locus-tag	class	description
TBD_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TBD_RS00020	COG3871	stress protein (general stress protein 26)
TBD_RS00025	COG0776	regulation of translation
TBD_RS00045	COG2922	Belongs to the Smg family
TBD_RS00050	COG0758	DNA mediated transformation
TBD_RS00060	COG0242	peptide deformylase activity
TBD_RS00065	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TBD_RS00080	COG5000	phosphorelay sensor kinase activity
TBD_RS00085	COG2204	response regulator
TBD_RS00090	COG0569	domain protein
TBD_RS00100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TBD_RS00110	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
TBD_RS00115	COG0704	Plays a role in the regulation of phosphate uptake
TBD_RS00125	COG0494	nUDIX hydrolase
TBD_RS00135	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TBD_RS00155	COG1074	ATP-dependent DNA helicase activity
TBD_RS00165	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TBD_RS00175	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TBD_RS00180	COG0254	rRNA binding
TBD_RS00185	COG0501	Belongs to the peptidase M48B family
TBD_RS00205	COG0247	lactate metabolic process
TBD_RS00215	COG0277	FAD linked oxidase domain protein
TBD_RS00220	COG0277	FAD linked oxidase domain protein
TBD_RS00235	COG1414	Transcriptional regulator
TBD_RS00270	COG2827	Endonuclease containing a URI domain
TBD_RS00275	COG1752	Esterase of the alpha-beta hydrolase superfamily
TBD_RS00285	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
TBD_RS00290	COG0367	asparagine synthase
TBD_RS00295	COG2951	lytic endotransglycosylase activity
TBD_RS00330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TBD_RS00335	COG0010	Belongs to the arginase family
TBD_RS00345	COG0535	radical SAM domain protein
TBD_RS00360	COG1522	sequence-specific DNA binding
TBD_RS00395	COG2084	Dehydrogenase
TBD_RS00405	COG1686	Belongs to the peptidase S11 family
TBD_RS00435	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TBD_RS00440	COG2176	DNA-directed DNA polymerase activity
TBD_RS00450	COG0459	protein refolding
TBD_RS00455	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TBD_RS00470	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TBD_RS00480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TBD_RS00490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TBD_RS00500	COG2027	D-alanyl-D-alanine carboxypeptidase
TBD_RS00505	COG3134	Outer membrane lipoprotein
TBD_RS00510	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TBD_RS00515	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TBD_RS00520	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TBD_RS00525	COG2823	Periplasmic or secreted lipoprotein
TBD_RS00530	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TBD_RS00535	COG0792	nuclease activity
TBD_RS00545	COG0418	dihydroorotase activity
TBD_RS00550	COG2001	Belongs to the MraZ family
TBD_RS00555	COG0275	rRNA processing
TBD_RS00560	COG3116	cell division
TBD_RS00570	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TBD_RS00575	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TBD_RS00580	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TBD_RS00585	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TBD_RS00590	COG0772	Belongs to the SEDS family
TBD_RS00595	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TBD_RS00600	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TBD_RS00605	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TBD_RS00610	COG1181	Belongs to the D-alanine--D-alanine ligase family
TBD_RS00625	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TBD_RS00630	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TBD_RS00640	COG2885	chlorophyll binding
TBD_RS00640	COG3047	cAMP biosynthetic process
TBD_RS00645	COG3258	Cytochrome c
TBD_RS00650	COG2863	cytochrome
TBD_RS00660	COG0653	protein targeting
TBD_RS00680	COG0642	Histidine kinase
TBD_RS00705	COG1368	sulfuric ester hydrolase activity
TBD_RS00735	COG3245	cytochrome
TBD_RS00750	COG3001	Fructosamine kinase
TBD_RS00765	COG0488	(ABC) transporter
TBD_RS00770	COG5002	protein histidine kinase activity
TBD_RS00770	COG5001	Diguanylate cyclase
TBD_RS00780	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TBD_RS00780	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TBD_RS00785	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TBD_RS00805	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TBD_RS00810	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TBD_RS00815	COG0126	phosphoglycerate kinase activity
TBD_RS00820	COG0469	pyruvate kinase activity
TBD_RS00825	COG0191	fructose-bisphosphate aldolase activity
TBD_RS00850	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TBD_RS00865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TBD_RS00875	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TBD_RS00880	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
TBD_RS00890	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TBD_RS00895	COG0509	glycine decarboxylation via glycine cleavage system
TBD_RS00900	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TBD_RS00910	COG2264	protein methyltransferase activity
TBD_RS00915	COG0439	Biotin carboxylase
TBD_RS00920	COG0511	ligase activity, forming carbon-carbon bonds
TBD_RS00925	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TBD_RS00930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TBD_RS00935	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TBD_RS00940	COG1333	cytochrome c biogenesis protein
TBD_RS00950	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TBD_RS00965	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TBD_RS00990	COG2204	response regulator
TBD_RS00995	COG2205	protein histidine kinase activity
TBD_RS00995	COG2198	Histidine kinase
TBD_RS00995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TBD_RS00995	COG0784	Response regulator, receiver
TBD_RS01000	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TBD_RS01040	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TBD_RS01055	COG0529	Catalyzes the synthesis of activated sulfate
TBD_RS01055	COG2046	Belongs to the sulfate adenylyltransferase family
TBD_RS01070	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TBD_RS01080	COG2226	methyltransferase
TBD_RS01085	COG0745	RESPONSE REGULATOR receiver
TBD_RS01100	COG0277	FAD linked oxidase domain protein
TBD_RS01105	COG2354	Protein conserved in bacteria
TBD_RS01110	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TBD_RS01115	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TBD_RS01120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TBD_RS01140	COG1965	Belongs to the frataxin family
TBD_RS01150	COG0165	Argininosuccinate lyase
TBD_RS01185	COG0606	chelatase, subunit chli
TBD_RS01205	COG0004	ammonium transporteR
TBD_RS01210	COG0302	gtp cyclohydrolase
TBD_RS01220	COG2885	chlorophyll binding
TBD_RS01230	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
TBD_RS01235	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TBD_RS01240	COG1127	ABC transporter
TBD_RS01265	COG2211	Major facilitator Superfamily
TBD_RS01270	COG0708	Exodeoxyribonuclease III
TBD_RS01275	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TBD_RS01285	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TBD_RS01290	COG0154	amidase activity
TBD_RS01295	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TBD_RS01300	COG1077	Cell shape determining protein MreB Mrl
TBD_RS01310	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
TBD_RS01315	COG0768	penicillin binding
TBD_RS01320	COG0772	Belongs to the SEDS family
TBD_RS01330	COG1686	Belongs to the peptidase S11 family
TBD_RS01340	COG2921	Belongs to the UPF0250 family
TBD_RS01345	COG0321	lipoyl(octanoyl) transferase activity
TBD_RS01350	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TBD_RS01360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TBD_RS01370	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TBD_RS01385	COG1131	(ABC) transporter
TBD_RS01415	COG0489	protein tyrosine kinase activity
TBD_RS01425	COG3409	Peptidoglycan-binding domain 1 protein
TBD_RS01425	COG3267	Type II secretory pathway component ExeA
TBD_RS01455	COG0438	transferase activity, transferring glycosyl groups
TBD_RS01460	COG0367	asparagine synthase
TBD_RS01465	COG0438	transferase activity, transferring glycosyl groups
TBD_RS01470	COG0297	glycogen (starch) synthase activity
TBD_RS01505	COG1216	Glycosyl transferase, family 2
TBD_RS01510	COG0438	transferase activity, transferring glycosyl groups
TBD_RS01525	COG0438	transferase activity, transferring glycosyl groups
TBD_RS01530	COG3119	arylsulfatase activity
TBD_RS01555	COG2244	polysaccharide biosynthetic process
TBD_RS01565	COG1216	Glycosyl transferase, family 2
TBD_RS01575	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TBD_RS01580	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TBD_RS01585	COG1040	competence protein
TBD_RS01595	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TBD_RS01600	COG0156	8-amino-7-oxononanoate synthase activity
TBD_RS01605	COG2267	carboxylic ester hydrolase activity
TBD_RS01610	COG2226	methyltransferase
TBD_RS01615	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TBD_RS01630	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TBD_RS01635	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
TBD_RS01665	COG1612	heme a metabolic process
TBD_RS01670	COG0109	protoheme IX farnesyltransferase activity
TBD_RS01680	COG1999	signal sequence binding
TBD_RS01700	COG2010	Cytochrome c
TBD_RS01705	COG0348	domain, Protein
TBD_RS01720	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TBD_RS01750	COG2203	Gaf domain
TBD_RS01750	COG3706	GGDEF domain
TBD_RS01750	COG4251	negative regulation of phosphorylation
TBD_RS01750	COG5001	Diguanylate cyclase
TBD_RS01780	COG4085	toxin activity
TBD_RS01780	COG1525	nuclease
TBD_RS01780	COG0737	Belongs to the 5'-nucleotidase family
TBD_RS01785	COG0811	peptide transport
