locus-tag	class	description
CFK21_RS00050	COG2391	methyltransferase activity
CFK21_RS00055	COG0425	Belongs to the sulfur carrier protein TusA family
CFK21_RS00060	COG0450	alkyl hydroperoxide reductase
CFK21_RS00090	COG2217	Heavy metal translocating P-type atpase
CFK21_RS00100	COG0348	domain, Protein
CFK21_RS00105	COG2010	Cytochrome c
CFK21_RS00120	COG3278	Belongs to the heme-copper respiratory oxidase family
CFK21_RS00125	COG0109	protoheme IX farnesyltransferase activity
CFK21_RS00135	COG3346	SURF1 family
CFK21_RS00155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CFK21_RS00175	COG2226	methyltransferase
CFK21_RS00180	COG0596	Alpha beta hydrolase
CFK21_RS00185	COG0156	8-amino-7-oxononanoate synthase activity
CFK21_RS00190	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CFK21_RS00200	COG1040	competence protein
CFK21_RS00220	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CFK21_RS00225	COG3161	chorismate lyase activity
CFK21_RS00230	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CFK21_RS00240	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CFK21_RS00245	COG1758	RNA polymerase activity
CFK21_RS00250	COG0194	GDP metabolic process
CFK21_RS00255	COG1561	YicC-like family, N-terminal region
CFK21_RS00260	COG0515	serine threonine protein kinase
CFK21_RS00260	COG2815	serine threonine protein kinase
CFK21_RS00265	COG0631	protein serine/threonine phosphatase activity
CFK21_RS00270	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CFK21_RS00275	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CFK21_RS00280	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CFK21_RS00295	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CFK21_RS00315	COG0281	malic enzyme
CFK21_RS00355	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CFK21_RS00360	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CFK21_RS00365	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CFK21_RS00380	COG0069	glutamate synthase activity
CFK21_RS00380	COG0070	glutamate synthase
CFK21_RS00380	COG0067	glutamate synthase
CFK21_RS00390	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CFK21_RS00405	COG3001	Fructosamine kinase
CFK21_RS00435	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CFK21_RS00440	COG0018	arginyl-trna synthetase
CFK21_RS00450	COG4772	TonB-dependent receptor
CFK21_RS00465	COG2084	Dehydrogenase
CFK21_RS00470	COG1166	arginine decarboxylase activity
CFK21_RS00475	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CFK21_RS00480	COG0390	transport system, permease component
CFK21_RS00485	COG1136	(ABC) transporter
CFK21_RS00490	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CFK21_RS00495	COG5001	Diguanylate cyclase
CFK21_RS00495	COG5002	protein histidine kinase activity
CFK21_RS00505	COG0210	DNA helicase
CFK21_RS00520	COG0842	Transport permease protein
CFK21_RS00525	COG1129	ABC transporter
CFK21_RS00525	COG0842	Transport permease protein
CFK21_RS00530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CFK21_RS00545	COG3384	dioxygenase
CFK21_RS00550	COG3153	acetyltransferase
CFK21_RS00560	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CFK21_RS00565	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CFK21_RS00580	COG1671	Belongs to the UPF0178 family
CFK21_RS00600	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CFK21_RS00610	COG2943	transferase activity, transferring hexosyl groups
CFK21_RS00620	COG2703	oxygen carrier activity
CFK21_RS00635	COG1388	LysM domain
CFK21_RS00635	COG0791	NLP P60 protein
CFK21_RS00640	COG1125	glycine betaine transport
CFK21_RS00640	COG0517	IMP dehydrogenase activity
CFK21_RS00655	COG1042	CoA-binding domain protein
CFK21_RS00655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFK21_RS00655	COG0045	succinate-CoA ligase (ADP-forming) activity
CFK21_RS00660	COG0123	including yeast histone deacetylase and acetoin utilization protein
CFK21_RS00670	COG0672	)-iron permease
CFK21_RS00680	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CFK21_RS00680	COG0543	2 iron, 2 sulfur cluster binding
CFK21_RS00695	COG3094	Invasion gene expression up-regulator, SirB
CFK21_RS00710	COG4520	surface antigen
CFK21_RS00730	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CFK21_RS00780	COG0210	DNA helicase
CFK21_RS00795	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CFK21_RS00800	COG0167	dihydroorotate dehydrogenase activity
CFK21_RS00820	COG1450	Type ii and iii secretion system protein
CFK21_RS00835	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CFK21_RS00840	COG1459	type II secretion system
CFK21_RS00845	COG2165	general secretion pathway protein
CFK21_RS00875	COG2204	response regulator
CFK21_RS00880	COG3852	Histidine kinase
CFK21_RS00890	COG0174	glutamine synthetase
CFK21_RS00905	COG0482	sulfurtransferase activity
CFK21_RS00915	COG0752	glycyl-tRNA synthetase alpha subunit
CFK21_RS00920	COG0751	glycine-tRNA ligase activity
CFK21_RS00930	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CFK21_RS00945	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CFK21_RS00955	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CFK21_RS00960	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CFK21_RS00965	COG0594	ribonuclease P activity
CFK21_RS00970	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CFK21_RS00975	COG0706	membrane insertase activity
CFK21_RS00980	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CFK21_RS00985	COG0582	viral genome integration into host DNA
CFK21_RS01005	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CFK21_RS01055	COG0714	Associated with various cellular activities
CFK21_RS01070	COG0445	tRNA wobble uridine modification
CFK21_RS01075	COG0357	Ribosomal RNA small subunit methyltransferase G
CFK21_RS01080	COG1192	Involved in chromosome partitioning
CFK21_RS01085	COG1475	DNA binding
CFK21_RS01095	COG0356	it plays a direct role in the translocation of protons across the membrane
CFK21_RS01105	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CFK21_RS01110	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CFK21_RS01115	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CFK21_RS01120	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CFK21_RS01125	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CFK21_RS01130	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CFK21_RS01135	COG1047	Peptidyl-prolyl cis-trans
CFK21_RS01140	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CFK21_RS01145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CFK21_RS01150	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CFK21_RS01220	COG1846	Transcriptional regulator
CFK21_RS01230	COG1509	lysine 2,3-aminomutase activity
CFK21_RS01235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CFK21_RS01240	COG0438	transferase activity, transferring glycosyl groups
CFK21_RS01245	COG0438	transferase activity, transferring glycosyl groups
CFK21_RS01270	COG0488	(ABC) transporter
CFK21_RS01275	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CFK21_RS01285	COG4206	TonB-dependent receptor
CFK21_RS01300	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CFK21_RS01320	COG1773	rubredoxin
CFK21_RS01330	COG3706	GGDEF domain
CFK21_RS01335	COG0009	L-threonylcarbamoyladenylate synthase
CFK21_RS01345	COG0004	ammonium transporteR
CFK21_RS01350	COG0347	Belongs to the P(II) protein family
CFK21_RS01360	COG0606	chelatase, subunit chli
CFK21_RS01370	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CFK21_RS01375	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CFK21_RS01380	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CFK21_RS01385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CFK21_RS01395	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CFK21_RS01400	COG4942	peptidase
CFK21_RS01405	COG0793	Belongs to the peptidase S41A family
CFK21_RS01410	COG2861	carbohydrate metabolic process
CFK21_RS01420	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CFK21_RS01440	COG0730	response to heat
CFK21_RS01450	COG0583	DNA-binding transcription factor activity
CFK21_RS01460	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CFK21_RS01480	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CFK21_RS01485	COG3706	GGDEF domain
CFK21_RS01510	COG1943	Transposase
CFK21_RS01540	COG5001	Diguanylate cyclase
CFK21_RS01540	COG5002	protein histidine kinase activity
CFK21_RS01545	COG0165	Argininosuccinate lyase
CFK21_RS01550	COG0745	RESPONSE REGULATOR receiver
CFK21_RS01550	COG2972	Histidine kinase
CFK21_RS01565	COG0181	hydroxymethylbilane synthase activity
CFK21_RS01585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CFK21_RS01585	COG0543	2 iron, 2 sulfur cluster binding
CFK21_RS01595	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CFK21_RS01620	COG1490	D-aminoacyl-tRNA deacylase activity
CFK21_RS01630	COG2210	Belongs to the sulfur carrier protein TusA family
CFK21_RS01640	COG0037	tRNA processing
CFK21_RS01650	COG3189	MarR family transcriptional regulator
CFK21_RS01680	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CFK21_RS01685	COG0569	domain protein
CFK21_RS01690	COG2204	response regulator
CFK21_RS01695	COG5000	phosphorelay sensor kinase activity
CFK21_RS01710	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CFK21_RS01715	COG0242	peptide deformylase activity
CFK21_RS01725	COG0758	DNA mediated transformation
CFK21_RS01730	COG2922	Belongs to the Smg family
CFK21_RS01760	COG1611	Belongs to the LOG family
CFK21_RS01770	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CFK21_RS01780	COG1333	cytochrome c biogenesis protein
CFK21_RS01785	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CFK21_RS01810	COG0435	Glutathione S-transferase
CFK21_RS01830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CFK21_RS01835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CFK21_RS01840	COG0140	phosphoribosyl-ATP diphosphatase activity
CFK21_RS01845	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CFK21_RS01850	COG0107	imidazoleglycerol-phosphate synthase activity
CFK21_RS01855	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CFK21_RS01860	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CFK21_RS01865	COG0131	Imidazoleglycerol-phosphate dehydratase
