locus-tag	class	description
D9T12_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D9T12_RS00010	COG0592	DNA-directed DNA polymerase activity
D9T12_RS00015	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D9T12_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D9T12_RS00025	COG0187	DNA topoisomerase II activity
D9T12_RS00035	COG2873	o-acetylhomoserine
D9T12_RS00040	COG1280	lysine exporter protein (LysE YggA)
D9T12_RS00055	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D9T12_RS00155	COG1091	dTDP-4-dehydrorhamnose reductase activity
D9T12_RS00170	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D9T12_RS00175	COG2111	Na H antiporter
D9T12_RS00175	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D9T12_RS00180	COG1006	Multisubunit Na H antiporter MnhC subunit
D9T12_RS00185	COG0651	ATP synthesis coupled electron transport
D9T12_RS00190	COG1863	multisubunit Na H antiporter MnhE subunit
D9T12_RS00195	COG2212	antiporter activity
D9T12_RS00200	COG1320	monovalent cation:proton antiporter activity
D9T12_RS00235	COG0408	coproporphyrinogen oxidase activity
D9T12_RS00250	COG0009	L-threonylcarbamoyladenylate synthase
D9T12_RS00255	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D9T12_RS00260	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D9T12_RS00260	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D9T12_RS00270	COG0840	transmembrane signaling receptor activity
D9T12_RS00275	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D9T12_RS00280	COG1333	cytochrome c biogenesis protein
D9T12_RS00285	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D9T12_RS00290	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D9T12_RS00300	COG0778	Nitroreductase
D9T12_RS00315	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D9T12_RS00325	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D9T12_RS00330	COG0697	spore germination
D9T12_RS00345	COG0737	Belongs to the 5'-nucleotidase family
D9T12_RS00360	COG1484	DNA-dependent DNA replication
D9T12_RS00380	COG2132	Multicopper oxidase
D9T12_RS00415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D9T12_RS00430	COG1403	HNH endonuclease
D9T12_RS00465	COG1595	DNA-templated transcription, initiation
D9T12_RS00475	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D9T12_RS00480	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D9T12_RS00485	COG0363	glucosamine-6-phosphate deaminase activity
D9T12_RS00505	COG0167	dihydroorotate dehydrogenase activity
D9T12_RS00515	COG0432	Pfam Uncharacterised protein family UPF0047
D9T12_RS00525	COG0339	signal peptide processing
D9T12_RS00535	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D9T12_RS00540	COG1741	Belongs to the pirin family
D9T12_RS00560	COG1309	transcriptional regulator
D9T12_RS00575	COG3852	Histidine kinase
D9T12_RS00625	COG2304	oxidoreductase activity
D9T12_RS00645	COG0714	Associated with various cellular activities
D9T12_RS00650	COG2363	Small membrane protein
D9T12_RS00675	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D9T12_RS00700	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
D9T12_RS00715	COG1858	cytochrome C peroxidase
D9T12_RS00720	COG1858	cytochrome C peroxidase
D9T12_RS00755	COG2226	methyltransferase
D9T12_RS00760	COG0500	methyltransferase
D9T12_RS00765	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D9T12_RS00775	COG0714	Associated with various cellular activities
D9T12_RS00820	COG3118	belongs to the thioredoxin family
D9T12_RS00845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D9T12_RS00850	COG0165	Argininosuccinate lyase
D9T12_RS00860	COG0181	hydroxymethylbilane synthase activity
D9T12_RS00880	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
D9T12_RS00885	COG0543	2 iron, 2 sulfur cluster binding
D9T12_RS00885	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D9T12_RS00890	COG0708	Exodeoxyribonuclease III
D9T12_RS00900	COG0788	formyltetrahydrofolate deformylase activity
D9T12_RS00905	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D9T12_RS00910	COG2226	methyltransferase
D9T12_RS00915	COG0596	Alpha beta hydrolase
D9T12_RS00925	COG1115	amino acid carrier protein
D9T12_RS00940	COG2862	Uncharacterized protein family, UPF0114
D9T12_RS00950	COG3719	Belongs to the RNase T2 family
D9T12_RS00965	COG3706	GGDEF domain
D9T12_RS00970	COG0281	malic enzyme
D9T12_RS01000	COG0513	Belongs to the DEAD box helicase family
D9T12_RS01015	COG4628	conserved protein (DUF2132)
D9T12_RS01020	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D9T12_RS01035	COG0646	methionine synthase
D9T12_RS01035	COG1410	methionine synthase
D9T12_RS01045	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D9T12_RS01075	COG0840	transmembrane signaling receptor activity
D9T12_RS01090	COG0037	tRNA processing
D9T12_RS01105	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D9T12_RS01110	COG0569	domain protein
D9T12_RS01115	COG2204	response regulator
D9T12_RS01120	COG5000	phosphorelay sensor kinase activity
D9T12_RS01135	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D9T12_RS01140	COG0242	peptide deformylase activity
D9T12_RS01145	COG0758	DNA mediated transformation
D9T12_RS01160	COG0018	arginyl-trna synthetase
D9T12_RS01180	COG0606	chelatase, subunit chli
D9T12_RS01205	COG2813	Specifically methylates the guanine in position
D9T12_RS01225	COG0585	pseudouridine synthase activity
D9T12_RS01235	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D9T12_RS01260	COG1215	transferase activity, transferring glycosyl groups
D9T12_RS01270	COG1929	Belongs to the glycerate kinase type-1 family
D9T12_RS01280	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D9T12_RS01285	COG2199	diguanylate cyclase activity
D9T12_RS01285	COG2200	EAL domain
D9T12_RS01305	COG3100	YcgL domain-containing protein
D9T12_RS01315	COG0617	tRNA 3'-terminal CCA addition
D9T12_RS01340	COG1136	(ABC) transporter
D9T12_RS01340	COG0577	efflux transmembrane transporter activity
D9T12_RS01345	COG1136	(ABC) transporter
D9T12_RS01350	COG3706	GGDEF domain
D9T12_RS01370	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D9T12_RS01375	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D9T12_RS01380	COG0126	phosphoglycerate kinase activity
D9T12_RS01430	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
D9T12_RS01435	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
D9T12_RS01440	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
D9T12_RS01450	COG2154	pterin-4-alpha-carbinolamine dehydratase
D9T12_RS01465	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D9T12_RS01470	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
D9T12_RS01475	COG0583	DNA-binding transcription factor activity
D9T12_RS01500	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D9T12_RS01505	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D9T12_RS01515	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D9T12_RS01520	COG0546	phosphoglycolate phosphatase activity
D9T12_RS01535	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D9T12_RS01540	COG0438	transferase activity, transferring glycosyl groups
D9T12_RS01545	COG3100	YcgL domain-containing protein
D9T12_RS01545	COG0561	phosphatase activity
D9T12_RS01550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D9T12_RS01560	COG0134	indole-3-glycerol-phosphate synthase activity
D9T12_RS01585	COG2885	chlorophyll binding
D9T12_RS01595	COG4943	cyclic-guanylate-specific phosphodiesterase activity
D9T12_RS01605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9T12_RS01610	COG2197	response regulator
D9T12_RS01625	COG0189	ligase activity
D9T12_RS01635	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D9T12_RS01650	COG1765	OsmC-like protein
D9T12_RS01655	COG0667	Aldo Keto reductase
D9T12_RS01665	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D9T12_RS01675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D9T12_RS01685	COG0840	transmembrane signaling receptor activity
D9T12_RS01690	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D9T12_RS01720	COG1840	ABC-type Fe3 transport system, periplasmic component
D9T12_RS01725	COG1175	transmembrane transport
D9T12_RS01730	COG3842	ATPase activity
D9T12_RS01740	COG0564	pseudouridine synthase activity
D9T12_RS01765	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D9T12_RS01775	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D9T12_RS01785	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D9T12_RS01790	COG0081	regulation of translation
D9T12_RS01795	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D9T12_RS01800	COG0222	ribosome binding
D9T12_RS01805	COG0085	RNA polymerase activity
D9T12_RS01810	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D9T12_RS01815	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D9T12_RS01820	COG0049	tRNA binding
D9T12_RS01825	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D9T12_RS01830	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D9T12_RS01835	COG0051	transcription antitermination factor activity, RNA binding
D9T12_RS01840	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D9T12_RS01845	COG0088	Forms part of the polypeptide exit tunnel
D9T12_RS01850	COG0089	rRNA binding
D9T12_RS01855	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D9T12_RS01860	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D9T12_RS01865	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D9T12_RS01870	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D9T12_RS01875	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D9T12_RS01880	COG0255	Belongs to the universal ribosomal protein uL29 family
D9T12_RS01885	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D9T12_RS01890	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D9T12_RS01895	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D9T12_RS01900	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D9T12_RS01905	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D9T12_RS01910	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D9T12_RS01915	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D9T12_RS01920	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D9T12_RS01925	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D9T12_RS01930	COG1841	ribosomal large subunit assembly
D9T12_RS01935	COG0200	Binds to the 23S rRNA
D9T12_RS01940	COG0201	protein transport
D9T12_RS01945	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D9T12_RS01950	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D9T12_RS01955	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D9T12_RS01960	COG0202	RNA polymerase activity
D9T12_RS01965	COG0203	ribosomal protein L17
D9T12_RS01970	COG0084	hydrolase, TatD family'
D9T12_RS01975	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D9T12_RS01980	COG2205	protein histidine kinase activity
D9T12_RS02010	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D9T12_RS02035	COG2814	Major facilitator Superfamily
D9T12_RS02040	COG0629	single-stranded DNA binding
D9T12_RS02045	COG0840	transmembrane signaling receptor activity
D9T12_RS02050	COG2197	response regulator
D9T12_RS02060	COG0142	geranyltranstransferase activity
D9T12_RS02065	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D9T12_RS02070	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D9T12_RS02075	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D9T12_RS02080	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D9T12_RS02085	COG3437	response regulator, receiver
D9T12_RS02085	COG0784	Response regulator, receiver
D9T12_RS02090	COG4191	Histidine kinase
D9T12_RS02090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9T12_RS02095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9T12_RS02105	COG0563	adenylate kinase activity
D9T12_RS02110	COG3001	Fructosamine kinase
D9T12_RS02125	COG0840	transmembrane signaling receptor activity
D9T12_RS02125	COG0840	transmembrane signaling receptor activity
D9T12_RS02130	COG1561	YicC-like family, N-terminal region
D9T12_RS02135	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D9T12_RS02140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D9T12_RS02150	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D9T12_RS02160	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
D9T12_RS02165	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D9T12_RS02170	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D9T12_RS02175	COG0459	protein refolding
D9T12_RS02200	COG3300	MHYT domain
D9T12_RS02200	COG5001	Diguanylate cyclase
D9T12_RS02205	COG2200	EAL domain
D9T12_RS02210	COG3106	COG3106 Predicted ATPase
D9T12_RS02225	COG0788	formyltetrahydrofolate deformylase activity
D9T12_RS02240	COG0446	pyridine nucleotide-disulphide oxidoreductase
D9T12_RS02240	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D9T12_RS02255	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D9T12_RS02260	COG2218	PFAM glutamate synthase alpha subunit domain protein
D9T12_RS02265	COG0069	glutamate synthase activity
D9T12_RS02270	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D9T12_RS02275	COG0519	Catalyzes the synthesis of GMP from XMP
D9T12_RS02275	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D9T12_RS02285	COG0004	ammonium transporteR
D9T12_RS02300	COG0004	ammonium transporteR
D9T12_RS02305	COG0590	tRNA wobble adenosine to inosine editing
D9T12_RS02320	COG0415	Belongs to the DNA photolyase family
D9T12_RS02345	COG3046	protein related to deoxyribodipyrimidine photolyase
D9T12_RS02355	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D9T12_RS02360	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D9T12_RS02365	COG0259	pyridoxamine-phosphate oxidase activity
D9T12_RS02395	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D9T12_RS02405	COG0415	Belongs to the DNA photolyase family
D9T12_RS02410	COG0789	Transcriptional regulator
D9T12_RS02415	COG1366	Belongs to the anti-sigma-factor antagonist family
D9T12_RS02425	COG4191	Histidine kinase
D9T12_RS02430	COG2197	response regulator
D9T12_RS02445	COG3706	GGDEF domain
D9T12_RS02450	COG0509	glycine decarboxylation via glycine cleavage system
D9T12_RS02455	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D9T12_RS02475	COG0400	carboxylic ester hydrolase activity
D9T12_RS02500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D9T12_RS02500	COG2813	Specifically methylates the guanine in position
D9T12_RS02505	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D9T12_RS02545	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D9T12_RS02550	COG0540	Belongs to the ATCase OTCase family
D9T12_RS02555	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D9T12_RS02560	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D9T12_RS02565	COG1678	Uncharacterized ACR, COG1678
D9T12_RS02575	COG0189	ligase activity
D9T12_RS02590	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D9T12_RS02595	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D9T12_RS02600	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D9T12_RS02605	COG5001	Diguanylate cyclase
D9T12_RS02605	COG5002	protein histidine kinase activity
D9T12_RS02615	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D9T12_RS02630	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D9T12_RS02630	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D9T12_RS02635	COG1968	undecaprenyl-diphosphatase activity
D9T12_RS02655	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D9T12_RS02660	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D9T12_RS02665	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D9T12_RS02670	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D9T12_RS02675	COG1610	YqeY-like protein
D9T12_RS02690	COG0840	transmembrane signaling receptor activity
D9T12_RS02695	COG0446	pyridine nucleotide-disulphide oxidoreductase
D9T12_RS02700	COG2863	cytochrome
D9T12_RS02705	COG3005	denitrification pathway
D9T12_RS02720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9T12_RS02725	COG1138	Cytochrome C-type biogenesis protein
D9T12_RS02730	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
D9T12_RS02735	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D9T12_RS02740	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D9T12_RS02760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9T12_RS02770	COG1518	maintenance of DNA repeat elements
D9T12_RS02800	COG0138	bifunctional purine biosynthesis protein purh
D9T12_RS02810	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D9T12_RS02815	COG2264	protein methyltransferase activity
D9T12_RS02820	COG0439	Biotin carboxylase
D9T12_RS02825	COG0511	ligase activity, forming carbon-carbon bonds
D9T12_RS02830	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D9T12_RS02835	COG4232	protein-disulfide reductase activity
D9T12_RS02860	COG0640	Transcriptional regulator
D9T12_RS02865	COG0793	Belongs to the peptidase S41A family
D9T12_RS02870	COG0693	protein deglycase activity
D9T12_RS02885	COG1295	ribonuclease BN
D9T12_RS02890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9T12_RS02895	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D9T12_RS02930	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D9T12_RS02935	COG0659	secondary active sulfate transmembrane transporter activity
D9T12_RS02940	COG0564	pseudouridine synthase activity
D9T12_RS02945	COG0527	aspartate kinase activity
D9T12_RS02950	COG1917	Cupin 2, conserved barrel domain protein
D9T12_RS02955	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D9T12_RS02960	COG0456	acetyltransferase
D9T12_RS02975	COG0488	(ABC) transporter
D9T12_RS02980	COG2205	protein histidine kinase activity
D9T12_RS02985	COG0745	RESPONSE REGULATOR receiver
D9T12_RS02995	COG3038	cytochrome b561
D9T12_RS03000	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D9T12_RS03005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9T12_RS03010	COG0500	methyltransferase
D9T12_RS03015	COG3706	GGDEF domain
D9T12_RS03020	COG1011	Hydrolase
D9T12_RS03025	COG0494	nUDIX hydrolase
D9T12_RS03030	COG1218	3'(2'),5'-bisphosphate nucleotidase
D9T12_RS03040	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D9T12_RS03065	COG1858	cytochrome C peroxidase
D9T12_RS03090	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D9T12_RS03090	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D9T12_RS03100	COG2201	protein-glutamate methylesterase activity
D9T12_RS03115	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D9T12_RS03120	COG0343	queuine tRNA-ribosyltransferase activity
D9T12_RS03125	COG1862	Preprotein translocase
D9T12_RS03130	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D9T12_RS03135	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D9T12_RS03140	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D9T12_RS03155	COG2239	Acts as a magnesium transporter
D9T12_RS03165	COG1137	ATPase activity
D9T12_RS03180	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D9T12_RS03195	COG1127	ABC transporter
D9T12_RS03200	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D9T12_RS03205	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D9T12_RS03220	COG1131	(ABC) transporter
D9T12_RS03225	COG0842	Transport permease protein
D9T12_RS03235	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D9T12_RS03240	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D9T12_RS03245	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D9T12_RS03250	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D9T12_RS03255	COG0723	plastoquinol--plastocyanin reductase activity
D9T12_RS03260	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D9T12_RS03265	COG2857	Cytochrome c1
D9T12_RS03270	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D9T12_RS03285	COG0784	Response regulator, receiver
D9T12_RS03285	COG2198	Histidine kinase
D9T12_RS03285	COG2205	protein histidine kinase activity
D9T12_RS03290	COG0483	inositol monophosphate 1-phosphatase activity
D9T12_RS03295	COG4536	flavin adenine dinucleotide binding
D9T12_RS03305	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D9T12_RS03310	COG0228	four-way junction DNA binding
D9T12_RS03315	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D9T12_RS03320	COG0336	Belongs to the RNA methyltransferase TrmD family
D9T12_RS03325	COG0335	large ribosomal subunit rRNA binding
D9T12_RS03335	COG2205	protein histidine kinase activity
D9T12_RS03335	COG0784	Response regulator, receiver
D9T12_RS03345	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D9T12_RS03355	COG0525	valine-tRNA ligase activity
D9T12_RS03360	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D9T12_RS03380	COG0004	ammonium transporteR
D9T12_RS03385	COG0347	Belongs to the P(II) protein family
D9T12_RS03405	COG0174	glutamine synthetase
D9T12_RS03415	COG0581	inorganic phosphate transmembrane transporter activity
D9T12_RS03420	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D9T12_RS03435	COG5002	protein histidine kinase activity
D9T12_RS03440	COG0306	phosphate transporter
D9T12_RS03450	COG0840	transmembrane signaling receptor activity
D9T12_RS03455	COG0633	Ferredoxin
D9T12_RS03470	COG0271	Belongs to the BolA IbaG family
D9T12_RS03480	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D9T12_RS03485	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D9T12_RS03495	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D9T12_RS03500	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D9T12_RS03510	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D9T12_RS03515	COG1187	pseudouridine synthase activity
D9T12_RS03525	COG0850	regulation of cytokinetic process
D9T12_RS03530	COG2894	cell division
D9T12_RS03535	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D9T12_RS03540	COG3022	response to hydroperoxide
D9T12_RS03545	COG0625	glutathione transferase activity
D9T12_RS03550	COG2969	positive regulation of protein catabolic process
D9T12_RS03570	COG3425	synthase
D9T12_RS03575	COG1304	FMN binding
D9T12_RS03585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D9T12_RS03600	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D9T12_RS03610	COG2176	DNA-directed DNA polymerase activity
D9T12_RS03620	COG0564	pseudouridine synthase activity
D9T12_RS03635	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D9T12_RS03635	COG0574	Belongs to the PEP-utilizing enzyme family
D9T12_RS03640	COG2346	COG2346, Truncated hemoglobins
D9T12_RS03650	COG0792	nuclease activity
D9T12_RS03670	COG0742	ribosomal rna small subunit methyltransferase
D9T12_RS03690	COG2001	Belongs to the MraZ family
D9T12_RS03695	COG0275	rRNA processing
D9T12_RS03700	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D9T12_RS03720	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D9T12_RS03725	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D9T12_RS03730	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D9T12_RS03735	COG0772	Belongs to the SEDS family
D9T12_RS03740	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D9T12_RS03745	COG1028	Short-chain dehydrogenase reductase Sdr
D9T12_RS03750	COG0840	transmembrane signaling receptor activity
D9T12_RS03755	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D9T12_RS03760	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D9T12_RS03765	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D9T12_RS03780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D9T12_RS03785	COG1121	(ABC) transporter
D9T12_RS03800	COG0719	Fe-S assembly protein
D9T12_RS03805	COG0396	ATPase activity
D9T12_RS03810	COG0719	Fe-S assembly protein
D9T12_RS03815	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D9T12_RS03825	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D9T12_RS03830	COG1181	Belongs to the D-alanine--D-alanine ligase family
D9T12_RS03835	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D9T12_RS03845	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
D9T12_RS03855	COG0653	protein targeting
D9T12_RS03860	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D9T12_RS03865	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D9T12_RS03870	COG0352	thiamine-phosphate diphosphorylase activity
D9T12_RS03875	COG4999	Histidine kinase
D9T12_RS03875	COG3850	Histidine kinase
D9T12_RS03875	COG3437	response regulator, receiver
D9T12_RS03875	COG2205	protein histidine kinase activity
D9T12_RS03885	COG0367	asparagine synthase
D9T12_RS03890	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D9T12_RS03895	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D9T12_RS03905	COG0129	dihydroxy-acid dehydratase activity
D9T12_RS03935	COG4783	chaperone-mediated protein folding
D9T12_RS03940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D9T12_RS03940	COG0425	Belongs to the sulfur carrier protein TusA family
D9T12_RS03945	COG2210	Belongs to the sulfur carrier protein TusA family
D9T12_RS03950	COG1183	phosphatidylcholine synthase activity
D9T12_RS03955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D9T12_RS03965	COG0456	acetyltransferase
D9T12_RS03985	COG1959	2 iron, 2 sulfur cluster binding
D9T12_RS03990	COG0316	Belongs to the HesB IscA family
D9T12_RS03995	COG0105	UTP biosynthetic process
D9T12_RS04000	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D9T12_RS04010	COG0124	histidyl-tRNA synthetase
D9T12_RS04015	COG2976	Protein conserved in bacteria
D9T12_RS04020	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D9T12_RS04025	COG1160	GTP binding
D9T12_RS04050	COG1162	GTPase activity
D9T12_RS04055	COG2154	pterin-4-alpha-carbinolamine dehydratase
D9T12_RS04060	COG0501	Belongs to the peptidase M48B family
D9T12_RS04065	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D9T12_RS04070	COG0028	Belongs to the TPP enzyme family
D9T12_RS04080	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D9T12_RS04095	COG1074	ATP-dependent DNA helicase activity
D9T12_RS04115	COG0456	acetyltransferase
D9T12_RS04135	COG1278	Cold shock
D9T12_RS04145	COG0133	tryptophan synthase activity
D9T12_RS04175	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D9T12_RS04185	COG2863	cytochrome
D9T12_RS04190	COG0446	pyridine nucleotide-disulphide oxidoreductase
D9T12_RS04210	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D9T12_RS04240	COG4774	siderophore transport
D9T12_RS04250	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D9T12_RS04255	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D9T12_RS04260	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D9T12_RS04265	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D9T12_RS04270	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D9T12_RS04275	COG0072	phenylalanine-tRNA ligase activity
D9T12_RS04275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D9T12_RS04280	COG0776	regulation of translation
D9T12_RS04305	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D9T12_RS04310	COG4181	ATPase activity
D9T12_RS04320	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D9T12_RS04330	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D9T12_RS04335	COG0521	Mo-molybdopterin cofactor biosynthetic process
D9T12_RS04345	COG3338	carbonate dehydratase activity
D9T12_RS04355	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D9T12_RS04415	COG3123	guanosine phosphorylase activity
D9T12_RS04420	COG0659	secondary active sulfate transmembrane transporter activity
D9T12_RS04425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9T12_RS04445	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D9T12_RS04450	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D9T12_RS04450	COG1321	iron dependent repressor
D9T12_RS04455	COG1121	(ABC) transporter
D9T12_RS04460	COG0803	Belongs to the bacterial solute-binding protein 9 family
D9T12_RS04470	COG3706	GGDEF domain
D9T12_RS04475	COG0596	Alpha beta hydrolase
D9T12_RS04480	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D9T12_RS04540	COG3550	peptidyl-serine autophosphorylation
D9T12_RS04545	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D9T12_RS04550	COG0602	queuosine metabolic process
D9T12_RS04555	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D9T12_RS04560	COG0066	3-isopropylmalate dehydratase activity
D9T12_RS04565	COG0473	3-isopropylmalate dehydrogenase activity
D9T12_RS04570	COG0739	heme binding
D9T12_RS04580	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D9T12_RS04585	COG0101	tRNA pseudouridine synthase activity
D9T12_RS04590	COG0135	phosphoribosylanthranilate isomerase activity
D9T12_RS04600	COG0159	tryptophan synthase activity
D9T12_RS04605	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D9T12_RS04610	COG0285	dihydrofolate synthase activity
D9T12_RS04630	COG1534	Rna-binding protein
D9T12_RS04635	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D9T12_RS04645	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D9T12_RS04650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D9T12_RS04655	COG0149	triose-phosphate isomerase activity
D9T12_RS04670	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D9T12_RS04675	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D9T12_RS04680	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D9T12_RS04685	COG0649	NAD binding
D9T12_RS04700	COG1034	ATP synthesis coupled electron transport
D9T12_RS04705	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D9T12_RS04710	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D9T12_RS04720	COG0713	ATP synthesis coupled electron transport
D9T12_RS04735	COG1007	ATP synthesis coupled electron transport
D9T12_RS04745	COG0210	DNA helicase
D9T12_RS04745	COG0210	DNA helicase
D9T12_RS04755	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D9T12_RS04785	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D9T12_RS04790	COG4660	Part of a membrane complex involved in electron transport
D9T12_RS04795	COG4659	FMN binding
D9T12_RS04800	COG4658	electron transport chain
D9T12_RS04805	COG4656	Part of a membrane complex involved in electron transport
D9T12_RS04810	COG2878	Part of a membrane complex involved in electron transport
D9T12_RS04815	COG4657	Part of a membrane complex involved in electron transport
D9T12_RS04820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D9T12_RS04820	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D9T12_RS04830	COG0330	HflC and HflK could
D9T12_RS04835	COG0489	protein tyrosine kinase activity
D9T12_RS04840	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D9T12_RS04845	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D9T12_RS04850	COG1923	regulation of RNA biosynthetic process
D9T12_RS04855	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D9T12_RS04860	COG0330	HflC and HflK could
D9T12_RS04865	COG0330	HflC and HflK could
D9T12_RS04875	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D9T12_RS04880	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D9T12_RS04890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D9T12_RS04910	COG2915	High frequency lysogenization protein hflD homolog
D9T12_RS04915	COG0482	sulfurtransferase activity
D9T12_RS04920	COG1187	pseudouridine synthase activity
D9T12_RS04935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D9T12_RS04940	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D9T12_RS05015	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D9T12_RS05025	COG0004	ammonium transporteR
D9T12_RS05030	COG1067	ATP-dependent peptidase activity
D9T12_RS05040	COG0658	competence protein
D9T12_RS05040	COG2333	competence protein COMEC
D9T12_RS05045	COG1663	tetraacyldisaccharide 4'-kinase activity
D9T12_RS05050	COG2835	tetraacyldisaccharide 4'-kinase activity
D9T12_RS05055	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D9T12_RS05065	COG2814	Major facilitator Superfamily
D9T12_RS05075	COG3264	Mechanosensitive ion channel
D9T12_RS05075	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D9T12_RS05080	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D9T12_RS05085	COG3002	Belongs to the UPF0753 family
D9T12_RS05090	COG0840	transmembrane signaling receptor activity
D9T12_RS05090	COG0840	transmembrane signaling receptor activity
D9T12_RS05100	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D9T12_RS05110	COG1042	CoA-binding domain protein
D9T12_RS05110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9T12_RS05110	COG0045	succinate-CoA ligase (ADP-forming) activity
D9T12_RS05115	COG0123	including yeast histone deacetylase and acetoin utilization protein
D9T12_RS05120	COG3706	GGDEF domain
D9T12_RS05125	COG3676	manually curated
D9T12_RS05135	COG0205	6-phosphofructokinase activity
D9T12_RS05140	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D9T12_RS05145	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D9T12_RS05150	COG0840	transmembrane signaling receptor activity
D9T12_RS05160	COG0745	RESPONSE REGULATOR receiver
D9T12_RS05165	COG2205	protein histidine kinase activity
D9T12_RS05170	COG3101	peptidyl-lysine hydroxylation
D9T12_RS05175	COG1643	Atp-dependent helicase
D9T12_RS05195	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D9T12_RS05200	COG0352	thiamine-phosphate diphosphorylase activity
D9T12_RS05210	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D9T12_RS05225	COG1999	signal sequence binding
D9T12_RS05240	COG0189	ligase activity
D9T12_RS05245	COG0717	Belongs to the dCTP deaminase family
D9T12_RS05255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D9T12_RS05260	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D9T12_RS05270	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D9T12_RS05275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9T12_RS05290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9T12_RS05305	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D9T12_RS05325	COG5002	protein histidine kinase activity
D9T12_RS05325	COG2205	protein histidine kinase activity
D9T12_RS05325	COG0784	Response regulator, receiver
D9T12_RS05360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9T12_RS05365	COG1120	ATPase activity
D9T12_RS05380	COG3706	GGDEF domain
D9T12_RS05385	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D9T12_RS05400	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D9T12_RS05405	COG0735	belongs to the Fur family
D9T12_RS05410	COG0497	DNA recombination
D9T12_RS05415	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D9T12_RS05420	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D9T12_RS05425	COG0443	Heat shock 70 kDa protein
D9T12_RS05430	COG0484	heat shock protein binding
D9T12_RS05435	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D9T12_RS05440	COG0791	NLP P60 protein
D9T12_RS05445	COG0505	Belongs to the CarA family
D9T12_RS05455	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D9T12_RS05465	COG2833	Protein of unknown function (DUF455)
D9T12_RS05470	COG1940	carbohydrate kinase activity
D9T12_RS05480	COG0300	oxidoreductase activity
D9T12_RS05485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9T12_RS05495	COG5002	protein histidine kinase activity
D9T12_RS05500	COG2197	response regulator
D9T12_RS05515	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D9T12_RS05530	COG0835	chemotaxis
D9T12_RS05545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D9T12_RS05550	COG0481	GTPase activity
D9T12_RS05560	COG0571	ribonuclease III activity
D9T12_RS05565	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D9T12_RS05575	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D9T12_RS05580	COG0736	holo-[acyl-carrier-protein] synthase activity
D9T12_RS05610	COG0217	transcriptional regulatory protein
D9T12_RS05615	COG2824	Alkylphosphonate utilization operon protein PhnA
D9T12_RS05625	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D9T12_RS05630	COG0542	response to heat
D9T12_RS05635	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D9T12_RS05640	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D9T12_RS05645	COG0587	DNA-directed DNA polymerase activity
D9T12_RS05650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D9T12_RS05660	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D9T12_RS05675	COG0779	Required for maturation of 30S ribosomal subunits
D9T12_RS05680	COG0195	Participates in both transcription termination and antitermination
D9T12_RS05680	COG2251	uridine kinase activity
D9T12_RS05685	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D9T12_RS05690	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D9T12_RS05695	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D9T12_RS05715	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D9T12_RS05725	COG1185	polyribonucleotide nucleotidyltransferase activity
D9T12_RS05740	COG3118	belongs to the thioredoxin family
D9T12_RS05745	COG2850	peptidyl-arginine hydroxylation
D9T12_RS05755	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D9T12_RS05775	COG0322	excinuclease ABC activity
D9T12_RS05820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D9T12_RS05830	COG0826	peptidase U32
