locus-tag	class	description
FE785_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FE785_RS00010	COG0592	DNA-directed DNA polymerase activity
FE785_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FE785_RS00030	COG0384	phenazine biosynthesis protein PhzF
FE785_RS00035	COG0071	Belongs to the small heat shock protein (HSP20) family
FE785_RS00040	COG0187	DNA topoisomerase II activity
FE785_RS00060	COG0408	coproporphyrinogen oxidase activity
FE785_RS00095	COG4251	negative regulation of phosphorylation
FE785_RS00095	COG3706	GGDEF domain
FE785_RS00095	COG2203	Gaf domain
FE785_RS00095	COG5001	Diguanylate cyclase
FE785_RS00110	COG1187	pseudouridine synthase activity
FE785_RS00115	COG0009	L-threonylcarbamoyladenylate synthase
FE785_RS00120	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FE785_RS00125	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FE785_RS00125	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FE785_RS00130	COG3706	GGDEF domain
FE785_RS00145	COG2207	Transcriptional regulator
FE785_RS00150	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FE785_RS00155	COG1333	cytochrome c biogenesis protein
FE785_RS00160	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FE785_RS00180	COG0514	ATP-dependent DNA helicase (RecQ)
FE785_RS00185	COG0778	Nitroreductase
FE785_RS00195	COG2853	Lipoprotein
FE785_RS00200	COG2111	Na H antiporter
FE785_RS00200	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FE785_RS00205	COG1006	Multisubunit Na H antiporter MnhC subunit
FE785_RS00210	COG0651	ATP synthesis coupled electron transport
FE785_RS00215	COG1863	multisubunit Na H antiporter MnhE subunit
FE785_RS00220	COG2212	antiporter activity
FE785_RS00225	COG1320	monovalent cation:proton antiporter activity
FE785_RS00230	COG2391	methyltransferase activity
FE785_RS00245	COG1522	sequence-specific DNA binding
FE785_RS00250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FE785_RS00265	COG0432	Pfam Uncharacterised protein family UPF0047
FE785_RS00270	COG0339	signal peptide processing
FE785_RS00305	COG0318	PFAM AMP-dependent synthetase and ligase
FE785_RS00305	COG0204	Acyl-transferase
FE785_RS00315	COG2304	oxidoreductase activity
FE785_RS00335	COG0714	Associated with various cellular activities
FE785_RS00340	COG0247	lactate metabolic process
FE785_RS00345	COG0277	FAD linked oxidase domain protein
FE785_RS00350	COG0277	FAD linked oxidase domain protein
FE785_RS00355	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FE785_RS00360	COG2200	EAL domain
FE785_RS00365	COG1643	Atp-dependent helicase
FE785_RS00375	COG0500	methyltransferase
FE785_RS00380	COG2226	methyltransferase
FE785_RS00390	COG0741	lytic transglycosylase activity
FE785_RS00405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FE785_RS00410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FE785_RS00430	COG0714	Associated with various cellular activities
FE785_RS00465	COG3118	belongs to the thioredoxin family
FE785_RS00485	COG0515	serine threonine protein kinase
FE785_RS00485	COG3266	domain, Protein
FE785_RS00495	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FE785_RS00505	COG0165	Argininosuccinate lyase
FE785_RS00515	COG0181	hydroxymethylbilane synthase activity
FE785_RS00550	COG0788	formyltetrahydrofolate deformylase activity
FE785_RS00555	COG1444	tRNA N-acetyltransferase activity
FE785_RS00565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FE785_RS00565	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FE785_RS00580	COG1058	Belongs to the CinA family
FE785_RS00580	COG1546	Belongs to the CinA family
FE785_RS00585	COG2081	HI0933 family
FE785_RS00595	COG0583	DNA-binding transcription factor activity
FE785_RS00600	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FE785_RS00625	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FE785_RS00625	COG0678	peroxiredoxin activity
FE785_RS00655	COG1840	ABC-type Fe3 transport system, periplasmic component
FE785_RS00660	COG1858	cytochrome C peroxidase
FE785_RS00675	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FE785_RS00680	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FE785_RS00685	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FE785_RS00705	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FE785_RS00710	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FE785_RS00715	COG0314	molybdopterin synthase activity
FE785_RS00720	COG0303	'Molybdopterin
FE785_RS00725	COG0315	cyclic pyranopterin monophosphate synthase activity
FE785_RS00730	COG3706	GGDEF domain
FE785_RS00735	COG2827	Endonuclease containing a URI domain
FE785_RS00750	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FE785_RS00765	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FE785_RS00770	COG2226	methyltransferase
FE785_RS00775	COG0596	Alpha beta hydrolase
FE785_RS00785	COG0156	8-amino-7-oxononanoate synthase activity
FE785_RS00790	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FE785_RS00795	COG1040	competence protein
FE785_RS00820	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FE785_RS00825	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FE785_RS00830	COG0537	adenosine 5'-monophosphoramidase activity
FE785_RS00835	COG0140	phosphoribosyl-ATP diphosphatase activity
FE785_RS00840	COG0107	imidazoleglycerol-phosphate synthase activity
FE785_RS00845	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FE785_RS00850	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FE785_RS00855	COG0131	Imidazoleglycerol-phosphate dehydratase
FE785_RS00860	COG3278	Belongs to the heme-copper respiratory oxidase family
FE785_RS00875	COG2010	Cytochrome c
FE785_RS00880	COG0348	domain, Protein
FE785_RS00890	COG2217	Heavy metal translocating P-type atpase
FE785_RS00920	COG1490	D-aminoacyl-tRNA deacylase activity
FE785_RS00930	COG1217	gtp-binding protein TYPA
FE785_RS00940	COG2391	methyltransferase activity
FE785_RS00950	COG1960	acyl-CoA dehydrogenase activity
FE785_RS00975	COG0646	methionine synthase
FE785_RS00975	COG1410	methionine synthase
FE785_RS00980	COG0840	transmembrane signaling receptor activity
FE785_RS00985	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FE785_RS00995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FE785_RS00995	COG4191	Histidine kinase
FE785_RS01005	COG3437	response regulator, receiver
FE785_RS01005	COG0784	Response regulator, receiver
FE785_RS01010	COG0037	tRNA processing
FE785_RS01035	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FE785_RS01040	COG0569	domain protein
FE785_RS01045	COG2204	response regulator
FE785_RS01050	COG5000	phosphorelay sensor kinase activity
FE785_RS01060	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FE785_RS01065	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FE785_RS01070	COG0242	peptide deformylase activity
FE785_RS01075	COG0758	DNA mediated transformation
FE785_RS01090	COG0018	arginyl-trna synthetase
FE785_RS01105	COG2960	long-chain fatty acid transporting porin activity
FE785_RS01110	COG0606	chelatase, subunit chli
FE785_RS01125	COG2197	response regulator
FE785_RS01130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FE785_RS01140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FE785_RS01160	COG1454	alcohol dehydrogenase
FE785_RS01165	COG0210	DNA helicase
FE785_RS01170	COG3437	response regulator, receiver
FE785_RS01170	COG0784	Response regulator, receiver
FE785_RS01175	COG2813	Specifically methylates the guanine in position
FE785_RS01195	COG0585	pseudouridine synthase activity
FE785_RS01200	COG0784	Response regulator, receiver
FE785_RS01200	COG2205	protein histidine kinase activity
FE785_RS01200	COG5002	protein histidine kinase activity
FE785_RS01205	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FE785_RS01215	COG1929	Belongs to the glycerate kinase type-1 family
FE785_RS01235	COG3100	YcgL domain-containing protein
FE785_RS01245	COG0617	tRNA 3'-terminal CCA addition
FE785_RS01250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FE785_RS01260	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FE785_RS01265	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FE785_RS01270	COG0126	phosphoglycerate kinase activity
FE785_RS01285	COG0840	transmembrane signaling receptor activity
FE785_RS01320	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
FE785_RS01325	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
FE785_RS01330	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
FE785_RS01345	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FE785_RS01350	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
FE785_RS01355	COG0583	DNA-binding transcription factor activity
FE785_RS01360	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FE785_RS01365	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FE785_RS01375	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FE785_RS01380	COG0546	phosphoglycolate phosphatase activity
