locus-tag	class	description
EP181_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EP181_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EP181_RS00025	COG0500	methyltransferase
EP181_RS00030	COG0714	Associated with various cellular activities
EP181_RS00050	COG2304	oxidoreductase activity
EP181_RS00065	COG0840	transmembrane signaling receptor activity
EP181_RS00070	COG1858	cytochrome C peroxidase
EP181_RS00085	COG0339	signal peptide processing
EP181_RS00090	COG2199	diguanylate cyclase activity
EP181_RS00100	COG1283	sodium-dependent phosphate transmembrane transporter activity
EP181_RS00110	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EP181_RS00115	COG3620	sequence-specific DNA binding
EP181_RS00115	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EP181_RS00115	COG0617	tRNA 3'-terminal CCA addition
EP181_RS00120	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EP181_RS00125	COG1522	sequence-specific DNA binding
EP181_RS00130	COG2205	protein histidine kinase activity
EP181_RS00130	COG0784	Response regulator, receiver
EP181_RS00160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EP181_RS00170	COG0028	Belongs to the TPP enzyme family
EP181_RS00175	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EP181_RS00180	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EP181_RS00185	COG1333	cytochrome c biogenesis protein
EP181_RS00190	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EP181_RS00195	COG0784	Response regulator, receiver
EP181_RS00195	COG2205	protein histidine kinase activity
EP181_RS00210	COG3706	GGDEF domain
EP181_RS00210	COG4251	negative regulation of phosphorylation
EP181_RS00210	COG5001	Diguanylate cyclase
EP181_RS00210	COG2203	Gaf domain
EP181_RS00225	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EP181_RS00225	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EP181_RS00230	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EP181_RS00270	COG0009	L-threonylcarbamoyladenylate synthase
EP181_RS00285	COG0408	coproporphyrinogen oxidase activity
EP181_RS00300	COG3954	Phosphoribulokinase
EP181_RS00305	COG0187	DNA topoisomerase II activity
EP181_RS00310	COG0071	Belongs to the small heat shock protein (HSP20) family
EP181_RS00320	COG2226	methyltransferase
EP181_RS00335	COG1320	monovalent cation:proton antiporter activity
EP181_RS00340	COG2212	antiporter activity
EP181_RS00355	COG1006	Multisubunit Na H antiporter MnhC subunit
EP181_RS00360	COG2111	Na H antiporter
EP181_RS00360	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EP181_RS00365	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EP181_RS00405	COG1518	maintenance of DNA repeat elements
EP181_RS00430	COG2801	Transposase and inactivated derivatives
EP181_RS00435	COG0840	transmembrane signaling receptor activity
EP181_RS00445	COG0714	Associated with various cellular activities
EP181_RS00465	COG2304	oxidoreductase activity
EP181_RS00480	COG3118	belongs to the thioredoxin family
EP181_RS00500	COG0515	serine threonine protein kinase
EP181_RS00500	COG3266	domain, Protein
EP181_RS00510	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EP181_RS00515	COG3706	GGDEF domain
EP181_RS00520	COG1187	pseudouridine synthase activity
EP181_RS00525	COG0165	Argininosuccinate lyase
EP181_RS00535	COG0181	hydroxymethylbilane synthase activity
EP181_RS00565	COG0543	2 iron, 2 sulfur cluster binding
EP181_RS00565	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EP181_RS00575	COG0788	formyltetrahydrofolate deformylase activity
EP181_RS00600	COG1444	tRNA N-acetyltransferase activity
EP181_RS00605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EP181_RS00605	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EP181_RS00615	COG0351	phosphomethylpyrimidine kinase
EP181_RS00620	COG0784	Response regulator, receiver
EP181_RS00620	COG2198	Histidine kinase
EP181_RS00620	COG2205	protein histidine kinase activity
EP181_RS00625	COG1058	Belongs to the CinA family
EP181_RS00625	COG1546	Belongs to the CinA family
EP181_RS00630	COG2081	HI0933 family
EP181_RS00640	COG0678	peroxiredoxin activity
EP181_RS00640	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EP181_RS00655	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EP181_RS00660	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EP181_RS00685	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EP181_RS00690	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EP181_RS00695	COG0314	molybdopterin synthase activity
EP181_RS00705	COG0315	cyclic pyranopterin monophosphate synthase activity
EP181_RS00710	COG2827	Endonuclease containing a URI domain
EP181_RS00740	COG2353	YceI-like domain
EP181_RS00760	COG1999	signal sequence binding
EP181_RS00765	COG0840	transmembrane signaling receptor activity
EP181_RS00775	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EP181_RS00780	COG2226	methyltransferase
EP181_RS00785	COG0596	Alpha beta hydrolase
EP181_RS00795	COG0156	8-amino-7-oxononanoate synthase activity
EP181_RS00800	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EP181_RS00815	COG2801	Transposase and inactivated derivatives
EP181_RS00840	COG1331	Highly conserved protein containing a thioredoxin domain
EP181_RS00850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EP181_RS00855	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EP181_RS00860	COG0537	adenosine 5'-monophosphoramidase activity
EP181_RS00865	COG0140	phosphoribosyl-ATP diphosphatase activity
EP181_RS00870	COG0107	imidazoleglycerol-phosphate synthase activity
EP181_RS00875	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EP181_RS00880	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EP181_RS00890	COG3278	Belongs to the heme-copper respiratory oxidase family
EP181_RS00910	COG0348	domain, Protein
EP181_RS00920	COG2217	Heavy metal translocating P-type atpase
EP181_RS00960	COG1217	gtp-binding protein TYPA
EP181_RS00970	COG2391	methyltransferase activity
EP181_RS00990	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EP181_RS00995	COG0730	response to heat
EP181_RS01005	COG0037	tRNA processing
EP181_RS01025	COG0569	domain protein
EP181_RS01030	COG2204	response regulator
EP181_RS01050	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EP181_RS01055	COG0242	peptide deformylase activity
EP181_RS01060	COG0758	DNA mediated transformation
EP181_RS01070	COG1754	DNA topoisomerase type I activity