TBD_RS01835	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TBD_RS01835	COG0574	Belongs to the PEP-utilizing enzyme family
TBD_RS01850	COG2177	Part of the ABC transporter FtsEX involved in
TBD_RS01855	COG2884	Cell division ATP-binding protein ftsE
TBD_RS01865	COG0612	Peptidase, M16
TBD_RS01870	COG0612	Peptidase, M16
TBD_RS01875	COG0742	ribosomal rna small subunit methyltransferase
TBD_RS01880	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TBD_RS01885	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TBD_RS01895	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TBD_RS01905	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
TBD_RS01910	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TBD_RS01920	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TBD_RS01925	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TBD_RS01930	COG0193	aminoacyl-tRNA hydrolase activity
TBD_RS01935	COG0012	GTP binding
TBD_RS01955	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TBD_RS01965	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TBD_RS01975	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TBD_RS01980	COG0081	regulation of translation
TBD_RS01985	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TBD_RS01990	COG0222	ribosome binding
TBD_RS01995	COG0085	RNA polymerase activity
TBD_RS02000	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TBD_RS02005	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TBD_RS02010	COG0049	tRNA binding
TBD_RS02015	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TBD_RS02020	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TBD_RS02025	COG0051	transcription antitermination factor activity, RNA binding
TBD_RS02030	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TBD_RS02035	COG0088	Forms part of the polypeptide exit tunnel
TBD_RS02040	COG0089	rRNA binding
TBD_RS02045	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TBD_RS02050	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TBD_RS02055	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TBD_RS02060	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TBD_RS02065	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TBD_RS02070	COG0255	Belongs to the universal ribosomal protein uL29 family
TBD_RS02075	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TBD_RS02080	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TBD_RS02085	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TBD_RS02090	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TBD_RS02095	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TBD_RS02100	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TBD_RS02105	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TBD_RS02110	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TBD_RS02115	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TBD_RS02120	COG1841	ribosomal large subunit assembly
TBD_RS02125	COG0200	Binds to the 23S rRNA
TBD_RS02130	COG0201	protein transport
TBD_RS02135	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TBD_RS02140	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TBD_RS02145	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TBD_RS02150	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TBD_RS02155	COG0202	RNA polymerase activity
TBD_RS02160	COG0203	ribosomal protein L17
TBD_RS02180	COG1187	pseudouridine synthase activity
TBD_RS02190	COG2814	Major facilitator Superfamily
TBD_RS02195	COG0629	single-stranded DNA binding
TBD_RS02200	COG4206	TonB-dependent receptor
TBD_RS02215	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TBD_RS02225	COG0494	nUDIX hydrolase
TBD_RS02240	COG2321	neutral zinc metallopeptidase
TBD_RS02260	COG1765	OsmC-like protein
TBD_RS02270	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TBD_RS02275	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TBD_RS02280	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TBD_RS02285	COG0316	Belongs to the HesB IscA family
TBD_RS02290	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
TBD_RS02295	COG0741	lytic transglycosylase activity
TBD_RS02295	COG0739	heme binding
TBD_RS02295	COG1196	nuclear chromosome segregation
TBD_RS02300	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TBD_RS02335	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TBD_RS02345	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TBD_RS02350	COG3161	chorismate lyase activity
TBD_RS02375	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TBD_RS02385	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TBD_RS02390	COG1758	RNA polymerase activity
TBD_RS02395	COG0194	GDP metabolic process
TBD_RS02400	COG1561	YicC-like family, N-terminal region
TBD_RS02405	COG0515	serine threonine protein kinase
TBD_RS02405	COG3266	domain, Protein
TBD_RS02410	COG0631	protein serine/threonine phosphatase activity
TBD_RS02415	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TBD_RS02420	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TBD_RS02425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TBD_RS02435	COG0302	gtp cyclohydrolase
TBD_RS02450	COG2020	methyltransferase activity
TBD_RS02470	COG0084	hydrolase, TatD family'
TBD_RS02475	COG0670	Belongs to the BI1 family
TBD_RS02480	COG0330	HflC and HflK could
TBD_RS02490	COG1320	monovalent cation:proton antiporter activity
TBD_RS02495	COG2212	antiporter activity
TBD_RS02500	COG1863	multisubunit Na H antiporter MnhE subunit
TBD_RS02505	COG0651	ATP synthesis coupled electron transport
TBD_RS02510	COG1006	Multisubunit Na H antiporter MnhC subunit
TBD_RS02515	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TBD_RS02515	COG2111	Na H antiporter
TBD_RS02525	COG0668	transmembrane transport
TBD_RS02530	COG3263	regulation of cellular component size
TBD_RS02535	COG0530	calcium, potassium:sodium antiporter activity
TBD_RS02540	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TBD_RS02545	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TBD_RS02550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TBD_RS02590	COG0312	modulator of DNA gyrase
TBD_RS02600	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TBD_RS02605	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TBD_RS02610	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TBD_RS02615	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TBD_RS02625	COG3118	belongs to the thioredoxin family
TBD_RS02640	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TBD_RS02660	COG0163	prenyltransferase activity
TBD_RS02675	COG1660	Displays ATPase and GTPase activities
TBD_RS02680	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TBD_RS02685	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TBD_RS02695	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TBD_RS02705	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
TBD_RS02715	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
TBD_RS02765	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TBD_RS02795	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TBD_RS02820	COG0714	Associated with various cellular activities
TBD_RS02835	COG3256	nitric oxide reductase
TBD_RS02840	COG2010	Cytochrome c
TBD_RS02850	COG3258	Cytochrome c
TBD_RS02870	COG4783	chaperone-mediated protein folding
TBD_RS02875	COG0315	cyclic pyranopterin monophosphate synthase activity
TBD_RS02880	COG0243	molybdopterin cofactor binding
TBD_RS02885	COG0437	4 iron, 4 sulfur cluster binding
TBD_RS02890	COG3302	dmso reductase anchor subunit
TBD_RS02895	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TBD_RS02900	COG0425	Belongs to the sulfur carrier protein TusA family
TBD_RS02905	COG2210	Belongs to the sulfur carrier protein TusA family
TBD_RS02915	COG0525	valine-tRNA ligase activity
TBD_RS02930	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TBD_RS02945	COG2833	Protein of unknown function (DUF455)
TBD_RS02955	COG2850	peptidyl-arginine hydroxylation
TBD_RS02960	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TBD_RS02970	COG0825	malonyl-CoA metabolic process
TBD_RS02975	COG0037	tRNA processing
TBD_RS02980	COG0105	UTP biosynthetic process
TBD_RS02985	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TBD_RS03000	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TBD_RS03005	COG0124	histidyl-tRNA synthetase
TBD_RS03015	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TBD_RS03020	COG1160	GTP binding
TBD_RS03040	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TBD_RS03045	COG0330	HflC and HflK could
TBD_RS03050	COG0330	HflC and HflK could
TBD_RS03060	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TBD_RS03065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TBD_RS03075	COG0557	exoribonuclease II activity
TBD_RS03080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TBD_RS03095	COG1944	ATP diphosphatase activity
TBD_RS03110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TBD_RS03120	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TBD_RS03130	COG0504	CTP synthase activity
TBD_RS03135	COG2877	3-deoxy-8-phosphooctulonate synthase activity
TBD_RS03140	COG0148	phosphopyruvate hydratase activity
TBD_RS03145	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TBD_RS03155	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TBD_RS03165	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TBD_RS03165	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TBD_RS03180	COG0047	phosphoribosylformylglycinamidine synthase activity
TBD_RS03180	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TBD_RS03185	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TBD_RS03210	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TBD_RS03250	COG3278	Belongs to the heme-copper respiratory oxidase family
TBD_RS03255	COG0686	Belongs to the AlaDH PNT family
TBD_RS03265	COG0167	dihydroorotate dehydrogenase activity
TBD_RS03270	COG1301	dicarboxylic acid transport
TBD_RS03275	COG1686	Belongs to the peptidase S11 family