FE785_RS01385	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FE785_RS01390	COG0512	Glutamine amidotransferase of anthranilate synthase
FE785_RS01395	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FE785_RS01400	COG0134	indole-3-glycerol-phosphate synthase activity
FE785_RS01405	COG0133	tryptophan synthase activity
FE785_RS01425	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
FE785_RS01430	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FE785_RS01440	COG1765	OsmC-like protein
FE785_RS01465	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FE785_RS01470	COG0564	pseudouridine synthase activity
FE785_RS01490	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FE785_RS01500	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FE785_RS01510	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FE785_RS01515	COG0081	regulation of translation
FE785_RS01520	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FE785_RS01525	COG0222	ribosome binding
FE785_RS01530	COG0085	RNA polymerase activity
FE785_RS01535	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FE785_RS01540	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FE785_RS01545	COG0049	tRNA binding
FE785_RS01550	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FE785_RS01555	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FE785_RS01560	COG0051	transcription antitermination factor activity, RNA binding
FE785_RS01565	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FE785_RS01570	COG0088	Forms part of the polypeptide exit tunnel
FE785_RS01575	COG0089	rRNA binding
FE785_RS01580	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FE785_RS01585	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FE785_RS01590	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FE785_RS01595	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FE785_RS01600	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FE785_RS01605	COG0255	Belongs to the universal ribosomal protein uL29 family
FE785_RS01610	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FE785_RS01615	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FE785_RS01620	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FE785_RS01625	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FE785_RS01630	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FE785_RS01635	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FE785_RS01640	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FE785_RS01645	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FE785_RS01650	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FE785_RS01655	COG1841	ribosomal large subunit assembly
FE785_RS01660	COG0200	Binds to the 23S rRNA
FE785_RS01665	COG0201	protein transport
FE785_RS01670	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FE785_RS01675	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FE785_RS01680	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FE785_RS01685	COG0202	RNA polymerase activity
FE785_RS01690	COG0203	ribosomal protein L17
FE785_RS01695	COG0084	hydrolase, TatD family'
FE785_RS01700	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FE785_RS01725	COG2814	Major facilitator Superfamily
FE785_RS01730	COG0629	single-stranded DNA binding
FE785_RS01740	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FE785_RS01745	COG3002	Belongs to the UPF0753 family
FE785_RS01755	COG0527	aspartate kinase activity
FE785_RS01760	COG1917	Cupin 2, conserved barrel domain protein
FE785_RS01765	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FE785_RS01785	COG0142	geranyltranstransferase activity
FE785_RS01790	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FE785_RS01795	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FE785_RS01800	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FE785_RS01805	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FE785_RS01810	COG0840	transmembrane signaling receptor activity
FE785_RS01815	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FE785_RS01820	COG0459	protein refolding
FE785_RS01830	COG3706	GGDEF domain
FE785_RS01845	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FE785_RS01865	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
FE785_RS01870	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
FE785_RS01885	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FE785_RS01890	COG0316	Belongs to the HesB IscA family
FE785_RS01900	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FE785_RS01905	COG0739	heme binding
FE785_RS01910	COG0425	Belongs to the sulfur carrier protein TusA family
FE785_RS01910	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FE785_RS01950	COG0840	transmembrane signaling receptor activity
FE785_RS01955	COG1999	signal sequence binding
FE785_RS01960	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FE785_RS01965	COG0259	pyridoxamine-phosphate oxidase activity
FE785_RS01980	COG0840	transmembrane signaling receptor activity
FE785_RS01985	COG0840	transmembrane signaling receptor activity
FE785_RS02000	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FE785_RS02015	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FE785_RS02020	COG1360	Flagellar Motor Protein
FE785_RS02025	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FE785_RS02030	COG2890	protein-(glutamine-N5) methyltransferase activity
FE785_RS02035	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FE785_RS02040	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FE785_RS02055	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FE785_RS02060	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FE785_RS02065	COG0193	aminoacyl-tRNA hydrolase activity
FE785_RS02070	COG0012	GTP binding
FE785_RS02080	COG0582	viral genome integration into host DNA
FE785_RS02110	COG3706	GGDEF domain
FE785_RS02145	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FE785_RS02155	COG2226	methyltransferase
FE785_RS02165	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FE785_RS02170	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FE785_RS02190	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FE785_RS02200	COG1519	Transferase
FE785_RS02205	COG0517	IMP dehydrogenase activity
FE785_RS02205	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FE785_RS02215	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FE785_RS02215	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FE785_RS02220	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FE785_RS02225	COG0837	glucose binding
FE785_RS02230	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FE785_RS02245	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FE785_RS02250	COG0297	glycogen (starch) synthase activity
FE785_RS02255	COG0058	SHG alpha-glucan phosphorylase activity
FE785_RS02260	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FE785_RS02265	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FE785_RS02300	COG0438	transferase activity, transferring glycosyl groups
FE785_RS02335	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FE785_RS02340	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FE785_RS02365	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FE785_RS02395	COG2244	polysaccharide biosynthetic process
FE785_RS02400	COG1216	Glycosyl transferase, family 2
FE785_RS02400	COG0463	Glycosyl transferase, family 2
FE785_RS02410	COG0438	transferase activity, transferring glycosyl groups
FE785_RS02415	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FE785_RS02425	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FE785_RS02440	COG1793	dna ligase
FE785_RS02445	COG0436	Aminotransferase
FE785_RS02450	COG0556	nucleotide-excision repair
FE785_RS02465	COG2866	Carboxypeptidase
FE785_RS02485	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FE785_RS02490	COG0795	lipopolysaccharide-transporting ATPase activity
FE785_RS02495	COG0795	lipopolysaccharide-transporting ATPase activity
FE785_RS02515	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FE785_RS02535	COG0582	viral genome integration into host DNA
FE785_RS02545	COG2202	Pas domain
FE785_RS02545	COG2205	protein histidine kinase activity
FE785_RS02575	COG5001	Diguanylate cyclase
FE785_RS02575	COG3300	MHYT domain
FE785_RS02580	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FE785_RS02585	COG0343	queuine tRNA-ribosyltransferase activity
FE785_RS02590	COG1862	Preprotein translocase
FE785_RS02595	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FE785_RS02600	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FE785_RS02605	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FE785_RS02630	COG2239	Acts as a magnesium transporter
FE785_RS02640	COG1137	ATPase activity
FE785_RS02670	COG1127	ABC transporter
FE785_RS02675	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FE785_RS02680	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FE785_RS02695	COG1131	(ABC) transporter