CFK21_RS01870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CFK21_RS01875	COG3278	Belongs to the heme-copper respiratory oxidase family
CFK21_RS01890	COG2010	Cytochrome c
CFK21_RS01910	COG0842	Transport permease protein
CFK21_RS01915	COG1131	(ABC) transporter
CFK21_RS01960	COG0521	Mo-molybdopterin cofactor biosynthetic process
CFK21_RS01970	COG0189	ligase activity
CFK21_RS01995	COG3706	GGDEF domain
CFK21_RS02010	COG2827	Endonuclease containing a URI domain
CFK21_RS02020	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CFK21_RS02035	COG1278	Cold shock
CFK21_RS02060	COG3901	Regulator of nitric oxide reductase transcription
CFK21_RS02060	COG0348	domain, Protein
CFK21_RS02065	COG4263	nitrous-oxide reductase activity
CFK21_RS02090	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CFK21_RS02095	COG5642	Protein of unknown function (DUF2384)
CFK21_RS02105	COG1280	lysine exporter protein (LysE YggA)
CFK21_RS02115	COG0358	DNA primase activity
CFK21_RS02120	COG1610	YqeY-like protein
CFK21_RS02125	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CFK21_RS02135	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CFK21_RS02140	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CFK21_RS02155	COG1968	undecaprenyl-diphosphatase activity
CFK21_RS02165	COG0617	tRNA 3'-terminal CCA addition
CFK21_RS02175	COG0651	ATP synthesis coupled electron transport
CFK21_RS02180	COG0651	ATP synthesis coupled electron transport
CFK21_RS02185	COG0651	ATP synthesis coupled electron transport
CFK21_RS02200	COG1320	monovalent cation:proton antiporter activity
CFK21_RS02215	COG0739	heme binding
CFK21_RS02215	COG0741	lytic transglycosylase activity
CFK21_RS02215	COG1196	nuclear chromosome segregation
CFK21_RS02220	COG1012	belongs to the aldehyde dehydrogenase family
CFK21_RS02225	COG0730	response to heat
CFK21_RS02235	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CFK21_RS02235	COG1648	precorrin-2 dehydrogenase activity
CFK21_RS02270	COG0535	radical SAM domain protein
CFK21_RS02290	COG2010	Cytochrome c
CFK21_RS02300	COG1845	cytochrome c oxidase, subunit III
CFK21_RS02335	COG1242	4 iron, 4 sulfur cluster binding
CFK21_RS02340	COG0826	peptidase U32
CFK21_RS02345	COG0826	peptidase U32
CFK21_RS02365	COG3154	lipid carrier protein
CFK21_RS02370	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CFK21_RS02375	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CFK21_RS02380	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CFK21_RS02385	COG3302	dmso reductase anchor subunit
CFK21_RS02390	COG0437	4 iron, 4 sulfur cluster binding
CFK21_RS02395	COG0243	molybdopterin cofactor binding
CFK21_RS02400	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CFK21_RS02425	COG2813	Specifically methylates the guanine in position
CFK21_RS02450	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CFK21_RS02455	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CFK21_RS02460	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CFK21_RS02480	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CFK21_RS02510	COG2217	Heavy metal translocating P-type atpase
CFK21_RS02515	COG0697	spore germination
CFK21_RS02540	COG2132	Multicopper oxidase
CFK21_RS02565	COG2239	Acts as a magnesium transporter
CFK21_RS02575	COG2258	MOSC domain
CFK21_RS02580	COG2217	Heavy metal translocating P-type atpase
CFK21_RS02620	COG3852	Histidine kinase
CFK21_RS02625	COG2204	response regulator
CFK21_RS02660	COG1612	heme a metabolic process
CFK21_RS02670	COG0667	Aldo Keto reductase
CFK21_RS02680	COG3954	Phosphoribulokinase
CFK21_RS02685	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CFK21_RS02690	COG3264	Mechanosensitive ion channel
CFK21_RS02690	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CFK21_RS02695	COG0598	Magnesium transport protein CorA
CFK21_RS02700	COG2022	thiamine diphosphate biosynthetic process
CFK21_RS02710	COG1022	Amp-dependent synthetase and ligase
CFK21_RS02740	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CFK21_RS02750	COG2982	Protein involved in outer membrane biogenesis
CFK21_RS02755	COG1194	a g-specific adenine glycosylase
CFK21_RS02760	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CFK21_RS02795	COG2046	Belongs to the sulfate adenylyltransferase family
CFK21_RS02795	COG0529	Catalyzes the synthesis of activated sulfate
CFK21_RS02860	COG0297	glycogen (starch) synthase activity
CFK21_RS02875	COG0297	glycogen (starch) synthase activity
CFK21_RS02885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CFK21_RS02895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CFK21_RS02905	COG2198	Histidine kinase
CFK21_RS02905	COG0784	Response regulator, receiver
CFK21_RS02905	COG2205	protein histidine kinase activity
CFK21_RS02910	COG2204	response regulator
CFK21_RS02915	COG2827	Endonuclease containing a URI domain
CFK21_RS02920	COG4232	protein-disulfide reductase activity
CFK21_RS02925	COG1324	tolerance protein
CFK21_RS02935	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CFK21_RS02940	COG0459	protein refolding
CFK21_RS02950	COG1595	DNA-templated transcription, initiation
CFK21_RS02960	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CFK21_RS03010	COG1560	Kdo2-lipid A biosynthetic process
CFK21_RS03015	COG1519	Transferase
CFK21_RS03025	COG1538	Outer membrane efflux protein
CFK21_RS03030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CFK21_RS03035	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CFK21_RS03045	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CFK21_RS03055	COG1192	Involved in chromosome partitioning
CFK21_RS03070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CFK21_RS03080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CFK21_RS03110	COG0425	Belongs to the sulfur carrier protein TusA family
CFK21_RS03125	COG1970	mechanosensitive ion channel activity
CFK21_RS03185	COG2329	Antibiotic biosynthesis monooxygenase
CFK21_RS03215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CFK21_RS03245	COG0433	COG0433 Predicted ATPase
CFK21_RS03350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFK21_RS03360	COG4175	Glycine betaine
CFK21_RS03365	COG4176	ABC-type proline glycine betaine transport system permease component
CFK21_RS03380	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CFK21_RS03390	COG1902	pentaerythritol trinitrate reductase activity
CFK21_RS03410	COG2985	domain, Protein
CFK21_RS03410	COG0490	domain, Protein
CFK21_RS03425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CFK21_RS03430	COG1136	(ABC) transporter
CFK21_RS03430	COG4591	ABC-type transport system involved in lipoprotein release permease component
CFK21_RS03450	COG0513	Belongs to the DEAD box helicase family
CFK21_RS03455	COG2010	Cytochrome c
CFK21_RS03460	COG1850	ribulose-bisphosphate carboxylase activity
CFK21_RS03465	COG4451	ribulose bisphosphate carboxylase, small
CFK21_RS03485	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CFK21_RS03490	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CFK21_RS03495	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CFK21_RS03500	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CFK21_RS03525	COG0659	secondary active sulfate transmembrane transporter activity
CFK21_RS03530	COG0583	DNA-binding transcription factor activity
CFK21_RS03545	COG2863	cytochrome
CFK21_RS03550	COG0446	pyridine nucleotide-disulphide oxidoreductase
CFK21_RS03555	COG4572	Cation transport regulator
CFK21_RS03560	COG3360	Dodecin
CFK21_RS03565	COG1403	HNH endonuclease
CFK21_RS03575	COG0488	(ABC) transporter
CFK21_RS03600	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CFK21_RS03610	COG1187	pseudouridine synthase activity
CFK21_RS03620	COG3706	GGDEF domain
CFK21_RS03625	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CFK21_RS03655	COG1639	'signal transduction protein
CFK21_RS03680	COG0315	cyclic pyranopterin monophosphate synthase activity
CFK21_RS03685	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CFK21_RS03695	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CFK21_RS03700	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CFK21_RS03705	COG0205	6-phosphofructokinase activity
CFK21_RS03710	COG0563	adenylate kinase activity
CFK21_RS03715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CFK21_RS03725	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CFK21_RS03740	COG0586	Pfam SNARE associated Golgi protein
CFK21_RS03745	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CFK21_RS03750	COG0352	thiamine-phosphate diphosphorylase activity
CFK21_RS03810	COG1011	Hydrolase
CFK21_RS03815	COG0494	nUDIX hydrolase
CFK21_RS03820	COG1218	3'(2'),5'-bisphosphate nucleotidase
CFK21_RS03830	COG3267	Type II secretory pathway component ExeA
CFK21_RS03830	COG3409	Peptidoglycan-binding domain 1 protein
CFK21_RS03835	COG0489	protein tyrosine kinase activity
CFK21_RS03870	COG0457	Tetratricopeptide repeat
CFK21_RS03875	COG4106	trans-aconitate 2-methyltransferase activity
CFK21_RS03890	COG0457	Tetratricopeptide repeat
CFK21_RS03895	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CFK21_RS03900	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CFK21_RS03905	COG0511	ligase activity, forming carbon-carbon bonds
CFK21_RS03915	COG0439	Biotin carboxylase
CFK21_RS03920	COG2264	protein methyltransferase activity
CFK21_RS03935	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CFK21_RS03940	COG0138	bifunctional purine biosynthesis protein purh
CFK21_RS03945	COG0151	Belongs to the GarS family
CFK21_RS03965	COG3031	protein transport across the cell outer membrane
CFK21_RS04000	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CFK21_RS04020	COG0189	ligase activity
CFK21_RS04025	COG0840	transmembrane signaling receptor activity
CFK21_RS04030	COG0129	dihydroxy-acid dehydratase activity
CFK21_RS04045	COG0406	alpha-ribazole phosphatase activity
CFK21_RS04080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CFK21_RS04090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CFK21_RS04105	COG0745	RESPONSE REGULATOR receiver
CFK21_RS04105	COG2205	protein histidine kinase activity
CFK21_RS04105	COG4191	Histidine kinase