TBD_RS03300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TBD_RS03310	COG0022	dehydrogenase e1 component
TBD_RS03310	COG0508	dehydrogenase complex catalyzes the overall conversion of
TBD_RS03315	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TBD_RS03320	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TBD_RS03330	COG0564	pseudouridine synthase activity
TBD_RS03340	COG0840	transmembrane signaling receptor activity
TBD_RS03350	COG0028	Belongs to the TPP enzyme family
TBD_RS03355	COG1285	pathogenesis
TBD_RS03365	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TBD_RS03370	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TBD_RS03390	COG2197	response regulator
TBD_RS03405	COG0477	Major facilitator Superfamily
TBD_RS03415	COG1067	ATP-dependent peptidase activity
TBD_RS03430	COG1278	Cold shock
TBD_RS03435	COG4681	YaeQ
TBD_RS03450	COG1054	Belongs to the UPF0176 family
TBD_RS03455	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
TBD_RS03460	COG4181	ATPase activity
TBD_RS03470	COG3012	SEC-C Motif Domain Protein
TBD_RS03495	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TBD_RS03500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TBD_RS03505	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TBD_RS03515	COG1185	polyribonucleotide nucleotidyltransferase activity
TBD_RS03520	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TBD_RS03525	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TBD_RS03530	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TBD_RS03535	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TBD_RS03535	COG3064	Membrane
TBD_RS03540	COG0195	Participates in both transcription termination and antitermination
TBD_RS03540	COG2251	uridine kinase activity
TBD_RS03545	COG0779	Required for maturation of 30S ribosomal subunits
TBD_RS03570	COG0322	excinuclease ABC activity
TBD_RS03580	COG1573	uracil-dna glycosylase
TBD_RS03595	COG1730	sister chromatid segregation
TBD_RS03640	COG4774	siderophore transport
TBD_RS03650	COG0019	diaminopimelate decarboxylase activity
TBD_RS03660	COG2814	Major facilitator Superfamily
TBD_RS03675	COG4772	TonB-dependent receptor
TBD_RS03680	COG0672	)-iron permease
TBD_RS03700	COG1472	Belongs to the glycosyl hydrolase 3 family
TBD_RS03705	COG0736	holo-[acyl-carrier-protein] synthase activity
TBD_RS03715	COG2204	response regulator
TBD_RS03725	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TBD_RS03735	COG1028	Short-chain dehydrogenase reductase Sdr
TBD_RS03760	COG5265	(ABC) transporter
TBD_RS03765	COG0438	transferase activity, transferring glycosyl groups
TBD_RS03770	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TBD_RS03775	COG0859	PFAM glycosyl transferase family 9
TBD_RS03810	COG3864	Putative metallopeptidase domain
TBD_RS03815	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TBD_RS03825	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TBD_RS03835	COG2165	general secretion pathway protein
TBD_RS03890	COG3409	Peptidoglycan-binding domain 1 protein
TBD_RS03890	COG3267	Type II secretory pathway component ExeA
TBD_RS03905	COG0436	Aminotransferase
TBD_RS03920	COG1217	gtp-binding protein TYPA
TBD_RS03930	COG2346	COG2346, Truncated hemoglobins
TBD_RS03935	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
TBD_RS03945	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TBD_RS03950	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TBD_RS03960	COG0242	peptide deformylase activity
TBD_RS03975	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
TBD_RS03980	COG0024	Methionine aminopeptidase
TBD_RS03985	COG0052	Belongs to the universal ribosomal protein uS2 family
TBD_RS03990	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TBD_RS03995	COG0528	UMP kinase activity
TBD_RS04000	COG0233	cytoplasmic translational termination
TBD_RS04005	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TBD_RS04010	COG0575	Belongs to the CDS family
TBD_RS04015	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TBD_RS04035	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TBD_RS04040	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TBD_RS04045	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TBD_RS04050	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TBD_RS04055	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TBD_RS04085	COG0045	succinate-CoA ligase (ADP-forming) activity
TBD_RS04090	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TBD_RS04095	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TBD_RS04095	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TBD_RS04110	COG0564	pseudouridine synthase activity
TBD_RS04125	COG0454	-acetyltransferase
TBD_RS04125	COG0456	acetyltransferase
TBD_RS04135	COG0542	response to heat
TBD_RS04155	COG4944	Protein of unknown function (DUF1109)
TBD_RS04165	COG2010	Cytochrome c
TBD_RS04175	COG0714	Associated with various cellular activities
TBD_RS04195	COG0587	DNA-directed DNA polymerase activity
TBD_RS04210	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
TBD_RS04215	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TBD_RS04230	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TBD_RS04235	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TBD_RS04240	COG4942	peptidase
TBD_RS04240	COG1388	LysM domain
TBD_RS04245	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TBD_RS04250	COG1011	Hydrolase
TBD_RS04265	COG0436	Aminotransferase
TBD_RS04280	COG1573	uracil-dna glycosylase
TBD_RS04285	COG0625	glutathione transferase activity
TBD_RS04290	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TBD_RS04305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TBD_RS04310	COG0482	sulfurtransferase activity
TBD_RS04330	COG1278	Cold shock
TBD_RS04340	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TBD_RS04350	COG1254	Belongs to the acylphosphatase family
TBD_RS04355	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TBD_RS04355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TBD_RS04375	COG0142	geranyltranstransferase activity
TBD_RS04380	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TBD_RS04385	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TBD_RS04390	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TBD_RS04430	COG2046	Belongs to the sulfate adenylyltransferase family
TBD_RS04440	COG0505	Belongs to the CarA family
TBD_RS04445	COG3577	Aspartyl protease
TBD_RS04450	COG1469	GTP cyclohydrolase I activity
TBD_RS04455	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TBD_RS04460	COG0142	geranyltranstransferase activity
TBD_RS04465	COG1722	exodeoxyribonuclease VII activity
TBD_RS04515	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TBD_RS04525	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TBD_RS04540	COG0514	ATP-dependent DNA helicase (RecQ)
TBD_RS04555	COG0308	aminopeptidase N
TBD_RS04575	COG3852	Histidine kinase
TBD_RS04590	COG2032	superoxide dismutase activity
TBD_RS04670	COG3174	membrane
TBD_RS04680	COG1028	Short-chain dehydrogenase reductase Sdr
TBD_RS04715	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TBD_RS04730	COG2189	Belongs to the N(4) N(6)-methyltransferase family
TBD_RS04745	COG0582	viral genome integration into host DNA
TBD_RS04760	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TBD_RS04765	COG0402	S-adenosylhomocysteine deaminase activity
TBD_RS04775	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TBD_RS04780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TBD_RS04790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TBD_RS04795	COG0287	Prephenate dehydrogenase
TBD_RS04800	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TBD_RS04805	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TBD_RS04815	COG0776	regulation of translation
TBD_RS04825	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
TBD_RS04830	COG0284	orotidine-5'-phosphate decarboxylase activity
TBD_RS04840	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TBD_RS04845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TBD_RS04870	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TBD_RS04890	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TBD_RS04910	COG0166	Belongs to the GPI family
TBD_RS04915	COG1047	Peptidyl-prolyl cis-trans
TBD_RS04950	COG0501	Belongs to the peptidase M48B family
TBD_RS04960	COG1234	tRNA 3'-trailer cleavage
TBD_RS04975	COG4999	Histidine kinase
TBD_RS04975	COG3850	Histidine kinase
TBD_RS04975	COG2205	protein histidine kinase activity
TBD_RS04975	COG3437	response regulator, receiver
TBD_RS05000	COG0791	NLP P60 protein
TBD_RS05015	COG5002	protein histidine kinase activity
TBD_RS05015	COG5001	Diguanylate cyclase
TBD_RS05025	COG1199	ATP-dependent helicase activity
TBD_RS05030	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TBD_RS05035	COG2840	Smr protein MutS2
TBD_RS05040	COG0492	ferredoxin-NADP+ reductase activity
TBD_RS05045	COG1674	ftsk spoiiie
TBD_RS05050	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TBD_RS05055	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TBD_RS05075	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TBD_RS05080	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TBD_RS05085	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TBD_RS05090	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TBD_RS05095	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TBD_RS05100	COG0072	phenylalanine-tRNA ligase activity
TBD_RS05100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TBD_RS05105	COG0776	regulation of translation
TBD_RS05120	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TBD_RS05140	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
TBD_RS05145	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
TBD_RS05160	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TBD_RS05165	COG1763	Mo-molybdopterin cofactor biosynthetic process
TBD_RS05180	COG0314	molybdopterin synthase activity
TBD_RS05190	COG3038	cytochrome b561
TBD_RS05210	COG0826	peptidase U32
