS12875	COG0589	response to stress
TK90_RS12880	COG3273	potassium ion transport
TK90_RS12880	COG0471	metal ion transport
TK90_RS12900	COG0667	Aldo Keto reductase
TK90_RS12905	COG0084	hydrolase, TatD family'
TK90_RS12910	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TK90_RS12925	COG0751	glycine-tRNA ligase activity
TK90_RS12930	COG0752	glycyl-tRNA synthetase alpha subunit
TK90_RS12940	COG0174	glutamine synthetase
TK90_RS12950	COG0037	tRNA processing
TK90_RS12965	COG1490	D-aminoacyl-tRNA deacylase activity
TK90_RS12980	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TK90_RS12985	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TK90_RS12990	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TK90_RS12995	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TK90_RS13000	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TK90_RS13005	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TK90_RS13010	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TK90_RS13020	COG0356	it plays a direct role in the translocation of protons across the membrane
TK90_RS13030	COG1475	DNA binding
TK90_RS13035	COG1192	Involved in chromosome partitioning
TK90_RS13040	COG0357	Ribosomal RNA small subunit methyltransferase G
TK90_RS13045	COG0445	tRNA wobble uridine modification
TK90_RS13050	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TK90_RS13055	COG0706	membrane insertase activity
TK90_RS13060	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TK90_RS13065	COG0594	ribonuclease P activity
TK90_RS13070	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TK90_RS13140	COG0187	DNA topoisomerase II activity
TK90_RS13195	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TK90_RS13260	COG0165	Argininosuccinate lyase
TK90_RS13265	COG0165	Argininosuccinate lyase
TK90_RS13285	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
TK90_RS13310	COG0659	secondary active sulfate transmembrane transporter activity
TK90_RS13400	COG0367	asparagine synthase
TK90_RS13585	COG0243	molybdopterin cofactor binding
TK90_RS13795	COG0210	DNA helicase
TK90_RS14155	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TK90_RS14215	COG0646	methionine synthase
TK90_RS14215	COG1410	methionine synthase
TK90_RS14285	COG0390	transport system, permease component
TK90_RS14320	COG1217	gtp-binding protein TYPA
TK90_RS14420	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TK90_RS14500	COG0243	molybdopterin cofactor binding