FE785_RS02700	COG0842	Transport permease protein
FE785_RS02710	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FE785_RS02715	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FE785_RS02720	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FE785_RS02725	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FE785_RS02730	COG0723	plastoquinol--plastocyanin reductase activity
FE785_RS02735	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FE785_RS02740	COG2857	Cytochrome c1
FE785_RS02745	COG0069	glutamate synthase activity
FE785_RS02750	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FE785_RS02765	COG2198	Histidine kinase
FE785_RS02765	COG0784	Response regulator, receiver
FE785_RS02765	COG5002	protein histidine kinase activity
FE785_RS02770	COG0483	inositol monophosphate 1-phosphatase activity
FE785_RS02775	COG4536	flavin adenine dinucleotide binding
FE785_RS02785	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FE785_RS02790	COG0228	four-way junction DNA binding
FE785_RS02795	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FE785_RS02800	COG0336	Belongs to the RNA methyltransferase TrmD family
FE785_RS02805	COG0335	large ribosomal subunit rRNA binding
FE785_RS02815	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FE785_RS02820	COG4991	sh3 domain protein
FE785_RS02825	COG0525	valine-tRNA ligase activity
FE785_RS02830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FE785_RS02845	COG0004	ammonium transporteR
FE785_RS02850	COG0347	Belongs to the P(II) protein family
FE785_RS02860	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FE785_RS02865	COG0174	glutamine synthetase
FE785_RS02870	COG0573	inorganic phosphate transmembrane transporter activity
FE785_RS02875	COG0581	inorganic phosphate transmembrane transporter activity
FE785_RS02880	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FE785_RS02890	COG0745	RESPONSE REGULATOR receiver
FE785_RS02895	COG5002	protein histidine kinase activity
FE785_RS02925	COG0271	Belongs to the BolA IbaG family
FE785_RS02935	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FE785_RS02940	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FE785_RS02945	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FE785_RS02950	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FE785_RS02955	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FE785_RS02965	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FE785_RS02970	COG1187	pseudouridine synthase activity
FE785_RS02975	COG1278	Cold shock
FE785_RS02980	COG0385	Bile acid
FE785_RS02990	COG0784	Response regulator, receiver
FE785_RS02990	COG4191	Histidine kinase
FE785_RS02995	COG3022	response to hydroperoxide
FE785_RS03025	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FE785_RS03030	COG0321	lipoyl(octanoyl) transferase activity
FE785_RS03035	COG2921	Belongs to the UPF0250 family
FE785_RS03045	COG1686	Belongs to the peptidase S11 family
FE785_RS03050	COG0772	Belongs to the SEDS family
FE785_RS03055	COG0768	penicillin binding
FE785_RS03065	COG1792	Involved in formation and maintenance of cell shape
FE785_RS03070	COG1077	Cell shape determining protein MreB Mrl
FE785_RS03075	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FE785_RS03080	COG0154	amidase activity
FE785_RS03085	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FE785_RS03090	COG0501	Belongs to the peptidase M48B family
FE785_RS03100	COG1704	LemA family
FE785_RS03125	COG0811	peptide transport
FE785_RS03135	COG2015	COG2015, Alkyl sulfatase and related hydrolases
FE785_RS03140	COG0560	Phosphoserine phosphatase
FE785_RS03160	COG0516	GMP reductase activity
FE785_RS03160	COG0517	IMP dehydrogenase activity
FE785_RS03165	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FE785_RS03165	COG0519	Catalyzes the synthesis of GMP from XMP
FE785_RS03170	COG0590	tRNA wobble adenosine to inosine editing
FE785_RS03175	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
FE785_RS03180	COG2198	Histidine kinase
FE785_RS03180	COG0643	Histidine kinase
FE785_RS03190	COG0326	Molecular chaperone. Has ATPase activity
FE785_RS03195	COG0488	(ABC) transporter
FE785_RS03215	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FE785_RS03220	COG0545	Peptidyl-prolyl cis-trans isomerase
FE785_RS03235	COG3118	belongs to the thioredoxin family
FE785_RS03240	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FE785_RS03245	COG5001	Diguanylate cyclase
FE785_RS03245	COG5002	protein histidine kinase activity
FE785_RS03250	COG1546	Belongs to the CinA family
FE785_RS03255	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FE785_RS03260	COG2137	regulation of response to DNA damage stimulus
FE785_RS03265	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FE785_RS03290	COG3706	GGDEF domain
FE785_RS03295	COG1716	ATPase activity
FE785_RS03295	COG5001	Diguanylate cyclase
FE785_RS03315	COG0561	phosphatase activity
FE785_RS03320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FE785_RS03325	COG1321	iron dependent repressor
FE785_RS03325	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FE785_RS03330	COG1121	(ABC) transporter
FE785_RS03335	COG0803	Belongs to the bacterial solute-binding protein 9 family
FE785_RS03340	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FE785_RS03345	COG0602	queuosine metabolic process
FE785_RS03350	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FE785_RS03355	COG0066	3-isopropylmalate dehydratase activity
FE785_RS03360	COG0473	3-isopropylmalate dehydrogenase activity
FE785_RS03365	COG0739	heme binding
FE785_RS03375	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FE785_RS03380	COG0101	tRNA pseudouridine synthase activity
FE785_RS03385	COG0135	phosphoribosylanthranilate isomerase activity
FE785_RS03395	COG0159	tryptophan synthase activity
FE785_RS03400	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FE785_RS03405	COG0285	dihydrofolate synthase activity
FE785_RS03425	COG1534	Rna-binding protein
FE785_RS03430	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FE785_RS03435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FE785_RS03440	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FE785_RS03445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FE785_RS03450	COG0149	triose-phosphate isomerase activity
FE785_RS03465	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FE785_RS03470	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FE785_RS03475	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FE785_RS03480	COG0649	NAD binding
FE785_RS03495	COG1034	ATP synthesis coupled electron transport
FE785_RS03500	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FE785_RS03505	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FE785_RS03515	COG0713	ATP synthesis coupled electron transport
FE785_RS03530	COG1007	ATP synthesis coupled electron transport
FE785_RS03545	COG0582	viral genome integration into host DNA
FE785_RS03570	COG2161	toxin-antitoxin pair type II binding
FE785_RS03590	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FE785_RS03620	COG0784	Response regulator, receiver
FE785_RS03620	COG2205	protein histidine kinase activity
FE785_RS03620	COG5002	protein histidine kinase activity
FE785_RS03655	COG1192	Involved in chromosome partitioning
FE785_RS03665	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FE785_RS03685	COG2205	protein histidine kinase activity
FE785_RS03685	COG0784	Response regulator, receiver
FE785_RS03685	COG5002	protein histidine kinase activity
FE785_RS03700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FE785_RS03705	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FE785_RS03725	COG2203	Gaf domain
FE785_RS03725	COG2199	diguanylate cyclase activity
FE785_RS03730	COG0205	6-phosphofructokinase activity
FE785_RS03735	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FE785_RS03740	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FE785_RS03765	COG3101	peptidyl-lysine hydroxylation
FE785_RS03770	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FE785_RS03775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FE785_RS03780	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FE785_RS03795	COG1999	signal sequence binding
FE785_RS03800	COG4206	TonB-dependent receptor
FE785_RS03805	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FE785_RS03815	COG0717	Belongs to the dCTP deaminase family
FE785_RS03825	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FE785_RS03830	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FE785_RS03840	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FE785_RS03845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FE785_RS03860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FE785_RS03875	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FE785_RS03880	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FE785_RS03885	COG0840	transmembrane signaling receptor activity
