locus-tag	class	description
TGR7_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TGR7_RS00010	COG0592	DNA-directed DNA polymerase activity
TGR7_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TGR7_RS00020	COG0187	DNA topoisomerase II activity
TGR7_RS00025	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TGR7_RS00030	COG0339	signal peptide processing
TGR7_RS00035	COG0708	Exodeoxyribonuclease III
TGR7_RS00040	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TGR7_RS00055	COG1942	4-Oxalocrotonate Tautomerase
TGR7_RS00065	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TGR7_RS00075	COG3123	guanosine phosphorylase activity
TGR7_RS00100	COG1238	metal cluster binding
TGR7_RS00110	COG2204	response regulator
TGR7_RS00125	COG0543	2 iron, 2 sulfur cluster binding
TGR7_RS00125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TGR7_RS00140	COG1587	Uroporphyrinogen-III synthase
TGR7_RS00145	COG0181	hydroxymethylbilane synthase activity
TGR7_RS00160	COG2972	Histidine kinase
TGR7_RS00160	COG0745	RESPONSE REGULATOR receiver
TGR7_RS00165	COG0165	Argininosuccinate lyase
TGR7_RS00170	COG5002	protein histidine kinase activity
TGR7_RS00170	COG5001	Diguanylate cyclase
TGR7_RS00175	COG0400	carboxylic ester hydrolase activity
TGR7_RS00195	COG3852	Histidine kinase
TGR7_RS00200	COG0019	diaminopimelate decarboxylase activity
TGR7_RS00205	COG4106	trans-aconitate 2-methyltransferase activity
TGR7_RS00220	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TGR7_RS00230	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TGR7_RS00235	COG0714	Associated with various cellular activities
TGR7_RS00255	COG2304	oxidoreductase activity
TGR7_RS00275	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TGR7_RS00280	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TGR7_RS00290	COG2226	methyltransferase
TGR7_RS00300	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TGR7_RS00305	COG0425	Belongs to the sulfur carrier protein TusA family
TGR7_RS00310	COG2391	methyltransferase activity
TGR7_RS00365	COG2204	response regulator
TGR7_RS00375	COG3706	GGDEF domain
TGR7_RS00385	COG0508	dehydrogenase complex catalyzes the overall conversion of
TGR7_RS00395	COG0210	DNA helicase
TGR7_RS00405	COG2198	Histidine kinase
TGR7_RS00405	COG2205	protein histidine kinase activity
TGR7_RS00405	COG0784	Response regulator, receiver
TGR7_RS00410	COG1024	Enoyl-CoA hydratase
TGR7_RS00415	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
TGR7_RS00425	COG1611	Belongs to the LOG family
TGR7_RS00435	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TGR7_RS00445	COG1333	cytochrome c biogenesis protein
TGR7_RS00450	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TGR7_RS00495	COG2003	Belongs to the UPF0758 family
TGR7_RS00505	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TGR7_RS00510	COG0756	dUTP diphosphatase activity
TGR7_RS00515	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TGR7_RS00535	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TGR7_RS00540	COG0708	Exodeoxyribonuclease III
TGR7_RS00545	COG2211	Major facilitator Superfamily
TGR7_RS00575	COG0408	coproporphyrinogen oxidase activity
TGR7_RS00580	COG5002	protein histidine kinase activity
TGR7_RS00580	COG5001	Diguanylate cyclase
TGR7_RS00590	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TGR7_RS00595	COG2885	chlorophyll binding
TGR7_RS00600	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TGR7_RS00610	COG1335	isochorismatase
TGR7_RS00620	COG0784	Response regulator, receiver
TGR7_RS00620	COG5002	protein histidine kinase activity
TGR7_RS00625	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TGR7_RS00635	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TGR7_RS00640	COG1040	competence protein
TGR7_RS00650	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TGR7_RS00660	COG0156	8-amino-7-oxononanoate synthase activity
TGR7_RS00675	COG1649	PFAM Uncharacterised BCR, COG1649
TGR7_RS00675	COG0726	polysaccharide deacetylase
TGR7_RS00715	COG0697	spore germination
TGR7_RS00755	COG3153	acetyltransferase
TGR7_RS00775	COG1201	RNA secondary structure unwinding
TGR7_RS00850	COG5002	protein histidine kinase activity
TGR7_RS00850	COG5001	Diguanylate cyclase
TGR7_RS00860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TGR7_RS00865	COG2719	SpoVR family
TGR7_RS00870	COG2718	Belongs to the UPF0229 family
TGR7_RS00875	COG2766	serine protein kinase
TGR7_RS00880	COG0438	transferase activity, transferring glycosyl groups
TGR7_RS00900	COG1335	isochorismatase
TGR7_RS00910	COG0540	Belongs to the ATCase OTCase family
TGR7_RS00915	COG0367	asparagine synthase
TGR7_RS00920	COG0668	transmembrane transport
TGR7_RS00930	COG3360	Dodecin
TGR7_RS00940	COG0009	L-threonylcarbamoyladenylate synthase
TGR7_RS00950	COG2922	Belongs to the Smg family
TGR7_RS00955	COG0758	DNA mediated transformation
TGR7_RS00965	COG0242	peptide deformylase activity
TGR7_RS00970	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TGR7_RS00985	COG5000	phosphorelay sensor kinase activity
TGR7_RS00990	COG2204	response regulator
TGR7_RS00995	COG0569	domain protein
TGR7_RS01000	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TGR7_RS01025	COG0037	tRNA processing
TGR7_RS01035	COG1490	D-aminoacyl-tRNA deacylase activity
TGR7_RS01040	COG0004	ammonium transporteR
TGR7_RS01050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TGR7_RS01055	COG0131	Imidazoleglycerol-phosphate dehydratase
TGR7_RS01065	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TGR7_RS01070	COG0107	imidazoleglycerol-phosphate synthase activity
TGR7_RS01075	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TGR7_RS01080	COG0140	phosphoribosyl-ATP diphosphatase activity
TGR7_RS01085	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TGR7_RS01090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TGR7_RS01100	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TGR7_RS01110	COG3031	protein transport across the cell outer membrane
TGR7_RS01195	COG4772	TonB-dependent receptor
TGR7_RS01215	COG5001	Diguanylate cyclase
TGR7_RS01215	COG5002	protein histidine kinase activity
TGR7_RS01240	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TGR7_RS01245	COG2226	methyltransferase
TGR7_RS01260	COG1643	Atp-dependent helicase
TGR7_RS01275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TGR7_RS01280	COG1067	ATP-dependent peptidase activity
TGR7_RS01290	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TGR7_RS01300	COG0018	arginyl-trna synthetase
TGR7_RS01310	COG1058	Belongs to the CinA family
TGR7_RS01310	COG1546	Belongs to the CinA family
TGR7_RS01315	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TGR7_RS01330	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TGR7_RS01345	COG2197	response regulator
TGR7_RS01360	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TGR7_RS01380	COG1752	Esterase of the alpha-beta hydrolase superfamily
TGR7_RS01390	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
TGR7_RS01395	COG0205	6-phosphofructokinase activity
TGR7_RS01415	COG1741	Belongs to the pirin family
TGR7_RS01420	COG0583	DNA-binding transcription factor activity
TGR7_RS01425	COG1741	Belongs to the pirin family
TGR7_RS01435	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TGR7_RS01440	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TGR7_RS01470	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TGR7_RS01475	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TGR7_RS01480	COG0405	Gamma-glutamyltransferase
TGR7_RS01485	COG1309	transcriptional regulator
TGR7_RS01505	COG0583	DNA-binding transcription factor activity
TGR7_RS01510	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TGR7_RS01530	COG4191	Histidine kinase
TGR7_RS01545	COG3258	Cytochrome c
TGR7_RS01565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TGR7_RS01570	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TGR7_RS01585	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
TGR7_RS01595	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TGR7_RS01600	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TGR7_RS01605	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TGR7_RS01610	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TGR7_RS01615	COG1028	Short-chain dehydrogenase reductase Sdr
TGR7_RS01625	COG1968	undecaprenyl-diphosphatase activity
TGR7_RS01630	COG0617	tRNA 3'-terminal CCA addition
TGR7_RS01635	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TGR7_RS01640	COG1012	belongs to the aldehyde dehydrogenase family
TGR7_RS01645	COG0586	Pfam SNARE associated Golgi protein
TGR7_RS01650	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TGR7_RS01655	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TGR7_RS01665	COG3302	dmso reductase anchor subunit
TGR7_RS01670	COG0437	4 iron, 4 sulfur cluster binding
TGR7_RS01675	COG0243	molybdopterin cofactor binding
TGR7_RS01710	COG1047	Peptidyl-prolyl cis-trans
TGR7_RS01735	COG2046	Belongs to the sulfate adenylyltransferase family
TGR7_RS01740	COG0563	adenylate kinase activity
TGR7_RS01745	COG0205	6-phosphofructokinase activity
TGR7_RS01765	COG0058	SHG alpha-glucan phosphorylase activity
TGR7_RS01770	COG0151	Belongs to the GarS family
TGR7_RS01775	COG0138	bifunctional purine biosynthesis protein purh
TGR7_RS01795	COG2920	part of a sulfur-relay system
TGR7_RS01800	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TGR7_RS01810	COG0439	Biotin carboxylase
TGR7_RS01815	COG0511	ligase activity, forming carbon-carbon bonds
TGR7_RS01820	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TGR7_RS01830	COG4232	protein-disulfide reductase activity
TGR7_RS01835	COG1324	tolerance protein
TGR7_RS01840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TGR7_RS02045	COG2842	Transposition protein
TGR7_RS02070	COG4396	Host-nuclease inhibitor protein Gam
TGR7_RS02145	COG2369	cell adhesion
TGR7_RS02155	COG3039	Transposase
TGR7_RS02165	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TGR7_RS02170	COG0459	protein refolding
TGR7_RS02190	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
TGR7_RS02200	COG0840	transmembrane signaling receptor activity
TGR7_RS02205	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TGR7_RS02220	COG0189	ligase activity
TGR7_RS02235	COG0189	ligase activity
TGR7_RS02235	COG4067	protein conserved in archaea
TGR7_RS02240	COG3842	ATPase activity
TGR7_RS02245	COG1178	ABC-type Fe3 transport system permease component