TBD_RS05225	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TBD_RS05265	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TBD_RS05270	COG0700	Nucleoside recognition
TBD_RS05275	COG0248	Ppx GppA phosphatase
TBD_RS05280	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TBD_RS05300	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TBD_RS05325	COG2259	Doxx family
TBD_RS05340	COG2226	methyltransferase
TBD_RS05350	COG2203	Gaf domain
TBD_RS05350	COG2200	EAL domain
TBD_RS05350	COG2199	diguanylate cyclase activity
TBD_RS05395	COG2132	Multicopper oxidase
TBD_RS05410	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TBD_RS05425	COG0326	Molecular chaperone. Has ATPase activity
TBD_RS05445	COG0842	Transport permease protein
TBD_RS05450	COG1131	(ABC) transporter
TBD_RS05470	COG2062	phosphohistidine phosphatase, SixA
TBD_RS05480	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TBD_RS05490	COG1157	protein secretion by the type III secretion system
TBD_RS05515	COG1987	bacterial-type flagellum assembly
TBD_RS05525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TBD_RS05530	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
TBD_RS05535	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TBD_RS05540	COG0513	Belongs to the DEAD box helicase family
TBD_RS05550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TBD_RS05555	COG1017	nitric oxide dioxygenase activity
TBD_RS05555	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TBD_RS05560	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TBD_RS05570	COG0247	lactate metabolic process
TBD_RS05580	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TBD_RS05595	COG1741	Belongs to the pirin family
TBD_RS05605	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TBD_RS05615	COG0583	DNA-binding transcription factor activity
TBD_RS05620	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TBD_RS05635	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TBD_RS05640	COG0406	alpha-ribazole phosphatase activity
TBD_RS05645	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TBD_RS05650	COG0735	belongs to the Fur family
TBD_RS05655	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TBD_RS05660	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TBD_RS05670	COG0505	Belongs to the CarA family
TBD_RS05675	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TBD_RS05680	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TBD_RS05690	COG1534	Rna-binding protein
TBD_RS05695	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TBD_RS05700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TBD_RS05705	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TBD_RS05710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TBD_RS05715	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TBD_RS05720	COG0573	inorganic phosphate transmembrane transporter activity
TBD_RS05725	COG0581	inorganic phosphate transmembrane transporter activity
TBD_RS05730	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TBD_RS05735	COG0149	triose-phosphate isomerase activity
TBD_RS05750	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TBD_RS05755	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TBD_RS05760	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TBD_RS05765	COG0649	NAD binding
TBD_RS05770	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TBD_RS05780	COG1034	ATP synthesis coupled electron transport
TBD_RS05785	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TBD_RS05790	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TBD_RS05800	COG0713	ATP synthesis coupled electron transport
TBD_RS05815	COG1007	ATP synthesis coupled electron transport
TBD_RS05835	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TBD_RS05840	COG0483	inositol monophosphate 1-phosphatase activity
TBD_RS05860	COG1104	cysteine desulfurase activity
TBD_RS05865	COG0822	iron-sulfur transferase activity
TBD_RS05870	COG0316	Belongs to the HesB IscA family
TBD_RS05880	COG0443	Heat shock 70 kDa protein
TBD_RS05905	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TBD_RS05910	COG1640	4-alpha-glucanotransferase
TBD_RS05915	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TBD_RS05945	COG0281	malic enzyme
TBD_RS05955	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
TBD_RS05960	COG1053	succinate dehydrogenase
TBD_RS05965	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TBD_RS05980	COG0567	Dehydrogenase, E1 component
TBD_RS05985	COG0508	dehydrogenase complex catalyzes the overall conversion of
TBD_RS05990	COG1127	ABC transporter
TBD_RS06000	COG0784	Response regulator, receiver
TBD_RS06005	COG4191	Histidine kinase
TBD_RS06015	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TBD_RS06040	COG0667	Aldo Keto reductase
TBD_RS06125	COG2171	N-acyltransferase activity
TBD_RS06135	COG0697	spore germination
TBD_RS06155	COG1070	Carbohydrate kinase
TBD_RS06160	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TBD_RS06170	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TBD_RS06175	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
TBD_RS06185	COG2766	serine protein kinase
TBD_RS06190	COG2718	Belongs to the UPF0229 family
TBD_RS06195	COG2719	SpoVR family
TBD_RS06200	COG0723	plastoquinol--plastocyanin reductase activity
TBD_RS06205	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TBD_RS06210	COG0542	response to heat
TBD_RS06245	COG1360	Flagellar Motor Protein
TBD_RS06255	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TBD_RS06265	COG0489	protein tyrosine kinase activity
TBD_RS06270	COG1191	sigma factor activity
TBD_RS06275	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TBD_RS06285	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TBD_RS06290	COG2210	Belongs to the sulfur carrier protein TusA family
TBD_RS06295	COG0425	Belongs to the sulfur carrier protein TusA family
TBD_RS06310	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TBD_RS06355	COG4206	TonB-dependent receptor
TBD_RS06365	COG5002	protein histidine kinase activity
TBD_RS06365	COG2205	protein histidine kinase activity
TBD_RS06365	COG0784	Response regulator, receiver
TBD_RS06380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TBD_RS06390	COG5265	(ABC) transporter
TBD_RS06405	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
TBD_RS06425	COG1104	cysteine desulfurase activity
TBD_RS06430	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TBD_RS06435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TBD_RS06435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TBD_RS06450	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TBD_RS06475	COG2197	response regulator
TBD_RS06485	COG0737	Belongs to the 5'-nucleotidase family
TBD_RS06500	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TBD_RS06525	COG1450	Type ii and iii secretion system protein
TBD_RS06545	COG3459	Glycosyltransferase 36 associated
TBD_RS06550	COG2267	carboxylic ester hydrolase activity
TBD_RS06570	COG2221	Nitrite and sulphite reductase 4Fe-4S
TBD_RS06575	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
TBD_RS06580	COG2943	transferase activity, transferring hexosyl groups
TBD_RS06625	COG2132	Multicopper oxidase
TBD_RS06665	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TBD_RS06670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TBD_RS06695	COG2608	mercury ion transmembrane transporter activity
TBD_RS06765	COG1538	Outer membrane efflux protein
TBD_RS06780	COG0577	efflux transmembrane transporter activity
TBD_RS06780	COG1136	(ABC) transporter
TBD_RS06790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TBD_RS06800	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TBD_RS06830	COG2221	Nitrite and sulphite reductase 4Fe-4S
TBD_RS06835	COG0071	Belongs to the small heat shock protein (HSP20) family
TBD_RS06860	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
TBD_RS06885	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
TBD_RS06890	COG0298	carbon dioxide binding
TBD_RS06895	COG0375	protein maturation
TBD_RS06905	COG0409	Hydrogenase expression formation protein
TBD_RS06910	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TBD_RS06915	COG0309	Hydrogenase expression formation protein (HypE)
TBD_RS06930	COG4263	nitrous-oxide reductase activity
TBD_RS06980	COG2197	response regulator
TBD_RS06985	COG3850	Histidine kinase
TBD_RS06995	COG2223	nitrite transmembrane transporter activity
TBD_RS07000	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
TBD_RS07005	COG1140	nitrate reductase beta subunit
TBD_RS07010	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
TBD_RS07015	COG2181	nitrate reductase activity
TBD_RS07020	COG0446	pyridine nucleotide-disulphide oxidoreductase
TBD_RS07025	COG2920	part of a sulfur-relay system
TBD_RS07035	COG0405	Gamma-glutamyltransferase
TBD_RS07045	COG1136	(ABC) transporter
TBD_RS07045	COG0577	efflux transmembrane transporter activity
TBD_RS07050	COG1136	(ABC) transporter
TBD_RS07050	COG0577	efflux transmembrane transporter activity
TBD_RS07070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TBD_RS07075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TBD_RS07085	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TBD_RS07110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TBD_RS07115	COG0798	PFAM Bile acid sodium symporter
TBD_RS07130	COG2226	methyltransferase
TBD_RS07150	COG2165	general secretion pathway protein
TBD_RS07155	COG1459	type II secretion system
TBD_RS07220	COG1796	DNA polymerase
TBD_RS07220	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TBD_RS07250	COG1181	Belongs to the D-alanine--D-alanine ligase family
TBD_RS07295	COG0668	transmembrane transport
TBD_RS07300	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TBD_RS07310	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TBD_RS07330	COG0300	oxidoreductase activity
TBD_RS07340	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TBD_RS07355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TBD_RS07360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TBD_RS07390	COG1573	uracil-dna glycosylase