CFK21_RS04110	COG4772	TonB-dependent receptor
CFK21_RS04125	COG0494	nUDIX hydrolase
CFK21_RS04140	COG1959	2 iron, 2 sulfur cluster binding
CFK21_RS04150	COG2020	methyltransferase activity
CFK21_RS04155	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CFK21_RS04165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CFK21_RS04170	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CFK21_RS04195	COG0483	inositol monophosphate 1-phosphatase activity
CFK21_RS04200	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CFK21_RS04205	COG1840	ABC-type Fe3 transport system, periplasmic component
CFK21_RS04210	COG1178	ABC-type Fe3 transport system permease component
CFK21_RS04215	COG3842	ATPase activity
CFK21_RS04220	COG1047	Peptidyl-prolyl cis-trans
CFK21_RS04225	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CFK21_RS04275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CFK21_RS04295	COG0484	heat shock protein binding
CFK21_RS04325	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CFK21_RS04330	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CFK21_RS04335	COG1959	2 iron, 2 sulfur cluster binding
CFK21_RS04355	COG1704	LemA family
CFK21_RS04365	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CFK21_RS04370	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CFK21_RS04380	COG0142	geranyltranstransferase activity
CFK21_RS04385	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CFK21_RS04395	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CFK21_RS04400	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CFK21_RS04405	COG0268	Binds directly to 16S ribosomal RNA
CFK21_RS04415	COG0196	riboflavin kinase activity
CFK21_RS04420	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CFK21_RS04425	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CFK21_RS04435	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CFK21_RS04500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CFK21_RS04520	COG1335	isochorismatase
CFK21_RS04530	COG0540	Belongs to the ATCase OTCase family
CFK21_RS04535	COG0367	asparagine synthase
CFK21_RS04555	COG3604	Transcriptional regulator
CFK21_RS04560	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CFK21_RS04565	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CFK21_RS04570	COG1116	anion transmembrane transporter activity
CFK21_RS04575	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
CFK21_RS04625	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CFK21_RS04635	COG1115	amino acid carrier protein
CFK21_RS04640	COG3577	Aspartyl protease
CFK21_RS04665	COG0745	RESPONSE REGULATOR receiver
CFK21_RS04685	COG0248	Ppx GppA phosphatase
CFK21_RS04690	COG2259	Doxx family
CFK21_RS04700	COG3220	belongs to the UPF0276 family
CFK21_RS04710	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CFK21_RS04715	COG5001	Diguanylate cyclase
CFK21_RS04715	COG5002	protein histidine kinase activity
CFK21_RS04720	COG4660	Part of a membrane complex involved in electron transport
CFK21_RS04725	COG4659	FMN binding
CFK21_RS04730	COG4658	electron transport chain
CFK21_RS04740	COG2878	Part of a membrane complex involved in electron transport
CFK21_RS04745	COG4657	Part of a membrane complex involved in electron transport
CFK21_RS04750	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CFK21_RS04750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CFK21_RS04755	COG0489	protein tyrosine kinase activity
CFK21_RS04760	COG0717	Belongs to the dCTP deaminase family
CFK21_RS04770	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CFK21_RS04775	COG0297	glycogen (starch) synthase activity
CFK21_RS04780	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CFK21_RS04785	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CFK21_RS04790	COG0166	Belongs to the GPI family
CFK21_RS04805	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CFK21_RS04810	COG1702	phosphate starvation-inducible protein PhoH
CFK21_RS04815	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CFK21_RS04820	COG4535	Mg2 and Co2 transporter CorC
CFK21_RS04825	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CFK21_RS04840	COG0495	leucyl-tRNA aminoacylation
CFK21_RS04850	COG1466	dna polymerase III delta subunit
CFK21_RS04855	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CFK21_RS04860	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CFK21_RS04870	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CFK21_RS04880	COG1530	ribonuclease E activity
CFK21_RS04885	COG3164	Protein of unknown function
CFK21_RS04900	COG0312	modulator of DNA gyrase
CFK21_RS04935	COG3028	Belongs to the UPF0307 family
CFK21_RS04940	COG0312	modulator of DNA gyrase
CFK21_RS04950	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
CFK21_RS04955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CFK21_RS04965	COG2239	Acts as a magnesium transporter
CFK21_RS04970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CFK21_RS04975	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFK21_RS04985	COG1660	Displays ATPase and GTPase activities
CFK21_RS05005	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CFK21_RS05010	COG1137	ATPase activity
CFK21_RS05015	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CFK21_RS05025	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CFK21_RS05050	COG1127	ABC transporter
CFK21_RS05055	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CFK21_RS05060	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CFK21_RS05065	COG3113	response to antibiotic
CFK21_RS05070	COG0271	Belongs to the BolA IbaG family
CFK21_RS05075	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CFK21_RS05080	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CFK21_RS05085	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CFK21_RS05090	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CFK21_RS05100	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CFK21_RS05105	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CFK21_RS05115	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CFK21_RS05120	COG0628	permease
CFK21_RS05140	COG1393	Belongs to the ArsC family
CFK21_RS05160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFK21_RS05175	COG1566	PFAM secretion protein HlyD family protein
CFK21_RS05180	COG1254	Belongs to the acylphosphatase family
CFK21_RS05200	COG3026	antisigma factor binding
CFK21_RS05210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CFK21_RS05220	COG0481	GTPase activity
CFK21_RS05225	COG0681	Belongs to the peptidase S26 family
CFK21_RS05235	COG0571	ribonuclease III activity
CFK21_RS05240	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CFK21_RS05250	COG1381	Involved in DNA repair and RecF pathway recombination
CFK21_RS05255	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CFK21_RS05260	COG0736	holo-[acyl-carrier-protein] synthase activity
CFK21_RS05265	COG2205	protein histidine kinase activity
CFK21_RS05265	COG5002	protein histidine kinase activity
CFK21_RS05265	COG0784	Response regulator, receiver
CFK21_RS05300	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CFK21_RS05310	COG3002	Belongs to the UPF0753 family
CFK21_RS05320	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CFK21_RS05325	COG0739	heme binding
CFK21_RS05325	COG1196	nuclear chromosome segregation
CFK21_RS05325	COG0741	lytic transglycosylase activity
CFK21_RS05330	COG0494	nUDIX hydrolase
CFK21_RS05340	COG0217	transcriptional regulatory protein
CFK21_RS05345	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CFK21_RS05350	COG0632	four-way junction helicase activity
CFK21_RS05355	COG2255	four-way junction helicase activity
CFK21_RS05360	COG0824	Thioesterase
CFK21_RS05380	COG0823	Involved in the tonB-independent uptake of proteins
CFK21_RS05390	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CFK21_RS05395	COG0602	queuosine metabolic process
CFK21_RS05400	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CFK21_RS05440	COG1294	oxidase, subunit
CFK21_RS05495	COG0588	phosphoglycerate mutase activity
CFK21_RS05500	COG0783	Belongs to the Dps family
CFK21_RS05530	COG4771	TonB-dependent receptor
CFK21_RS05540	COG0748	coenzyme F420 binding
CFK21_RS05545	COG4558	Periplasmic binding protein
CFK21_RS05550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFK21_RS05555	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CFK21_RS05570	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CFK21_RS05580	COG0583	DNA-binding transcription factor activity
CFK21_RS05585	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CFK21_RS05600	COG4772	TonB-dependent receptor
CFK21_RS05620	COG4771	TonB-dependent receptor
CFK21_RS05630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CFK21_RS05635	COG0737	Belongs to the 5'-nucleotidase family
CFK21_RS05640	COG3258	Cytochrome c
CFK21_RS05660	COG4783	chaperone-mediated protein folding
CFK21_RS05665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CFK21_RS05670	COG0425	Belongs to the sulfur carrier protein TusA family
CFK21_RS05675	COG2067	long-chain fatty acid transport protein
CFK21_RS05695	COG0840	transmembrane signaling receptor activity
CFK21_RS05710	COG0583	DNA-binding transcription factor activity
CFK21_RS05725	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CFK21_RS05730	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CFK21_RS05735	COG2716	regulation of RNA biosynthetic process
CFK21_RS05745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CFK21_RS05750	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CFK21_RS05755	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CFK21_RS05765	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CFK21_RS05775	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CFK21_RS05790	COG0488	(ABC) transporter
CFK21_RS05800	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CFK21_RS05805	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CFK21_RS05810	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CFK21_RS05810	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CFK21_RS05825	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CFK21_RS05840	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CFK21_RS05850	COG1469	GTP cyclohydrolase I activity