TGR7_RS02250	COG1840	ABC-type Fe3 transport system, periplasmic component
TGR7_RS02280	COG1595	DNA-templated transcription, initiation
TGR7_RS02285	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TGR7_RS02310	COG2226	methyltransferase
TGR7_RS02315	COG0789	Transcriptional regulator
TGR7_RS02360	COG3660	Nucleoside-diphosphate-sugar epimerase
TGR7_RS02370	COG1560	Kdo2-lipid A biosynthetic process
TGR7_RS02375	COG1519	Transferase
TGR7_RS02385	COG1538	Outer membrane efflux protein
TGR7_RS02405	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TGR7_RS02415	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TGR7_RS02415	COG0069	glutamate synthase activity
TGR7_RS02445	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
TGR7_RS02455	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
TGR7_RS02460	COG5002	protein histidine kinase activity
TGR7_RS02460	COG3447	MASE1 domain protein
TGR7_RS02460	COG5001	Diguanylate cyclase
TGR7_RS02465	COG0488	(ABC) transporter
TGR7_RS02505	COG1278	Cold shock
TGR7_RS02515	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
TGR7_RS02530	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
TGR7_RS02535	COG1792	Involved in formation and maintenance of cell shape
TGR7_RS02540	COG1077	Cell shape determining protein MreB Mrl
TGR7_RS02545	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TGR7_RS02550	COG0154	amidase activity
TGR7_RS02555	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TGR7_RS02560	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TGR7_RS02565	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TGR7_RS02580	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TGR7_RS02585	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TGR7_RS02595	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
TGR7_RS02600	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TGR7_RS02610	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TGR7_RS02615	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TGR7_RS02620	COG0193	aminoacyl-tRNA hydrolase activity
TGR7_RS02625	COG0012	GTP binding
TGR7_RS02720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TGR7_RS02745	COG1477	protein flavinylation
TGR7_RS02755	COG1446	asparaginase
TGR7_RS02790	COG1595	DNA-templated transcription, initiation
TGR7_RS02810	COG3178	'Phosphotransferase
TGR7_RS02840	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TGR7_RS02840	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TGR7_RS02855	COG0189	ligase activity
TGR7_RS02855	COG0569	domain protein
TGR7_RS02870	COG0129	dihydroxy-acid dehydratase activity
TGR7_RS02880	COG0840	transmembrane signaling receptor activity
TGR7_RS02895	COG3263	regulation of cellular component size
TGR7_RS02900	COG0826	peptidase U32
TGR7_RS02960	COG2205	protein histidine kinase activity
TGR7_RS02985	COG3586	endonuclease activity
TGR7_RS03000	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TGR7_RS03015	COG0659	secondary active sulfate transmembrane transporter activity
TGR7_RS03055	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TGR7_RS03060	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TGR7_RS03085	COG3177	Filamentation induced by cAMP protein fic
TGR7_RS03090	COG0531	amino acid
TGR7_RS03100	COG0210	DNA helicase
TGR7_RS03110	COG2026	Addiction module toxin, RelE StbE family
TGR7_RS03120	COG3023	N-Acetylmuramoyl-L-alanine amidase
TGR7_RS03125	COG3278	Belongs to the heme-copper respiratory oxidase family
TGR7_RS03140	COG2010	Cytochrome c
TGR7_RS03160	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TGR7_RS03180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TGR7_RS03185	COG0432	Pfam Uncharacterised protein family UPF0047
TGR7_RS03195	COG3300	MHYT domain
TGR7_RS03195	COG5001	Diguanylate cyclase
TGR7_RS03205	COG0483	inositol monophosphate 1-phosphatase activity
TGR7_RS03210	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
TGR7_RS03215	COG0646	methionine synthase
TGR7_RS03215	COG1410	methionine synthase
TGR7_RS03230	COG2831	hemolysin activation secretion protein
TGR7_RS03240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TGR7_RS03240	COG3153	acetyltransferase
TGR7_RS03265	COG0412	Dienelactone hydrolase
TGR7_RS03285	COG1643	Atp-dependent helicase
TGR7_RS03325	COG0483	inositol monophosphate 1-phosphatase activity
TGR7_RS03350	COG0583	DNA-binding transcription factor activity
TGR7_RS03385	COG2863	cytochrome
TGR7_RS03390	COG0446	pyridine nucleotide-disulphide oxidoreductase
TGR7_RS03410	COG0488	(ABC) transporter
TGR7_RS03420	COG2801	Transposase and inactivated derivatives
TGR7_RS03420	COG3415	Transposase
TGR7_RS03425	COG2095	MarC family integral membrane protein
TGR7_RS03430	COG1580	Controls the rotational direction of flagella during chemotaxis
TGR7_RS03440	COG2918	glutathione biosynthetic process
TGR7_RS03445	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TGR7_RS03445	COG4797	methyltransferase
TGR7_RS03455	COG2815	serine threonine protein kinase
TGR7_RS03455	COG0515	serine threonine protein kinase
TGR7_RS03465	COG2259	Doxx family
TGR7_RS03470	COG0435	Glutathione S-transferase
TGR7_RS03480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TGR7_RS03485	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TGR7_RS03490	COG5001	Diguanylate cyclase
TGR7_RS03490	COG3706	GGDEF domain
TGR7_RS03490	COG4251	negative regulation of phosphorylation
TGR7_RS03490	COG2203	Gaf domain
TGR7_RS03500	COG0438	transferase activity, transferring glycosyl groups
TGR7_RS03510	COG0271	Belongs to the BolA IbaG family
TGR7_RS03530	COG0308	aminopeptidase N
TGR7_RS03550	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TGR7_RS03560	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TGR7_RS03565	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TGR7_RS03565	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
TGR7_RS03570	COG1660	Displays ATPase and GTPase activities
TGR7_RS03575	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TGR7_RS03590	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TGR7_RS03595	COG1137	ATPase activity
TGR7_RS03610	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
TGR7_RS03645	COG1127	ABC transporter
TGR7_RS03650	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TGR7_RS03655	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TGR7_RS03670	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TGR7_RS03675	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TGR7_RS03690	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TGR7_RS03695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TGR7_RS03700	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TGR7_RS03705	COG0723	plastoquinol--plastocyanin reductase activity
TGR7_RS03710	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TGR7_RS03715	COG2857	Cytochrome c1
TGR7_RS03720	COG0625	glutathione transferase activity
TGR7_RS03725	COG2969	positive regulation of protein catabolic process
TGR7_RS03735	COG0277	FAD linked oxidase domain protein
TGR7_RS03740	COG0792	nuclease activity
TGR7_RS03745	COG3107	peptidoglycan biosynthetic process
TGR7_RS03760	COG2001	Belongs to the MraZ family
TGR7_RS03765	COG0275	rRNA processing
TGR7_RS03770	COG3116	cell division
TGR7_RS03780	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TGR7_RS03785	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TGR7_RS03790	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TGR7_RS03795	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TGR7_RS03800	COG0772	Belongs to the SEDS family
TGR7_RS03805	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TGR7_RS03810	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TGR7_RS03815	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TGR7_RS03820	COG1181	Belongs to the D-alanine--D-alanine ligase family
TGR7_RS03825	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TGR7_RS03835	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TGR7_RS03840	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TGR7_RS03850	COG0739	heme binding
TGR7_RS03855	COG0653	protein targeting
TGR7_RS03860	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TGR7_RS03865	COG0494	nUDIX hydrolase
TGR7_RS03875	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
TGR7_RS03880	COG0237	dephospho-CoA kinase activity
TGR7_RS03900	COG1132	(ABC) transporter
TGR7_RS03945	COG1115	amino acid carrier protein
TGR7_RS03970	COG0517	IMP dehydrogenase activity
TGR7_RS03990	COG0045	succinate-CoA ligase (ADP-forming) activity
TGR7_RS04000	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TGR7_RS04005	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TGR7_RS04005	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TGR7_RS04010	COG0347	Belongs to the P(II) protein family
TGR7_RS04015	COG0778	Nitroreductase
TGR7_RS04030	COG1496	oxidoreductase activity
TGR7_RS04035	COG0542	response to heat
TGR7_RS04070	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TGR7_RS04075	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TGR7_RS04080	COG2716	regulation of RNA biosynthetic process
TGR7_RS04085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TGR7_RS04090	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
TGR7_RS04095	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TGR7_RS04100	COG1469	GTP cyclohydrolase I activity
TGR7_RS04110	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TGR7_RS04115	COG0142	geranyltranstransferase activity
TGR7_RS04120	COG1722	exodeoxyribonuclease VII activity
TGR7_RS04125	COG1592	Rubrerythrin
TGR7_RS04160	COG4536	flavin adenine dinucleotide binding
TGR7_RS04165	COG4137	Cytochrome C assembly protein
TGR7_RS04170	COG1234	tRNA 3'-trailer cleavage
TGR7_RS04175	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TGR7_RS04180	COG0228	four-way junction DNA binding
TGR7_RS04185	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TGR7_RS04190	COG0336	Belongs to the RNA methyltransferase TrmD family
TGR7_RS04195	COG0335	large ribosomal subunit rRNA binding
TGR7_RS04205	COG0840	transmembrane signaling receptor activity
TGR7_RS04210	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TGR7_RS04215	COG3258	Cytochrome c
TGR7_RS04220	COG2010	Cytochrome c
TGR7_RS04225	COG3258	Cytochrome c
TGR7_RS04230	COG2010	Cytochrome c
TGR7_RS04235	COG3258	Cytochrome c
TGR7_RS04245	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
TGR7_RS04250	COG0326	Molecular chaperone. Has ATPase activity
TGR7_RS04275	COG4772	TonB-dependent receptor