EP181_RS01070	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EP181_RS01075	COG0018	arginyl-trna synthetase
EP181_RS01090	COG2960	long-chain fatty acid transporting porin activity
EP181_RS01095	COG0606	chelatase, subunit chli
EP181_RS01105	COG0840	transmembrane signaling receptor activity
EP181_RS01110	COG1538	Outer membrane efflux protein
EP181_RS01115	COG2197	response regulator
EP181_RS01140	COG1454	alcohol dehydrogenase
EP181_RS01145	COG0210	DNA helicase
EP181_RS01150	COG2813	Specifically methylates the guanine in position
EP181_RS01170	COG0840	transmembrane signaling receptor activity
EP181_RS01185	COG0585	pseudouridine synthase activity
EP181_RS01195	COG0784	Response regulator, receiver
EP181_RS01195	COG2205	protein histidine kinase activity
EP181_RS01195	COG5002	protein histidine kinase activity
EP181_RS01200	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EP181_RS01235	COG0840	transmembrane signaling receptor activity
EP181_RS01260	COG1929	Belongs to the glycerate kinase type-1 family
EP181_RS01270	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EP181_RS01275	COG3100	YcgL domain-containing protein
EP181_RS01285	COG0617	tRNA 3'-terminal CCA addition
EP181_RS01305	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EP181_RS01310	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EP181_RS01315	COG0126	phosphoglycerate kinase activity
EP181_RS01335	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EP181_RS01340	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EP181_RS01350	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EP181_RS01355	COG0546	phosphoglycolate phosphatase activity
EP181_RS01370	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EP181_RS01375	COG0134	indole-3-glycerol-phosphate synthase activity
EP181_RS01380	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EP181_RS01385	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EP181_RS01395	COG1765	OsmC-like protein
EP181_RS01400	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EP181_RS01400	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EP181_RS01405	COG0564	pseudouridine synthase activity
EP181_RS01425	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EP181_RS01435	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EP181_RS01445	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EP181_RS01450	COG0081	regulation of translation
EP181_RS01455	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EP181_RS01460	COG0222	ribosome binding
EP181_RS01465	COG0085	RNA polymerase activity
EP181_RS01470	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EP181_RS01475	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EP181_RS01480	COG0049	tRNA binding
EP181_RS01490	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EP181_RS01495	COG0051	transcription antitermination factor activity, RNA binding
EP181_RS01500	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EP181_RS01510	COG0089	rRNA binding
EP181_RS01515	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EP181_RS01520	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EP181_RS01525	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EP181_RS01530	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EP181_RS01535	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EP181_RS01545	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EP181_RS01550	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EP181_RS01555	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EP181_RS01560	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EP181_RS01565	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EP181_RS01570	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EP181_RS01575	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EP181_RS01585	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EP181_RS01590	COG1841	ribosomal large subunit assembly
EP181_RS01600	COG0201	protein transport
EP181_RS01605	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EP181_RS01610	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EP181_RS01615	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EP181_RS01620	COG0202	RNA polymerase activity
EP181_RS01625	COG0203	ribosomal protein L17
EP181_RS01630	COG0084	hydrolase, TatD family'
EP181_RS01635	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EP181_RS01645	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EP181_RS01655	COG2814	Major facilitator Superfamily
EP181_RS01660	COG0629	single-stranded DNA binding
EP181_RS01700	COG0142	geranyltranstransferase activity
EP181_RS01705	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EP181_RS01710	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EP181_RS01715	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EP181_RS01720	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EP181_RS01725	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EP181_RS01730	COG0459	protein refolding
EP181_RS01735	COG1917	Cupin 2, conserved barrel domain protein
EP181_RS01740	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EP181_RS01750	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EP181_RS01775	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EP181_RS01780	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EP181_RS01785	COG0316	Belongs to the HesB IscA family
EP181_RS01795	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EP181_RS01800	COG0739	heme binding
EP181_RS01805	COG0425	Belongs to the sulfur carrier protein TusA family
EP181_RS01805	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EP181_RS01815	COG0751	glycine-tRNA ligase activity
EP181_RS01820	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EP181_RS01840	COG1360	Flagellar Motor Protein
EP181_RS01845	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EP181_RS01860	COG0840	transmembrane signaling receptor activity
EP181_RS01865	COG0840	transmembrane signaling receptor activity
EP181_RS01880	COG0745	RESPONSE REGULATOR receiver
EP181_RS01895	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EP181_RS01910	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EP181_RS01915	COG1360	Flagellar Motor Protein
EP181_RS01920	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EP181_RS01925	COG2890	protein-(glutamine-N5) methyltransferase activity
