locus-tag	class	description
THIVI_RS00025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THIVI_RS00035	COG0436	Aminotransferase
THIVI_RS00055	COG2183	response to ionizing radiation
THIVI_RS00090	COG0333	Belongs to the bacterial ribosomal protein bL32 family
THIVI_RS00095	COG0416	fatty acid biosynthetic process
THIVI_RS00100	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THIVI_RS00115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THIVI_RS00120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THIVI_RS00125	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
THIVI_RS00130	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
THIVI_RS00135	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
THIVI_RS00150	COG0084	hydrolase, TatD family'
THIVI_RS00155	COG2995	paraquat-inducible protein a
THIVI_RS00160	COG3008	intermembrane lipid transfer
THIVI_RS00180	COG0745	RESPONSE REGULATOR receiver
THIVI_RS00185	COG2205	protein histidine kinase activity
THIVI_RS00195	COG0840	transmembrane signaling receptor activity
THIVI_RS00205	COG0784	Response regulator, receiver
THIVI_RS00205	COG2205	protein histidine kinase activity
THIVI_RS00205	COG2198	Histidine kinase
THIVI_RS00215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THIVI_RS00230	COG0189	ligase activity
THIVI_RS00230	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THIVI_RS00240	COG1132	(ABC) transporter
THIVI_RS00245	COG2843	Capsule synthesis protein
THIVI_RS00260	COG0439	Biotin carboxylase
THIVI_RS00275	COG4536	flavin adenine dinucleotide binding
THIVI_RS00280	COG0531	amino acid
THIVI_RS00290	COG0531	amino acid
THIVI_RS00300	COG0569	domain protein
THIVI_RS00305	COG1477	protein flavinylation
THIVI_RS00310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THIVI_RS00320	COG0730	response to heat
THIVI_RS00360	COG4658	electron transport chain
THIVI_RS00365	COG4656	Part of a membrane complex involved in electron transport
THIVI_RS00370	COG2878	Part of a membrane complex involved in electron transport
THIVI_RS00375	COG4657	Part of a membrane complex involved in electron transport
THIVI_RS00390	COG2205	protein histidine kinase activity
THIVI_RS00410	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
THIVI_RS00415	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
THIVI_RS00420	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
THIVI_RS00445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THIVI_RS00455	COG3909	cytochrome
THIVI_RS00470	COG0720	synthase
THIVI_RS00475	COG0602	queuosine metabolic process
THIVI_RS00485	COG0617	tRNA 3'-terminal CCA addition
THIVI_RS00490	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
THIVI_RS00495	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
THIVI_RS00500	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
THIVI_RS00510	COG0297	glycogen (starch) synthase activity
THIVI_RS00515	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
THIVI_RS00525	COG0166	Belongs to the GPI family
THIVI_RS00530	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THIVI_RS00540	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
THIVI_RS00550	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
THIVI_RS00570	COG3721	Heme iron utilization protein
THIVI_RS00580	COG0735	belongs to the Fur family
THIVI_RS00630	COG0438	transferase activity, transferring glycosyl groups
THIVI_RS00640	COG1215	transferase activity, transferring glycosyl groups
THIVI_RS00660	COG0438	transferase activity, transferring glycosyl groups
THIVI_RS00670	COG1216	Glycosyl transferase, family 2
THIVI_RS00740	COG0714	Associated with various cellular activities
THIVI_RS00755	COG0672	)-iron permease
THIVI_RS00790	COG3038	cytochrome b561
THIVI_RS00805	COG1196	nuclear chromosome segregation
THIVI_RS00805	COG0739	heme binding
THIVI_RS00805	COG0741	lytic transglycosylase activity
THIVI_RS00890	COG1459	type II secretion system
THIVI_RS00895	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THIVI_RS01015	COG0546	phosphoglycolate phosphatase activity
THIVI_RS01020	COG0714	Associated with various cellular activities
THIVI_RS01040	COG0604	alcohol dehydrogenase
THIVI_RS01050	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THIVI_RS01055	COG0560	Phosphoserine phosphatase
THIVI_RS01055	COG3830	Belongs to the UPF0237 family
THIVI_RS01065	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
THIVI_RS01075	COG1509	lysine 2,3-aminomutase activity
THIVI_RS01080	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
THIVI_RS01085	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
THIVI_RS01100	COG1408	metallophosphoesterase
THIVI_RS01120	COG2766	serine protein kinase
THIVI_RS01125	COG2718	Belongs to the UPF0229 family
THIVI_RS01130	COG2719	SpoVR family
THIVI_RS01140	COG2989	Protein conserved in bacteria
THIVI_RS01145	COG0418	dihydroorotase activity
THIVI_RS01150	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
THIVI_RS01160	COG0237	dephospho-CoA kinase activity
THIVI_RS01185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THIVI_RS01200	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
THIVI_RS01245	COG1294	oxidase, subunit
THIVI_RS01250	COG1271	oxidase subunit
THIVI_RS01270	COG0488	(ABC) transporter
THIVI_RS01275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
THIVI_RS01275	COG1263	PTS System
THIVI_RS01290	COG2270	Major facilitator Superfamily
THIVI_RS01305	COG2723	6-phospho-beta-galactosidase activity
THIVI_RS01325	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THIVI_RS01325	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THIVI_RS01370	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
THIVI_RS01375	COG4251	negative regulation of phosphorylation
THIVI_RS01380	COG4251	negative regulation of phosphorylation
THIVI_RS01390	COG4566	intracellular signal transduction
THIVI_RS01400	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THIVI_RS01430	COG0306	phosphate transporter
THIVI_RS01435	COG1392	Phosphate transport regulator
THIVI_RS01440	COG0776	regulation of translation
THIVI_RS01445	COG0539	negative regulation of cytoplasmic translation
THIVI_RS01450	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
THIVI_RS01455	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
THIVI_RS01480	COG0745	RESPONSE REGULATOR receiver
THIVI_RS01490	COG0643	Histidine kinase
THIVI_RS01490	COG2198	Histidine kinase
THIVI_RS01495	COG0840	transmembrane signaling receptor activity
THIVI_RS01500	COG0835	chemotaxis
THIVI_RS01505	COG2076	Multidrug Resistance protein
THIVI_RS01510	COG2201	protein-glutamate methylesterase activity
THIVI_RS01520	COG3447	MASE1 domain protein
THIVI_RS01520	COG5001	Diguanylate cyclase
THIVI_RS01520	COG5002	protein histidine kinase activity
THIVI_RS01525	COG0643	Histidine kinase
THIVI_RS01525	COG2198	Histidine kinase
THIVI_RS01530	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
THIVI_RS01535	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
THIVI_RS01540	COG2201	protein-glutamate methylesterase activity
THIVI_RS01555	COG2201	protein-glutamate methylesterase activity
THIVI_RS01565	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
THIVI_RS01575	COG0784	Response regulator, receiver
THIVI_RS01575	COG0643	Histidine kinase
THIVI_RS01575	COG2198	Histidine kinase
THIVI_RS01585	COG0745	RESPONSE REGULATOR receiver
THIVI_RS01590	COG0840	transmembrane signaling receptor activity
THIVI_RS01595	COG1366	Belongs to the anti-sigma-factor antagonist family
THIVI_RS01600	COG1366	Belongs to the anti-sigma-factor antagonist family
THIVI_RS01605	COG2172	sigma factor antagonist activity
THIVI_RS01610	COG2172	sigma factor antagonist activity
THIVI_RS01625	COG0745	RESPONSE REGULATOR receiver
THIVI_RS01630	COG1192	Involved in chromosome partitioning
THIVI_RS01635	COG0840	transmembrane signaling receptor activity
THIVI_RS01720	COG1677	Flagellar hook-basal body complex protein FliE
THIVI_RS01725	COG1766	The M ring may be actively involved in energy transduction
THIVI_RS01730	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THIVI_RS01785	COG1684	flagellar biosynthetic protein fliR
THIVI_RS01820	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
THIVI_RS01835	COG0784	Response regulator, receiver
THIVI_RS01835	COG2198	Histidine kinase
THIVI_RS01835	COG0643	Histidine kinase
THIVI_RS01840	COG2201	protein-glutamate methylesterase activity
THIVI_RS01845	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
THIVI_RS01850	COG1360	Flagellar Motor Protein
THIVI_RS01870	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THIVI_RS01905	COG0784	Response regulator, receiver
THIVI_RS01905	COG0835	chemotaxis
THIVI_RS01910	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
THIVI_RS01915	COG1815	bacterial-type flagellum-dependent cell motility
THIVI_RS01920	COG1558	bacterial-type flagellum-dependent cell motility
THIVI_RS01930	COG1749	Flagellar hook protein flgE
THIVI_RS01945	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
THIVI_RS01950	COG1706	bacterial-type flagellum-dependent cell motility
THIVI_RS01955	COG3951	Flagellar rod assembly protein muramidase FlgJ
THIVI_RS01955	COG1705	Flagellar rod assembly protein muramidase FlgJ
THIVI_RS01965	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THIVI_RS01980	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
THIVI_RS01985	COG1923	regulation of RNA biosynthetic process
THIVI_RS01990	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
THIVI_RS01995	COG0330	HflC and HflK could
THIVI_RS02000	COG0330	HflC and HflK could
THIVI_RS02015	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
THIVI_RS02020	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
THIVI_RS02050	COG5433	transposase activity
THIVI_RS02070	COG3093	addiction module antidote protein HigA
THIVI_RS02095	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
THIVI_RS02105	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
THIVI_RS02110	COG0840	transmembrane signaling receptor activity
THIVI_RS02110	COG0840	transmembrane signaling receptor activity
THIVI_RS02120	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THIVI_RS02125	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
THIVI_RS02130	COG1686	Belongs to the peptidase S11 family
THIVI_RS02135	COG1272	protein, Hemolysin III
THIVI_RS02140	COG2900	Belongs to the SlyX family
THIVI_RS02155	COG0735	belongs to the Fur family
THIVI_RS02200	COG1203	CRISPR-associated helicase, Cas3
THIVI_RS02215	COG1857	crispr-associated protein
THIVI_RS02245	COG1518	maintenance of DNA repeat elements
THIVI_RS02250	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
THIVI_RS02255	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
THIVI_RS02270	COG0673	inositol 2-dehydrogenase activity
THIVI_RS02295	COG0268	Binds directly to 16S ribosomal RNA
THIVI_RS02300	COG1125	glycine betaine transport
THIVI_RS02300	COG0517	IMP dehydrogenase activity
THIVI_RS02315	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
THIVI_RS02325	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
THIVI_RS02330	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THIVI_RS02360	COG0300	oxidoreductase activity
THIVI_RS02370	COG2885	chlorophyll binding
THIVI_RS02370	COG3047	cAMP biosynthetic process
THIVI_RS02375	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
THIVI_RS02380	COG0857	belongs to the CobB CobQ family
THIVI_RS02380	COG0280	phosphate acetyltransferase
THIVI_RS02390	COG2111	Na H antiporter
THIVI_RS02390	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THIVI_RS02395	COG0650	Formate hydrogenlyase subunit 4
THIVI_RS02400	COG3260	NADH ubiquinone oxidoreductase 20
THIVI_RS02405	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THIVI_RS02410	COG3261	NADH dehydrogenase
THIVI_RS02410	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
THIVI_RS02420	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
THIVI_RS02425	COG1592	Rubrerythrin
THIVI_RS02435	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
THIVI_RS02440	COG0585	pseudouridine synthase activity
THIVI_RS02465	COG2010	Cytochrome c
THIVI_RS02485	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
THIVI_RS02500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THIVI_RS02505	COG0557	exoribonuclease II activity
THIVI_RS02515	COG4106	trans-aconitate 2-methyltransferase activity
THIVI_RS02555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THIVI_RS02560	COG1132	(ABC) transporter
THIVI_RS02565	COG0704	Plays a role in the regulation of phosphate uptake
THIVI_RS02570	COG2200	EAL domain
THIVI_RS02570	COG2199	diguanylate cyclase activity
THIVI_RS02570	COG2203	Gaf domain
THIVI_RS02575	COG0840	transmembrane signaling receptor activity
THIVI_RS02590	COG1028	Short-chain dehydrogenase reductase Sdr
THIVI_RS02595	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