TGR7_RS04280	COG0589	response to stress
TGR7_RS04285	COG0471	metal ion transport
TGR7_RS04285	COG0490	domain, Protein
TGR7_RS04305	COG0166	Belongs to the GPI family
TGR7_RS04310	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TGR7_RS04315	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TGR7_RS04320	COG0297	glycogen (starch) synthase activity
TGR7_RS04325	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TGR7_RS04335	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TGR7_RS04340	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TGR7_RS04345	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TGR7_RS04350	COG1428	Deoxynucleoside kinase
TGR7_RS04370	COG2816	NAD+ diphosphatase activity
TGR7_RS04375	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TGR7_RS04385	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
TGR7_RS04390	COG2983	Belongs to the UPF0260 family
TGR7_RS04415	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TGR7_RS04415	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TGR7_RS04420	COG0802	atpase or kinase
TGR7_RS04425	COG0860	N-Acetylmuramoyl-L-alanine amidase
TGR7_RS04430	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TGR7_RS04435	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TGR7_RS04440	COG1923	regulation of RNA biosynthetic process
TGR7_RS04445	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TGR7_RS04450	COG0330	HflC and HflK could
TGR7_RS04455	COG0330	HflC and HflK could
TGR7_RS04465	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TGR7_RS04470	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TGR7_RS04475	COG1028	Short-chain dehydrogenase reductase Sdr
TGR7_RS04505	COG3039	Transposase
TGR7_RS04560	COG0537	adenosine 5'-monophosphoramidase activity
TGR7_RS04575	COG0360	Binds together with S18 to 16S ribosomal RNA
TGR7_RS04580	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TGR7_RS04590	COG0359	binds to the 23S rRNA
TGR7_RS04600	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TGR7_RS04615	COG2379	hydroxypyruvate reductase
TGR7_RS04620	COG2833	Protein of unknown function (DUF455)
TGR7_RS04625	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TGR7_RS04630	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TGR7_RS04635	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TGR7_RS04640	COG0215	cysteine-tRNA ligase activity
TGR7_RS04645	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TGR7_RS04675	COG0544	peptidyl-prolyl cis-trans isomerase activity
TGR7_RS04680	COG0740	serine-type endopeptidase activity
TGR7_RS04685	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TGR7_RS04690	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TGR7_RS04720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TGR7_RS04735	COG0601	transmembrane transport
TGR7_RS04740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TGR7_RS04755	COG0631	protein serine/threonine phosphatase activity
TGR7_RS04760	COG0741	lytic transglycosylase activity
TGR7_RS04760	COG1388	LysM domain
TGR7_RS04800	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TGR7_RS04805	COG0733	neurotransmitter:sodium symporter activity
TGR7_RS04810	COG2867	negative regulation of translational initiation
TGR7_RS04815	COG2914	Belongs to the UPF0125 (RnfH) family
TGR7_RS04820	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TGR7_RS04825	COG0735	belongs to the Fur family
TGR7_RS04830	COG0497	DNA recombination
TGR7_RS04835	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TGR7_RS04840	COG1420	regulation of RNA biosynthetic process
TGR7_RS04845	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TGR7_RS04850	COG0443	Heat shock 70 kDa protein
TGR7_RS04855	COG0484	heat shock protein binding
TGR7_RS04860	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TGR7_RS04865	COG0505	Belongs to the CarA family
TGR7_RS04880	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TGR7_RS04890	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TGR7_RS04895	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TGR7_RS04900	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TGR7_RS04905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TGR7_RS04910	COG0149	triose-phosphate isomerase activity
TGR7_RS04925	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TGR7_RS04930	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TGR7_RS04935	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TGR7_RS04940	COG0649	NAD binding
TGR7_RS04955	COG1034	ATP synthesis coupled electron transport
TGR7_RS04960	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TGR7_RS04965	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TGR7_RS04975	COG0713	ATP synthesis coupled electron transport
TGR7_RS04990	COG1007	ATP synthesis coupled electron transport
TGR7_RS05005	COG0779	Required for maturation of 30S ribosomal subunits
TGR7_RS05010	COG2251	uridine kinase activity
TGR7_RS05010	COG0195	Participates in both transcription termination and antitermination
TGR7_RS05015	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TGR7_RS05020	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TGR7_RS05025	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TGR7_RS05030	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TGR7_RS05035	COG1185	polyribonucleotide nucleotidyltransferase activity
TGR7_RS05040	COG0429	hydrolase of the alpha beta-hydrolase fold
TGR7_RS05060	COG2308	Evidence 4 Homologs of previously reported genes of
TGR7_RS05075	COG2308	Evidence 4 Homologs of previously reported genes of
TGR7_RS05075	COG2307	Protein conserved in bacteria
TGR7_RS05100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TGR7_RS05115	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TGR7_RS05125	COG2176	DNA-directed DNA polymerase activity
TGR7_RS05150	COG3852	Histidine kinase
TGR7_RS05155	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TGR7_RS05160	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TGR7_RS05165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TGR7_RS05170	COG1570	exodeoxyribonuclease VII activity
TGR7_RS05180	COG0519	Catalyzes the synthesis of GMP from XMP
TGR7_RS05180	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TGR7_RS05210	COG3039	Transposase
TGR7_RS05215	COG0326	Molecular chaperone. Has ATPase activity
TGR7_RS05230	COG5001	Diguanylate cyclase
TGR7_RS05230	COG3300	MHYT domain
TGR7_RS05240	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TGR7_RS05250	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
TGR7_RS05255	COG2267	carboxylic ester hydrolase activity
TGR7_RS05270	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TGR7_RS05270	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TGR7_RS05275	COG0564	pseudouridine synthase activity
TGR7_RS05280	COG0330	HflC and HflK could
TGR7_RS05290	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TGR7_RS05300	COG4681	YaeQ
TGR7_RS05305	COG0700	Nucleoside recognition
TGR7_RS05310	COG1403	HNH endonuclease
TGR7_RS05315	COG3012	SEC-C Motif Domain Protein
TGR7_RS05320	COG0835	chemotaxis
TGR7_RS05320	COG0784	Response regulator, receiver
TGR7_RS05355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TGR7_RS05375	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TGR7_RS05380	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TGR7_RS05385	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TGR7_RS05390	COG0537	adenosine 5'-monophosphoramidase activity
TGR7_RS05410	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
TGR7_RS05435	COG3026	antisigma factor binding
TGR7_RS05445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TGR7_RS05455	COG0481	GTPase activity
TGR7_RS05460	COG0681	Belongs to the peptidase S26 family
TGR7_RS05470	COG0571	ribonuclease III activity
TGR7_RS05475	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TGR7_RS05480	COG1381	Involved in DNA repair and RecF pathway recombination
TGR7_RS05485	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TGR7_RS05490	COG0736	holo-[acyl-carrier-protein] synthase activity
TGR7_RS05495	COG0784	Response regulator, receiver
TGR7_RS05495	COG5002	protein histidine kinase activity
TGR7_RS05495	COG2205	protein histidine kinase activity
TGR7_RS05520	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TGR7_RS05535	COG3093	addiction module antidote protein HigA
TGR7_RS05545	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
TGR7_RS05555	COG0501	Belongs to the peptidase M48B family
TGR7_RS05580	COG5001	Diguanylate cyclase
TGR7_RS05580	COG5002	protein histidine kinase activity
TGR7_RS05585	COG0784	Response regulator, receiver
TGR7_RS05605	COG4269	membrane
TGR7_RS05610	COG0501	Belongs to the peptidase M48B family
TGR7_RS05635	COG0442	prolyl-tRNA aminoacylation
TGR7_RS05650	COG1566	PFAM secretion protein HlyD family protein
TGR7_RS05690	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TGR7_RS05710	COG0300	oxidoreductase activity
TGR7_RS05730	COG5001	Diguanylate cyclase
TGR7_RS05730	COG5002	protein histidine kinase activity
TGR7_RS05745	COG3064	Membrane
TGR7_RS05750	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TGR7_RS05755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TGR7_RS05760	COG1393	Belongs to the ArsC family
TGR7_RS05765	COG2171	N-acyltransferase activity
TGR7_RS05770	COG0436	Aminotransferase
TGR7_RS05785	COG3039	Transposase
TGR7_RS05790	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
TGR7_RS05795	COG0024	Methionine aminopeptidase
TGR7_RS05800	COG0052	Belongs to the universal ribosomal protein uS2 family
TGR7_RS05805	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TGR7_RS05810	COG0528	UMP kinase activity
TGR7_RS05815	COG0233	cytoplasmic translational termination
TGR7_RS05820	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TGR7_RS05825	COG0575	Belongs to the CDS family
TGR7_RS05830	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TGR7_RS05835	COG0750	zinc metalloprotease
TGR7_RS05840	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TGR7_RS05855	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TGR7_RS05860	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TGR7_RS05865	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TGR7_RS05875	COG0673	inositol 2-dehydrogenase activity
TGR7_RS05880	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TGR7_RS05890	COG0825	malonyl-CoA metabolic process
TGR7_RS05895	COG0037	tRNA processing
TGR7_RS05900	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TGR7_RS05915	COG0504	CTP synthase activity
