locus-tag	class	description
COW1_RS00005	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
COW1_RS00015	COG1763	Mo-molybdopterin cofactor biosynthetic process
COW1_RS00020	COG0746	molybdenum cofactor guanylyltransferase activity
COW1_RS00040	COG0318	PFAM AMP-dependent synthetase and ligase
COW1_RS00050	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
COW1_RS00055	COG3118	belongs to the thioredoxin family
COW1_RS00060	COG1074	ATP-dependent DNA helicase activity
COW1_RS00075	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
COW1_RS00080	COG5001	Diguanylate cyclase
COW1_RS00080	COG4251	negative regulation of phosphorylation
COW1_RS00080	COG2203	Gaf domain
COW1_RS00080	COG3706	GGDEF domain
COW1_RS00115	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
COW1_RS00155	COG1484	DNA-dependent DNA replication
COW1_RS00165	COG1309	transcriptional regulator
COW1_RS00175	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
COW1_RS00180	COG1752	Esterase of the alpha-beta hydrolase superfamily
COW1_RS00205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
COW1_RS00210	COG0842	Transport permease protein
COW1_RS00210	COG1129	ABC transporter
COW1_RS00215	COG1129	ABC transporter
COW1_RS00215	COG0842	Transport permease protein
COW1_RS00220	COG0842	Transport permease protein
COW1_RS00235	COG2814	Major facilitator Superfamily
COW1_RS00240	COG1566	PFAM secretion protein HlyD family protein
COW1_RS00250	COG1902	pentaerythritol trinitrate reductase activity
COW1_RS00255	COG0625	glutathione transferase activity
COW1_RS00260	COG1733	regulation of RNA biosynthetic process
COW1_RS00320	COG0270	DNA (cytosine-5-)-methyltransferase activity
COW1_RS00360	COG2856	Zn peptidase
COW1_RS00490	COG0348	domain, Protein
COW1_RS00495	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
COW1_RS00515	COG3039	Transposase
COW1_RS00540	COG2003	Belongs to the UPF0758 family
COW1_RS00585	COG1475	DNA binding
COW1_RS00590	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
COW1_RS00625	COG2894	cell division
COW1_RS00700	COG1546	Belongs to the CinA family
COW1_RS00710	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
COW1_RS00715	COG2137	regulation of response to DNA damage stimulus
COW1_RS00720	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
COW1_RS00725	COG0527	aspartate kinase activity
COW1_RS00730	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
COW1_RS00760	COG2831	hemolysin activation secretion protein
COW1_RS00780	COG0811	peptide transport
COW1_RS00785	COG0848	biopolymer transport protein
COW1_RS00970	COG1061	Type III restriction enzyme res subunit
COW1_RS01005	COG1475	DNA binding
COW1_RS01175	COG3727	T/G mismatch-specific endonuclease activity
COW1_RS01200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
COW1_RS01210	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
COW1_RS01235	COG3177	Filamentation induced by cAMP protein fic
COW1_RS01255	COG1024	Enoyl-CoA hydratase
COW1_RS01260	COG2205	protein histidine kinase activity
COW1_RS01260	COG2198	Histidine kinase
COW1_RS01260	COG0784	Response regulator, receiver
COW1_RS01270	COG2081	HI0933 family
COW1_RS01290	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
COW1_RS01295	COG3002	Belongs to the UPF0753 family
COW1_RS01320	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
COW1_RS01335	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
COW1_RS01360	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
COW1_RS01365	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
COW1_RS01370	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
COW1_RS01380	COG0537	adenosine 5'-monophosphoramidase activity
COW1_RS01385	COG1162	GTPase activity
COW1_RS01390	COG2154	pterin-4-alpha-carbinolamine dehydratase
COW1_RS01400	COG0501	Belongs to the peptidase M48B family
COW1_RS01405	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
COW1_RS01415	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
COW1_RS01425	COG0033	Phosphoglucomutase
COW1_RS01435	COG1959	2 iron, 2 sulfur cluster binding
COW1_RS01445	COG1454	alcohol dehydrogenase
COW1_RS01460	COG5001	Diguanylate cyclase
COW1_RS01460	COG3300	MHYT domain
COW1_RS01470	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
COW1_RS01480	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
COW1_RS01515	COG0058	SHG alpha-glucan phosphorylase activity
COW1_RS01520	COG0537	adenosine 5'-monophosphoramidase activity
COW1_RS01535	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
COW1_RS01555	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
COW1_RS01555	COG3608	succinylglutamate desuccinylase aspartoacylase
COW1_RS01560	COG0746	molybdenum cofactor guanylyltransferase activity
COW1_RS01570	COG1388	LysM domain
COW1_RS01570	COG0741	lytic transglycosylase activity
COW1_RS01580	COG0328	RNA-DNA hybrid ribonuclease activity
COW1_RS01590	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
COW1_RS01605	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
COW1_RS01615	COG2205	protein histidine kinase activity
COW1_RS01620	COG2204	response regulator
COW1_RS01645	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
COW1_RS01665	COG0489	protein tyrosine kinase activity
COW1_RS01675	COG3409	Peptidoglycan-binding domain 1 protein
COW1_RS01675	COG3267	Type II secretory pathway component ExeA
COW1_RS01705	COG0438	transferase activity, transferring glycosyl groups
COW1_RS01710	COG0367	asparagine synthase
COW1_RS01715	COG0438	transferase activity, transferring glycosyl groups
COW1_RS01720	COG0438	transferase activity, transferring glycosyl groups
COW1_RS01755	COG0438	transferase activity, transferring glycosyl groups
COW1_RS01765	COG2166	iron-sulfur cluster assembly
COW1_RS01770	COG0316	Belongs to the HesB IscA family
COW1_RS01775	COG2151	metal-sulfur cluster biosynthetic enzyme
COW1_RS01780	COG0719	Fe-S assembly protein
COW1_RS01785	COG0396	ATPase activity
COW1_RS01790	COG0719	Fe-S assembly protein
COW1_RS01800	COG3119	arylsulfatase activity
COW1_RS01805	COG0457	Tetratricopeptide repeat
COW1_RS01820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
COW1_RS01835	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
COW1_RS01860	COG0409	Hydrogenase expression formation protein
COW1_RS01870	COG0375	protein maturation
COW1_RS01875	COG0298	carbon dioxide binding
COW1_RS01905	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
COW1_RS01920	COG0543	2 iron, 2 sulfur cluster binding
COW1_RS01935	COG1752	Esterase of the alpha-beta hydrolase superfamily
COW1_RS01950	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
COW1_RS01960	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
COW1_RS01970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
COW1_RS02010	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
COW1_RS02030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
COW1_RS02040	COG0191	fructose-bisphosphate aldolase activity
COW1_RS02045	COG1796	DNA polymerase
COW1_RS02045	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
COW1_RS02060	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
COW1_RS02065	COG1067	ATP-dependent peptidase activity
COW1_RS02100	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
COW1_RS02105	COG2944	sequence-specific DNA binding
COW1_RS02125	COG0589	response to stress
COW1_RS02140	COG3100	YcgL domain-containing protein
COW1_RS02140	COG0561	phosphatase activity
COW1_RS02145	COG0084	hydrolase, TatD family'
COW1_RS02165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
COW1_RS02175	COG2350	Protein conserved in bacteria
COW1_RS02180	COG2917	probably involved in intracellular septation
COW1_RS02185	COG0613	PHP domain protein
COW1_RS02190	COG0009	L-threonylcarbamoyladenylate synthase
COW1_RS02195	COG1994	Peptidase M50
COW1_RS02200	COG0180	Tryptophanyl-tRNA synthetase
COW1_RS02210	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
COW1_RS02215	COG1187	pseudouridine synthase activity
COW1_RS02225	COG3706	GGDEF domain
COW1_RS02235	COG1028	Short-chain dehydrogenase reductase Sdr
COW1_RS02240	COG1233	COG1233 Phytoene dehydrogenase and related
COW1_RS02245	COG1562	ergosterol biosynthetic process
COW1_RS02255	COG1322	Protein conserved in bacteria
COW1_RS02270	COG0402	S-adenosylhomocysteine deaminase activity
COW1_RS02275	COG0668	transmembrane transport
COW1_RS02280	COG3047	cAMP biosynthetic process
COW1_RS02280	COG2885	chlorophyll binding
COW1_RS02290	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
COW1_RS02300	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
COW1_RS02305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
COW1_RS02310	COG1605	Chorismate mutase
COW1_RS02310	COG0077	Prephenate dehydratase
COW1_RS02315	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
COW1_RS02320	COG0287	Prephenate dehydrogenase
COW1_RS02325	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
COW1_RS02330	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
COW1_RS02340	COG0776	regulation of translation
COW1_RS02350	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
COW1_RS02355	COG0284	orotidine-5'-phosphate decarboxylase activity
COW1_RS02360	COG1555	photosystem II stabilization
COW1_RS02365	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
COW1_RS02365	COG0662	Cupin 2, conserved barrel domain protein
COW1_RS02400	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
COW1_RS02405	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
COW1_RS02410	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
COW1_RS02415	COG2226	methyltransferase
COW1_RS02435	COG0463	Glycosyl transferase, family 2
COW1_RS02455	COG0436	Aminotransferase
COW1_RS02470	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
COW1_RS02475	COG1858	cytochrome C peroxidase
COW1_RS02485	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
COW1_RS02490	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
COW1_RS02495	COG0291	Belongs to the bacterial ribosomal protein bL35 family
COW1_RS02500	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
COW1_RS02505	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
COW1_RS02515	COG0776	regulation of translation
COW1_RS02525	COG2801	Transposase and inactivated derivatives
COW1_RS02540	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
COW1_RS02550	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
COW1_RS02570	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
COW1_RS02575	COG1053	succinate dehydrogenase
COW1_RS02580	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