D9T12_RS05835	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D9T12_RS05860	COG2954	triphosphatase activity
D9T12_RS05865	COG1538	Outer membrane efflux protein
D9T12_RS05875	COG1376	ErfK ybiS ycfS ynhG family protein
D9T12_RS05880	COG0601	transmembrane transport
D9T12_RS05885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9T12_RS05895	COG1472	Belongs to the glycosyl hydrolase 3 family
D9T12_RS05900	COG0668	transmembrane transport
D9T12_RS05905	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D9T12_RS05910	COG0733	neurotransmitter:sodium symporter activity
D9T12_RS05920	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D9T12_RS05935	COG2022	thiamine diphosphate biosynthetic process
D9T12_RS05955	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D9T12_RS05965	COG0446	pyridine nucleotide-disulphide oxidoreductase
D9T12_RS05975	COG4591	ABC-type transport system involved in lipoprotein release permease component
D9T12_RS05980	COG1136	(ABC) transporter
D9T12_RS05985	COG0488	(ABC) transporter
D9T12_RS05990	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D9T12_RS05995	COG0544	peptidyl-prolyl cis-trans isomerase activity
D9T12_RS06000	COG0740	serine-type endopeptidase activity
D9T12_RS06005	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D9T12_RS06010	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D9T12_RS06055	COG0747	negative chemotaxis
D9T12_RS06060	COG0601	transmembrane transport
D9T12_RS06070	COG4172	Belongs to the ABC transporter superfamily
D9T12_RS06085	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D9T12_RS06095	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D9T12_RS06100	COG0077	Prephenate dehydratase
D9T12_RS06100	COG1605	Chorismate mutase
D9T12_RS06105	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D9T12_RS06110	COG0287	Prephenate dehydrogenase
D9T12_RS06115	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D9T12_RS06120	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D9T12_RS06130	COG0776	regulation of translation
D9T12_RS06140	COG0284	orotidine-5'-phosphate decarboxylase activity
D9T12_RS06145	COG0360	Binds together with S18 to 16S ribosomal RNA
D9T12_RS06150	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D9T12_RS06160	COG0359	binds to the 23S rRNA
D9T12_RS06165	COG0305	Participates in initiation and elongation during chromosome replication
D9T12_RS06170	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D9T12_RS06175	COG0494	nUDIX hydrolase
D9T12_RS06185	COG0534	Mate efflux family protein
D9T12_RS06190	COG3012	SEC-C Motif Domain Protein
D9T12_RS06210	COG0745	RESPONSE REGULATOR receiver
D9T12_RS06220	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D9T12_RS06235	COG1393	Belongs to the ArsC family
D9T12_RS06245	COG1570	exodeoxyribonuclease VII activity
D9T12_RS06250	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D9T12_RS06255	COG3706	GGDEF domain
D9T12_RS06260	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D9T12_RS06295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D9T12_RS06310	COG2900	Belongs to the SlyX family
D9T12_RS06325	COG1994	Peptidase M50
D9T12_RS06330	COG0009	L-threonylcarbamoyladenylate synthase
D9T12_RS06340	COG0613	PHP domain protein
D9T12_RS06345	COG2917	probably involved in intracellular septation
D9T12_RS06350	COG2350	Protein conserved in bacteria
D9T12_RS06355	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D9T12_RS06360	COG0252	asparaginase activity
D9T12_RS06370	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D9T12_RS06380	COG1070	Carbohydrate kinase
D9T12_RS06390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D9T12_RS06425	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D9T12_RS06440	COG0436	Aminotransferase
D9T12_RS06455	COG1238	metal cluster binding
D9T12_RS06460	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D9T12_RS06465	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D9T12_RS06470	COG1193	negative regulation of DNA recombination
D9T12_RS06475	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D9T12_RS06480	COG0148	phosphopyruvate hydratase activity
D9T12_RS06485	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D9T12_RS06490	COG0504	CTP synthase activity
D9T12_RS06495	COG0037	tRNA processing
D9T12_RS06500	COG0825	malonyl-CoA metabolic process
D9T12_RS06510	COG1944	ATP diphosphatase activity
D9T12_RS06535	COG1199	ATP-dependent helicase activity
D9T12_RS06540	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D9T12_RS06545	COG1981	membrane
D9T12_RS06550	COG1047	Peptidyl-prolyl cis-trans
D9T12_RS06560	COG2983	Belongs to the UPF0260 family
D9T12_RS06565	COG3706	GGDEF domain
D9T12_RS06580	COG0835	chemotaxis
D9T12_RS06580	COG0784	Response regulator, receiver
D9T12_RS06585	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D9T12_RS06590	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D9T12_RS06595	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D9T12_RS06600	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D9T12_RS06605	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D9T12_RS06615	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D9T12_RS06625	COG0575	Belongs to the CDS family
D9T12_RS06630	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D9T12_RS06635	COG0233	cytoplasmic translational termination
D9T12_RS06640	COG0528	UMP kinase activity
D9T12_RS06645	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D9T12_RS06650	COG0052	Belongs to the universal ribosomal protein uS2 family
D9T12_RS06655	COG0024	Methionine aminopeptidase
D9T12_RS06660	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D9T12_RS06675	COG2171	N-acyltransferase activity
D9T12_RS06680	COG1393	Belongs to the ArsC family
D9T12_RS06685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9T12_RS06710	COG2205	protein histidine kinase activity
D9T12_RS06710	COG0784	Response regulator, receiver
D9T12_RS06720	COG0501	Belongs to the peptidase M48B family
D9T12_RS06725	COG1704	LemA family
D9T12_RS06730	COG3706	GGDEF domain
D9T12_RS06735	COG0545	Peptidyl-prolyl cis-trans isomerase
D9T12_RS06740	COG2133	pyrroloquinoline quinone binding
D9T12_RS06750	COG1192	Involved in chromosome partitioning
D9T12_RS06760	COG0778	Nitroreductase
D9T12_RS06765	COG1671	Belongs to the UPF0178 family
D9T12_RS06770	COG0488	(ABC) transporter
D9T12_RS06775	COG0513	Belongs to the DEAD box helicase family
D9T12_RS06800	COG2199	diguanylate cyclase activity
D9T12_RS06835	COG0513	Belongs to the DEAD box helicase family
D9T12_RS06860	COG3530	Putative quorum-sensing-regulated virulence factor
D9T12_RS06870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D9T12_RS06875	COG0508	dehydrogenase complex catalyzes the overall conversion of
D9T12_RS06880	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D9T12_RS06885	COG1051	belongs to the nudix hydrolase family
D9T12_RS06895	COG1012	belongs to the aldehyde dehydrogenase family
D9T12_RS06900	COG0006	proline dipeptidase activity
D9T12_RS06910	COG1473	amidohydrolase
D9T12_RS06940	COG1496	oxidoreductase activity
D9T12_RS06945	COG0564	pseudouridine synthase activity
D9T12_RS06950	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D9T12_RS06955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D9T12_RS06955	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D9T12_RS06965	COG0045	succinate-CoA ligase (ADP-forming) activity
D9T12_RS07005	COG1643	Atp-dependent helicase
D9T12_RS07015	COG1047	Peptidyl-prolyl cis-trans
D9T12_RS07020	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D9T12_RS07025	COG0328	RNA-DNA hybrid ribonuclease activity
D9T12_RS07035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D9T12_RS07040	COG1388	LysM domain
D9T12_RS07040	COG0741	lytic transglycosylase activity
D9T12_RS07045	COG0739	heme binding
D9T12_RS07045	COG0741	lytic transglycosylase activity
D9T12_RS07045	COG1196	nuclear chromosome segregation
D9T12_RS07050	COG0215	cysteine-tRNA ligase activity
D9T12_RS07065	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D9T12_RS07070	COG1301	dicarboxylic acid transport
D9T12_RS07080	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D9T12_RS07175	COG0137	argininosuccinate synthase activity
D9T12_RS07180	COG0688	phosphatidylethanolamine metabolic process
D9T12_RS07190	COG1238	metal cluster binding
D9T12_RS07200	COG2204	response regulator
D9T12_RS07205	COG3852	Histidine kinase
D9T12_RS07230	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D9T12_RS07240	COG2885	chlorophyll binding
D9T12_RS07245	COG0823	Involved in the tonB-independent uptake of proteins
D9T12_RS07265	COG2255	four-way junction helicase activity
D9T12_RS07270	COG0632	four-way junction helicase activity
D9T12_RS07275	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D9T12_RS07280	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D9T12_RS07285	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D9T12_RS07300	COG0142	geranyltranstransferase activity
D9T12_RS07305	COG0720	synthase
D9T12_RS07310	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D9T12_RS07325	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D9T12_RS07330	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D9T12_RS07335	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D9T12_RS07340	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D9T12_RS07355	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D9T12_RS07355	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D9T12_RS07360	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D9T12_RS07365	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D9T12_RS07370	COG0488	(ABC) transporter
D9T12_RS07415	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D9T12_RS07415	COG0047	phosphoribosylformylglycinamidine synthase activity
D9T12_RS07425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D9T12_RS07430	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D9T12_RS07435	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D9T12_RS07445	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D9T12_RS07450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D9T12_RS07455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D9T12_RS07460	COG0006	proline dipeptidase activity
D9T12_RS07465	COG3079	Belongs to the UPF0149 family
D9T12_RS07475	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D9T12_RS07480	COG0860	N-Acetylmuramoyl-L-alanine amidase
D9T12_RS07485	COG0802	atpase or kinase
D9T12_RS07490	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D9T12_RS07495	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D9T12_RS07505	COG2982	Protein involved in outer membrane biogenesis
D9T12_RS07515	COG0442	prolyl-tRNA aminoacylation
D9T12_RS07520	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D9T12_RS07530	COG4206	TonB-dependent receptor
D9T12_RS07535	COG1492	cobalamin metabolic process
D9T12_RS07545	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D9T12_RS07550	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D9T12_RS07555	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D9T12_RS07560	COG0837	glucose binding
D9T12_RS07580	COG2207	Transcriptional regulator
D9T12_RS07600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9T12_RS07610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D9T12_RS07630	COG0701	Predicted permease
D9T12_RS07640	COG3040	lipid binding
D9T12_RS07645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D9T12_RS07660	COG3437	response regulator, receiver
D9T12_RS07700	COG1132	(ABC) transporter
D9T12_RS07705	COG0084	hydrolase, TatD family'
D9T12_RS07710	COG0470	DNA polymerase III
D9T12_RS07715	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D9T12_RS07720	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D9T12_RS07725	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D9T12_RS07730	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D9T12_RS07735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D9T12_RS07740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D9T12_RS07745	COG1028	Short-chain dehydrogenase reductase Sdr
D9T12_RS07750	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D9T12_RS07755	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D9T12_RS07760	COG0416	fatty acid biosynthetic process
D9T12_RS07765	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D9T12_RS07770	COG1399	metal-binding, possibly nucleic acid-binding protein
D9T12_RS07775	COG0424	maF-like protein
D9T12_RS07785	COG0564	pseudouridine synthase activity
D9T12_RS07790	COG1530	ribonuclease E activity
D9T12_RS07800	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D9T12_RS07830	COG0582	viral genome integration into host DNA
D9T12_RS07885	COG4453	Protein conserved in bacteria
D9T12_RS07935	COG1192	Involved in chromosome partitioning
D9T12_RS07970	COG1487	ribonuclease activity
D9T12_RS07990	COG1106	Psort location Cytoplasmic, score
D9T12_RS08050	COG5642	Protein of unknown function (DUF2384)
D9T12_RS08195	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D9T12_RS08210	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D9T12_RS08265	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D9T12_RS08280	COG1396	sequence-specific DNA binding
D9T12_RS08335	COG0582	viral genome integration into host DNA
D9T12_RS08345	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D9T12_RS08350	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D9T12_RS08355	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D9T12_RS08360	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D9T12_RS08365	COG1674	ftsk spoiiie
D9T12_RS08365	COG0531	amino acid
D9T12_RS08370	COG0492	ferredoxin-NADP+ reductase activity
D9T12_RS08375	COG0545	Peptidyl-prolyl cis-trans isomerase
D9T12_RS08395	COG2201	protein-glutamate methylesterase activity
D9T12_RS08410	COG0835	chemotaxis
D9T12_RS08415	COG0745	RESPONSE REGULATOR receiver
D9T12_RS08430	COG0835	chemotaxis
D9T12_RS08435	COG2198	Histidine kinase
D9T12_RS08435	COG0784	Response regulator, receiver
D9T12_RS08435	COG0643	Histidine kinase
D9T12_RS08440	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
D9T12_RS08470	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D9T12_RS08475	COG1684	flagellar biosynthetic protein fliR
D9T12_RS08480	COG1987	bacterial-type flagellum assembly
D9T12_RS08510	COG1360	Flagellar Motor Protein
D9T12_RS08515	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D9T12_RS08545	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D9T12_RS08555	COG1677	Flagellar hook-basal body complex protein FliE
D9T12_RS08580	COG1516	flagellar protein fliS
D9T12_RS08600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D9T12_RS08605	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D9T12_RS08610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D9T12_RS08620	COG2089	acid synthase
D9T12_RS08635	COG1083	cytidylyl-transferase
D9T12_RS08645	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D9T12_RS08650	COG1086	Polysaccharide biosynthesis protein
D9T12_RS08660	COG0741	lytic transglycosylase activity
D9T12_RS08670	COG4786	Flagellar basal body rod
D9T12_RS08670	COG1256	bacterial-type flagellum assembly
D9T12_RS08680	COG1706	bacterial-type flagellum-dependent cell motility
D9T12_RS08710	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D9T12_RS08715	COG4786	Flagellar basal body rod
D9T12_RS08720	COG4786	Flagellar basal body rod
D9T12_RS08725	COG1749	Flagellar hook protein flgE
D9T12_RS08740	COG1815	bacterial-type flagellum-dependent cell motility
D9T12_RS08750	COG0784	Response regulator, receiver
D9T12_RS08750	COG0835	chemotaxis
D9T12_RS08760	COG2747	anti-sigma28 factor FlgM
D9T12_RS08775	COG5001	Diguanylate cyclase
D9T12_RS08775	COG3300	MHYT domain
D9T12_RS08805	COG0308	aminopeptidase N
D9T12_RS08815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9T12_RS08820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D9T12_RS08825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D9T12_RS08830	COG0557	exoribonuclease II activity
D9T12_RS08835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D9T12_RS08840	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
D9T12_RS08845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D9T12_RS08845	COG0301	tRNA thio-modification
D9T12_RS08850	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D9T12_RS08855	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D9T12_RS08860	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D9T12_RS08865	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D9T12_RS08870	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D9T12_RS08880	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D9T12_RS08885	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D9T12_RS08890	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D9T12_RS08895	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D9T12_RS08900	COG0617	tRNA 3'-terminal CCA addition
D9T12_RS08940	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D9T12_RS08945	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D9T12_RS08955	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D9T12_RS08960	COG1546	Belongs to the CinA family
D9T12_RS09040	COG4974	Belongs to the 'phage' integrase family
D9T12_RS09055	COG2003	Belongs to the UPF0758 family
D9T12_RS09065	COG1396	sequence-specific DNA binding
D9T12_RS09110	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D9T12_RS09135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D9T12_RS09145	COG0784	Response regulator, receiver
D9T12_RS09145	COG2205	protein histidine kinase activity
D9T12_RS09150	COG3384	dioxygenase
D9T12_RS09185	COG2945	thiolester hydrolase activity
D9T12_RS09190	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D9T12_RS09195	COG3439	Domain of unknown function DUF302
D9T12_RS09200	COG0446	pyridine nucleotide-disulphide oxidoreductase
D9T12_RS09215	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D9T12_RS09220	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D9T12_RS09240	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D9T12_RS09250	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D9T12_RS09260	COG0795	lipopolysaccharide-transporting ATPase activity
D9T12_RS09265	COG0795	lipopolysaccharide-transporting ATPase activity
D9T12_RS09270	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D9T12_RS09300	COG0556	nucleotide-excision repair
D9T12_RS09305	COG0436	Aminotransferase
D9T12_RS09310	COG1793	dna ligase
D9T12_RS09320	COG0542	response to heat
D9T12_RS09325	COG0326	Molecular chaperone. Has ATPase activity
D9T12_RS09335	COG0643	Histidine kinase
D9T12_RS09335	COG2198	Histidine kinase
D9T12_RS09340	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D9T12_RS09360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D9T12_RS09360	COG0519	Catalyzes the synthesis of GMP from XMP
D9T12_RS09365	COG0517	IMP dehydrogenase activity
D9T12_RS09365	COG0516	GMP reductase activity
D9T12_RS09385	COG0560	Phosphoserine phosphatase
D9T12_RS09390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D9T12_RS09395	COG0811	peptide transport
D9T12_RS09400	COG0848	biopolymer transport protein
D9T12_RS09405	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
D9T12_RS09410	COG2166	iron-sulfur cluster assembly
D9T12_RS09420	COG0501	Belongs to the peptidase M48B family
D9T12_RS09435	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D9T12_RS09440	COG0154	amidase activity
D9T12_RS09445	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D9T12_RS09450	COG1077	Cell shape determining protein MreB Mrl
D9T12_RS09455	COG1792	Involved in formation and maintenance of cell shape
D9T12_RS09465	COG0768	penicillin binding
D9T12_RS09470	COG0772	Belongs to the SEDS family
D9T12_RS09475	COG1686	Belongs to the peptidase S11 family
D9T12_RS09480	COG2921	Belongs to the UPF0250 family
D9T12_RS09485	COG0321	lipoyl(octanoyl) transferase activity
D9T12_RS09490	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D9T12_RS09515	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D9T12_RS09540	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D9T12_RS09550	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D9T12_RS09555	COG1509	lysine 2,3-aminomutase activity
D9T12_RS09595	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D9T12_RS09605	COG1450	Type ii and iii secretion system protein
D9T12_RS09615	COG3409	Peptidoglycan-binding domain 1 protein
D9T12_RS09615	COG3267	Type II secretory pathway component ExeA
D9T12_RS09655	COG0424	maF-like protein
D9T12_RS09680	COG3307	-O-antigen
D9T12_RS09690	COG0438	transferase activity, transferring glycosyl groups
D9T12_RS09700	COG1132	(ABC) transporter
D9T12_RS09705	COG1560	Kdo2-lipid A biosynthetic process
D9T12_RS09710	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D9T12_RS09710	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D9T12_RS09715	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D9T12_RS09730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D9T12_RS09735	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D9T12_RS09745	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D9T12_RS09750	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D9T12_RS09755	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D9T12_RS09775	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D9T12_RS09785	COG3585	molybdate ion transport
D9T12_RS09800	COG4149	molybdate abc transporter
D9T12_RS09815	COG2204	response regulator
D9T12_RS09825	COG2010	Cytochrome c
D9T12_RS09830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D9T12_RS09845	COG0116	Belongs to the methyltransferase superfamily
D9T12_RS09845	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D9T12_RS09850	COG2951	lytic endotransglycosylase activity
D9T12_RS09860	COG2199	diguanylate cyclase activity
D9T12_RS09860	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D9T12_RS09865	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D9T12_RS09870	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D9T12_RS09875	COG0196	riboflavin kinase activity
D9T12_RS09890	COG0268	Binds directly to 16S ribosomal RNA
D9T12_RS09905	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D9T12_RS09910	COG0799	negative regulation of ribosome biogenesis
D9T12_RS09915	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D9T12_RS09920	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D9T12_RS09935	COG0495	leucyl-tRNA aminoacylation
D9T12_RS09945	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D9T12_RS09950	COG4535	Mg2 and Co2 transporter CorC
D9T12_RS09955	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D9T12_RS09960	COG1702	phosphate starvation-inducible protein PhoH
D9T12_RS09965	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D9T12_RS10025	COG0058	SHG alpha-glucan phosphorylase activity
D9T12_RS10030	COG0297	glycogen (starch) synthase activity
D9T12_RS10035	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D9T12_RS10050	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D9T12_RS10055	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D9T12_RS10055	COG0517	IMP dehydrogenase activity
D9T12_RS10060	COG1519	Transferase
D9T12_RS10070	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D9T12_RS10075	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D9T12_RS10085	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D9T12_RS10090	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D9T12_RS10100	COG2226	methyltransferase
D9T12_RS10110	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D9T12_RS10175	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D9T12_RS10210	COG0012	GTP binding
D9T12_RS10215	COG0193	aminoacyl-tRNA hydrolase activity
D9T12_RS10220	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D9T12_RS10225	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D9T12_RS10240	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D9T12_RS10245	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D9T12_RS10250	COG2890	protein-(glutamine-N5) methyltransferase activity
D9T12_RS10255	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D9T12_RS10260	COG1360	Flagellar Motor Protein
D9T12_RS10265	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D9T12_RS10280	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D9T12_RS10285	COG5001	Diguanylate cyclase
D9T12_RS10285	COG4251	negative regulation of phosphorylation
D9T12_RS10285	COG3706	GGDEF domain
D9T12_RS10285	COG2203	Gaf domain
D9T12_RS10290	COG5001	Diguanylate cyclase
D9T12_RS10290	COG3300	MHYT domain
D9T12_RS10315	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D9T12_RS10340	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D9T12_RS10345	COG0751	glycine-tRNA ligase activity
D9T12_RS10360	COG0739	heme binding
D9T12_RS10365	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D9T12_RS10375	COG0316	Belongs to the HesB IscA family
D9T12_RS10380	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D9T12_RS10385	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D9T12_RS10390	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
D9T12_RS10420	COG2885	chlorophyll binding
D9T12_RS10435	COG2197	response regulator
D9T12_RS10445	COG3300	MHYT domain
D9T12_RS10445	COG5001	Diguanylate cyclase
D9T12_RS10460	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D9T12_RS10475	COG1090	epimerase
D9T12_RS10480	COG0579	oxidoreductase
D9T12_RS10485	COG0523	cobalamin synthesis protein
D9T12_RS10490	COG1469	GTP cyclohydrolase I activity
D9T12_RS10500	COG0628	permease
D9T12_RS10505	COG1611	Belongs to the LOG family
D9T12_RS10510	COG0513	Belongs to the DEAD box helicase family
D9T12_RS10520	COG1012	belongs to the aldehyde dehydrogenase family
D9T12_RS10525	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D9T12_RS10540	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D9T12_RS10565	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
D9T12_RS10570	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D9T12_RS10590	COG0668	transmembrane transport
D9T12_RS10595	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D9T12_RS10600	COG1666	GTP binding
D9T12_RS10605	COG0436	Aminotransferase
D9T12_RS10610	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D9T12_RS10625	COG1394	ATPase activity, coupled to movement of substances
D9T12_RS10630	COG1269	ATP hydrolysis coupled proton transport
D9T12_RS10650	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
D9T12_RS10655	COG0756	dUTP diphosphatase activity
D9T12_RS10660	COG2203	Gaf domain
D9T12_RS10660	COG4251	negative regulation of phosphorylation
D9T12_RS10660	COG5001	Diguanylate cyclase
D9T12_RS10660	COG3706	GGDEF domain
D9T12_RS10715	COG0033	Phosphoglucomutase
D9T12_RS10720	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D9T12_RS10745	COG0438	transferase activity, transferring glycosyl groups
D9T12_RS10750	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D9T12_RS10760	COG0446	pyridine nucleotide-disulphide oxidoreductase
D9T12_RS10775	COG2003	Belongs to the UPF0758 family
D9T12_RS10785	COG2010	Cytochrome c
D9T12_RS10790	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D9T12_RS10795	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D9T12_RS10815	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D9T12_RS10825	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D9T12_RS10845	COG1473	amidohydrolase
D9T12_RS10855	COG2200	EAL domain
D9T12_RS10855	COG2199	diguanylate cyclase activity
D9T12_RS10865	COG0450	alkyl hydroperoxide reductase
D9T12_RS10870	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D9T12_RS10875	COG0742	ribosomal rna small subunit methyltransferase