FE785_RS03905	COG0442	prolyl-tRNA aminoacylation
FE785_RS03930	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FE785_RS03935	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FE785_RS03940	COG0802	atpase or kinase
FE785_RS03945	COG0860	N-Acetylmuramoyl-L-alanine amidase
FE785_RS03950	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FE785_RS03960	COG3079	Belongs to the UPF0149 family
FE785_RS03965	COG0006	proline dipeptidase activity
FE785_RS03970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FE785_RS03975	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FE785_RS03980	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FE785_RS03990	COG0545	Peptidyl-prolyl cis-trans isomerase
FE785_RS03995	COG0492	ferredoxin-NADP+ reductase activity
FE785_RS04000	COG1674	ftsk spoiiie
FE785_RS04005	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FE785_RS04010	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FE785_RS04015	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FE785_RS04020	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FE785_RS04025	COG0509	glycine decarboxylation via glycine cleavage system
FE785_RS04030	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FE785_RS04030	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FE785_RS04040	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FE785_RS04055	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FE785_RS04065	COG3706	GGDEF domain
FE785_RS04080	COG5002	protein histidine kinase activity
FE785_RS04080	COG2205	protein histidine kinase activity
FE785_RS04080	COG0784	Response regulator, receiver
FE785_RS04105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FE785_RS04110	COG1530	ribonuclease E activity
FE785_RS04120	COG0546	phosphoglycolate phosphatase activity
FE785_RS04125	COG0424	maF-like protein
FE785_RS04135	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FE785_RS04140	COG0416	fatty acid biosynthetic process
FE785_RS04145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FE785_RS04150	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FE785_RS04155	COG1028	Short-chain dehydrogenase reductase Sdr
FE785_RS04160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FE785_RS04165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FE785_RS04170	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FE785_RS04175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FE785_RS04180	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FE785_RS04185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FE785_RS04195	COG0084	hydrolase, TatD family'
FE785_RS04200	COG1132	(ABC) transporter
FE785_RS04205	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FE785_RS04240	COG0840	transmembrane signaling receptor activity
FE785_RS04240	COG0840	transmembrane signaling receptor activity
FE785_RS04250	COG2202	Pas domain
FE785_RS04250	COG2205	protein histidine kinase activity
FE785_RS04255	COG3437	response regulator, receiver
FE785_RS04260	COG5002	protein histidine kinase activity
FE785_RS04265	COG0745	RESPONSE REGULATOR receiver
FE785_RS04275	COG1902	pentaerythritol trinitrate reductase activity
FE785_RS04290	COG0300	oxidoreductase activity
FE785_RS04305	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FE785_RS04325	COG1366	Belongs to the anti-sigma-factor antagonist family
FE785_RS04360	COG0415	Belongs to the DNA photolyase family
FE785_RS04375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FE785_RS04405	COG0174	glutamine synthetase
FE785_RS04415	COG0837	glucose binding
FE785_RS04425	COG0439	Biotin carboxylase
FE785_RS04430	COG3665	Urea carboxylase-associated protein
FE785_RS04440	COG0864	Transcriptional regulator
FE785_RS04450	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FE785_RS04455	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FE785_RS04455	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FE785_RS04460	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FE785_RS04465	COG1090	epimerase
FE785_RS04470	COG2239	Acts as a magnesium transporter
FE785_RS04475	COG0189	ligase activity
FE785_RS04475	COG4067	protein conserved in archaea
FE785_RS04480	COG0189	ligase activity
FE785_RS04495	COG0667	Aldo Keto reductase
FE785_RS04500	COG1473	amidohydrolase
FE785_RS04505	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FE785_RS04510	COG0006	proline dipeptidase activity
FE785_RS04515	COG1012	belongs to the aldehyde dehydrogenase family
FE785_RS04520	COG0438	transferase activity, transferring glycosyl groups
FE785_RS04525	COG3100	YcgL domain-containing protein
FE785_RS04525	COG0561	phosphatase activity
FE785_RS04540	COG2223	nitrite transmembrane transporter activity
FE785_RS04550	COG3002	Belongs to the UPF0753 family
FE785_RS04560	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FE785_RS04580	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FE785_RS04590	COG2867	negative regulation of translational initiation
FE785_RS04610	COG0735	belongs to the Fur family
FE785_RS04615	COG0497	DNA recombination
FE785_RS04620	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FE785_RS04625	COG1420	regulation of RNA biosynthetic process
FE785_RS04630	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FE785_RS04635	COG0443	Heat shock 70 kDa protein
FE785_RS04640	COG0484	heat shock protein binding
FE785_RS04645	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FE785_RS04655	COG0791	NLP P60 protein
FE785_RS04660	COG0505	Belongs to the CarA family
FE785_RS04670	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FE785_RS04685	COG2833	Protein of unknown function (DUF455)
FE785_RS04695	COG1940	carbohydrate kinase activity
FE785_RS04715	COG0300	oxidoreductase activity
FE785_RS04720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FE785_RS04730	COG5002	protein histidine kinase activity
FE785_RS04730	COG0784	Response regulator, receiver
FE785_RS04735	COG2197	response regulator
FE785_RS04750	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FE785_RS04765	COG0835	chemotaxis
FE785_RS04770	COG0720	synthase
FE785_RS04775	COG0142	geranyltranstransferase activity
FE785_RS04780	COG0517	IMP dehydrogenase activity
FE785_RS04795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FE785_RS04800	COG0481	GTPase activity
FE785_RS04825	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FE785_RS04830	COG0736	holo-[acyl-carrier-protein] synthase activity
FE785_RS04865	COG1136	(ABC) transporter
FE785_RS04910	COG1047	Peptidyl-prolyl cis-trans
FE785_RS04920	COG0045	succinate-CoA ligase (ADP-forming) activity
FE785_RS04930	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FE785_RS04930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FE785_RS04940	COG0564	pseudouridine synthase activity
FE785_RS04985	COG1051	belongs to the nudix hydrolase family
FE785_RS04990	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FE785_RS04995	COG0508	dehydrogenase complex catalyzes the overall conversion of
FE785_RS05000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FE785_RS05015	COG3530	Putative quorum-sensing-regulated virulence factor
FE785_RS05040	COG1278	Cold shock
FE785_RS05060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FE785_RS05065	COG2203	Gaf domain
FE785_RS05065	COG2199	diguanylate cyclase activity
FE785_RS05075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FE785_RS05080	COG0840	transmembrane signaling receptor activity
FE785_RS05085	COG0513	Belongs to the DEAD box helicase family
FE785_RS05100	COG1846	Transcriptional regulator
FE785_RS05100	COG0456	acetyltransferase
FE785_RS05110	COG1671	Belongs to the UPF0178 family
FE785_RS05130	COG3384	dioxygenase
FE785_RS05140	COG2133	pyrroloquinoline quinone binding
FE785_RS05160	COG1720	tRNA m6t6A37 methyltransferase activity
FE785_RS05170	COG0604	alcohol dehydrogenase
FE785_RS05170	COG3321	synthase
FE785_RS05190	COG1741	Belongs to the pirin family
FE785_RS05195	COG2259	Doxx family
FE785_RS05200	COG0583	DNA-binding transcription factor activity
FE785_RS05210	COG0564	pseudouridine synthase activity
FE785_RS05215	COG2983	Belongs to the UPF0260 family
FE785_RS05220	COG1047	Peptidyl-prolyl cis-trans
FE785_RS05230	COG1981	membrane
FE785_RS05255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FE785_RS05260	COG1252	NADH dehydrogenase
FE785_RS05270	COG0574	Belongs to the PEP-utilizing enzyme family
FE785_RS05270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FE785_RS05280	COG0826	peptidase U32
FE785_RS05285	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FE785_RS05305	COG0544	peptidyl-prolyl cis-trans isomerase activity
FE785_RS05310	COG0740	serine-type endopeptidase activity
FE785_RS05315	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FE785_RS05320	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FE785_RS05355	COG0747	negative chemotaxis
FE785_RS05370	COG4172	Belongs to the ABC transporter superfamily
FE785_RS05380	COG1028	Short-chain dehydrogenase reductase Sdr
FE785_RS05390	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FE785_RS05400	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FE785_RS05405	COG0077	Prephenate dehydratase
FE785_RS05405	COG1605	Chorismate mutase
FE785_RS05410	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FE785_RS05415	COG0287	Prephenate dehydrogenase
FE785_RS05420	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FE785_RS05425	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FE785_RS05435	COG0776	regulation of translation
FE785_RS05445	COG0284	orotidine-5'-phosphate decarboxylase activity
FE785_RS05450	COG0360	Binds together with S18 to 16S ribosomal RNA
FE785_RS05455	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FE785_RS05465	COG0359	binds to the 23S rRNA
FE785_RS05475	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FE785_RS05480	COG0494	nUDIX hydrolase
FE785_RS05490	COG0534	Mate efflux family protein
FE785_RS05495	COG3012	SEC-C Motif Domain Protein
FE785_RS05510	COG0745	RESPONSE REGULATOR receiver
FE785_RS05520	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FE785_RS05530	COG1393	Belongs to the ArsC family
FE785_RS05540	COG1570	exodeoxyribonuclease VII activity
FE785_RS05545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FE785_RS05550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FE785_RS05575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FE785_RS05605	COG1187	pseudouridine synthase activity
FE785_RS05610	COG1994	Peptidase M50
FE785_RS05615	COG0009	L-threonylcarbamoyladenylate synthase
FE785_RS05620	COG0613	PHP domain protein
FE785_RS05625	COG2917	probably involved in intracellular septation
FE785_RS05630	COG2350	Protein conserved in bacteria
FE785_RS05635	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FE785_RS05655	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FE785_RS05660	COG3115	cell septum assembly
FE785_RS05665	COG1070	Carbohydrate kinase
FE785_RS05675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FE785_RS05710	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FE785_RS05715	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FE785_RS05730	COG0436	Aminotransferase
FE785_RS05750	COG1238	metal cluster binding
FE785_RS05755	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FE785_RS05765	COG2840	Smr protein MutS2
FE785_RS05770	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FE785_RS05775	COG0148	phosphopyruvate hydratase activity
FE785_RS05780	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FE785_RS05785	COG0504	CTP synthase activity
FE785_RS05790	COG0037	tRNA processing
FE785_RS05795	COG0825	malonyl-CoA metabolic process
FE785_RS05805	COG1944	ATP diphosphatase activity
FE785_RS05820	COG0589	response to stress
FE785_RS05825	COG1214	PFAM Peptidase M22, glycoprotease
FE785_RS05830	COG1199	ATP-dependent helicase activity
FE785_RS05835	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FE785_RS05840	COG0784	Response regulator, receiver
FE785_RS05840	COG0835	chemotaxis
FE785_RS05845	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FE785_RS05850	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FE785_RS05855	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FE785_RS05860	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FE785_RS05865	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FE785_RS05885	COG0575	Belongs to the CDS family
FE785_RS05895	COG0233	cytoplasmic translational termination
FE785_RS05900	COG0528	UMP kinase activity
FE785_RS05905	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FE785_RS05910	COG0052	Belongs to the universal ribosomal protein uS2 family
FE785_RS05915	COG0024	Methionine aminopeptidase
FE785_RS05920	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FE785_RS05925	COG0346	lactoylglutathione lyase activity
FE785_RS05930	COG2171	N-acyltransferase activity
FE785_RS05935	COG1393	Belongs to the ArsC family
FE785_RS05940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FE785_RS05950	COG0733	neurotransmitter:sodium symporter activity
FE785_RS05955	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FE785_RS05965	COG0668	transmembrane transport
FE785_RS05970	COG1472	Belongs to the glycosyl hydrolase 3 family
FE785_RS05980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FE785_RS05985	COG0601	transmembrane transport
FE785_RS06000	COG1538	Outer membrane efflux protein
FE785_RS06005	COG2954	triphosphatase activity
FE785_RS06020	COG0840	transmembrane signaling receptor activity
FE785_RS06025	COG0488	(ABC) transporter
FE785_RS06030	COG1136	(ABC) transporter
FE785_RS06035	COG4591	ABC-type transport system involved in lipoprotein release permease component
FE785_RS06045	COG0446	pyridine nucleotide-disulphide oxidoreductase
FE785_RS06050	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FE785_RS06060	COG0850	regulation of cytokinetic process
FE785_RS06070	COG2200	EAL domain
FE785_RS06070	COG2199	diguanylate cyclase activity
FE785_RS06080	COG4943	cyclic-guanylate-specific phosphodiesterase activity
FE785_RS06085	COG2203	Gaf domain
FE785_RS06085	COG3706	GGDEF domain
FE785_RS06085	COG4251	negative regulation of phosphorylation
FE785_RS06085	COG5001	Diguanylate cyclase
FE785_RS06090	COG0746	molybdenum cofactor guanylyltransferase activity
FE785_RS06095	COG0303	'Molybdopterin
FE785_RS06100	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FE785_RS06105	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FE785_RS06105	COG1648	precorrin-2 dehydrogenase activity
FE785_RS06110	COG0243	molybdopterin cofactor binding
FE785_RS06120	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FE785_RS06125	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FE785_RS06130	COG2223	nitrite transmembrane transporter activity
FE785_RS06135	COG0515	serine threonine protein kinase
FE785_RS06135	COG2815	serine threonine protein kinase
FE785_RS06140	COG0840	transmembrane signaling receptor activity
FE785_RS06145	COG1116	anion transmembrane transporter activity
FE785_RS06155	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FE785_RS06160	COG1116	anion transmembrane transporter activity
FE785_RS06160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FE785_RS06165	COG3707	response regulator
FE785_RS06170	COG0640	Transcriptional regulator
FE785_RS06180	COG2391	methyltransferase activity
FE785_RS06185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FE785_RS06185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FE785_RS06195	COG2202	Pas domain
FE785_RS06195	COG2205	protein histidine kinase activity
FE785_RS06200	COG3437	response regulator, receiver
FE785_RS06210	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FE785_RS06215	COG5001	Diguanylate cyclase
FE785_RS06215	COG3300	MHYT domain
FE785_RS06245	COG0582	viral genome integration into host DNA
FE785_RS06270	COG0322	excinuclease ABC activity
FE785_RS06275	COG0616	signal peptide processing
FE785_RS06285	COG1049	propionate catabolic process, 2-methylcitrate cycle
FE785_RS06295	COG2850	peptidyl-arginine hydroxylation
FE785_RS06305	COG2199	diguanylate cyclase activity
FE785_RS06315	COG1185	polyribonucleotide nucleotidyltransferase activity
FE785_RS06320	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FE785_RS06335	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FE785_RS06340	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FE785_RS06345	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FE785_RS06350	COG2251	uridine kinase activity
FE785_RS06350	COG0195	Participates in both transcription termination and antitermination
FE785_RS06355	COG0779	Required for maturation of 30S ribosomal subunits
FE785_RS06360	COG2176	DNA-directed DNA polymerase activity
FE785_RS06370	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FE785_RS06380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FE785_RS06410	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FE785_RS06425	COG1053	succinate dehydrogenase
FE785_RS06440	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FE785_RS06445	COG0542	response to heat
FE785_RS06450	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FE785_RS06460	COG2824	Alkylphosphonate utilization operon protein PhnA
FE785_RS06475	COG0217	transcriptional regulatory protein
FE785_RS06485	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
FE785_RS06490	COG0709	Synthesizes selenophosphate from selenide and ATP
FE785_RS06495	COG3341	Caulimovirus viroplasmin
FE785_RS06495	COG0328	RNA-DNA hybrid ribonuclease activity
FE785_RS06530	COG0482	sulfurtransferase activity
FE785_RS06535	COG2915	High frequency lysogenization protein hflD homolog
FE785_RS06545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FE785_RS06555	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FE785_RS06560	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