EP181_RS01930	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EP181_RS01950	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EP181_RS01955	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EP181_RS01960	COG0193	aminoacyl-tRNA hydrolase activity
EP181_RS01965	COG0012	GTP binding
EP181_RS01980	COG0583	DNA-binding transcription factor activity
EP181_RS02025	COG0415	Belongs to the DNA photolyase family
EP181_RS02035	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EP181_RS02065	COG0415	Belongs to the DNA photolyase family
EP181_RS02100	COG2951	lytic endotransglycosylase activity
EP181_RS02115	COG2199	diguanylate cyclase activity
EP181_RS02135	COG0463	Glycosyl transferase, family 2
EP181_RS02155	COG4221	oxidoreductase activity
EP181_RS02160	COG2337	Toxic component of a toxin-antitoxin (TA) module
EP181_RS02170	COG0277	FAD linked oxidase domain protein
EP181_RS02180	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EP181_RS02200	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EP181_RS02205	COG0625	glutathione transferase activity
EP181_RS02210	COG2969	positive regulation of protein catabolic process
EP181_RS02225	COG0083	homoserine kinase activity
EP181_RS02230	COG3425	synthase
EP181_RS02235	COG1304	FMN binding
EP181_RS02245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EP181_RS02255	COG1704	LemA family
EP181_RS02260	COG0501	Belongs to the peptidase M48B family
EP181_RS02265	COG1275	C4-dicarboxylate transporter malic acid transport protein
EP181_RS02275	COG2176	DNA-directed DNA polymerase activity
EP181_RS02285	COG0564	pseudouridine synthase activity
EP181_RS02295	COG0501	Belongs to the peptidase M48B family
EP181_RS02300	COG0792	nuclease activity
EP181_RS02315	COG1741	Belongs to the pirin family
EP181_RS02320	COG0583	DNA-binding transcription factor activity
EP181_RS02325	COG0745	RESPONSE REGULATOR receiver
EP181_RS02330	COG0742	ribosomal rna small subunit methyltransferase
EP181_RS02350	COG2001	Belongs to the MraZ family
EP181_RS02360	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EP181_RS02375	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EP181_RS02380	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EP181_RS02390	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EP181_RS02400	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EP181_RS02410	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EP181_RS02415	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EP181_RS02425	COG0840	transmembrane signaling receptor activity
EP181_RS02430	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EP181_RS02440	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
EP181_RS02450	COG0719	Fe-S assembly protein
EP181_RS02455	COG0396	ATPase activity
EP181_RS02460	COG0719	Fe-S assembly protein
EP181_RS02465	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EP181_RS02475	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EP181_RS02480	COG1181	Belongs to the D-alanine--D-alanine ligase family
EP181_RS02495	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EP181_RS02505	COG0653	protein targeting
EP181_RS02515	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EP181_RS02520	COG0352	thiamine-phosphate diphosphorylase activity
EP181_RS02525	COG0237	dephospho-CoA kinase activity
EP181_RS02540	COG0367	asparagine synthase
EP181_RS02545	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EP181_RS02550	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EP181_RS02560	COG0129	dihydroxy-acid dehydratase activity
EP181_RS02570	COG3258	Cytochrome c
EP181_RS02590	COG4783	chaperone-mediated protein folding
EP181_RS02595	COG2210	Belongs to the sulfur carrier protein TusA family
EP181_RS02600	COG1183	phosphatidylcholine synthase activity
EP181_RS02605	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EP181_RS02615	COG0456	acetyltransferase
EP181_RS02635	COG1959	2 iron, 2 sulfur cluster binding
EP181_RS02640	COG0316	Belongs to the HesB IscA family
EP181_RS02645	COG0105	UTP biosynthetic process
EP181_RS02650	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EP181_RS02660	COG0124	histidyl-tRNA synthetase
EP181_RS02670	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EP181_RS02675	COG1160	GTP binding
EP181_RS02680	COG0277	FAD linked oxidase domain protein
EP181_RS02695	COG1162	GTPase activity
EP181_RS02700	COG2154	pterin-4-alpha-carbinolamine dehydratase
EP181_RS02705	COG0501	Belongs to the peptidase M48B family
EP181_RS02710	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EP181_RS02715	COG0028	Belongs to the TPP enzyme family
EP181_RS02725	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EP181_RS02740	COG0446	pyridine nucleotide-disulphide oxidoreductase
EP181_RS02760	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EP181_RS02795	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EP181_RS02800	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EP181_RS02805	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EP181_RS02810	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EP181_RS02815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EP181_RS02815	COG0072	phenylalanine-tRNA ligase activity
EP181_RS02820	COG0776	regulation of translation
EP181_RS02845	COG1538	Outer membrane efflux protein
EP181_RS02860	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EP181_RS02865	COG0545	Peptidyl-prolyl cis-trans isomerase
EP181_RS02870	COG0492	ferredoxin-NADP+ reductase activity
EP181_RS02875	COG1674	ftsk spoiiie
EP181_RS02880	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EP181_RS02885	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EP181_RS02890	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EP181_RS02895	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EP181_RS02900	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EP181_RS02930	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EP181_RS02950	COG0546	phosphoglycolate phosphatase activity
EP181_RS02955	COG0424	maF-like protein
EP181_RS02965	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EP181_RS02970	COG0416	fatty acid biosynthetic process
EP181_RS02975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EP181_RS02980	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EP181_RS02985	COG1028	Short-chain dehydrogenase reductase Sdr