COW1_RS02590	COG2954	triphosphatase activity
COW1_RS02605	COG0601	transmembrane transport
COW1_RS02610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
COW1_RS02615	COG1472	Belongs to the glycosyl hydrolase 3 family
COW1_RS02620	COG0668	transmembrane transport
COW1_RS02625	COG1752	Esterase of the alpha-beta hydrolase superfamily
COW1_RS02630	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
COW1_RS02635	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
COW1_RS02640	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
COW1_RS02645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
COW1_RS02645	COG3153	acetyltransferase
COW1_RS02670	COG2801	Transposase and inactivated derivatives
COW1_RS02690	COG3344	reverse transcriptase
COW1_RS02700	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
COW1_RS02705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
COW1_RS02715	COG4106	trans-aconitate 2-methyltransferase activity
COW1_RS02720	COG2983	Belongs to the UPF0260 family
COW1_RS02755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
COW1_RS02760	COG1393	Belongs to the ArsC family
COW1_RS02770	COG0640	Transcriptional regulator
COW1_RS02775	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
COW1_RS02780	COG0798	PFAM Bile acid sodium symporter
COW1_RS02795	COG2133	pyrroloquinoline quinone binding
COW1_RS02800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
COW1_RS02820	COG1320	monovalent cation:proton antiporter activity
COW1_RS02825	COG2212	antiporter activity
COW1_RS02835	COG0651	ATP synthesis coupled electron transport
COW1_RS02840	COG1006	Multisubunit Na H antiporter MnhC subunit
COW1_RS02845	COG2111	Na H antiporter
COW1_RS02845	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
COW1_RS02850	COG2171	N-acyltransferase activity
COW1_RS02880	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
COW1_RS02885	COG0024	Methionine aminopeptidase
COW1_RS02890	COG0052	Belongs to the universal ribosomal protein uS2 family
COW1_RS02895	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
COW1_RS02900	COG0528	UMP kinase activity
COW1_RS02905	COG0233	cytoplasmic translational termination
COW1_RS02910	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
COW1_RS02915	COG0575	Belongs to the CDS family
COW1_RS02920	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
COW1_RS02940	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
COW1_RS02945	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
COW1_RS02950	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
COW1_RS02955	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
COW1_RS02970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
COW1_RS02975	COG0577	efflux transmembrane transporter activity
COW1_RS02975	COG1136	(ABC) transporter
COW1_RS02980	COG0577	efflux transmembrane transporter activity
COW1_RS02980	COG1136	(ABC) transporter
COW1_RS02990	COG0825	malonyl-CoA metabolic process
COW1_RS03000	COG0504	CTP synthase activity
COW1_RS03005	COG2877	3-deoxy-8-phosphooctulonate synthase activity
COW1_RS03010	COG0148	phosphopyruvate hydratase activity
COW1_RS03015	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
COW1_RS03020	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
COW1_RS03025	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
COW1_RS03030	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
COW1_RS03040	COG1943	Transposase
COW1_RS03075	COG0585	pseudouridine synthase activity
COW1_RS03080	COG1193	negative regulation of DNA recombination
COW1_RS03085	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
COW1_RS03090	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
COW1_RS03095	COG1238	metal cluster binding
COW1_RS03115	COG0436	Aminotransferase
COW1_RS03125	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
COW1_RS03135	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
COW1_RS03145	COG3108	Peptidase M15
COW1_RS03155	COG3263	regulation of cellular component size
COW1_RS03180	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
COW1_RS03185	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
COW1_RS03205	COG1269	ATP hydrolysis coupled proton transport
COW1_RS03225	COG0589	response to stress
COW1_RS03240	COG2239	Acts as a magnesium transporter
COW1_RS03280	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
COW1_RS03320	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
COW1_RS03330	COG2915	High frequency lysogenization protein hflD homolog
COW1_RS03355	COG1278	Cold shock
COW1_RS03360	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
COW1_RS03365	COG0542	response to heat
COW1_RS03370	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
COW1_RS03375	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
COW1_RS03380	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
COW1_RS03390	COG0492	ferredoxin-NADP+ reductase activity
COW1_RS03395	COG0686	Belongs to the AlaDH PNT family
COW1_RS03400	COG1674	ftsk spoiiie
COW1_RS03405	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
COW1_RS03415	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
COW1_RS03420	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
COW1_RS03430	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
COW1_RS03440	COG3706	GGDEF domain
COW1_RS03460	COG0308	aminopeptidase N
COW1_RS03470	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
COW1_RS03470	COG1648	precorrin-2 dehydrogenase activity
COW1_RS03485	COG1252	NADH dehydrogenase
COW1_RS03500	COG2197	response regulator
COW1_RS03505	COG3850	Histidine kinase
COW1_RS03515	COG1797	cobyrinic acid a,c-diamide synthase activity
COW1_RS03550	COG2920	part of a sulfur-relay system
COW1_RS03560	COG2923	Belongs to the DsrF TusC family
COW1_RS03565	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
COW1_RS03570	COG2221	Nitrite and sulphite reductase 4Fe-4S
COW1_RS03575	COG2221	Nitrite and sulphite reductase 4Fe-4S
COW1_RS03605	COG3128	pkhd-type hydroxylase
COW1_RS03620	COG3706	GGDEF domain
COW1_RS03625	COG0730	response to heat
COW1_RS03630	COG0456	acetyltransferase
COW1_RS03655	COG1404	Belongs to the peptidase S8 family
COW1_RS03685	COG0670	Belongs to the BI1 family
COW1_RS03705	COG0740	serine-type endopeptidase activity
COW1_RS03755	COG2204	response regulator
COW1_RS03795	COG1573	uracil-dna glycosylase
COW1_RS03800	COG0322	excinuclease ABC activity
COW1_RS03805	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
COW1_RS03830	COG3588	fructose-bisphosphate aldolase
COW1_RS03850	COG2020	methyltransferase activity
COW1_RS03870	COG0668	transmembrane transport
COW1_RS03880	COG0508	dehydrogenase complex catalyzes the overall conversion of
COW1_RS03890	COG3174	membrane
COW1_RS03900	COG2046	Belongs to the sulfate adenylyltransferase family
COW1_RS03920	COG0189	ligase activity
COW1_RS03925	COG0189	ligase activity
COW1_RS03925	COG4067	protein conserved in archaea
COW1_RS03935	COG3038	cytochrome b561
COW1_RS03975	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
COW1_RS03990	COG0642	Histidine kinase
COW1_RS04020	COG1250	3-hydroxyacyl-CoA dehydrogenase
COW1_RS04020	COG1024	Enoyl-CoA hydratase
COW1_RS04025	COG1022	Amp-dependent synthetase and ligase
COW1_RS04040	COG0084	hydrolase, TatD family'
COW1_RS04055	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
COW1_RS04060	COG1187	pseudouridine synthase activity
COW1_RS04065	COG3245	cytochrome
COW1_RS04075	COG0372	Belongs to the citrate synthase family
COW1_RS04085	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
COW1_RS04090	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
COW1_RS04095	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
COW1_RS04100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
COW1_RS04105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
COW1_RS04110	COG1028	Short-chain dehydrogenase reductase Sdr
COW1_RS04115	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
COW1_RS04120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
COW1_RS04125	COG0416	fatty acid biosynthetic process
COW1_RS04130	COG0333	Belongs to the bacterial ribosomal protein bL32 family
COW1_RS04140	COG0439	Biotin carboxylase
COW1_RS04150	COG0511	ligase activity, forming carbon-carbon bonds
COW1_RS04150	COG5016	pyruvate
COW1_RS04155	COG0424	maF-like protein
COW1_RS04170	COG0546	phosphoglycolate phosphatase activity
COW1_RS04175	COG0564	pseudouridine synthase activity
COW1_RS04180	COG1530	ribonuclease E activity
COW1_RS04185	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
COW1_RS04200	COG4251	negative regulation of phosphorylation
COW1_RS04200	COG5001	Diguanylate cyclase
COW1_RS04200	COG2203	Gaf domain
COW1_RS04200	COG3706	GGDEF domain
COW1_RS04230	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
COW1_RS04235	COG2835	tetraacyldisaccharide 4'-kinase activity
COW1_RS04240	COG1663	tetraacyldisaccharide 4'-kinase activity
COW1_RS04245	COG1132	(ABC) transporter
COW1_RS04250	COG0848	biopolymer transport protein
COW1_RS04255	COG0811	peptide transport
COW1_RS04260	COG2333	competence protein COMEC
COW1_RS04260	COG0658	competence protein
COW1_RS04270	COG1136	(ABC) transporter
COW1_RS04275	COG4591	ABC-type transport system involved in lipoprotein release permease component
COW1_RS04290	COG2957	Belongs to the agmatine deiminase family
COW1_RS04295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
COW1_RS04300	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
COW1_RS04300	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
COW1_RS04305	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
COW1_RS04320	COG0446	pyridine nucleotide-disulphide oxidoreductase
COW1_RS04340	COG2210	Belongs to the sulfur carrier protein TusA family
COW1_RS04365	COG1199	ATP-dependent helicase activity
COW1_RS04380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
COW1_RS04395	COG0500	methyltransferase
COW1_RS04400	COG0277	FAD linked oxidase domain protein
COW1_RS04405	COG0277	FAD linked oxidase domain protein
COW1_RS04410	COG0247	lactate metabolic process
COW1_RS04420	COG0247	lactate metabolic process
COW1_RS04460	COG0579	oxidoreductase
COW1_RS04475	COG1376	ErfK ybiS ycfS ynhG family protein
COW1_RS04490	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
COW1_RS04495	COG3115	cell septum assembly
COW1_RS04505	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
COW1_RS04510	COG1070	Carbohydrate kinase
COW1_RS04520	COG0436	Aminotransferase
COW1_RS04535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
COW1_RS04545	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
COW1_RS04565	COG1185	polyribonucleotide nucleotidyltransferase activity
COW1_RS04570	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
COW1_RS04575	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
COW1_RS04580	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
COW1_RS04585	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
COW1_RS04590	COG0195	Participates in both transcription termination and antitermination
COW1_RS04590	COG2251	uridine kinase activity
COW1_RS04595	COG0779	Required for maturation of 30S ribosomal subunits
COW1_RS04605	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
COW1_RS04620	COG3273	potassium ion transport
COW1_RS04620	COG0471	metal ion transport
COW1_RS04635	COG4221	oxidoreductase activity
COW1_RS04640	COG0789	Transcriptional regulator
COW1_RS04655	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
COW1_RS04675	COG2911	Protein conserved in bacteria
COW1_RS04680	COG0729	surface antigen
COW1_RS04685	COG0563	adenylate kinase activity
COW1_RS04700	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
COW1_RS04705	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
COW1_RS04730	COG1007	ATP synthesis coupled electron transport
COW1_RS04745	COG0713	ATP synthesis coupled electron transport
COW1_RS04755	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
COW1_RS04760	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
COW1_RS04765	COG1034	ATP synthesis coupled electron transport
COW1_RS04780	COG0649	NAD binding
COW1_RS04790	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
COW1_RS04795	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
COW1_RS04800	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
COW1_RS04815	COG0149	triose-phosphate isomerase activity
COW1_RS04820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
COW1_RS04825	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
COW1_RS04830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
COW1_RS04835	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
COW1_RS04850	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
COW1_RS04855	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
COW1_RS04860	COG0505	Belongs to the CarA family
COW1_RS04865	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
COW1_RS04870	COG0484	heat shock protein binding
COW1_RS04875	COG0443	Heat shock 70 kDa protein
COW1_RS04880	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
COW1_RS04885	COG1420	regulation of RNA biosynthetic process
COW1_RS04890	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
COW1_RS04895	COG0497	DNA recombination
COW1_RS04900	COG0735	belongs to the Fur family
COW1_RS04910	COG2914	Belongs to the UPF0125 (RnfH) family
COW1_RS04920	COG0733	neurotransmitter:sodium symporter activity
COW1_RS04925	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
COW1_RS04940	COG1047	Peptidyl-prolyl cis-trans
COW1_RS04965	COG2925	Exonuclease
COW1_RS04980	COG2925	Exonuclease
COW1_RS04985	COG3706	GGDEF domain
COW1_RS05025	COG0450	alkyl hydroperoxide reductase
COW1_RS05045	COG0306	phosphate transporter
COW1_RS05060	COG2226	methyltransferase
COW1_RS05080	COG0398	Pfam SNARE associated Golgi protein
COW1_RS05090	COG0640	Transcriptional regulator
COW1_RS05125	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
COW1_RS05145	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
COW1_RS05170	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
COW1_RS05180	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
COW1_RS05195	COG1216	Glycosyl transferase, family 2
COW1_RS05225	COG0514	ATP-dependent DNA helicase (RecQ)
COW1_RS05230	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
COW1_RS05235	COG1262	PFAM Formylglycine-generating sulfatase enzyme
COW1_RS05255	COG1278	Cold shock
COW1_RS05280	COG0429	hydrolase of the alpha beta-hydrolase fold
COW1_RS05290	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
COW1_RS05295	COG1404	Belongs to the peptidase S8 family
COW1_RS05300	COG4172	Belongs to the ABC transporter superfamily
COW1_RS05305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
COW1_RS05310	COG0601	transmembrane transport
COW1_RS05325	COG1301	dicarboxylic acid transport
COW1_RS05330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
COW1_RS05350	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
COW1_RS05355	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
COW1_RS05360	COG0740	serine-type endopeptidase activity
COW1_RS05365	COG0544	peptidyl-prolyl cis-trans isomerase activity
COW1_RS05395	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
COW1_RS05400	COG5002	protein histidine kinase activity
COW1_RS05400	COG5001	Diguanylate cyclase
COW1_RS05410	COG0215	cysteine-tRNA ligase activity
COW1_RS05415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
COW1_RS05420	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
COW1_RS05425	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
COW1_RS05440	COG2833	Protein of unknown function (DUF455)
COW1_RS05445	COG2379	hydroxypyruvate reductase
COW1_RS05475	COG0285	dihydrofolate synthase activity
COW1_RS05480	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
COW1_RS05485	COG0159	tryptophan synthase activity
COW1_RS05490	COG0133	tryptophan synthase activity
COW1_RS05495	COG0135	phosphoribosylanthranilate isomerase activity
COW1_RS05500	COG0101	tRNA pseudouridine synthase activity
COW1_RS05530	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
COW1_RS05535	COG0473	3-isopropylmalate dehydrogenase activity
COW1_RS05545	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
COW1_RS05560	COG5001	Diguanylate cyclase
COW1_RS05560	COG5002	protein histidine kinase activity
COW1_RS05565	COG1830	Aldolase
COW1_RS05580	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
COW1_RS05610	COG0688	phosphatidylethanolamine metabolic process
COW1_RS05635	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
COW1_RS05640	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
COW1_RS05645	COG1862	Preprotein translocase
COW1_RS05650	COG0343	queuine tRNA-ribosyltransferase activity
COW1_RS05655	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
COW1_RS05670	COG1640	4-alpha-glucanotransferase
COW1_RS05680	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
COW1_RS05685	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
COW1_RS05705	COG1355	regulation of microtubule-based process
COW1_RS05710	COG3885	ferrous iron binding
COW1_RS05710	COG2078	PFAM AMMECR1 domain protein
COW1_RS05740	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
COW1_RS05760	COG0835	chemotaxis
COW1_RS05770	COG1192	Involved in chromosome partitioning
COW1_RS05775	COG2201	protein-glutamate methylesterase activity
COW1_RS05780	COG0643	Histidine kinase
COW1_RS05780	COG2198	Histidine kinase
COW1_RS05780	COG0784	Response regulator, receiver
COW1_RS05785	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
COW1_RS05810	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
COW1_RS05825	COG1987	bacterial-type flagellum assembly
COW1_RS05855	COG3122	Protein conserved in bacteria
COW1_RS05865	COG0513	Belongs to the DEAD box helicase family
COW1_RS05870	COG3344	reverse transcriptase
COW1_RS05875	COG2801	Transposase and inactivated derivatives
COW1_RS05915	COG5001	Diguanylate cyclase
COW1_RS05915	COG3300	MHYT domain
COW1_RS05935	COG1317	bacterial-type flagellum organization
COW1_RS05950	COG1677	Flagellar hook-basal body complex protein FliE
COW1_RS05985	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
COW1_RS05995	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
COW1_RS06000	COG5001	Diguanylate cyclase
COW1_RS06000	COG5002	protein histidine kinase activity
COW1_RS06015	COG3951	Flagellar rod assembly protein muramidase FlgJ
COW1_RS06015	COG1705	Flagellar rod assembly protein muramidase FlgJ
COW1_RS06020	COG1706	bacterial-type flagellum-dependent cell motility
COW1_RS06025	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
COW1_RS06045	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
COW1_RS06060	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
COW1_RS06065	COG0835	chemotaxis
COW1_RS06065	COG0784	Response regulator, receiver
COW1_RS06070	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
COW1_RS06115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
COW1_RS06135	COG1127	ABC transporter
COW1_RS06140	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
COW1_RS06145	COG1366	Belongs to the anti-sigma-factor antagonist family
COW1_RS06165	COG1408	metallophosphoesterase
COW1_RS06185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
COW1_RS06185	COG2198	Histidine kinase
COW1_RS06185	COG0784	Response regulator, receiver
COW1_RS06185	COG2205	protein histidine kinase activity
COW1_RS06210	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
COW1_RS06220	COG0415	Belongs to the DNA photolyase family
COW1_RS06235	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
COW1_RS06255	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
COW1_RS06265	COG1131	(ABC) transporter
COW1_RS06285	COG2308	Evidence 4 Homologs of previously reported genes of
COW1_RS06515	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
COW1_RS06525	COG1205	dead DEAH box helicase
COW1_RS06525	COG1111	helicase
COW1_RS06555	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
COW1_RS06635	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
COW1_RS06640	COG2221	Nitrite and sulphite reductase 4Fe-4S
COW1_RS06645	COG2221	Nitrite and sulphite reductase 4Fe-4S
COW1_RS06650	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
COW1_RS06650	COG0617	tRNA 3'-terminal CCA addition
COW1_RS06650	COG0517	IMP dehydrogenase activity
COW1_RS06660	COG2863	cytochrome
COW1_RS06665	COG3258	Cytochrome c
COW1_RS06670	COG2226	methyltransferase
COW1_RS06705	COG0811	peptide transport
COW1_RS06745	COG1597	lipid kinase activity
COW1_RS06780	COG0456	acetyltransferase
COW1_RS06785	COG1560	Kdo2-lipid A biosynthetic process
COW1_RS06805	COG1132	(ABC) transporter
COW1_RS06825	COG0156	8-amino-7-oxononanoate synthase activity
COW1_RS06830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
COW1_RS06855	COG0583	DNA-binding transcription factor activity
COW1_RS06860	COG2920	part of a sulfur-relay system
COW1_RS06865	COG0516	GMP reductase activity
COW1_RS06865	COG0517	IMP dehydrogenase activity
COW1_RS06875	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
COW1_RS06895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
COW1_RS06905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
COW1_RS06925	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
COW1_RS06985	COG2814	Major facilitator Superfamily
COW1_RS06990	COG0842	Transport permease protein
COW1_RS06995	COG0842	Transport permease protein
COW1_RS06995	COG1129	ABC transporter
COW1_RS07000	COG1129	ABC transporter
COW1_RS07000	COG0842	Transport permease protein
COW1_RS07005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
COW1_RS07030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
COW1_RS07080	COG0640	Transcriptional regulator
COW1_RS07145	COG3549	Plasmid maintenance system killer
COW1_RS07150	COG0518	GMP synthase (glutamine-hydrolyzing) activity
COW1_RS07150	COG0519	Catalyzes the synthesis of GMP from XMP
COW1_RS07160	COG1570	exodeoxyribonuclease VII activity
COW1_RS07175	COG0167	dihydroorotate dehydrogenase activity
COW1_RS07180	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
COW1_RS07180	COG1013	pyruvate-flavodoxin oxidoreductase activity
COW1_RS07180	COG0674	pyruvate-flavodoxin oxidoreductase activity
COW1_RS07180	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
COW1_RS07190	COG4181	ATPase activity
COW1_RS07200	COG0659	secondary active sulfate transmembrane transporter activity
COW1_RS07205	COG1160	GTP binding
COW1_RS07220	COG0124	histidyl-tRNA synthetase
COW1_RS07235	COG0820	rRNA (adenine-C2-)-methyltransferase activity
COW1_RS07240	COG0105	UTP biosynthetic process
COW1_RS07250	COG1959	2 iron, 2 sulfur cluster binding
COW1_RS07275	COG1127	ABC transporter
COW1_RS07280	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
COW1_RS07285	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
COW1_RS07290	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
COW1_RS07295	COG1509	lysine 2,3-aminomutase activity
COW1_RS07310	COG5002	protein histidine kinase activity
COW1_RS07310	COG5001	Diguanylate cyclase
COW1_RS07320	COG0501	Belongs to the peptidase M48B family
COW1_RS07340	COG5001	Diguanylate cyclase
COW1_RS07385	COG1592	Rubrerythrin
COW1_RS07390	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
COW1_RS07425	COG1722	exodeoxyribonuclease VII activity
COW1_RS07430	COG0142	geranyltranstransferase activity
COW1_RS07435	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
COW1_RS07440	COG0720	synthase
COW1_RS07445	COG1469	GTP cyclohydrolase I activity
COW1_RS07455	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
COW1_RS07470	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
COW1_RS07485	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
COW1_RS07485	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
COW1_RS07490	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
COW1_RS07495	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
COW1_RS07505	COG0488	(ABC) transporter
COW1_RS07520	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
COW1_RS07525	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
COW1_RS07535	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
COW1_RS07540	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
COW1_RS07545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
COW1_RS07555	COG2716	regulation of RNA biosynthetic process
COW1_RS07560	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
COW1_RS07565	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
COW1_RS07580	COG0583	DNA-binding transcription factor activity
COW1_RS07595	COG0840	transmembrane signaling receptor activity
COW1_RS07615	COG2067	long-chain fatty acid transport protein
COW1_RS07620	COG0425	Belongs to the sulfur carrier protein TusA family
COW1_RS07625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
COW1_RS07630	COG4783	chaperone-mediated protein folding
COW1_RS07650	COG3258	Cytochrome c
COW1_RS07655	COG0737	Belongs to the 5'-nucleotidase family
COW1_RS07660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
COW1_RS07670	COG4771	TonB-dependent receptor
COW1_RS07690	COG4772	TonB-dependent receptor
COW1_RS07705	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
COW1_RS07710	COG0583	DNA-binding transcription factor activity
COW1_RS07720	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
COW1_RS07735	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
COW1_RS07740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
COW1_RS07745	COG4558	Periplasmic binding protein
COW1_RS07750	COG0748	coenzyme F420 binding
COW1_RS07760	COG4771	TonB-dependent receptor
COW1_RS07790	COG0783	Belongs to the Dps family
COW1_RS07795	COG0588	phosphoglycerate mutase activity
COW1_RS07850	COG1294	oxidase, subunit
COW1_RS07875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
COW1_RS07895	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
COW1_RS07900	COG0602	queuosine metabolic process
COW1_RS07905	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
COW1_RS07915	COG0823	Involved in the tonB-independent uptake of proteins
COW1_RS07935	COG0824	Thioesterase
COW1_RS07940	COG2255	four-way junction helicase activity
COW1_RS07945	COG0632	four-way junction helicase activity
COW1_RS07950	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
COW1_RS07955	COG0217	transcriptional regulatory protein
COW1_RS07965	COG0494	nUDIX hydrolase
COW1_RS07970	COG0741	lytic transglycosylase activity
COW1_RS07970	COG0739	heme binding
COW1_RS07970	COG1196	nuclear chromosome segregation
COW1_RS07975	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
COW1_RS07985	COG3002	Belongs to the UPF0753 family
COW1_RS07995	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
COW1_RS08030	COG0784	Response regulator, receiver
COW1_RS08030	COG2205	protein histidine kinase activity
COW1_RS08030	COG5002	protein histidine kinase activity
COW1_RS08035	COG0736	holo-[acyl-carrier-protein] synthase activity
COW1_RS08040	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
COW1_RS08045	COG1381	Involved in DNA repair and RecF pathway recombination
COW1_RS08050	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
COW1_RS08055	COG0571	ribonuclease III activity
COW1_RS08065	COG0681	Belongs to the peptidase S26 family
COW1_RS08070	COG0481	GTPase activity
COW1_RS08080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
COW1_RS08090	COG3026	antisigma factor binding
COW1_RS08110	COG1254	Belongs to the acylphosphatase family
COW1_RS08115	COG1566	PFAM secretion protein HlyD family protein
COW1_RS08130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
COW1_RS08150	COG1393	Belongs to the ArsC family
COW1_RS08170	COG0628	permease
COW1_RS08175	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
COW1_RS08185	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
COW1_RS08190	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
COW1_RS08200	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
COW1_RS08205	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
COW1_RS08210	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
COW1_RS08215	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
COW1_RS08220	COG0271	Belongs to the BolA IbaG family
COW1_RS08225	COG3113	response to antibiotic
COW1_RS08230	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
COW1_RS08235	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
COW1_RS08240	COG1127	ABC transporter
COW1_RS08265	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
COW1_RS08275	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
COW1_RS08280	COG1137	ATPase activity
COW1_RS08285	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
COW1_RS08305	COG1660	Displays ATPase and GTPase activities
COW1_RS08315	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
COW1_RS08320	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
COW1_RS08325	COG2239	Acts as a magnesium transporter
COW1_RS08335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
COW1_RS08340	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
COW1_RS08350	COG0312	modulator of DNA gyrase
COW1_RS08355	COG3028	Belongs to the UPF0307 family
COW1_RS08390	COG0312	modulator of DNA gyrase
COW1_RS08405	COG3164	Protein of unknown function
COW1_RS08410	COG1530	ribonuclease E activity
COW1_RS08420	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
COW1_RS08430	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
COW1_RS08435	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
COW1_RS08440	COG1466	dna polymerase III delta subunit
COW1_RS08450	COG0495	leucyl-tRNA aminoacylation
COW1_RS08465	COG0815	Transfers the fatty acyl group on membrane lipoproteins
COW1_RS08470	COG4535	Mg2 and Co2 transporter CorC
COW1_RS08475	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
COW1_RS08480	COG1702	phosphate starvation-inducible protein PhoH
COW1_RS08485	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
COW1_RS08500	COG0166	Belongs to the GPI family
COW1_RS08505	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
COW1_RS08510	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
COW1_RS08515	COG0297	glycogen (starch) synthase activity
COW1_RS08520	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
COW1_RS08530	COG0717	Belongs to the dCTP deaminase family
COW1_RS08535	COG0489	protein tyrosine kinase activity
COW1_RS08540	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
COW1_RS08540	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
COW1_RS08545	COG4657	Part of a membrane complex involved in electron transport
COW1_RS08550	COG2878	Part of a membrane complex involved in electron transport
COW1_RS08560	COG4658	electron transport chain
COW1_RS08565	COG4659	FMN binding
COW1_RS08570	COG4660	Part of a membrane complex involved in electron transport
COW1_RS08575	COG5001	Diguanylate cyclase
COW1_RS08575	COG5002	protein histidine kinase activity
COW1_RS08580	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
COW1_RS08590	COG3220	belongs to the UPF0276 family
COW1_RS08600	COG2259	Doxx family
COW1_RS08605	COG0248	Ppx GppA phosphatase
COW1_RS08625	COG0745	RESPONSE REGULATOR receiver
COW1_RS08645	COG3577	Aspartyl protease
COW1_RS08650	COG1115	amino acid carrier protein
COW1_RS08660	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
COW1_RS08710	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
COW1_RS08715	COG1116	anion transmembrane transporter activity
COW1_RS08720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
COW1_RS08725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
COW1_RS08730	COG3604	Transcriptional regulator
COW1_RS08755	COG0367	asparagine synthase