CFK21_RS05855	COG0720	synthase
CFK21_RS05860	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CFK21_RS05865	COG0142	geranyltranstransferase activity
CFK21_RS05870	COG1722	exodeoxyribonuclease VII activity
CFK21_RS05905	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CFK21_RS05910	COG1592	Rubrerythrin
CFK21_RS05945	COG3209	COG3209 Rhs family protein
CFK21_RS05965	COG0501	Belongs to the peptidase M48B family
CFK21_RS05975	COG5002	protein histidine kinase activity
CFK21_RS05975	COG5001	Diguanylate cyclase
CFK21_RS05990	COG1509	lysine 2,3-aminomutase activity
CFK21_RS05995	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CFK21_RS06000	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CFK21_RS06005	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CFK21_RS06010	COG1127	ABC transporter
CFK21_RS06035	COG1959	2 iron, 2 sulfur cluster binding
CFK21_RS06045	COG0105	UTP biosynthetic process
CFK21_RS06050	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CFK21_RS06065	COG0124	histidyl-tRNA synthetase
CFK21_RS06080	COG1160	GTP binding
CFK21_RS06085	COG0659	secondary active sulfate transmembrane transporter activity
CFK21_RS06095	COG4181	ATPase activity
CFK21_RS06105	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CFK21_RS06105	COG1013	pyruvate-flavodoxin oxidoreductase activity
CFK21_RS06105	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CFK21_RS06105	COG0674	pyruvate-flavodoxin oxidoreductase activity
CFK21_RS06110	COG0167	dihydroorotate dehydrogenase activity
CFK21_RS06125	COG1570	exodeoxyribonuclease VII activity
CFK21_RS06135	COG0519	Catalyzes the synthesis of GMP from XMP
CFK21_RS06135	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CFK21_RS06140	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CFK21_RS06165	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CFK21_RS06175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CFK21_RS06195	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CFK21_RS06205	COG0516	GMP reductase activity
CFK21_RS06205	COG0517	IMP dehydrogenase activity
CFK21_RS06210	COG2920	part of a sulfur-relay system
CFK21_RS06215	COG0583	DNA-binding transcription factor activity
CFK21_RS06240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CFK21_RS06245	COG0156	8-amino-7-oxononanoate synthase activity
CFK21_RS06265	COG1132	(ABC) transporter
CFK21_RS06290	COG0456	acetyltransferase
CFK21_RS06325	COG1597	lipid kinase activity
CFK21_RS06355	COG0848	biopolymer transport protein
CFK21_RS06365	COG0811	peptide transport
CFK21_RS06405	COG3258	Cytochrome c
CFK21_RS06410	COG2863	cytochrome
CFK21_RS06420	COG0517	IMP dehydrogenase activity
CFK21_RS06420	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CFK21_RS06420	COG0617	tRNA 3'-terminal CCA addition
CFK21_RS06425	COG2221	Nitrite and sulphite reductase 4Fe-4S
CFK21_RS06430	COG2221	Nitrite and sulphite reductase 4Fe-4S
CFK21_RS06435	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CFK21_RS06545	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CFK21_RS06580	COG1322	Protein conserved in bacteria
CFK21_RS06585	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CFK21_RS06590	COG0732	type I restriction modification DNA specificity domain
CFK21_RS06620	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CFK21_RS06630	COG2356	endonuclease I
CFK21_RS06680	COG5642	Protein of unknown function (DUF2384)
CFK21_RS06830	COG2308	Evidence 4 Homologs of previously reported genes of
CFK21_RS06840	COG1051	belongs to the nudix hydrolase family
CFK21_RS06850	COG1131	(ABC) transporter
CFK21_RS06860	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CFK21_RS06880	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CFK21_RS06895	COG0415	Belongs to the DNA photolyase family
CFK21_RS06905	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CFK21_RS06930	COG0784	Response regulator, receiver
CFK21_RS06930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFK21_RS06930	COG2205	protein histidine kinase activity
CFK21_RS06930	COG2198	Histidine kinase
CFK21_RS06950	COG1408	metallophosphoesterase
CFK21_RS06970	COG1366	Belongs to the anti-sigma-factor antagonist family
CFK21_RS06975	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CFK21_RS06980	COG1127	ABC transporter
CFK21_RS07000	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CFK21_RS07045	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
CFK21_RS07050	COG0835	chemotaxis
CFK21_RS07050	COG0784	Response regulator, receiver
CFK21_RS07055	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CFK21_RS07070	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CFK21_RS07090	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CFK21_RS07095	COG1706	bacterial-type flagellum-dependent cell motility
CFK21_RS07100	COG1705	Flagellar rod assembly protein muramidase FlgJ
CFK21_RS07100	COG3951	Flagellar rod assembly protein muramidase FlgJ
CFK21_RS07115	COG5001	Diguanylate cyclase
CFK21_RS07115	COG5002	protein histidine kinase activity
CFK21_RS07130	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CFK21_RS07160	COG1677	Flagellar hook-basal body complex protein FliE
CFK21_RS07175	COG1317	bacterial-type flagellum organization
CFK21_RS07215	COG0513	Belongs to the DEAD box helicase family
CFK21_RS07225	COG3122	Protein conserved in bacteria
CFK21_RS07255	COG1987	bacterial-type flagellum assembly
CFK21_RS07270	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CFK21_RS07295	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CFK21_RS07300	COG2198	Histidine kinase
CFK21_RS07300	COG0643	Histidine kinase
CFK21_RS07300	COG0784	Response regulator, receiver
CFK21_RS07305	COG2201	protein-glutamate methylesterase activity
CFK21_RS07310	COG1192	Involved in chromosome partitioning
CFK21_RS07320	COG0835	chemotaxis
CFK21_RS07340	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CFK21_RS07370	COG3885	ferrous iron binding
CFK21_RS07370	COG2078	PFAM AMMECR1 domain protein
CFK21_RS07375	COG1355	regulation of microtubule-based process
CFK21_RS07390	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CFK21_RS07395	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CFK21_RS07420	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CFK21_RS07425	COG0343	queuine tRNA-ribosyltransferase activity
CFK21_RS07430	COG1862	Preprotein translocase
CFK21_RS07435	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CFK21_RS07440	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CFK21_RS07465	COG0688	phosphatidylethanolamine metabolic process
CFK21_RS07495	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CFK21_RS07510	COG1830	Aldolase
CFK21_RS07515	COG5002	protein histidine kinase activity
CFK21_RS07515	COG5001	Diguanylate cyclase
CFK21_RS07530	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CFK21_RS07540	COG0473	3-isopropylmalate dehydrogenase activity
CFK21_RS07545	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CFK21_RS07575	COG0101	tRNA pseudouridine synthase activity
CFK21_RS07580	COG0135	phosphoribosylanthranilate isomerase activity
CFK21_RS07585	COG0133	tryptophan synthase activity
CFK21_RS07590	COG0159	tryptophan synthase activity
CFK21_RS07595	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CFK21_RS07600	COG0285	dihydrofolate synthase activity
CFK21_RS07630	COG2379	hydroxypyruvate reductase
CFK21_RS07635	COG2833	Protein of unknown function (DUF455)
CFK21_RS07650	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CFK21_RS07655	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CFK21_RS07660	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CFK21_RS07665	COG0215	cysteine-tRNA ligase activity
CFK21_RS07675	COG5002	protein histidine kinase activity
CFK21_RS07675	COG5001	Diguanylate cyclase
CFK21_RS07680	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CFK21_RS07710	COG0544	peptidyl-prolyl cis-trans isomerase activity
CFK21_RS07715	COG0740	serine-type endopeptidase activity
CFK21_RS07720	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CFK21_RS07725	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CFK21_RS07745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CFK21_RS07750	COG1301	dicarboxylic acid transport
CFK21_RS07765	COG0601	transmembrane transport
CFK21_RS07770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFK21_RS07775	COG4172	Belongs to the ABC transporter superfamily
CFK21_RS07780	COG1404	Belongs to the peptidase S8 family
CFK21_RS07785	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CFK21_RS07795	COG0429	hydrolase of the alpha beta-hydrolase fold
CFK21_RS07820	COG1278	Cold shock
CFK21_RS07840	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CFK21_RS07845	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CFK21_RS07890	COG1216	Glycosyl transferase, family 2
CFK21_RS07905	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CFK21_RS07915	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CFK21_RS07935	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CFK21_RS07955	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CFK21_RS07990	COG0640	Transcriptional regulator
CFK21_RS08000	COG0398	Pfam SNARE associated Golgi protein
CFK21_RS08020	COG2226	methyltransferase
CFK21_RS08035	COG0306	phosphate transporter
CFK21_RS08055	COG0450	alkyl hydroperoxide reductase
CFK21_RS08085	COG3706	GGDEF domain
CFK21_RS08090	COG2925	Exonuclease
CFK21_RS08115	COG1047	Peptidyl-prolyl cis-trans
CFK21_RS08180	COG0582	viral genome integration into host DNA
CFK21_RS08190	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CFK21_RS08195	COG0733	neurotransmitter:sodium symporter activity
CFK21_RS08205	COG2914	Belongs to the UPF0125 (RnfH) family
CFK21_RS08215	COG0735	belongs to the Fur family
CFK21_RS08225	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CFK21_RS08230	COG1420	regulation of RNA biosynthetic process
CFK21_RS08235	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CFK21_RS08240	COG0443	Heat shock 70 kDa protein
CFK21_RS08245	COG0484	heat shock protein binding
CFK21_RS08250	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CFK21_RS08255	COG0505	Belongs to the CarA family