THIVI_RS02600	COG0284	orotidine-5'-phosphate decarboxylase activity
THIVI_RS02605	COG1210	Utp--glucose-1-phosphate uridylyltransferase
THIVI_RS02620	COG2920	part of a sulfur-relay system
THIVI_RS02645	COG2221	Nitrite and sulphite reductase 4Fe-4S
THIVI_RS02650	COG2221	Nitrite and sulphite reductase 4Fe-4S
THIVI_RS02655	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
THIVI_RS02660	COG2923	Belongs to the DsrF TusC family
THIVI_RS02670	COG2920	part of a sulfur-relay system
THIVI_RS02705	COG1797	cobyrinic acid a,c-diamide synthase activity
THIVI_RS02715	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
THIVI_RS02725	COG0745	RESPONSE REGULATOR receiver
THIVI_RS02750	COG2957	Belongs to the agmatine deiminase family
THIVI_RS02765	COG0670	Belongs to the BI1 family
THIVI_RS02860	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
THIVI_RS02875	COG0732	type I restriction modification DNA specificity domain
THIVI_RS02880	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
THIVI_RS02890	COG5433	transposase activity
THIVI_RS02895	COG0582	viral genome integration into host DNA
THIVI_RS02905	COG0123	including yeast histone deacetylase and acetoin utilization protein
THIVI_RS02945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THIVI_RS02950	COG0481	GTPase activity
THIVI_RS02955	COG0681	Belongs to the peptidase S26 family
THIVI_RS02975	COG1381	Involved in DNA repair and RecF pathway recombination
THIVI_RS02980	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
THIVI_RS02990	COG1404	Belongs to the peptidase S8 family
THIVI_RS02995	COG0243	molybdopterin cofactor binding
THIVI_RS03005	COG1534	Rna-binding protein
THIVI_RS03010	COG0033	Phosphoglucomutase
THIVI_RS03015	COG0326	Molecular chaperone. Has ATPase activity
THIVI_RS03020	COG0563	adenylate kinase activity
THIVI_RS03025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THIVI_RS03035	COG1959	2 iron, 2 sulfur cluster binding
THIVI_RS03060	COG0740	serine-type endopeptidase activity
THIVI_RS03065	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
THIVI_RS03070	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THIVI_RS03090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THIVI_RS03095	COG2086	electron transfer activity
THIVI_RS03100	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
THIVI_RS03105	COG1960	acyl-CoA dehydrogenase activity
THIVI_RS03110	COG2304	oxidoreductase activity
THIVI_RS03120	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
THIVI_RS03130	COG3706	GGDEF domain
THIVI_RS03145	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
THIVI_RS03150	COG0745	RESPONSE REGULATOR receiver
THIVI_RS03170	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
THIVI_RS03185	COG1131	(ABC) transporter
THIVI_RS03195	COG1286	toxin biosynthetic process
THIVI_RS03220	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THIVI_RS03235	COG0071	Belongs to the small heat shock protein (HSP20) family
THIVI_RS03260	COG0217	transcriptional regulatory protein
THIVI_RS03270	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
THIVI_RS03275	COG0632	four-way junction helicase activity
THIVI_RS03285	COG0277	FAD linked oxidase domain protein
THIVI_RS03290	COG0247	lactate metabolic process
THIVI_RS03295	COG2084	Dehydrogenase
THIVI_RS03305	COG3876	Protein conserved in bacteria
THIVI_RS03310	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
THIVI_RS03320	COG0513	Belongs to the DEAD box helicase family
THIVI_RS03325	COG0724	RNA recognition motif
THIVI_RS03335	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
THIVI_RS03335	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
THIVI_RS03345	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
THIVI_RS03360	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
THIVI_RS03365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
THIVI_RS03390	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
THIVI_RS03395	COG2354	Protein conserved in bacteria
THIVI_RS03400	COG3154	lipid carrier protein
THIVI_RS03415	COG2862	Uncharacterized protein family, UPF0114
THIVI_RS03420	COG3706	GGDEF domain
THIVI_RS03420	COG2203	Gaf domain
THIVI_RS03420	COG4251	negative regulation of phosphorylation
THIVI_RS03420	COG5001	Diguanylate cyclase
THIVI_RS03435	COG2814	Major facilitator Superfamily
THIVI_RS03465	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THIVI_RS03475	COG2337	Toxic component of a toxin-antitoxin (TA) module
THIVI_RS03480	COG2336	PFAM SpoVT AbrB
THIVI_RS03485	COG4206	TonB-dependent receptor
THIVI_RS03495	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
THIVI_RS03515	COG2333	competence protein COMEC
THIVI_RS03515	COG0658	competence protein
THIVI_RS03530	COG1136	(ABC) transporter
THIVI_RS03535	COG4591	ABC-type transport system involved in lipoprotein release permease component
THIVI_RS03540	COG0795	lipopolysaccharide-transporting ATPase activity
THIVI_RS03550	COG0308	aminopeptidase N
THIVI_RS03585	COG3174	membrane
THIVI_RS03600	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
THIVI_RS03605	COG0676	glucose-6-phosphate 1-epimerase activity
THIVI_RS03610	COG3459	Glycosyltransferase 36 associated
THIVI_RS03625	COG0527	aspartate kinase activity
THIVI_RS03630	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
THIVI_RS03635	COG2137	regulation of response to DNA damage stimulus
THIVI_RS03645	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
THIVI_RS03650	COG1546	Belongs to the CinA family
THIVI_RS03680	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THIVI_RS03690	COG0463	Glycosyl transferase, family 2
THIVI_RS03695	COG3028	Belongs to the UPF0307 family
THIVI_RS03705	COG0577	efflux transmembrane transporter activity
THIVI_RS03705	COG1136	(ABC) transporter
THIVI_RS03710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THIVI_RS03760	COG0271	Belongs to the BolA IbaG family
THIVI_RS03765	COG1115	amino acid carrier protein
THIVI_RS03785	COG1334	flagellar protein FlaG
THIVI_RS03810	COG5002	protein histidine kinase activity
THIVI_RS03815	COG0745	RESPONSE REGULATOR receiver
THIVI_RS03890	COG0457	Tetratricopeptide repeat
THIVI_RS03910	COG2801	Transposase and inactivated derivatives
THIVI_RS03930	COG3956	TIGRFAM MazG family protein
THIVI_RS03940	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
THIVI_RS03960	COG0589	response to stress
THIVI_RS03975	COG1136	(ABC) transporter
THIVI_RS03975	COG0577	efflux transmembrane transporter activity
THIVI_RS04080	COG1104	cysteine desulfurase activity
THIVI_RS04095	COG3118	belongs to the thioredoxin family
THIVI_RS04105	COG0037	tRNA processing
THIVI_RS04115	COG0825	malonyl-CoA metabolic process
THIVI_RS04160	COG4191	Histidine kinase
THIVI_RS04165	COG4566	intracellular signal transduction
THIVI_RS04175	COG3012	SEC-C Motif Domain Protein
THIVI_RS04205	COG1342	Belongs to the UPF0251 family
THIVI_RS04210	COG0723	plastoquinol--plastocyanin reductase activity
THIVI_RS04230	COG2894	cell division
THIVI_RS04265	COG4566	intracellular signal transduction
THIVI_RS04280	COG2304	oxidoreductase activity
THIVI_RS04290	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THIVI_RS04330	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
THIVI_RS04355	COG0386	Belongs to the glutathione peroxidase family
THIVI_RS04360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
THIVI_RS04365	COG0671	phosphoesterase, PA-phosphatase related
THIVI_RS04370	COG2046	Belongs to the sulfate adenylyltransferase family
THIVI_RS04380	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
THIVI_RS04385	COG3108	Peptidase M15
THIVI_RS04390	COG0557	exoribonuclease II activity
THIVI_RS04405	COG0493	'glutamate synthase
THIVI_RS04415	COG0601	transmembrane transport
THIVI_RS04420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THIVI_RS04425	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
THIVI_RS04455	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
THIVI_RS04460	COG0285	dihydrofolate synthase activity
THIVI_RS04465	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
THIVI_RS04470	COG0159	tryptophan synthase activity
THIVI_RS04475	COG0133	tryptophan synthase activity
THIVI_RS04480	COG0135	phosphoribosylanthranilate isomerase activity
THIVI_RS04485	COG0101	tRNA pseudouridine synthase activity
THIVI_RS04500	COG0473	3-isopropylmalate dehydrogenase activity
THIVI_RS04505	COG0066	3-isopropylmalate dehydratase activity
THIVI_RS04510	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THIVI_RS04515	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
THIVI_RS04530	COG1136	(ABC) transporter
THIVI_RS04530	COG0577	efflux transmembrane transporter activity
THIVI_RS04535	COG0577	efflux transmembrane transporter activity
THIVI_RS04535	COG1136	(ABC) transporter
THIVI_RS04540	COG0577	efflux transmembrane transporter activity
THIVI_RS04540	COG1136	(ABC) transporter
THIVI_RS04550	COG0735	belongs to the Fur family
THIVI_RS04555	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THIVI_RS04560	COG2914	Belongs to the UPF0125 (RnfH) family
THIVI_RS04565	COG2867	negative regulation of translational initiation
THIVI_RS04570	COG0733	neurotransmitter:sodium symporter activity
THIVI_RS04575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THIVI_RS04585	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
THIVI_RS04600	COG0791	NLP P60 protein
THIVI_RS04605	COG0492	ferredoxin-NADP+ reductase activity
THIVI_RS04615	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
THIVI_RS04620	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
THIVI_RS04625	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
THIVI_RS04695	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
THIVI_RS04710	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
THIVI_RS04715	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THIVI_RS04720	COG0581	inorganic phosphate transmembrane transporter activity
THIVI_RS04725	COG0573	inorganic phosphate transmembrane transporter activity
THIVI_RS04740	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
THIVI_RS04745	COG0058	SHG alpha-glucan phosphorylase activity
THIVI_RS04750	COG2326	polyphosphate kinase activity
THIVI_RS04760	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
THIVI_RS04765	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
THIVI_RS04785	COG4636	protein conserved in cyanobacteria
THIVI_RS04790	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
THIVI_RS04800	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
THIVI_RS04805	COG0495	leucyl-tRNA aminoacylation
THIVI_RS04815	COG0542	response to heat
THIVI_RS04835	COG0501	Belongs to the peptidase M48B family
THIVI_RS04845	COG0302	gtp cyclohydrolase
THIVI_RS04850	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
THIVI_RS04895	COG0028	Belongs to the TPP enzyme family
THIVI_RS04905	COG0442	prolyl-tRNA aminoacylation
THIVI_RS04910	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THIVI_RS04920	COG2205	protein histidine kinase activity
THIVI_RS04920	COG5002	protein histidine kinase activity
THIVI_RS04920	COG0784	Response regulator, receiver
THIVI_RS04925	COG3437	response regulator, receiver
THIVI_RS04930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THIVI_RS04950	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
THIVI_RS04985	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
THIVI_RS04995	COG2379	hydroxypyruvate reductase
THIVI_RS05005	COG0494	nUDIX hydrolase
THIVI_RS05010	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
THIVI_RS05020	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THIVI_RS05025	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
THIVI_RS05030	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THIVI_RS05035	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THIVI_RS05035	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THIVI_RS05055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THIVI_RS05060	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
THIVI_RS05075	COG2217	Heavy metal translocating P-type atpase
THIVI_RS05095	COG2010	Cytochrome c
THIVI_RS05110	COG3278	Belongs to the heme-copper respiratory oxidase family
THIVI_RS05115	COG2212	antiporter activity
THIVI_RS05120	COG1320	monovalent cation:proton antiporter activity
THIVI_RS05135	COG1006	Multisubunit Na H antiporter MnhC subunit
THIVI_RS05140	COG0651	ATP synthesis coupled electron transport
THIVI_RS05145	COG0651	ATP synthesis coupled electron transport
THIVI_RS05150	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
THIVI_RS05155	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THIVI_RS05160	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THIVI_RS05165	COG0649	NAD binding
THIVI_RS05180	COG1863	multisubunit Na H antiporter MnhE subunit