TGR7_RS05920	COG2877	3-deoxy-8-phosphooctulonate synthase activity
TGR7_RS05925	COG0148	phosphopyruvate hydratase activity
TGR7_RS05930	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TGR7_RS05935	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TGR7_RS05940	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TGR7_RS05950	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TGR7_RS05965	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
TGR7_RS05975	COG1965	Belongs to the frataxin family
TGR7_RS05980	COG2363	Small membrane protein
TGR7_RS05985	COG1666	GTP binding
TGR7_RS06000	COG0742	ribosomal rna small subunit methyltransferase
TGR7_RS06005	COG2900	Belongs to the SlyX family
TGR7_RS06010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TGR7_RS06030	COG2132	Multicopper oxidase
TGR7_RS06060	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
TGR7_RS06080	COG0835	chemotaxis
TGR7_RS06080	COG0784	Response regulator, receiver
TGR7_RS06090	COG1815	bacterial-type flagellum-dependent cell motility
TGR7_RS06095	COG1558	bacterial-type flagellum-dependent cell motility
TGR7_RS06100	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TGR7_RS06105	COG1749	Flagellar hook protein flgE
TGR7_RS06110	COG4787	bacterial-type flagellum-dependent cell motility
TGR7_RS06120	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TGR7_RS06130	COG3951	Flagellar rod assembly protein muramidase FlgJ
TGR7_RS06130	COG1705	Flagellar rod assembly protein muramidase FlgJ
TGR7_RS06145	COG0235	Class ii aldolase
TGR7_RS06160	COG1509	lysine 2,3-aminomutase activity
TGR7_RS06165	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TGR7_RS06170	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
TGR7_RS06175	COG0688	phosphatidylethanolamine metabolic process
TGR7_RS06200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TGR7_RS06210	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TGR7_RS06230	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TGR7_RS06235	COG0066	3-isopropylmalate dehydratase activity
TGR7_RS06245	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TGR7_RS06260	COG0101	tRNA pseudouridine synthase activity
TGR7_RS06265	COG0135	phosphoribosylanthranilate isomerase activity
TGR7_RS06270	COG0133	tryptophan synthase activity
TGR7_RS06275	COG0159	tryptophan synthase activity
TGR7_RS06280	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TGR7_RS06285	COG0285	dihydrofolate synthase activity
TGR7_RS06295	COG1286	toxin biosynthetic process
TGR7_RS06305	COG1376	ErfK ybiS ycfS ynhG family protein
TGR7_RS06310	COG1177	transmembrane transport
TGR7_RS06315	COG1176	ABC-type spermidine putrescine transport system, permease component I
TGR7_RS06320	COG3842	ATPase activity
TGR7_RS06340	COG0247	lactate metabolic process
TGR7_RS06340	COG2181	nitrate reductase activity
TGR7_RS06370	COG0375	protein maturation
TGR7_RS06385	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TGR7_RS06410	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TGR7_RS06415	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TGR7_RS06430	COG1546	Belongs to the CinA family
TGR7_RS06435	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TGR7_RS06440	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TGR7_RS06445	COG2137	regulation of response to DNA damage stimulus
TGR7_RS06450	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TGR7_RS06455	COG0527	aspartate kinase activity
TGR7_RS06460	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TGR7_RS06485	COG2010	Cytochrome c
TGR7_RS06485	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TGR7_RS06510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TGR7_RS06520	COG0372	Belongs to the citrate synthase family
TGR7_RS06645	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TGR7_RS06675	COG1987	bacterial-type flagellum assembly
TGR7_RS06685	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TGR7_RS06690	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TGR7_RS06715	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
TGR7_RS06720	COG2198	Histidine kinase
TGR7_RS06720	COG0784	Response regulator, receiver
TGR7_RS06720	COG0643	Histidine kinase
TGR7_RS06730	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TGR7_RS06735	COG1360	Flagellar Motor Protein
TGR7_RS06740	COG1192	Involved in chromosome partitioning
TGR7_RS06750	COG0835	chemotaxis
TGR7_RS06775	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TGR7_RS06780	COG1530	ribonuclease E activity
TGR7_RS06795	COG0616	signal peptide processing
TGR7_RS06795	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TGR7_RS06805	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TGR7_RS06820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TGR7_RS06825	COG2957	Belongs to the agmatine deiminase family
TGR7_RS06835	COG1489	DNA binding
TGR7_RS06840	COG4591	ABC-type transport system involved in lipoprotein release permease component
TGR7_RS06845	COG1136	(ABC) transporter
TGR7_RS06855	COG0658	competence protein
TGR7_RS06855	COG2333	competence protein COMEC
TGR7_RS06860	COG0811	peptide transport
TGR7_RS06870	COG1132	(ABC) transporter
TGR7_RS06880	COG1663	tetraacyldisaccharide 4'-kinase activity
TGR7_RS06885	COG2835	tetraacyldisaccharide 4'-kinase activity
TGR7_RS06890	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TGR7_RS06900	COG0494	nUDIX hydrolase
TGR7_RS06910	COG3437	response regulator, receiver
TGR7_RS06915	COG3706	GGDEF domain
TGR7_RS06955	COG2211	Major facilitator Superfamily
TGR7_RS06960	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TGR7_RS06980	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TGR7_RS06985	COG0302	gtp cyclohydrolase
TGR7_RS06990	COG0415	Belongs to the DNA photolyase family
TGR7_RS06995	COG1028	Short-chain dehydrogenase reductase Sdr
TGR7_RS07000	COG3046	protein related to deoxyribodipyrimidine photolyase
TGR7_RS07010	COG4221	oxidoreductase activity
TGR7_RS07020	COG1331	Highly conserved protein containing a thioredoxin domain
TGR7_RS07030	COG1388	LysM domain
TGR7_RS07030	COG0791	NLP P60 protein
TGR7_RS07055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TGR7_RS07065	COG1199	ATP-dependent helicase activity
TGR7_RS07075	COG0585	pseudouridine synthase activity
TGR7_RS07080	COG1278	Cold shock
TGR7_RS07120	COG2203	Gaf domain
TGR7_RS07120	COG3706	GGDEF domain
TGR7_RS07120	COG5001	Diguanylate cyclase
TGR7_RS07120	COG4251	negative regulation of phosphorylation
TGR7_RS07145	COG0840	transmembrane signaling receptor activity
TGR7_RS07165	COG1366	Belongs to the anti-sigma-factor antagonist family
TGR7_RS07175	COG2840	Smr protein MutS2
TGR7_RS07180	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TGR7_RS07185	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TGR7_RS07210	COG0436	Aminotransferase
TGR7_RS07220	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TGR7_RS07240	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TGR7_RS07260	COG0488	(ABC) transporter
TGR7_RS07275	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TGR7_RS07280	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TGR7_RS07285	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TGR7_RS07290	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TGR7_RS07295	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TGR7_RS07300	COG0072	phenylalanine-tRNA ligase activity
TGR7_RS07305	COG0776	regulation of translation
TGR7_RS07330	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TGR7_RS07340	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TGR7_RS07350	COG2009	succinate dehydrogenase
TGR7_RS07355	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
TGR7_RS07360	COG1053	succinate dehydrogenase
TGR7_RS07380	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TGR7_RS07385	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TGR7_RS07390	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TGR7_RS07420	COG1136	(ABC) transporter
TGR7_RS07435	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
TGR7_RS07445	COG0033	Phosphoglucomutase
TGR7_RS07455	COG1959	2 iron, 2 sulfur cluster binding
TGR7_RS07460	COG1104	cysteine desulfurase activity
TGR7_RS07480	COG0714	Associated with various cellular activities
TGR7_RS07485	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TGR7_RS07495	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TGR7_RS07500	COG1127	ABC transporter
TGR7_RS07545	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
TGR7_RS07550	COG0604	alcohol dehydrogenase
TGR7_RS07560	COG2079	MmgE PrpD family protein
TGR7_RS07585	COG3243	poly(R)-hydroxyalkanoic acid synthase
TGR7_RS07600	COG1028	Short-chain dehydrogenase reductase Sdr
TGR7_RS07605	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
TGR7_RS07620	COG1028	Short-chain dehydrogenase reductase Sdr
TGR7_RS07635	COG1028	Short-chain dehydrogenase reductase Sdr
TGR7_RS07640	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TGR7_RS07645	COG1562	ergosterol biosynthetic process
TGR7_RS07665	COG1322	Protein conserved in bacteria
TGR7_RS07680	COG0402	S-adenosylhomocysteine deaminase activity
TGR7_RS07690	COG0668	transmembrane transport
TGR7_RS07695	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TGR7_RS07705	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TGR7_RS07710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TGR7_RS07715	COG0077	Prephenate dehydratase
TGR7_RS07715	COG1605	Chorismate mutase
TGR7_RS07725	COG0287	Prephenate dehydrogenase
TGR7_RS07730	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TGR7_RS07735	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TGR7_RS07740	COG0539	negative regulation of cytoplasmic translation
TGR7_RS07745	COG0776	regulation of translation
TGR7_RS07755	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
TGR7_RS07760	COG0284	orotidine-5'-phosphate decarboxylase activity
TGR7_RS07765	COG1596	polysaccharide export
TGR7_RS07765	COG1555	photosystem II stabilization
TGR7_RS07780	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TGR7_RS07785	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TGR7_RS07805	COG2358	TRAP transporter, solute receptor (TAXI family