CFK21_RS08260	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CFK21_RS08265	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CFK21_RS08280	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CFK21_RS08285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CFK21_RS08290	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CFK21_RS08295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CFK21_RS08300	COG0149	triose-phosphate isomerase activity
CFK21_RS08315	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CFK21_RS08320	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CFK21_RS08325	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CFK21_RS08330	COG0649	NAD binding
CFK21_RS08345	COG1034	ATP synthesis coupled electron transport
CFK21_RS08350	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CFK21_RS08355	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CFK21_RS08365	COG0713	ATP synthesis coupled electron transport
CFK21_RS08380	COG1007	ATP synthesis coupled electron transport
CFK21_RS08405	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CFK21_RS08410	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CFK21_RS08425	COG0563	adenylate kinase activity
CFK21_RS08430	COG0729	surface antigen
CFK21_RS08435	COG2911	Protein conserved in bacteria
CFK21_RS08455	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CFK21_RS08470	COG0789	Transcriptional regulator
CFK21_RS08475	COG4221	oxidoreductase activity
CFK21_RS08490	COG0471	metal ion transport
CFK21_RS08490	COG3273	potassium ion transport
CFK21_RS08505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CFK21_RS08515	COG0779	Required for maturation of 30S ribosomal subunits
CFK21_RS08520	COG0195	Participates in both transcription termination and antitermination
CFK21_RS08525	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CFK21_RS08530	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CFK21_RS08535	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CFK21_RS08540	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CFK21_RS08545	COG1185	polyribonucleotide nucleotidyltransferase activity
CFK21_RS08565	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CFK21_RS08575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CFK21_RS08590	COG0436	Aminotransferase
CFK21_RS08600	COG1070	Carbohydrate kinase
CFK21_RS08605	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CFK21_RS08610	COG1196	nuclear chromosome segregation
CFK21_RS08620	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CFK21_RS08635	COG1376	ErfK ybiS ycfS ynhG family protein
CFK21_RS08650	COG0579	oxidoreductase
CFK21_RS08655	COG0247	lactate metabolic process
CFK21_RS08660	COG0277	FAD linked oxidase domain protein
CFK21_RS08665	COG0277	FAD linked oxidase domain protein
CFK21_RS08670	COG0500	methyltransferase
CFK21_RS08685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CFK21_RS08700	COG1199	ATP-dependent helicase activity
CFK21_RS08725	COG2210	Belongs to the sulfur carrier protein TusA family
CFK21_RS08745	COG0446	pyridine nucleotide-disulphide oxidoreductase
CFK21_RS08760	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CFK21_RS08765	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CFK21_RS08765	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CFK21_RS08770	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CFK21_RS08775	COG2957	Belongs to the agmatine deiminase family
CFK21_RS08790	COG4591	ABC-type transport system involved in lipoprotein release permease component
CFK21_RS08795	COG1136	(ABC) transporter
CFK21_RS08805	COG2333	competence protein COMEC
CFK21_RS08805	COG0658	competence protein
CFK21_RS08810	COG0811	peptide transport
CFK21_RS08815	COG0848	biopolymer transport protein
CFK21_RS08820	COG1132	(ABC) transporter
CFK21_RS08825	COG1663	tetraacyldisaccharide 4'-kinase activity
CFK21_RS08830	COG2835	tetraacyldisaccharide 4'-kinase activity
CFK21_RS08835	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CFK21_RS08860	COG2203	Gaf domain
CFK21_RS08860	COG3706	GGDEF domain
CFK21_RS08860	COG5001	Diguanylate cyclase
CFK21_RS08860	COG4251	negative regulation of phosphorylation
CFK21_RS08875	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CFK21_RS08880	COG1530	ribonuclease E activity
CFK21_RS08885	COG0564	pseudouridine synthase activity
CFK21_RS08890	COG0546	phosphoglycolate phosphatase activity
CFK21_RS08905	COG0424	maF-like protein
CFK21_RS08910	COG0511	ligase activity, forming carbon-carbon bonds
CFK21_RS08910	COG5016	pyruvate
CFK21_RS08920	COG0439	Biotin carboxylase
CFK21_RS08930	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CFK21_RS08935	COG0416	fatty acid biosynthetic process
CFK21_RS08940	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CFK21_RS08945	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CFK21_RS08950	COG1028	Short-chain dehydrogenase reductase Sdr
CFK21_RS08955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CFK21_RS08960	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CFK21_RS08965	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CFK21_RS08970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CFK21_RS08975	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CFK21_RS08985	COG0372	Belongs to the citrate synthase family
CFK21_RS08995	COG3245	cytochrome
CFK21_RS09000	COG1187	pseudouridine synthase activity
CFK21_RS09005	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CFK21_RS09020	COG0084	hydrolase, TatD family'
CFK21_RS09035	COG1022	Amp-dependent synthetase and ligase
CFK21_RS09040	COG1024	Enoyl-CoA hydratase
CFK21_RS09040	COG1250	3-hydroxyacyl-CoA dehydrogenase
CFK21_RS09075	COG1921	L-seryl-tRNASec selenium transferase activity
CFK21_RS09080	COG3276	selenocysteine insertion sequence binding
CFK21_RS09115	COG3038	cytochrome b561
CFK21_RS09125	COG4067	protein conserved in archaea
CFK21_RS09125	COG0189	ligase activity
CFK21_RS09130	COG0189	ligase activity
CFK21_RS09150	COG2046	Belongs to the sulfate adenylyltransferase family
CFK21_RS09160	COG3174	membrane
CFK21_RS09170	COG0508	dehydrogenase complex catalyzes the overall conversion of
CFK21_RS09180	COG0668	transmembrane transport
CFK21_RS09200	COG2020	methyltransferase activity
CFK21_RS09220	COG3588	fructose-bisphosphate aldolase
CFK21_RS09245	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CFK21_RS09250	COG0322	excinuclease ABC activity
CFK21_RS09255	COG1573	uracil-dna glycosylase
CFK21_RS09300	COG2204	response regulator
CFK21_RS09355	COG0670	Belongs to the BI1 family
CFK21_RS09385	COG1404	Belongs to the peptidase S8 family
CFK21_RS09410	COG0456	acetyltransferase
CFK21_RS09415	COG0730	response to heat
CFK21_RS09420	COG3706	GGDEF domain
CFK21_RS09435	COG3128	pkhd-type hydroxylase
CFK21_RS09465	COG2221	Nitrite and sulphite reductase 4Fe-4S
CFK21_RS09470	COG2221	Nitrite and sulphite reductase 4Fe-4S
CFK21_RS09475	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CFK21_RS09480	COG2923	Belongs to the DsrF TusC family
CFK21_RS09490	COG2920	part of a sulfur-relay system
CFK21_RS09525	COG1797	cobyrinic acid a,c-diamide synthase activity
CFK21_RS09535	COG3850	Histidine kinase
CFK21_RS09540	COG2197	response regulator
CFK21_RS09555	COG1252	NADH dehydrogenase
CFK21_RS09570	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CFK21_RS09570	COG1648	precorrin-2 dehydrogenase activity
CFK21_RS09580	COG0308	aminopeptidase N
CFK21_RS09600	COG3706	GGDEF domain
CFK21_RS09610	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CFK21_RS09620	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CFK21_RS09625	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CFK21_RS09630	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CFK21_RS09635	COG1674	ftsk spoiiie
CFK21_RS09640	COG0686	Belongs to the AlaDH PNT family
CFK21_RS09645	COG0492	ferredoxin-NADP+ reductase activity
CFK21_RS09655	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CFK21_RS09660	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CFK21_RS09665	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CFK21_RS09670	COG0542	response to heat
CFK21_RS09675	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CFK21_RS09680	COG1278	Cold shock
CFK21_RS09705	COG2915	High frequency lysogenization protein hflD homolog
CFK21_RS09715	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CFK21_RS09750	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
CFK21_RS09780	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
CFK21_RS09790	COG2239	Acts as a magnesium transporter
CFK21_RS09805	COG0589	response to stress
CFK21_RS09825	COG1269	ATP hydrolysis coupled proton transport
CFK21_RS09845	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
CFK21_RS09850	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
CFK21_RS09875	COG3263	regulation of cellular component size
CFK21_RS09885	COG3108	Peptidase M15
CFK21_RS09895	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CFK21_RS09905	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CFK21_RS09915	COG0436	Aminotransferase
CFK21_RS09935	COG1238	metal cluster binding
CFK21_RS09940	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CFK21_RS09945	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CFK21_RS09950	COG1193	negative regulation of DNA recombination
CFK21_RS09955	COG0585	pseudouridine synthase activity
CFK21_RS09990	COG1943	Transposase
CFK21_RS10000	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CFK21_RS10005	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CFK21_RS10010	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CFK21_RS10015	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CFK21_RS10020	COG0148	phosphopyruvate hydratase activity
CFK21_RS10025	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CFK21_RS10030	COG0504	CTP synthase activity
CFK21_RS10040	COG0825	malonyl-CoA metabolic process
CFK21_RS10050	COG0577	efflux transmembrane transporter activity
CFK21_RS10050	COG1136	(ABC) transporter
CFK21_RS10055	COG0577	efflux transmembrane transporter activity
CFK21_RS10055	COG1136	(ABC) transporter