TBD_RS07395	COG1183	phosphatidylcholine synthase activity
TBD_RS07400	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TBD_RS07455	COG5654	RES domain protein
TBD_RS07460	COG5642	Protein of unknown function (DUF2384)
TBD_RS07470	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TBD_RS07475	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TBD_RS07490	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TBD_RS07500	COG0205	6-phosphofructokinase activity
TBD_RS07510	COG0563	adenylate kinase activity
TBD_RS07515	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TBD_RS07530	COG1663	tetraacyldisaccharide 4'-kinase activity
TBD_RS07535	COG0848	biopolymer transport protein
TBD_RS07540	COG0811	peptide transport
TBD_RS07545	COG1570	exodeoxyribonuclease VII activity
TBD_RS07550	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TBD_RS07555	COG3588	fructose-bisphosphate aldolase
TBD_RS07575	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TBD_RS07585	COG0860	N-Acetylmuramoyl-L-alanine amidase
TBD_RS07605	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TBD_RS07620	COG0180	Tryptophanyl-tRNA synthetase
TBD_RS07625	COG1994	Peptidase M50
TBD_RS07630	COG0009	L-threonylcarbamoyladenylate synthase
TBD_RS07635	COG0613	PHP domain protein
TBD_RS07640	COG2917	probably involved in intracellular septation
TBD_RS07645	COG2350	Protein conserved in bacteria
TBD_RS07650	COG0271	Belongs to the BolA IbaG family
TBD_RS07655	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TBD_RS07660	COG1923	regulation of RNA biosynthetic process
TBD_RS07665	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TBD_RS07675	COG0463	Glycosyl transferase, family 2
TBD_RS07685	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TBD_RS07690	COG0443	Heat shock 70 kDa protein
TBD_RS07695	COG0484	heat shock protein binding
TBD_RS07700	COG0084	hydrolase, TatD family'
TBD_RS07715	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TBD_RS07720	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TBD_RS07725	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TBD_RS07730	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TBD_RS07735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TBD_RS07740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TBD_RS07745	COG1028	Short-chain dehydrogenase reductase Sdr
TBD_RS07755	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TBD_RS07760	COG0416	fatty acid biosynthetic process
TBD_RS07765	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TBD_RS07770	COG1399	metal-binding, possibly nucleic acid-binding protein
TBD_RS07775	COG0439	Biotin carboxylase
TBD_RS07780	COG0511	ligase activity, forming carbon-carbon bonds
TBD_RS07780	COG5016	pyruvate
TBD_RS07785	COG0424	maF-like protein
TBD_RS07790	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TBD_RS07810	COG0546	phosphoglycolate phosphatase activity
TBD_RS07820	COG1530	ribonuclease E activity
TBD_RS07825	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TBD_RS07835	COG0556	nucleotide-excision repair
TBD_RS07840	COG0436	Aminotransferase
TBD_RS07855	COG0582	viral genome integration into host DNA
TBD_RS07880	COG0537	adenosine 5'-monophosphoramidase activity
TBD_RS07885	COG1902	pentaerythritol trinitrate reductase activity
TBD_RS07890	COG2814	Major facilitator Superfamily
TBD_RS07915	COG1136	(ABC) transporter
TBD_RS07915	COG0577	efflux transmembrane transporter activity
TBD_RS07930	COG1355	regulation of microtubule-based process
TBD_RS07940	COG2197	response regulator
TBD_RS07960	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TBD_RS07980	COG2257	FlhB HrpN YscU SpaS Family
TBD_RS07985	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
TBD_RS07990	COG0784	Response regulator, receiver
TBD_RS07990	COG0835	chemotaxis
TBD_RS07995	COG1677	Flagellar hook-basal body complex protein FliE
TBD_RS08000	COG1766	The M ring may be actively involved in energy transduction
TBD_RS08015	COG1157	protein secretion by the type III secretion system
TBD_RS08040	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TBD_RS08045	COG3190	flagellar
TBD_RS08055	COG1987	bacterial-type flagellum assembly
TBD_RS08065	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
TBD_RS08070	COG0745	RESPONSE REGULATOR receiver
TBD_RS08075	COG2201	protein-glutamate methylesterase activity
TBD_RS08080	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TBD_RS08085	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TBD_RS08090	COG0840	transmembrane signaling receptor activity
TBD_RS08095	COG0840	transmembrane signaling receptor activity
TBD_RS08100	COG0840	transmembrane signaling receptor activity
TBD_RS08105	COG0737	Belongs to the 5'-nucleotidase family
TBD_RS08110	COG0840	transmembrane signaling receptor activity
TBD_RS08125	COG0745	RESPONSE REGULATOR receiver
TBD_RS08135	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TBD_RS08150	COG1706	bacterial-type flagellum-dependent cell motility
TBD_RS08155	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TBD_RS08165	COG4787	bacterial-type flagellum-dependent cell motility
TBD_RS08175	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TBD_RS08180	COG1558	bacterial-type flagellum-dependent cell motility
TBD_RS08195	COG2747	anti-sigma28 factor FlgM
TBD_RS08205	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TBD_RS08205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TBD_RS08215	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TBD_RS08225	COG2048	Heterodisulfide reductase, subunit B
TBD_RS08230	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TBD_RS08235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TBD_RS08235	COG0723	plastoquinol--plastocyanin reductase activity
TBD_RS08240	COG1233	COG1233 Phytoene dehydrogenase and related
TBD_RS08260	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TBD_RS08280	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TBD_RS08300	COG5001	Diguanylate cyclase
TBD_RS08300	COG5002	protein histidine kinase activity
TBD_RS08315	COG0328	RNA-DNA hybrid ribonuclease activity
TBD_RS08325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TBD_RS08330	COG0741	lytic transglycosylase activity
TBD_RS08330	COG1388	LysM domain
TBD_RS08340	COG4172	Belongs to the ABC transporter superfamily
TBD_RS08345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TBD_RS08350	COG0601	transmembrane transport
TBD_RS08365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TBD_RS08385	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TBD_RS08390	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TBD_RS08395	COG0740	serine-type endopeptidase activity
TBD_RS08400	COG0544	peptidyl-prolyl cis-trans isomerase activity
TBD_RS08470	COG0464	growth
TBD_RS08485	COG1562	ergosterol biosynthetic process
TBD_RS08495	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TBD_RS08500	COG1028	Short-chain dehydrogenase reductase Sdr
TBD_RS08505	COG2815	serine threonine protein kinase
TBD_RS08505	COG0515	serine threonine protein kinase
TBD_RS08510	COG0004	ammonium transporteR
TBD_RS08520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TBD_RS08525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TBD_RS08535	COG0140	phosphoribosyl-ATP diphosphatase activity
TBD_RS08540	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TBD_RS08545	COG0107	imidazoleglycerol-phosphate synthase activity
TBD_RS08550	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TBD_RS08555	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TBD_RS08560	COG0131	Imidazoleglycerol-phosphate dehydratase
TBD_RS08565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TBD_RS08570	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TBD_RS08590	COG0583	DNA-binding transcription factor activity
TBD_RS08605	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
TBD_RS08610	COG1704	LemA family
TBD_RS08615	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TBD_RS08620	COG1573	uracil-dna glycosylase
TBD_RS08625	COG0456	acetyltransferase
TBD_RS08630	COG1214	PFAM Peptidase M22, glycoprotease
TBD_RS08645	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TBD_RS08665	COG4797	methyltransferase
TBD_RS08665	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TBD_RS08670	COG0513	Belongs to the DEAD box helicase family
TBD_RS08680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TBD_RS08690	COG0589	response to stress
TBD_RS08700	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TBD_RS08705	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TBD_RS08705	COG0493	'glutamate synthase
TBD_RS08725	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TBD_RS08730	COG4566	intracellular signal transduction
TBD_RS08735	COG4191	Histidine kinase
TBD_RS08765	COG5002	protein histidine kinase activity
TBD_RS08770	COG0519	Catalyzes the synthesis of GMP from XMP
TBD_RS08770	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TBD_RS08785	COG2914	Belongs to the UPF0125 (RnfH) family
TBD_RS08790	COG2867	negative regulation of translational initiation
TBD_RS08795	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TBD_RS08800	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
TBD_RS08805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TBD_RS08815	COG1136	(ABC) transporter
TBD_RS08825	COG0432	Pfam Uncharacterised protein family UPF0047
TBD_RS08835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TBD_RS08885	COG1454	alcohol dehydrogenase
TBD_RS08900	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TBD_RS08900	COG0543	2 iron, 2 sulfur cluster binding
TBD_RS08915	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TBD_RS08920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TBD_RS08925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TBD_RS08970	COG0297	glycogen (starch) synthase activity
TBD_RS09010	COG0489	protein tyrosine kinase activity