TGR7_RS07810	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TGR7_RS07815	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TGR7_RS07820	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TGR7_RS07820	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TGR7_RS07835	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TGR7_RS07850	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TGR7_RS07870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TGR7_RS07895	COG2249	NAD(P)H dehydrogenase (quinone) activity
TGR7_RS07905	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TGR7_RS07910	COG4139	cobalamin transport
TGR7_RS07915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TGR7_RS07920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TGR7_RS07975	COG4243	Vitamin k epoxide reductase
TGR7_RS07985	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
TGR7_RS08000	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TGR7_RS08010	COG2208	phosphoserine phosphatase activity
TGR7_RS08025	COG5001	Diguanylate cyclase
TGR7_RS08025	COG4251	negative regulation of phosphorylation
TGR7_RS08025	COG3706	GGDEF domain
TGR7_RS08025	COG2203	Gaf domain
TGR7_RS08045	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TGR7_RS08050	COG0616	signal peptide processing
TGR7_RS08060	COG1704	LemA family
TGR7_RS08065	COG0501	Belongs to the peptidase M48B family
TGR7_RS08075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TGR7_RS08080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TGR7_RS08090	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
TGR7_RS08215	COG4397	Mu-like prophage major head subunit gpT
TGR7_RS08235	COG4383	Mu-like prophage protein gp29
TGR7_RS08240	COG4373	Mu-like prophage FluMu protein gp28
TGR7_RS08340	COG2842	Transposition protein
TGR7_RS08345	COG2801	Transposase and inactivated derivatives
TGR7_RS08390	COG0596	Alpha beta hydrolase
TGR7_RS08400	COG5001	Diguanylate cyclase
TGR7_RS08400	COG3447	MASE1 domain protein
TGR7_RS08400	COG5002	protein histidine kinase activity
TGR7_RS08415	COG0513	Belongs to the DEAD box helicase family
TGR7_RS08420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TGR7_RS08435	COG0583	DNA-binding transcription factor activity
TGR7_RS08440	COG0655	NAD(P)H dehydrogenase (quinone) activity
TGR7_RS08450	COG5265	(ABC) transporter
TGR7_RS08455	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TGR7_RS08485	COG0430	RNA-3'-phosphate cyclase activity
TGR7_RS08490	COG0788	formyltetrahydrofolate deformylase activity
TGR7_RS08505	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TGR7_RS08505	COG0446	pyridine nucleotide-disulphide oxidoreductase
TGR7_RS08520	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TGR7_RS08530	COG0069	glutamate synthase activity
TGR7_RS08560	COG2944	sequence-specific DNA binding
TGR7_RS08570	COG2226	methyltransferase
TGR7_RS08580	COG1595	DNA-templated transcription, initiation
TGR7_RS08590	COG3039	Transposase
TGR7_RS08595	COG2226	methyltransferase
TGR7_RS08610	COG2129	metallophosphoesterase
TGR7_RS08620	COG1509	lysine 2,3-aminomutase activity
TGR7_RS08640	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TGR7_RS08650	COG1228	amidohydrolase
TGR7_RS08660	COG0280	phosphate acetyltransferase
TGR7_RS08660	COG0281	malic enzyme
TGR7_RS08670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TGR7_RS08700	COG0446	pyridine nucleotide-disulphide oxidoreductase
TGR7_RS08710	COG2204	response regulator
TGR7_RS08760	COG2188	Transcriptional regulator
TGR7_RS08775	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TGR7_RS08785	COG1472	Belongs to the glycosyl hydrolase 3 family
TGR7_RS08805	COG1376	ErfK ybiS ycfS ynhG family protein
TGR7_RS08810	COG0556	nucleotide-excision repair
TGR7_RS08815	COG0436	Aminotransferase
TGR7_RS08840	COG0420	3'-5' exonuclease activity
TGR7_RS08885	COG1074	ATP-dependent DNA helicase activity
TGR7_RS08900	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TGR7_RS09020	COG1468	defense response to virus
TGR7_RS09020	COG1518	maintenance of DNA repeat elements
TGR7_RS09070	COG2135	peptidase activity
TGR7_RS09145	COG0084	hydrolase, TatD family'
TGR7_RS09160	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TGR7_RS09165	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TGR7_RS09175	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TGR7_RS09180	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TGR7_RS09185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TGR7_RS09190	COG1028	Short-chain dehydrogenase reductase Sdr
TGR7_RS09205	COG0542	response to heat
TGR7_RS09210	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TGR7_RS09225	COG0482	sulfurtransferase activity
TGR7_RS09230	COG2915	High frequency lysogenization protein hflD homolog
TGR7_RS09260	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TGR7_RS09265	COG2850	peptidyl-arginine hydroxylation
TGR7_RS09275	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TGR7_RS09280	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TGR7_RS09290	COG2205	protein histidine kinase activity
TGR7_RS09305	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TGR7_RS09310	COG1131	(ABC) transporter
TGR7_RS09315	COG0842	Transport permease protein
TGR7_RS09345	COG4804	nuclease activity
TGR7_RS09350	COG2003	Belongs to the UPF0758 family
TGR7_RS09370	COG1475	DNA binding
TGR7_RS09385	COG5489	Protein of unknown function (DUF736)
TGR7_RS09415	COG1192	Involved in chromosome partitioning
TGR7_RS09430	COG4959	Type IV secretory pathway protease TraF
TGR7_RS09440	COG0745	RESPONSE REGULATOR receiver
TGR7_RS09445	COG2205	protein histidine kinase activity
TGR7_RS09460	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
TGR7_RS09465	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TGR7_RS09475	COG0583	DNA-binding transcription factor activity
TGR7_RS09495	COG4962	Type ii secretion system protein e
TGR7_RS09500	COG3838	Conjugal transfer protein Trbc
TGR7_RS09510	COG3451	type IV secretory pathway VirB4
TGR7_RS09565	COG0322	excinuclease ABC activity
TGR7_RS09570	COG1573	uracil-dna glycosylase
TGR7_RS09575	COG2197	response regulator
TGR7_RS09580	COG2954	triphosphatase activity
TGR7_RS09585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TGR7_RS09590	COG0416	fatty acid biosynthetic process
TGR7_RS09595	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TGR7_RS09600	COG1399	metal-binding, possibly nucleic acid-binding protein
TGR7_RS09605	COG0439	Biotin carboxylase
TGR7_RS09615	COG0424	maF-like protein
TGR7_RS09625	COG0039	L-malate dehydrogenase activity
TGR7_RS09650	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TGR7_RS09655	COG0640	Transcriptional regulator
TGR7_RS09685	COG0514	ATP-dependent DNA helicase (RecQ)
TGR7_RS09695	COG2084	Dehydrogenase
TGR7_RS09700	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TGR7_RS09705	COG2894	cell division
TGR7_RS09710	COG0850	regulation of cytokinetic process
TGR7_RS09725	COG2161	toxin-antitoxin pair type II binding
TGR7_RS09730	COG4115	mRNA cleavage
TGR7_RS09805	COG3023	N-Acetylmuramoyl-L-alanine amidase
TGR7_RS09825	COG0398	Pfam SNARE associated Golgi protein
TGR7_RS09835	COG0640	Transcriptional regulator
TGR7_RS09840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TGR7_RS09955	COG2944	sequence-specific DNA binding
TGR7_RS09965	COG5001	Diguanylate cyclase
TGR7_RS09965	COG5002	protein histidine kinase activity
TGR7_RS09975	COG0598	Magnesium transport protein CorA
TGR7_RS09985	COG0577	efflux transmembrane transporter activity
TGR7_RS10010	COG0438	transferase activity, transferring glycosyl groups
TGR7_RS10015	COG2239	Acts as a magnesium transporter
TGR7_RS10020	COG2239	Acts as a magnesium transporter
TGR7_RS10025	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TGR7_RS10030	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TGR7_RS10035	COG1674	ftsk spoiiie
TGR7_RS10040	COG0686	Belongs to the AlaDH PNT family
TGR7_RS10045	COG0492	ferredoxin-NADP+ reductase activity
TGR7_RS10055	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
TGR7_RS10070	COG0521	Mo-molybdopterin cofactor biosynthetic process
TGR7_RS10075	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TGR7_RS10080	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TGR7_RS10085	COG0180	Tryptophanyl-tRNA synthetase
TGR7_RS10095	COG1994	Peptidase M50
TGR7_RS10100	COG0009	L-threonylcarbamoyladenylate synthase
TGR7_RS10105	COG2917	probably involved in intracellular septation
TGR7_RS10110	COG2350	Protein conserved in bacteria
TGR7_RS10115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TGR7_RS10125	COG1360	Flagellar Motor Protein
TGR7_RS10135	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TGR7_RS10150	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TGR7_RS10155	COG1070	Carbohydrate kinase
TGR7_RS10160	COG1073	alpha beta
TGR7_RS10170	COG1414	Transcriptional regulator
TGR7_RS10175	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TGR7_RS10200	COG0277	FAD linked oxidase domain protein
TGR7_RS10205	COG0277	FAD linked oxidase domain protein
TGR7_RS10210	COG0247	lactate metabolic process
TGR7_RS10220	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
TGR7_RS10225	COG1970	mechanosensitive ion channel activity
TGR7_RS10230	COG0436	Aminotransferase
TGR7_RS10235	COG0739	heme binding
TGR7_RS10240	COG1160	GTP binding
TGR7_RS10250	COG2976	Protein conserved in bacteria
TGR7_RS10255	COG0124	histidyl-tRNA synthetase
TGR7_RS10270	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TGR7_RS10275	COG0105	UTP biosynthetic process
TGR7_RS10300	COG0316	Belongs to the HesB IscA family
TGR7_RS10310	COG1104	cysteine desulfurase activity
TGR7_RS10315	COG1959	2 iron, 2 sulfur cluster binding
TGR7_RS10340	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TGR7_RS10345	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TGR7_RS10350	COG1862	Preprotein translocase
TGR7_RS10355	COG0343	queuine tRNA-ribosyltransferase activity
TGR7_RS10360	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TGR7_RS10385	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TGR7_RS10390	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TGR7_RS10400	COG1598	PFAM Uncharacterised protein family UPF0150
TGR7_RS10485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TGR7_RS10490	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
TGR7_RS10495	COG0297	glycogen (starch) synthase activity
TGR7_RS10520	COG3039	Transposase
TGR7_RS10555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TGR7_RS10580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TGR7_RS10585	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
TGR7_RS10590	COG4181	ATPase activity
TGR7_RS10600	COG0501	Belongs to the peptidase M48B family