CFK21_RS10060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CFK21_RS10075	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CFK21_RS10080	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CFK21_RS10085	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CFK21_RS10090	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CFK21_RS10110	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CFK21_RS10115	COG0575	Belongs to the CDS family
CFK21_RS10120	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CFK21_RS10125	COG0233	cytoplasmic translational termination
CFK21_RS10130	COG0528	UMP kinase activity
CFK21_RS10135	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CFK21_RS10140	COG0052	Belongs to the universal ribosomal protein uS2 family
CFK21_RS10145	COG0024	Methionine aminopeptidase
CFK21_RS10150	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CFK21_RS10180	COG2171	N-acyltransferase activity
CFK21_RS10185	COG2111	Na H antiporter
CFK21_RS10185	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CFK21_RS10190	COG1006	Multisubunit Na H antiporter MnhC subunit
CFK21_RS10195	COG0651	ATP synthesis coupled electron transport
CFK21_RS10205	COG2212	antiporter activity
CFK21_RS10210	COG1320	monovalent cation:proton antiporter activity
CFK21_RS10235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CFK21_RS10240	COG2133	pyrroloquinoline quinone binding
CFK21_RS10255	COG0798	PFAM Bile acid sodium symporter
CFK21_RS10260	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CFK21_RS10265	COG0640	Transcriptional regulator
CFK21_RS10275	COG1393	Belongs to the ArsC family
CFK21_RS10280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CFK21_RS10315	COG2983	Belongs to the UPF0260 family
CFK21_RS10320	COG4106	trans-aconitate 2-methyltransferase activity
CFK21_RS10325	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CFK21_RS10330	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CFK21_RS10345	COG2161	toxin-antitoxin pair type II binding
CFK21_RS10365	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CFK21_RS10365	COG3153	acetyltransferase
CFK21_RS10370	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CFK21_RS10375	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CFK21_RS10380	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CFK21_RS10385	COG1752	Esterase of the alpha-beta hydrolase superfamily
CFK21_RS10390	COG0668	transmembrane transport
CFK21_RS10395	COG1472	Belongs to the glycosyl hydrolase 3 family
CFK21_RS10400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFK21_RS10405	COG0601	transmembrane transport
CFK21_RS10420	COG2954	triphosphatase activity
CFK21_RS10430	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CFK21_RS10435	COG1053	succinate dehydrogenase
CFK21_RS10440	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CFK21_RS10460	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CFK21_RS10470	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CFK21_RS10490	COG0776	regulation of translation
CFK21_RS10500	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CFK21_RS10505	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CFK21_RS10510	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CFK21_RS10515	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CFK21_RS10520	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CFK21_RS10530	COG1858	cytochrome C peroxidase
CFK21_RS10535	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CFK21_RS10550	COG0436	Aminotransferase
CFK21_RS10570	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CFK21_RS10575	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CFK21_RS10600	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CFK21_RS10615	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CFK21_RS10615	COG0662	Cupin 2, conserved barrel domain protein
CFK21_RS10620	COG1555	photosystem II stabilization
CFK21_RS10620	COG1596	polysaccharide export
CFK21_RS10625	COG0284	orotidine-5'-phosphate decarboxylase activity
CFK21_RS10630	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CFK21_RS10640	COG0776	regulation of translation
CFK21_RS10650	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CFK21_RS10655	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CFK21_RS10660	COG0287	Prephenate dehydrogenase
CFK21_RS10665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CFK21_RS10670	COG1605	Chorismate mutase
CFK21_RS10670	COG0077	Prephenate dehydratase
CFK21_RS10675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CFK21_RS10680	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CFK21_RS10690	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CFK21_RS10700	COG2885	chlorophyll binding
CFK21_RS10700	COG3047	cAMP biosynthetic process
CFK21_RS10705	COG0668	transmembrane transport
CFK21_RS10710	COG0402	S-adenosylhomocysteine deaminase activity
CFK21_RS10720	COG0546	phosphoglycolate phosphatase activity
CFK21_RS10725	COG1322	Protein conserved in bacteria
CFK21_RS10730	COG1562	ergosterol biosynthetic process
CFK21_RS10740	COG1233	COG1233 Phytoene dehydrogenase and related
CFK21_RS10745	COG1028	Short-chain dehydrogenase reductase Sdr
CFK21_RS10755	COG3706	GGDEF domain
CFK21_RS10765	COG1187	pseudouridine synthase activity
CFK21_RS10770	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CFK21_RS10780	COG0180	Tryptophanyl-tRNA synthetase
CFK21_RS10785	COG1994	Peptidase M50
CFK21_RS10790	COG0009	L-threonylcarbamoyladenylate synthase
CFK21_RS10795	COG0613	PHP domain protein
CFK21_RS10800	COG2917	probably involved in intracellular septation
CFK21_RS10805	COG2350	Protein conserved in bacteria
CFK21_RS10815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CFK21_RS10835	COG0084	hydrolase, TatD family'
CFK21_RS10840	COG3100	YcgL domain-containing protein
CFK21_RS10840	COG0561	phosphatase activity
CFK21_RS10855	COG0589	response to stress
CFK21_RS10875	COG2944	sequence-specific DNA binding
CFK21_RS10880	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
CFK21_RS10910	COG0732	type I restriction modification DNA specificity domain
CFK21_RS10985	COG1067	ATP-dependent peptidase activity
CFK21_RS10990	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CFK21_RS11005	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CFK21_RS11005	COG1796	DNA polymerase
CFK21_RS11010	COG0191	fructose-bisphosphate aldolase activity
CFK21_RS11020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CFK21_RS11040	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CFK21_RS11075	COG4251	negative regulation of phosphorylation
CFK21_RS11075	COG2203	Gaf domain
CFK21_RS11075	COG3706	GGDEF domain
CFK21_RS11075	COG5001	Diguanylate cyclase
CFK21_RS11085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFK21_RS11095	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CFK21_RS11105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CFK21_RS11120	COG1752	Esterase of the alpha-beta hydrolase superfamily
CFK21_RS11135	COG0543	2 iron, 2 sulfur cluster binding
CFK21_RS11145	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CFK21_RS11175	COG0298	carbon dioxide binding
CFK21_RS11180	COG0375	protein maturation
CFK21_RS11190	COG0409	Hydrogenase expression formation protein
CFK21_RS11220	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CFK21_RS11235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CFK21_RS11250	COG0457	Tetratricopeptide repeat
CFK21_RS11255	COG3119	arylsulfatase activity
CFK21_RS11265	COG0719	Fe-S assembly protein
CFK21_RS11270	COG0396	ATPase activity
CFK21_RS11275	COG0719	Fe-S assembly protein
CFK21_RS11280	COG2151	metal-sulfur cluster biosynthetic enzyme
CFK21_RS11285	COG0316	Belongs to the HesB IscA family
CFK21_RS11290	COG2166	iron-sulfur cluster assembly
CFK21_RS11300	COG0438	transferase activity, transferring glycosyl groups
CFK21_RS11335	COG0438	transferase activity, transferring glycosyl groups
CFK21_RS11340	COG0438	transferase activity, transferring glycosyl groups
CFK21_RS11345	COG0367	asparagine synthase
CFK21_RS11350	COG0438	transferase activity, transferring glycosyl groups
CFK21_RS11380	COG3267	Type II secretory pathway component ExeA
CFK21_RS11380	COG3409	Peptidoglycan-binding domain 1 protein
CFK21_RS11390	COG0489	protein tyrosine kinase activity
CFK21_RS11410	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CFK21_RS11435	COG2204	response regulator
CFK21_RS11440	COG2205	protein histidine kinase activity
CFK21_RS11445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CFK21_RS11470	COG0328	RNA-DNA hybrid ribonuclease activity
CFK21_RS11480	COG1388	LysM domain
CFK21_RS11480	COG0741	lytic transglycosylase activity
CFK21_RS11490	COG0746	molybdenum cofactor guanylyltransferase activity
CFK21_RS11495	COG3608	succinylglutamate desuccinylase aspartoacylase
CFK21_RS11495	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CFK21_RS11515	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CFK21_RS11530	COG0537	adenosine 5'-monophosphoramidase activity
CFK21_RS11535	COG0058	SHG alpha-glucan phosphorylase activity
CFK21_RS11570	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFK21_RS11590	COG5001	Diguanylate cyclase
CFK21_RS11590	COG3300	MHYT domain
CFK21_RS11605	COG1454	alcohol dehydrogenase
CFK21_RS11615	COG1959	2 iron, 2 sulfur cluster binding
CFK21_RS11625	COG0033	Phosphoglucomutase
CFK21_RS11635	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CFK21_RS11645	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CFK21_RS11650	COG0501	Belongs to the peptidase M48B family
CFK21_RS11660	COG2154	pterin-4-alpha-carbinolamine dehydratase
CFK21_RS11665	COG1162	GTPase activity
CFK21_RS11670	COG0537	adenosine 5'-monophosphoramidase activity
CFK21_RS11680	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CFK21_RS11685	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CFK21_RS11690	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CFK21_RS11715	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CFK21_RS11730	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CFK21_RS11755	COG3002	Belongs to the UPF0753 family
CFK21_RS11760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CFK21_RS11780	COG2081	HI0933 family
CFK21_RS11790	COG2205	protein histidine kinase activity