THIVI_RS05195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THIVI_RS05215	COG2835	tetraacyldisaccharide 4'-kinase activity
THIVI_RS05235	COG1518	maintenance of DNA repeat elements
THIVI_RS05265	COG1203	CRISPR-associated helicase, Cas3
THIVI_RS05280	COG2151	metal-sulfur cluster biosynthetic enzyme
THIVI_RS05285	COG0719	Fe-S assembly protein
THIVI_RS05290	COG0396	ATPase activity
THIVI_RS05295	COG0719	Fe-S assembly protein
THIVI_RS05305	COG2200	EAL domain
THIVI_RS05330	COG1324	tolerance protein
THIVI_RS05335	COG4232	protein-disulfide reductase activity
THIVI_RS05340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THIVI_RS05350	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
THIVI_RS05355	COG0511	ligase activity, forming carbon-carbon bonds
THIVI_RS05360	COG0439	Biotin carboxylase
THIVI_RS05375	COG2189	Belongs to the N(4) N(6)-methyltransferase family
THIVI_RS05395	COG4106	trans-aconitate 2-methyltransferase activity
THIVI_RS05405	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
THIVI_RS05415	COG0138	bifunctional purine biosynthesis protein purh
THIVI_RS05420	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THIVI_RS05430	COG0151	Belongs to the GarS family
THIVI_RS05455	COG3178	'Phosphotransferase
THIVI_RS05460	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
THIVI_RS05465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THIVI_RS05470	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
THIVI_RS05475	COG1183	phosphatidylcholine synthase activity
THIVI_RS05480	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
THIVI_RS05495	COG1034	ATP synthesis coupled electron transport
THIVI_RS05500	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
THIVI_RS05510	COG3259	Nickel-dependent hydrogenase
THIVI_RS05520	COG1028	Short-chain dehydrogenase reductase Sdr
THIVI_RS05525	COG1254	Belongs to the acylphosphatase family
THIVI_RS05545	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THIVI_RS05550	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
THIVI_RS05555	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
THIVI_RS05585	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
THIVI_RS05590	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
THIVI_RS05600	COG0180	Tryptophanyl-tRNA synthetase
THIVI_RS05605	COG1994	Peptidase M50
THIVI_RS05610	COG0009	L-threonylcarbamoyladenylate synthase
THIVI_RS05615	COG0613	PHP domain protein
THIVI_RS05640	COG3100	YcgL domain-containing protein
THIVI_RS05640	COG0561	phosphatase activity
THIVI_RS05645	COG0438	transferase activity, transferring glycosyl groups
THIVI_RS05650	COG0811	peptide transport
THIVI_RS05675	COG0004	ammonium transporteR
THIVI_RS05685	COG0310	cobalt ion transport
THIVI_RS05690	COG0310	cobalt ion transport
THIVI_RS05720	COG0864	Transcriptional regulator
THIVI_RS05735	COG2308	Evidence 4 Homologs of previously reported genes of
THIVI_RS05765	COG0359	binds to the 23S rRNA
THIVI_RS05780	COG0360	Binds together with S18 to 16S ribosomal RNA
THIVI_RS05830	COG0583	DNA-binding transcription factor activity
THIVI_RS05835	COG5433	transposase activity
THIVI_RS05840	COG2716	regulation of RNA biosynthetic process
THIVI_RS05845	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THIVI_RS05850	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
THIVI_RS05860	COG3437	response regulator, receiver
THIVI_RS05885	COG3437	response regulator, receiver
THIVI_RS05905	COG0840	transmembrane signaling receptor activity
THIVI_RS05915	COG2204	response regulator
THIVI_RS05925	COG0784	Response regulator, receiver
THIVI_RS05925	COG2205	protein histidine kinase activity
THIVI_RS05925	COG5002	protein histidine kinase activity
THIVI_RS05935	COG2205	protein histidine kinase activity
THIVI_RS05950	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
THIVI_RS05960	COG0840	transmembrane signaling receptor activity
THIVI_RS05965	COG0835	chemotaxis
THIVI_RS05970	COG2198	Histidine kinase
THIVI_RS05970	COG0643	Histidine kinase
THIVI_RS05975	COG0745	RESPONSE REGULATOR receiver
THIVI_RS05980	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
THIVI_RS06065	COG5001	Diguanylate cyclase
THIVI_RS06080	COG0542	response to heat
THIVI_RS06105	COG0277	FAD linked oxidase domain protein
THIVI_RS06125	COG1242	4 iron, 4 sulfur cluster binding
THIVI_RS06130	COG0826	peptidase U32
THIVI_RS06135	COG0826	peptidase U32
THIVI_RS06155	COG2308	Evidence 4 Homologs of previously reported genes of
THIVI_RS06160	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
THIVI_RS06190	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
THIVI_RS06200	COG2943	transferase activity, transferring hexosyl groups
THIVI_RS06210	COG2917	probably involved in intracellular septation
THIVI_RS06215	COG2350	Protein conserved in bacteria
THIVI_RS06220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THIVI_RS06230	COG3005	denitrification pathway
THIVI_RS06315	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
THIVI_RS06340	COG5433	transposase activity
THIVI_RS06355	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
THIVI_RS06380	COG4771	TonB-dependent receptor
THIVI_RS06385	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
THIVI_RS06390	COG3437	response regulator, receiver
THIVI_RS06390	COG4999	Histidine kinase
THIVI_RS06390	COG2205	protein histidine kinase activity
THIVI_RS06390	COG3850	Histidine kinase
THIVI_RS06410	COG5002	protein histidine kinase activity
THIVI_RS06410	COG5001	Diguanylate cyclase
THIVI_RS06415	COG0366	Alpha amylase catalytic
THIVI_RS06415	COG1874	Beta-galactosidase
THIVI_RS06420	COG0616	signal peptide processing
THIVI_RS06425	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
THIVI_RS06435	COG0688	phosphatidylethanolamine metabolic process
THIVI_RS06440	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
THIVI_RS06575	COG0628	permease
THIVI_RS06605	COG0415	Belongs to the DNA photolyase family
THIVI_RS06620	COG1968	undecaprenyl-diphosphatase activity
THIVI_RS06625	COG2983	Belongs to the UPF0260 family
THIVI_RS06640	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
THIVI_RS06655	COG2610	gluconate transmembrane transporter activity
THIVI_RS06690	COG0651	ATP synthesis coupled electron transport
THIVI_RS06695	COG3710	Transcriptional regulator
THIVI_RS06710	COG5002	protein histidine kinase activity
THIVI_RS06710	COG5001	Diguanylate cyclase
THIVI_RS06745	COG2235	arginine
THIVI_RS06780	COG0628	permease
THIVI_RS06790	COG0786	glutamate:sodium symporter activity
THIVI_RS06800	COG2066	Belongs to the glutaminase family
THIVI_RS06805	COG0583	DNA-binding transcription factor activity
THIVI_RS06810	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
THIVI_RS06820	COG0175	sulfate reduction
THIVI_RS06830	COG0277	FAD linked oxidase domain protein
THIVI_RS06840	COG0729	surface antigen
THIVI_RS06850	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THIVI_RS06865	COG0789	Transcriptional regulator
THIVI_RS06875	COG5433	transposase activity
THIVI_RS06885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THIVI_RS06890	COG0071	Belongs to the small heat shock protein (HSP20) family
THIVI_RS06940	COG4771	TonB-dependent receptor
THIVI_RS07060	COG5433	transposase activity
THIVI_RS07140	COG1196	nuclear chromosome segregation
THIVI_RS07330	COG5433	transposase activity
THIVI_RS07370	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THIVI_RS07450	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
THIVI_RS07535	COG0776	regulation of translation
THIVI_RS07540	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THIVI_RS07540	COG0072	phenylalanine-tRNA ligase activity
THIVI_RS07545	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
THIVI_RS07555	COG0291	Belongs to the bacterial ribosomal protein bL35 family
THIVI_RS07565	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THIVI_RS07580	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
THIVI_RS07590	COG1850	ribulose-bisphosphate carboxylase activity
THIVI_RS07615	COG2255	four-way junction helicase activity
THIVI_RS07620	COG0277	FAD linked oxidase domain protein
THIVI_RS07740	COG2197	response regulator
THIVI_RS07750	COG2205	protein histidine kinase activity
THIVI_RS07750	COG0784	Response regulator, receiver
THIVI_RS07750	COG5002	protein histidine kinase activity
THIVI_RS07855	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
THIVI_RS07885	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
THIVI_RS07930	COG5433	transposase activity
THIVI_RS08005	COG5433	transposase activity
THIVI_RS08050	COG0640	Transcriptional regulator
THIVI_RS08055	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THIVI_RS08060	COG0798	PFAM Bile acid sodium symporter
THIVI_RS08065	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
THIVI_RS08095	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
THIVI_RS08145	COG0583	DNA-binding transcription factor activity
THIVI_RS08150	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
THIVI_RS08170	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
THIVI_RS08180	COG1280	lysine exporter protein (LysE YggA)
THIVI_RS08195	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
THIVI_RS08200	COG1797	cobyrinic acid a,c-diamide synthase activity
THIVI_RS08215	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
THIVI_RS08220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THIVI_RS08260	COG1492	cobalamin metabolic process
THIVI_RS08290	COG1136	(ABC) transporter
THIVI_RS08310	COG0745	RESPONSE REGULATOR receiver
THIVI_RS08315	COG3437	response regulator, receiver
THIVI_RS08330	COG0516	GMP reductase activity
THIVI_RS08330	COG0517	IMP dehydrogenase activity
THIVI_RS08340	COG0488	(ABC) transporter
THIVI_RS08345	COG0446	pyridine nucleotide-disulphide oxidoreductase
THIVI_RS08365	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
THIVI_RS08370	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
THIVI_RS08380	COG2226	methyltransferase
THIVI_RS08395	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
THIVI_RS08400	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
THIVI_RS08420	COG0367	asparagine synthase
THIVI_RS08455	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THIVI_RS08465	COG2814	Major facilitator Superfamily
THIVI_RS08470	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
THIVI_RS08475	COG1538	Outer membrane efflux protein
THIVI_RS08480	COG0429	hydrolase of the alpha beta-hydrolase fold
THIVI_RS08490	COG0746	molybdenum cofactor guanylyltransferase activity
THIVI_RS08495	COG0071	Belongs to the small heat shock protein (HSP20) family
THIVI_RS08505	COG2307	Protein conserved in bacteria
THIVI_RS08505	COG2308	Evidence 4 Homologs of previously reported genes of
THIVI_RS08520	COG1040	competence protein
THIVI_RS08525	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THIVI_RS08530	COG0156	8-amino-7-oxononanoate synthase activity
THIVI_RS08535	COG0596	Alpha beta hydrolase
THIVI_RS08540	COG2226	methyltransferase
THIVI_RS08555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
THIVI_RS08560	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
THIVI_RS08565	COG0505	Belongs to the CarA family
THIVI_RS08605	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
THIVI_RS08610	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
THIVI_RS08645	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
THIVI_RS08655	COG1394	ATPase activity, coupled to movement of substances
THIVI_RS08660	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
THIVI_RS08685	COG0823	Involved in the tonB-independent uptake of proteins
THIVI_RS08705	COG0824	Thioesterase
THIVI_RS08715	COG0318	PFAM AMP-dependent synthetase and ligase
THIVI_RS08730	COG1528	Iron-storage protein
THIVI_RS08735	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
THIVI_RS08740	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
THIVI_RS08745	COG0795	lipopolysaccharide-transporting ATPase activity
THIVI_RS08750	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
THIVI_RS08755	COG0084	hydrolase, TatD family'
THIVI_RS08765	COG3122	Protein conserved in bacteria
THIVI_RS08775	COG0446	pyridine nucleotide-disulphide oxidoreductase
THIVI_RS08785	COG0446	pyridine nucleotide-disulphide oxidoreductase
THIVI_RS08810	COG1131	(ABC) transporter
THIVI_RS08830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THIVI_RS08835	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
THIVI_RS08840	COG1477	protein flavinylation
THIVI_RS08870	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
THIVI_RS08895	COG0404	The glycine cleavage system catalyzes the degradation of glycine
THIVI_RS08900	COG0509	glycine decarboxylation via glycine cleavage system
THIVI_RS08905	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THIVI_RS08910	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