EP181_RS02990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EP181_RS02995	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EP181_RS03000	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EP181_RS03005	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EP181_RS03010	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EP181_RS03020	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EP181_RS03025	COG0084	hydrolase, TatD family'
EP181_RS03030	COG1132	(ABC) transporter
EP181_RS03035	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EP181_RS03040	COG0154	amidase activity
EP181_RS03045	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EP181_RS03060	COG1074	ATP-dependent DNA helicase activity
EP181_RS03100	COG2166	iron-sulfur cluster assembly
EP181_RS03115	COG0848	biopolymer transport protein
EP181_RS03120	COG0811	peptide transport
EP181_RS03125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EP181_RS03130	COG0560	Phosphoserine phosphatase
EP181_RS03150	COG0516	GMP reductase activity
EP181_RS03150	COG0517	IMP dehydrogenase activity
EP181_RS03155	COG0519	Catalyzes the synthesis of GMP from XMP
EP181_RS03155	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EP181_RS03165	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
EP181_RS03170	COG2198	Histidine kinase
EP181_RS03170	COG0643	Histidine kinase
EP181_RS03180	COG0326	Molecular chaperone. Has ATPase activity
EP181_RS03185	COG0488	(ABC) transporter
EP181_RS03215	COG4942	peptidase
EP181_RS03230	COG0446	pyridine nucleotide-disulphide oxidoreductase
EP181_RS03300	COG3118	belongs to the thioredoxin family
EP181_RS03305	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EP181_RS03310	COG1546	Belongs to the CinA family
EP181_RS03315	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EP181_RS03325	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EP181_RS03355	COG1715	Restriction endonuclease
EP181_RS03360	COG2801	Transposase and inactivated derivatives
EP181_RS03385	COG1902	pentaerythritol trinitrate reductase activity
EP181_RS03390	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EP181_RS03400	COG0513	Belongs to the DEAD box helicase family
EP181_RS03405	COG0180	Tryptophanyl-tRNA synthetase
EP181_RS03415	COG0617	tRNA 3'-terminal CCA addition
EP181_RS03420	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EP181_RS03425	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EP181_RS03430	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EP181_RS03435	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EP181_RS03445	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EP181_RS03450	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EP181_RS03470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EP181_RS03480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EP181_RS03485	COG2885	chlorophyll binding
EP181_RS03545	COG0784	Response regulator, receiver
EP181_RS03545	COG0835	chemotaxis
EP181_RS03555	COG1815	bacterial-type flagellum-dependent cell motility
EP181_RS03565	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EP181_RS03570	COG1749	Flagellar hook protein flgE
EP181_RS03575	COG4787	bacterial-type flagellum-dependent cell motility
EP181_RS03580	COG4786	Flagellar basal body rod
EP181_RS03585	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EP181_RS03590	COG1706	bacterial-type flagellum-dependent cell motility
EP181_RS03605	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EP181_RS03610	COG0741	lytic transglycosylase activity
EP181_RS03620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EP181_RS03625	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EP181_RS03645	COG4804	nuclease activity
EP181_RS03655	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EP181_RS03670	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EP181_RS03675	COG1083	cytidylyl-transferase
EP181_RS03695	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EP181_RS03700	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EP181_RS03715	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EP181_RS03745	COG1677	Flagellar hook-basal body complex protein FliE
EP181_RS03755	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EP181_RS03790	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EP181_RS03795	COG1360	Flagellar Motor Protein
EP181_RS03835	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EP181_RS03840	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EP181_RS03870	COG2198	Histidine kinase
EP181_RS03870	COG0643	Histidine kinase
EP181_RS03870	COG0784	Response regulator, receiver
EP181_RS03875	COG0835	chemotaxis
EP181_RS03895	COG0835	chemotaxis
EP181_RS03910	COG2201	protein-glutamate methylesterase activity
EP181_RS03915	COG0840	transmembrane signaling receptor activity
EP181_RS03925	COG3040	lipid binding
EP181_RS03935	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EP181_RS03950	COG0840	transmembrane signaling receptor activity
EP181_RS03960	COG0835	chemotaxis
EP181_RS03975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EP181_RS03980	COG0481	GTPase activity
EP181_RS03990	COG0571	ribonuclease III activity
EP181_RS03995	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EP181_RS04000	COG1381	Involved in DNA repair and RecF pathway recombination
EP181_RS04005	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EP181_RS04010	COG0736	holo-[acyl-carrier-protein] synthase activity
EP181_RS04020	COG2200	EAL domain
EP181_RS04060	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EP181_RS04070	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EP181_RS04080	COG0004	ammonium transporteR
EP181_RS04090	COG0840	transmembrane signaling receptor activity
EP181_RS04090	COG0840	transmembrane signaling receptor activity
EP181_RS04095	COG1716	ATPase activity
EP181_RS04095	COG5001	Diguanylate cyclase
EP181_RS04110	COG2801	Transposase and inactivated derivatives
EP181_RS04115	COG2199	diguanylate cyclase activity
EP181_RS04125	COG0840	transmembrane signaling receptor activity
EP181_RS04165	COG1136	(ABC) transporter
EP181_RS04175	COG0658	competence protein
EP181_RS04175	COG2333	competence protein COMEC
EP181_RS04180	COG1663	tetraacyldisaccharide 4'-kinase activity
EP181_RS04185	COG2835	tetraacyldisaccharide 4'-kinase activity
EP181_RS04190	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EP181_RS04205	COG0561	phosphatase activity
EP181_RS04210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EP181_RS04215	COG1321	iron dependent repressor
EP181_RS04215	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EP181_RS04220	COG1121	(ABC) transporter
EP181_RS04235	COG0602	queuosine metabolic process
EP181_RS04240	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EP181_RS04245	COG0066	3-isopropylmalate dehydratase activity
EP181_RS04255	COG0739	heme binding
EP181_RS04260	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EP181_RS04265	COG0101	tRNA pseudouridine synthase activity
EP181_RS04270	COG0135	phosphoribosylanthranilate isomerase activity
EP181_RS04280	COG0159	tryptophan synthase activity
EP181_RS04290	COG0285	dihydrofolate synthase activity
EP181_RS04315	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EP181_RS04320	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EP181_RS04325	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EP181_RS04330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EP181_RS04335	COG0149	triose-phosphate isomerase activity
EP181_RS04350	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EP181_RS04355	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EP181_RS04360	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EP181_RS04365	COG0649	NAD binding
EP181_RS04380	COG1034	ATP synthesis coupled electron transport
EP181_RS04385	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EP181_RS04390	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EP181_RS04400	COG0713	ATP synthesis coupled electron transport
EP181_RS04415	COG1007	ATP synthesis coupled electron transport
EP181_RS04425	COG0668	transmembrane transport
EP181_RS04450	COG1028	Short-chain dehydrogenase reductase Sdr
EP181_RS04455	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EP181_RS04460	COG0277	FAD linked oxidase domain protein
EP181_RS04465	COG0277	FAD linked oxidase domain protein
EP181_RS04485	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
EP181_RS04500	COG1492	cobalamin metabolic process
EP181_RS04530	COG0497	DNA recombination
EP181_RS04535	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EP181_RS04540	COG1420	regulation of RNA biosynthetic process
EP181_RS04545	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EP181_RS04550	COG0443	Heat shock 70 kDa protein
EP181_RS04555	COG0484	heat shock protein binding
EP181_RS04560	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EP181_RS04565	COG0791	NLP P60 protein
EP181_RS04570	COG0505	Belongs to the CarA family
EP181_RS04580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EP181_RS04595	COG2833	Protein of unknown function (DUF455)
EP181_RS04605	COG1940	carbohydrate kinase activity
EP181_RS04610	COG1278	Cold shock
EP181_RS04615	COG0513	Belongs to the DEAD box helicase family
EP181_RS04650	COG0300	oxidoreductase activity
EP181_RS04655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EP181_RS04665	COG2205	protein histidine kinase activity
EP181_RS04665	COG5002	protein histidine kinase activity
EP181_RS04665	COG0784	Response regulator, receiver
EP181_RS04685	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EP181_RS04695	COG3550	peptidyl-serine autophosphorylation
EP181_RS04700	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
EP181_RS04705	COG1091	dTDP-4-dehydrorhamnose reductase activity
EP181_RS04730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EP181_RS04735	COG0250	Participates in transcription elongation, termination and antitermination
EP181_RS04760	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EP181_RS04795	COG2244	polysaccharide biosynthetic process
EP181_RS04810	COG0367	asparagine synthase
EP181_RS04820	COG0438	transferase activity, transferring glycosyl groups
EP181_RS04830	COG0438	transferase activity, transferring glycosyl groups
EP181_RS04850	COG4584	PFAM Integrase catalytic
EP181_RS04855	COG1484	DNA-dependent DNA replication
EP181_RS04875	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EP181_RS04920	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EP181_RS04925	COG0352	thiamine-phosphate diphosphorylase activity
EP181_RS04935	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EP181_RS04950	COG1999	signal sequence binding
EP181_RS04960	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EP181_RS04985	COG2183	response to ionizing radiation
EP181_RS04995	COG0717	Belongs to the dCTP deaminase family
EP181_RS05005	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EP181_RS05010	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EP181_RS05020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EP181_RS05060	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EP181_RS05065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EP181_RS05075	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EP181_RS05095	COG3122	Protein conserved in bacteria
EP181_RS05100	COG0616	signal peptide processing
EP181_RS05105	COG0322	excinuclease ABC activity
EP181_RS05130	COG2850	peptidyl-arginine hydroxylation
EP181_RS05140	COG1047	Peptidyl-prolyl cis-trans
EP181_RS05145	COG1981	membrane
EP181_RS05155	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EP181_RS05160	COG0450	alkyl hydroperoxide reductase
EP181_RS05175	COG0826	peptidase U32
EP181_RS05180	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EP181_RS05200	COG2954	triphosphatase activity
EP181_RS05215	COG1376	ErfK ybiS ycfS ynhG family protein
EP181_RS05220	COG0601	transmembrane transport
EP181_RS05225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EP181_RS05235	COG1472	Belongs to the glycosyl hydrolase 3 family
EP181_RS05240	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EP181_RS05245	COG1199	ATP-dependent helicase activity
EP181_RS05270	COG1944	ATP diphosphatase activity
EP181_RS05280	COG0825	malonyl-CoA metabolic process
EP181_RS05285	COG0037	tRNA processing
EP181_RS05290	COG0504	CTP synthase activity
EP181_RS05300	COG0148	phosphopyruvate hydratase activity
EP181_RS05305	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EP181_RS05310	COG2840	Smr protein MutS2
EP181_RS05315	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EP181_RS05320	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EP181_RS05325	COG1238	metal cluster binding
EP181_RS05340	COG0436	Aminotransferase
EP181_RS05350	COG3707	response regulator
EP181_RS05355	COG2308	Evidence 4 Homologs of previously reported genes of
EP181_RS05380	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
EP181_RS05390	COG1047	Peptidyl-prolyl cis-trans
EP181_RS05395	COG0446	pyridine nucleotide-disulphide oxidoreductase
EP181_RS05415	COG0205	6-phosphofructokinase activity
EP181_RS05420	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EP181_RS05425	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EP181_RS05430	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EP181_RS05440	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EP181_RS05445	COG0720	synthase
EP181_RS05450	COG0142	geranyltranstransferase activity
EP181_RS05465	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EP181_RS05470	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EP181_RS05475	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EP181_RS05480	COG0632	four-way junction helicase activity
EP181_RS05485	COG2255	four-way junction helicase activity
EP181_RS05505	COG0823	Involved in the tonB-independent uptake of proteins
EP181_RS05510	COG2885	chlorophyll binding
EP181_RS05520	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EP181_RS05550	COG2204	response regulator
EP181_RS05565	COG0688	phosphatidylethanolamine metabolic process
EP181_RS05570	COG0137	argininosuccinate synthase activity
EP181_RS05575	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EP181_RS05580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EP181_RS05585	COG1301	dicarboxylic acid transport
EP181_RS05595	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EP181_RS05600	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EP181_RS05610	COG0215	cysteine-tRNA ligase activity
EP181_RS05620	COG0791	NLP P60 protein
EP181_RS05620	COG1388	LysM domain
EP181_RS05625	COG1388	LysM domain
EP181_RS05625	COG0741	lytic transglycosylase activity
EP181_RS05630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EP181_RS05640	COG2226	methyltransferase
EP181_RS05645	COG0328	RNA-DNA hybrid ribonuclease activity
EP181_RS05650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EP181_RS05655	COG0544	peptidyl-prolyl cis-trans isomerase activity
EP181_RS05660	COG0740	serine-type endopeptidase activity
EP181_RS05665	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EP181_RS05670	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EP181_RS05710	COG0783	Belongs to the Dps family
EP181_RS05720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EP181_RS05730	COG0513	Belongs to the DEAD box helicase family
EP181_RS05735	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EP181_RS05750	COG0328	RNA-DNA hybrid ribonuclease activity
EP181_RS05765	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EP181_RS05770	COG4660	Part of a membrane complex involved in electron transport
EP181_RS05775	COG4659	FMN binding
EP181_RS05785	COG4656	Part of a membrane complex involved in electron transport
EP181_RS05790	COG2878	Part of a membrane complex involved in electron transport
EP181_RS05795	COG4657	Part of a membrane complex involved in electron transport
EP181_RS05810	COG0489	protein tyrosine kinase activity
EP181_RS05815	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EP181_RS05820	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EP181_RS05825	COG1923	regulation of RNA biosynthetic process
EP181_RS05830	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EP181_RS05840	COG0330	HflC and HflK could
EP181_RS05850	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EP181_RS05855	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EP181_RS05870	COG2915	High frequency lysogenization protein hflD homolog
EP181_RS05875	COG0482	sulfurtransferase activity
EP181_RS05880	COG1187	pseudouridine synthase activity
EP181_RS05890	COG3106	COG3106 Predicted ATPase
EP181_RS05915	COG2824	Alkylphosphonate utilization operon protein PhnA
EP181_RS05920	COG0484	heat shock protein binding
EP181_RS05925	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EP181_RS05935	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EP181_RS05940	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EP181_RS05950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EP181_RS05955	COG3162	membrane
EP181_RS05975	COG2176	DNA-directed DNA polymerase activity
EP181_RS05980	COG0779	Required for maturation of 30S ribosomal subunits
EP181_RS05985	COG2251	uridine kinase activity
EP181_RS05985	COG0195	Participates in both transcription termination and antitermination
EP181_RS05990	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EP181_RS06000	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EP181_RS06005	COG0500	methyltransferase
EP181_RS06015	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EP181_RS06020	COG1185	polyribonucleotide nucleotidyltransferase activity
EP181_RS06040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EP181_RS06045	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EP181_RS06050	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EP181_RS06065	COG2022	thiamine diphosphate biosynthetic process
EP181_RS06080	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EP181_RS06090	COG0446	pyridine nucleotide-disulphide oxidoreductase
EP181_RS06105	COG1136	(ABC) transporter
EP181_RS06110	COG0488	(ABC) transporter
EP181_RS06120	COG0747	negative chemotaxis
EP181_RS06125	COG0601	transmembrane transport
EP181_RS06130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EP181_RS06140	COG1028	Short-chain dehydrogenase reductase Sdr
EP181_RS06150	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EP181_RS06160	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EP181_RS06170	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EP181_RS06175	COG0287	Prephenate dehydrogenase
EP181_RS06180	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EP181_RS06185	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EP181_RS06195	COG0776	regulation of translation
EP181_RS06205	COG0284	orotidine-5'-phosphate decarboxylase activity
EP181_RS06210	COG0360	Binds together with S18 to 16S ribosomal RNA
EP181_RS06225	COG0359	binds to the 23S rRNA
EP181_RS06240	COG0494	nUDIX hydrolase
EP181_RS06295	COG1570	exodeoxyribonuclease VII activity
EP181_RS06300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EP181_RS06330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EP181_RS06335	COG0363	glucosamine-6-phosphate deaminase activity