TBD_RS09050	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TBD_RS09170	COG2969	positive regulation of protein catabolic process
TBD_RS09175	COG0625	glutathione transferase activity
TBD_RS09180	COG2857	Cytochrome c1
TBD_RS09185	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TBD_RS09190	COG0723	plastoquinol--plastocyanin reductase activity
TBD_RS09195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TBD_RS09220	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
TBD_RS09230	COG2154	pterin-4-alpha-carbinolamine dehydratase
TBD_RS09235	COG1162	GTPase activity
TBD_RS09250	COG0693	protein deglycase activity
TBD_RS09255	COG1666	GTP binding
TBD_RS09265	COG3123	guanosine phosphorylase activity
TBD_RS09270	COG0137	argininosuccinate synthase activity
TBD_RS09280	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TBD_RS09285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TBD_RS09300	COG0268	Binds directly to 16S ribosomal RNA
TBD_RS09305	COG0728	peptidoglycan biosynthetic process
TBD_RS09310	COG0196	riboflavin kinase activity
TBD_RS09315	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TBD_RS09320	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TBD_RS09325	COG1047	Peptidyl-prolyl cis-trans
TBD_RS09330	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TBD_RS09355	COG4968	Prepilin-type N-terminal cleavage methylation domain
TBD_RS09370	COG0438	transferase activity, transferring glycosyl groups
TBD_RS09390	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TBD_RS09405	COG1442	glycosyl transferase family 8
TBD_RS09405	COG1216	Glycosyl transferase, family 2
TBD_RS09435	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TBD_RS09455	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TBD_RS09460	COG1028	Short-chain dehydrogenase reductase Sdr
TBD_RS09480	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TBD_RS09485	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TBD_RS09490	COG0271	Belongs to the BolA IbaG family
TBD_RS09495	COG0842	Transport permease protein
TBD_RS09500	COG1131	(ABC) transporter
TBD_RS09520	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TBD_RS09525	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TBD_RS09530	COG1127	ABC transporter
TBD_RS09540	COG0215	cysteine-tRNA ligase activity
TBD_RS09585	COG0285	dihydrofolate synthase activity
TBD_RS09590	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TBD_RS09595	COG0159	tryptophan synthase activity
TBD_RS09600	COG0133	tryptophan synthase activity
TBD_RS09605	COG0135	phosphoribosylanthranilate isomerase activity
TBD_RS09610	COG0101	tRNA pseudouridine synthase activity
TBD_RS09630	COG0473	3-isopropylmalate dehydrogenase activity
TBD_RS09635	COG0066	3-isopropylmalate dehydratase activity
TBD_RS09640	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TBD_RS09645	COG2814	Major facilitator Superfamily
TBD_RS09650	COG2832	Protein of unknown function (DUF454)
TBD_RS09655	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TBD_RS09695	COG0702	epimerase
TBD_RS09715	COG5001	Diguanylate cyclase
TBD_RS09715	COG5002	protein histidine kinase activity
TBD_RS09735	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
TBD_RS09745	COG2116	formate transmembrane transporter activity
TBD_RS09750	COG2183	response to ionizing radiation
TBD_RS09765	COG1017	nitric oxide dioxygenase activity
TBD_RS09765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TBD_RS09780	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TBD_RS09790	COG3706	GGDEF domain
TBD_RS09800	COG3954	Phosphoribulokinase
TBD_RS09830	COG2353	YceI-like domain
TBD_RS09885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TBD_RS09900	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TBD_RS09905	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TBD_RS09905	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TBD_RS09910	COG0788	formyltetrahydrofolate deformylase activity
TBD_RS09930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TBD_RS09940	COG0425	Belongs to the sulfur carrier protein TusA family
TBD_RS09950	COG1309	transcriptional regulator
TBD_RS09955	COG0697	spore germination
TBD_RS09960	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TBD_RS09965	COG1183	phosphatidylcholine synthase activity
TBD_RS09970	COG0688	phosphatidylethanolamine metabolic process
TBD_RS09975	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TBD_RS09980	COG0440	acetolactate synthase activity
TBD_RS09985	COG0028	Belongs to the TPP enzyme family
TBD_RS10020	COG0277	FAD linked oxidase domain protein
TBD_RS10060	COG0582	viral genome integration into host DNA
TBD_RS10070	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TBD_RS10075	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TBD_RS10080	COG1643	Atp-dependent helicase
TBD_RS10110	COG1959	2 iron, 2 sulfur cluster binding
TBD_RS10115	COG4657	Part of a membrane complex involved in electron transport
TBD_RS10120	COG2878	Part of a membrane complex involved in electron transport
TBD_RS10140	COG4660	Part of a membrane complex involved in electron transport
TBD_RS10145	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TBD_RS10160	COG1042	CoA-binding domain protein
TBD_RS10160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TBD_RS10160	COG0045	succinate-CoA ligase (ADP-forming) activity
TBD_RS10165	COG0123	including yeast histone deacetylase and acetoin utilization protein
TBD_RS10185	COG1525	nuclease
TBD_RS10195	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TBD_RS10200	COG1420	regulation of RNA biosynthetic process
TBD_RS10205	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TBD_RS10215	COG0446	pyridine nucleotide-disulphide oxidoreductase
TBD_RS10220	COG0589	response to stress
TBD_RS10240	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
TBD_RS10250	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
TBD_RS10255	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
TBD_RS10260	COG2217	Heavy metal translocating P-type atpase
TBD_RS10285	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TBD_RS10295	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TBD_RS10300	COG1428	Deoxynucleoside kinase
TBD_RS10305	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TBD_RS10310	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TBD_RS10315	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TBD_RS10320	COG0058	SHG alpha-glucan phosphorylase activity
TBD_RS10325	COG0297	glycogen (starch) synthase activity
TBD_RS10330	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TBD_RS10345	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TBD_RS10350	COG0837	glucose binding
TBD_RS10355	COG0166	Belongs to the GPI family
TBD_RS10360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TBD_RS10365	COG3158	transport of potassium into the cell
TBD_RS10405	COG0582	viral genome integration into host DNA
TBD_RS10415	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TBD_RS10420	COG0343	queuine tRNA-ribosyltransferase activity
TBD_RS10430	COG0501	Belongs to the peptidase M48B family
TBD_RS10435	COG1862	Preprotein translocase
TBD_RS10440	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TBD_RS10445	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TBD_RS10450	COG0586	Pfam SNARE associated Golgi protein
TBD_RS10460	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TBD_RS10465	COG1381	Involved in DNA repair and RecF pathway recombination
TBD_RS10470	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TBD_RS10475	COG0571	ribonuclease III activity
TBD_RS10485	COG0681	Belongs to the peptidase S26 family
TBD_RS10490	COG0481	GTPase activity
TBD_RS10500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TBD_RS10525	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TBD_RS10530	COG0354	folic acid binding
TBD_RS10540	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TBD_RS10550	COG0359	binds to the 23S rRNA
TBD_RS10555	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TBD_RS10565	COG0360	Binds together with S18 to 16S ribosomal RNA
TBD_RS10575	COG0717	Belongs to the dCTP deaminase family
TBD_RS10580	COG0489	protein tyrosine kinase activity
TBD_RS10590	COG0494	nUDIX hydrolase
TBD_RS10595	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TBD_RS10600	COG0442	prolyl-tRNA aminoacylation
TBD_RS10605	COG0741	lytic transglycosylase activity
TBD_RS10635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TBD_RS10650	COG0363	glucosamine-6-phosphate deaminase activity
TBD_RS10655	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TBD_RS10660	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TBD_RS10665	COG2095	MarC family integral membrane protein
TBD_RS10670	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TBD_RS10675	COG2022	thiamine diphosphate biosynthetic process
TBD_RS10695	COG1194	a g-specific adenine glycosylase
TBD_RS10730	COG0429	hydrolase of the alpha beta-hydrolase fold
TBD_RS10740	COG0438	transferase activity, transferring glycosyl groups
TBD_RS10745	COG0598	Magnesium transport protein CorA
TBD_RS10760	COG0521	Mo-molybdopterin cofactor biosynthetic process
TBD_RS10780	COG3028	Belongs to the UPF0307 family
TBD_RS10785	COG0312	modulator of DNA gyrase
TBD_RS10800	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TBD_RS10810	COG1032	radical SAM domain protein
TBD_RS10830	COG2010	Cytochrome c
TBD_RS10840	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
TBD_RS10855	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
TBD_RS10860	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TBD_RS10865	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TBD_RS10870	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TBD_RS10875	COG3338	carbonate dehydratase activity
TBD_RS10880	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TBD_RS10880	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TBD_RS10900	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TBD_RS10900	COG1328	CTP reductase activity