TGR7_RS10620	COG3657	addiction module killer protein
TGR7_RS10630	COG1074	ATP-dependent DNA helicase activity
TGR7_RS10635	COG3118	belongs to the thioredoxin family
TGR7_RS10640	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TGR7_RS10665	COG1763	Mo-molybdopterin cofactor biosynthetic process
TGR7_RS10670	COG0303	'Molybdopterin
TGR7_RS10700	COG0795	lipopolysaccharide-transporting ATPase activity
TGR7_RS10705	COG0795	lipopolysaccharide-transporting ATPase activity
TGR7_RS10710	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TGR7_RS10730	COG0525	valine-tRNA ligase activity
TGR7_RS10740	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TGR7_RS10755	COG1595	DNA-templated transcription, initiation
TGR7_RS10765	COG0456	acetyltransferase
TGR7_RS10770	COG1573	uracil-dna glycosylase
TGR7_RS10775	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TGR7_RS10780	COG1183	phosphatidylcholine synthase activity
TGR7_RS10785	COG0688	phosphatidylethanolamine metabolic process
TGR7_RS10790	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TGR7_RS10800	COG0028	Belongs to the TPP enzyme family
TGR7_RS10805	COG1193	negative regulation of DNA recombination
TGR7_RS10820	COG0123	including yeast histone deacetylase and acetoin utilization protein
TGR7_RS10860	COG3850	Histidine kinase
TGR7_RS10865	COG2197	response regulator
TGR7_RS10875	COG1648	precorrin-2 dehydrogenase activity
TGR7_RS10875	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TGR7_RS10890	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TGR7_RS10935	COG2221	Nitrite and sulphite reductase 4Fe-4S
TGR7_RS10940	COG2221	Nitrite and sulphite reductase 4Fe-4S
TGR7_RS10945	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
TGR7_RS10950	COG2923	Belongs to the DsrF TusC family
TGR7_RS10960	COG2920	part of a sulfur-relay system
TGR7_RS10975	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TGR7_RS10975	COG0493	'glutamate synthase
TGR7_RS10995	COG1797	cobyrinic acid a,c-diamide synthase activity
TGR7_RS11000	COG0316	Belongs to the HesB IscA family
TGR7_RS11005	COG3128	pkhd-type hydroxylase
TGR7_RS11040	COG0095	Lipoate-protein ligase
TGR7_RS11050	COG0509	glycine decarboxylation via glycine cleavage system
TGR7_RS11060	COG0509	glycine decarboxylation via glycine cleavage system
TGR7_RS11065	COG2048	Heterodisulfide reductase, subunit B
TGR7_RS11095	COG0425	Belongs to the sulfur carrier protein TusA family
TGR7_RS11100	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TGR7_RS11110	COG4783	chaperone-mediated protein folding
TGR7_RS11140	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TGR7_RS11145	COG0602	queuosine metabolic process
TGR7_RS11160	COG0823	Involved in the tonB-independent uptake of proteins
TGR7_RS11175	COG0811	peptide transport
TGR7_RS11180	COG0824	Thioesterase
TGR7_RS11185	COG2255	four-way junction helicase activity
TGR7_RS11190	COG0632	four-way junction helicase activity
TGR7_RS11195	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TGR7_RS11200	COG0217	transcriptional regulatory protein
TGR7_RS11210	COG0494	nUDIX hydrolase
TGR7_RS11215	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TGR7_RS11230	COG1254	Belongs to the acylphosphatase family
TGR7_RS11245	COG1393	Belongs to the ArsC family
TGR7_RS11265	COG0628	permease
TGR7_RS11270	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TGR7_RS11280	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TGR7_RS11285	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TGR7_RS11295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TGR7_RS11315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TGR7_RS11330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TGR7_RS11335	COG0312	modulator of DNA gyrase
TGR7_RS11340	COG3028	Belongs to the UPF0307 family
TGR7_RS11350	COG0312	modulator of DNA gyrase
TGR7_RS11375	COG0424	maF-like protein
TGR7_RS11380	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TGR7_RS11390	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TGR7_RS11395	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TGR7_RS11400	COG1466	dna polymerase III delta subunit
TGR7_RS11410	COG0495	leucyl-tRNA aminoacylation
TGR7_RS11420	COG3447	MASE1 domain protein
TGR7_RS11420	COG5001	Diguanylate cyclase
TGR7_RS11420	COG5002	protein histidine kinase activity
TGR7_RS11450	COG0840	transmembrane signaling receptor activity
TGR7_RS11455	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TGR7_RS11460	COG4535	Mg2 and Co2 transporter CorC
TGR7_RS11465	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TGR7_RS11470	COG1702	phosphate starvation-inducible protein PhoH
TGR7_RS11475	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TGR7_RS11485	COG2814	Major facilitator Superfamily
TGR7_RS11510	COG0203	ribosomal protein L17
TGR7_RS11515	COG0202	RNA polymerase activity
TGR7_RS11520	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TGR7_RS11525	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TGR7_RS11530	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TGR7_RS11535	COG0201	protein transport
TGR7_RS11540	COG0200	Binds to the 23S rRNA
TGR7_RS11545	COG1841	ribosomal large subunit assembly
TGR7_RS11550	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TGR7_RS11555	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TGR7_RS11560	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TGR7_RS11565	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TGR7_RS11570	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TGR7_RS11575	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TGR7_RS11580	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TGR7_RS11585	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TGR7_RS11590	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TGR7_RS11595	COG0255	Belongs to the universal ribosomal protein uL29 family
TGR7_RS11600	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TGR7_RS11610	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TGR7_RS11615	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TGR7_RS11620	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TGR7_RS11625	COG0089	rRNA binding
TGR7_RS11630	COG0088	Forms part of the polypeptide exit tunnel
TGR7_RS11635	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TGR7_RS11640	COG0051	transcription antitermination factor activity, RNA binding
TGR7_RS11645	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TGR7_RS11650	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TGR7_RS11655	COG0049	tRNA binding
TGR7_RS11660	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TGR7_RS11665	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TGR7_RS11670	COG0085	RNA polymerase activity
TGR7_RS11675	COG0222	ribosome binding
TGR7_RS11680	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TGR7_RS11685	COG0081	regulation of translation
TGR7_RS11690	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TGR7_RS11710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TGR7_RS11755	COG1091	dTDP-4-dehydrorhamnose reductase activity
TGR7_RS11775	COG2852	Protein conserved in bacteria
TGR7_RS11780	COG2204	response regulator
TGR7_RS11805	COG1132	(ABC) transporter
TGR7_RS11825	COG0367	asparagine synthase
TGR7_RS11835	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TGR7_RS11850	COG0438	transferase activity, transferring glycosyl groups
TGR7_RS11880	COG0463	Glycosyl transferase, family 2
TGR7_RS11925	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TGR7_RS11925	COG2755	lipolytic protein G-D-S-L family
TGR7_RS11930	COG0438	transferase activity, transferring glycosyl groups
TGR7_RS11940	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TGR7_RS11945	COG2890	protein-(glutamine-N5) methyltransferase activity
TGR7_RS11950	COG0318	PFAM AMP-dependent synthetase and ligase
TGR7_RS11965	COG0367	asparagine synthase
TGR7_RS11980	COG0489	protein tyrosine kinase activity
TGR7_RS12005	COG2204	response regulator
TGR7_RS12030	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TGR7_RS12045	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TGR7_RS12055	COG0741	lytic transglycosylase activity
TGR7_RS12055	COG1196	nuclear chromosome segregation
TGR7_RS12055	COG0739	heme binding
TGR7_RS12085	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TGR7_RS12090	COG0739	heme binding
TGR7_RS12100	COG0316	Belongs to the HesB IscA family
TGR7_RS12115	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TGR7_RS12125	COG1981	membrane
TGR7_RS12135	COG0494	nUDIX hydrolase
TGR7_RS12150	COG1773	rubredoxin
TGR7_RS12155	COG0351	phosphomethylpyrimidine kinase
TGR7_RS12160	COG0352	thiamine-phosphate diphosphorylase activity
TGR7_RS12165	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TGR7_RS12170	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TGR7_RS12175	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TGR7_RS12180	COG0730	response to heat
TGR7_RS12190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TGR7_RS12215	COG0737	Belongs to the 5'-nucleotidase family
TGR7_RS12220	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TGR7_RS12225	COG1518	maintenance of DNA repeat elements
TGR7_RS12225	COG1468	defense response to virus
TGR7_RS12285	COG0653	protein targeting
TGR7_RS12295	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TGR7_RS12310	COG2853	Lipoprotein
TGR7_RS12315	COG5001	Diguanylate cyclase
TGR7_RS12315	COG5002	protein histidine kinase activity
TGR7_RS12315	COG3447	MASE1 domain protein
TGR7_RS12320	COG0137	argininosuccinate synthase activity
TGR7_RS12330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TGR7_RS12335	COG0508	dehydrogenase complex catalyzes the overall conversion of
TGR7_RS12340	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
TGR7_RS12345	COG0418	dihydroorotase activity
TGR7_RS12360	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TGR7_RS12365	COG0367	asparagine synthase
TGR7_RS12375	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TGR7_RS12380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TGR7_RS12385	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TGR7_RS12390	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TGR7_RS12395	COG0248	Ppx GppA phosphatase
TGR7_RS12410	COG0306	phosphate transporter
TGR7_RS12415	COG1392	Phosphate transport regulator
TGR7_RS12430	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
TGR7_RS12445	COG2095	MarC family integral membrane protein
