locus-tag	class	description
THIMO_RS00015	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THIMO_RS00020	COG0592	DNA-directed DNA polymerase activity
THIMO_RS00030	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THIMO_RS00035	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
THIMO_RS00045	COG2433	Pfam Transposase IS66
THIMO_RS00075	COG0463	Glycosyl transferase, family 2
THIMO_RS00120	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THIMO_RS00175	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THIMO_RS00185	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
THIMO_RS00190	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
THIMO_RS00195	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THIMO_RS00200	COG1459	type II secretion system
THIMO_RS00210	COG4970	Tfp pilus assembly protein FimT
THIMO_RS00215	COG2165	general secretion pathway protein
THIMO_RS00225	COG3156	type II secretion system protein K
THIMO_RS00230	COG3166	PFAM Fimbrial assembly family protein
THIMO_RS00245	COG1450	Type ii and iii secretion system protein
THIMO_RS00250	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
THIMO_RS00260	COG2226	methyltransferase
THIMO_RS00265	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THIMO_RS00275	COG0815	Transfers the fatty acyl group on membrane lipoproteins
THIMO_RS00290	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THIMO_RS00300	COG3179	chitinase
THIMO_RS00320	COG0586	Pfam SNARE associated Golgi protein
THIMO_RS00325	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
THIMO_RS00330	COG0352	thiamine-phosphate diphosphorylase activity
THIMO_RS00335	COG0351	phosphomethylpyrimidine kinase
THIMO_RS00335	COG0352	thiamine-phosphate diphosphorylase activity
THIMO_RS00340	COG1773	rubredoxin
THIMO_RS00350	COG0316	Belongs to the HesB IscA family
THIMO_RS00355	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
THIMO_RS00360	COG0210	DNA helicase
THIMO_RS00365	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
THIMO_RS00370	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THIMO_RS00375	COG0254	rRNA binding
THIMO_RS00380	COG0372	Belongs to the citrate synthase family
THIMO_RS00415	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
THIMO_RS00420	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
THIMO_RS00425	COG0070	glutamate synthase
THIMO_RS00425	COG0067	glutamate synthase
THIMO_RS00425	COG0069	glutamate synthase activity
THIMO_RS00435	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THIMO_RS00440	COG0784	Response regulator, receiver
THIMO_RS00440	COG5002	protein histidine kinase activity
THIMO_RS00455	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THIMO_RS00460	COG0004	ammonium transporteR
THIMO_RS00480	COG0606	chelatase, subunit chli
THIMO_RS00485	COG0488	(ABC) transporter
THIMO_RS00490	COG0058	SHG alpha-glucan phosphorylase activity
THIMO_RS00500	COG0750	zinc metalloprotease
THIMO_RS00525	COG4783	chaperone-mediated protein folding
THIMO_RS00555	COG0628	permease
THIMO_RS00565	COG4636	protein conserved in cyanobacteria
THIMO_RS00575	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
THIMO_RS00580	COG0783	Belongs to the Dps family
THIMO_RS00585	COG1058	Belongs to the CinA family
THIMO_RS00585	COG1546	Belongs to the CinA family
THIMO_RS00590	COG0386	Belongs to the glutathione peroxidase family
THIMO_RS00595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
THIMO_RS00605	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
THIMO_RS00610	COG0463	Glycosyl transferase, family 2
THIMO_RS00620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THIMO_RS00630	COG2854	intermembrane phospholipid transfer
THIMO_RS00645	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THIMO_RS00650	COG2084	Dehydrogenase
THIMO_RS00690	COG2221	Nitrite and sulphite reductase 4Fe-4S
THIMO_RS00695	COG2221	Nitrite and sulphite reductase 4Fe-4S
THIMO_RS00700	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
THIMO_RS00705	COG2923	Belongs to the DsrF TusC family
THIMO_RS00715	COG2920	part of a sulfur-relay system
THIMO_RS00750	COG1797	cobyrinic acid a,c-diamide synthase activity
THIMO_RS00765	COG0300	oxidoreductase activity
THIMO_RS00775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THIMO_RS00820	COG1162	GTPase activity
THIMO_RS00830	COG0647	UMP catabolic process
THIMO_RS00850	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THIMO_RS00860	COG1324	tolerance protein
THIMO_RS00865	COG4232	protein-disulfide reductase activity
THIMO_RS00875	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
THIMO_RS00880	COG0511	ligase activity, forming carbon-carbon bonds
THIMO_RS00885	COG0439	Biotin carboxylase
THIMO_RS00890	COG2264	protein methyltransferase activity
THIMO_RS00895	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
THIMO_RS00905	COG0138	bifunctional purine biosynthesis protein purh
THIMO_RS00910	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THIMO_RS00915	COG0151	Belongs to the GarS family
THIMO_RS00920	COG0616	signal peptide processing
THIMO_RS00925	COG0658	competence protein
THIMO_RS00925	COG2333	competence protein COMEC
THIMO_RS00935	COG1136	(ABC) transporter
THIMO_RS00940	COG4591	ABC-type transport system involved in lipoprotein release permease component
THIMO_RS00945	COG2957	Belongs to the agmatine deiminase family
THIMO_RS00955	COG1301	dicarboxylic acid transport
THIMO_RS00965	COG3093	addiction module antidote protein HigA
THIMO_RS01000	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
THIMO_RS01005	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
THIMO_RS01010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THIMO_RS01015	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
THIMO_RS01055	COG0642	Histidine kinase
THIMO_RS01070	COG1151	hydroxylamine reductase activity
THIMO_RS01080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THIMO_RS01085	COG1116	anion transmembrane transporter activity
THIMO_RS01085	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THIMO_RS01100	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
THIMO_RS01100	COG2878	Part of a membrane complex involved in electron transport
THIMO_RS01105	COG4657	Part of a membrane complex involved in electron transport
THIMO_RS01110	COG4660	Part of a membrane complex involved in electron transport
THIMO_RS01115	COG4659	FMN binding
THIMO_RS01120	COG4658	electron transport chain
THIMO_RS01125	COG4656	Part of a membrane complex involved in electron transport
THIMO_RS01130	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
THIMO_RS01140	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
THIMO_RS01145	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
THIMO_RS01150	COG0039	L-malate dehydrogenase activity
THIMO_RS01160	COG0045	succinate-CoA ligase (ADP-forming) activity
THIMO_RS01165	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
THIMO_RS01185	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
THIMO_RS01205	COG0674	pyruvate-flavodoxin oxidoreductase activity
THIMO_RS01205	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THIMO_RS01210	COG1013	pyruvate-flavodoxin oxidoreductase activity
THIMO_RS01220	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
THIMO_RS01300	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THIMO_RS01350	COG1987	bacterial-type flagellum assembly
THIMO_RS01360	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THIMO_RS01365	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THIMO_RS01410	COG1360	Flagellar Motor Protein
THIMO_RS01415	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
THIMO_RS01425	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
THIMO_RS01430	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
THIMO_RS01435	COG0505	Belongs to the CarA family
THIMO_RS01445	COG0577	efflux transmembrane transporter activity
THIMO_RS01450	COG1136	(ABC) transporter
THIMO_RS01450	COG0577	efflux transmembrane transporter activity
THIMO_RS01465	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THIMO_RS01585	COG1943	Transposase
THIMO_RS01590	COG0215	cysteine-tRNA ligase activity
THIMO_RS01595	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
THIMO_RS01615	COG0514	ATP-dependent DNA helicase (RecQ)
THIMO_RS01640	COG2183	response to ionizing radiation
THIMO_RS01655	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
THIMO_RS01660	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THIMO_RS01665	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THIMO_RS01665	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THIMO_RS01675	COG1597	lipid kinase activity
THIMO_RS01680	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
THIMO_RS01705	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
THIMO_RS01710	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
THIMO_RS01715	COG1271	oxidase subunit
THIMO_RS01720	COG1294	oxidase, subunit
THIMO_RS01730	COG4988	ABC transporter
THIMO_RS01735	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
THIMO_RS01780	COG0189	ligase activity
THIMO_RS01800	COG0662	Cupin 2, conserved barrel domain protein
THIMO_RS01805	COG3604	Transcriptional regulator
THIMO_RS01815	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
THIMO_RS01820	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
THIMO_RS01830	COG0028	Belongs to the TPP enzyme family
THIMO_RS01840	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
THIMO_RS01845	COG3034	peptidoglycan biosynthetic process
THIMO_RS01865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
THIMO_RS01900	COG1902	pentaerythritol trinitrate reductase activity
THIMO_RS01940	COG1560	Kdo2-lipid A biosynthetic process
THIMO_RS01950	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THIMO_RS01955	COG2608	mercury ion transmembrane transporter activity
THIMO_RS01960	COG0837	glucose binding
THIMO_RS01970	COG2920	part of a sulfur-relay system
THIMO_RS01980	COG0746	molybdenum cofactor guanylyltransferase activity
THIMO_RS02000	COG1959	2 iron, 2 sulfur cluster binding
THIMO_RS02020	COG0318	PFAM AMP-dependent synthetase and ligase
THIMO_RS02025	COG0544	peptidyl-prolyl cis-trans isomerase activity
THIMO_RS02030	COG0740	serine-type endopeptidase activity
THIMO_RS02035	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
THIMO_RS02040	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THIMO_RS02060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THIMO_RS02070	COG1960	acyl-CoA dehydrogenase activity
THIMO_RS02075	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
THIMO_RS02080	COG2086	electron transfer activity
THIMO_RS02090	COG3228	Belongs to the MtfA family
THIMO_RS02095	COG1999	signal sequence binding
THIMO_RS02120	COG4944	Protein of unknown function (DUF1109)
THIMO_RS02125	COG1595	DNA-templated transcription, initiation
THIMO_RS02135	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
THIMO_RS02150	COG0432	Pfam Uncharacterised protein family UPF0047
THIMO_RS02160	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
THIMO_RS02175	COG3258	Cytochrome c
THIMO_RS02185	COG4636	protein conserved in cyanobacteria
THIMO_RS02190	COG3028	Belongs to the UPF0307 family
THIMO_RS02200	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
THIMO_RS02205	COG1053	succinate dehydrogenase