TBD_RS10960	COG3154	lipid carrier protein
TBD_RS10965	COG0720	synthase
TBD_RS10970	COG0826	peptidase U32
TBD_RS10975	COG0826	peptidase U32
TBD_RS10980	COG1242	4 iron, 4 sulfur cluster binding
TBD_RS10985	COG2070	2-Nitropropane dioxygenase
TBD_RS11000	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TBD_RS11005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TBD_RS11015	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TBD_RS11030	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TBD_RS11035	COG2137	regulation of response to DNA damage stimulus
TBD_RS11055	COG2391	methyltransferase activity
TBD_RS11060	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TBD_RS11065	COG0602	queuosine metabolic process
TBD_RS11070	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
TBD_RS11080	COG0823	Involved in the tonB-independent uptake of proteins
TBD_RS11100	COG0824	Thioesterase
TBD_RS11105	COG2255	four-way junction helicase activity
TBD_RS11115	COG0632	four-way junction helicase activity
TBD_RS11120	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TBD_RS11125	COG0217	transcriptional regulatory protein
TBD_RS11130	COG1940	carbohydrate kinase activity
TBD_RS11140	COG2268	Band 7 protein
TBD_RS11145	COG1585	Membrane protein implicated in regulation of membrane protease activity
TBD_RS11150	COG1252	NADH dehydrogenase
TBD_RS11155	COG0433	COG0433 Predicted ATPase
TBD_RS11160	COG0134	indole-3-glycerol-phosphate synthase activity
TBD_RS11165	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TBD_RS11175	COG0446	pyridine nucleotide-disulphide oxidoreductase
TBD_RS11185	COG2204	response regulator
TBD_RS11195	COG0546	phosphoglycolate phosphatase activity
TBD_RS11205	COG2967	ApaG domain
TBD_RS11210	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
TBD_RS11225	COG4585	Histidine kinase
TBD_RS11230	COG3279	Response regulator of the LytR AlgR family
TBD_RS11235	COG2197	response regulator
TBD_RS11265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TBD_RS11315	COG0628	permease
TBD_RS11320	COG2982	Protein involved in outer membrane biogenesis
TBD_RS11330	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TBD_RS11340	COG0673	inositol 2-dehydrogenase activity
TBD_RS11375	COG2217	Heavy metal translocating P-type atpase
TBD_RS11380	COG0789	Transcriptional regulator
TBD_RS11400	COG3707	response regulator
TBD_RS11405	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TBD_RS11410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TBD_RS11415	COG1116	anion transmembrane transporter activity
TBD_RS11445	COG1047	Peptidyl-prolyl cis-trans
TBD_RS11470	COG0583	DNA-binding transcription factor activity
TBD_RS11475	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TBD_RS11485	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TBD_RS11490	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
TBD_RS11495	COG3454	Phosphonate metabolism
TBD_RS11500	COG4778	phosphonate C-P lyase system protein PhnL
TBD_RS11505	COG4107	phosphonate C-P lyase system protein PhnK
TBD_RS11510	COG3627	carbon phosphorus lyase activity
TBD_RS11530	COG3639	organic phosphonate transmembrane transporter activity
TBD_RS11540	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TBD_RS11550	COG2188	Transcriptional regulator
TBD_RS11555	COG0850	regulation of cytokinetic process
TBD_RS11565	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TBD_RS11585	COG2146	nitrite reductase [NAD(P)H] activity
TBD_RS11590	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TBD_RS11595	COG0243	molybdopterin cofactor binding
TBD_RS11600	COG0753	catalase activity
TBD_RS11605	COG0071	Belongs to the small heat shock protein (HSP20) family
TBD_RS11610	COG1253	flavin adenine dinucleotide binding
TBD_RS11615	COG0720	synthase
TBD_RS11620	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TBD_RS11625	COG1773	rubredoxin
TBD_RS11630	COG1592	Rubrerythrin
TBD_RS11635	COG1238	metal cluster binding
TBD_RS11640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TBD_RS11645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TBD_RS11660	COG0583	DNA-binding transcription factor activity
TBD_RS11680	COG2920	part of a sulfur-relay system
TBD_RS11685	COG0583	DNA-binding transcription factor activity
TBD_RS11690	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TBD_RS11690	COG1017	nitric oxide dioxygenase activity
TBD_RS11700	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TBD_RS11705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TBD_RS11710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TBD_RS11715	COG0006	proline dipeptidase activity
TBD_RS11720	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TBD_RS11730	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
TBD_RS11735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TBD_RS11740	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TBD_RS11745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TBD_RS11750	COG3047	cAMP biosynthetic process
TBD_RS11750	COG2885	chlorophyll binding
TBD_RS11775	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TBD_RS11780	COG0751	glycine-tRNA ligase activity
TBD_RS11785	COG0752	glycyl-tRNA synthetase alpha subunit
TBD_RS11790	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TBD_RS11800	COG0488	(ABC) transporter
TBD_RS11840	COG0617	tRNA 3'-terminal CCA addition
TBD_RS11855	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TBD_RS11860	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TBD_RS11865	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
TBD_RS11870	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
TBD_RS11875	COG0237	dephospho-CoA kinase activity
TBD_RS11895	COG4536	flavin adenine dinucleotide binding
TBD_RS11900	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TBD_RS11905	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TBD_RS11910	COG0228	four-way junction DNA binding
TBD_RS11915	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TBD_RS11920	COG0336	Belongs to the RNA methyltransferase TrmD family
TBD_RS11925	COG0335	large ribosomal subunit rRNA binding
TBD_RS11955	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TBD_RS11965	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TBD_RS11970	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TBD_RS11985	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TBD_RS12000	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TBD_RS12010	COG0793	Belongs to the peptidase S41A family
TBD_RS12015	COG4942	peptidase
TBD_RS12020	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TBD_RS12025	COG0640	Transcriptional regulator
TBD_RS12035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TBD_RS12045	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TBD_RS12060	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
TBD_RS12070	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TBD_RS12075	COG0840	transmembrane signaling receptor activity
TBD_RS12080	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TBD_RS12090	COG0189	ligase activity
TBD_RS12110	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TBD_RS12115	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TBD_RS12120	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
TBD_RS12170	COG1981	membrane
TBD_RS12180	COG2900	Belongs to the SlyX family
TBD_RS12195	COG0488	(ABC) transporter
TBD_RS12210	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TBD_RS12215	COG0339	signal peptide processing
TBD_RS12235	COG1530	ribonuclease E activity
TBD_RS12240	COG0424	maF-like protein
TBD_RS12245	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TBD_RS12250	COG0799	negative regulation of ribosome biogenesis
TBD_RS12255	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TBD_RS12260	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TBD_RS12275	COG0495	leucyl-tRNA aminoacylation
TBD_RS12295	COG0210	DNA helicase
TBD_RS12320	COG3047	cAMP biosynthetic process
TBD_RS12320	COG2885	chlorophyll binding
TBD_RS12325	COG1970	mechanosensitive ion channel activity
TBD_RS12335	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
TBD_RS12340	COG0138	bifunctional purine biosynthesis protein purh
TBD_RS12345	COG0151	Belongs to the GarS family
TBD_RS12350	COG0009	L-threonylcarbamoyladenylate synthase
TBD_RS12355	COG0408	coproporphyrinogen oxidase activity
TBD_RS12365	COG3850	Histidine kinase
TBD_RS12370	COG2197	response regulator
TBD_RS12390	COG1013	pyruvate-flavodoxin oxidoreductase activity
TBD_RS12390	COG0674	pyruvate-flavodoxin oxidoreductase activity
TBD_RS12390	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TBD_RS12390	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TBD_RS12395	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TBD_RS12395	COG4651	solute:proton antiporter activity
TBD_RS12405	COG1648	precorrin-2 dehydrogenase activity
TBD_RS12405	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TBD_RS12415	COG1797	cobyrinic acid a,c-diamide synthase activity
TBD_RS12450	COG2920	part of a sulfur-relay system
TBD_RS12455	COG2168	tRNA wobble position uridine thiolation
TBD_RS12460	COG2923	Belongs to the DsrF TusC family
TBD_RS12465	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
TBD_RS12470	COG2221	Nitrite and sulphite reductase 4Fe-4S
TBD_RS12475	COG2221	Nitrite and sulphite reductase 4Fe-4S
TBD_RS12510	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TBD_RS12515	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TBD_RS12520	COG2890	protein-(glutamine-N5) methyltransferase activity
TBD_RS12545	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TBD_RS12555	COG3852	Histidine kinase
TBD_RS12565	COG0174	glutamine synthetase
TBD_RS12570	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TBD_RS12575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TBD_RS12580	COG2239	Acts as a magnesium transporter
TBD_RS12585	COG1132	(ABC) transporter
TBD_RS12590	COG0037	tRNA processing