EP181_RS06340	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EP181_RS06345	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EP181_RS06370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EP181_RS06380	COG2900	Belongs to the SlyX family
EP181_RS06385	COG2996	Protein conserved in bacteria
EP181_RS06390	COG1187	pseudouridine synthase activity
EP181_RS06395	COG1994	Peptidase M50
EP181_RS06400	COG0009	L-threonylcarbamoyladenylate synthase
EP181_RS06405	COG0613	PHP domain protein
EP181_RS06410	COG2917	probably involved in intracellular septation
EP181_RS06415	COG2350	Protein conserved in bacteria
EP181_RS06440	COG3028	Belongs to the UPF0307 family
EP181_RS06445	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EP181_RS06455	COG1070	Carbohydrate kinase
EP181_RS06465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EP181_RS06490	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EP181_RS06525	COG2983	Belongs to the UPF0260 family
EP181_RS06530	COG0564	pseudouridine synthase activity
EP181_RS06540	COG1051	belongs to the nudix hydrolase family
EP181_RS06550	COG0716	FMN binding
EP181_RS06580	COG0564	pseudouridine synthase activity
EP181_RS06600	COG0045	succinate-CoA ligase (ADP-forming) activity
EP181_RS06615	COG3706	GGDEF domain
EP181_RS06635	COG4628	conserved protein (DUF2132)
EP181_RS06645	COG1643	Atp-dependent helicase
EP181_RS06685	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EP181_RS06690	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EP181_RS06695	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EP181_RS06710	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EP181_RS06710	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EP181_RS06715	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EP181_RS06720	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EP181_RS06725	COG0488	(ABC) transporter
EP181_RS06745	COG0047	phosphoribosylformylglycinamidine synthase activity
EP181_RS06745	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EP181_RS06755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EP181_RS06760	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EP181_RS06765	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EP181_RS06770	COG0583	DNA-binding transcription factor activity
EP181_RS06775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EP181_RS06780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EP181_RS06785	COG0006	proline dipeptidase activity
EP181_RS06800	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EP181_RS06805	COG0860	N-Acetylmuramoyl-L-alanine amidase
EP181_RS06810	COG1388	LysM domain
EP181_RS06810	COG0860	N-Acetylmuramoyl-L-alanine amidase
EP181_RS06840	COG3784	Protein of unknown function (DUF1318)
EP181_RS06845	COG2982	Protein involved in outer membrane biogenesis
EP181_RS06855	COG0442	prolyl-tRNA aminoacylation
EP181_RS06860	COG3123	guanosine phosphorylase activity
EP181_RS06870	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EP181_RS06875	COG0835	chemotaxis
EP181_RS06875	COG0784	Response regulator, receiver
EP181_RS06880	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EP181_RS06885	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EP181_RS06890	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EP181_RS06895	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EP181_RS06900	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EP181_RS06910	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EP181_RS06915	COG0750	zinc metalloprotease
EP181_RS06920	COG0575	Belongs to the CDS family
EP181_RS06930	COG0233	cytoplasmic translational termination
EP181_RS06935	COG0528	UMP kinase activity
EP181_RS06940	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EP181_RS06945	COG0052	Belongs to the universal ribosomal protein uS2 family
EP181_RS06950	COG0024	Methionine aminopeptidase
EP181_RS06955	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EP181_RS06970	COG1393	Belongs to the ArsC family
EP181_RS06975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EP181_RS06990	COG0733	neurotransmitter:sodium symporter activity
EP181_RS06995	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EP181_RS07000	COG0640	Transcriptional regulator
EP181_RS07005	COG0701	Predicted permease
EP181_RS07015	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EP181_RS07025	COG0659	secondary active sulfate transmembrane transporter activity
EP181_RS07040	COG0582	viral genome integration into host DNA
EP181_RS07055	COG5001	Diguanylate cyclase
EP181_RS07055	COG1716	ATPase activity
EP181_RS07060	COG4584	PFAM Integrase catalytic
EP181_RS07065	COG1484	DNA-dependent DNA replication
EP181_RS07090	COG1252	NADH dehydrogenase
EP181_RS07100	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EP181_RS07110	COG2914	Belongs to the UPF0125 (RnfH) family
EP181_RS07115	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EP181_RS07120	COG0735	belongs to the Fur family
EP181_RS07130	COG3206	protein involved in exopolysaccharide biosynthesis
EP181_RS07130	COG0489	protein tyrosine kinase activity
EP181_RS07135	COG1643	Atp-dependent helicase
EP181_RS07155	COG0521	Mo-molybdopterin cofactor biosynthetic process
EP181_RS07180	COG4181	ATPase activity
EP181_RS07195	COG3046	protein related to deoxyribodipyrimidine photolyase
EP181_RS07205	COG0415	Belongs to the DNA photolyase family
EP181_RS07215	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EP181_RS07255	COG1792	Involved in formation and maintenance of cell shape
EP181_RS07270	COG0772	Belongs to the SEDS family
EP181_RS07275	COG1686	Belongs to the peptidase S11 family
EP181_RS07285	COG2921	Belongs to the UPF0250 family
EP181_RS07295	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EP181_RS07300	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EP181_RS07305	COG3022	response to hydroperoxide
EP181_RS07320	COG1714	RDD family
EP181_RS07330	COG1187	pseudouridine synthase activity
EP181_RS07335	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EP181_RS07350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EP181_RS07355	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EP181_RS07360	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EP181_RS07365	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EP181_RS07375	COG0123	including yeast histone deacetylase and acetoin utilization protein