THIVI_RS08915	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THIVI_RS08920	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
THIVI_RS08930	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
THIVI_RS08940	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
THIVI_RS08945	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
THIVI_RS08955	COG4535	Mg2 and Co2 transporter CorC
THIVI_RS08960	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
THIVI_RS08965	COG1702	phosphate starvation-inducible protein PhoH
THIVI_RS08970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THIVI_RS08995	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
THIVI_RS09000	COG2853	Lipoprotein
THIVI_RS09010	COG3706	GGDEF domain
THIVI_RS09025	COG0784	Response regulator, receiver
THIVI_RS09025	COG2198	Histidine kinase
THIVI_RS09025	COG5002	protein histidine kinase activity
THIVI_RS09035	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
THIVI_RS09050	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
THIVI_RS09055	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THIVI_RS09080	COG2373	Large extracellular alpha-helical protein
THIVI_RS09090	COG0824	Thioesterase
THIVI_RS09100	COG4145	pantothenate transmembrane transporter activity
THIVI_RS09110	COG0826	peptidase U32
THIVI_RS09190	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THIVI_RS09195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THIVI_RS09205	COG0737	Belongs to the 5'-nucleotidase family
THIVI_RS09220	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
THIVI_RS09225	COG0129	dihydroxy-acid dehydratase activity
THIVI_RS09285	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THIVI_RS09300	COG2027	D-alanyl-D-alanine carboxypeptidase
THIVI_RS09305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THIVI_RS09310	COG1047	Peptidyl-prolyl cis-trans
THIVI_RS09325	COG3954	Phosphoribulokinase
THIVI_RS09330	COG3850	Histidine kinase
THIVI_RS09330	COG3437	response regulator, receiver
THIVI_RS09330	COG2205	protein histidine kinase activity
THIVI_RS09330	COG4999	Histidine kinase
THIVI_RS09340	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THIVI_RS09350	COG4657	Part of a membrane complex involved in electron transport
THIVI_RS09355	COG2878	Part of a membrane complex involved in electron transport
THIVI_RS09365	COG4658	electron transport chain
THIVI_RS09370	COG4659	FMN binding
THIVI_RS09375	COG4660	Part of a membrane complex involved in electron transport
THIVI_RS09380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THIVI_RS09385	COG2827	Endonuclease containing a URI domain
THIVI_RS09435	COG1943	Transposase
THIVI_RS09450	COG0625	glutathione transferase activity
THIVI_RS09455	COG1414	Transcriptional regulator
THIVI_RS09480	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
THIVI_RS09525	COG1584	GPR1 FUN34 yaaH family protein
THIVI_RS09550	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
THIVI_RS09570	COG2814	Major facilitator Superfamily
THIVI_RS09615	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
THIVI_RS09620	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
THIVI_RS09625	COG1850	ribulose-bisphosphate carboxylase activity
THIVI_RS09675	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
THIVI_RS09695	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
THIVI_RS09700	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
THIVI_RS09705	COG1063	alcohol dehydrogenase
THIVI_RS09710	COG0500	methyltransferase
THIVI_RS09715	COG0142	geranyltranstransferase activity
THIVI_RS09755	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
THIVI_RS09760	COG1819	glycosyl
THIVI_RS09765	COG1562	ergosterol biosynthetic process
THIVI_RS09770	COG1233	COG1233 Phytoene dehydrogenase and related
THIVI_RS09775	COG1397	ADP-ribosylglycohydrolase
THIVI_RS09780	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
THIVI_RS09785	COG1074	ATP-dependent DNA helicase activity
THIVI_RS09790	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
THIVI_RS09800	COG0513	Belongs to the DEAD box helicase family
THIVI_RS09805	COG2226	methyltransferase
THIVI_RS09820	COG0631	protein serine/threonine phosphatase activity
THIVI_RS09875	COG5433	transposase activity
THIVI_RS09905	COG0631	protein serine/threonine phosphatase activity
THIVI_RS09970	COG1943	Transposase
THIVI_RS09980	COG0714	Associated with various cellular activities
THIVI_RS09985	COG1217	gtp-binding protein TYPA
THIVI_RS09995	COG1490	D-aminoacyl-tRNA deacylase activity
THIVI_RS10025	COG0215	cysteine-tRNA ligase activity
THIVI_RS10030	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
THIVI_RS10035	COG0830	nickel cation binding
THIVI_RS10040	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
THIVI_RS10045	COG0804	urea catabolic process
THIVI_RS10050	COG0832	Belongs to the urease beta subunit family
THIVI_RS10055	COG0831	urea catabolic process
THIVI_RS10060	COG0829	nickel cation binding
THIVI_RS10135	COG0840	transmembrane signaling receptor activity
THIVI_RS10140	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
THIVI_RS10140	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
THIVI_RS10150	COG1519	Transferase
THIVI_RS10170	COG0745	RESPONSE REGULATOR receiver
THIVI_RS10175	COG5002	protein histidine kinase activity
THIVI_RS10195	COG0058	SHG alpha-glucan phosphorylase activity
THIVI_RS10200	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
THIVI_RS10205	COG4636	protein conserved in cyanobacteria
THIVI_RS10210	COG0514	ATP-dependent DNA helicase (RecQ)
THIVI_RS10235	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
THIVI_RS10240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THIVI_RS10245	COG0077	Prephenate dehydratase
THIVI_RS10245	COG1605	Chorismate mutase
THIVI_RS10250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THIVI_RS10255	COG0287	Prephenate dehydrogenase
THIVI_RS10260	COG0704	Plays a role in the regulation of phosphate uptake
THIVI_RS10280	COG0426	domain, Protein
THIVI_RS10285	COG0633	Ferredoxin
THIVI_RS10370	COG0028	Belongs to the TPP enzyme family
THIVI_RS10380	COG4251	negative regulation of phosphorylation
THIVI_RS10385	COG0784	Response regulator, receiver
THIVI_RS10390	COG0784	Response regulator, receiver
THIVI_RS10390	COG2205	protein histidine kinase activity
THIVI_RS10395	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
THIVI_RS10415	COG0583	DNA-binding transcription factor activity
THIVI_RS10425	COG2824	Alkylphosphonate utilization operon protein PhnA
THIVI_RS10435	COG2210	Belongs to the sulfur carrier protein TusA family
THIVI_RS10440	COG0425	Belongs to the sulfur carrier protein TusA family
THIVI_RS10445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THIVI_RS10450	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
THIVI_RS10450	COG1648	precorrin-2 dehydrogenase activity
THIVI_RS10505	COG1358	cellular component organization or biogenesis
THIVI_RS10525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THIVI_RS10535	COG2823	Periplasmic or secreted lipoprotein
THIVI_RS10535	COG1652	LysM domain
THIVI_RS10565	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
THIVI_RS10575	COG0616	signal peptide processing
THIVI_RS10580	COG0546	phosphoglycolate phosphatase activity
THIVI_RS10595	COG1530	ribonuclease E activity
THIVI_RS10615	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THIVI_RS10645	COG4970	Tfp pilus assembly protein FimT
THIVI_RS10675	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
THIVI_RS10705	COG0189	ligase activity
THIVI_RS10705	COG0569	domain protein
THIVI_RS10725	COG2321	neutral zinc metallopeptidase
THIVI_RS10740	COG0165	Argininosuccinate lyase
THIVI_RS10755	COG0561	phosphatase activity
THIVI_RS10770	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THIVI_RS10775	COG1881	PFAM PEBP family protein
THIVI_RS10785	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
THIVI_RS10800	COG1137	ATPase activity
THIVI_RS10820	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
THIVI_RS10825	COG1660	Displays ATPase and GTPase activities
THIVI_RS10835	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
THIVI_RS10840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THIVI_RS10845	COG2239	Acts as a magnesium transporter
THIVI_RS10860	COG2226	methyltransferase
THIVI_RS10875	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
THIVI_RS10880	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THIVI_RS10900	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THIVI_RS10915	COG0463	Glycosyl transferase, family 2
THIVI_RS10945	COG1570	exodeoxyribonuclease VII activity
THIVI_RS10955	COG0516	GMP reductase activity
THIVI_RS10955	COG0517	IMP dehydrogenase activity
THIVI_RS10970	COG0519	Catalyzes the synthesis of GMP from XMP
THIVI_RS10970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THIVI_RS10985	COG1902	pentaerythritol trinitrate reductase activity
THIVI_RS10995	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THIVI_RS11015	COG3263	regulation of cellular component size
THIVI_RS11020	COG3123	guanosine phosphorylase activity
THIVI_RS11125	COG1360	Flagellar Motor Protein
THIVI_RS11155	COG0494	nUDIX hydrolase
THIVI_RS11160	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
THIVI_RS11165	COG0653	protein targeting
THIVI_RS11180	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
THIVI_RS11195	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
THIVI_RS11200	COG1181	Belongs to the D-alanine--D-alanine ligase family
THIVI_RS11205	COG0812	UDP-N-acetylmuramate dehydrogenase activity
THIVI_RS11210	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THIVI_RS11215	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THIVI_RS11220	COG0772	Belongs to the SEDS family
THIVI_RS11225	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
THIVI_RS11230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THIVI_RS11235	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
THIVI_RS11250	COG0275	rRNA processing
THIVI_RS11255	COG2001	Belongs to the MraZ family
THIVI_RS11260	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
THIVI_RS11265	COG3107	peptidoglycan biosynthetic process
THIVI_RS11270	COG0792	nuclease activity
THIVI_RS11275	COG2823	Periplasmic or secreted lipoprotein
THIVI_RS11280	COG0277	FAD linked oxidase domain protein
THIVI_RS11335	COG0126	phosphoglycerate kinase activity
THIVI_RS11355	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
THIVI_RS11360	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
THIVI_RS11370	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THIVI_RS11395	COG0840	transmembrane signaling receptor activity
THIVI_RS11415	COG4251	negative regulation of phosphorylation
THIVI_RS11430	COG0582	viral genome integration into host DNA
THIVI_RS11510	COG3437	response regulator, receiver
THIVI_RS11520	COG4251	negative regulation of phosphorylation
THIVI_RS11525	COG1598	PFAM Uncharacterised protein family UPF0150
THIVI_RS11530	COG1724	mRNA binding
THIVI_RS11545	COG0019	diaminopimelate decarboxylase activity
THIVI_RS11555	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
THIVI_RS11565	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
THIVI_RS11585	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
THIVI_RS11595	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
THIVI_RS11605	COG0318	PFAM AMP-dependent synthetase and ligase
THIVI_RS11610	COG1719	4-vinyl reductase, 4VR
THIVI_RS11650	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
THIVI_RS11655	COG1429	ligase activity, forming nitrogen-metal bonds
THIVI_RS11660	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
THIVI_RS11665	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
THIVI_RS11680	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
THIVI_RS11685	COG0644	oxidoreductase
THIVI_RS11690	COG1643	Atp-dependent helicase
THIVI_RS11730	COG1484	DNA-dependent DNA replication
THIVI_RS11770	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THIVI_RS11790	COG0768	penicillin binding
THIVI_RS11795	COG1441	menaquinone biosynthetic process
THIVI_RS11810	COG3267	Type II secretory pathway component ExeA
THIVI_RS11810	COG3409	Peptidoglycan-binding domain 1 protein
THIVI_RS11820	COG2239	Acts as a magnesium transporter
THIVI_RS11825	COG2202	Pas domain
THIVI_RS11825	COG2205	protein histidine kinase activity
THIVI_RS11830	COG2204	response regulator
THIVI_RS11855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THIVI_RS11865	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THIVI_RS11885	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THIVI_RS11905	COG1842	Phage shock protein A
THIVI_RS11940	COG5265	(ABC) transporter
THIVI_RS11945	COG3850	Histidine kinase
THIVI_RS11950	COG2197	response regulator
THIVI_RS11975	COG2814	Major facilitator Superfamily