COW1_RS08760	COG0540	Belongs to the ATCase OTCase family
COW1_RS08770	COG1335	isochorismatase
COW1_RS08790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
COW1_RS08855	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
COW1_RS08865	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
COW1_RS08870	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
COW1_RS08875	COG0196	riboflavin kinase activity
COW1_RS08890	COG0268	Binds directly to 16S ribosomal RNA
COW1_RS08895	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
COW1_RS08900	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
COW1_RS08910	COG0261	This protein binds to 23S rRNA in the presence of protein L20
COW1_RS08915	COG0142	geranyltranstransferase activity
COW1_RS08925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
COW1_RS08930	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
COW1_RS08950	COG3209	COG3209 Rhs family protein
COW1_RS08955	COG3209	COG3209 Rhs family protein
COW1_RS08960	COG3209	COG3209 Rhs family protein
COW1_RS08970	COG3209	COG3209 Rhs family protein
COW1_RS08980	COG3209	COG3209 Rhs family protein
COW1_RS08985	COG3209	COG3209 Rhs family protein
COW1_RS09005	COG1704	LemA family
COW1_RS09025	COG1959	2 iron, 2 sulfur cluster binding
COW1_RS09030	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
COW1_RS09035	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
COW1_RS09065	COG0484	heat shock protein binding
COW1_RS09085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
COW1_RS09135	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
COW1_RS09140	COG1047	Peptidyl-prolyl cis-trans
COW1_RS09145	COG3842	ATPase activity
COW1_RS09150	COG1178	ABC-type Fe3 transport system permease component
COW1_RS09155	COG1840	ABC-type Fe3 transport system, periplasmic component
COW1_RS09160	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
COW1_RS09165	COG0483	inositol monophosphate 1-phosphatase activity
COW1_RS09190	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
COW1_RS09195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
COW1_RS09205	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
COW1_RS09210	COG2020	methyltransferase activity
COW1_RS09220	COG1959	2 iron, 2 sulfur cluster binding
COW1_RS09235	COG0494	nUDIX hydrolase
COW1_RS09250	COG4772	TonB-dependent receptor
COW1_RS09255	COG2205	protein histidine kinase activity
COW1_RS09255	COG0745	RESPONSE REGULATOR receiver
COW1_RS09255	COG4191	Histidine kinase
COW1_RS09270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
COW1_RS09280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
COW1_RS09320	COG0406	alpha-ribazole phosphatase activity
COW1_RS09335	COG0129	dihydroxy-acid dehydratase activity
COW1_RS09340	COG0840	transmembrane signaling receptor activity
COW1_RS09345	COG0189	ligase activity
COW1_RS09370	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
COW1_RS09405	COG3031	protein transport across the cell outer membrane
COW1_RS09425	COG0151	Belongs to the GarS family
COW1_RS09430	COG0138	bifunctional purine biosynthesis protein purh
COW1_RS09435	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
COW1_RS09450	COG2264	protein methyltransferase activity
COW1_RS09455	COG0439	Biotin carboxylase
COW1_RS09465	COG0511	ligase activity, forming carbon-carbon bonds
COW1_RS09470	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
COW1_RS09520	COG4964	Belongs to the GSP D family
COW1_RS09545	COG2203	Gaf domain
COW1_RS09545	COG3706	GGDEF domain
COW1_RS09545	COG5001	Diguanylate cyclase
COW1_RS09545	COG4251	negative regulation of phosphorylation
COW1_RS09555	COG2197	response regulator
COW1_RS09630	COG0489	protein tyrosine kinase activity
COW1_RS09635	COG3267	Type II secretory pathway component ExeA
COW1_RS09635	COG3409	Peptidoglycan-binding domain 1 protein
COW1_RS09645	COG1218	3'(2'),5'-bisphosphate nucleotidase
COW1_RS09650	COG0494	nUDIX hydrolase
COW1_RS09655	COG1011	Hydrolase
COW1_RS09715	COG0352	thiamine-phosphate diphosphorylase activity
COW1_RS09720	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
COW1_RS09725	COG0586	Pfam SNARE associated Golgi protein
COW1_RS09740	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
COW1_RS09755	COG0563	adenylate kinase activity
COW1_RS09760	COG0205	6-phosphofructokinase activity
COW1_RS09765	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
COW1_RS09770	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
COW1_RS09780	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
COW1_RS09785	COG0315	cyclic pyranopterin monophosphate synthase activity
COW1_RS09810	COG1639	'signal transduction protein
COW1_RS09840	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
COW1_RS09845	COG3706	GGDEF domain
COW1_RS09855	COG1187	pseudouridine synthase activity
COW1_RS09865	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
COW1_RS09890	COG0488	(ABC) transporter
COW1_RS09900	COG1403	HNH endonuclease
COW1_RS09905	COG3360	Dodecin
COW1_RS09910	COG4572	Cation transport regulator
COW1_RS09915	COG0446	pyridine nucleotide-disulphide oxidoreductase
COW1_RS09935	COG0583	DNA-binding transcription factor activity
COW1_RS09940	COG0659	secondary active sulfate transmembrane transporter activity
COW1_RS09965	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
COW1_RS09970	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
COW1_RS09975	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
COW1_RS09980	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
COW1_RS10000	COG4451	ribulose bisphosphate carboxylase, small
COW1_RS10005	COG1850	ribulose-bisphosphate carboxylase activity
COW1_RS10010	COG2010	Cytochrome c
COW1_RS10015	COG0513	Belongs to the DEAD box helicase family
COW1_RS10035	COG1136	(ABC) transporter
COW1_RS10035	COG0577	efflux transmembrane transporter activity
COW1_RS10040	COG5001	Diguanylate cyclase
COW1_RS10040	COG3706	GGDEF domain
COW1_RS10040	COG2203	Gaf domain
COW1_RS10040	COG4251	negative regulation of phosphorylation
COW1_RS10045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
COW1_RS10060	COG0490	domain, Protein
COW1_RS10060	COG2985	domain, Protein
COW1_RS10080	COG1902	pentaerythritol trinitrate reductase activity
COW1_RS10090	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
COW1_RS10105	COG4176	ABC-type proline glycine betaine transport system permease component
COW1_RS10110	COG4175	Glycine betaine
COW1_RS10120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
COW1_RS10185	COG5001	Diguanylate cyclase
COW1_RS10230	COG0433	COG0433 Predicted ATPase
COW1_RS10260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
COW1_RS10290	COG2329	Antibiotic biosynthesis monooxygenase
COW1_RS10360	COG1970	mechanosensitive ion channel activity
COW1_RS10370	COG0425	Belongs to the sulfur carrier protein TusA family
COW1_RS10405	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
COW1_RS10415	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
COW1_RS10435	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
COW1_RS10445	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
COW1_RS10455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
COW1_RS10460	COG1538	Outer membrane efflux protein
COW1_RS10470	COG1519	Transferase
COW1_RS10475	COG1560	Kdo2-lipid A biosynthetic process
COW1_RS10525	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
COW1_RS10540	COG1595	DNA-templated transcription, initiation
COW1_RS10550	COG0459	protein refolding
COW1_RS10555	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
COW1_RS10565	COG1324	tolerance protein
COW1_RS10570	COG4232	protein-disulfide reductase activity
COW1_RS10575	COG2827	Endonuclease containing a URI domain
COW1_RS10580	COG2204	response regulator
COW1_RS10585	COG2205	protein histidine kinase activity
COW1_RS10585	COG2198	Histidine kinase
COW1_RS10585	COG0784	Response regulator, receiver
COW1_RS10595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
COW1_RS10605	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
COW1_RS10645	COG0297	glycogen (starch) synthase activity
COW1_RS10655	COG0110	maltose O-acetyltransferase activity
COW1_RS10740	COG0529	Catalyzes the synthesis of activated sulfate
COW1_RS10740	COG2046	Belongs to the sulfate adenylyltransferase family
COW1_RS10795	COG2189	Belongs to the N(4) N(6)-methyltransferase family
COW1_RS10920	COG5642	Protein of unknown function (DUF2384)
COW1_RS10935	COG0489	protein tyrosine kinase activity
COW1_RS10975	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
COW1_RS10980	COG1194	a g-specific adenine glycosylase
COW1_RS10985	COG2982	Protein involved in outer membrane biogenesis
COW1_RS10995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
COW1_RS11020	COG1022	Amp-dependent synthetase and ligase
COW1_RS11030	COG2022	thiamine diphosphate biosynthetic process
COW1_RS11035	COG0598	Magnesium transport protein CorA
COW1_RS11040	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
COW1_RS11040	COG3264	Mechanosensitive ion channel
COW1_RS11045	COG0220	tRNA (guanine-N7-)-methyltransferase activity
COW1_RS11050	COG3954	Phosphoribulokinase
COW1_RS11060	COG0667	Aldo Keto reductase
COW1_RS11070	COG1612	heme a metabolic process
COW1_RS11105	COG2204	response regulator
COW1_RS11110	COG3852	Histidine kinase
COW1_RS11145	COG2217	Heavy metal translocating P-type atpase
COW1_RS11150	COG2258	MOSC domain
COW1_RS11185	COG2132	Multicopper oxidase
COW1_RS11205	COG2801	Transposase and inactivated derivatives
COW1_RS11215	COG0697	spore germination
COW1_RS11220	COG2217	Heavy metal translocating P-type atpase
COW1_RS11250	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
COW1_RS11255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
COW1_RS11270	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
COW1_RS11275	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
COW1_RS11280	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
COW1_RS11305	COG2813	Specifically methylates the guanine in position
COW1_RS11330	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
COW1_RS11335	COG0243	molybdopterin cofactor binding
COW1_RS11340	COG0437	4 iron, 4 sulfur cluster binding
COW1_RS11345	COG3302	dmso reductase anchor subunit
COW1_RS11350	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
COW1_RS11355	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
COW1_RS11360	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
COW1_RS11365	COG3154	lipid carrier protein
COW1_RS11385	COG0826	peptidase U32
COW1_RS11390	COG0826	peptidase U32
COW1_RS11395	COG1242	4 iron, 4 sulfur cluster binding
COW1_RS11430	COG1845	cytochrome c oxidase, subunit III
COW1_RS11440	COG2010	Cytochrome c
COW1_RS11460	COG0535	radical SAM domain protein
COW1_RS11495	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
COW1_RS11495	COG1648	precorrin-2 dehydrogenase activity
COW1_RS11505	COG0730	response to heat
COW1_RS11510	COG1012	belongs to the aldehyde dehydrogenase family
COW1_RS11515	COG0741	lytic transglycosylase activity
COW1_RS11515	COG0739	heme binding
COW1_RS11515	COG1196	nuclear chromosome segregation
COW1_RS11530	COG1320	monovalent cation:proton antiporter activity
COW1_RS11545	COG0651	ATP synthesis coupled electron transport
COW1_RS11550	COG0651	ATP synthesis coupled electron transport
COW1_RS11555	COG0651	ATP synthesis coupled electron transport
COW1_RS11565	COG0617	tRNA 3'-terminal CCA addition
COW1_RS11575	COG1968	undecaprenyl-diphosphatase activity
COW1_RS11590	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
COW1_RS11595	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
COW1_RS11605	COG0828	Belongs to the bacterial ribosomal protein bS21 family
COW1_RS11610	COG1610	YqeY-like protein
COW1_RS11615	COG0358	DNA primase activity
COW1_RS11625	COG1280	lysine exporter protein (LysE YggA)
COW1_RS11635	COG5642	Protein of unknown function (DUF2384)
COW1_RS11640	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
COW1_RS11665	COG4263	nitrous-oxide reductase activity
COW1_RS11670	COG0348	domain, Protein
COW1_RS11670	COG3901	Regulator of nitric oxide reductase transcription
COW1_RS11695	COG1278	Cold shock
COW1_RS11710	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
COW1_RS11720	COG2827	Endonuclease containing a URI domain
COW1_RS11735	COG3706	GGDEF domain
COW1_RS11770	COG0521	Mo-molybdopterin cofactor biosynthetic process
COW1_RS11815	COG1131	(ABC) transporter
COW1_RS11820	COG0842	Transport permease protein
COW1_RS11840	COG2010	Cytochrome c
COW1_RS11855	COG3278	Belongs to the heme-copper respiratory oxidase family
COW1_RS11860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
COW1_RS11865	COG0131	Imidazoleglycerol-phosphate dehydratase
COW1_RS11870	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
COW1_RS11875	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
COW1_RS11880	COG0107	imidazoleglycerol-phosphate synthase activity
COW1_RS11885	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
COW1_RS11890	COG0140	phosphoribosyl-ATP diphosphatase activity
COW1_RS11895	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
COW1_RS11900	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
COW1_RS11920	COG0435	Glutathione S-transferase
COW1_RS11945	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
COW1_RS11950	COG1333	cytochrome c biogenesis protein
COW1_RS11960	COG0218	Necessary for normal cell division and for the maintenance of normal septation
COW1_RS11970	COG1611	Belongs to the LOG family
COW1_RS12000	COG2922	Belongs to the Smg family
COW1_RS12005	COG0758	DNA mediated transformation
COW1_RS12015	COG0242	peptide deformylase activity
COW1_RS12020	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
COW1_RS12035	COG5000	phosphorelay sensor kinase activity
COW1_RS12040	COG2204	response regulator
COW1_RS12045	COG0569	domain protein
COW1_RS12050	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
COW1_RS12080	COG3189	MarR family transcriptional regulator
COW1_RS12090	COG0037	tRNA processing
COW1_RS12100	COG2210	Belongs to the sulfur carrier protein TusA family
COW1_RS12110	COG1490	D-aminoacyl-tRNA deacylase activity
COW1_RS12135	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
COW1_RS12145	COG0543	2 iron, 2 sulfur cluster binding
COW1_RS12145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
COW1_RS12165	COG0181	hydroxymethylbilane synthase activity
COW1_RS12180	COG2972	Histidine kinase
COW1_RS12180	COG0745	RESPONSE REGULATOR receiver
COW1_RS12185	COG0165	Argininosuccinate lyase
COW1_RS12190	COG5001	Diguanylate cyclase
COW1_RS12190	COG5002	protein histidine kinase activity
COW1_RS12225	COG1943	Transposase
COW1_RS12255	COG3706	GGDEF domain
COW1_RS12260	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
COW1_RS12280	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
COW1_RS12295	COG0583	DNA-binding transcription factor activity
COW1_RS12305	COG0730	response to heat
COW1_RS12325	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
COW1_RS12335	COG2861	carbohydrate metabolic process
COW1_RS12340	COG0793	Belongs to the peptidase S41A family
COW1_RS12345	COG4942	peptidase
COW1_RS12350	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
COW1_RS12360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
COW1_RS12365	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
COW1_RS12370	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
COW1_RS12375	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
COW1_RS12385	COG0606	chelatase, subunit chli
COW1_RS12395	COG0347	Belongs to the P(II) protein family
COW1_RS12400	COG0004	ammonium transporteR
COW1_RS12410	COG0009	L-threonylcarbamoyladenylate synthase
COW1_RS12415	COG3706	GGDEF domain
COW1_RS12425	COG1773	rubredoxin
COW1_RS12445	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
COW1_RS12460	COG4206	TonB-dependent receptor
COW1_RS12470	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
COW1_RS12475	COG0488	(ABC) transporter
COW1_RS12500	COG0438	transferase activity, transferring glycosyl groups
COW1_RS12505	COG0438	transferase activity, transferring glycosyl groups
COW1_RS12510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
COW1_RS12515	COG1509	lysine 2,3-aminomutase activity
COW1_RS12525	COG1846	Transcriptional regulator
COW1_RS12555	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
COW1_RS12570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
COW1_RS12575	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
COW1_RS12580	COG1047	Peptidyl-prolyl cis-trans
COW1_RS12585	COG0355	proton-transporting ATP synthase activity, rotational mechanism
COW1_RS12590	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
COW1_RS12595	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
COW1_RS12600	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
COW1_RS12605	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
COW1_RS12610	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
COW1_RS12620	COG0356	it plays a direct role in the translocation of protons across the membrane
COW1_RS12630	COG1475	DNA binding
COW1_RS12635	COG1192	Involved in chromosome partitioning
COW1_RS12640	COG0357	Ribosomal RNA small subunit methyltransferase G
COW1_RS12645	COG0445	tRNA wobble uridine modification
COW1_RS12660	COG0714	Associated with various cellular activities
COW1_RS12690	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
COW1_RS12695	COG0706	membrane insertase activity
COW1_RS12700	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
COW1_RS12705	COG0594	ribonuclease P activity
COW1_RS12710	COG0230	Belongs to the bacterial ribosomal protein bL34 family
COW1_RS12715	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
COW1_RS12725	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
COW1_RS12740	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
COW1_RS12750	COG0751	glycine-tRNA ligase activity
COW1_RS12755	COG0752	glycyl-tRNA synthetase alpha subunit
COW1_RS12765	COG0482	sulfurtransferase activity
COW1_RS12780	COG0174	glutamine synthetase
COW1_RS12795	COG3852	Histidine kinase
COW1_RS12800	COG2204	response regulator
COW1_RS12830	COG2165	general secretion pathway protein
COW1_RS12835	COG1459	type II secretion system
COW1_RS12840	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
COW1_RS12855	COG1450	Type ii and iii secretion system protein
COW1_RS12875	COG0167	dihydroorotate dehydrogenase activity
COW1_RS12880	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
COW1_RS12900	COG0210	DNA helicase
COW1_RS12940	COG4520	surface antigen
COW1_RS12955	COG3094	Invasion gene expression up-regulator, SirB
COW1_RS12970	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
COW1_RS12970	COG0543	2 iron, 2 sulfur cluster binding
COW1_RS12980	COG0672	)-iron permease
COW1_RS12990	COG0123	including yeast histone deacetylase and acetoin utilization protein
COW1_RS12995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
COW1_RS12995	COG1042	CoA-binding domain protein
COW1_RS12995	COG0045	succinate-CoA ligase (ADP-forming) activity
COW1_RS13010	COG0517	IMP dehydrogenase activity
COW1_RS13010	COG1125	glycine betaine transport
COW1_RS13015	COG0791	NLP P60 protein
COW1_RS13030	COG2703	oxygen carrier activity
COW1_RS13040	COG2943	transferase activity, transferring hexosyl groups
COW1_RS13050	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
COW1_RS13070	COG1671	Belongs to the UPF0178 family
COW1_RS13085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
COW1_RS13090	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
COW1_RS13100	COG3153	acetyltransferase
COW1_RS13105	COG3384	dioxygenase
COW1_RS13120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
COW1_RS13125	COG1129	ABC transporter
COW1_RS13125	COG0842	Transport permease protein
COW1_RS13130	COG0842	Transport permease protein
COW1_RS13145	COG0210	DNA helicase
COW1_RS13155	COG5002	protein histidine kinase activity
COW1_RS13155	COG5001	Diguanylate cyclase
COW1_RS13160	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
COW1_RS13165	COG1136	(ABC) transporter
COW1_RS13170	COG0390	transport system, permease component
COW1_RS13175	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
COW1_RS13180	COG1166	arginine decarboxylase activity
COW1_RS13185	COG2084	Dehydrogenase
COW1_RS13200	COG4772	TonB-dependent receptor
COW1_RS13210	COG0018	arginyl-trna synthetase
COW1_RS13215	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
COW1_RS13245	COG3001	Fructosamine kinase
COW1_RS13260	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
COW1_RS13270	COG0067	glutamate synthase
COW1_RS13270	COG0069	glutamate synthase activity
COW1_RS13270	COG0070	glutamate synthase
COW1_RS13285	COG0232	Belongs to the dGTPase family. Type 2 subfamily
COW1_RS13290	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
COW1_RS13295	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
COW1_RS13335	COG0281	malic enzyme
COW1_RS13350	COG0254	rRNA binding
COW1_RS13360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