TGR7_RS12460	COG5001	Diguanylate cyclase
TGR7_RS12460	COG3300	MHYT domain
TGR7_RS12465	COG3423	Transcriptional regulator
TGR7_RS12535	COG2204	response regulator
TGR7_RS12545	COG2205	protein histidine kinase activity
TGR7_RS12580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TGR7_RS12580	COG1017	nitric oxide dioxygenase activity
TGR7_RS12605	COG2010	Cytochrome c
TGR7_RS12615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TGR7_RS12645	COG2814	Major facilitator Superfamily
TGR7_RS12655	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TGR7_RS12660	COG0517	IMP dehydrogenase activity
TGR7_RS12665	COG1320	monovalent cation:proton antiporter activity
TGR7_RS12670	COG2212	antiporter activity
TGR7_RS12675	COG1863	multisubunit Na H antiporter MnhE subunit
TGR7_RS12680	COG0651	ATP synthesis coupled electron transport
TGR7_RS12685	COG1006	Multisubunit Na H antiporter MnhC subunit
TGR7_RS12695	COG2111	Na H antiporter
TGR7_RS12700	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TGR7_RS12700	COG2111	Na H antiporter
TGR7_RS12750	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TGR7_RS12800	COG1716	ATPase activity
TGR7_RS12800	COG1131	(ABC) transporter
TGR7_RS12800	COG0842	Transport permease protein
TGR7_RS12805	COG0583	DNA-binding transcription factor activity
TGR7_RS12810	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TGR7_RS12815	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TGR7_RS12825	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
TGR7_RS12845	COG0426	domain, Protein
TGR7_RS12845	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TGR7_RS12875	COG3901	Regulator of nitric oxide reductase transcription
TGR7_RS12875	COG0348	domain, Protein
TGR7_RS12880	COG4263	nitrous-oxide reductase activity
TGR7_RS12895	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
TGR7_RS12905	COG3604	Transcriptional regulator
TGR7_RS12950	COG2943	transferase activity, transferring hexosyl groups
TGR7_RS12970	COG2154	pterin-4-alpha-carbinolamine dehydratase
TGR7_RS12980	COG1671	Belongs to the UPF0178 family
TGR7_RS13015	COG2391	methyltransferase activity
TGR7_RS13035	COG0668	transmembrane transport
TGR7_RS13055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TGR7_RS13065	COG1993	acr, cog1993
TGR7_RS13085	COG0579	oxidoreductase
TGR7_RS13115	COG1227	inorganic diphosphatase activity
TGR7_RS13125	COG0676	glucose-6-phosphate 1-epimerase activity
TGR7_RS13140	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TGR7_RS13145	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TGR7_RS13145	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TGR7_RS13165	COG0519	Catalyzes the synthesis of GMP from XMP
TGR7_RS13170	COG0717	Belongs to the dCTP deaminase family
TGR7_RS13175	COG0489	protein tyrosine kinase activity
TGR7_RS13180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TGR7_RS13180	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TGR7_RS13185	COG0235	Class ii aldolase
TGR7_RS13190	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
TGR7_RS13195	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
TGR7_RS13200	COG4657	Part of a membrane complex involved in electron transport
TGR7_RS13205	COG2878	Part of a membrane complex involved in electron transport
TGR7_RS13215	COG4658	electron transport chain
TGR7_RS13220	COG4659	FMN binding
TGR7_RS13225	COG4660	Part of a membrane complex involved in electron transport
TGR7_RS13235	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TGR7_RS13240	COG1595	DNA-templated transcription, initiation
TGR7_RS13255	COG2259	Doxx family
TGR7_RS13265	COG0659	secondary active sulfate transmembrane transporter activity
TGR7_RS13275	COG3220	belongs to the UPF0276 family
TGR7_RS13295	COG2210	Belongs to the sulfur carrier protein TusA family
TGR7_RS13300	COG1940	carbohydrate kinase activity
TGR7_RS13305	COG2096	Adenosyltransferase
TGR7_RS13310	COG4206	TonB-dependent receptor
TGR7_RS13325	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TGR7_RS13330	COG0581	inorganic phosphate transmembrane transporter activity
TGR7_RS13375	COG0730	response to heat
TGR7_RS13380	COG2111	Na H antiporter
TGR7_RS13380	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TGR7_RS13385	COG0651	ATP synthesis coupled electron transport
TGR7_RS13390	COG0651	ATP synthesis coupled electron transport
TGR7_RS13410	COG1320	monovalent cation:proton antiporter activity
TGR7_RS13415	COG2212	antiporter activity
TGR7_RS13430	COG2361	Protein of unknown function DUF86
TGR7_RS13455	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
TGR7_RS13460	COG1628	Protein of unknown function DUF99
TGR7_RS13485	COG1355	regulation of microtubule-based process
TGR7_RS13510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TGR7_RS13525	COG0189	ligase activity
TGR7_RS13550	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TGR7_RS13560	COG1280	lysine exporter protein (LysE YggA)
TGR7_RS13565	COG4106	trans-aconitate 2-methyltransferase activity
TGR7_RS13580	COG0321	lipoyl(octanoyl) transferase activity
TGR7_RS13595	COG1686	Belongs to the peptidase S11 family
TGR7_RS13605	COG2951	lytic endotransglycosylase activity
TGR7_RS13610	COG0772	Belongs to the SEDS family
TGR7_RS13615	COG0768	penicillin binding
TGR7_RS13620	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TGR7_RS13625	COG0563	adenylate kinase activity
TGR7_RS13630	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
TGR7_RS13635	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TGR7_RS13640	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TGR7_RS13650	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TGR7_RS13655	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TGR7_RS13660	COG0363	glucosamine-6-phosphate deaminase activity
TGR7_RS13665	COG0837	glucose binding
TGR7_RS13670	COG2967	ApaG domain
TGR7_RS13695	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TGR7_RS13705	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TGR7_RS13720	COG0671	phosphoesterase, PA-phosphatase related
TGR7_RS13745	COG0426	domain, Protein
TGR7_RS13745	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TGR7_RS13755	COG2860	membrane
TGR7_RS13760	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TGR7_RS13775	COG1331	Highly conserved protein containing a thioredoxin domain
TGR7_RS13780	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TGR7_RS13785	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TGR7_RS13790	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
TGR7_RS13800	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TGR7_RS13825	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TGR7_RS13830	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TGR7_RS13835	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
TGR7_RS13840	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TGR7_RS13845	COG0509	glycine decarboxylation via glycine cleavage system
TGR7_RS13850	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TGR7_RS13860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TGR7_RS13865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TGR7_RS13870	COG0006	proline dipeptidase activity
TGR7_RS13895	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TGR7_RS13920	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TGR7_RS13925	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TGR7_RS13940	COG0247	lactate metabolic process
TGR7_RS13990	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TGR7_RS13995	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TGR7_RS14010	COG0247	lactate metabolic process
TGR7_RS14015	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
TGR7_RS14020	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TGR7_RS14030	COG1765	OsmC-like protein
TGR7_RS14040	COG0134	indole-3-glycerol-phosphate synthase activity
TGR7_RS14045	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TGR7_RS14050	COG2814	Major facilitator Superfamily
TGR7_RS14085	COG0583	DNA-binding transcription factor activity
TGR7_RS14095	COG0789	Transcriptional regulator
TGR7_RS14105	COG2226	methyltransferase
TGR7_RS14165	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TGR7_RS14185	COG0798	PFAM Bile acid sodium symporter
TGR7_RS14195	COG0346	lactoylglutathione lyase activity
TGR7_RS14200	COG0640	Transcriptional regulator
TGR7_RS14285	COG3039	Transposase
TGR7_RS14300	COG1074	ATP-dependent DNA helicase activity
TGR7_RS14355	COG2003	Belongs to the UPF0758 family
TGR7_RS14425	COG0582	viral genome integration into host DNA
TGR7_RS14440	COG0546	phosphoglycolate phosphatase activity
TGR7_RS14445	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TGR7_RS14465	COG2813	Specifically methylates the guanine in position
TGR7_RS14470	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TGR7_RS14475	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TGR7_RS14480	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TGR7_RS14485	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TGR7_RS14495	COG0191	fructose-bisphosphate aldolase activity
TGR7_RS14500	COG0469	pyruvate kinase activity
TGR7_RS14505	COG0126	phosphoglycerate kinase activity
TGR7_RS14510	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TGR7_RS14520	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TGR7_RS14525	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TGR7_RS14540	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TGR7_RS14550	COG2198	Histidine kinase
TGR7_RS14550	COG0784	Response regulator, receiver
TGR7_RS14550	COG0643	Histidine kinase
TGR7_RS14555	COG0840	transmembrane signaling receptor activity
TGR7_RS14575	COG0189	ligase activity
TGR7_RS14600	COG1678	Uncharacterized ACR, COG1678
TGR7_RS14605	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TGR7_RS14610	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TGR7_RS14615	COG0540	Belongs to the ATCase OTCase family
TGR7_RS14625	COG0543	2 iron, 2 sulfur cluster binding
TGR7_RS14670	COG0776	regulation of translation
TGR7_RS14680	COG3785	DNA binding
TGR7_RS14685	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TGR7_RS14700	COG1011	Hydrolase
TGR7_RS14705	COG0494	nUDIX hydrolase
TGR7_RS14710	COG1218	3'(2'),5'-bisphosphate nucleotidase
TGR7_RS14715	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TGR7_RS14725	COG0189	ligase activity
TGR7_RS14725	COG4067	protein conserved in archaea
TGR7_RS14775	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