THIMO_RS02210	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
THIMO_RS02220	COG0789	Transcriptional regulator
THIMO_RS02235	COG3976	FMN-binding domain protein
THIMO_RS02235	COG1053	succinate dehydrogenase
THIMO_RS02240	COG1492	cobalamin metabolic process
THIMO_RS02275	COG0656	L-ascorbic acid biosynthetic process
THIMO_RS02285	COG1492	cobalamin metabolic process
THIMO_RS02335	COG1410	methionine synthase
THIMO_RS02335	COG0646	methionine synthase
THIMO_RS02355	COG4636	protein conserved in cyanobacteria
THIMO_RS02360	COG1797	cobyrinic acid a,c-diamide synthase activity
THIMO_RS02365	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
THIMO_RS02410	COG0745	RESPONSE REGULATOR receiver
THIMO_RS02425	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THIMO_RS02435	COG2200	EAL domain
THIMO_RS02435	COG2203	Gaf domain
THIMO_RS02435	COG2199	diguanylate cyclase activity
THIMO_RS02440	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
THIMO_RS02440	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
THIMO_RS02445	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
THIMO_RS02500	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THIMO_RS02505	COG1530	ribonuclease E activity
THIMO_RS02515	COG0546	phosphoglycolate phosphatase activity
THIMO_RS02520	COG0616	signal peptide processing
THIMO_RS02525	COG1388	LysM domain
THIMO_RS02525	COG0741	lytic transglycosylase activity
THIMO_RS02530	COG0424	maF-like protein
THIMO_RS02560	COG2308	Evidence 4 Homologs of previously reported genes of
THIMO_RS02575	COG2920	part of a sulfur-relay system
THIMO_RS02610	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
THIMO_RS02645	COG0828	Belongs to the bacterial ribosomal protein bS21 family
THIMO_RS02655	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
THIMO_RS02660	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THIMO_RS02665	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
THIMO_RS02670	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
THIMO_RS02705	COG0730	response to heat
THIMO_RS02710	COG0446	pyridine nucleotide-disulphide oxidoreductase
THIMO_RS02715	COG0824	Thioesterase
THIMO_RS02735	COG0823	Involved in the tonB-independent uptake of proteins
THIMO_RS02750	COG0602	queuosine metabolic process
THIMO_RS02770	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
THIMO_RS02775	COG0149	triose-phosphate isomerase activity
THIMO_RS02790	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THIMO_RS02795	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THIMO_RS02800	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THIMO_RS02805	COG0649	NAD binding
THIMO_RS02810	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
THIMO_RS02820	COG1034	ATP synthesis coupled electron transport
THIMO_RS02820	COG1034	ATP synthesis coupled electron transport
THIMO_RS02825	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
THIMO_RS02840	COG0713	ATP synthesis coupled electron transport
THIMO_RS02855	COG1007	ATP synthesis coupled electron transport
THIMO_RS02880	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
THIMO_RS02920	COG0515	serine threonine protein kinase
THIMO_RS02930	COG1570	exodeoxyribonuclease VII activity
THIMO_RS02960	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
THIMO_RS02985	COG3706	GGDEF domain
THIMO_RS02985	COG4251	negative regulation of phosphorylation
THIMO_RS02985	COG5001	Diguanylate cyclase
THIMO_RS02985	COG2203	Gaf domain
THIMO_RS02990	COG0784	Response regulator, receiver
THIMO_RS02990	COG2205	protein histidine kinase activity
THIMO_RS02990	COG5002	protein histidine kinase activity
THIMO_RS02995	COG3706	GGDEF domain
THIMO_RS03025	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
THIMO_RS03045	COG0577	efflux transmembrane transporter activity
THIMO_RS03050	COG1136	(ABC) transporter
THIMO_RS03050	COG0577	efflux transmembrane transporter activity
THIMO_RS03115	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THIMO_RS03120	COG1459	type II secretion system
THIMO_RS03135	COG0741	lytic transglycosylase activity
THIMO_RS03150	COG0672	)-iron permease
THIMO_RS03165	COG0714	Associated with various cellular activities
THIMO_RS03185	COG5002	protein histidine kinase activity
THIMO_RS03185	COG0784	Response regulator, receiver
THIMO_RS03185	COG2205	protein histidine kinase activity
THIMO_RS03190	COG3954	Phosphoribulokinase
THIMO_RS03195	COG4535	Mg2 and Co2 transporter CorC
THIMO_RS03200	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
THIMO_RS03205	COG1702	phosphate starvation-inducible protein PhoH
THIMO_RS03210	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THIMO_RS03225	COG0187	DNA topoisomerase II activity
THIMO_RS03230	COG0433	COG0433 Predicted ATPase
THIMO_RS03240	COG1111	helicase
THIMO_RS03240	COG1205	dead DEAH box helicase
THIMO_RS03255	COG0567	Dehydrogenase, E1 component
THIMO_RS03260	COG0508	dehydrogenase complex catalyzes the overall conversion of
THIMO_RS03275	COG0248	Ppx GppA phosphatase
THIMO_RS03305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
THIMO_RS03340	COG2308	Evidence 4 Homologs of previously reported genes of
THIMO_RS03350	COG3091	SprT-like family
THIMO_RS03355	COG0779	Required for maturation of 30S ribosomal subunits
THIMO_RS03360	COG0195	Participates in both transcription termination and antitermination
THIMO_RS03365	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
THIMO_RS03370	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
THIMO_RS03375	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
THIMO_RS03380	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
THIMO_RS03385	COG1185	polyribonucleotide nucleotidyltransferase activity
THIMO_RS03390	COG3264	Mechanosensitive ion channel
THIMO_RS03390	COG1196	nuclear chromosome segregation
THIMO_RS03400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THIMO_RS03405	COG0267	Belongs to the bacterial ribosomal protein bL33 family
THIMO_RS03410	COG0227	Belongs to the bacterial ribosomal protein bL28 family
THIMO_RS03415	COG0116	Belongs to the methyltransferase superfamily
THIMO_RS03415	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
THIMO_RS03420	COG0288	reversible hydration of carbon dioxide
THIMO_RS03435	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
THIMO_RS03440	COG0024	Methionine aminopeptidase
THIMO_RS03445	COG0052	Belongs to the universal ribosomal protein uS2 family
THIMO_RS03450	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
THIMO_RS03455	COG0528	UMP kinase activity
THIMO_RS03460	COG0233	cytoplasmic translational termination
THIMO_RS03465	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
THIMO_RS03475	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
THIMO_RS03485	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THIMO_RS03495	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THIMO_RS03500	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THIMO_RS03505	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THIMO_RS03520	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
THIMO_RS03530	COG0432	Pfam Uncharacterised protein family UPF0047
THIMO_RS03535	COG3956	TIGRFAM MazG family protein
THIMO_RS03540	COG2003	Belongs to the UPF0758 family
THIMO_RS03545	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THIMO_RS03550	COG0756	dUTP diphosphatase activity
THIMO_RS03560	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THIMO_RS03570	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
THIMO_RS03585	COG1872	DUF167
THIMO_RS03605	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
THIMO_RS03610	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
THIMO_RS03615	COG0515	serine threonine protein kinase
THIMO_RS03615	COG3266	domain, Protein
THIMO_RS03620	COG1561	YicC-like family, N-terminal region
THIMO_RS03625	COG0194	GDP metabolic process
THIMO_RS03630	COG1758	RNA polymerase activity
THIMO_RS03635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THIMO_RS03650	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
THIMO_RS03660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THIMO_RS03665	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
THIMO_RS03690	COG3958	Transketolase
THIMO_RS03730	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
THIMO_RS03760	COG1222	aaa ATPase
THIMO_RS03965	COG1346	cytolysis
THIMO_RS03995	COG0784	Response regulator, receiver
THIMO_RS03995	COG5002	protein histidine kinase activity
THIMO_RS04030	COG0489	protein tyrosine kinase activity
THIMO_RS04045	COG0563	adenylate kinase activity
THIMO_RS04050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THIMO_RS04060	COG1309	transcriptional regulator
THIMO_RS04065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THIMO_RS04070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THIMO_RS04075	COG0500	methyltransferase
THIMO_RS04155	COG1366	Belongs to the anti-sigma-factor antagonist family
THIMO_RS04170	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
THIMO_RS04175	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
THIMO_RS04205	COG0318	PFAM AMP-dependent synthetase and ligase
THIMO_RS04210	COG1850	ribulose-bisphosphate carboxylase activity
THIMO_RS04225	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
THIMO_RS04355	COG1196	nuclear chromosome segregation
THIMO_RS04360	COG3115	cell septum assembly
THIMO_RS04365	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THIMO_RS04385	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
THIMO_RS04390	COG0644	oxidoreductase
THIMO_RS04395	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
THIMO_RS04415	COG0583	DNA-binding transcription factor activity
THIMO_RS04430	COG0310	cobalt ion transport
THIMO_RS04435	COG0310	cobalt ion transport
THIMO_RS04450	COG0825	malonyl-CoA metabolic process
THIMO_RS04455	COG0037	tRNA processing
THIMO_RS04465	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
THIMO_RS04485	COG1177	transmembrane transport
THIMO_RS04490	COG1176	ABC-type spermidine putrescine transport system, permease component I
THIMO_RS04495	COG3842	ATPase activity
THIMO_RS04505	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
THIMO_RS04510	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
THIMO_RS04550	COG4251	negative regulation of phosphorylation
THIMO_RS04555	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
THIMO_RS04560	COG1024	Enoyl-CoA hydratase
THIMO_RS04570	COG0489	protein tyrosine kinase activity
THIMO_RS04575	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THIMO_RS04575	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THIMO_RS04580	COG4657	Part of a membrane complex involved in electron transport
THIMO_RS04585	COG2878	Part of a membrane complex involved in electron transport
THIMO_RS04605	COG4660	Part of a membrane complex involved in electron transport
THIMO_RS04615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THIMO_RS04620	COG2350	Protein conserved in bacteria
THIMO_RS04625	COG2917	probably involved in intracellular septation
THIMO_RS04630	COG0613	PHP domain protein
THIMO_RS04635	COG0009	L-threonylcarbamoyladenylate synthase
THIMO_RS04640	COG1994	Peptidase M50
THIMO_RS04645	COG0180	Tryptophanyl-tRNA synthetase
THIMO_RS04650	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
THIMO_RS04655	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
THIMO_RS04720	COG0367	asparagine synthase
THIMO_RS04760	COG0367	asparagine synthase
THIMO_RS04770	COG0438	transferase activity, transferring glycosyl groups
THIMO_RS04800	COG2801	Transposase and inactivated derivatives
THIMO_RS04805	COG0673	inositol 2-dehydrogenase activity
THIMO_RS04810	COG2226	methyltransferase
THIMO_RS04895	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
THIMO_RS04900	COG0316	Belongs to the HesB IscA family
THIMO_RS04910	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
THIMO_RS04940	COG4464	protein tyrosine phosphatase activity
THIMO_RS04955	COG2951	lytic endotransglycosylase activity
THIMO_RS04960	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THIMO_RS04965	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
THIMO_RS04975	COG0237	dephospho-CoA kinase activity
THIMO_RS05000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THIMO_RS05005	COG1331	Highly conserved protein containing a thioredoxin domain
THIMO_RS05010	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
THIMO_RS05025	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
THIMO_RS05030	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
THIMO_RS05040	COG0343	queuine tRNA-ribosyltransferase activity
THIMO_RS05045	COG1862	Preprotein translocase
THIMO_RS05050	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THIMO_RS05055	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THIMO_RS05080	COG1385	rRNA (uridine-N3-)-methyltransferase activity
THIMO_RS05085	COG2363	Small membrane protein
THIMO_RS05095	COG0165	Argininosuccinate lyase
THIMO_RS05115	COG2027	D-alanyl-D-alanine carboxypeptidase
THIMO_RS05120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THIMO_RS05125	COG1047	Peptidyl-prolyl cis-trans
THIMO_RS05140	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
THIMO_RS05145	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
THIMO_RS05155	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
THIMO_RS05160	COG0495	leucyl-tRNA aminoacylation
THIMO_RS05165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THIMO_RS05170	COG0508	dehydrogenase complex catalyzes the overall conversion of
THIMO_RS05225	COG0436	Aminotransferase
THIMO_RS05240	COG0429	hydrolase of the alpha beta-hydrolase fold
THIMO_RS05245	COG1538	Outer membrane efflux protein
THIMO_RS05250	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
THIMO_RS05280	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
THIMO_RS05305	COG2267	carboxylic ester hydrolase activity
THIMO_RS05320	COG2304	oxidoreductase activity
THIMO_RS05340	COG0714	Associated with various cellular activities
THIMO_RS05350	COG1217	gtp-binding protein TYPA
THIMO_RS05370	COG2146	nitrite reductase [NAD(P)H] activity
THIMO_RS05375	COG0826	peptidase U32
THIMO_RS05380	COG0826	peptidase U32
THIMO_RS05385	COG1242	4 iron, 4 sulfur cluster binding
THIMO_RS05400	COG3100	YcgL domain-containing protein
THIMO_RS05400	COG0561	phosphatase activity
THIMO_RS05405	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
THIMO_RS05430	COG0189	ligase activity
THIMO_RS05440	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
THIMO_RS05445	COG0196	riboflavin kinase activity
THIMO_RS05450	COG0728	peptidoglycan biosynthetic process
THIMO_RS05455	COG0438	transferase activity, transferring glycosyl groups
THIMO_RS05460	COG5002	protein histidine kinase activity
THIMO_RS05460	COG5001	Diguanylate cyclase
THIMO_RS05495	COG0471	metal ion transport
THIMO_RS05495	COG3273	potassium ion transport
THIMO_RS05520	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THIMO_RS05525	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
THIMO_RS05535	COG0598	Magnesium transport protein CorA
THIMO_RS05540	COG0714	Associated with various cellular activities
THIMO_RS05545	COG0445	tRNA wobble uridine modification
THIMO_RS05550	COG0357	Ribosomal RNA small subunit methyltransferase G
THIMO_RS05555	COG1192	Involved in chromosome partitioning
THIMO_RS05560	COG1475	DNA binding
THIMO_RS05570	COG0356	it plays a direct role in the translocation of protons across the membrane
THIMO_RS05580	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
THIMO_RS05585	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THIMO_RS05590	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
THIMO_RS05600	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
THIMO_RS05605	COG0355	proton-transporting ATP synthase activity, rotational mechanism
THIMO_RS05610	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
THIMO_RS05615	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THIMO_RS05625	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THIMO_RS05630	COG0134	indole-3-glycerol-phosphate synthase activity
THIMO_RS05645	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
THIMO_RS05650	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
THIMO_RS05655	COG0247	lactate metabolic process
THIMO_RS05660	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
THIMO_RS05680	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
THIMO_RS05685	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
THIMO_RS05690	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
THIMO_RS05705	COG3079	Belongs to the UPF0149 family
THIMO_RS05710	COG0006	proline dipeptidase activity
THIMO_RS05715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
THIMO_RS05720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
THIMO_RS05725	COG0205	6-phosphofructokinase activity
THIMO_RS05730	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
THIMO_RS05735	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
THIMO_RS05740	COG0315	cyclic pyranopterin monophosphate synthase activity
THIMO_RS05750	COG0218	Necessary for normal cell division and for the maintenance of normal septation
THIMO_RS05760	COG0529	Catalyzes the synthesis of activated sulfate
THIMO_RS05765	COG2171	N-acyltransferase activity
THIMO_RS05770	COG0436	Aminotransferase
THIMO_RS05790	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
THIMO_RS05800	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THIMO_RS05800	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THIMO_RS05815	COG1047	Peptidyl-prolyl cis-trans
THIMO_RS05845	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THIMO_RS05865	COG0037	tRNA processing
THIMO_RS05870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THIMO_RS05895	COG1012	belongs to the aldehyde dehydrogenase family
THIMO_RS05900	COG0114	fumarate hydratase activity
THIMO_RS05910	COG3437	response regulator, receiver
THIMO_RS05925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
THIMO_RS05930	COG0569	domain protein
THIMO_RS05935	COG2204	response regulator
THIMO_RS05940	COG5000	phosphorelay sensor kinase activity
THIMO_RS05955	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THIMO_RS05960	COG0242	peptide deformylase activity
THIMO_RS05970	COG0758	DNA mediated transformation
THIMO_RS05975	COG2922	Belongs to the Smg family
THIMO_RS05985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THIMO_RS05990	COG1321	iron dependent repressor
THIMO_RS05990	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THIMO_RS05995	COG1121	(ABC) transporter
THIMO_RS06000	COG0803	Belongs to the bacterial solute-binding protein 9 family
THIMO_RS06010	COG0009	L-threonylcarbamoyladenylate synthase
THIMO_RS06020	COG1408	metallophosphoesterase
THIMO_RS06025	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
THIMO_RS06035	COG0741	lytic transglycosylase activity
THIMO_RS06040	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
THIMO_RS06045	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
THIMO_RS06050	COG2914	Belongs to the UPF0125 (RnfH) family
THIMO_RS06060	COG4659	FMN binding
THIMO_RS06065	COG4658	electron transport chain
THIMO_RS06070	COG4656	Part of a membrane complex involved in electron transport
THIMO_RS06075	COG2878	Part of a membrane complex involved in electron transport
THIMO_RS06080	COG4657	Part of a membrane complex involved in electron transport
THIMO_RS06095	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
THIMO_RS06100	COG1518	maintenance of DNA repeat elements
THIMO_RS06100	COG1468	defense response to virus
THIMO_RS06140	COG3744	PilT protein domain protein
THIMO_RS06175	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
THIMO_RS06180	COG0402	S-adenosylhomocysteine deaminase activity
THIMO_RS06190	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THIMO_RS06190	COG3620	sequence-specific DNA binding
THIMO_RS06190	COG0617	tRNA 3'-terminal CCA addition
THIMO_RS06195	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
THIMO_RS06225	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
THIMO_RS06230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THIMO_RS06235	COG1605	Chorismate mutase
THIMO_RS06235	COG0077	Prephenate dehydratase
THIMO_RS06240	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THIMO_RS06245	COG0287	Prephenate dehydrogenase
THIMO_RS06265	COG4974	Belongs to the 'phage' integrase family
THIMO_RS06270	COG0471	metal ion transport
THIMO_RS06270	COG0490	domain, Protein
THIMO_RS06285	COG0142	geranyltranstransferase activity
THIMO_RS06290	COG0261	This protein binds to 23S rRNA in the presence of protein L20
THIMO_RS06300	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THIMO_RS06305	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
THIMO_RS06315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THIMO_RS06325	COG0504	CTP synthase activity
THIMO_RS06330	COG2877	3-deoxy-8-phosphooctulonate synthase activity
THIMO_RS06335	COG0148	phosphopyruvate hydratase activity
THIMO_RS06340	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
THIMO_RS06345	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
THIMO_RS06350	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
THIMO_RS06355	COG0585	pseudouridine synthase activity
THIMO_RS06365	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
THIMO_RS06375	COG1238	metal cluster binding
THIMO_RS06405	COG3278	Belongs to the heme-copper respiratory oxidase family
THIMO_RS06420	COG2010	Cytochrome c
THIMO_RS06425	COG0348	domain, Protein
THIMO_RS06435	COG2217	Heavy metal translocating P-type atpase
THIMO_RS06445	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
THIMO_RS06450	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
THIMO_RS06455	COG0438	transferase activity, transferring glycosyl groups
THIMO_RS06465	COG4235	cytochrome complex assembly
THIMO_RS06475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THIMO_RS06485	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
THIMO_RS06495	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
THIMO_RS06500	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
THIMO_RS06505	COG4133	protoheme IX ABC transporter activity
THIMO_RS06510	COG0181	hydroxymethylbilane synthase activity
THIMO_RS06515	COG1587	Uroporphyrinogen-III synthase
THIMO_RS06540	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
THIMO_RS06555	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
THIMO_RS06560	COG3008	intermembrane lipid transfer
THIMO_RS06565	COG2995	paraquat-inducible protein a
THIMO_RS06570	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
THIMO_RS06580	COG2154	pterin-4-alpha-carbinolamine dehydratase
THIMO_RS06630	COG0655	NAD(P)H dehydrogenase (quinone) activity
THIMO_RS06650	COG4251	negative regulation of phosphorylation
THIMO_RS06655	COG1796	DNA polymerase
THIMO_RS06655	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
THIMO_RS06660	COG0588	phosphoglycerate mutase activity
THIMO_RS06690	COG3174	membrane
THIMO_RS06715	COG2204	response regulator
THIMO_RS06735	COG0167	dihydroorotate dehydrogenase activity
THIMO_RS06740	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
THIMO_RS06740	COG0674	pyruvate-flavodoxin oxidoreductase activity
THIMO_RS06740	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THIMO_RS06740	COG1013	pyruvate-flavodoxin oxidoreductase activity
THIMO_RS06745	COG0076	glutamate decarboxylase activity
THIMO_RS06755	COG3864	Putative metallopeptidase domain
THIMO_RS06785	COG4783	chaperone-mediated protein folding
THIMO_RS06800	COG0438	transferase activity, transferring glycosyl groups
THIMO_RS06855	COG0577	efflux transmembrane transporter activity
THIMO_RS06855	COG1136	(ABC) transporter
THIMO_RS06860	COG1136	(ABC) transporter
THIMO_RS06860	COG0577	efflux transmembrane transporter activity
THIMO_RS06865	COG1136	(ABC) transporter
THIMO_RS06885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THIMO_RS06905	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
THIMO_RS06915	COG4206	TonB-dependent receptor
THIMO_RS06945	COG1032	radical SAM domain protein
THIMO_RS06955	COG0583	DNA-binding transcription factor activity
THIMO_RS06960	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
THIMO_RS06965	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
THIMO_RS06995	COG0494	nUDIX hydrolase
THIMO_RS07000	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
THIMO_RS07005	COG0277	FAD linked oxidase domain protein
THIMO_RS07015	COG0792	nuclease activity
THIMO_RS07030	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
THIMO_RS07035	COG1115	amino acid carrier protein
THIMO_RS07040	COG0271	Belongs to the BolA IbaG family
THIMO_RS07075	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
THIMO_RS07085	COG1666	GTP binding
THIMO_RS07095	COG0631	protein serine/threonine phosphatase activity
THIMO_RS07100	COG4636	protein conserved in cyanobacteria
THIMO_RS07115	COG1394	ATPase activity, coupled to movement of substances
THIMO_RS07120	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
THIMO_RS07125	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
THIMO_RS07130	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
THIMO_RS07145	COG1269	ATP hydrolysis coupled proton transport
THIMO_RS07195	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THIMO_RS07220	COG0360	Binds together with S18 to 16S ribosomal RNA
THIMO_RS07225	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
THIMO_RS07235	COG0359	binds to the 23S rRNA
THIMO_RS07245	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
THIMO_RS07255	COG0438	transferase activity, transferring glycosyl groups
THIMO_RS07260	COG0398	Pfam SNARE associated Golgi protein
THIMO_RS07265	COG3237	CsbD-like
THIMO_RS07275	COG0628	permease
THIMO_RS07285	COG2032	superoxide dismutase activity
THIMO_RS07305	COG0724	RNA recognition motif
THIMO_RS07330	COG1126	abc transporter atp-binding protein
THIMO_RS07335	COG1716	ATPase activity
THIMO_RS07335	COG1131	(ABC) transporter
THIMO_RS07335	COG0842	Transport permease protein
THIMO_RS07360	COG0765	amino acid transport
THIMO_RS07365	COG4597	amino acid ABC transporter
THIMO_RS07370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THIMO_RS07380	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
THIMO_RS07395	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
THIMO_RS07435	COG1295	ribonuclease BN
THIMO_RS07445	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THIMO_RS07465	COG4181	ATPase activity
THIMO_RS07480	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
THIMO_RS07480	COG3008	intermembrane lipid transfer
THIMO_RS07495	COG2201	protein-glutamate methylesterase activity
THIMO_RS07505	COG1615	UPF0182 protein
THIMO_RS07530	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
THIMO_RS07540	COG0243	molybdopterin cofactor binding
THIMO_RS07545	COG0437	4 iron, 4 sulfur cluster binding
THIMO_RS07550	COG3302	dmso reductase anchor subunit
THIMO_RS07560	COG3038	cytochrome b561
THIMO_RS07580	COG0446	pyridine nucleotide-disulphide oxidoreductase
THIMO_RS07585	COG0493	'glutamate synthase
THIMO_RS07590	COG2862	Uncharacterized protein family, UPF0114
THIMO_RS07600	COG1201	RNA secondary structure unwinding
THIMO_RS07625	COG1607	acyl-coa hydrolase
THIMO_RS07660	COG1643	Atp-dependent helicase
THIMO_RS07680	COG0012	GTP binding
THIMO_RS07700	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
THIMO_RS07705	COG5002	protein histidine kinase activity
THIMO_RS07705	COG2205	protein histidine kinase activity
THIMO_RS07705	COG0784	Response regulator, receiver
THIMO_RS07715	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THIMO_RS07720	COG1763	Mo-molybdopterin cofactor biosynthetic process
THIMO_RS07730	COG0587	DNA-directed DNA polymerase activity
THIMO_RS07745	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
THIMO_RS07750	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
THIMO_RS07775	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
THIMO_RS07780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THIMO_RS07795	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
THIMO_RS07800	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
THIMO_RS07805	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THIMO_RS07820	COG1254	Belongs to the acylphosphatase family
THIMO_RS07835	COG3243	poly(R)-hydroxyalkanoic acid synthase
THIMO_RS07845	COG0183	Belongs to the thiolase family
THIMO_RS07860	COG1028	Short-chain dehydrogenase reductase Sdr
THIMO_RS07865	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
THIMO_RS07870	COG0723	plastoquinol--plastocyanin reductase activity
THIMO_RS07875	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
THIMO_RS07880	COG2857	Cytochrome c1
THIMO_RS07885	COG0625	glutathione transferase activity
THIMO_RS07890	COG2969	positive regulation of protein catabolic process
THIMO_RS07925	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
THIMO_RS07930	COG0308	aminopeptidase N
THIMO_RS07950	COG3547	Transposase (IS116 IS110 IS902 family)
THIMO_RS07975	COG1131	(ABC) transporter
THIMO_RS07980	COG0842	Transport permease protein
THIMO_RS07985	COG0842	Transport permease protein
THIMO_RS07995	COG0404	The glycine cleavage system catalyzes the degradation of glycine
THIMO_RS08000	COG0509	glycine decarboxylation via glycine cleavage system
THIMO_RS08005	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THIMO_RS08010	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
THIMO_RS08015	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THIMO_RS08020	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
THIMO_RS08025	COG0521	Mo-molybdopterin cofactor biosynthetic process
THIMO_RS08030	COG0303	'Molybdopterin
THIMO_RS08035	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
THIMO_RS08040	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THIMO_RS08045	COG1376	ErfK ybiS ycfS ynhG family protein
THIMO_RS08065	COG2205	protein histidine kinase activity
THIMO_RS08065	COG2198	Histidine kinase
THIMO_RS08065	COG0784	Response regulator, receiver
THIMO_RS08070	COG0860	N-Acetylmuramoyl-L-alanine amidase
THIMO_RS08075	COG0802	atpase or kinase
THIMO_RS08080	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THIMO_RS08080	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
THIMO_RS08085	COG0137	argininosuccinate synthase activity
THIMO_RS08090	COG2954	triphosphatase activity
THIMO_RS08095	COG0747	negative chemotaxis
THIMO_RS08100	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THIMO_RS08105	COG0022	dehydrogenase e1 component
THIMO_RS08110	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
THIMO_RS08130	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
THIMO_RS08140	COG0298	carbon dioxide binding
THIMO_RS08165	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
THIMO_RS08170	COG0284	orotidine-5'-phosphate decarboxylase activity
THIMO_RS08260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THIMO_RS08265	COG1151	hydroxylamine reductase activity
THIMO_RS08270	COG2949	membrane
THIMO_RS08275	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
THIMO_RS08305	COG0018	arginyl-trna synthetase
THIMO_RS08310	COG3153	acetyltransferase
THIMO_RS08310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THIMO_RS08325	COG0071	Belongs to the small heat shock protein (HSP20) family
THIMO_RS08330	COG2133	pyrroloquinoline quinone binding
THIMO_RS08400	COG1840	ABC-type Fe3 transport system, periplasmic component
THIMO_RS08410	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
THIMO_RS08435	COG0582	viral genome integration into host DNA
THIMO_RS08490	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THIMO_RS08510	COG1469	GTP cyclohydrolase I activity
THIMO_RS08515	COG0142	geranyltranstransferase activity
THIMO_RS08520	COG1722	exodeoxyribonuclease VII activity
THIMO_RS08535	COG2212	antiporter activity
THIMO_RS08540	COG1863	multisubunit Na H antiporter MnhE subunit
THIMO_RS08545	COG0651	ATP synthesis coupled electron transport
THIMO_RS08550	COG1006	Multisubunit Na H antiporter MnhC subunit
THIMO_RS08555	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THIMO_RS08555	COG2111	Na H antiporter
THIMO_RS08560	COG1230	cation diffusion facilitator family transporter
THIMO_RS08575	COG1918	ferrous iron import across plasma membrane
THIMO_RS08595	COG0302	gtp cyclohydrolase
THIMO_RS08605	COG0189	ligase activity
THIMO_RS08605	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THIMO_RS08610	COG1363	Peptidase, m42
THIMO_RS08615	COG1162	GTPase activity
THIMO_RS08635	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THIMO_RS08640	COG0123	including yeast histone deacetylase and acetoin utilization protein
THIMO_RS08645	COG0045	succinate-CoA ligase (ADP-forming) activity
THIMO_RS08645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
THIMO_RS08645	COG1042	CoA-binding domain protein
THIMO_RS08660	COG0640	Transcriptional regulator
THIMO_RS08665	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THIMO_RS08670	COG0798	PFAM Bile acid sodium symporter
THIMO_RS08675	COG0701	Predicted permease
THIMO_RS08690	COG0436	Aminotransferase
THIMO_RS08725	COG3086	response to oxidative stress
THIMO_RS08730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THIMO_RS08735	COG0481	GTPase activity
THIMO_RS08740	COG0681	Belongs to the peptidase S26 family
THIMO_RS08750	COG0571	ribonuclease III activity
THIMO_RS08760	COG1381	Involved in DNA repair and RecF pathway recombination
THIMO_RS08765	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
THIMO_RS08795	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
THIMO_RS08825	COG1490	D-aminoacyl-tRNA deacylase activity
THIMO_RS08830	COG0131	Imidazoleglycerol-phosphate dehydratase
THIMO_RS08835	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
THIMO_RS08840	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
THIMO_RS08845	COG0140	phosphoribosyl-ATP diphosphatase activity
THIMO_RS08850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THIMO_RS08855	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THIMO_RS08865	COG0583	DNA-binding transcription factor activity
THIMO_RS08880	COG3876	Protein conserved in bacteria
THIMO_RS08905	COG0693	protein deglycase activity
THIMO_RS08920	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
THIMO_RS08925	COG1979	alcohol dehydrogenase
THIMO_RS08930	COG2207	Transcriptional regulator
THIMO_RS08935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THIMO_RS08940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THIMO_RS08955	COG2226	methyltransferase
THIMO_RS08975	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
THIMO_RS08980	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
THIMO_RS08990	COG0776	regulation of translation
THIMO_RS09000	COG2847	Copper chaperone PCu(A)C
THIMO_RS09010	COG0789	Transcriptional regulator
THIMO_RS09020	COG0640	Transcriptional regulator
THIMO_RS09025	COG1160	GTP binding
THIMO_RS09035	COG2976	Protein conserved in bacteria
THIMO_RS09040	COG0124	histidyl-tRNA synthetase
THIMO_RS09045	COG1426	Protein conserved in bacteria
THIMO_RS09055	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THIMO_RS09060	COG0105	UTP biosynthetic process
THIMO_RS09065	COG3034	peptidoglycan biosynthetic process
THIMO_RS09085	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
THIMO_RS09135	COG3093	addiction module antidote protein HigA
THIMO_RS09150	COG0668	transmembrane transport
THIMO_RS09160	COG0058	SHG alpha-glucan phosphorylase activity
THIMO_RS09165	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
THIMO_RS09175	COG0277	FAD linked oxidase domain protein
THIMO_RS09180	COG0277	FAD linked oxidase domain protein
THIMO_RS09185	COG0247	lactate metabolic process
THIMO_RS09190	COG0513	Belongs to the DEAD box helicase family
THIMO_RS09195	COG0724	RNA recognition motif
THIMO_RS09200	COG0442	prolyl-tRNA aminoacylation
THIMO_RS09205	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THIMO_RS09210	COG4536	flavin adenine dinucleotide binding
THIMO_RS09225	COG2354	Protein conserved in bacteria
THIMO_RS09230	COG0004	ammonium transporteR
THIMO_RS09235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THIMO_RS09240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THIMO_RS09245	COG0280	phosphate acetyltransferase
THIMO_RS09245	COG0857	belongs to the CobB CobQ family
THIMO_RS09250	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
THIMO_RS09260	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THIMO_RS09275	COG0438	transferase activity, transferring glycosyl groups
THIMO_RS09290	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THIMO_RS09305	COG0297	glycogen (starch) synthase activity
THIMO_RS09310	COG1519	Transferase
THIMO_RS09320	COG2046	Belongs to the sulfate adenylyltransferase family
THIMO_RS09335	COG0741	lytic transglycosylase activity
THIMO_RS09340	COG3108	Peptidase M15
THIMO_RS09345	COG0557	exoribonuclease II activity
THIMO_RS09350	COG0354	folic acid binding
THIMO_RS09355	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
THIMO_RS09370	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
THIMO_RS09375	COG0084	hydrolase, TatD family'
THIMO_RS09385	COG3122	Protein conserved in bacteria
THIMO_RS09400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THIMO_RS09410	COG0589	response to stress
THIMO_RS09415	COG0439	Biotin carboxylase
THIMO_RS09420	COG5016	pyruvate
THIMO_RS09420	COG0511	ligase activity, forming carbon-carbon bonds
THIMO_RS09430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THIMO_RS09440	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THIMO_RS09445	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
THIMO_RS09450	COG0739	heme binding
THIMO_RS09450	COG1196	nuclear chromosome segregation
THIMO_RS09450	COG0741	lytic transglycosylase activity
THIMO_RS09455	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
THIMO_RS09545	COG1136	(ABC) transporter
THIMO_RS09565	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
THIMO_RS09570	COG2894	cell division
THIMO_RS09575	COG0850	regulation of cytokinetic process
THIMO_RS09580	COG0537	adenosine 5'-monophosphoramidase activity
THIMO_RS09585	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
THIMO_RS09590	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
THIMO_RS09595	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THIMO_RS09600	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
THIMO_RS09605	COG0488	(ABC) transporter
THIMO_RS09610	COG5001	Diguanylate cyclase
THIMO_RS09610	COG5002	protein histidine kinase activity
THIMO_RS09625	COG3409	Peptidoglycan-binding domain 1 protein
THIMO_RS09625	COG3267	Type II secretory pathway component ExeA
THIMO_RS09630	COG2379	hydroxypyruvate reductase
THIMO_RS09645	COG0628	permease
THIMO_RS09650	COG5001	Diguanylate cyclase
THIMO_RS09650	COG5002	protein histidine kinase activity
THIMO_RS09655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
THIMO_RS09660	COG4279	zinc finger
THIMO_RS09665	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THIMO_RS09690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
THIMO_RS09720	COG5433	transposase activity
THIMO_RS09725	COG5433	transposase activity
THIMO_RS09740	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
THIMO_RS09760	COG1022	Amp-dependent synthetase and ligase
THIMO_RS09770	COG2022	thiamine diphosphate biosynthetic process
THIMO_RS09775	COG0220	tRNA (guanine-N7-)-methyltransferase activity
THIMO_RS09780	COG3842	ATPase activity
THIMO_RS09785	COG0390	transport system, permease component
THIMO_RS09790	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
THIMO_RS09805	COG2193	ferroxidase activity
THIMO_RS09875	COG0745	RESPONSE REGULATOR receiver
THIMO_RS09880	COG2205	protein histidine kinase activity
THIMO_RS09885	COG4452	Inner membrane protein CreD
THIMO_RS09910	COG0601	transmembrane transport
THIMO_RS09915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THIMO_RS09920	COG1472	Belongs to the glycosyl hydrolase 3 family
THIMO_RS09940	COG1477	protein flavinylation
THIMO_RS09950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THIMO_RS09960	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THIMO_RS09965	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
THIMO_RS09975	COG0513	Belongs to the DEAD box helicase family
THIMO_RS09980	COG1011	Hydrolase
THIMO_RS09985	COG0494	nUDIX hydrolase
THIMO_RS10000	COG1902	pentaerythritol trinitrate reductase activity
THIMO_RS10010	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
THIMO_RS10015	COG0542	response to heat
THIMO_RS10020	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
THIMO_RS10025	COG1278	Cold shock
THIMO_RS10030	COG0482	sulfurtransferase activity
THIMO_RS10035	COG2915	High frequency lysogenization protein hflD homolog
THIMO_RS10045	COG1214	PFAM Peptidase M22, glycoprotease
THIMO_RS10050	COG1199	ATP-dependent helicase activity
THIMO_RS10060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
THIMO_RS10065	COG0842	Transport permease protein
THIMO_RS10070	COG1131	(ABC) transporter
THIMO_RS10095	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THIMO_RS10100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
THIMO_RS10100	COG0596	Alpha beta hydrolase
THIMO_RS10100	COG2226	methyltransferase
THIMO_RS10105	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
THIMO_RS10145	COG5522	Integral membrane protein (intg_mem_TP0381)
THIMO_RS10170	COG3045	CreA protein
THIMO_RS10190	COG2925	Exonuclease
THIMO_RS10195	COG0335	large ribosomal subunit rRNA binding
THIMO_RS10200	COG0336	Belongs to the RNA methyltransferase TrmD family
THIMO_RS10205	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
THIMO_RS10210	COG0228	four-way junction DNA binding
THIMO_RS10215	COG2239	Acts as a magnesium transporter
THIMO_RS10220	COG0513	Belongs to the DEAD box helicase family
THIMO_RS10225	COG1671	Belongs to the UPF0178 family
THIMO_RS10260	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
THIMO_RS10275	COG5002	protein histidine kinase activity
THIMO_RS10325	COG4608	Belongs to the ABC transporter superfamily
THIMO_RS10330	COG0444	Belongs to the ABC transporter superfamily
THIMO_RS10375	COG2204	response regulator
THIMO_RS10380	COG1132	(ABC) transporter
THIMO_RS10385	COG1793	dna ligase
THIMO_RS10400	COG1104	cysteine desulfurase activity
THIMO_RS10405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THIMO_RS10410	COG0191	fructose-bisphosphate aldolase activity
THIMO_RS10415	COG0469	pyruvate kinase activity
THIMO_RS10420	COG0126	phosphoglycerate kinase activity
THIMO_RS10425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
THIMO_RS10430	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
THIMO_RS10440	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THIMO_RS10445	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
THIMO_RS10450	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THIMO_RS10455	COG2918	glutathione biosynthetic process
THIMO_RS10465	COG0242	peptide deformylase activity
THIMO_RS10490	COG0347	Belongs to the P(II) protein family
THIMO_RS10510	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THIMO_RS10510	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
THIMO_RS10590	COG3100	YcgL domain-containing protein
THIMO_RS10590	COG0561	phosphatase activity
THIMO_RS10600	COG2151	metal-sulfur cluster biosynthetic enzyme
THIMO_RS10605	COG0719	Fe-S assembly protein
THIMO_RS10610	COG0396	ATPase activity
THIMO_RS10615	COG0719	Fe-S assembly protein
THIMO_RS10625	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
THIMO_RS10635	COG0688	phosphatidylethanolamine metabolic process
THIMO_RS10640	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
THIMO_RS10645	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
THIMO_RS10650	COG1509	lysine 2,3-aminomutase activity
THIMO_RS10700	COG1051	belongs to the nudix hydrolase family
THIMO_RS10705	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
THIMO_RS10710	COG2863	cytochrome
THIMO_RS10715	COG0446	pyridine nucleotide-disulphide oxidoreductase
THIMO_RS10785	COG0542	response to heat
THIMO_RS10810	COG0243	molybdopterin cofactor binding
THIMO_RS10820	COG1394	ATPase activity, coupled to movement of substances
THIMO_RS10825	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
THIMO_RS10830	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
THIMO_RS10890	COG2801	Transposase and inactivated derivatives
THIMO_RS10915	COG0418	dihydroorotase activity
THIMO_RS10925	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THIMO_RS10935	COG1028	Short-chain dehydrogenase reductase Sdr
THIMO_RS10940	COG0723	plastoquinol--plastocyanin reductase activity
THIMO_RS10945	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THIMO_RS10950	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
THIMO_RS10990	COG0516	GMP reductase activity
THIMO_RS10990	COG0517	IMP dehydrogenase activity
THIMO_RS11010	COG2983	Belongs to the UPF0260 family
THIMO_RS11055	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
THIMO_RS11060	COG1074	ATP-dependent DNA helicase activity
THIMO_RS11065	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
THIMO_RS11080	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
THIMO_RS11095	COG4191	Histidine kinase
THIMO_RS11100	COG4566	intracellular signal transduction
THIMO_RS11110	COG1444	tRNA N-acetyltransferase activity
THIMO_RS11120	COG0670	Belongs to the BI1 family
THIMO_RS11130	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
THIMO_RS11135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THIMO_RS11140	COG0557	exoribonuclease II activity
THIMO_RS11150	COG3850	Histidine kinase
THIMO_RS11155	COG2197	response regulator
THIMO_RS11175	COG0647	UMP catabolic process
THIMO_RS11180	COG2308	Evidence 4 Homologs of previously reported genes of
THIMO_RS11180	COG2307	Protein conserved in bacteria
THIMO_RS11185	COG1305	Transglutaminase-like
THIMO_RS11195	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
THIMO_RS11200	COG3118	belongs to the thioredoxin family
THIMO_RS11205	COG3118	belongs to the thioredoxin family
THIMO_RS11215	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THIMO_RS11225	COG1183	phosphatidylcholine synthase activity
THIMO_RS11230	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
THIMO_RS11240	COG3383	formate dehydrogenase (NAD+) activity
THIMO_RS11250	COG3259	Nickel-dependent hydrogenase
THIMO_RS11270	COG2135	peptidase activity
THIMO_RS11295	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
THIMO_RS11305	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
THIMO_RS11315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THIMO_RS11320	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THIMO_RS11325	COG0328	RNA-DNA hybrid ribonuclease activity
THIMO_RS11330	COG2226	methyltransferase
THIMO_RS11335	COG0129	dihydroxy-acid dehydratase activity
THIMO_RS11340	COG0084	hydrolase, TatD family'
THIMO_RS11350	COG0470	DNA polymerase III
THIMO_RS11355	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
THIMO_RS11360	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
THIMO_RS11370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THIMO_RS11375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THIMO_RS11385	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
THIMO_RS11390	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THIMO_RS11395	COG0416	fatty acid biosynthetic process
THIMO_RS11400	COG0333	Belongs to the bacterial ribosomal protein bL32 family
THIMO_RS11405	COG1399	metal-binding, possibly nucleic acid-binding protein
THIMO_RS11410	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
THIMO_RS11415	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
THIMO_RS11425	COG0330	HflC and HflK could
THIMO_RS11430	COG0330	HflC and HflK could
THIMO_RS11435	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
THIMO_RS11440	COG1923	regulation of RNA biosynthetic process
THIMO_RS11445	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
THIMO_RS11450	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
THIMO_RS11465	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THIMO_RS11475	COG3001	Fructosamine kinase
THIMO_RS11490	COG1320	monovalent cation:proton antiporter activity
THIMO_RS11500	COG2111	Na H antiporter
THIMO_RS11505	COG1006	Multisubunit Na H antiporter MnhC subunit
THIMO_RS11510	COG0651	ATP synthesis coupled electron transport
THIMO_RS11515	COG0651	ATP synthesis coupled electron transport
THIMO_RS11525	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THIMO_RS11535	COG0649	NAD binding
THIMO_RS11545	COG1863	multisubunit Na H antiporter MnhE subunit
THIMO_RS11555	COG4717	serine-type aminopeptidase activity
THIMO_RS11560	COG0420	3'-5' exonuclease activity
THIMO_RS11590	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THIMO_RS11600	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
THIMO_RS11605	COG0527	aspartate kinase activity
THIMO_RS11610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
THIMO_RS11615	COG2137	regulation of response to DNA damage stimulus
THIMO_RS11630	COG1546	Belongs to the CinA family
THIMO_RS11640	COG0543	2 iron, 2 sulfur cluster binding
THIMO_RS11640	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
THIMO_RS11650	COG0415	Belongs to the DNA photolyase family
THIMO_RS11655	COG1720	tRNA m6t6A37 methyltransferase activity
THIMO_RS11660	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
THIMO_RS11665	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
THIMO_RS11675	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
THIMO_RS11685	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
THIMO_RS11690	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
THIMO_RS11695	COG1674	ftsk spoiiie
THIMO_RS11700	COG0492	ferredoxin-NADP+ reductase activity
THIMO_RS11710	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
THIMO_RS11715	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
THIMO_RS11720	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
THIMO_RS11770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THIMO_RS11780	COG3547	Transposase (IS116 IS110 IS902 family)
THIMO_RS11795	COG4566	intracellular signal transduction
THIMO_RS11800	COG0668	transmembrane transport
THIMO_RS11835	COG0628	permease
THIMO_RS11880	COG2823	Periplasmic or secreted lipoprotein
THIMO_RS11905	COG3459	Glycosyltransferase 36 associated
THIMO_RS11920	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
THIMO_RS11950	COG0848	biopolymer transport protein
THIMO_RS11955	COG0811	peptide transport
THIMO_RS11960	COG4771	TonB-dependent receptor
THIMO_RS11965	COG0523	cobalamin synthesis protein
THIMO_RS12000	COG0735	belongs to the Fur family
THIMO_RS12005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THIMO_RS12060	COG1136	(ABC) transporter
THIMO_RS12085	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THIMO_RS12095	COG0573	inorganic phosphate transmembrane transporter activity
THIMO_RS12110	COG2239	Acts as a magnesium transporter
THIMO_RS12115	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
THIMO_RS12120	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
THIMO_RS12125	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
THIMO_RS12130	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
THIMO_RS12135	COG0484	heat shock protein binding
THIMO_RS12140	COG0443	Heat shock 70 kDa protein
THIMO_RS12145	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THIMO_RS12150	COG1420	regulation of RNA biosynthetic process
THIMO_RS12155	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
THIMO_RS12160	COG0497	DNA recombination
THIMO_RS12165	COG0735	belongs to the Fur family
THIMO_RS12175	COG2914	Belongs to the UPF0125 (RnfH) family
THIMO_RS12180	COG2867	negative regulation of translational initiation
THIMO_RS12185	COG0733	neurotransmitter:sodium symporter activity
THIMO_RS12190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THIMO_RS12195	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
THIMO_RS12205	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
THIMO_RS12210	COG0189	ligase activity
THIMO_RS12225	COG1678	Uncharacterized ACR, COG1678
THIMO_RS12230	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
THIMO_RS12240	COG0540	Belongs to the ATCase OTCase family
THIMO_RS12245	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
THIMO_RS12275	COG1166	arginine decarboxylase activity
THIMO_RS12280	COG0375	protein maturation
THIMO_RS12335	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
THIMO_RS12340	COG0405	Gamma-glutamyltransferase
THIMO_RS12350	COG0488	(ABC) transporter
THIMO_RS12360	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
THIMO_RS12420	COG5433	transposase activity
THIMO_RS12425	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
THIMO_RS12430	COG0424	maF-like protein
THIMO_RS12450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THIMO_RS12455	COG0312	modulator of DNA gyrase
THIMO_RS12460	COG0312	modulator of DNA gyrase
THIMO_RS12470	COG1592	Rubrerythrin
THIMO_RS12475	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
THIMO_RS12480	COG3909	cytochrome
THIMO_RS12500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THIMO_RS12520	COG0322	excinuclease ABC activity
THIMO_RS12525	COG2197	response regulator
THIMO_RS12535	COG2390	Transcriptional regulator
THIMO_RS12535	COG4584	PFAM Integrase catalytic
THIMO_RS12565	COG0717	Belongs to the dCTP deaminase family
THIMO_RS12570	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
THIMO_RS12595	COG0583	DNA-binding transcription factor activity
THIMO_RS12605	COG2210	Belongs to the sulfur carrier protein TusA family
THIMO_RS12610	COG0425	Belongs to the sulfur carrier protein TusA family
THIMO_RS12615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THIMO_RS12620	COG1648	precorrin-2 dehydrogenase activity
THIMO_RS12620	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
THIMO_RS12625	COG1968	undecaprenyl-diphosphatase activity
THIMO_RS12640	COG1286	toxin biosynthetic process
THIMO_RS12650	COG0285	dihydrofolate synthase activity
THIMO_RS12655	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
THIMO_RS12660	COG0159	tryptophan synthase activity
THIMO_RS12665	COG0133	tryptophan synthase activity
THIMO_RS12675	COG0101	tRNA pseudouridine synthase activity
THIMO_RS12690	COG0473	3-isopropylmalate dehydrogenase activity
THIMO_RS12695	COG0066	3-isopropylmalate dehydratase activity
THIMO_RS12700	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THIMO_RS12705	COG0268	Binds directly to 16S ribosomal RNA
THIMO_RS12730	COG0489	protein tyrosine kinase activity
THIMO_RS12770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THIMO_RS12790	COG1802	Transcriptional regulator
THIMO_RS12860	COG0741	lytic transglycosylase activity
THIMO_RS12950	COG0419	ATPase involved in DNA repair
THIMO_RS12965	COG0419	ATPase involved in DNA repair
THIMO_RS12985	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
THIMO_RS13035	COG1704	LemA family
THIMO_RS13045	COG2255	four-way junction helicase activity
THIMO_RS13065	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
THIMO_RS13080	COG0357	Ribosomal RNA small subunit methyltransferase G
THIMO_RS13095	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THIMO_RS13105	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
THIMO_RS13110	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THIMO_RS13125	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
THIMO_RS13130	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
THIMO_RS13135	COG1127	ABC transporter
THIMO_RS13145	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
THIMO_RS13160	COG1137	ATPase activity
THIMO_RS13180	COG1660	Displays ATPase and GTPase activities
THIMO_RS13190	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
THIMO_RS13195	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THIMO_RS13205	COG1429	ligase activity, forming nitrogen-metal bonds
THIMO_RS13215	COG3154	lipid carrier protein
THIMO_RS13220	COG0321	lipoyl(octanoyl) transferase activity
THIMO_RS13225	COG1686	Belongs to the peptidase S11 family
THIMO_RS13235	COG2951	lytic endotransglycosylase activity
THIMO_RS13240	COG0772	Belongs to the SEDS family
THIMO_RS13245	COG0768	penicillin binding
THIMO_RS13250	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
THIMO_RS13255	COG1792	Involved in formation and maintenance of cell shape
THIMO_RS13260	COG1077	Cell shape determining protein MreB Mrl
THIMO_RS13265	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THIMO_RS13270	COG0154	amidase activity
THIMO_RS13275	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THIMO_RS13280	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THIMO_RS13285	COG1719	4-vinyl reductase, 4VR
THIMO_RS13295	COG0189	ligase activity
THIMO_RS13295	COG0569	domain protein
THIMO_RS13305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
THIMO_RS13310	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THIMO_RS13330	COG0811	peptide transport
THIMO_RS13355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THIMO_RS13365	COG1120	ATPase activity
THIMO_RS13370	COG1850	ribulose-bisphosphate carboxylase activity
THIMO_RS13400	COG0864	Transcriptional regulator
THIMO_RS13430	COG2885	chlorophyll binding
THIMO_RS13435	COG1132	(ABC) transporter
THIMO_RS13445	COG0776	regulation of translation
THIMO_RS13450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THIMO_RS13450	COG0072	phenylalanine-tRNA ligase activity
THIMO_RS13455	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
THIMO_RS13465	COG0291	Belongs to the bacterial ribosomal protein bL35 family
THIMO_RS13475	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THIMO_RS13490	COG0604	alcohol dehydrogenase
THIMO_RS13500	COG0203	ribosomal protein L17
THIMO_RS13505	COG0202	RNA polymerase activity
THIMO_RS13510	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
THIMO_RS13515	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
THIMO_RS13520	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
THIMO_RS13530	COG0201	protein transport
THIMO_RS13535	COG0200	Binds to the 23S rRNA
THIMO_RS13540	COG1841	ribosomal large subunit assembly
THIMO_RS13545	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
THIMO_RS13550	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
THIMO_RS13555	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
THIMO_RS13560	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
THIMO_RS13565	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
THIMO_RS13570	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
THIMO_RS13575	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
THIMO_RS13580	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
THIMO_RS13585	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
THIMO_RS13590	COG0255	Belongs to the universal ribosomal protein uL29 family
THIMO_RS13595	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
THIMO_RS13600	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
THIMO_RS13605	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
THIMO_RS13610	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
THIMO_RS13615	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
THIMO_RS13620	COG0089	rRNA binding
THIMO_RS13625	COG0088	Forms part of the polypeptide exit tunnel
THIMO_RS13630	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
THIMO_RS13635	COG0051	transcription antitermination factor activity, RNA binding
THIMO_RS13640	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THIMO_RS13645	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THIMO_RS13650	COG0049	tRNA binding
THIMO_RS13655	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
THIMO_RS13660	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
THIMO_RS13665	COG0085	RNA polymerase activity
THIMO_RS13670	COG0222	ribosome binding
THIMO_RS13675	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
THIMO_RS13680	COG0081	regulation of translation
THIMO_RS13685	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
THIMO_RS13695	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THIMO_RS13705	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THIMO_RS13745	COG1943	Transposase
THIMO_RS13755	COG4249	Peptidase C14 caspase catalytic subunit p20
THIMO_RS13755	COG2319	Wd-40 repeat
THIMO_RS13765	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THIMO_RS13770	COG0426	domain, Protein
THIMO_RS13770	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
THIMO_RS13780	COG0596	Alpha beta hydrolase
THIMO_RS13810	COG2217	Heavy metal translocating P-type atpase
THIMO_RS13830	COG0259	pyridoxamine-phosphate oxidase activity
THIMO_RS13840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
THIMO_RS13875	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
THIMO_RS13880	COG3132	Protein of unknown function, DUF480
THIMO_RS13885	COG2949	membrane
THIMO_RS13900	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
THIMO_RS13940	COG2304	oxidoreductase activity
THIMO_RS13960	COG0714	Associated with various cellular activities
THIMO_RS13965	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THIMO_RS13970	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
THIMO_RS13985	COG2885	chlorophyll binding
THIMO_RS14000	COG0583	DNA-binding transcription factor activity
THIMO_RS14005	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THIMO_RS14010	COG3002	Belongs to the UPF0753 family
THIMO_RS14015	COG1850	ribulose-bisphosphate carboxylase activity
THIMO_RS14020	COG4451	ribulose bisphosphate carboxylase, small
THIMO_RS14045	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
THIMO_RS14050	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
THIMO_RS14070	COG0583	DNA-binding transcription factor activity
THIMO_RS14075	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
THIMO_RS14090	COG5265	(ABC) transporter
THIMO_RS14100	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
THIMO_RS14105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THIMO_RS14110	COG2716	regulation of RNA biosynthetic process
THIMO_RS14115	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THIMO_RS14120	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
THIMO_RS14125	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
THIMO_RS14130	COG0720	synthase
THIMO_RS14135	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
THIMO_RS14150	COG2814	Major facilitator Superfamily
THIMO_RS14285	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
THIMO_RS14290	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
THIMO_RS14295	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
THIMO_RS14300	COG1063	alcohol dehydrogenase
THIMO_RS14305	COG0500	methyltransferase
THIMO_RS14310	COG0142	geranyltranstransferase activity
THIMO_RS14325	COG1562	ergosterol biosynthetic process
THIMO_RS14330	COG1233	COG1233 Phytoene dehydrogenase and related
THIMO_RS14340	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
THIMO_RS14370	COG2814	Major facilitator Superfamily
THIMO_RS14380	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
THIMO_RS14385	COG1429	ligase activity, forming nitrogen-metal bonds
THIMO_RS14395	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
THIMO_RS14415	COG2267	carboxylic ester hydrolase activity
THIMO_RS14420	COG0156	8-amino-7-oxononanoate synthase activity
THIMO_RS14425	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THIMO_RS14450	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
THIMO_RS14455	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
THIMO_RS14460	COG0686	Belongs to the AlaDH PNT family
THIMO_RS14470	COG0326	Molecular chaperone. Has ATPase activity
THIMO_RS14475	COG0033	Phosphoglucomutase
THIMO_RS14480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THIMO_RS14490	COG1051	belongs to the nudix hydrolase family
THIMO_RS14495	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
THIMO_RS14510	COG1355	regulation of microtubule-based process
THIMO_RS14540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
THIMO_RS14570	COG4372	Transposase
THIMO_RS14610	COG2244	polysaccharide biosynthetic process
THIMO_RS14650	COG2204	response regulator
THIMO_RS14655	COG0741	lytic transglycosylase activity
THIMO_RS14710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
THIMO_RS14715	COG0514	ATP-dependent DNA helicase (RecQ)
THIMO_RS14730	COG2814	Major facilitator Superfamily
THIMO_RS14745	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
THIMO_RS14760	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
THIMO_RS14765	COG1181	Belongs to the D-alanine--D-alanine ligase family
THIMO_RS14770	COG0812	UDP-N-acetylmuramate dehydrogenase activity
THIMO_RS14775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THIMO_RS14780	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THIMO_RS14785	COG0772	Belongs to the SEDS family
THIMO_RS14790	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
THIMO_RS14795	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THIMO_RS14800	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
THIMO_RS14805	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THIMO_RS14815	COG3116	cell division
THIMO_RS14820	COG0275	rRNA processing
THIMO_RS14830	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
THIMO_RS14840	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THIMO_RS14845	COG1131	(ABC) transporter
THIMO_RS14855	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
THIMO_RS14870	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
THIMO_RS14875	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
THIMO_RS14885	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
THIMO_RS14895	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
THIMO_RS14900	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
THIMO_RS14905	COG0193	aminoacyl-tRNA hydrolase activity
THIMO_RS14910	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
THIMO_RS14920	COG5002	protein histidine kinase activity
THIMO_RS14925	COG0745	RESPONSE REGULATOR receiver
THIMO_RS14930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THIMO_RS14935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THIMO_RS14955	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
THIMO_RS14965	COG0210	DNA helicase
THIMO_RS14985	COG1160	GTP binding
THIMO_RS14995	COG1272	protein, Hemolysin III
THIMO_RS15000	COG1131	(ABC) transporter
THIMO_RS15015	COG0588	phosphoglycerate mutase activity
THIMO_RS15020	COG3706	GGDEF domain
THIMO_RS15030	COG1335	isochorismatase
THIMO_RS15070	COG1643	Atp-dependent helicase
THIMO_RS15080	COG4953	penicillin-binding protein 1C
THIMO_RS15110	COG3842	ATPase activity
THIMO_RS15115	COG4149	molybdate abc transporter
THIMO_RS15140	COG0848	biopolymer transport protein
THIMO_RS15145	COG0811	peptide transport
THIMO_RS15160	COG1830	Aldolase
THIMO_RS15170	COG0393	Putative heavy-metal-binding
THIMO_RS15205	COG3409	Peptidoglycan-binding domain 1 protein
THIMO_RS15205	COG3773	Cell wall hydrolase
THIMO_RS15220	COG0651	ATP synthesis coupled electron transport
THIMO_RS15225	COG0650	Formate hydrogenlyase subunit 4
THIMO_RS15235	COG0651	ATP synthesis coupled electron transport
THIMO_RS15240	COG0649	NAD binding
THIMO_RS15245	COG3260	NADH ubiquinone oxidoreductase 20
THIMO_RS15320	COG1487	ribonuclease activity
THIMO_RS15345	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
THIMO_RS15350	COG1028	Short-chain dehydrogenase reductase Sdr
THIMO_RS15355	COG2801	Transposase and inactivated derivatives
THIMO_RS15385	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
THIMO_RS15415	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
THIMO_RS15435	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
THIMO_RS15465	COG0426	domain, Protein
THIMO_RS15470	COG0633	Ferredoxin
THIMO_RS15490	COG5001	Diguanylate cyclase
THIMO_RS15490	COG5002	protein histidine kinase activity
THIMO_RS15490	COG3447	MASE1 domain protein
THIMO_RS15510	COG0281	malic enzyme
THIMO_RS15510	COG0280	phosphate acetyltransferase
THIMO_RS15515	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THIMO_RS15520	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
THIMO_RS15525	COG2967	ApaG domain
THIMO_RS15540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THIMO_RS15545	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
THIMO_RS15570	COG2813	Specifically methylates the guanine in position
THIMO_RS15580	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
THIMO_RS15590	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
THIMO_RS15605	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
THIMO_RS15610	COG2226	methyltransferase
THIMO_RS15625	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THIMO_RS15630	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
THIMO_RS15650	COG2211	Major facilitator Superfamily
THIMO_RS15655	COG0702	epimerase
THIMO_RS15685	COG2205	protein histidine kinase activity
THIMO_RS15695	COG0745	RESPONSE REGULATOR receiver
THIMO_RS15700	COG1234	tRNA 3'-trailer cleavage
THIMO_RS15705	COG0494	nUDIX hydrolase
THIMO_RS15715	COG0316	Belongs to the HesB IscA family
THIMO_RS15720	COG1704	LemA family
THIMO_RS15730	COG5001	Diguanylate cyclase
THIMO_RS15760	COG0596	Alpha beta hydrolase
THIMO_RS15775	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
THIMO_RS15790	COG4948	Mandelate Racemase Muconate Lactonizing
THIMO_RS15805	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
THIMO_RS15810	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
THIMO_RS15815	COG1278	Cold shock
THIMO_RS15820	COG0330	HflC and HflK could
THIMO_RS15830	COG0314	molybdopterin synthase activity
THIMO_RS15840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THIMO_RS15840	COG0574	Belongs to the PEP-utilizing enzyme family
THIMO_RS15845	COG0525	valine-tRNA ligase activity
THIMO_RS15850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THIMO_RS15860	COG2853	Lipoprotein
THIMO_RS15865	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
THIMO_RS15875	COG0367	asparagine synthase
THIMO_RS15890	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
THIMO_RS15900	COG1850	ribulose-bisphosphate carboxylase activity
THIMO_RS15915	COG2181	nitrate reductase activity
THIMO_RS15960	COG2249	NAD(P)H dehydrogenase (quinone) activity
THIMO_RS15975	COG0649	NAD binding
THIMO_RS15985	COG3260	NADH ubiquinone oxidoreductase 20
THIMO_RS15995	COG2111	Na H antiporter
THIMO_RS15995	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THIMO_RS16000	COG1573	uracil-dna glycosylase
THIMO_RS16005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THIMO_RS16030	COG1151	hydroxylamine reductase activity
THIMO_RS16055	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
THIMO_RS16060	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
THIMO_RS16065	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
THIMO_RS16070	COG0811	peptide transport
THIMO_RS16075	COG0848	biopolymer transport protein
THIMO_RS16080	COG1132	(ABC) transporter
THIMO_RS16085	COG1663	tetraacyldisaccharide 4'-kinase activity
THIMO_RS16090	COG2835	tetraacyldisaccharide 4'-kinase activity
THIMO_RS16095	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
THIMO_RS16145	COG2217	Heavy metal translocating P-type atpase
THIMO_RS16155	COG0306	phosphate transporter
THIMO_RS16160	COG0617	tRNA 3'-terminal CCA addition
THIMO_RS16265	COG0501	Belongs to the peptidase M48B family
THIMO_RS16270	COG2010	Cytochrome c
THIMO_RS16275	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
THIMO_RS16285	COG1752	Esterase of the alpha-beta hydrolase superfamily
THIMO_RS16295	COG2205	protein histidine kinase activity
THIMO_RS16300	COG0745	RESPONSE REGULATOR receiver
THIMO_RS16345	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
THIMO_RS16350	COG0297	glycogen (starch) synthase activity
THIMO_RS16355	COG0366	Alpha amylase catalytic
THIMO_RS16365	COG0019	diaminopimelate decarboxylase activity
THIMO_RS16375	COG0708	Exodeoxyribonuclease III
THIMO_RS16380	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THIMO_RS16400	COG5654	RES domain protein
THIMO_RS16435	COG3549	Plasmid maintenance system killer
THIMO_RS16460	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
THIMO_RS16490	COG1328	CTP reductase activity
THIMO_RS16490	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THIMO_RS16555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THIMO_RS16610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THIMO_RS16630	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
THIMO_RS16635	COG4786	Flagellar basal body rod
THIMO_RS16640	COG4787	bacterial-type flagellum-dependent cell motility
THIMO_RS16655	COG1558	bacterial-type flagellum-dependent cell motility
THIMO_RS16670	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
THIMO_RS16695	COG0617	tRNA 3'-terminal CCA addition
THIMO_RS16705	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
THIMO_RS16710	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
THIMO_RS16715	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
THIMO_RS16720	COG0297	glycogen (starch) synthase activity
THIMO_RS16725	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
THIMO_RS16730	COG0166	Belongs to the GPI family
THIMO_RS16735	COG2766	serine protein kinase
THIMO_RS16740	COG2718	Belongs to the UPF0229 family
THIMO_RS16745	COG2719	SpoVR family
THIMO_RS16750	COG2989	Protein conserved in bacteria
THIMO_RS16755	COG0189	ligase activity
THIMO_RS16755	COG4067	protein conserved in archaea
THIMO_RS16830	COG1253	flavin adenine dinucleotide binding
THIMO_RS16840	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
THIMO_RS16860	COG1752	Esterase of the alpha-beta hydrolase superfamily
THIMO_RS16900	COG2205	protein histidine kinase activity
THIMO_RS16925	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
THIMO_RS16930	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
THIMO_RS16945	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
THIMO_RS16945	COG0392	lysyltransferase activity
THIMO_RS16970	COG1132	(ABC) transporter
THIMO_RS17035	COG0367	asparagine synthase
THIMO_RS17075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THIMO_RS17080	COG0516	GMP reductase activity
THIMO_RS17080	COG0517	IMP dehydrogenase activity
THIMO_RS17085	COG0519	Catalyzes the synthesis of GMP from XMP
THIMO_RS17085	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THIMO_RS17100	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
THIMO_RS17105	COG1070	Carbohydrate kinase
THIMO_RS17110	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
THIMO_RS17115	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
THIMO_RS17120	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
THIMO_RS17125	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
THIMO_RS17135	COG0217	transcriptional regulatory protein
THIMO_RS17140	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
THIMO_RS17145	COG0632	four-way junction helicase activity
THIMO_RS17155	COG3577	Aspartyl protease
THIMO_RS17160	COG0028	Belongs to the TPP enzyme family
THIMO_RS17170	COG0071	Belongs to the small heat shock protein (HSP20) family
THIMO_RS17175	COG0071	Belongs to the small heat shock protein (HSP20) family
THIMO_RS17180	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
THIMO_RS17190	COG2177	Part of the ABC transporter FtsEX involved in
THIMO_RS17195	COG2884	Cell division ATP-binding protein ftsE
THIMO_RS17200	COG0552	protein localization to endoplasmic reticulum
THIMO_RS17205	COG0612	Peptidase, M16
THIMO_RS17210	COG0612	Peptidase, M16
THIMO_RS17215	COG0742	ribosomal rna small subunit methyltransferase
THIMO_RS17220	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
THIMO_RS17225	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
THIMO_RS17230	COG0561	phosphatase activity
THIMO_RS17235	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
THIMO_RS17245	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
THIMO_RS17285	COG0560	Phosphoserine phosphatase
THIMO_RS17285	COG3830	Belongs to the UPF0237 family
THIMO_RS17305	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
THIMO_RS17340	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
THIMO_RS17345	COG0546	phosphoglycolate phosphatase activity
THIMO_RS17350	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
THIMO_RS17355	COG0667	Aldo Keto reductase
THIMO_RS17370	COG4175	Glycine betaine
THIMO_RS17390	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
THIMO_RS17410	COG0653	protein targeting
THIMO_RS17415	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
THIMO_RS17420	COG0494	nUDIX hydrolase
THIMO_RS17425	COG0693	protein deglycase activity
THIMO_RS17430	COG0793	Belongs to the peptidase S41A family
THIMO_RS17435	COG4942	peptidase
THIMO_RS17445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THIMO_RS17450	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
THIMO_RS17455	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
THIMO_RS17460	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
THIMO_RS17465	COG0167	dihydroorotate dehydrogenase activity
THIMO_RS17480	COG2204	response regulator
THIMO_RS17485	COG3852	Histidine kinase
THIMO_RS17495	COG0174	glutamine synthetase
THIMO_RS17505	COG0752	glycyl-tRNA synthetase alpha subunit
THIMO_RS17510	COG0751	glycine-tRNA ligase activity
THIMO_RS17515	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
THIMO_RS17570	COG1358	cellular component organization or biogenesis
THIMO_RS17580	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
THIMO_RS17590	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THIMO_RS17595	COG0706	membrane insertase activity
THIMO_RS17605	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
THIMO_RS17830	COG1450	Type ii and iii secretion system protein
THIMO_RS17935	COG0351	phosphomethylpyrimidine kinase
THIMO_RS18045	COG3190	flagellar
THIMO_RS18070	COG0535	radical SAM domain protein
THIMO_RS18115	COG4659	FMN binding
THIMO_RS18175	COG1342	Belongs to the UPF0251 family
THIMO_RS18180	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
THIMO_RS18220	COG3344	reverse transcriptase
THIMO_RS18385	COG0668	transmembrane transport
THIMO_RS18415	COG2319	Wd-40 repeat
THIMO_RS18415	COG4249	Peptidase C14 caspase catalytic subunit p20
THIMO_RS18465	COG3474	cytochrome
THIMO_RS18485	COG1067	ATP-dependent peptidase activity
THIMO_RS18495	COG4966	pilus assembly protein PilW
THIMO_RS18515	COG5002	protein histidine kinase activity
THIMO_RS18515	COG2205	protein histidine kinase activity
THIMO_RS18515	COG0784	Response regulator, receiver
THIMO_RS18530	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
THIMO_RS18555	COG0515	serine threonine protein kinase
THIMO_RS18555	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THIMO_RS18605	COG3156	type II secretion system protein K
THIMO_RS18615	COG0815	Transfers the fatty acyl group on membrane lipoproteins