COW1_RS13375	COG0635	Involved in the biosynthesis of porphyrin-containing compound
COW1_RS13380	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
COW1_RS13385	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
COW1_RS13390	COG0631	protein serine/threonine phosphatase activity
COW1_RS13395	COG2815	serine threonine protein kinase
COW1_RS13395	COG0515	serine threonine protein kinase
COW1_RS13400	COG1561	YicC-like family, N-terminal region
COW1_RS13405	COG0194	GDP metabolic process
COW1_RS13410	COG1758	RNA polymerase activity
COW1_RS13415	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
COW1_RS13425	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
COW1_RS13430	COG3161	chorismate lyase activity
COW1_RS13435	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
COW1_RS13455	COG1040	competence protein
COW1_RS13465	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
COW1_RS13470	COG0156	8-amino-7-oxononanoate synthase activity
COW1_RS13475	COG0596	Alpha beta hydrolase
COW1_RS13480	COG2226	methyltransferase
COW1_RS13500	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
COW1_RS13520	COG3346	SURF1 family
COW1_RS13530	COG0109	protoheme IX farnesyltransferase activity
COW1_RS13535	COG3278	Belongs to the heme-copper respiratory oxidase family
COW1_RS13550	COG2010	Cytochrome c
COW1_RS13555	COG0348	domain, Protein
COW1_RS13565	COG2217	Heavy metal translocating P-type atpase
COW1_RS13600	COG2801	Transposase and inactivated derivatives
COW1_RS13625	COG2801	Transposase and inactivated derivatives
COW1_RS13645	COG0450	alkyl hydroperoxide reductase
COW1_RS13650	COG0425	Belongs to the sulfur carrier protein TusA family
COW1_RS13655	COG2391	methyltransferase activity
COW1_RS13705	COG3852	Histidine kinase
COW1_RS13710	COG2204	response regulator
COW1_RS13730	COG1278	Cold shock
COW1_RS13735	COG0724	RNA recognition motif
COW1_RS13755	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
COW1_RS13780	COG2177	Part of the ABC transporter FtsEX involved in
COW1_RS13785	COG2884	Cell division ATP-binding protein ftsE
COW1_RS13790	COG0552	protein localization to endoplasmic reticulum
COW1_RS13795	COG0612	Peptidase, M16
COW1_RS13800	COG0612	Peptidase, M16
COW1_RS13810	COG0742	ribosomal rna small subunit methyltransferase
COW1_RS13815	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
COW1_RS13820	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
COW1_RS13835	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
COW1_RS13840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
COW1_RS13860	COG1131	(ABC) transporter
COW1_RS13870	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
COW1_RS13880	COG0267	Belongs to the bacterial ribosomal protein bL33 family
COW1_RS13885	COG0227	Belongs to the bacterial ribosomal protein bL28 family
COW1_RS13890	COG2003	Belongs to the UPF0758 family
COW1_RS13895	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
COW1_RS13900	COG0756	dUTP diphosphatase activity
COW1_RS13910	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
COW1_RS13925	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
COW1_RS13930	COG0708	Exodeoxyribonuclease III
COW1_RS13950	COG1872	DUF167
COW1_RS13995	COG0540	Belongs to the ATCase OTCase family
COW1_RS14005	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
COW1_RS14010	COG1678	Uncharacterized ACR, COG1678
COW1_RS14035	COG0189	ligase activity
COW1_RS14060	COG0840	transmembrane signaling receptor activity
COW1_RS14070	COG0643	Histidine kinase
COW1_RS14070	COG0784	Response regulator, receiver
COW1_RS14070	COG2198	Histidine kinase
COW1_RS14075	COG2201	protein-glutamate methylesterase activity
COW1_RS14085	COG0471	metal ion transport
COW1_RS14100	COG2204	response regulator
COW1_RS14110	COG1385	rRNA (uridine-N3-)-methyltransferase activity
COW1_RS14115	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
COW1_RS14120	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
COW1_RS14125	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
COW1_RS14140	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
COW1_RS14145	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
COW1_RS14150	COG0126	phosphoglycerate kinase activity
COW1_RS14155	COG0469	pyruvate kinase activity
COW1_RS14160	COG0191	fructose-bisphosphate aldolase activity
COW1_RS14175	COG0475	glutathione-regulated potassium exporter activity
COW1_RS14190	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
COW1_RS14255	COG0071	Belongs to the small heat shock protein (HSP20) family
COW1_RS14260	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
COW1_RS14285	COG3409	Peptidoglycan-binding domain 1 protein
COW1_RS14285	COG3267	Type II secretory pathway component ExeA
COW1_RS14310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
COW1_RS14325	COG1515	deoxyribonuclease V activity
COW1_RS14335	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
COW1_RS14355	COG0546	phosphoglycolate phosphatase activity
COW1_RS14365	COG0512	Glutamine amidotransferase of anthranilate synthase
COW1_RS14370	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
COW1_RS14375	COG0134	indole-3-glycerol-phosphate synthase activity
COW1_RS14385	COG1765	OsmC-like protein
COW1_RS14395	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
COW1_RS14400	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
COW1_RS14410	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
COW1_RS14415	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
COW1_RS14425	COG3047	cAMP biosynthetic process
COW1_RS14435	COG0247	lactate metabolic process
COW1_RS14440	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
COW1_RS14450	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
COW1_RS14465	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
COW1_RS14490	COG0006	proline dipeptidase activity
COW1_RS14495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
COW1_RS14500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
COW1_RS14510	COG0404	The glycine cleavage system catalyzes the degradation of glycine
COW1_RS14515	COG0509	glycine decarboxylation via glycine cleavage system
COW1_RS14520	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
COW1_RS14525	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
COW1_RS14530	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
COW1_RS14535	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
COW1_RS14540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
COW1_RS14555	COG1309	transcriptional regulator
COW1_RS14560	COG0425	Belongs to the sulfur carrier protein TusA family
COW1_RS14565	COG2824	Alkylphosphonate utilization operon protein PhnA
COW1_RS14570	COG1331	Highly conserved protein containing a thioredoxin domain
COW1_RS14575	COG0463	Glycosyl transferase, family 2
COW1_RS14605	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
COW1_RS14625	COG2967	ApaG domain
COW1_RS14630	COG0837	glucose binding
COW1_RS14635	COG0363	glucosamine-6-phosphate deaminase activity
COW1_RS14650	COG0589	response to stress
COW1_RS14660	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
COW1_RS14665	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
COW1_RS14670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
COW1_RS14675	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
COW1_RS14690	COG3178	'Phosphotransferase
COW1_RS14695	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
COW1_RS14725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
COW1_RS14750	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
COW1_RS14755	COG0321	lipoyl(octanoyl) transferase activity
COW1_RS14760	COG2921	Belongs to the UPF0250 family
COW1_RS14790	COG1686	Belongs to the peptidase S11 family
COW1_RS14800	COG2951	lytic endotransglycosylase activity
COW1_RS14805	COG0772	Belongs to the SEDS family
COW1_RS14810	COG0768	penicillin binding
COW1_RS14815	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
COW1_RS14820	COG1792	Involved in formation and maintenance of cell shape
COW1_RS14825	COG1077	Cell shape determining protein MreB Mrl
COW1_RS14830	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
COW1_RS14835	COG0154	amidase activity
COW1_RS14840	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
COW1_RS14850	COG3100	YcgL domain-containing protein
COW1_RS14850	COG0561	phosphatase activity
COW1_RS14855	COG3647	Membrane
COW1_RS14865	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
COW1_RS14875	COG2890	protein-(glutamine-N5) methyltransferase activity
COW1_RS14880	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
COW1_RS14885	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
COW1_RS14895	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
COW1_RS14900	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
COW1_RS14910	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
COW1_RS14915	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
COW1_RS14920	COG0193	aminoacyl-tRNA hydrolase activity
COW1_RS14925	COG0012	GTP binding
COW1_RS15045	COG0582	viral genome integration into host DNA
COW1_RS15050	COG1104	cysteine desulfurase activity
COW1_RS15060	COG2226	methyltransferase
COW1_RS15080	COG0647	UMP catabolic process
COW1_RS15130	COG1518	maintenance of DNA repeat elements
COW1_RS15130	COG1468	defense response to virus
COW1_RS15135	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
COW1_RS15140	COG2204	response regulator
COW1_RS15150	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
COW1_RS15175	COG1331	Highly conserved protein containing a thioredoxin domain
COW1_RS15185	COG1444	tRNA N-acetyltransferase activity
COW1_RS15195	COG2270	Major facilitator Superfamily
COW1_RS15205	COG1643	Atp-dependent helicase
COW1_RS15225	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
COW1_RS15265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
COW1_RS15280	COG0432	Pfam Uncharacterised protein family UPF0047
COW1_RS15290	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
COW1_RS15295	COG2096	Adenosyltransferase
COW1_RS15305	COG4206	TonB-dependent receptor
COW1_RS15315	COG1120	ATPase activity
COW1_RS15330	COG0494	nUDIX hydrolase
COW1_RS15335	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
COW1_RS15355	COG1981	membrane
COW1_RS15360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
COW1_RS15375	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
COW1_RS15390	COG0316	Belongs to the HesB IscA family
COW1_RS15405	COG0739	heme binding
COW1_RS15410	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