TGR7_RS14780	COG1194	a g-specific adenine glycosylase
TGR7_RS14805	COG0315	cyclic pyranopterin monophosphate synthase activity
TGR7_RS14810	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
TGR7_RS14835	COG0071	Belongs to the small heat shock protein (HSP20) family
TGR7_RS14845	COG1561	YicC-like family, N-terminal region
TGR7_RS14850	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TGR7_RS14855	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TGR7_RS14865	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TGR7_RS14880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TGR7_RS14885	COG0254	rRNA binding
TGR7_RS14895	COG0501	Belongs to the peptidase M48B family
TGR7_RS14900	COG0281	malic enzyme
TGR7_RS14905	COG0039	L-malate dehydrogenase activity
TGR7_RS14920	COG0523	cobalamin synthesis protein
TGR7_RS14960	COG3001	Fructosamine kinase
TGR7_RS14965	COG3264	Mechanosensitive ion channel
TGR7_RS14965	COG1511	domain protein
TGR7_RS14970	COG2084	Dehydrogenase
TGR7_RS14975	COG0742	ribosomal rna small subunit methyltransferase
TGR7_RS14980	COG0612	Peptidase, M16
TGR7_RS14985	COG0612	Peptidase, M16
TGR7_RS14990	COG0552	protein localization to endoplasmic reticulum
TGR7_RS14995	COG2884	Cell division ATP-binding protein ftsE
TGR7_RS15000	COG2177	Part of the ABC transporter FtsEX involved in
TGR7_RS15015	COG2217	Heavy metal translocating P-type atpase
TGR7_RS15025	COG0348	domain, Protein
TGR7_RS15030	COG2010	Cytochrome c
TGR7_RS15045	COG3278	Belongs to the heme-copper respiratory oxidase family
TGR7_RS15050	COG1612	heme a metabolic process
TGR7_RS15055	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TGR7_RS15060	COG0109	protoheme IX farnesyltransferase activity
TGR7_RS15085	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
TGR7_RS15090	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TGR7_RS15095	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TGR7_RS15105	COG2226	methyltransferase
TGR7_RS15110	COG2267	carboxylic ester hydrolase activity
TGR7_RS15115	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TGR7_RS15120	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TGR7_RS15125	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TGR7_RS15130	COG1610	YqeY-like protein
TGR7_RS15135	COG0493	'glutamate synthase
TGR7_RS15140	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TGR7_RS15165	COG3039	Transposase
TGR7_RS15185	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TGR7_RS15190	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TGR7_RS15195	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TGR7_RS15205	COG0067	glutamate synthase
TGR7_RS15205	COG0069	glutamate synthase activity
TGR7_RS15205	COG0070	glutamate synthase
TGR7_RS15250	COG2267	carboxylic ester hydrolase activity
TGR7_RS15290	COG0446	pyridine nucleotide-disulphide oxidoreductase
TGR7_RS15305	COG1121	(ABC) transporter
TGR7_RS15320	COG0735	belongs to the Fur family
TGR7_RS15330	COG1192	Involved in chromosome partitioning
TGR7_RS15335	COG1022	Amp-dependent synthetase and ligase
TGR7_RS15345	COG2067	long-chain fatty acid transport protein
TGR7_RS15355	COG0604	alcohol dehydrogenase
TGR7_RS15365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TGR7_RS15365	COG0045	succinate-CoA ligase (ADP-forming) activity
TGR7_RS15365	COG1042	CoA-binding domain protein
TGR7_RS15390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TGR7_RS15395	COG2738	Putative neutral zinc metallopeptidase
TGR7_RS15405	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TGR7_RS15415	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TGR7_RS15420	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TGR7_RS15470	COG1116	anion transmembrane transporter activity
TGR7_RS15495	COG3665	Urea carboxylase-associated protein
TGR7_RS15500	COG0439	Biotin carboxylase
TGR7_RS15520	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TGR7_RS15530	COG0463	Glycosyl transferase, family 2
TGR7_RS15535	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TGR7_RS15560	COG0829	nickel cation binding
TGR7_RS15565	COG0831	urea catabolic process
TGR7_RS15570	COG0832	Belongs to the urease beta subunit family
TGR7_RS15575	COG0804	urea catabolic process
TGR7_RS15580	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
TGR7_RS15585	COG0830	nickel cation binding
TGR7_RS15590	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TGR7_RS15640	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TGR7_RS15650	COG0347	Belongs to the P(II) protein family
TGR7_RS15655	COG0004	ammonium transporteR
TGR7_RS15665	COG0390	transport system, permease component
TGR7_RS15670	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TGR7_RS15675	COG1166	arginine decarboxylase activity
TGR7_RS15685	COG3100	YcgL domain-containing protein
TGR7_RS15700	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TGR7_RS15725	COG0509	glycine decarboxylation via glycine cleavage system
TGR7_RS15770	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TGR7_RS15785	COG2346	COG2346, Truncated hemoglobins
TGR7_RS15790	COG1217	gtp-binding protein TYPA
TGR7_RS15795	COG0745	RESPONSE REGULATOR receiver
TGR7_RS15805	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TGR7_RS15830	COG2133	pyrroloquinoline quinone binding
TGR7_RS15835	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TGR7_RS15845	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TGR7_RS15870	COG0247	lactate metabolic process
TGR7_RS15875	COG1139	Iron-sulfur cluster binding protein
TGR7_RS15900	COG3384	dioxygenase
TGR7_RS15920	COG1620	l-lactate permease
TGR7_RS15930	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TGR7_RS15940	COG0469	pyruvate kinase activity
TGR7_RS15945	COG1515	deoxyribonuclease V activity
TGR7_RS15950	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
TGR7_RS15965	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TGR7_RS15975	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TGR7_RS15980	COG1758	RNA polymerase activity
TGR7_RS16010	COG1192	Involved in chromosome partitioning
TGR7_RS16020	COG2193	ferroxidase activity
TGR7_RS16025	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TGR7_RS16030	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TGR7_RS16035	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TGR7_RS16065	COG1850	ribulose-bisphosphate carboxylase activity
TGR7_RS16080	COG0142	geranyltranstransferase activity
TGR7_RS16085	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TGR7_RS16090	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TGR7_RS16095	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TGR7_RS16100	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TGR7_RS16105	COG0268	Binds directly to 16S ribosomal RNA
TGR7_RS16125	COG0196	riboflavin kinase activity
TGR7_RS16130	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TGR7_RS16140	COG1047	Peptidyl-prolyl cis-trans
TGR7_RS16145	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TGR7_RS16195	COG4969	Belongs to the N-Me-Phe pilin family
TGR7_RS16240	COG2022	thiamine diphosphate biosynthetic process
TGR7_RS16245	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TGR7_RS16255	COG3273	potassium ion transport
TGR7_RS16255	COG0471	metal ion transport
TGR7_RS16275	COG0667	Aldo Keto reductase
TGR7_RS16300	COG0084	hydrolase, TatD family'
TGR7_RS16305	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TGR7_RS16310	COG5001	Diguanylate cyclase
TGR7_RS16310	COG5002	protein histidine kinase activity
TGR7_RS16330	COG0751	glycine-tRNA ligase activity
TGR7_RS16345	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TGR7_RS16350	COG0174	glutamine synthetase
TGR7_RS16360	COG3852	Histidine kinase
TGR7_RS16365	COG2204	response regulator
TGR7_RS16390	COG2165	general secretion pathway protein
TGR7_RS16395	COG2165	general secretion pathway protein
TGR7_RS16400	COG2165	general secretion pathway protein
TGR7_RS16405	COG1459	type II secretion system
TGR7_RS16410	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TGR7_RS16420	COG3267	Type II secretory pathway component ExeA
TGR7_RS16420	COG3409	Peptidoglycan-binding domain 1 protein
TGR7_RS16455	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TGR7_RS16460	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TGR7_RS16465	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
TGR7_RS16480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TGR7_RS16490	COG4942	peptidase
TGR7_RS16495	COG0793	Belongs to the peptidase S41A family
TGR7_RS16500	COG2861	carbohydrate metabolic process
TGR7_RS16505	COG0693	protein deglycase activity
TGR7_RS16510	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
TGR7_RS16560	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TGR7_RS16565	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TGR7_RS16570	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TGR7_RS16575	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TGR7_RS16580	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TGR7_RS16585	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TGR7_RS16590	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TGR7_RS16595	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TGR7_RS16605	COG0356	it plays a direct role in the translocation of protons across the membrane
TGR7_RS16610	COG3312	ion transport
TGR7_RS16615	COG1475	DNA binding
TGR7_RS16620	COG1192	Involved in chromosome partitioning
TGR7_RS16625	COG0357	Ribosomal RNA small subunit methyltransferase G
TGR7_RS16630	COG0445	tRNA wobble uridine modification
TGR7_RS16635	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TGR7_RS16640	COG0706	membrane insertase activity
TGR7_RS16645	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TGR7_RS16650	COG0594	ribonuclease P activity
TGR7_RS16655	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TGR7_RS16690	COG1555	photosystem II stabilization
TGR7_RS16740	COG4251	negative regulation of phosphorylation
TGR7_RS16750	COG4251	negative regulation of phosphorylation
TGR7_RS16800	COG0438	transferase activity, transferring glycosyl groups
TGR7_RS16805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TGR7_RS16810	COG1216	Glycosyl transferase, family 2
TGR7_RS16825	COG1216	Glycosyl transferase, family 2
TGR7_RS16830	COG3409	Peptidoglycan-binding domain 1 protein
TGR7_RS16830	COG3267	Type II secretory pathway component ExeA
TGR7_RS16845	COG1760	l-serine dehydratase
TGR7_RS16885	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis