locus-tag	class	description
THMIRH_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THMIRH_RS00010	COG0592	DNA-directed DNA polymerase activity
THMIRH_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THMIRH_RS00020	COG0187	DNA topoisomerase II activity
THMIRH_RS00025	COG3954	Phosphoribulokinase
THMIRH_RS00055	COG4783	chaperone-mediated protein folding
THMIRH_RS00060	COG0009	L-threonylcarbamoyladenylate synthase
THMIRH_RS00080	COG0840	transmembrane signaling receptor activity
THMIRH_RS00090	COG0415	Belongs to the DNA photolyase family
THMIRH_RS00100	COG3046	protein related to deoxyribodipyrimidine photolyase
THMIRH_RS00115	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THMIRH_RS00120	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
THMIRH_RS00125	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THMIRH_RS00125	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THMIRH_RS00165	COG0778	Nitroreductase
THMIRH_RS00170	COG0432	Pfam Uncharacterised protein family UPF0047
THMIRH_RS00175	COG0840	transmembrane signaling receptor activity
THMIRH_RS00180	COG0840	transmembrane signaling receptor activity
THMIRH_RS00210	COG1283	sodium-dependent phosphate transmembrane transporter activity
THMIRH_RS00215	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
THMIRH_RS00220	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
THMIRH_RS00225	COG2198	Histidine kinase
THMIRH_RS00225	COG0784	Response regulator, receiver
THMIRH_RS00225	COG5002	protein histidine kinase activity
THMIRH_RS00245	COG2853	Lipoprotein
THMIRH_RS00280	COG1858	cytochrome C peroxidase
THMIRH_RS00290	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
THMIRH_RS00295	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
THMIRH_RS00300	COG1333	cytochrome c biogenesis protein
THMIRH_RS00305	COG0218	Necessary for normal cell division and for the maintenance of normal septation
THMIRH_RS00325	COG0514	ATP-dependent DNA helicase (RecQ)
THMIRH_RS00340	COG1252	NADH dehydrogenase
THMIRH_RS00350	COG2837	iron assimilation
THMIRH_RS00365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THMIRH_RS00370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THMIRH_RS00375	COG3706	GGDEF domain
THMIRH_RS00375	COG4251	negative regulation of phosphorylation
THMIRH_RS00375	COG5001	Diguanylate cyclase
THMIRH_RS00375	COG2203	Gaf domain
THMIRH_RS00385	COG0330	HflC and HflK could
THMIRH_RS00395	COG2731	YhcH YjgK YiaL family protein
THMIRH_RS00405	COG0167	dihydroorotate dehydrogenase activity
THMIRH_RS00410	COG2095	MarC family integral membrane protein
THMIRH_RS00435	COG0450	alkyl hydroperoxide reductase
THMIRH_RS00470	COG0714	Associated with various cellular activities
THMIRH_RS00480	COG0784	Response regulator, receiver
THMIRH_RS00480	COG2205	protein histidine kinase activity
THMIRH_RS00490	COG0500	methyltransferase
THMIRH_RS00495	COG2226	methyltransferase
THMIRH_RS00505	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THMIRH_RS00510	COG0714	Associated with various cellular activities
THMIRH_RS00565	COG0515	serine threonine protein kinase
THMIRH_RS00575	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
THMIRH_RS00580	COG3706	GGDEF domain
THMIRH_RS00585	COG0165	Argininosuccinate lyase
THMIRH_RS00595	COG0181	hydroxymethylbilane synthase activity
THMIRH_RS00625	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
THMIRH_RS00630	COG0280	phosphate acetyltransferase
THMIRH_RS00630	COG0857	belongs to the CobB CobQ family
THMIRH_RS00635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THMIRH_RS00650	COG0220	tRNA (guanine-N7-)-methyltransferase activity
THMIRH_RS00655	COG1194	a g-specific adenine glycosylase
THMIRH_RS00660	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
THMIRH_RS00665	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
THMIRH_RS00675	COG0445	tRNA wobble uridine modification
THMIRH_RS00680	COG0357	Ribosomal RNA small subunit methyltransferase G
THMIRH_RS00685	COG1192	Involved in chromosome partitioning
THMIRH_RS00705	COG0356	it plays a direct role in the translocation of protons across the membrane
THMIRH_RS00710	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THMIRH_RS00715	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
THMIRH_RS00720	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THMIRH_RS00725	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
THMIRH_RS00735	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
THMIRH_RS00740	COG0355	proton-transporting ATP synthase activity, rotational mechanism
THMIRH_RS00745	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
THMIRH_RS00750	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
THMIRH_RS00770	COG3161	chorismate lyase activity
THMIRH_RS00775	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THMIRH_RS00780	COG0004	ammonium transporteR
THMIRH_RS00790	COG0803	Belongs to the bacterial solute-binding protein 9 family
THMIRH_RS00795	COG1121	(ABC) transporter
THMIRH_RS00800	COG1321	iron dependent repressor
THMIRH_RS00800	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THMIRH_RS00805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THMIRH_RS00815	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THMIRH_RS00820	COG1758	RNA polymerase activity
THMIRH_RS00830	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
THMIRH_RS00835	COG1454	alcohol dehydrogenase
THMIRH_RS00840	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THMIRH_RS00845	COG0194	GDP metabolic process
THMIRH_RS00850	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
THMIRH_RS00855	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
THMIRH_RS00860	COG0676	glucose-6-phosphate 1-epimerase activity
THMIRH_RS00870	COG3706	GGDEF domain
THMIRH_RS00875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THMIRH_RS00890	COG0840	transmembrane signaling receptor activity
THMIRH_RS00895	COG0784	Response regulator, receiver
THMIRH_RS00895	COG2205	protein histidine kinase activity
THMIRH_RS00895	COG5002	protein histidine kinase activity
THMIRH_RS00910	COG0784	Response regulator, receiver
THMIRH_RS00910	COG2205	protein histidine kinase activity
THMIRH_RS00920	COG0840	transmembrane signaling receptor activity
THMIRH_RS00925	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
THMIRH_RS00950	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
THMIRH_RS00965	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THMIRH_RS00985	COG0840	transmembrane signaling receptor activity
THMIRH_RS01000	COG0156	8-amino-7-oxononanoate synthase activity
THMIRH_RS01005	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THMIRH_RS01010	COG1040	competence protein
THMIRH_RS01020	COG4783	chaperone-mediated protein folding
THMIRH_RS01045	COG2201	protein-glutamate methylesterase activity
THMIRH_RS01065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THMIRH_RS01070	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THMIRH_RS01075	COG0537	adenosine 5'-monophosphoramidase activity
THMIRH_RS01080	COG0140	phosphoribosyl-ATP diphosphatase activity
THMIRH_RS01085	COG0107	imidazoleglycerol-phosphate synthase activity
THMIRH_RS01090	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
THMIRH_RS01095	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
THMIRH_RS01100	COG0131	Imidazoleglycerol-phosphate dehydratase
THMIRH_RS01105	COG3278	Belongs to the heme-copper respiratory oxidase family
THMIRH_RS01130	COG0348	domain, Protein
THMIRH_RS01140	COG2217	Heavy metal translocating P-type atpase
THMIRH_RS01150	COG0513	Belongs to the DEAD box helicase family
THMIRH_RS01155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THMIRH_RS01160	COG1129	ABC transporter
THMIRH_RS01160	COG0842	Transport permease protein
THMIRH_RS01165	COG0842	Transport permease protein
THMIRH_RS01165	COG1129	ABC transporter
THMIRH_RS01170	COG0842	Transport permease protein
THMIRH_RS01175	COG0840	transmembrane signaling receptor activity
THMIRH_RS01175	COG0840	transmembrane signaling receptor activity
THMIRH_RS01185	COG3300	MHYT domain
THMIRH_RS01185	COG5001	Diguanylate cyclase
THMIRH_RS01190	COG2801	Transposase and inactivated derivatives
THMIRH_RS01200	COG0493	'glutamate synthase
THMIRH_RS01205	COG0067	glutamate synthase
THMIRH_RS01205	COG0069	glutamate synthase activity
THMIRH_RS01205	COG0070	glutamate synthase
THMIRH_RS01210	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
THMIRH_RS01225	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
THMIRH_RS01230	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
THMIRH_RS01235	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
THMIRH_RS01240	COG0167	dihydroorotate dehydrogenase activity
THMIRH_RS01245	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
THMIRH_RS01280	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
THMIRH_RS01290	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THMIRH_RS01310	COG0552	protein localization to endoplasmic reticulum
THMIRH_RS01315	COG0612	Peptidase, M16
THMIRH_RS01320	COG0612	Peptidase, M16
THMIRH_RS01325	COG0840	transmembrane signaling receptor activity
THMIRH_RS01345	COG0742	ribosomal rna small subunit methyltransferase
THMIRH_RS01360	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
THMIRH_RS01390	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
THMIRH_RS01405	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
THMIRH_RS01410	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
THMIRH_RS01420	COG3706	GGDEF domain
THMIRH_RS01430	COG0227	Belongs to the bacterial ribosomal protein bL28 family
THMIRH_RS01440	COG2003	Belongs to the UPF0758 family
THMIRH_RS01455	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THMIRH_RS01460	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
THMIRH_RS01480	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
THMIRH_RS01505	COG2199	diguanylate cyclase activity
THMIRH_RS01505	COG2200	EAL domain
THMIRH_RS01505	COG3287	FIST C domain
THMIRH_RS01515	COG0756	dUTP diphosphatase activity
THMIRH_RS01535	COG3347	Dehydrogenase
THMIRH_RS01535	COG1028	Short-chain dehydrogenase reductase Sdr
THMIRH_RS01560	COG0745	RESPONSE REGULATOR receiver
THMIRH_RS01565	COG1666	GTP binding
THMIRH_RS01570	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THMIRH_RS01580	COG0840	transmembrane signaling receptor activity
THMIRH_RS01580	COG0840	transmembrane signaling receptor activity
THMIRH_RS01595	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
THMIRH_RS01605	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
THMIRH_RS01610	COG0248	Ppx GppA phosphatase
THMIRH_RS01620	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
THMIRH_RS01635	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
THMIRH_RS01645	COG1012	belongs to the aldehyde dehydrogenase family
THMIRH_RS01655	COG0513	Belongs to the DEAD box helicase family
THMIRH_RS01660	COG1611	Belongs to the LOG family
THMIRH_RS01665	COG0628	permease
THMIRH_RS01675	COG1469	GTP cyclohydrolase I activity
THMIRH_RS01680	COG0523	cobalamin synthesis protein
THMIRH_RS01685	COG0579	oxidoreductase
THMIRH_RS01690	COG0640	Transcriptional regulator
THMIRH_RS01695	COG0701	Predicted permease
THMIRH_RS01705	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
THMIRH_RS01720	COG1187	pseudouridine synthase activity
THMIRH_RS01725	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
THMIRH_RS01735	COG1253	flavin adenine dinucleotide binding
THMIRH_RS01745	COG4804	nuclease activity
THMIRH_RS01760	COG0742	ribosomal rna small subunit methyltransferase
THMIRH_RS01770	COG0509	glycine decarboxylation via glycine cleavage system
THMIRH_RS01790	COG0019	diaminopimelate decarboxylase activity
THMIRH_RS01800	COG0400	carboxylic ester hydrolase activity
THMIRH_RS01830	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
THMIRH_RS01845	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
THMIRH_RS01860	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
THMIRH_RS01865	COG0840	transmembrane signaling receptor activity
THMIRH_RS01870	COG0746	molybdenum cofactor guanylyltransferase activity
THMIRH_RS01880	COG2814	Major facilitator Superfamily
THMIRH_RS01885	COG2205	protein histidine kinase activity
THMIRH_RS01885	COG0784	Response regulator, receiver
THMIRH_RS01895	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
THMIRH_RS01895	COG4651	solute:proton antiporter activity
THMIRH_RS01900	COG0589	response to stress
THMIRH_RS01905	COG1620	l-lactate permease
THMIRH_RS01925	COG0142	geranyltranstransferase activity
THMIRH_RS01930	COG0261	This protein binds to 23S rRNA in the presence of protein L20
THMIRH_RS01935	COG0211	Belongs to the bacterial ribosomal protein bL27 family
THMIRH_RS01940	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THMIRH_RS01945	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
THMIRH_RS01950	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THMIRH_RS01955	COG0459	protein refolding
THMIRH_RS01960	COG3706	GGDEF domain
THMIRH_RS01965	COG0210	DNA helicase
THMIRH_RS01975	COG2813	Specifically methylates the guanine in position
THMIRH_RS01990	COG0585	pseudouridine synthase activity
THMIRH_RS01995	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
THMIRH_RS02005	COG0791	NLP P60 protein
THMIRH_RS02020	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
THMIRH_RS02025	COG3100	YcgL domain-containing protein
THMIRH_RS02035	COG0617	tRNA 3'-terminal CCA addition
THMIRH_RS02055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THMIRH_RS02060	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
THMIRH_RS02065	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
THMIRH_RS02070	COG0126	phosphoglycerate kinase activity
THMIRH_RS02075	COG0469	pyruvate kinase activity
THMIRH_RS02105	COG1459	type II secretion system
THMIRH_RS02155	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
THMIRH_RS02160	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
THMIRH_RS02170	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
THMIRH_RS02175	COG0546	phosphoglycolate phosphatase activity
THMIRH_RS02190	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THMIRH_RS02195	COG0134	indole-3-glycerol-phosphate synthase activity
THMIRH_RS02200	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
THMIRH_RS02205	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THMIRH_RS02215	COG1765	OsmC-like protein
THMIRH_RS02225	COG0513	Belongs to the DEAD box helicase family
THMIRH_RS02230	COG1278	Cold shock
THMIRH_RS02235	COG0564	pseudouridine synthase activity
THMIRH_RS02255	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THMIRH_RS02265	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THMIRH_RS02275	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
THMIRH_RS02280	COG0081	regulation of translation
THMIRH_RS02285	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
THMIRH_RS02295	COG0085	RNA polymerase activity
THMIRH_RS02300	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
THMIRH_RS02305	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
THMIRH_RS02310	COG0049	tRNA binding
THMIRH_RS02315	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THMIRH_RS02320	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THMIRH_RS02325	COG0051	transcription antitermination factor activity, RNA binding
THMIRH_RS02330	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
THMIRH_RS02335	COG0088	Forms part of the polypeptide exit tunnel
THMIRH_RS02340	COG0089	rRNA binding
THMIRH_RS02345	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
THMIRH_RS02350	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
THMIRH_RS02355	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
THMIRH_RS02360	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
THMIRH_RS02365	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
THMIRH_RS02370	COG0255	Belongs to the universal ribosomal protein uL29 family
THMIRH_RS02375	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
THMIRH_RS02380	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
THMIRH_RS02385	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
THMIRH_RS02390	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
THMIRH_RS02395	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
THMIRH_RS02400	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
THMIRH_RS02405	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
THMIRH_RS02410	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
THMIRH_RS02415	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
THMIRH_RS02420	COG1841	ribosomal large subunit assembly
THMIRH_RS02425	COG0200	Binds to the 23S rRNA
THMIRH_RS02430	COG0201	protein transport
THMIRH_RS02435	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
THMIRH_RS02440	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
THMIRH_RS02445	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
THMIRH_RS02450	COG0202	RNA polymerase activity
THMIRH_RS02455	COG0203	ribosomal protein L17
THMIRH_RS02465	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
THMIRH_RS02505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
THMIRH_RS02510	COG0540	Belongs to the ATCase OTCase family
THMIRH_RS02515	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
THMIRH_RS02520	COG1678	Uncharacterized ACR, COG1678
THMIRH_RS02525	COG1477	protein flavinylation
THMIRH_RS02540	COG1760	l-serine dehydratase
THMIRH_RS02545	COG0564	pseudouridine synthase activity
THMIRH_RS02560	COG0674	pyruvate-flavodoxin oxidoreductase activity
THMIRH_RS02560	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THMIRH_RS02565	COG1013	pyruvate-flavodoxin oxidoreductase activity
THMIRH_RS02580	COG1714	RDD family
THMIRH_RS02590	COG1074	ATP-dependent DNA helicase activity
THMIRH_RS02600	COG0840	transmembrane signaling receptor activity
THMIRH_RS02610	COG0792	nuclease activity
THMIRH_RS02620	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
THMIRH_RS02625	COG1793	dna ligase
THMIRH_RS02630	COG0436	Aminotransferase
THMIRH_RS02635	COG0556	nucleotide-excision repair
THMIRH_RS02670	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
THMIRH_RS02675	COG0795	lipopolysaccharide-transporting ATPase activity
THMIRH_RS02680	COG0795	lipopolysaccharide-transporting ATPase activity
THMIRH_RS02700	COG0625	glutathione transferase activity
THMIRH_RS02705	COG2969	positive regulation of protein catabolic process
THMIRH_RS02725	COG3425	synthase
THMIRH_RS02730	COG1304	FMN binding
THMIRH_RS02740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THMIRH_RS02745	COG0189	ligase activity
THMIRH_RS02755	COG3706	GGDEF domain
THMIRH_RS02760	COG1385	rRNA (uridine-N3-)-methyltransferase activity
THMIRH_RS02765	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THMIRH_RS02770	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THMIRH_RS02775	COG2199	diguanylate cyclase activity
THMIRH_RS02775	COG2200	EAL domain
THMIRH_RS02780	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
THMIRH_RS02790	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
THMIRH_RS02790	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THMIRH_RS02795	COG1968	undecaprenyl-diphosphatase activity
THMIRH_RS02815	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
THMIRH_RS02820	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THMIRH_RS02825	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
THMIRH_RS02830	COG0828	Belongs to the bacterial ribosomal protein bS21 family
THMIRH_RS02835	COG1610	YqeY-like protein
THMIRH_RS02840	COG0358	DNA primase activity
THMIRH_RS02900	COG2204	response regulator
THMIRH_RS02905	COG5002	protein histidine kinase activity
THMIRH_RS02920	COG0196	riboflavin kinase activity
THMIRH_RS02935	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
THMIRH_RS02940	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
THMIRH_RS02950	COG2951	lytic endotransglycosylase activity
THMIRH_RS02955	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
THMIRH_RS02955	COG0116	Belongs to the methyltransferase superfamily
THMIRH_RS02960	COG2199	diguanylate cyclase activity
THMIRH_RS02980	COG1519	Transferase
THMIRH_RS02985	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
THMIRH_RS02985	COG0517	IMP dehydrogenase activity
THMIRH_RS02995	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
THMIRH_RS02995	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
THMIRH_RS03000	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
THMIRH_RS03010	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
THMIRH_RS03025	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
THMIRH_RS03030	COG0297	glycogen (starch) synthase activity
THMIRH_RS03035	COG0058	SHG alpha-glucan phosphorylase activity
THMIRH_RS03060	COG0745	RESPONSE REGULATOR receiver
THMIRH_RS03065	COG0745	RESPONSE REGULATOR receiver
THMIRH_RS03075	COG0217	transcriptional regulatory protein
THMIRH_RS03120	COG0151	Belongs to the GarS family
THMIRH_RS03125	COG0138	bifunctional purine biosynthesis protein purh
THMIRH_RS03130	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
THMIRH_RS03135	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
THMIRH_RS03140	COG2264	protein methyltransferase activity
THMIRH_RS03145	COG0439	Biotin carboxylase
THMIRH_RS03150	COG0511	ligase activity, forming carbon-carbon bonds
THMIRH_RS03155	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
THMIRH_RS03160	COG4232	protein-disulfide reductase activity
THMIRH_RS03165	COG3030	protein affecting phage T7 exclusion by the F plasmid
THMIRH_RS03185	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THMIRH_RS03210	COG0174	glutamine synthetase
THMIRH_RS03220	COG0581	inorganic phosphate transmembrane transporter activity
THMIRH_RS03225	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THMIRH_RS03230	COG0704	Plays a role in the regulation of phosphate uptake
THMIRH_RS03235	COG0745	RESPONSE REGULATOR receiver
THMIRH_RS03245	COG0306	phosphate transporter
THMIRH_RS03255	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
THMIRH_RS03260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THMIRH_RS03275	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THMIRH_RS03280	COG0523	cobalamin synthesis protein
THMIRH_RS03290	COG1858	cytochrome C peroxidase
THMIRH_RS03310	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
THMIRH_RS03315	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
THMIRH_RS03325	COG2001	Belongs to the MraZ family
THMIRH_RS03330	COG0275	rRNA processing
THMIRH_RS03335	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
THMIRH_RS03355	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
THMIRH_RS03360	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THMIRH_RS03365	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
THMIRH_RS03370	COG0772	Belongs to the SEDS family
THMIRH_RS03375	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THMIRH_RS03390	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
THMIRH_RS03395	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
THMIRH_RS03405	COG0840	transmembrane signaling receptor activity
THMIRH_RS03415	COG3437	response regulator, receiver
THMIRH_RS03420	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THMIRH_RS03425	COG1121	(ABC) transporter
THMIRH_RS03440	COG0719	Fe-S assembly protein
THMIRH_RS03445	COG0396	ATPase activity
THMIRH_RS03450	COG0719	Fe-S assembly protein
THMIRH_RS03455	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THMIRH_RS03475	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THMIRH_RS03480	COG1181	Belongs to the D-alanine--D-alanine ligase family
THMIRH_RS03495	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
THMIRH_RS03505	COG0653	protein targeting
THMIRH_RS03515	COG0352	thiamine-phosphate diphosphorylase activity
THMIRH_RS03520	COG0237	dephospho-CoA kinase activity
THMIRH_RS03535	COG0367	asparagine synthase
THMIRH_RS03540	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
THMIRH_RS03545	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
THMIRH_RS03550	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THMIRH_RS03550	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
THMIRH_RS03555	COG0129	dihydroxy-acid dehydratase activity
THMIRH_RS03565	COG3258	Cytochrome c
THMIRH_RS03585	COG4783	chaperone-mediated protein folding
THMIRH_RS03590	COG0425	Belongs to the sulfur carrier protein TusA family
THMIRH_RS03595	COG2210	Belongs to the sulfur carrier protein TusA family
THMIRH_RS03600	COG1210	Utp--glucose-1-phosphate uridylyltransferase
THMIRH_RS03605	COG0166	Belongs to the GPI family
THMIRH_RS03615	COG1183	phosphatidylcholine synthase activity
THMIRH_RS03620	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THMIRH_RS03630	COG0456	acetyltransferase
THMIRH_RS03635	COG1522	sequence-specific DNA binding
THMIRH_RS03640	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THMIRH_RS03660	COG1959	2 iron, 2 sulfur cluster binding
THMIRH_RS03665	COG0316	Belongs to the HesB IscA family
THMIRH_RS03670	COG0105	UTP biosynthetic process
THMIRH_RS03675	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THMIRH_RS03685	COG0124	histidyl-tRNA synthetase
THMIRH_RS03695	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THMIRH_RS03700	COG1160	GTP binding
THMIRH_RS03725	COG0446	pyridine nucleotide-disulphide oxidoreductase
THMIRH_RS03745	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THMIRH_RS03790	COG4774	siderophore transport
THMIRH_RS03800	COG1418	mRNA catabolic process
THMIRH_RS03805	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THMIRH_RS03810	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
THMIRH_RS03815	COG0291	Belongs to the bacterial ribosomal protein bL35 family
THMIRH_RS03820	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
THMIRH_RS03825	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
THMIRH_RS03830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THMIRH_RS03830	COG0072	phenylalanine-tRNA ligase activity
THMIRH_RS03835	COG0776	regulation of translation
THMIRH_RS03855	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
THMIRH_RS03860	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
THMIRH_RS03865	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
THMIRH_RS03870	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THMIRH_RS03875	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
THMIRH_RS03880	COG3178	'Phosphotransferase
THMIRH_RS03885	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
THMIRH_RS03895	COG3022	response to hydroperoxide
THMIRH_RS03900	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
THMIRH_RS03905	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
THMIRH_RS03910	COG0321	lipoyl(octanoyl) transferase activity
THMIRH_RS03915	COG2921	Belongs to the UPF0250 family
THMIRH_RS03925	COG1686	Belongs to the peptidase S11 family
THMIRH_RS03930	COG0772	Belongs to the SEDS family
THMIRH_RS03935	COG0768	penicillin binding
THMIRH_RS03945	COG1792	Involved in formation and maintenance of cell shape
THMIRH_RS03950	COG1077	Cell shape determining protein MreB Mrl
THMIRH_RS03955	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THMIRH_RS03960	COG0154	amidase activity
THMIRH_RS03965	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THMIRH_RS03970	COG2363	Small membrane protein
THMIRH_RS03975	COG0501	Belongs to the peptidase M48B family
THMIRH_RS03980	COG2166	iron-sulfur cluster assembly
THMIRH_RS03985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THMIRH_RS03990	COG0560	Phosphoserine phosphatase
THMIRH_RS04010	COG0517	IMP dehydrogenase activity
THMIRH_RS04010	COG0516	GMP reductase activity
THMIRH_RS04015	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THMIRH_RS04015	COG0519	Catalyzes the synthesis of GMP from XMP
THMIRH_RS04025	COG2801	Transposase and inactivated derivatives
THMIRH_RS04030	COG0582	viral genome integration into host DNA
THMIRH_RS04040	COG2801	Transposase and inactivated derivatives
THMIRH_RS04045	COG2801	Transposase and inactivated derivatives
THMIRH_RS04065	COG0590	tRNA wobble adenosine to inosine editing
THMIRH_RS04070	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
THMIRH_RS04075	COG2198	Histidine kinase
THMIRH_RS04075	COG0643	Histidine kinase
THMIRH_RS04090	COG0326	Molecular chaperone. Has ATPase activity
THMIRH_RS04115	COG0835	chemotaxis
THMIRH_RS04115	COG0784	Response regulator, receiver
THMIRH_RS04125	COG1815	bacterial-type flagellum-dependent cell motility
THMIRH_RS04130	COG1558	bacterial-type flagellum-dependent cell motility
THMIRH_RS04135	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
THMIRH_RS04140	COG1749	Flagellar hook protein flgE
THMIRH_RS04145	COG4786	Flagellar basal body rod
THMIRH_RS04150	COG4786	Flagellar basal body rod
THMIRH_RS04155	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
THMIRH_RS04160	COG1706	bacterial-type flagellum-dependent cell motility
THMIRH_RS04195	COG2801	Transposase and inactivated derivatives
THMIRH_RS04200	COG2801	Transposase and inactivated derivatives
THMIRH_RS04205	COG1086	Polysaccharide biosynthesis protein
THMIRH_RS04225	COG1083	cytidylyl-transferase
THMIRH_RS04250	COG1028	Short-chain dehydrogenase reductase Sdr
THMIRH_RS04260	COG2089	acid synthase
THMIRH_RS04265	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
THMIRH_RS04275	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
THMIRH_RS04310	COG4372	Transposase
THMIRH_RS04320	COG3328	transposase activity
THMIRH_RS04330	COG2244	polysaccharide biosynthetic process
THMIRH_RS04340	COG0574	Belongs to the PEP-utilizing enzyme family
THMIRH_RS04340	COG3848	Pyruvate phosphate dikinase
THMIRH_RS04345	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
THMIRH_RS04355	COG1213	nucleotidyl transferase
THMIRH_RS04380	COG1215	transferase activity, transferring glycosyl groups
THMIRH_RS04395	COG2604	Protein of unknown function DUF115
THMIRH_RS04405	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THMIRH_RS04415	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THMIRH_RS04430	COG1516	flagellar protein fliS
THMIRH_RS04445	COG3852	Histidine kinase
THMIRH_RS04455	COG1677	Flagellar hook-basal body complex protein FliE
THMIRH_RS04465	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THMIRH_RS04495	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
THMIRH_RS04500	COG1360	Flagellar Motor Protein
THMIRH_RS04525	COG1338	Plays a role in the flagellum-specific transport system
THMIRH_RS04545	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THMIRH_RS04570	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
THMIRH_RS04575	COG2198	Histidine kinase
THMIRH_RS04575	COG0784	Response regulator, receiver
THMIRH_RS04575	COG0643	Histidine kinase
THMIRH_RS04580	COG0835	chemotaxis
THMIRH_RS04585	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
THMIRH_RS04600	COG1090	epimerase
THMIRH_RS04605	COG0415	Belongs to the DNA photolyase family
THMIRH_RS04630	COG0259	pyridoxamine-phosphate oxidase activity
THMIRH_RS04645	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THMIRH_RS04650	COG2202	Pas domain
THMIRH_RS04650	COG1366	Belongs to the anti-sigma-factor antagonist family
THMIRH_RS04655	COG0789	Transcriptional regulator
THMIRH_RS04660	COG0415	Belongs to the DNA photolyase family
THMIRH_RS04675	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
THMIRH_RS04685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THMIRH_RS04690	COG1028	Short-chain dehydrogenase reductase Sdr
THMIRH_RS04710	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
THMIRH_RS04725	COG3118	belongs to the thioredoxin family
THMIRH_RS04735	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THMIRH_RS04765	COG1346	cytolysis
THMIRH_RS04770	COG0205	6-phosphofructokinase activity
THMIRH_RS04775	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
THMIRH_RS04780	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THMIRH_RS04790	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
THMIRH_RS04795	COG0343	queuine tRNA-ribosyltransferase activity
THMIRH_RS04800	COG1862	Preprotein translocase
THMIRH_RS04805	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THMIRH_RS04810	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THMIRH_RS04815	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
THMIRH_RS04820	COG0668	transmembrane transport
THMIRH_RS04830	COG2239	Acts as a magnesium transporter
THMIRH_RS04840	COG1137	ATPase activity
THMIRH_RS04855	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
THMIRH_RS04870	COG1127	ABC transporter
THMIRH_RS04875	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
THMIRH_RS04880	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
THMIRH_RS04895	COG1131	(ABC) transporter
THMIRH_RS04900	COG0842	Transport permease protein
THMIRH_RS04910	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THMIRH_RS04915	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
THMIRH_RS04920	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
THMIRH_RS04925	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
THMIRH_RS04930	COG0723	plastoquinol--plastocyanin reductase activity
THMIRH_RS04935	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
THMIRH_RS04940	COG2857	Cytochrome c1
THMIRH_RS04945	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
THMIRH_RS04950	COG2198	Histidine kinase
THMIRH_RS04950	COG0784	Response regulator, receiver
THMIRH_RS04950	COG5002	protein histidine kinase activity
THMIRH_RS04960	COG4536	flavin adenine dinucleotide binding
THMIRH_RS04970	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THMIRH_RS04980	COG1051	belongs to the nudix hydrolase family
THMIRH_RS04990	COG0508	dehydrogenase complex catalyzes the overall conversion of
THMIRH_RS04995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THMIRH_RS05005	COG0513	Belongs to the DEAD box helicase family
THMIRH_RS05010	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
THMIRH_RS05015	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
THMIRH_RS05020	COG0513	Belongs to the DEAD box helicase family
THMIRH_RS05045	COG0564	pseudouridine synthase activity
THMIRH_RS05065	COG4095	Psort location CytoplasmicMembrane, score
THMIRH_RS05070	COG1280	lysine exporter protein (LysE YggA)
THMIRH_RS05075	COG1902	pentaerythritol trinitrate reductase activity
THMIRH_RS05085	COG1720	tRNA m6t6A37 methyltransferase activity
THMIRH_RS05095	COG1741	Belongs to the pirin family
THMIRH_RS05100	COG0583	DNA-binding transcription factor activity
THMIRH_RS05115	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
THMIRH_RS05120	COG0420	3'-5' exonuclease activity
THMIRH_RS05125	COG0419	ATPase involved in DNA repair
THMIRH_RS05170	COG3300	MHYT domain
THMIRH_RS05170	COG5001	Diguanylate cyclase
THMIRH_RS05175	COG0488	(ABC) transporter
THMIRH_RS05180	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
THMIRH_RS05185	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THMIRH_RS05190	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THMIRH_RS05190	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THMIRH_RS05205	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
THMIRH_RS05210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THMIRH_RS05215	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
THMIRH_RS05220	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
THMIRH_RS05230	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
THMIRH_RS05240	COG0720	synthase
THMIRH_RS05245	COG0142	geranyltranstransferase activity
THMIRH_RS05250	COG0450	alkyl hydroperoxide reductase
THMIRH_RS05265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THMIRH_RS05275	COG0784	Response regulator, receiver
THMIRH_RS05275	COG2205	protein histidine kinase activity
THMIRH_RS05285	COG2801	Transposase and inactivated derivatives
THMIRH_RS05290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
THMIRH_RS05310	COG0745	RESPONSE REGULATOR receiver
THMIRH_RS05315	COG0835	chemotaxis
THMIRH_RS05330	COG2201	protein-glutamate methylesterase activity
THMIRH_RS05355	COG0492	ferredoxin-NADP+ reductase activity
THMIRH_RS05360	COG1674	ftsk spoiiie
THMIRH_RS05365	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
THMIRH_RS05370	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
THMIRH_RS05375	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THMIRH_RS05380	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
THMIRH_RS05395	COG1546	Belongs to the CinA family
THMIRH_RS05400	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
THMIRH_RS05410	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
THMIRH_RS05435	COG4221	oxidoreductase activity
THMIRH_RS05450	COG0564	pseudouridine synthase activity
THMIRH_RS05455	COG2983	Belongs to the UPF0260 family
THMIRH_RS05465	COG0243	molybdopterin cofactor binding
THMIRH_RS05500	COG0489	protein tyrosine kinase activity
THMIRH_RS05510	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
THMIRH_RS05560	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
THMIRH_RS05570	COG2205	protein histidine kinase activity
THMIRH_RS05575	COG0745	RESPONSE REGULATOR receiver
THMIRH_RS05590	COG5001	Diguanylate cyclase
THMIRH_RS05590	COG3300	MHYT domain
THMIRH_RS05600	COG0848	biopolymer transport protein
THMIRH_RS05605	COG0811	peptide transport
THMIRH_RS05615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THMIRH_RS05640	COG0446	pyridine nucleotide-disulphide oxidoreductase
THMIRH_RS05655	COG0574	Belongs to the PEP-utilizing enzyme family
THMIRH_RS05655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THMIRH_RS05660	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
THMIRH_RS05665	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THMIRH_RS05685	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THMIRH_RS05690	COG4660	Part of a membrane complex involved in electron transport
THMIRH_RS05695	COG4659	FMN binding
THMIRH_RS05705	COG4656	Part of a membrane complex involved in electron transport
THMIRH_RS05710	COG2878	Part of a membrane complex involved in electron transport
THMIRH_RS05715	COG4657	Part of a membrane complex involved in electron transport
THMIRH_RS05720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THMIRH_RS05720	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THMIRH_RS05735	COG0564	pseudouridine synthase activity
THMIRH_RS05745	COG0489	protein tyrosine kinase activity
THMIRH_RS05750	COG0717	Belongs to the dCTP deaminase family
THMIRH_RS05760	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
THMIRH_RS05765	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
THMIRH_RS05775	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THMIRH_RS05780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THMIRH_RS05815	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
THMIRH_RS05820	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
THMIRH_RS05835	COG1115	amino acid carrier protein
THMIRH_RS05845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THMIRH_RS05855	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THMIRH_RS05865	COG0545	Peptidyl-prolyl cis-trans isomerase
THMIRH_RS05875	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
THMIRH_RS05880	COG0442	prolyl-tRNA aminoacylation
THMIRH_RS05900	COG0232	Belongs to the dGTPase family. Type 2 subfamily
THMIRH_RS05905	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
THMIRH_RS05915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THMIRH_RS05920	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
THMIRH_RS05940	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
THMIRH_RS05945	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
THMIRH_RS05960	COG0006	proline dipeptidase activity
THMIRH_RS05965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
THMIRH_RS05970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
THMIRH_RS05975	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
THMIRH_RS05980	COG0583	DNA-binding transcription factor activity
THMIRH_RS05985	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
THMIRH_RS05990	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THMIRH_RS05995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THMIRH_RS06005	COG0047	phosphoribosylformylglycinamidine synthase activity
THMIRH_RS06005	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THMIRH_RS06015	COG0322	excinuclease ABC activity
THMIRH_RS06020	COG0667	Aldo Keto reductase
THMIRH_RS06040	COG0837	glucose binding
THMIRH_RS06050	COG3657	addiction module killer protein
THMIRH_RS06075	COG3604	Transcriptional regulator
THMIRH_RS06080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THMIRH_RS06085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THMIRH_RS06090	COG1116	anion transmembrane transporter activity
THMIRH_RS06095	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
THMIRH_RS06110	COG2200	EAL domain
THMIRH_RS06110	COG2202	Pas domain
THMIRH_RS06110	COG2199	diguanylate cyclase activity
THMIRH_RS06125	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
THMIRH_RS06155	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
THMIRH_RS06160	COG0354	folic acid binding
THMIRH_RS06165	COG0835	chemotaxis
THMIRH_RS06180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THMIRH_RS06185	COG0481	GTPase activity
THMIRH_RS06195	COG0571	ribonuclease III activity
THMIRH_RS06205	COG1381	Involved in DNA repair and RecF pathway recombination
THMIRH_RS06210	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
THMIRH_RS06215	COG0736	holo-[acyl-carrier-protein] synthase activity
THMIRH_RS06250	COG3706	GGDEF domain
THMIRH_RS06255	COG1047	Peptidyl-prolyl cis-trans
THMIRH_RS06265	COG0045	succinate-CoA ligase (ADP-forming) activity
THMIRH_RS06275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THMIRH_RS06275	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THMIRH_RS06290	COG3023	N-Acetylmuramoyl-L-alanine amidase
THMIRH_RS06300	COG0716	FMN binding
THMIRH_RS06305	COG2161	toxin-antitoxin pair type II binding
THMIRH_RS06310	COG4115	mRNA cleavage
THMIRH_RS06315	COG1643	Atp-dependent helicase
THMIRH_RS06335	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
THMIRH_RS06340	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
THMIRH_RS06350	COG1376	ErfK ybiS ycfS ynhG family protein
THMIRH_RS06355	COG0601	transmembrane transport
THMIRH_RS06370	COG1472	Belongs to the glycosyl hydrolase 3 family
THMIRH_RS06375	COG0668	transmembrane transport
THMIRH_RS06385	COG0733	neurotransmitter:sodium symporter activity
THMIRH_RS06400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
THMIRH_RS06405	COG1393	Belongs to the ArsC family
THMIRH_RS06410	COG2171	N-acyltransferase activity
THMIRH_RS06415	COG0346	lactoylglutathione lyase activity
THMIRH_RS06440	COG3706	GGDEF domain
THMIRH_RS06455	COG1403	HNH endonuclease
THMIRH_RS06460	COG1525	nuclease
THMIRH_RS06525	COG0322	excinuclease ABC activity
THMIRH_RS06530	COG0616	signal peptide processing
THMIRH_RS06540	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
THMIRH_RS06550	COG0446	pyridine nucleotide-disulphide oxidoreductase
THMIRH_RS06565	COG1136	(ABC) transporter
THMIRH_RS06570	COG0488	(ABC) transporter
THMIRH_RS06575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THMIRH_RS06580	COG0544	peptidyl-prolyl cis-trans isomerase activity
THMIRH_RS06585	COG0740	serine-type endopeptidase activity
THMIRH_RS06590	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
THMIRH_RS06595	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THMIRH_RS06635	COG0601	transmembrane transport
THMIRH_RS06640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THMIRH_RS06650	COG2827	Endonuclease containing a URI domain
THMIRH_RS06660	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
THMIRH_RS06665	COG1570	exodeoxyribonuclease VII activity
THMIRH_RS06675	COG1393	Belongs to the ArsC family
THMIRH_RS06690	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
THMIRH_RS06700	COG0745	RESPONSE REGULATOR receiver
THMIRH_RS06720	COG3012	SEC-C Motif Domain Protein
THMIRH_RS06735	COG0494	nUDIX hydrolase
THMIRH_RS06740	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
THMIRH_RS06750	COG0359	binds to the 23S rRNA
THMIRH_RS06760	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
THMIRH_RS06765	COG0360	Binds together with S18 to 16S ribosomal RNA
THMIRH_RS06770	COG0284	orotidine-5'-phosphate decarboxylase activity
THMIRH_RS06780	COG0776	regulation of translation
THMIRH_RS06795	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
THMIRH_RS06800	COG0287	Prephenate dehydrogenase
THMIRH_RS06805	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THMIRH_RS06810	COG0077	Prephenate dehydratase
THMIRH_RS06810	COG1605	Chorismate mutase
THMIRH_RS06815	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
THMIRH_RS06825	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THMIRH_RS06835	COG1028	Short-chain dehydrogenase reductase Sdr
THMIRH_RS06845	COG1185	polyribonucleotide nucleotidyltransferase activity
THMIRH_RS06850	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
THMIRH_RS06860	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THMIRH_RS06865	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
THMIRH_RS06870	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
THMIRH_RS06875	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
THMIRH_RS06880	COG2251	uridine kinase activity
THMIRH_RS06880	COG0195	Participates in both transcription termination and antitermination
THMIRH_RS06885	COG0779	Required for maturation of 30S ribosomal subunits
THMIRH_RS06905	COG3162	membrane
THMIRH_RS06910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THMIRH_RS06920	COG0747	negative chemotaxis
THMIRH_RS06930	COG2954	triphosphatase activity
THMIRH_RS06960	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
THMIRH_RS06980	COG4206	TonB-dependent receptor
THMIRH_RS06985	COG1492	cobalamin metabolic process
THMIRH_RS07020	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
THMIRH_RS07025	COG2835	tetraacyldisaccharide 4'-kinase activity
THMIRH_RS07030	COG1663	tetraacyldisaccharide 4'-kinase activity
THMIRH_RS07035	COG2333	competence protein COMEC
THMIRH_RS07035	COG0658	competence protein
THMIRH_RS07045	COG1067	ATP-dependent peptidase activity
THMIRH_RS07050	COG0004	ammonium transporteR
THMIRH_RS07065	COG0590	tRNA wobble adenosine to inosine editing
THMIRH_RS07065	COG0037	tRNA processing
THMIRH_RS07070	COG0835	chemotaxis
THMIRH_RS07070	COG0784	Response regulator, receiver
THMIRH_RS07075	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
THMIRH_RS07080	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THMIRH_RS07085	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THMIRH_RS07090	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THMIRH_RS07095	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THMIRH_RS07105	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THMIRH_RS07110	COG0750	zinc metalloprotease
THMIRH_RS07115	COG0575	Belongs to the CDS family
THMIRH_RS07125	COG0233	cytoplasmic translational termination
THMIRH_RS07130	COG0528	UMP kinase activity
THMIRH_RS07135	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
THMIRH_RS07140	COG0052	Belongs to the universal ribosomal protein uS2 family
THMIRH_RS07145	COG0024	Methionine aminopeptidase
THMIRH_RS07150	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
THMIRH_RS07160	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
THMIRH_RS07165	COG2894	cell division
THMIRH_RS07175	COG1049	propionate catabolic process, 2-methylcitrate cycle
THMIRH_RS07200	COG2850	peptidyl-arginine hydroxylation
THMIRH_RS07205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THMIRH_RS07210	COG0363	glucosamine-6-phosphate deaminase activity
THMIRH_RS07215	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
THMIRH_RS07220	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
THMIRH_RS07245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THMIRH_RS07260	COG2900	Belongs to the SlyX family
THMIRH_RS07265	COG0840	transmembrane signaling receptor activity
THMIRH_RS07275	COG1994	Peptidase M50
THMIRH_RS07280	COG0009	L-threonylcarbamoyladenylate synthase
THMIRH_RS07290	COG2205	protein histidine kinase activity
THMIRH_RS07290	COG0784	Response regulator, receiver
THMIRH_RS07295	COG0613	PHP domain protein
THMIRH_RS07300	COG2917	probably involved in intracellular septation
THMIRH_RS07305	COG2350	Protein conserved in bacteria
THMIRH_RS07310	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
THMIRH_RS07320	COG0697	spore germination
THMIRH_RS07330	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THMIRH_RS07335	COG3115	cell septum assembly
THMIRH_RS07340	COG1070	Carbohydrate kinase
THMIRH_RS07345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
THMIRH_RS07350	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
THMIRH_RS07385	COG1643	Atp-dependent helicase
THMIRH_RS07400	COG2204	response regulator
THMIRH_RS07405	COG3852	Histidine kinase
THMIRH_RS07425	COG1929	Belongs to the glycerate kinase type-1 family
THMIRH_RS07440	COG2308	Evidence 4 Homologs of previously reported genes of
THMIRH_RS07450	COG1215	transferase activity, transferring glycosyl groups
THMIRH_RS07460	COG0477	Major facilitator Superfamily
THMIRH_RS07465	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
THMIRH_RS07475	COG0456	acetyltransferase
THMIRH_RS07480	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
THMIRH_RS07485	COG1917	Cupin 2, conserved barrel domain protein
THMIRH_RS07500	COG0840	transmembrane signaling receptor activity
THMIRH_RS07500	COG0840	transmembrane signaling receptor activity
THMIRH_RS07505	COG2199	diguanylate cyclase activity
THMIRH_RS07505	COG2200	EAL domain
THMIRH_RS07510	COG1116	anion transmembrane transporter activity
THMIRH_RS07520	COG1116	anion transmembrane transporter activity
THMIRH_RS07520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THMIRH_RS07525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THMIRH_RS07525	COG1116	anion transmembrane transporter activity
THMIRH_RS07535	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THMIRH_RS07540	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
THMIRH_RS07540	COG1648	precorrin-2 dehydrogenase activity
THMIRH_RS07545	COG0243	molybdopterin cofactor binding
THMIRH_RS07550	COG0840	transmembrane signaling receptor activity
THMIRH_RS07550	COG0840	transmembrane signaling receptor activity
THMIRH_RS07555	COG2146	nitrite reductase [NAD(P)H] activity
THMIRH_RS07555	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THMIRH_RS07560	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THMIRH_RS07565	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THMIRH_RS07585	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
THMIRH_RS07590	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
THMIRH_RS07600	COG0823	Involved in the tonB-independent uptake of proteins
THMIRH_RS07620	COG2255	four-way junction helicase activity
THMIRH_RS07625	COG0632	four-way junction helicase activity
THMIRH_RS07630	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
THMIRH_RS07635	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
THMIRH_RS07640	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
THMIRH_RS07650	COG0300	oxidoreductase activity
THMIRH_RS07655	COG1752	Esterase of the alpha-beta hydrolase superfamily
THMIRH_RS07665	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THMIRH_RS07665	COG1116	anion transmembrane transporter activity
THMIRH_RS07675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THMIRH_RS07690	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THMIRH_RS07705	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
THMIRH_RS07715	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
THMIRH_RS07725	COG0436	Aminotransferase
THMIRH_RS07740	COG1238	metal cluster binding
THMIRH_RS07745	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THMIRH_RS07750	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
THMIRH_RS07755	COG2840	Smr protein MutS2
THMIRH_RS07760	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
THMIRH_RS07765	COG0148	phosphopyruvate hydratase activity
THMIRH_RS07770	COG2877	3-deoxy-8-phosphooctulonate synthase activity
THMIRH_RS07775	COG0504	CTP synthase activity
THMIRH_RS07780	COG0037	tRNA processing
THMIRH_RS07785	COG0825	malonyl-CoA metabolic process
THMIRH_RS07790	COG1944	ATP diphosphatase activity
THMIRH_RS07810	COG1199	ATP-dependent helicase activity
THMIRH_RS07815	COG0257	Belongs to the bacterial ribosomal protein bL36 family
THMIRH_RS07820	COG0542	response to heat
THMIRH_RS07825	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
THMIRH_RS07830	COG0484	heat shock protein binding
THMIRH_RS07835	COG2824	Alkylphosphonate utilization operon protein PhnA
THMIRH_RS07850	COG2996	Protein conserved in bacteria
THMIRH_RS07865	COG1187	pseudouridine synthase activity
THMIRH_RS07870	COG0482	sulfurtransferase activity
THMIRH_RS07875	COG2915	High frequency lysogenization protein hflD homolog
THMIRH_RS07885	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THMIRH_RS07890	COG0745	RESPONSE REGULATOR receiver
THMIRH_RS07895	COG0840	transmembrane signaling receptor activity
THMIRH_RS07905	COG1132	(ABC) transporter
THMIRH_RS07910	COG0084	hydrolase, TatD family'
THMIRH_RS07915	COG0470	DNA polymerase III
THMIRH_RS07920	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
THMIRH_RS07925	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
THMIRH_RS07930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
THMIRH_RS07935	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
THMIRH_RS07940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THMIRH_RS07945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THMIRH_RS07955	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
THMIRH_RS07960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THMIRH_RS07965	COG0416	fatty acid biosynthetic process
THMIRH_RS07970	COG0333	Belongs to the bacterial ribosomal protein bL32 family
THMIRH_RS07980	COG0424	maF-like protein
THMIRH_RS07990	COG0564	pseudouridine synthase activity
THMIRH_RS07995	COG1530	ribonuclease E activity
THMIRH_RS08000	COG0215	cysteine-tRNA ligase activity
THMIRH_RS08010	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
THMIRH_RS08020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THMIRH_RS08035	COG1301	dicarboxylic acid transport
THMIRH_RS08040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THMIRH_RS08045	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
THMIRH_RS08050	COG0137	argininosuccinate synthase activity
THMIRH_RS08055	COG0688	phosphatidylethanolamine metabolic process
THMIRH_RS08060	COG0347	Belongs to the P(II) protein family
THMIRH_RS08065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
THMIRH_RS08070	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
THMIRH_RS08080	COG0330	HflC and HflK could
THMIRH_RS08085	COG0330	HflC and HflK could
THMIRH_RS08090	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
THMIRH_RS08095	COG1923	regulation of RNA biosynthetic process
THMIRH_RS08100	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
THMIRH_RS08105	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
THMIRH_RS08115	COG0802	atpase or kinase
THMIRH_RS08165	COG1940	carbohydrate kinase activity
THMIRH_RS08175	COG2833	Protein of unknown function (DUF455)
THMIRH_RS08185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
THMIRH_RS08195	COG0505	Belongs to the CarA family
THMIRH_RS08210	COG4628	conserved protein (DUF2132)
THMIRH_RS08220	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
THMIRH_RS08225	COG0484	heat shock protein binding
THMIRH_RS08230	COG0443	Heat shock 70 kDa protein
THMIRH_RS08235	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THMIRH_RS08240	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
THMIRH_RS08245	COG0497	DNA recombination
THMIRH_RS08260	COG0735	belongs to the Fur family
THMIRH_RS08270	COG2914	Belongs to the UPF0125 (RnfH) family
THMIRH_RS08275	COG2867	negative regulation of translational initiation
THMIRH_RS08280	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
THMIRH_RS08290	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
THMIRH_RS08300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THMIRH_RS08310	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THMIRH_RS08325	COG2186	Transcriptional regulator
THMIRH_RS08330	COG2351	hydroxyisourate hydrolase activity
THMIRH_RS08335	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
THMIRH_RS08340	COG1529	Aldehyde oxidase and xanthine dehydrogenase
THMIRH_RS08345	COG3608	succinylglutamate desuccinylase aspartoacylase
THMIRH_RS08345	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
THMIRH_RS08350	COG0590	tRNA wobble adenosine to inosine editing
THMIRH_RS08375	COG1116	anion transmembrane transporter activity
THMIRH_RS08380	COG0864	Transcriptional regulator
THMIRH_RS08390	COG3665	Urea carboxylase-associated protein
THMIRH_RS08395	COG0439	Biotin carboxylase
THMIRH_RS08425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THMIRH_RS08445	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
THMIRH_RS08455	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
THMIRH_RS08460	COG0730	response to heat
THMIRH_RS08470	COG0154	amidase activity
THMIRH_RS08475	COG1047	Peptidyl-prolyl cis-trans
THMIRH_RS08480	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
THMIRH_RS08485	COG3706	GGDEF domain
THMIRH_RS08490	COG2801	Transposase and inactivated derivatives
THMIRH_RS08495	COG0328	RNA-DNA hybrid ribonuclease activity
THMIRH_RS08500	COG2226	methyltransferase
THMIRH_RS08505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THMIRH_RS08510	COG1388	LysM domain
THMIRH_RS08510	COG0741	lytic transglycosylase activity
THMIRH_RS08520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THMIRH_RS08525	COG0564	pseudouridine synthase activity
THMIRH_RS08550	COG1007	ATP synthesis coupled electron transport
THMIRH_RS08565	COG0713	ATP synthesis coupled electron transport
THMIRH_RS08575	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THMIRH_RS08580	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
THMIRH_RS08585	COG1034	ATP synthesis coupled electron transport
THMIRH_RS08595	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
THMIRH_RS08600	COG0649	NAD binding
THMIRH_RS08605	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THMIRH_RS08610	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THMIRH_RS08615	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THMIRH_RS08630	COG0149	triose-phosphate isomerase activity
THMIRH_RS08635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THMIRH_RS08640	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
THMIRH_RS08650	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
THMIRH_RS08655	COG1534	Rna-binding protein
THMIRH_RS08675	COG0285	dihydrofolate synthase activity
THMIRH_RS08680	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
THMIRH_RS08685	COG0159	tryptophan synthase activity
THMIRH_RS08695	COG0135	phosphoribosylanthranilate isomerase activity
THMIRH_RS08700	COG0101	tRNA pseudouridine synthase activity
THMIRH_RS08705	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
THMIRH_RS08715	COG0739	heme binding
THMIRH_RS08720	COG0473	3-isopropylmalate dehydrogenase activity
THMIRH_RS08730	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THMIRH_RS08735	COG0602	queuosine metabolic process
THMIRH_RS08740	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
THMIRH_RS08755	COG0189	ligase activity
THMIRH_RS08770	COG2239	Acts as a magnesium transporter
THMIRH_RS08775	COG1253	flavin adenine dinucleotide binding
THMIRH_RS08795	COG3264	Mechanosensitive ion channel
THMIRH_RS08795	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
THMIRH_RS08800	COG0189	ligase activity
THMIRH_RS08810	COG0189	ligase activity
THMIRH_RS08810	COG4067	protein conserved in archaea
THMIRH_RS08820	COG0668	transmembrane transport
THMIRH_RS08835	COG0488	(ABC) transporter
THMIRH_RS08840	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THMIRH_RS08875	COG0308	aminopeptidase N
THMIRH_RS08880	COG2885	chlorophyll binding
THMIRH_RS08885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THMIRH_RS08900	COG0557	exoribonuclease II activity
THMIRH_RS08905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THMIRH_RS08910	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
THMIRH_RS08920	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
THMIRH_RS08925	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
THMIRH_RS08930	COG2814	Major facilitator Superfamily
THMIRH_RS08935	COG0659	secondary active sulfate transmembrane transporter activity
THMIRH_RS08945	COG3123	guanosine phosphorylase activity
THMIRH_RS08960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THMIRH_RS08970	COG2353	YceI-like domain
THMIRH_RS08975	COG3038	cytochrome b561
THMIRH_RS08985	COG2873	o-acetylhomoserine
THMIRH_RS08995	COG2814	Major facilitator Superfamily
THMIRH_RS09005	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
THMIRH_RS09015	COG0268	Binds directly to 16S ribosomal RNA
THMIRH_RS09025	COG1671	Belongs to the UPF0178 family
THMIRH_RS09030	COG0247	lactate metabolic process
THMIRH_RS09030	COG0277	FAD linked oxidase domain protein
THMIRH_RS09035	COG0463	Glycosyl transferase, family 2
THMIRH_RS09050	COG2990	Protein conserved in bacteria
THMIRH_RS09060	COG0859	PFAM glycosyl transferase family 9
THMIRH_RS09065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THMIRH_RS09075	COG1132	(ABC) transporter
THMIRH_RS09080	COG1560	Kdo2-lipid A biosynthetic process
THMIRH_RS09085	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
THMIRH_RS09090	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
THMIRH_RS09095	COG1360	Flagellar Motor Protein
THMIRH_RS09100	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
THMIRH_RS09105	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
THMIRH_RS09110	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
THMIRH_RS09115	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
THMIRH_RS09120	COG0617	tRNA 3'-terminal CCA addition
THMIRH_RS09150	COG0004	ammonium transporteR
THMIRH_RS09160	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THMIRH_RS09165	COG0525	valine-tRNA ligase activity
THMIRH_RS09170	COG4991	sh3 domain protein
THMIRH_RS09175	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
THMIRH_RS09185	COG0335	large ribosomal subunit rRNA binding
THMIRH_RS09190	COG0336	Belongs to the RNA methyltransferase TrmD family
THMIRH_RS09195	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
THMIRH_RS09200	COG0228	four-way junction DNA binding
THMIRH_RS09205	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
THMIRH_RS09215	COG0028	Belongs to the TPP enzyme family
THMIRH_RS09220	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
THMIRH_RS09225	COG0501	Belongs to the peptidase M48B family
THMIRH_RS09230	COG2154	pterin-4-alpha-carbinolamine dehydratase
THMIRH_RS09235	COG1162	GTPase activity
THMIRH_RS09295	COG3267	Type II secretory pathway component ExeA
THMIRH_RS09295	COG3409	Peptidoglycan-binding domain 1 protein
THMIRH_RS09330	COG1530	ribonuclease E activity
THMIRH_RS09335	COG0424	maF-like protein
THMIRH_RS09340	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THMIRH_RS09350	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
THMIRH_RS09355	COG0799	negative regulation of ribosome biogenesis
THMIRH_RS09360	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
THMIRH_RS09370	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
THMIRH_RS09385	COG0495	leucyl-tRNA aminoacylation
THMIRH_RS09395	COG0815	Transfers the fatty acyl group on membrane lipoproteins
THMIRH_RS09400	COG4535	Mg2 and Co2 transporter CorC
THMIRH_RS09405	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
THMIRH_RS09410	COG1702	phosphate starvation-inducible protein PhoH
THMIRH_RS09415	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THMIRH_RS09420	COG0840	transmembrane signaling receptor activity
THMIRH_RS09425	COG3338	carbonate dehydratase activity
THMIRH_RS09435	COG0521	Mo-molybdopterin cofactor biosynthetic process
THMIRH_RS09440	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THMIRH_RS09455	COG4251	negative regulation of phosphorylation
THMIRH_RS09470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THMIRH_RS09480	COG0271	Belongs to the BolA IbaG family
THMIRH_RS09495	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
THMIRH_RS09500	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
THMIRH_RS09505	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THMIRH_RS09515	COG0583	DNA-binding transcription factor activity
THMIRH_RS09525	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
THMIRH_RS09595	COG2239	Acts as a magnesium transporter
THMIRH_RS09605	COG3002	Belongs to the UPF0753 family
THMIRH_RS09610	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THMIRH_RS09630	COG0494	nUDIX hydrolase
THMIRH_RS09635	COG1011	Hydrolase
THMIRH_RS09670	COG0500	methyltransferase
THMIRH_RS09680	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THMIRH_RS09690	COG1178	ABC-type Fe3 transport system permease component
THMIRH_RS09700	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
THMIRH_RS09705	COG0433	COG0433 Predicted ATPase
THMIRH_RS09715	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THMIRH_RS09720	COG0588	phosphoglycerate mutase activity
THMIRH_RS09750	COG1120	ATPase activity
THMIRH_RS09755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THMIRH_RS09760	COG1295	ribonuclease BN
THMIRH_RS09775	COG0693	protein deglycase activity
THMIRH_RS09780	COG0793	Belongs to the peptidase S41A family
THMIRH_RS09785	COG0640	Transcriptional regulator
THMIRH_RS09800	COG1850	ribulose-bisphosphate carboxylase activity
THMIRH_RS09815	COG0288	reversible hydration of carbon dioxide
THMIRH_RS09825	COG2391	methyltransferase activity
THMIRH_RS09830	COG0446	pyridine nucleotide-disulphide oxidoreductase
THMIRH_RS09840	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
THMIRH_RS09855	COG1131	(ABC) transporter
THMIRH_RS09860	COG2223	nitrite transmembrane transporter activity
THMIRH_RS09865	COG0542	response to heat
THMIRH_RS09880	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
THMIRH_RS09905	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
THMIRH_RS09920	COG3328	transposase activity
THMIRH_RS09925	COG0659	secondary active sulfate transmembrane transporter activity
THMIRH_RS09930	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
THMIRH_RS09940	COG2226	methyltransferase
THMIRH_RS09950	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
THMIRH_RS09960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THMIRH_RS09970	COG0840	transmembrane signaling receptor activity
THMIRH_RS09990	COG0012	GTP binding
THMIRH_RS09995	COG0193	aminoacyl-tRNA hydrolase activity
THMIRH_RS10000	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
THMIRH_RS10005	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
THMIRH_RS10020	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
THMIRH_RS10025	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
THMIRH_RS10030	COG2890	protein-(glutamine-N5) methyltransferase activity
THMIRH_RS10035	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
THMIRH_RS10045	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