COW1_RS15450	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
COW1_RS15450	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
COW1_RS15455	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
COW1_RS15475	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
COW1_RS15480	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
COW1_RS15495	COG0004	ammonium transporteR
COW1_RS15500	COG0697	spore germination
COW1_RS15515	COG2738	Putative neutral zinc metallopeptidase
COW1_RS15550	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
COW1_RS15570	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
COW1_RS15575	COG0081	regulation of translation
COW1_RS15580	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
COW1_RS15585	COG0222	ribosome binding
COW1_RS15590	COG0085	RNA polymerase activity
COW1_RS15595	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
COW1_RS15600	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
COW1_RS15605	COG0049	tRNA binding
COW1_RS15610	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
COW1_RS15615	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
COW1_RS15635	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
COW1_RS15640	COG0081	regulation of translation
COW1_RS15645	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
COW1_RS15650	COG0222	ribosome binding
COW1_RS15655	COG0085	RNA polymerase activity
COW1_RS15660	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
COW1_RS15665	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
COW1_RS15670	COG0049	tRNA binding
COW1_RS15675	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
COW1_RS15680	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
COW1_RS15685	COG0051	transcription antitermination factor activity, RNA binding
COW1_RS15690	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
COW1_RS15695	COG0088	Forms part of the polypeptide exit tunnel
COW1_RS15700	COG0089	rRNA binding
COW1_RS15705	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
COW1_RS15710	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
COW1_RS15715	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
COW1_RS15720	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
COW1_RS15725	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
COW1_RS15730	COG0255	Belongs to the universal ribosomal protein uL29 family
COW1_RS15735	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
COW1_RS15740	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
COW1_RS15745	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
COW1_RS15750	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
COW1_RS15755	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
COW1_RS15760	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
COW1_RS15765	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
COW1_RS15770	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
COW1_RS15775	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
COW1_RS15780	COG1841	ribosomal large subunit assembly
COW1_RS15785	COG0200	Binds to the 23S rRNA
COW1_RS15790	COG0201	protein transport
COW1_RS15795	COG0257	Belongs to the bacterial ribosomal protein bL36 family
COW1_RS15800	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
COW1_RS15805	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
COW1_RS15810	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
COW1_RS15815	COG0202	RNA polymerase activity
COW1_RS15820	COG0203	ribosomal protein L17
COW1_RS15835	COG2814	Major facilitator Superfamily
COW1_RS15840	COG0629	single-stranded DNA binding
COW1_RS15850	COG2001	Belongs to the MraZ family
COW1_RS15855	COG0275	rRNA processing
COW1_RS15860	COG3116	cell division
COW1_RS15875	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
COW1_RS15880	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
COW1_RS15885	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
COW1_RS15890	COG0772	Belongs to the SEDS family
COW1_RS15895	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
COW1_RS15900	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
COW1_RS15905	COG0812	UDP-N-acetylmuramate dehydrogenase activity
COW1_RS15910	COG1181	Belongs to the D-alanine--D-alanine ligase family
COW1_RS15925	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
COW1_RS15930	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
COW1_RS15940	COG0739	heme binding
COW1_RS15945	COG0653	protein targeting
COW1_RS15955	COG0494	nUDIX hydrolase
COW1_RS15970	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
COW1_RS15975	COG0237	dephospho-CoA kinase activity
COW1_RS15980	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
COW1_RS16005	COG0438	transferase activity, transferring glycosyl groups
COW1_RS16040	COG0045	succinate-CoA ligase (ADP-forming) activity
COW1_RS16045	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
COW1_RS16065	COG0564	pseudouridine synthase activity
COW1_RS16080	COG3830	Belongs to the UPF0237 family
COW1_RS16085	COG0242	peptide deformylase activity
COW1_RS16095	COG0542	response to heat
COW1_RS16110	COG0300	oxidoreductase activity
COW1_RS16120	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
COW1_RS16125	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
COW1_RS16130	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
COW1_RS16135	COG1360	Flagellar Motor Protein
COW1_RS16165	COG5265	(ABC) transporter
COW1_RS16180	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
COW1_RS16185	COG0442	prolyl-tRNA aminoacylation
COW1_RS16195	COG0028	Belongs to the TPP enzyme family
COW1_RS16200	COG0440	acetolactate synthase activity
COW1_RS16205	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
COW1_RS16215	COG0688	phosphatidylethanolamine metabolic process
COW1_RS16220	COG1183	phosphatidylcholine synthase activity
COW1_RS16225	COG3437	response regulator, receiver
COW1_RS16250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
COW1_RS16255	COG1573	uracil-dna glycosylase
COW1_RS16265	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
COW1_RS16270	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
COW1_RS16295	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
COW1_RS16305	COG0525	valine-tRNA ligase activity
COW1_RS16315	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
COW1_RS16320	COG0795	lipopolysaccharide-transporting ATPase activity
COW1_RS16325	COG0795	lipopolysaccharide-transporting ATPase activity
COW1_RS16330	COG1714	RDD family
COW1_RS16355	COG0617	tRNA 3'-terminal CCA addition
COW1_RS16365	COG2255	four-way junction helicase activity
COW1_RS16370	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
COW1_RS16375	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
COW1_RS16380	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
COW1_RS16410	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
COW1_RS16420	COG0418	dihydroorotase activity
COW1_RS16425	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
COW1_RS16430	COG0508	dehydrogenase complex catalyzes the overall conversion of
COW1_RS16430	COG0022	dehydrogenase e1 component
COW1_RS16440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
COW1_RS16450	COG0137	argininosuccinate synthase activity
COW1_RS16465	COG0581	inorganic phosphate transmembrane transporter activity
COW1_RS16470	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
COW1_RS16480	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
COW1_RS16485	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
COW1_RS16505	COG0367	asparagine synthase
COW1_RS16510	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
COW1_RS16515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
COW1_RS16525	COG0723	plastoquinol--plastocyanin reductase activity
COW1_RS16530	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
COW1_RS16535	COG2857	Cytochrome c1
COW1_RS16540	COG0625	glutathione transferase activity
COW1_RS16545	COG2969	positive regulation of protein catabolic process
COW1_RS16585	COG3549	Plasmid maintenance system killer
COW1_RS16640	COG5002	protein histidine kinase activity
COW1_RS16645	COG3287	FIST C domain
COW1_RS16645	COG2200	EAL domain
COW1_RS16645	COG2199	diguanylate cyclase activity
COW1_RS16655	COG2823	Periplasmic or secreted lipoprotein
COW1_RS16660	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
COW1_RS16665	COG0792	nuclease activity
COW1_RS16680	COG0826	peptidase U32
COW1_RS16690	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
COW1_RS16690	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
COW1_RS16695	COG0802	atpase or kinase
COW1_RS16700	COG0860	N-Acetylmuramoyl-L-alanine amidase
COW1_RS16705	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
COW1_RS16710	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
COW1_RS16715	COG1923	regulation of RNA biosynthetic process
COW1_RS16720	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
COW1_RS16725	COG0330	HflC and HflK could
COW1_RS16730	COG0330	HflC and HflK could
COW1_RS16740	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
COW1_RS16745	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
COW1_RS16760	COG0557	exoribonuclease II activity
COW1_RS16765	COG2885	chlorophyll binding
COW1_RS16770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
COW1_RS16775	COG0360	Binds together with S18 to 16S ribosomal RNA
COW1_RS16780	COG2965	DNA replication, synthesis of RNA primer
COW1_RS16795	COG0359	binds to the 23S rRNA
COW1_RS16800	COG0305	Participates in initiation and elongation during chromosome replication
COW1_RS16805	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
COW1_RS16835	COG4536	flavin adenine dinucleotide binding
COW1_RS16840	COG4137	Cytochrome C assembly protein
COW1_RS16850	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
COW1_RS16855	COG0228	four-way junction DNA binding
COW1_RS16860	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
COW1_RS16865	COG0336	Belongs to the RNA methyltransferase TrmD family
COW1_RS16870	COG0335	large ribosomal subunit rRNA binding
COW1_RS16880	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
COW1_RS16885	COG0326	Molecular chaperone. Has ATPase activity
COW1_RS16890	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
COW1_RS16895	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
COW1_RS16900	COG0589	response to stress
COW1_RS16905	COG0659	secondary active sulfate transmembrane transporter activity
COW1_RS16940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
COW1_RS16945	COG2801	Transposase and inactivated derivatives