D9T12_RS10880	COG0784	Response regulator, receiver
D9T12_RS10880	COG2205	protein histidine kinase activity
D9T12_RS10890	COG0612	Peptidase, M16
D9T12_RS10895	COG0612	Peptidase, M16
D9T12_RS10900	COG0552	protein localization to endoplasmic reticulum
D9T12_RS10920	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D9T12_RS10935	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D9T12_RS10975	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D9T12_RS10980	COG0167	dihydroorotate dehydrogenase activity
D9T12_RS10985	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D9T12_RS10990	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D9T12_RS10995	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D9T12_RS11010	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D9T12_RS11015	COG0067	glutamate synthase
D9T12_RS11015	COG0069	glutamate synthase activity
D9T12_RS11015	COG0070	glutamate synthase
D9T12_RS11020	COG0493	'glutamate synthase
D9T12_RS11035	COG2814	Major facilitator Superfamily
D9T12_RS11055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D9T12_RS11060	COG3706	GGDEF domain
D9T12_RS11070	COG3706	GGDEF domain
D9T12_RS11075	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D9T12_RS11080	COG0840	transmembrane signaling receptor activity
D9T12_RS11090	COG4771	TonB-dependent receptor
D9T12_RS11100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9T12_RS11105	COG0390	transport system, permease component
D9T12_RS11125	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D9T12_RS11130	COG0254	rRNA binding
D9T12_RS11140	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D9T12_RS11145	COG5001	Diguanylate cyclase
D9T12_RS11145	COG3447	MASE1 domain protein
D9T12_RS11145	COG5002	protein histidine kinase activity
D9T12_RS11165	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D9T12_RS11170	COG1854	S-ribosylhomocysteine lyase activity
D9T12_RS11190	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D9T12_RS11190	COG0678	peroxiredoxin activity
D9T12_RS11200	COG2081	HI0933 family
D9T12_RS11210	COG0351	phosphomethylpyrimidine kinase
D9T12_RS11215	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D9T12_RS11215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9T12_RS11220	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D9T12_RS11225	COG1444	tRNA N-acetyltransferase activity
D9T12_RS11235	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D9T12_RS11245	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D9T12_RS11255	COG4771	TonB-dependent receptor
D9T12_RS11260	COG5002	protein histidine kinase activity
D9T12_RS11265	COG0745	RESPONSE REGULATOR receiver
D9T12_RS11280	COG2827	Endonuclease containing a URI domain
D9T12_RS11285	COG3706	GGDEF domain
D9T12_RS11290	COG0315	cyclic pyranopterin monophosphate synthase activity
D9T12_RS11295	COG0583	DNA-binding transcription factor activity
D9T12_RS11315	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D9T12_RS11320	COG2207	Transcriptional regulator
D9T12_RS11325	COG4771	TonB-dependent receptor
D9T12_RS11345	COG1132	(ABC) transporter
D9T12_RS11350	COG2226	methyltransferase
D9T12_RS11365	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D9T12_RS11375	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D9T12_RS11380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9T12_RS11385	COG4558	Periplasmic binding protein
D9T12_RS11390	COG3720	iron ion transport
D9T12_RS11400	COG4206	TonB-dependent receptor
D9T12_RS11405	COG0748	coenzyme F420 binding
D9T12_RS11410	COG0840	transmembrane signaling receptor activity
D9T12_RS11415	COG4774	siderophore transport
D9T12_RS11425	COG0523	cobalamin synthesis protein
D9T12_RS11435	COG0735	belongs to the Fur family
D9T12_RS11445	COG0450	alkyl hydroperoxide reductase
D9T12_RS11450	COG1528	Iron-storage protein
D9T12_RS11455	COG4774	siderophore transport
D9T12_RS11465	COG3128	pkhd-type hydroxylase
D9T12_RS11475	COG4772	TonB-dependent receptor
D9T12_RS11480	COG3706	GGDEF domain
D9T12_RS11490	COG0314	molybdopterin synthase activity
D9T12_RS11495	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D9T12_RS11500	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D9T12_RS11535	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D9T12_RS11545	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D9T12_RS11570	COG2391	methyltransferase activity
D9T12_RS11580	COG1217	gtp-binding protein TYPA
D9T12_RS11585	COG4771	TonB-dependent receptor
D9T12_RS11590	COG1429	ligase activity, forming nitrogen-metal bonds
D9T12_RS11610	COG1490	D-aminoacyl-tRNA deacylase activity
D9T12_RS11615	COG3300	MHYT domain
D9T12_RS11615	COG5001	Diguanylate cyclase
D9T12_RS11650	COG0840	transmembrane signaling receptor activity
D9T12_RS11660	COG2217	Heavy metal translocating P-type atpase
D9T12_RS11670	COG0348	domain, Protein
D9T12_RS11690	COG3278	Belongs to the heme-copper respiratory oxidase family
D9T12_RS11695	COG0131	Imidazoleglycerol-phosphate dehydratase
D9T12_RS11700	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D9T12_RS11705	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D9T12_RS11710	COG0107	imidazoleglycerol-phosphate synthase activity
D9T12_RS11715	COG0140	phosphoribosyl-ATP diphosphatase activity
D9T12_RS11720	COG0537	adenosine 5'-monophosphoramidase activity
D9T12_RS11725	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D9T12_RS11730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D9T12_RS11740	COG1331	Highly conserved protein containing a thioredoxin domain
D9T12_RS11755	COG1230	cation diffusion facilitator family transporter
D9T12_RS11760	COG1040	competence protein
D9T12_RS11765	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D9T12_RS11770	COG0156	8-amino-7-oxononanoate synthase activity
D9T12_RS11775	COG2308	Evidence 4 Homologs of previously reported genes of
D9T12_RS11815	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
D9T12_RS11845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D9T12_RS11860	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D9T12_RS11865	COG1074	ATP-dependent DNA helicase activity
D9T12_RS11870	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D9T12_RS11875	COG1116	anion transmembrane transporter activity
D9T12_RS11880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D9T12_RS11885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D9T12_RS11890	COG3604	Transcriptional regulator
D9T12_RS11945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9T12_RS11960	COG0840	transmembrane signaling receptor activity
D9T12_RS11975	COG3437	response regulator, receiver
D9T12_RS11990	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D9T12_RS12005	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D9T12_RS12010	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D9T12_RS12025	COG0676	glucose-6-phosphate 1-epimerase activity
D9T12_RS12030	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D9T12_RS12035	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D9T12_RS12040	COG0194	GDP metabolic process
D9T12_RS12045	COG1758	RNA polymerase activity
D9T12_RS12050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D9T12_RS12060	COG0561	phosphatase activity
D9T12_RS12065	COG0748	coenzyme F420 binding
D9T12_RS12070	COG0004	ammonium transporteR
D9T12_RS12075	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D9T12_RS12080	COG3850	Histidine kinase
D9T12_RS12085	COG2197	response regulator
D9T12_RS12105	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D9T12_RS12120	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D9T12_RS12125	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D9T12_RS12135	COG1595	DNA-templated transcription, initiation
D9T12_RS12145	COG3161	chorismate lyase activity
D9T12_RS12170	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D9T12_RS12190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9T12_RS12195	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D9T12_RS12200	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D9T12_RS12210	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D9T12_RS12215	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D9T12_RS12220	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D9T12_RS12225	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D9T12_RS12230	COG0356	it plays a direct role in the translocation of protons across the membrane
D9T12_RS12250	COG1192	Involved in chromosome partitioning
D9T12_RS12255	COG0357	Ribosomal RNA small subunit methyltransferase G
D9T12_RS12260	COG0445	tRNA wobble uridine modification
D9T12_RS12280	COG4176	ABC-type proline glycine betaine transport system permease component
D9T12_RS12285	COG2113	Glycine betaine
D9T12_RS12295	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D9T12_RS12295	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D9T12_RS12335	COG1739	Uncharacterized protein family UPF0029
D9T12_RS12340	COG0840	transmembrane signaling receptor activity
D9T12_RS12350	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D9T12_RS12360	COG0706	membrane insertase activity
D9T12_RS12365	COG0594	ribonuclease P activity
D9T12_RS12370	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D9T12_RS12380	COG0730	response to heat