FE785_RS06570	COG0330	HflC and HflK could
FE785_RS06575	COG0330	HflC and HflK could
FE785_RS06580	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FE785_RS06585	COG1923	regulation of RNA biosynthetic process
FE785_RS06590	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FE785_RS06600	COG0489	protein tyrosine kinase activity
FE785_RS06610	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FE785_RS06610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FE785_RS06615	COG4657	Part of a membrane complex involved in electron transport
FE785_RS06620	COG2878	Part of a membrane complex involved in electron transport
FE785_RS06625	COG4656	Part of a membrane complex involved in electron transport
FE785_RS06630	COG4658	electron transport chain
FE785_RS06635	COG4659	FMN binding
FE785_RS06640	COG4660	Part of a membrane complex involved in electron transport
FE785_RS06645	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FE785_RS06655	COG0328	RNA-DNA hybrid ribonuclease activity
FE785_RS06665	COG2205	protein histidine kinase activity
FE785_RS06665	COG0784	Response regulator, receiver
FE785_RS06670	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FE785_RS06675	COG0513	Belongs to the DEAD box helicase family
FE785_RS06700	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FE785_RS06735	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FE785_RS06745	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FE785_RS06750	COG2835	tetraacyldisaccharide 4'-kinase activity
FE785_RS06755	COG1663	tetraacyldisaccharide 4'-kinase activity
FE785_RS06760	COG2333	competence protein COMEC
FE785_RS06760	COG0658	competence protein
FE785_RS06770	COG1067	ATP-dependent peptidase activity
FE785_RS06775	COG0004	ammonium transporteR
FE785_RS06795	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FE785_RS06815	COG0435	Glutathione S-transferase
FE785_RS06825	COG1643	Atp-dependent helicase
FE785_RS06835	COG1047	Peptidyl-prolyl cis-trans
FE785_RS06840	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FE785_RS06845	COG0328	RNA-DNA hybrid ribonuclease activity
FE785_RS06855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FE785_RS06860	COG0741	lytic transglycosylase activity
FE785_RS06860	COG1388	LysM domain
FE785_RS06865	COG0741	lytic transglycosylase activity
FE785_RS06870	COG0215	cysteine-tRNA ligase activity
FE785_RS06880	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FE785_RS06885	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FE785_RS06895	COG1301	dicarboxylic acid transport
FE785_RS06905	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FE785_RS06910	COG0137	argininosuccinate synthase activity
FE785_RS06915	COG0688	phosphatidylethanolamine metabolic process
FE785_RS06930	COG2204	response regulator
FE785_RS06935	COG3852	Histidine kinase
FE785_RS06955	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FE785_RS06980	COG2885	chlorophyll binding
FE785_RS06985	COG0823	Involved in the tonB-independent uptake of proteins
FE785_RS06995	COG0848	biopolymer transport protein
FE785_RS07000	COG0811	peptide transport
FE785_RS07005	COG2255	four-way junction helicase activity
FE785_RS07010	COG0632	four-way junction helicase activity
FE785_RS07015	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FE785_RS07020	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FE785_RS07025	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FE785_RS07035	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FE785_RS07045	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FE785_RS07050	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FE785_RS07055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FE785_RS07060	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FE785_RS07075	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FE785_RS07075	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FE785_RS07080	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FE785_RS07085	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FE785_RS07090	COG0488	(ABC) transporter
FE785_RS07130	COG0047	phosphoribosylformylglycinamidine synthase activity
FE785_RS07130	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FE785_RS07140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FE785_RS07145	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FE785_RS07150	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FE785_RS07155	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FE785_RS07170	COG2201	protein-glutamate methylesterase activity
FE785_RS07185	COG0835	chemotaxis
FE785_RS07190	COG0745	RESPONSE REGULATOR receiver
FE785_RS07205	COG0835	chemotaxis
FE785_RS07210	COG2198	Histidine kinase
FE785_RS07210	COG0643	Histidine kinase
FE785_RS07210	COG0784	Response regulator, receiver
FE785_RS07215	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
FE785_RS07240	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FE785_RS07245	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FE785_RS07285	COG1360	Flagellar Motor Protein
FE785_RS07290	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FE785_RS07320	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FE785_RS07330	COG1677	Flagellar hook-basal body complex protein FliE
FE785_RS07340	COG4191	Histidine kinase
FE785_RS07360	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FE785_RS07375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FE785_RS07380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FE785_RS07385	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FE785_RS07390	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FE785_RS07400	COG1083	cytidylyl-transferase
FE785_RS07405	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FE785_RS07430	COG0107	imidazoleglycerol-phosphate synthase activity
FE785_RS07445	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FE785_RS07450	COG2089	acid synthase
FE785_RS07460	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FE785_RS07465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FE785_RS07470	COG0741	lytic transglycosylase activity
FE785_RS07490	COG1706	bacterial-type flagellum-dependent cell motility
FE785_RS07495	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FE785_RS07500	COG4786	Flagellar basal body rod
FE785_RS07505	COG4786	Flagellar basal body rod
FE785_RS07510	COG1749	Flagellar hook protein flgE
FE785_RS07515	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FE785_RS07520	COG1558	bacterial-type flagellum-dependent cell motility
FE785_RS07525	COG1815	bacterial-type flagellum-dependent cell motility
FE785_RS07535	COG0784	Response regulator, receiver
FE785_RS07535	COG0835	chemotaxis
FE785_RS07545	COG2747	anti-sigma28 factor FlgM
FE785_RS07585	COG0308	aminopeptidase N
FE785_RS07590	COG2885	chlorophyll binding
FE785_RS07595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FE785_RS07600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FE785_RS07605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FE785_RS07610	COG0557	exoribonuclease II activity
FE785_RS07615	COG0741	lytic transglycosylase activity
FE785_RS07620	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FE785_RS07620	COG0301	tRNA thio-modification
FE785_RS07630	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FE785_RS07635	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FE785_RS07645	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FE785_RS07660	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FE785_RS07665	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FE785_RS07670	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FE785_RS07675	COG0617	tRNA 3'-terminal CCA addition
FE785_RS07695	COG0659	secondary active sulfate transmembrane transporter activity
FE785_RS07700	COG2199	diguanylate cyclase activity
FE785_RS07700	COG2203	Gaf domain
FE785_RS07705	COG3123	guanosine phosphorylase activity
FE785_RS07725	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FE785_RS07750	COG3338	carbonate dehydratase activity
FE785_RS07755	COG2890	protein-(glutamine-N5) methyltransferase activity
FE785_RS07760	COG0521	Mo-molybdopterin cofactor biosynthetic process
FE785_RS07765	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FE785_RS07770	COG0840	transmembrane signaling receptor activity
FE785_RS07780	COG1136	(ABC) transporter
FE785_RS07855	COG1538	Outer membrane efflux protein
FE785_RS07880	COG0776	regulation of translation
FE785_RS07885	COG0072	phenylalanine-tRNA ligase activity
FE785_RS07885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FE785_RS07890	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FE785_RS07895	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FE785_RS07900	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FE785_RS07905	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FE785_RS07910	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FE785_RS07920	COG4771	TonB-dependent receptor
FE785_RS07940	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FE785_RS07955	COG3706	GGDEF domain
FE785_RS07980	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FE785_RS07985	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FE785_RS07995	COG0028	Belongs to the TPP enzyme family
FE785_RS08000	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FE785_RS08010	COG2154	pterin-4-alpha-carbinolamine dehydratase
FE785_RS08015	COG1162	GTPase activity
FE785_RS08035	COG1160	GTP binding
FE785_RS08040	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FE785_RS08045	COG2976	Protein conserved in bacteria
FE785_RS08050	COG0124	histidyl-tRNA synthetase
FE785_RS08060	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FE785_RS08070	COG0316	Belongs to the HesB IscA family
FE785_RS08075	COG1959	2 iron, 2 sulfur cluster binding
FE785_RS08105	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FE785_RS08110	COG1183	phosphatidylcholine synthase activity
FE785_RS08115	COG2210	Belongs to the sulfur carrier protein TusA family
FE785_RS08125	COG4783	chaperone-mediated protein folding
FE785_RS08145	COG3258	Cytochrome c
FE785_RS08155	COG0129	dihydroxy-acid dehydratase activity
FE785_RS08165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FE785_RS08175	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FE785_RS08180	COG0367	asparagine synthase
FE785_RS08195	COG0237	dephospho-CoA kinase activity
FE785_RS08200	COG0494	nUDIX hydrolase
FE785_RS08205	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FE785_RS08210	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FE785_RS08215	COG0653	protein targeting
FE785_RS08225	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FE785_RS08235	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FE785_RS08240	COG1181	Belongs to the D-alanine--D-alanine ligase family
FE785_RS08245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FE785_RS08255	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FE785_RS08260	COG0719	Fe-S assembly protein
FE785_RS08265	COG0396	ATPase activity
FE785_RS08270	COG0719	Fe-S assembly protein
FE785_RS08280	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
FE785_RS08285	COG1121	(ABC) transporter
FE785_RS08290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FE785_RS08300	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FE785_RS08305	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FE785_RS08315	COG1028	Short-chain dehydrogenase reductase Sdr
FE785_RS08320	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FE785_RS08325	COG0772	Belongs to the SEDS family
FE785_RS08330	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FE785_RS08335	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FE785_RS08340	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FE785_RS08345	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FE785_RS08350	COG0768	penicillin binding
FE785_RS08360	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FE785_RS08365	COG0275	rRNA processing
FE785_RS08370	COG2001	Belongs to the MraZ family
FE785_RS08390	COG0742	ribosomal rna small subunit methyltransferase
FE785_RS08395	COG0745	RESPONSE REGULATOR receiver
FE785_RS08400	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FE785_RS08410	COG0792	nuclease activity
FE785_RS08425	COG1074	ATP-dependent DNA helicase activity
FE785_RS08440	COG0564	pseudouridine synthase activity
FE785_RS08450	COG2176	DNA-directed DNA polymerase activity
FE785_RS08465	COG2860	membrane
FE785_RS08485	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FE785_RS08495	COG1304	FMN binding
FE785_RS08500	COG3425	synthase
FE785_RS08505	COG0083	homoserine kinase activity
FE785_RS08520	COG2969	positive regulation of protein catabolic process
FE785_RS08525	COG0625	glutathione transferase activity
FE785_RS08530	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FE785_RS08535	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FE785_RS08540	COG1509	lysine 2,3-aminomutase activity
FE785_RS08555	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FE785_RS08585	COG0463	Glycosyl transferase, family 2
FE785_RS08620	COG1459	type II secretion system
FE785_RS08625	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FE785_RS08640	COG3267	Type II secretory pathway component ExeA
FE785_RS08640	COG3409	Peptidoglycan-binding domain 1 protein
FE785_RS08680	COG0424	maF-like protein
FE785_RS08690	COG0277	FAD linked oxidase domain protein
FE785_RS08715	COG0859	PFAM glycosyl transferase family 9
FE785_RS08720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FE785_RS08730	COG1132	(ABC) transporter
FE785_RS08735	COG1560	Kdo2-lipid A biosynthetic process
FE785_RS08750	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FE785_RS08755	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FE785_RS08760	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FE785_RS08770	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FE785_RS08845	COG2945	thiolester hydrolase activity
FE785_RS08850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FE785_RS08855	COG3439	Domain of unknown function DUF302
FE785_RS08885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FE785_RS08905	COG4232	protein-disulfide reductase activity
FE785_RS08910	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FE785_RS08915	COG0511	ligase activity, forming carbon-carbon bonds
FE785_RS08920	COG0439	Biotin carboxylase
FE785_RS08925	COG2264	protein methyltransferase activity
FE785_RS08930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FE785_RS08935	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FE785_RS08940	COG0138	bifunctional purine biosynthesis protein purh
FE785_RS08945	COG0151	Belongs to the GarS family
FE785_RS08955	COG0542	response to heat
FE785_RS08970	COG3706	GGDEF domain
FE785_RS08975	COG0116	Belongs to the methyltransferase superfamily
FE785_RS08975	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FE785_RS08980	COG2951	lytic endotransglycosylase activity
FE785_RS08995	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FE785_RS09010	COG2022	thiamine diphosphate biosynthetic process
FE785_RS09020	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FE785_RS09025	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FE785_RS09030	COG0196	riboflavin kinase activity
FE785_RS09040	COG0028	Belongs to the TPP enzyme family
FE785_RS09045	COG2814	Major facilitator Superfamily
FE785_RS09050	COG0268	Binds directly to 16S ribosomal RNA
FE785_RS09055	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FE785_RS09060	COG0799	negative regulation of ribosome biogenesis
FE785_RS09065	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FE785_RS09070	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FE785_RS09085	COG0495	leucyl-tRNA aminoacylation
FE785_RS09095	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FE785_RS09100	COG4535	Mg2 and Co2 transporter CorC
FE785_RS09105	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FE785_RS09110	COG1702	phosphate starvation-inducible protein PhoH
FE785_RS09115	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FE785_RS09140	COG2165	general secretion pathway protein
FE785_RS09180	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FE785_RS09185	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FE785_RS09215	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FE785_RS09220	COG1218	3'(2'),5'-bisphosphate nucleotidase
FE785_RS09225	COG0494	nUDIX hydrolase
FE785_RS09230	COG1011	Hydrolase
FE785_RS09235	COG0500	methyltransferase
FE785_RS09245	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FE785_RS09250	COG0488	(ABC) transporter
FE785_RS09255	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FE785_RS09260	COG0840	transmembrane signaling receptor activity
FE785_RS09270	COG1595	DNA-templated transcription, initiation
FE785_RS09275	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FE785_RS09280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FE785_RS09285	COG1295	ribonuclease BN
FE785_RS09300	COG3220	belongs to the UPF0276 family
FE785_RS09310	COG0693	protein deglycase activity
FE785_RS09315	COG0793	Belongs to the peptidase S41A family
FE785_RS09320	COG0640	Transcriptional regulator
FE785_RS09345	COG1610	YqeY-like protein
FE785_RS09350	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FE785_RS09355	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FE785_RS09360	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FE785_RS09385	COG1968	undecaprenyl-diphosphatase activity
FE785_RS09390	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FE785_RS09390	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FE785_RS09400	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FE785_RS09410	COG5002	protein histidine kinase activity
FE785_RS09410	COG5001	Diguanylate cyclase