THIVI_RS11995	COG1674	ftsk spoiiie
THIVI_RS12020	COG0438	transferase activity, transferring glycosyl groups
THIVI_RS12025	COG0438	transferase activity, transferring glycosyl groups
THIVI_RS12070	COG2801	Transposase and inactivated derivatives
THIVI_RS12085	COG2337	Toxic component of a toxin-antitoxin (TA) module
THIVI_RS12105	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
THIVI_RS12110	COG5016	pyruvate
THIVI_RS12110	COG0511	ligase activity, forming carbon-carbon bonds
THIVI_RS12120	COG4953	penicillin-binding protein 1C
THIVI_RS12125	COG4771	TonB-dependent receptor
THIVI_RS12140	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
THIVI_RS12150	COG0513	Belongs to the DEAD box helicase family
THIVI_RS12155	COG1011	Hydrolase
THIVI_RS12160	COG0494	nUDIX hydrolase
THIVI_RS12170	COG0281	malic enzyme
THIVI_RS12175	COG4536	flavin adenine dinucleotide binding
THIVI_RS12180	COG2974	May be involved in recombination
THIVI_RS12190	COG1070	Carbohydrate kinase
THIVI_RS12205	COG1121	(ABC) transporter
THIVI_RS12210	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
THIVI_RS12225	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
THIVI_RS12255	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
THIVI_RS12265	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THIVI_RS12270	COG4095	Psort location CytoplasmicMembrane, score
THIVI_RS12275	COG0140	phosphoribosyl-ATP diphosphatase activity
THIVI_RS12280	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
THIVI_RS12285	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
THIVI_RS12290	COG0131	Imidazoleglycerol-phosphate dehydratase
THIVI_RS12310	COG0281	malic enzyme
THIVI_RS12310	COG0280	phosphate acetyltransferase
THIVI_RS12315	COG0569	domain protein
THIVI_RS12320	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
THIVI_RS12330	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THIVI_RS12340	COG0261	This protein binds to 23S rRNA in the presence of protein L20
THIVI_RS12345	COG0142	geranyltranstransferase activity
THIVI_RS12370	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
THIVI_RS12400	COG3459	Glycosyltransferase 36 associated
THIVI_RS12405	COG2823	Periplasmic or secreted lipoprotein
THIVI_RS12410	COG2823	Periplasmic or secreted lipoprotein
THIVI_RS12445	COG0840	transmembrane signaling receptor activity
THIVI_RS12480	COG2205	protein histidine kinase activity
THIVI_RS12480	COG0784	Response regulator, receiver
THIVI_RS12530	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
THIVI_RS12535	COG0303	'Molybdopterin
THIVI_RS12540	COG0521	Mo-molybdopterin cofactor biosynthetic process
THIVI_RS12545	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
THIVI_RS12550	COG1047	Peptidyl-prolyl cis-trans
THIVI_RS12555	COG0355	proton-transporting ATP synthase activity, rotational mechanism
THIVI_RS12560	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
THIVI_RS12565	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
THIVI_RS12570	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
THIVI_RS12575	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THIVI_RS12580	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
THIVI_RS12590	COG0356	it plays a direct role in the translocation of protons across the membrane
THIVI_RS12600	COG1475	DNA binding
THIVI_RS12605	COG1192	Involved in chromosome partitioning
THIVI_RS12610	COG0357	Ribosomal RNA small subunit methyltransferase G
THIVI_RS12615	COG0445	tRNA wobble uridine modification
THIVI_RS12620	COG0714	Associated with various cellular activities
THIVI_RS12625	COG5002	protein histidine kinase activity
THIVI_RS12625	COG0784	Response regulator, receiver
THIVI_RS12635	COG0436	Aminotransferase
THIVI_RS12645	COG2171	N-acyltransferase activity
THIVI_RS12650	COG1393	Belongs to the ArsC family
THIVI_RS12655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
THIVI_RS12675	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
THIVI_RS12695	COG0436	Aminotransferase
THIVI_RS12710	COG1131	(ABC) transporter
THIVI_RS12715	COG0842	Transport permease protein
THIVI_RS12740	COG0012	GTP binding
THIVI_RS12750	COG0483	inositol monophosphate 1-phosphatase activity
THIVI_RS12780	COG1484	DNA-dependent DNA replication
THIVI_RS12950	COG0137	argininosuccinate synthase activity
THIVI_RS13035	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
THIVI_RS13035	COG2755	lipolytic protein G-D-S-L family
THIVI_RS13040	COG1216	Glycosyl transferase, family 2
THIVI_RS13040	COG0438	transferase activity, transferring glycosyl groups
THIVI_RS13045	COG1215	transferase activity, transferring glycosyl groups
THIVI_RS13050	COG0702	epimerase
THIVI_RS13075	COG0375	protein maturation
THIVI_RS13085	COG1166	arginine decarboxylase activity
THIVI_RS13095	COG2920	part of a sulfur-relay system
THIVI_RS13115	COG2181	nitrate reductase activity
THIVI_RS13145	COG2223	nitrite transmembrane transporter activity
THIVI_RS13155	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
THIVI_RS13160	COG2894	cell division
THIVI_RS13165	COG0850	regulation of cytokinetic process
THIVI_RS13170	COG0537	adenosine 5'-monophosphoramidase activity
THIVI_RS13175	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
THIVI_RS13180	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
THIVI_RS13185	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THIVI_RS13190	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THIVI_RS13195	COG1278	Cold shock
THIVI_RS13200	COG0756	dUTP diphosphatase activity
THIVI_RS13205	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THIVI_RS13210	COG2003	Belongs to the UPF0758 family
THIVI_RS13215	COG0433	COG0433 Predicted ATPase
THIVI_RS13225	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
THIVI_RS13235	COG1160	GTP binding
THIVI_RS13245	COG2976	Protein conserved in bacteria
THIVI_RS13250	COG0124	histidyl-tRNA synthetase
THIVI_RS13265	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THIVI_RS13270	COG0105	UTP biosynthetic process
THIVI_RS13280	COG2010	Cytochrome c
THIVI_RS13285	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
THIVI_RS13300	COG3086	response to oxidative stress
THIVI_RS13320	COG0446	pyridine nucleotide-disulphide oxidoreductase
THIVI_RS13330	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
THIVI_RS13335	COG0024	Methionine aminopeptidase
THIVI_RS13340	COG0052	Belongs to the universal ribosomal protein uS2 family
THIVI_RS13345	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
THIVI_RS13350	COG0528	UMP kinase activity
THIVI_RS13355	COG0233	cytoplasmic translational termination
THIVI_RS13360	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
THIVI_RS13370	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
THIVI_RS13380	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THIVI_RS13390	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THIVI_RS13395	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THIVI_RS13400	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THIVI_RS13410	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
THIVI_RS13420	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THIVI_RS13445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THIVI_RS13475	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
THIVI_RS13495	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
THIVI_RS13500	COG1053	succinate dehydrogenase
THIVI_RS13505	COG2009	succinate dehydrogenase
THIVI_RS13515	COG2001	Belongs to the MraZ family
THIVI_RS13530	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THIVI_RS13535	COG0693	protein deglycase activity
THIVI_RS13540	COG0793	Belongs to the peptidase S41A family
THIVI_RS13545	COG4942	peptidase
THIVI_RS13555	COG1054	Belongs to the UPF0176 family
THIVI_RS13560	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
THIVI_RS13565	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
THIVI_RS13570	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
THIVI_RS13585	COG2204	response regulator
THIVI_RS13590	COG3852	Histidine kinase
THIVI_RS13600	COG0174	glutamine synthetase
THIVI_RS13620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THIVI_RS13625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THIVI_RS13645	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
THIVI_RS13665	COG3344	reverse transcriptase
THIVI_RS13670	COG2211	Major facilitator Superfamily
THIVI_RS13725	COG1058	Belongs to the CinA family
THIVI_RS13725	COG1546	Belongs to the CinA family
THIVI_RS13735	COG1459	type II secretion system
THIVI_RS13745	COG0751	glycine-tRNA ligase activity
THIVI_RS13750	COG0752	glycyl-tRNA synthetase alpha subunit
THIVI_RS13755	COG3045	CreA protein
THIVI_RS13805	COG0210	DNA helicase
THIVI_RS13810	COG0539	negative regulation of cytoplasmic translation
THIVI_RS13815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THIVI_RS13820	COG0254	rRNA binding
THIVI_RS13825	COG0039	L-malate dehydrogenase activity
THIVI_RS13830	COG0372	Belongs to the citrate synthase family
THIVI_RS13870	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
THIVI_RS13875	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
THIVI_RS13880	COG0067	glutamate synthase
THIVI_RS13880	COG0070	glutamate synthase
THIVI_RS13880	COG0069	glutamate synthase activity
THIVI_RS13905	COG1450	Type ii and iii secretion system protein
THIVI_RS13920	COG3166	PFAM Fimbrial assembly family protein
THIVI_RS13925	COG3156	type II secretion system protein K
THIVI_RS13935	COG2165	general secretion pathway protein
THIVI_RS13960	COG3153	acetyltransferase
THIVI_RS13995	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
THIVI_RS14025	COG1690	Belongs to the RtcB family
THIVI_RS14040	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THIVI_RS14050	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
THIVI_RS14055	COG0390	transport system, permease component
THIVI_RS14060	COG3842	ATPase activity
THIVI_RS14065	COG0220	tRNA (guanine-N7-)-methyltransferase activity
THIVI_RS14070	COG2022	thiamine diphosphate biosynthetic process
THIVI_RS14080	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
THIVI_RS14085	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
THIVI_RS14105	COG0314	molybdopterin synthase activity
THIVI_RS14110	COG0187	DNA topoisomerase II activity
THIVI_RS14120	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THIVI_RS14125	COG0649	NAD binding
THIVI_RS14130	COG0651	ATP synthesis coupled electron transport
THIVI_RS14140	COG0650	Formate hydrogenlyase subunit 4
THIVI_RS14145	COG0651	ATP synthesis coupled electron transport
THIVI_RS14185	COG4245	von Willebrand factor, type A
THIVI_RS14300	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
THIVI_RS14340	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
THIVI_RS14360	COG1320	monovalent cation:proton antiporter activity
THIVI_RS14365	COG2212	antiporter activity
THIVI_RS14375	COG0651	ATP synthesis coupled electron transport
THIVI_RS14380	COG1006	Multisubunit Na H antiporter MnhC subunit
THIVI_RS14385	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THIVI_RS14385	COG2111	Na H antiporter
THIVI_RS14405	COG5433	transposase activity
THIVI_RS14425	COG1376	ErfK ybiS ycfS ynhG family protein
THIVI_RS14430	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THIVI_RS14435	COG3706	GGDEF domain
THIVI_RS14450	COG1999	signal sequence binding
THIVI_RS14485	COG2177	Part of the ABC transporter FtsEX involved in
THIVI_RS14490	COG2884	Cell division ATP-binding protein ftsE
THIVI_RS14495	COG0552	protein localization to endoplasmic reticulum
THIVI_RS14515	COG1253	flavin adenine dinucleotide binding
THIVI_RS14520	COG1215	transferase activity, transferring glycosyl groups
THIVI_RS14535	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
THIVI_RS14540	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
THIVI_RS14550	COG0742	ribosomal rna small subunit methyltransferase
THIVI_RS14555	COG0612	Peptidase, M16
THIVI_RS14560	COG0612	Peptidase, M16
THIVI_RS14575	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THIVI_RS14580	COG0167	dihydroorotate dehydrogenase activity
THIVI_RS14590	COG0706	membrane insertase activity
THIVI_RS14595	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THIVI_RS14630	COG5433	transposase activity
THIVI_RS14700	COG1741	Belongs to the pirin family
THIVI_RS14705	COG1028	Short-chain dehydrogenase reductase Sdr
THIVI_RS14730	COG3273	potassium ion transport
THIVI_RS14730	COG0471	metal ion transport
THIVI_RS14740	COG5001	Diguanylate cyclase
THIVI_RS14740	COG3300	MHYT domain
THIVI_RS14745	COG0717	Belongs to the dCTP deaminase family
THIVI_RS14760	COG0438	transferase activity, transferring glycosyl groups
THIVI_RS14775	COG0573	inorganic phosphate transmembrane transporter activity
THIVI_RS14785	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THIVI_RS14800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THIVI_RS14805	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THIVI_RS14805	COG0574	Belongs to the PEP-utilizing enzyme family
THIVI_RS14815	COG1215	transferase activity, transferring glycosyl groups
THIVI_RS14835	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
THIVI_RS14850	COG4133	protoheme IX ABC transporter activity
THIVI_RS14860	COG4235	cytochrome complex assembly
THIVI_RS14860	COG3088	subunit of a heme lyase
THIVI_RS14865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THIVI_RS14875	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
THIVI_RS14880	COG2135	peptidase activity
THIVI_RS14895	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
THIVI_RS14915	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
THIVI_RS14920	COG0352	thiamine-phosphate diphosphorylase activity
THIVI_RS14925	COG0351	phosphomethylpyrimidine kinase
THIVI_RS14930	COG1773	rubredoxin
THIVI_RS14945	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
THIVI_RS14950	COG0316	Belongs to the HesB IscA family
THIVI_RS14960	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
THIVI_RS14970	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
THIVI_RS14975	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THIVI_RS14990	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THIVI_RS15060	COG0419	ATPase involved in DNA repair
THIVI_RS15070	COG2048	Heterodisulfide reductase, subunit B
THIVI_RS15085	COG1233	COG1233 Phytoene dehydrogenase and related
THIVI_RS15090	COG1793	dna ligase
THIVI_RS15095	COG0500	methyltransferase
THIVI_RS15115	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THIVI_RS15120	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
THIVI_RS15125	COG3959	Transketolase, thiamine diphosphate binding domain
THIVI_RS15130	COG3958	Transketolase
THIVI_RS15140	COG1850	ribulose-bisphosphate carboxylase activity
THIVI_RS15145	COG1862	Preprotein translocase
THIVI_RS15150	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THIVI_RS15155	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THIVI_RS15175	COG4181	ATPase activity
THIVI_RS15180	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
THIVI_RS15195	COG3864	Putative metallopeptidase domain
THIVI_RS15200	COG4783	chaperone-mediated protein folding
THIVI_RS15265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THIVI_RS15295	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
THIVI_RS15300	COG1169	isochorismate synthase
THIVI_RS15310	COG0702	epimerase
THIVI_RS15325	COG1472	Belongs to the glycosyl hydrolase 3 family
THIVI_RS15330	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
THIVI_RS15350	COG0779	Required for maturation of 30S ribosomal subunits
THIVI_RS15355	COG0195	Participates in both transcription termination and antitermination
THIVI_RS15360	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
THIVI_RS15365	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
THIVI_RS15370	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
THIVI_RS15375	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
THIVI_RS15380	COG1185	polyribonucleotide nucleotidyltransferase activity
THIVI_RS15385	COG1177	transmembrane transport
THIVI_RS15390	COG1176	ABC-type spermidine putrescine transport system, permease component I
THIVI_RS15395	COG3842	ATPase activity
THIVI_RS15400	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
THIVI_RS15415	COG2878	Part of a membrane complex involved in electron transport
THIVI_RS15415	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
THIVI_RS15420	COG0674	pyruvate-flavodoxin oxidoreductase activity
THIVI_RS15420	COG1013	pyruvate-flavodoxin oxidoreductase activity
THIVI_RS15420	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THIVI_RS15420	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
THIVI_RS15425	COG4656	Part of a membrane complex involved in electron transport
THIVI_RS15430	COG4658	electron transport chain
THIVI_RS15435	COG4659	FMN binding
THIVI_RS15440	COG4660	Part of a membrane complex involved in electron transport
THIVI_RS15445	COG4657	Part of a membrane complex involved in electron transport
THIVI_RS15455	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
THIVI_RS15460	COG0488	(ABC) transporter
THIVI_RS15475	COG1763	Mo-molybdopterin cofactor biosynthetic process
THIVI_RS15480	COG0569	domain protein
THIVI_RS15485	COG2204	response regulator
THIVI_RS15490	COG5000	phosphorelay sensor kinase activity
THIVI_RS15505	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THIVI_RS15510	COG0242	peptide deformylase activity
THIVI_RS15520	COG0758	DNA mediated transformation
THIVI_RS15525	COG2922	Belongs to the Smg family
THIVI_RS15540	COG0009	L-threonylcarbamoyladenylate synthase
THIVI_RS15545	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
THIVI_RS15580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THIVI_RS15585	COG0471	metal ion transport
THIVI_RS15585	COG3273	potassium ion transport
THIVI_RS15605	COG0189	ligase activity
THIVI_RS15610	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
THIVI_RS15625	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
THIVI_RS15635	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THIVI_RS15640	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
THIVI_RS15650	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
THIVI_RS15655	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THIVI_RS15670	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
THIVI_RS15675	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
THIVI_RS15680	COG1127	ABC transporter
THIVI_RS15685	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
THIVI_RS15705	COG1802	Transcriptional regulator
THIVI_RS15765	COG4251	negative regulation of phosphorylation
THIVI_RS15775	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
THIVI_RS15790	COG3527	Alpha-acetolactate decarboxylase
THIVI_RS15820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THIVI_RS15825	COG0735	belongs to the Fur family
THIVI_RS15840	COG1028	Short-chain dehydrogenase reductase Sdr
THIVI_RS15855	COG0227	Belongs to the bacterial ribosomal protein bL28 family
THIVI_RS15860	COG0267	Belongs to the bacterial ribosomal protein bL33 family
THIVI_RS15885	COG0297	glycogen (starch) synthase activity
THIVI_RS15890	COG0443	Heat shock 70 kDa protein
THIVI_RS15910	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THIVI_RS15925	COG0316	Belongs to the HesB IscA family
THIVI_RS15930	COG2166	iron-sulfur cluster assembly
THIVI_RS15935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
THIVI_RS15955	COG4589	Belongs to the CDS family
THIVI_RS15995	COG2363	Small membrane protein
THIVI_RS16000	COG1385	rRNA (uridine-N3-)-methyltransferase activity
THIVI_RS16005	COG0643	Histidine kinase
THIVI_RS16005	COG0784	Response regulator, receiver
THIVI_RS16005	COG2198	Histidine kinase
THIVI_RS16010	COG0840	transmembrane signaling receptor activity
THIVI_RS16030	COG0189	ligase activity
THIVI_RS16045	COG1678	Uncharacterized ACR, COG1678
THIVI_RS16050	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
THIVI_RS16060	COG0540	Belongs to the ATCase OTCase family
THIVI_RS16085	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
THIVI_RS16090	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
THIVI_RS16100	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THIVI_RS16110	COG0194	GDP metabolic process
THIVI_RS16115	COG1561	YicC-like family, N-terminal region
THIVI_RS16120	COG0515	serine threonine protein kinase
THIVI_RS16120	COG3266	domain, Protein
THIVI_RS16125	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
THIVI_RS16130	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
THIVI_RS16150	COG1872	DUF167
THIVI_RS16160	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
THIVI_RS16170	COG3562	capsule polysaccharide
THIVI_RS16200	COG0402	S-adenosylhomocysteine deaminase activity
THIVI_RS16205	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
THIVI_RS16215	COG0196	riboflavin kinase activity
THIVI_RS16225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
THIVI_RS16235	COG1199	ATP-dependent helicase activity
THIVI_RS16240	COG0450	alkyl hydroperoxide reductase
THIVI_RS16245	COG1643	Atp-dependent helicase
THIVI_RS16255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THIVI_RS16255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THIVI_RS16275	COG0045	succinate-CoA ligase (ADP-forming) activity
THIVI_RS16280	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
THIVI_RS16290	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THIVI_RS16290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THIVI_RS16315	COG3830	Belongs to the UPF0237 family
THIVI_RS16320	COG0242	peptide deformylase activity
THIVI_RS16325	COG0793	Belongs to the peptidase S41A family
THIVI_RS16330	COG2918	glutathione biosynthetic process
THIVI_RS16340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THIVI_RS16350	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THIVI_RS16355	COG0741	lytic transglycosylase activity
THIVI_RS16375	COG0218	Necessary for normal cell division and for the maintenance of normal septation
THIVI_RS16380	COG0315	cyclic pyranopterin monophosphate synthase activity
THIVI_RS16385	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
THIVI_RS16395	COG0205	6-phosphofructokinase activity
THIVI_RS16405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
THIVI_RS16410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
THIVI_RS16415	COG0006	proline dipeptidase activity
THIVI_RS16420	COG3079	Belongs to the UPF0149 family
THIVI_RS16435	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
THIVI_RS16440	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
THIVI_RS16455	COG4657	Part of a membrane complex involved in electron transport
THIVI_RS16460	COG2878	Part of a membrane complex involved in electron transport
THIVI_RS16465	COG4656	Part of a membrane complex involved in electron transport
THIVI_RS16470	COG4658	electron transport chain
THIVI_RS16485	COG2914	Belongs to the UPF0125 (RnfH) family
THIVI_RS16495	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
THIVI_RS16495	COG0116	Belongs to the methyltransferase superfamily
THIVI_RS16505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THIVI_RS16510	COG0205	6-phosphofructokinase activity
THIVI_RS16515	COG0508	dehydrogenase complex catalyzes the overall conversion of
THIVI_RS16530	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
THIVI_RS16560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THIVI_RS16565	COG2816	NAD+ diphosphatase activity
THIVI_RS16615	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THIVI_RS16625	COG1716	ATPase activity
THIVI_RS16655	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THIVI_RS16660	COG1028	Short-chain dehydrogenase reductase Sdr
THIVI_RS16685	COG3243	poly(R)-hydroxyalkanoic acid synthase
THIVI_RS16700	COG0811	peptide transport
THIVI_RS16705	COG0848	biopolymer transport protein
THIVI_RS16710	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
THIVI_RS16725	COG4206	TonB-dependent receptor
THIVI_RS16735	COG4149	molybdate abc transporter
THIVI_RS16740	COG3842	ATPase activity
THIVI_RS16785	COG0058	SHG alpha-glucan phosphorylase activity
THIVI_RS16800	COG0488	(ABC) transporter
THIVI_RS16805	COG0606	chelatase, subunit chli
THIVI_RS16810	COG2960	long-chain fatty acid transporting porin activity
THIVI_RS16820	COG0347	Belongs to the P(II) protein family
THIVI_RS16825	COG0004	ammonium transporteR
THIVI_RS16830	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THIVI_RS16845	COG0408	coproporphyrinogen oxidase activity
THIVI_RS16855	COG0667	Aldo Keto reductase
THIVI_RS16860	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
THIVI_RS16865	COG0546	phosphoglycolate phosphatase activity
THIVI_RS16895	COG1301	dicarboxylic acid transport
THIVI_RS16910	COG2207	Transcriptional regulator
THIVI_RS16935	COG2863	cytochrome
THIVI_RS16945	COG0525	valine-tRNA ligase activity
THIVI_RS16950	COG4804	nuclease activity
THIVI_RS17055	COG4373	Mu-like prophage FluMu protein gp28
THIVI_RS17160	COG1196	nuclear chromosome segregation
THIVI_RS17160	COG0741	lytic transglycosylase activity
THIVI_RS17160	COG0739	heme binding
THIVI_RS17185	COG5433	transposase activity
THIVI_RS17210	COG5433	transposase activity
THIVI_RS17220	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
THIVI_RS17225	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
THIVI_RS17235	COG3038	cytochrome b561
THIVI_RS17240	COG0598	Magnesium transport protein CorA
THIVI_RS17285	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
THIVI_RS17300	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THIVI_RS17305	COG4106	trans-aconitate 2-methyltransferase activity