CFK21_RS11790	COG0784	Response regulator, receiver
CFK21_RS11790	COG2198	Histidine kinase
CFK21_RS11795	COG1024	Enoyl-CoA hydratase
CFK21_RS11800	COG3706	GGDEF domain
CFK21_RS11805	COG1234	tRNA 3'-trailer cleavage
CFK21_RS11830	COG0058	SHG alpha-glucan phosphorylase activity
CFK21_RS11840	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CFK21_RS11845	COG0527	aspartate kinase activity
CFK21_RS11850	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CFK21_RS11855	COG2137	regulation of response to DNA damage stimulus
CFK21_RS11860	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CFK21_RS11870	COG1546	Belongs to the CinA family
CFK21_RS11880	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CFK21_RS11915	COG2203	Gaf domain
CFK21_RS11915	COG5001	Diguanylate cyclase
CFK21_RS11915	COG3706	GGDEF domain
CFK21_RS11915	COG4251	negative regulation of phosphorylation
CFK21_RS11920	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CFK21_RS11930	COG1074	ATP-dependent DNA helicase activity
CFK21_RS11935	COG3118	belongs to the thioredoxin family
CFK21_RS11940	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CFK21_RS11950	COG0318	PFAM AMP-dependent synthetase and ligase
CFK21_RS11970	COG0746	molybdenum cofactor guanylyltransferase activity
CFK21_RS11975	COG1763	Mo-molybdopterin cofactor biosynthetic process
CFK21_RS11985	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CFK21_RS11990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFK21_RS12025	COG0659	secondary active sulfate transmembrane transporter activity
CFK21_RS12030	COG0589	response to stress
CFK21_RS12035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CFK21_RS12040	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CFK21_RS12045	COG0326	Molecular chaperone. Has ATPase activity
CFK21_RS12050	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CFK21_RS12060	COG0335	large ribosomal subunit rRNA binding
CFK21_RS12065	COG0336	Belongs to the RNA methyltransferase TrmD family
CFK21_RS12070	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CFK21_RS12075	COG0228	four-way junction DNA binding
CFK21_RS12080	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CFK21_RS12090	COG4137	Cytochrome C assembly protein
CFK21_RS12095	COG4536	flavin adenine dinucleotide binding
CFK21_RS12125	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CFK21_RS12130	COG0305	Participates in initiation and elongation during chromosome replication
CFK21_RS12135	COG0359	binds to the 23S rRNA
CFK21_RS12145	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CFK21_RS12150	COG2965	DNA replication, synthesis of RNA primer
CFK21_RS12155	COG0360	Binds together with S18 to 16S ribosomal RNA
CFK21_RS12160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CFK21_RS12165	COG2885	chlorophyll binding
CFK21_RS12170	COG0557	exoribonuclease II activity
CFK21_RS12185	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CFK21_RS12190	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CFK21_RS12200	COG0330	HflC and HflK could
CFK21_RS12205	COG0330	HflC and HflK could
CFK21_RS12210	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CFK21_RS12215	COG1923	regulation of RNA biosynthetic process
CFK21_RS12220	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CFK21_RS12225	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CFK21_RS12230	COG0860	N-Acetylmuramoyl-L-alanine amidase
CFK21_RS12235	COG0802	atpase or kinase
CFK21_RS12240	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CFK21_RS12240	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CFK21_RS12250	COG0826	peptidase U32
CFK21_RS12265	COG0792	nuclease activity
CFK21_RS12270	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CFK21_RS12275	COG2823	Periplasmic or secreted lipoprotein
CFK21_RS12280	COG2199	diguanylate cyclase activity
CFK21_RS12280	COG2200	EAL domain
CFK21_RS12280	COG3287	FIST C domain
CFK21_RS12285	COG5002	protein histidine kinase activity
CFK21_RS12335	COG3549	Plasmid maintenance system killer
CFK21_RS12340	COG2801	Transposase and inactivated derivatives
CFK21_RS12390	COG2969	positive regulation of protein catabolic process
CFK21_RS12395	COG0625	glutathione transferase activity
CFK21_RS12400	COG2857	Cytochrome c1
CFK21_RS12405	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CFK21_RS12410	COG0723	plastoquinol--plastocyanin reductase activity
CFK21_RS12420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CFK21_RS12425	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CFK21_RS12430	COG0367	asparagine synthase
CFK21_RS12450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CFK21_RS12455	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CFK21_RS12465	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CFK21_RS12470	COG0581	inorganic phosphate transmembrane transporter activity
CFK21_RS12485	COG0137	argininosuccinate synthase activity
CFK21_RS12495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CFK21_RS12500	COG0508	dehydrogenase complex catalyzes the overall conversion of
CFK21_RS12500	COG0022	dehydrogenase e1 component
CFK21_RS12505	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CFK21_RS12510	COG0418	dihydroorotase activity
CFK21_RS12520	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CFK21_RS12550	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CFK21_RS12555	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CFK21_RS12560	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CFK21_RS12565	COG2255	four-way junction helicase activity
CFK21_RS12575	COG0617	tRNA 3'-terminal CCA addition
CFK21_RS12600	COG1714	RDD family
CFK21_RS12605	COG0795	lipopolysaccharide-transporting ATPase activity
CFK21_RS12610	COG0795	lipopolysaccharide-transporting ATPase activity
CFK21_RS12615	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CFK21_RS12625	COG0525	valine-tRNA ligase activity
CFK21_RS12635	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CFK21_RS12660	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CFK21_RS12665	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CFK21_RS12675	COG1573	uracil-dna glycosylase
CFK21_RS12680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CFK21_RS12700	COG3437	response regulator, receiver
CFK21_RS12705	COG1183	phosphatidylcholine synthase activity
CFK21_RS12710	COG0688	phosphatidylethanolamine metabolic process
CFK21_RS12715	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CFK21_RS12720	COG0440	acetolactate synthase activity
CFK21_RS12725	COG0028	Belongs to the TPP enzyme family
CFK21_RS12735	COG0442	prolyl-tRNA aminoacylation
CFK21_RS12740	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CFK21_RS12755	COG5265	(ABC) transporter
CFK21_RS12785	COG1360	Flagellar Motor Protein
CFK21_RS12790	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CFK21_RS12795	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CFK21_RS12800	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CFK21_RS12810	COG0300	oxidoreductase activity
CFK21_RS12825	COG0542	response to heat
CFK21_RS12835	COG0242	peptide deformylase activity
CFK21_RS12840	COG3830	Belongs to the UPF0237 family
CFK21_RS12855	COG0564	pseudouridine synthase activity
CFK21_RS12875	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CFK21_RS12880	COG0045	succinate-CoA ligase (ADP-forming) activity
CFK21_RS12920	COG1216	Glycosyl transferase, family 2
CFK21_RS12935	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CFK21_RS12940	COG0237	dephospho-CoA kinase activity
CFK21_RS12945	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CFK21_RS12960	COG0494	nUDIX hydrolase
CFK21_RS12970	COG0653	protein targeting
CFK21_RS12975	COG0739	heme binding
CFK21_RS12985	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CFK21_RS12990	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CFK21_RS13005	COG1181	Belongs to the D-alanine--D-alanine ligase family
CFK21_RS13010	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CFK21_RS13015	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CFK21_RS13020	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CFK21_RS13025	COG0772	Belongs to the SEDS family
CFK21_RS13030	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CFK21_RS13035	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CFK21_RS13040	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CFK21_RS13055	COG3116	cell division
CFK21_RS13060	COG0275	rRNA processing
CFK21_RS13065	COG2001	Belongs to the MraZ family
CFK21_RS13075	COG0629	single-stranded DNA binding
CFK21_RS13080	COG2814	Major facilitator Superfamily
CFK21_RS13095	COG0203	ribosomal protein L17
CFK21_RS13100	COG0202	RNA polymerase activity
CFK21_RS13105	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CFK21_RS13110	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CFK21_RS13115	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CFK21_RS13120	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CFK21_RS13125	COG0201	protein transport
CFK21_RS13130	COG0200	Binds to the 23S rRNA
CFK21_RS13135	COG1841	ribosomal large subunit assembly
CFK21_RS13140	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CFK21_RS13145	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CFK21_RS13150	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CFK21_RS13155	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CFK21_RS13160	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CFK21_RS13165	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CFK21_RS13170	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CFK21_RS13175	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CFK21_RS13180	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CFK21_RS13185	COG0255	Belongs to the universal ribosomal protein uL29 family
CFK21_RS13190	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CFK21_RS13195	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CFK21_RS13200	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CFK21_RS13205	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CFK21_RS13210	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CFK21_RS13215	COG0089	rRNA binding
CFK21_RS13220	COG0088	Forms part of the polypeptide exit tunnel