FE785_RS09410	COG3447	MASE1 domain protein
FE785_RS09415	COG4251	negative regulation of phosphorylation
FE785_RS09415	COG5001	Diguanylate cyclase
FE785_RS09415	COG3706	GGDEF domain
FE785_RS09415	COG2203	Gaf domain
FE785_RS09420	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FE785_RS09425	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FE785_RS09430	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FE785_RS09450	COG1678	Uncharacterized ACR, COG1678
FE785_RS09455	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FE785_RS09460	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FE785_RS09465	COG0540	Belongs to the ATCase OTCase family
FE785_RS09510	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FE785_RS09515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FE785_RS09515	COG2813	Specifically methylates the guanine in position
FE785_RS09520	COG5001	Diguanylate cyclase
FE785_RS09520	COG3300	MHYT domain
FE785_RS09550	COG0400	carboxylic ester hydrolase activity
FE785_RS09560	COG0019	diaminopimelate decarboxylase activity
FE785_RS09570	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FE785_RS09575	COG0509	glycine decarboxylation via glycine cleavage system
FE785_RS09585	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FE785_RS09600	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FE785_RS09610	COG1028	Short-chain dehydrogenase reductase Sdr
FE785_RS09615	COG0579	oxidoreductase
FE785_RS09620	COG0523	cobalamin synthesis protein
FE785_RS09625	COG1469	GTP cyclohydrolase I activity
FE785_RS09635	COG0628	permease
FE785_RS09640	COG1611	Belongs to the LOG family
FE785_RS09645	COG0513	Belongs to the DEAD box helicase family
FE785_RS09655	COG1012	belongs to the aldehyde dehydrogenase family
FE785_RS09660	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FE785_RS09665	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FE785_RS09680	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FE785_RS09695	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FE785_RS09705	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FE785_RS09710	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FE785_RS09730	COG0583	DNA-binding transcription factor activity
FE785_RS09750	COG3264	Mechanosensitive ion channel
FE785_RS09750	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FE785_RS09755	COG0668	transmembrane transport
FE785_RS09760	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FE785_RS09765	COG1666	GTP binding
FE785_RS09770	COG0436	Aminotransferase
FE785_RS09780	COG0756	dUTP diphosphatase activity
FE785_RS09785	COG1115	amino acid carrier protein
FE785_RS09790	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FE785_RS09800	COG2003	Belongs to the UPF0758 family
FE785_RS09805	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FE785_RS09810	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FE785_RS09820	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FE785_RS09825	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FE785_RS09830	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FE785_RS09860	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FE785_RS09865	COG0742	ribosomal rna small subunit methyltransferase
FE785_RS09870	COG2996	Protein conserved in bacteria
FE785_RS09880	COG0612	Peptidase, M16
FE785_RS09885	COG0612	Peptidase, M16
FE785_RS09890	COG0552	protein localization to endoplasmic reticulum
FE785_RS09910	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FE785_RS09920	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FE785_RS09950	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FE785_RS09955	COG0167	dihydroorotate dehydrogenase activity
FE785_RS09960	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FE785_RS09965	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FE785_RS09970	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FE785_RS09975	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FE785_RS09985	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FE785_RS09990	COG0067	glutamate synthase
FE785_RS09990	COG0069	glutamate synthase activity
FE785_RS09990	COG0070	glutamate synthase
FE785_RS09995	COG0493	'glutamate synthase
FE785_RS10005	COG2095	MarC family integral membrane protein
FE785_RS10040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FE785_RS10060	COG3706	GGDEF domain
FE785_RS10065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FE785_RS10070	COG2199	diguanylate cyclase activity
FE785_RS10070	COG2203	Gaf domain
FE785_RS10075	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FE785_RS10090	COG4771	TonB-dependent receptor
FE785_RS10100	COG0033	Phosphoglucomutase
FE785_RS10110	COG0390	transport system, permease component
FE785_RS10115	COG4619	ABC transporter
FE785_RS10120	COG0210	DNA helicase
FE785_RS10130	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FE785_RS10135	COG0254	rRNA binding
FE785_RS10145	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FE785_RS10150	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FE785_RS10155	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
FE785_RS10165	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FE785_RS10175	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FE785_RS10190	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FE785_RS10195	COG1561	YicC-like family, N-terminal region
FE785_RS10210	COG3001	Fructosamine kinase
FE785_RS10215	COG0563	adenylate kinase activity
FE785_RS10225	COG4651	solute:proton antiporter activity
FE785_RS10225	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FE785_RS10250	COG1484	DNA-dependent DNA replication
FE785_RS10260	COG2217	Heavy metal translocating P-type atpase
FE785_RS10270	COG2132	Multicopper oxidase
FE785_RS10310	COG0511	ligase activity, forming carbon-carbon bonds
FE785_RS10325	COG0640	Transcriptional regulator
FE785_RS10335	COG2391	methyltransferase activity
FE785_RS10340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FE785_RS10340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FE785_RS10345	COG0477	Major facilitator Superfamily
FE785_RS10390	COG0582	viral genome integration into host DNA
FE785_RS10415	COG0363	glucosamine-6-phosphate deaminase activity
FE785_RS10435	COG1215	transferase activity, transferring glycosyl groups
FE785_RS10440	COG3769	mannosylglycerate metabolic process
FE785_RS10445	COG1854	S-ribosylhomocysteine lyase activity
FE785_RS10450	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FE785_RS10455	COG3647	Membrane
FE785_RS10465	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FE785_RS10480	COG2770	Histidine kinase
FE785_RS10480	COG3437	response regulator, receiver
FE785_RS10485	COG0676	glucose-6-phosphate 1-epimerase activity
FE785_RS10490	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FE785_RS10495	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FE785_RS10500	COG0194	GDP metabolic process
FE785_RS10505	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FE785_RS10510	COG1454	alcohol dehydrogenase
FE785_RS10515	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FE785_RS10525	COG1758	RNA polymerase activity
FE785_RS10545	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FE785_RS10550	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FE785_RS10555	COG3161	chorismate lyase activity
FE785_RS10575	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FE785_RS10590	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FE785_RS10595	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FE785_RS10600	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FE785_RS10605	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FE785_RS10610	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FE785_RS10615	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FE785_RS10620	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FE785_RS10625	COG0356	it plays a direct role in the translocation of protons across the membrane
FE785_RS10645	COG1192	Involved in chromosome partitioning
FE785_RS10650	COG0357	Ribosomal RNA small subunit methyltransferase G
FE785_RS10655	COG0445	tRNA wobble uridine modification
FE785_RS10670	COG4175	Glycine betaine
FE785_RS10675	COG4176	ABC-type proline glycine betaine transport system permease component
FE785_RS10680	COG2113	Glycine betaine
FE785_RS10695	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FE785_RS10695	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FE785_RS10740	COG1739	Uncharacterized protein family UPF0029
FE785_RS10750	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FE785_RS10760	COG0706	membrane insertase activity
FE785_RS10765	COG0594	ribonuclease P activity
FE785_RS10770	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FE785_RS10780	COG5001	Diguanylate cyclase
FE785_RS10780	COG5002	protein histidine kinase activity
FE785_RS10785	COG0730	response to heat