THIVI_RS17310	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
THIVI_RS17320	COG0248	Ppx GppA phosphatase
THIVI_RS17330	COG1511	domain protein
THIVI_RS17330	COG3264	Mechanosensitive ion channel
THIVI_RS17345	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
THIVI_RS17360	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THIVI_RS17370	COG5433	transposase activity
THIVI_RS17405	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THIVI_RS17410	COG0134	indole-3-glycerol-phosphate synthase activity
THIVI_RS17420	COG1765	OsmC-like protein
THIVI_RS17425	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
THIVI_RS17430	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
THIVI_RS17435	COG0247	lactate metabolic process
THIVI_RS17445	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
THIVI_RS17465	COG2801	Transposase and inactivated derivatives
THIVI_RS17475	COG0513	Belongs to the DEAD box helicase family
THIVI_RS17480	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
THIVI_RS17485	COG5433	transposase activity
THIVI_RS17510	COG1690	Belongs to the RtcB family
THIVI_RS17515	COG0815	Transfers the fatty acyl group on membrane lipoproteins
THIVI_RS17525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THIVI_RS17535	COG0204	Acyl-transferase
THIVI_RS17535	COG0318	PFAM AMP-dependent synthetase and ligase
THIVI_RS17545	COG0494	nUDIX hydrolase
THIVI_RS17550	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
THIVI_RS17565	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
THIVI_RS17660	COG0582	viral genome integration into host DNA
THIVI_RS17675	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
THIVI_RS17695	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
THIVI_RS17725	COG0058	SHG alpha-glucan phosphorylase activity
THIVI_RS17735	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
THIVI_RS17740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THIVI_RS17745	COG0628	permease
THIVI_RS17810	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
THIVI_RS17815	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
THIVI_RS17830	COG0438	transferase activity, transferring glycosyl groups
THIVI_RS17850	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
THIVI_RS17850	COG0551	DNA topoisomerase type I activity
THIVI_RS17870	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THIVI_RS17885	COG2205	protein histidine kinase activity
THIVI_RS17885	COG0784	Response regulator, receiver
THIVI_RS17885	COG2198	Histidine kinase
THIVI_RS17905	COG2813	Specifically methylates the guanine in position
THIVI_RS17910	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
THIVI_RS17915	COG0298	carbon dioxide binding
THIVI_RS17945	COG0583	DNA-binding transcription factor activity
THIVI_RS17970	COG0586	Pfam SNARE associated Golgi protein
THIVI_RS17995	COG5433	transposase activity
THIVI_RS18010	COG5433	transposase activity
THIVI_RS18040	COG4974	Belongs to the 'phage' integrase family
THIVI_RS18045	COG1666	GTP binding
THIVI_RS18050	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
THIVI_RS18055	COG0631	protein serine/threonine phosphatase activity
THIVI_RS18075	COG5433	transposase activity
THIVI_RS18085	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THIVI_RS18110	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
THIVI_RS18115	COG0723	plastoquinol--plastocyanin reductase activity
THIVI_RS18120	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
THIVI_RS18125	COG2857	Cytochrome c1
THIVI_RS18130	COG0625	glutathione transferase activity
THIVI_RS18135	COG2969	positive regulation of protein catabolic process
THIVI_RS18145	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
THIVI_RS18160	COG1022	Amp-dependent synthetase and ligase
THIVI_RS18170	COG0513	Belongs to the DEAD box helicase family
THIVI_RS18195	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
THIVI_RS18215	COG1523	belongs to the glycosyl hydrolase 13 family
THIVI_RS18225	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
THIVI_RS18250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THIVI_RS18255	COG1573	uracil-dna glycosylase
THIVI_RS18290	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THIVI_RS18310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THIVI_RS18340	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
THIVI_RS18350	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
THIVI_RS18360	COG0018	arginyl-trna synthetase
THIVI_RS18365	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THIVI_RS18375	COG3001	Fructosamine kinase
THIVI_RS18415	COG0811	peptide transport
THIVI_RS18420	COG0848	biopolymer transport protein
THIVI_RS18425	COG1132	(ABC) transporter
THIVI_RS18430	COG1663	tetraacyldisaccharide 4'-kinase activity
THIVI_RS18435	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
THIVI_RS18440	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
THIVI_RS18445	COG3162	membrane
THIVI_RS18450	COG0167	dihydroorotate dehydrogenase activity
THIVI_RS18455	COG0674	pyruvate-flavodoxin oxidoreductase activity
THIVI_RS18455	COG1013	pyruvate-flavodoxin oxidoreductase activity
THIVI_RS18455	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THIVI_RS18455	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
THIVI_RS18460	COG0456	acetyltransferase
THIVI_RS18480	COG1151	hydroxylamine reductase activity
THIVI_RS18495	COG2133	pyrroloquinoline quinone binding
THIVI_RS18510	COG0154	amidase activity
THIVI_RS18515	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THIVI_RS18520	COG1077	Cell shape determining protein MreB Mrl
THIVI_RS18525	COG1792	Involved in formation and maintenance of cell shape
THIVI_RS18535	COG0768	penicillin binding
THIVI_RS18540	COG0772	Belongs to the SEDS family
THIVI_RS18545	COG2951	lytic endotransglycosylase activity
THIVI_RS18555	COG1686	Belongs to the peptidase S11 family
THIVI_RS18560	COG2921	Belongs to the UPF0250 family
THIVI_RS18565	COG0321	lipoyl(octanoyl) transferase activity
THIVI_RS18590	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THIVI_RS18600	COG0343	queuine tRNA-ribosyltransferase activity
THIVI_RS18605	COG0071	Belongs to the small heat shock protein (HSP20) family
THIVI_RS18610	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
THIVI_RS18615	COG4221	oxidoreductase activity
THIVI_RS18615	COG0604	alcohol dehydrogenase
THIVI_RS18615	COG3321	synthase
THIVI_RS18615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
THIVI_RS18625	COG0037	tRNA processing
THIVI_RS18650	COG0567	Dehydrogenase, E1 component
THIVI_RS18685	COG0339	signal peptide processing
THIVI_RS18695	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
THIVI_RS18700	COG0724	RNA recognition motif
THIVI_RS18715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THIVI_RS18720	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
THIVI_RS18720	COG0543	2 iron, 2 sulfur cluster binding
THIVI_RS18780	COG1587	Uroporphyrinogen-III synthase
THIVI_RS18785	COG0181	hydroxymethylbilane synthase activity
THIVI_RS18810	COG5433	transposase activity
THIVI_RS18840	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
THIVI_RS18845	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
THIVI_RS18850	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
THIVI_RS18860	COG1752	Esterase of the alpha-beta hydrolase superfamily
THIVI_RS18885	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
THIVI_RS18890	COG0149	triose-phosphate isomerase activity
THIVI_RS18905	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THIVI_RS18910	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THIVI_RS18915	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THIVI_RS18920	COG0649	NAD binding
THIVI_RS18925	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
THIVI_RS18935	COG1034	ATP synthesis coupled electron transport
THIVI_RS18935	COG1034	ATP synthesis coupled electron transport
THIVI_RS18940	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
THIVI_RS18945	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THIVI_RS18955	COG0713	ATP synthesis coupled electron transport
THIVI_RS18970	COG1007	ATP synthesis coupled electron transport
THIVI_RS18975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THIVI_RS18980	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
THIVI_RS19010	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
THIVI_RS19020	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
THIVI_RS19025	COG0437	4 iron, 4 sulfur cluster binding
THIVI_RS19030	COG5557	Pfam Polysulphide reductase, NrfD
THIVI_RS19035	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
THIVI_RS19040	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
THIVI_RS19080	COG2204	response regulator
THIVI_RS19110	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
THIVI_RS19155	COG3034	peptidoglycan biosynthetic process
THIVI_RS19160	COG1388	LysM domain
THIVI_RS19160	COG0741	lytic transglycosylase activity
THIVI_RS19170	COG0328	RNA-DNA hybrid ribonuclease activity
THIVI_RS19175	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
THIVI_RS19180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THIVI_RS19185	COG0504	CTP synthase activity
THIVI_RS19190	COG2877	3-deoxy-8-phosphooctulonate synthase activity
THIVI_RS19210	COG0148	phosphopyruvate hydratase activity
THIVI_RS19215	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
THIVI_RS19220	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
THIVI_RS19250	COG0529	Catalyzes the synthesis of activated sulfate
THIVI_RS19255	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
THIVI_RS19275	COG1269	ATP hydrolysis coupled proton transport
THIVI_RS19290	COG3437	response regulator, receiver
THIVI_RS19290	COG2205	protein histidine kinase activity
THIVI_RS19290	COG3850	Histidine kinase
THIVI_RS19290	COG4999	Histidine kinase
THIVI_RS19305	COG0259	pyridoxamine-phosphate oxidase activity
THIVI_RS19310	COG2224	Isocitrate lyase
THIVI_RS19315	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
THIVI_RS19320	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
THIVI_RS19325	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
THIVI_RS19325	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THIVI_RS19330	COG0802	atpase or kinase
THIVI_RS19335	COG0860	N-Acetylmuramoyl-L-alanine amidase
THIVI_RS19340	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
THIVI_RS19345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THIVI_RS19350	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
THIVI_RS19360	COG0436	Aminotransferase
THIVI_RS19375	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
THIVI_RS19385	COG0142	geranyltranstransferase activity
THIVI_RS19400	COG1469	GTP cyclohydrolase I activity
THIVI_RS19420	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
THIVI_RS19500	COG0297	glycogen (starch) synthase activity
THIVI_RS19580	COG1216	Glycosyl transferase, family 2
THIVI_RS19615	COG1216	Glycosyl transferase, family 2
THIVI_RS19635	COG0438	transferase activity, transferring glycosyl groups
THIVI_RS19655	COG1162	GTPase activity
THIVI_RS19665	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
THIVI_RS19700	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THIVI_RS19715	COG0828	Belongs to the bacterial ribosomal protein bS21 family
THIVI_RS19720	COG1610	YqeY-like protein
THIVI_RS19750	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
THIVI_RS19750	COG2308	Evidence 4 Homologs of previously reported genes of
THIVI_RS19760	COG1752	Esterase of the alpha-beta hydrolase superfamily
THIVI_RS19805	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
THIVI_RS19810	COG0424	maF-like protein
THIVI_RS19825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THIVI_RS19830	COG0312	modulator of DNA gyrase
THIVI_RS19835	COG1061	Type III restriction enzyme res subunit
THIVI_RS19850	COG2197	response regulator
THIVI_RS19885	COG0643	Histidine kinase
THIVI_RS19885	COG2198	Histidine kinase
THIVI_RS19895	COG0835	chemotaxis
THIVI_RS19905	COG0835	chemotaxis
THIVI_RS19915	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
THIVI_RS19925	COG5001	Diguanylate cyclase
THIVI_RS19925	COG3300	MHYT domain
THIVI_RS19930	COG0312	modulator of DNA gyrase
THIVI_RS19945	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
THIVI_RS19950	COG0076	glutamate decarboxylase activity
THIVI_RS20000	COG0312	modulator of DNA gyrase
THIVI_RS20025	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
THIVI_RS20035	COG5001	Diguanylate cyclase
THIVI_RS20035	COG3300	MHYT domain
THIVI_RS20040	COG1639	'signal transduction protein
THIVI_RS20050	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
THIVI_RS20065	COG2951	lytic endotransglycosylase activity
THIVI_RS20070	COG0432	Pfam Uncharacterised protein family UPF0047
THIVI_RS20075	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THIVI_RS20080	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
THIVI_RS20110	COG3437	response regulator, receiver
THIVI_RS20120	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
THIVI_RS20160	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
THIVI_RS20165	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
THIVI_RS20175	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
THIVI_RS20185	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
THIVI_RS20190	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
THIVI_RS20195	COG0193	aminoacyl-tRNA hydrolase activity
THIVI_RS20225	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THIVI_RS20245	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
THIVI_RS20250	COG0081	regulation of translation
THIVI_RS20255	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
THIVI_RS20260	COG0222	ribosome binding
THIVI_RS20265	COG0085	RNA polymerase activity
THIVI_RS20270	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
THIVI_RS20275	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
THIVI_RS20280	COG0049	tRNA binding
THIVI_RS20285	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THIVI_RS20290	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THIVI_RS20295	COG0051	transcription antitermination factor activity, RNA binding
THIVI_RS20300	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
THIVI_RS20305	COG0088	Forms part of the polypeptide exit tunnel
THIVI_RS20310	COG0089	rRNA binding
THIVI_RS20315	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
THIVI_RS20320	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
THIVI_RS20325	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
THIVI_RS20330	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
THIVI_RS20335	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
THIVI_RS20340	COG0255	Belongs to the universal ribosomal protein uL29 family
THIVI_RS20345	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
THIVI_RS20350	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
THIVI_RS20355	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
THIVI_RS20360	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
THIVI_RS20365	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
THIVI_RS20375	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
THIVI_RS20380	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
THIVI_RS20385	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
THIVI_RS20390	COG1841	ribosomal large subunit assembly
THIVI_RS20395	COG0200	Binds to the 23S rRNA
THIVI_RS20400	COG0201	protein transport
THIVI_RS20405	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
THIVI_RS20410	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
THIVI_RS20415	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
THIVI_RS20420	COG0202	RNA polymerase activity
THIVI_RS20425	COG0203	ribosomal protein L17
THIVI_RS20450	COG0617	tRNA 3'-terminal CCA addition
THIVI_RS20480	COG1850	ribulose-bisphosphate carboxylase activity
THIVI_RS20485	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
THIVI_RS20490	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
THIVI_RS20505	COG0348	domain, Protein
THIVI_RS20510	COG0437	4 iron, 4 sulfur cluster binding
THIVI_RS20515	COG0243	molybdopterin cofactor binding
THIVI_RS20530	COG3850	Histidine kinase
THIVI_RS20535	COG2197	response regulator
THIVI_RS20540	COG0367	asparagine synthase
THIVI_RS20570	COG0489	protein tyrosine kinase activity
THIVI_RS20580	COG1596	polysaccharide export
THIVI_RS20585	COG2204	response regulator
THIVI_RS20640	COG5433	transposase activity
THIVI_RS20650	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
THIVI_RS20680	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
THIVI_RS20700	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
THIVI_RS20705	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
THIVI_RS20760	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
THIVI_RS20765	COG1187	pseudouridine synthase activity
THIVI_RS20780	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
THIVI_RS20785	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
THIVI_RS20795	COG1674	ftsk spoiiie
THIVI_RS20800	COG5002	protein histidine kinase activity
THIVI_RS20810	COG1278	Cold shock
THIVI_RS20825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THIVI_RS20840	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
THIVI_RS20850	COG4636	protein conserved in cyanobacteria
THIVI_RS20865	COG0228	four-way junction DNA binding
THIVI_RS20870	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
THIVI_RS20875	COG0336	Belongs to the RNA methyltransferase TrmD family
THIVI_RS20880	COG0335	large ribosomal subunit rRNA binding
THIVI_RS20885	COG2925	Exonuclease
THIVI_RS20890	COG1720	tRNA m6t6A37 methyltransferase activity
THIVI_RS20895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THIVI_RS20905	COG2954	triphosphatase activity
THIVI_RS20910	COG1376	ErfK ybiS ycfS ynhG family protein
THIVI_RS20915	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
THIVI_RS20920	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
THIVI_RS20925	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
THIVI_RS20980	COG3077	Addiction module antitoxin, RelB DinJ family
THIVI_RS20990	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
THIVI_RS21000	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
THIVI_RS21010	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
THIVI_RS21020	COG1053	succinate dehydrogenase
THIVI_RS21025	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
THIVI_RS21080	COG0189	ligase activity
THIVI_RS21080	COG4067	protein conserved in archaea
THIVI_RS21100	COG0322	excinuclease ABC activity
THIVI_RS21155	COG2801	Transposase and inactivated derivatives
THIVI_RS21250	COG0776	regulation of translation
THIVI_RS21360	COG2369	cell adhesion
THIVI_RS21495	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
THIVI_RS21500	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
THIVI_RS21525	COG3852	Histidine kinase
THIVI_RS21600	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
THIVI_RS21600	COG1017	nitric oxide dioxygenase activity
THIVI_RS21640	COG1444	tRNA N-acetyltransferase activity
THIVI_RS21645	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THIVI_RS21655	COG0446	pyridine nucleotide-disulphide oxidoreductase
THIVI_RS21660	COG2863	cytochrome
THIVI_RS21670	COG3005	denitrification pathway
THIVI_RS21685	COG0297	glycogen (starch) synthase activity
THIVI_RS21690	COG1196	nuclear chromosome segregation
THIVI_RS21700	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THIVI_RS21740	COG2723	6-phospho-beta-galactosidase activity
THIVI_RS21745	COG4178	(ABC) transporter
THIVI_RS21755	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
THIVI_RS21780	COG3706	GGDEF domain
THIVI_RS21800	COG5433	transposase activity
THIVI_RS21805	COG5433	transposase activity
THIVI_RS21825	COG4636	protein conserved in cyanobacteria
THIVI_RS21885	COG3132	Protein of unknown function, DUF480
THIVI_RS21890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THIVI_RS21895	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
THIVI_RS21905	COG0243	molybdopterin cofactor binding
THIVI_RS21910	COG0437	4 iron, 4 sulfur cluster binding
THIVI_RS21915	COG3302	dmso reductase anchor subunit
THIVI_RS21965	COG2915	High frequency lysogenization protein hflD homolog
THIVI_RS21970	COG0482	sulfurtransferase activity
THIVI_RS21985	COG1355	regulation of microtubule-based process
THIVI_RS22000	COG0741	lytic transglycosylase activity
THIVI_RS22010	COG2337	Toxic component of a toxin-antitoxin (TA) module
THIVI_RS22020	COG0730	response to heat
THIVI_RS22035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THIVI_RS22040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THIVI_RS22045	COG2226	methyltransferase
THIVI_RS22075	COG0651	ATP synthesis coupled electron transport
THIVI_RS22085	COG3038	cytochrome b561
THIVI_RS22090	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THIVI_RS22105	COG1278	Cold shock
THIVI_RS22110	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
THIVI_RS22115	COG0542	response to heat
THIVI_RS22140	COG0837	glucose binding
THIVI_RS22145	COG2608	mercury ion transmembrane transporter activity
THIVI_RS22150	COG0729	surface antigen
THIVI_RS22160	COG1560	Kdo2-lipid A biosynthetic process
THIVI_RS22185	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THIVI_RS22200	COG0497	DNA recombination
THIVI_RS22205	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
THIVI_RS22210	COG1420	regulation of RNA biosynthetic process
THIVI_RS22215	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THIVI_RS22220	COG0443	Heat shock 70 kDa protein
THIVI_RS22225	COG0484	heat shock protein binding
THIVI_RS22230	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
THIVI_RS22245	COG1858	cytochrome C peroxidase
THIVI_RS22260	COG2856	Zn peptidase
THIVI_RS22275	COG1061	Type III restriction enzyme res subunit
THIVI_RS22320	COG0582	viral genome integration into host DNA
THIVI_RS22325	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
THIVI_RS22330	COG0424	maF-like protein
THIVI_RS22340	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
THIVI_RS22365	COG0420	3'-5' exonuclease activity
THIVI_RS22370	COG4717	serine-type aminopeptidase activity
THIVI_RS22380	COG1399	metal-binding, possibly nucleic acid-binding protein
THIVI_RS22395	COG3706	GGDEF domain
THIVI_RS22430	COG5002	protein histidine kinase activity
THIVI_RS22460	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
THIVI_RS22490	COG2205	protein histidine kinase activity
THIVI_RS22490	COG3850	Histidine kinase
THIVI_RS22490	COG4999	Histidine kinase
THIVI_RS22490	COG3437	response regulator, receiver
THIVI_RS22510	COG0457	Tetratricopeptide repeat
THIVI_RS22510	COG0515	serine threonine protein kinase
THIVI_RS22545	COG5002	protein histidine kinase activity
THIVI_RS22545	COG0784	Response regulator, receiver
THIVI_RS22545	COG2205	protein histidine kinase activity
THIVI_RS22605	COG2200	EAL domain
THIVI_RS22610	COG1201	RNA secondary structure unwinding
THIVI_RS22615	COG0582	viral genome integration into host DNA
THIVI_RS22640	COG0739	heme binding
THIVI_RS22685	COG3850	Histidine kinase
THIVI_RS22685	COG3437	response regulator, receiver
THIVI_RS22685	COG2205	protein histidine kinase activity
THIVI_RS22685	COG4999	Histidine kinase
THIVI_RS22690	COG5002	protein histidine kinase activity
THIVI_RS22690	COG2205	protein histidine kinase activity
THIVI_RS22690	COG0784	Response regulator, receiver
THIVI_RS22740	COG0515	serine threonine protein kinase
THIVI_RS22740	COG2815	serine threonine protein kinase
THIVI_RS22750	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
THIVI_RS22750	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
THIVI_RS22755	COG4251	negative regulation of phosphorylation
THIVI_RS22760	COG0741	lytic transglycosylase activity
THIVI_RS22785	COG4251	negative regulation of phosphorylation
THIVI_RS22800	COG2205	protein histidine kinase activity
THIVI_RS22800	COG2198	Histidine kinase
THIVI_RS22800	COG0784	Response regulator, receiver
THIVI_RS22805	COG0840	transmembrane signaling receptor activity
THIVI_RS22830	COG1484	DNA-dependent DNA replication
THIVI_RS22840	COG4584	PFAM Integrase catalytic
THIVI_RS22845	COG0438	transferase activity, transferring glycosyl groups
THIVI_RS22845	COG1216	Glycosyl transferase, family 2
THIVI_RS22855	COG1716	ATPase activity
THIVI_RS22855	COG0842	Transport permease protein
THIVI_RS22855	COG1131	(ABC) transporter
THIVI_RS22880	COG3385	transposase activity
THIVI_RS22890	COG2205	protein histidine kinase activity
THIVI_RS22890	COG0745	RESPONSE REGULATOR receiver
THIVI_RS22890	COG4191	Histidine kinase
THIVI_RS22935	COG1484	DNA-dependent DNA replication
THIVI_RS22950	COG2815	serine threonine protein kinase
THIVI_RS22950	COG0515	serine threonine protein kinase
THIVI_RS22975	COG5005	Phage virion morphogenesis
THIVI_RS23030	COG0784	Response regulator, receiver
THIVI_RS23030	COG2205	protein histidine kinase activity
THIVI_RS23030	COG5002	protein histidine kinase activity
THIVI_RS23035	COG0737	Belongs to the 5'-nucleotidase family
THIVI_RS23050	COG3258	Cytochrome c
THIVI_RS23055	COG4999	Histidine kinase
THIVI_RS23055	COG3850	Histidine kinase
THIVI_RS23055	COG2205	protein histidine kinase activity
THIVI_RS23055	COG3437	response regulator, receiver
THIVI_RS23070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THIVI_RS23080	COG3267	Type II secretory pathway component ExeA
THIVI_RS23080	COG3409	Peptidoglycan-binding domain 1 protein
THIVI_RS23115	COG3646	Phage regulatory protein
THIVI_RS23145	COG0515	serine threonine protein kinase
THIVI_RS23145	COG2815	serine threonine protein kinase