CFK21_RS13225	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CFK21_RS13230	COG0051	transcription antitermination factor activity, RNA binding
CFK21_RS13235	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CFK21_RS13240	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CFK21_RS13245	COG0049	tRNA binding
CFK21_RS13250	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CFK21_RS13255	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CFK21_RS13260	COG0085	RNA polymerase activity
CFK21_RS13265	COG0222	ribosome binding
CFK21_RS13270	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CFK21_RS13275	COG0081	regulation of translation
CFK21_RS13280	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CFK21_RS13300	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CFK21_RS13335	COG2738	Putative neutral zinc metallopeptidase
CFK21_RS13350	COG0697	spore germination
CFK21_RS13355	COG0004	ammonium transporteR
CFK21_RS13370	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CFK21_RS13375	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CFK21_RS13395	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CFK21_RS13400	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CFK21_RS13400	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CFK21_RS13440	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CFK21_RS13445	COG0739	heme binding
CFK21_RS13460	COG0316	Belongs to the HesB IscA family
CFK21_RS13475	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CFK21_RS13490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFK21_RS13495	COG1981	membrane
CFK21_RS13520	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
CFK21_RS13525	COG0494	nUDIX hydrolase
CFK21_RS13540	COG1120	ATPase activity
CFK21_RS13550	COG4206	TonB-dependent receptor
CFK21_RS13560	COG2096	Adenosyltransferase
CFK21_RS13565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CFK21_RS13570	COG1492	cobalamin metabolic process
CFK21_RS13575	COG0432	Pfam Uncharacterised protein family UPF0047
CFK21_RS13590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFK21_RS13630	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CFK21_RS13650	COG1643	Atp-dependent helicase
CFK21_RS13660	COG2270	Major facilitator Superfamily
CFK21_RS13670	COG1444	tRNA N-acetyltransferase activity
CFK21_RS13685	COG1331	Highly conserved protein containing a thioredoxin domain
CFK21_RS13710	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CFK21_RS13720	COG2204	response regulator
CFK21_RS13725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CFK21_RS13730	COG1518	maintenance of DNA repeat elements
CFK21_RS13745	COG1857	crispr-associated protein
CFK21_RS13760	COG1203	CRISPR-associated helicase, Cas3
CFK21_RS13780	COG0647	UMP catabolic process
CFK21_RS13790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CFK21_RS13795	COG2226	methyltransferase
CFK21_RS13805	COG1104	cysteine desulfurase activity
CFK21_RS13815	COG0012	GTP binding
CFK21_RS13820	COG0193	aminoacyl-tRNA hydrolase activity
CFK21_RS13825	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CFK21_RS13830	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CFK21_RS13850	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CFK21_RS13855	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CFK21_RS13865	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CFK21_RS13870	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CFK21_RS13875	COG2890	protein-(glutamine-N5) methyltransferase activity
CFK21_RS13885	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CFK21_RS13895	COG3647	Membrane
CFK21_RS13900	COG0561	phosphatase activity
CFK21_RS13900	COG3100	YcgL domain-containing protein
CFK21_RS13910	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CFK21_RS13915	COG0154	amidase activity
CFK21_RS13920	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CFK21_RS13925	COG1077	Cell shape determining protein MreB Mrl
CFK21_RS13930	COG1792	Involved in formation and maintenance of cell shape
CFK21_RS13935	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CFK21_RS13940	COG0768	penicillin binding
CFK21_RS13945	COG0772	Belongs to the SEDS family
CFK21_RS13950	COG2951	lytic endotransglycosylase activity
CFK21_RS13960	COG1686	Belongs to the peptidase S11 family
CFK21_RS13990	COG2921	Belongs to the UPF0250 family
CFK21_RS13995	COG0321	lipoyl(octanoyl) transferase activity
CFK21_RS14000	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CFK21_RS14025	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CFK21_RS14030	COG3178	'Phosphotransferase
CFK21_RS14045	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CFK21_RS14050	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CFK21_RS14055	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CFK21_RS14060	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CFK21_RS14065	COG0589	response to stress
CFK21_RS14080	COG0363	glucosamine-6-phosphate deaminase activity
CFK21_RS14085	COG0837	glucose binding
CFK21_RS14090	COG2967	ApaG domain
CFK21_RS14110	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CFK21_RS14140	COG0463	Glycosyl transferase, family 2
CFK21_RS14145	COG1331	Highly conserved protein containing a thioredoxin domain
CFK21_RS14150	COG2824	Alkylphosphonate utilization operon protein PhnA
CFK21_RS14155	COG0425	Belongs to the sulfur carrier protein TusA family
CFK21_RS14160	COG1309	transcriptional regulator
CFK21_RS14175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CFK21_RS14180	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CFK21_RS14185	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CFK21_RS14190	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CFK21_RS14195	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CFK21_RS14200	COG0509	glycine decarboxylation via glycine cleavage system
CFK21_RS14205	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CFK21_RS14215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CFK21_RS14220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CFK21_RS14225	COG0006	proline dipeptidase activity
CFK21_RS14250	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CFK21_RS14265	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CFK21_RS14270	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CFK21_RS14275	COG0247	lactate metabolic process
CFK21_RS14285	COG3047	cAMP biosynthetic process
CFK21_RS14300	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CFK21_RS14305	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CFK21_RS14315	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CFK21_RS14320	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CFK21_RS14330	COG1765	OsmC-like protein
CFK21_RS14340	COG0134	indole-3-glycerol-phosphate synthase activity
CFK21_RS14345	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CFK21_RS14350	COG0512	Glutamine amidotransferase of anthranilate synthase
CFK21_RS14365	COG0546	phosphoglycolate phosphatase activity
CFK21_RS14385	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CFK21_RS14395	COG1515	deoxyribonuclease V activity
CFK21_RS14410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CFK21_RS14435	COG3409	Peptidoglycan-binding domain 1 protein
CFK21_RS14435	COG3267	Type II secretory pathway component ExeA
CFK21_RS14460	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CFK21_RS14465	COG0071	Belongs to the small heat shock protein (HSP20) family
CFK21_RS14530	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CFK21_RS14545	COG0475	glutathione-regulated potassium exporter activity
CFK21_RS14560	COG0191	fructose-bisphosphate aldolase activity
CFK21_RS14565	COG0469	pyruvate kinase activity
CFK21_RS14570	COG0126	phosphoglycerate kinase activity
CFK21_RS14575	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CFK21_RS14580	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CFK21_RS14595	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CFK21_RS14600	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CFK21_RS14605	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CFK21_RS14610	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CFK21_RS14620	COG2204	response regulator
CFK21_RS14635	COG0471	metal ion transport
CFK21_RS14645	COG2201	protein-glutamate methylesterase activity
CFK21_RS14650	COG2198	Histidine kinase
CFK21_RS14650	COG0784	Response regulator, receiver
CFK21_RS14650	COG0643	Histidine kinase
CFK21_RS14660	COG0840	transmembrane signaling receptor activity
CFK21_RS14685	COG0189	ligase activity
CFK21_RS14710	COG1678	Uncharacterized ACR, COG1678
CFK21_RS14715	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CFK21_RS14725	COG0540	Belongs to the ATCase OTCase family
CFK21_RS14770	COG1872	DUF167
CFK21_RS14790	COG0708	Exodeoxyribonuclease III
CFK21_RS14795	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CFK21_RS14810	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CFK21_RS14820	COG0756	dUTP diphosphatase activity
CFK21_RS14825	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CFK21_RS14830	COG2003	Belongs to the UPF0758 family
CFK21_RS14835	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CFK21_RS14840	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CFK21_RS14850	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CFK21_RS14860	COG1131	(ABC) transporter
CFK21_RS14880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CFK21_RS14885	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CFK21_RS14900	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CFK21_RS14905	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CFK21_RS14910	COG0742	ribosomal rna small subunit methyltransferase
CFK21_RS14920	COG0612	Peptidase, M16
CFK21_RS14925	COG0612	Peptidase, M16
CFK21_RS14930	COG0552	protein localization to endoplasmic reticulum
CFK21_RS14935	COG2884	Cell division ATP-binding protein ftsE
CFK21_RS14940	COG2177	Part of the ABC transporter FtsEX involved in
CFK21_RS14965	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CFK21_RS14985	COG0724	RNA recognition motif
CFK21_RS14990	COG1278	Cold shock
CFK21_RS15010	COG2204	response regulator
CFK21_RS15015	COG3852	Histidine kinase