THMIRH_RS10075	COG0259	pyridoxamine-phosphate oxidase activity
THMIRH_RS10085	COG0840	transmembrane signaling receptor activity
THMIRH_RS10115	COG0751	glycine-tRNA ligase activity
THMIRH_RS10125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THMIRH_RS10125	COG0425	Belongs to the sulfur carrier protein TusA family
THMIRH_RS10130	COG0739	heme binding
THMIRH_RS10135	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
THMIRH_RS10145	COG0316	Belongs to the HesB IscA family
THMIRH_RS10150	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
THMIRH_RS10200	COG2197	response regulator
THMIRH_RS10210	COG0606	chelatase, subunit chli
THMIRH_RS10220	COG3706	GGDEF domain
THMIRH_RS10230	COG0018	arginyl-trna synthetase
THMIRH_RS10240	COG4566	intracellular signal transduction
THMIRH_RS10245	COG0758	DNA mediated transformation
THMIRH_RS10250	COG0242	peptide deformylase activity
THMIRH_RS10255	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THMIRH_RS10270	COG5000	phosphorelay sensor kinase activity
THMIRH_RS10275	COG2204	response regulator
THMIRH_RS10280	COG0569	domain protein
THMIRH_RS10285	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
THMIRH_RS10325	COG0037	tRNA processing
THMIRH_RS10340	COG1596	polysaccharide export
THMIRH_RS10340	COG1555	photosystem II stabilization
THMIRH_RS10345	COG2258	MOSC domain
THMIRH_RS10355	COG0730	response to heat
THMIRH_RS10360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THMIRH_RS10365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THMIRH_RS10415	COG0582	viral genome integration into host DNA
THMIRH_RS10425	COG3328	transposase activity
THMIRH_RS10450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THMIRH_RS10450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
THMIRH_RS10475	COG1216	Glycosyl transferase, family 2
THMIRH_RS10475	COG0438	transferase activity, transferring glycosyl groups
THMIRH_RS10480	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
THMIRH_RS10520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
THMIRH_RS10525	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THMIRH_RS10530	COG0646	methionine synthase
THMIRH_RS10530	COG1410	methionine synthase
THMIRH_RS10540	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
THMIRH_RS10590	COG0315	cyclic pyranopterin monophosphate synthase activity
THMIRH_RS10595	COG0303	'Molybdopterin
THMIRH_RS10600	COG0314	molybdopterin synthase activity
THMIRH_RS10605	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
THMIRH_RS10610	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
THMIRH_RS10620	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
THMIRH_RS10635	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THMIRH_RS10640	COG2203	Gaf domain
THMIRH_RS10640	COG3706	GGDEF domain
THMIRH_RS10640	COG5001	Diguanylate cyclase
THMIRH_RS10640	COG4251	negative regulation of phosphorylation
THMIRH_RS10645	COG0543	2 iron, 2 sulfur cluster binding
THMIRH_RS10645	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
THMIRH_RS10650	COG0708	Exodeoxyribonuclease III
THMIRH_RS10665	COG1136	(ABC) transporter
THMIRH_RS10670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THMIRH_RS10670	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
THMIRH_RS10680	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THMIRH_RS10690	COG2205	protein histidine kinase activity
THMIRH_RS10690	COG0784	Response regulator, receiver
THMIRH_RS10690	COG5002	protein histidine kinase activity
THMIRH_RS10700	COG2081	HI0933 family
THMIRH_RS10710	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
THMIRH_RS10710	COG0678	peroxiredoxin activity
THMIRH_RS10720	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
THMIRH_RS10740	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
THMIRH_RS10745	COG1561	YicC-like family, N-terminal region
THMIRH_RS10760	COG3001	Fructosamine kinase
THMIRH_RS10765	COG0563	adenylate kinase activity
THMIRH_RS10770	COG3706	GGDEF domain
THMIRH_RS10785	COG4181	ATPase activity
THMIRH_RS10790	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
THMIRH_RS10835	COG2200	EAL domain
THMIRH_RS10850	COG0596	Alpha beta hydrolase
THMIRH_RS10880	COG1850	ribulose-bisphosphate carboxylase activity
THMIRH_RS10885	COG0583	DNA-binding transcription factor activity
THMIRH_RS10890	COG0840	transmembrane signaling receptor activity
THMIRH_RS10900	COG0784	Response regulator, receiver
THMIRH_RS10900	COG2205	protein histidine kinase activity
THMIRH_RS10910	COG2200	EAL domain
THMIRH_RS10910	COG2199	diguanylate cyclase activity
THMIRH_RS10910	COG3287	FIST C domain
THMIRH_RS10915	COG4251	negative regulation of phosphorylation
THMIRH_RS10915	COG3706	GGDEF domain
THMIRH_RS10915	COG2203	Gaf domain
THMIRH_RS10915	COG5001	Diguanylate cyclase
THMIRH_RS10925	COG2814	Major facilitator Superfamily
THMIRH_RS10960	COG4206	TonB-dependent receptor
THMIRH_RS10975	COG0840	transmembrane signaling receptor activity
THMIRH_RS11005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THMIRH_RS11015	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
THMIRH_RS11050	COG0390	transport system, permease component
THMIRH_RS11060	COG3040	lipid binding
THMIRH_RS11065	COG4335	DNA alkylation repair
THMIRH_RS11070	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
THMIRH_RS11075	COG0277	FAD linked oxidase domain protein
THMIRH_RS11080	COG0277	FAD linked oxidase domain protein
THMIRH_RS11085	COG0247	lactate metabolic process
THMIRH_RS11090	COG2759	Belongs to the formate--tetrahydrofolate ligase family
THMIRH_RS11095	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
THMIRH_RS11120	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THMIRH_RS11125	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
THMIRH_RS11130	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
THMIRH_RS11135	COG3842	ATPase activity
THMIRH_RS11140	COG1176	ABC-type spermidine putrescine transport system, permease component I
THMIRH_RS11145	COG1177	transmembrane transport
THMIRH_RS11165	COG3437	response regulator, receiver
THMIRH_RS11165	COG0784	Response regulator, receiver
THMIRH_RS11190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THMIRH_RS11220	COG1854	S-ribosylhomocysteine lyase activity
THMIRH_RS11225	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
THMIRH_RS11230	COG0840	transmembrane signaling receptor activity
THMIRH_RS11235	COG3300	MHYT domain
THMIRH_RS11235	COG5001	Diguanylate cyclase
THMIRH_RS11245	COG5002	protein histidine kinase activity
THMIRH_RS11245	COG5001	Diguanylate cyclase
THMIRH_RS11255	COG1444	tRNA N-acetyltransferase activity
THMIRH_RS11260	COG0788	formyltetrahydrofolate deformylase activity
THMIRH_RS11270	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
THMIRH_RS11275	COG0254	rRNA binding
THMIRH_RS11285	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
THMIRH_RS11290	COG0328	RNA-DNA hybrid ribonuclease activity
THMIRH_RS11305	COG0561	phosphatase activity
THMIRH_RS11305	COG3100	YcgL domain-containing protein
THMIRH_RS11310	COG0438	transferase activity, transferring glycosyl groups
THMIRH_RS11330	COG0489	protein tyrosine kinase activity
THMIRH_RS11360	COG0463	Glycosyl transferase, family 2
THMIRH_RS11380	COG0297	glycogen (starch) synthase activity
THMIRH_RS11390	COG2161	toxin-antitoxin pair type II binding
THMIRH_RS11400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THMIRH_RS11405	COG1051	belongs to the nudix hydrolase family
THMIRH_RS11410	COG0662	Cupin 2, conserved barrel domain protein
THMIRH_RS11410	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
THMIRH_RS11420	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
THMIRH_RS11455	COG2205	protein histidine kinase activity
THMIRH_RS11455	COG5002	protein histidine kinase activity
THMIRH_RS11455	COG0784	Response regulator, receiver
THMIRH_RS11460	COG2801	Transposase and inactivated derivatives
THMIRH_RS11605	COG0582	viral genome integration into host DNA
THMIRH_RS11715	COG0582	viral genome integration into host DNA
THMIRH_RS11725	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
THMIRH_RS11750	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
THMIRH_RS11765	COG5001	Diguanylate cyclase
THMIRH_RS11765	COG4251	negative regulation of phosphorylation
THMIRH_RS11765	COG2203	Gaf domain
THMIRH_RS11765	COG3706	GGDEF domain
THMIRH_RS11805	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
THMIRH_RS11805	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
THMIRH_RS11825	COG3220	belongs to the UPF0276 family
THMIRH_RS11830	COG2337	Toxic component of a toxin-antitoxin (TA) module
THMIRH_RS11850	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THMIRH_RS11855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THMIRH_RS11890	COG1487	ribonuclease activity
THMIRH_RS11925	COG0840	transmembrane signaling receptor activity
THMIRH_RS11940	COG1739	Uncharacterized protein family UPF0029
THMIRH_RS11950	COG0840	transmembrane signaling receptor activity
THMIRH_RS11950	COG0840	transmembrane signaling receptor activity
THMIRH_RS11955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THMIRH_RS11960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THMIRH_RS11965	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THMIRH_RS11970	COG2203	Gaf domain
THMIRH_RS11970	COG2199	diguanylate cyclase activity
THMIRH_RS11980	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THMIRH_RS11990	COG0706	membrane insertase activity
THMIRH_RS11995	COG0594	ribonuclease P activity
THMIRH_RS12000	COG0230	Belongs to the bacterial ribosomal protein bL34 family
THMIRH_RS12050	COG0730	response to heat