TBD_RS12595	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TBD_RS12635	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TBD_RS12645	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TBD_RS12655	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TBD_RS12665	COG1560	Kdo2-lipid A biosynthetic process
TBD_RS12675	COG1832	CoA-binding protein
TBD_RS12680	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TBD_RS12695	COG2326	polyphosphate kinase activity
TBD_RS12705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TBD_RS12720	COG0523	cobalamin synthesis protein
TBD_RS12725	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TBD_RS12735	COG3746	phosphate-selective porin O and P
TBD_RS12745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TBD_RS12755	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TBD_RS12760	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TBD_RS12790	COG0643	Histidine kinase
TBD_RS12790	COG2198	Histidine kinase
TBD_RS12790	COG0784	Response regulator, receiver
TBD_RS12825	COG0351	phosphomethylpyrimidine kinase
TBD_RS12830	COG0352	thiamine-phosphate diphosphorylase activity
TBD_RS12835	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TBD_RS12845	COG4232	protein-disulfide reductase activity
TBD_RS12850	COG1324	tolerance protein
TBD_RS12865	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TBD_RS12865	COG0543	2 iron, 2 sulfur cluster binding
TBD_RS12880	COG2959	enzyme of heme biosynthesis
TBD_RS12890	COG0181	hydroxymethylbilane synthase activity
TBD_RS12905	COG0784	Response regulator, receiver
TBD_RS12905	COG2198	Histidine kinase
TBD_RS12905	COG2205	protein histidine kinase activity
TBD_RS12910	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TBD_RS12915	COG3150	esterase
TBD_RS12920	COG0557	exoribonuclease II activity
TBD_RS12930	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
TBD_RS12940	COG1678	Uncharacterized ACR, COG1678
TBD_RS12945	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TBD_RS12950	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TBD_RS12955	COG0540	Belongs to the ATCase OTCase family
TBD_RS12965	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TBD_RS12975	COG0756	dUTP diphosphatase activity
TBD_RS12980	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TBD_RS12985	COG2003	Belongs to the UPF0758 family
TBD_RS12990	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TBD_RS12995	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TBD_RS13000	COG4771	TonB-dependent receptor
TBD_RS13010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TBD_RS13020	COG3264	Mechanosensitive ion channel
TBD_RS13020	COG1511	domain protein
TBD_RS13030	COG1022	Amp-dependent synthetase and ligase
TBD_RS13035	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TBD_RS13035	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TBD_RS13050	COG0628	permease
TBD_RS13055	COG0861	Integral membrane protein TerC family
TBD_RS13060	COG0501	Belongs to the peptidase M48B family
TBD_RS13065	COG0583	DNA-binding transcription factor activity
TBD_RS13075	COG3118	belongs to the thioredoxin family
TBD_RS13095	COG0642	Histidine kinase
TBD_RS13100	COG0745	RESPONSE REGULATOR receiver
TBD_RS13110	COG0730	response to heat
TBD_RS13115	COG0589	response to stress
TBD_RS13125	COG0659	secondary active sulfate transmembrane transporter activity
TBD_RS13140	COG1872	DUF167
TBD_RS13155	COG4451	ribulose bisphosphate carboxylase, small
TBD_RS13160	COG1850	ribulose-bisphosphate carboxylase activity
TBD_RS13165	COG0583	DNA-binding transcription factor activity
TBD_RS13170	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
TBD_RS13185	COG0616	signal peptide processing
TBD_RS13195	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TBD_RS13200	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TBD_RS13210	COG4251	negative regulation of phosphorylation
TBD_RS13210	COG3706	GGDEF domain
TBD_RS13210	COG5001	Diguanylate cyclase
TBD_RS13210	COG2203	Gaf domain
TBD_RS13235	COG1850	ribulose-bisphosphate carboxylase activity
TBD_RS13245	COG0659	secondary active sulfate transmembrane transporter activity
TBD_RS13255	COG1192	Involved in chromosome partitioning
TBD_RS13260	COG2154	pterin-4-alpha-carbinolamine dehydratase
TBD_RS13265	COG2193	ferroxidase activity
TBD_RS13270	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TBD_RS13275	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TBD_RS13280	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TBD_RS13315	COG3002	Belongs to the UPF0753 family
TBD_RS13325	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TBD_RS13340	COG2920	part of a sulfur-relay system
TBD_RS13355	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TBD_RS13360	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TBD_RS13380	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TBD_RS13385	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TBD_RS13390	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TBD_RS13405	COG0784	Response regulator, receiver
TBD_RS13405	COG2198	Histidine kinase
TBD_RS13405	COG2205	protein histidine kinase activity
TBD_RS13410	COG1024	Enoyl-CoA hydratase
TBD_RS13415	COG0730	response to heat
TBD_RS13440	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TBD_RS13460	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TBD_RS13470	COG4771	TonB-dependent receptor
TBD_RS13480	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
TBD_RS13490	COG1968	undecaprenyl-diphosphatase activity
TBD_RS13495	COG3706	GGDEF domain
TBD_RS13500	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TBD_RS13505	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TBD_RS13510	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TBD_RS13515	COG1538	Outer membrane efflux protein
TBD_RS13545	COG4535	Mg2 and Co2 transporter CorC
TBD_RS13550	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TBD_RS13555	COG1702	phosphate starvation-inducible protein PhoH
TBD_RS13560	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TBD_RS13570	COG1272	protein, Hemolysin III
TBD_RS13580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TBD_RS13585	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TBD_RS13595	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TBD_RS13605	COG1492	cobalamin metabolic process
TBD_RS13620	COG0778	Nitroreductase
TBD_RS13635	COG4206	TonB-dependent receptor
TBD_RS13650	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TBD_RS13655	COG1115	amino acid carrier protein
TBD_RS13660	COG4654	Cytochrome c, class I
TBD_RS13665	COG1331	Highly conserved protein containing a thioredoxin domain
TBD_RS13680	COG0129	dihydroxy-acid dehydratase activity
TBD_RS13685	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TBD_RS13705	COG2814	Major facilitator Superfamily
TBD_RS13725	COG0477	Major facilitator Superfamily
TBD_RS13730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TBD_RS13730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TBD_RS13735	COG0640	Transcriptional regulator
TBD_RS13740	COG2217	Heavy metal translocating P-type atpase
TBD_RS13800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TBD_RS13805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TBD_RS13820	COG1028	Short-chain dehydrogenase reductase Sdr
TBD_RS13825	COG0475	glutathione-regulated potassium exporter activity
TBD_RS13830	COG2226	methyltransferase
TBD_RS13860	COG2323	membrane
TBD_RS13875	COG0070	glutamate synthase
TBD_RS13875	COG0069	glutamate synthase activity
TBD_RS13875	COG0067	glutamate synthase
TBD_RS13880	COG0493	'glutamate synthase
TBD_RS13885	COG2205	protein histidine kinase activity
TBD_RS13895	COG2204	response regulator
TBD_RS13930	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TBD_RS13940	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TBD_RS13945	COG0018	arginyl-trna synthetase
TBD_RS13955	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TBD_RS13965	COG2197	response regulator
TBD_RS13975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TBD_RS13980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TBD_RS14005	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TBD_RS14010	COG2885	chlorophyll binding
TBD_RS14015	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TBD_RS14020	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TBD_RS14025	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TBD_RS14030	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TBD_RS14035	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TBD_RS14040	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TBD_RS14050	COG0356	it plays a direct role in the translocation of protons across the membrane
TBD_RS14065	COG1192	Involved in chromosome partitioning
TBD_RS14070	COG0357	Ribosomal RNA small subunit methyltransferase G
TBD_RS14075	COG0445	tRNA wobble uridine modification
TBD_RS14085	COG0488	(ABC) transporter
TBD_RS14090	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TBD_RS14095	COG1984	allophanate hydrolase subunit 2
TBD_RS14100	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TBD_RS14105	COG3706	GGDEF domain
TBD_RS14110	COG0513	Belongs to the DEAD box helicase family
TBD_RS14130	COG0582	viral genome integration into host DNA
TBD_RS14135	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TBD_RS14140	COG0706	membrane insertase activity
TBD_RS14145	COG0594	ribonuclease P activity
TBD_RS14150	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TBD_RS14215	COG2353	YceI-like domain
TBD_RS14225	COG5001	Diguanylate cyclase
TBD_RS14225	COG4251	negative regulation of phosphorylation
TBD_RS14225	COG3706	GGDEF domain
TBD_RS14225	COG2203	Gaf domain
TBD_RS14245	COG1742	UPF0060 membrane protein
TBD_RS14265	COG3300	MHYT domain
TBD_RS14265	COG5001	Diguanylate cyclase
TBD_RS14295	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TBD_RS14300	COG1215	transferase activity, transferring glycosyl groups
TBD_RS14315	COG4969	Belongs to the N-Me-Phe pilin family
TBD_RS14330	COG0484	heat shock protein binding