EP181_RS07385	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EP181_RS07390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EP181_RS07395	COG1295	ribonuclease BN
EP181_RS07395	COG1959	2 iron, 2 sulfur cluster binding
EP181_RS07400	COG0693	protein deglycase activity
EP181_RS07405	COG0793	Belongs to the peptidase S41A family
EP181_RS07435	COG3108	Peptidase M15
EP181_RS07440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EP181_RS07445	COG0058	SHG alpha-glucan phosphorylase activity
EP181_RS07450	COG0297	glycogen (starch) synthase activity
EP181_RS07455	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EP181_RS07470	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EP181_RS07475	COG0837	glucose binding
EP181_RS07485	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EP181_RS07485	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EP181_RS07495	COG0517	IMP dehydrogenase activity
EP181_RS07495	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EP181_RS07500	COG1519	Transferase
EP181_RS07510	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EP181_RS07515	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EP181_RS07525	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EP181_RS07540	COG2226	methyltransferase
EP181_RS07550	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EP181_RS07565	COG0840	transmembrane signaling receptor activity
EP181_RS07565	COG0840	transmembrane signaling receptor activity
EP181_RS07575	COG0589	response to stress
EP181_RS07630	COG1459	type II secretion system
EP181_RS07635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EP181_RS07655	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EP181_RS07665	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EP181_RS07670	COG2199	diguanylate cyclase activity
EP181_RS07670	COG2200	EAL domain
EP181_RS07675	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EP181_RS07680	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EP181_RS07685	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EP181_RS07690	COG2203	Gaf domain
EP181_RS07690	COG2199	diguanylate cyclase activity
EP181_RS07700	COG0189	ligase activity
EP181_RS07705	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EP181_RS07710	COG0732	type I restriction modification DNA specificity domain
EP181_RS07725	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EP181_RS07735	COG1678	Uncharacterized ACR, COG1678
EP181_RS07740	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EP181_RS07745	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EP181_RS07750	COG0540	Belongs to the ATCase OTCase family
EP181_RS07755	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EP181_RS07770	COG2326	polyphosphate kinase activity
EP181_RS07780	COG0840	transmembrane signaling receptor activity
EP181_RS07805	COG0762	integral membrane protein
EP181_RS07810	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EP181_RS07825	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EP181_RS07840	COG1538	Outer membrane efflux protein
EP181_RS07845	COG2945	thiolester hydrolase activity
EP181_RS07850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EP181_RS07865	COG2161	toxin-antitoxin pair type II binding
EP181_RS07885	COG3030	protein affecting phage T7 exclusion by the F plasmid
EP181_RS07890	COG4232	protein-disulfide reductase activity
EP181_RS07895	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EP181_RS07900	COG0511	ligase activity, forming carbon-carbon bonds
EP181_RS07915	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EP181_RS07920	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EP181_RS07940	COG0542	response to heat
EP181_RS07950	COG1322	Protein conserved in bacteria
EP181_RS07980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EP181_RS07990	COG1450	Type ii and iii secretion system protein
EP181_RS08010	COG3409	Peptidoglycan-binding domain 1 protein
EP181_RS08010	COG3267	Type II secretory pathway component ExeA
EP181_RS08055	COG0424	maF-like protein
EP181_RS08065	COG0277	FAD linked oxidase domain protein
EP181_RS08065	COG0247	lactate metabolic process
EP181_RS08120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EP181_RS08125	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EP181_RS08130	COG2194	sulfuric ester hydrolase activity
EP181_RS08140	COG1132	(ABC) transporter
EP181_RS08145	COG1560	Kdo2-lipid A biosynthetic process
EP181_RS08150	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EP181_RS08155	COG3177	Filamentation induced by cAMP protein fic
EP181_RS08160	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EP181_RS08165	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EP181_RS08170	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EP181_RS08215	COG4964	Belongs to the GSP D family
EP181_RS08260	COG0400	carboxylic ester hydrolase activity
EP181_RS08270	COG0019	diaminopimelate decarboxylase activity
EP181_RS08285	COG0509	glycine decarboxylation via glycine cleavage system
EP181_RS08290	COG3706	GGDEF domain
EP181_RS08295	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EP181_RS08300	COG0799	negative regulation of ribosome biogenesis
EP181_RS08305	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EP181_RS08310	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EP181_RS08325	COG0495	leucyl-tRNA aminoacylation
EP181_RS08335	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EP181_RS08340	COG4535	Mg2 and Co2 transporter CorC
EP181_RS08345	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EP181_RS08350	COG1702	phosphate starvation-inducible protein PhoH
EP181_RS08355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EP181_RS08375	COG4115	mRNA cleavage
EP181_RS08380	COG2161	toxin-antitoxin pair type II binding
EP181_RS08385	COG2204	response regulator
EP181_RS08415	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EP181_RS08420	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EP181_RS08435	COG0196	riboflavin kinase activity
EP181_RS08445	COG0268	Binds directly to 16S ribosomal RNA
EP181_RS08450	COG1218	3'(2'),5'-bisphosphate nucleotidase
EP181_RS08465	COG0500	methyltransferase
EP181_RS08475	COG4456	Virulence-associated protein
EP181_RS08485	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EP181_RS08490	COG0488	(ABC) transporter
EP181_RS08500	COG0271	Belongs to the BolA IbaG family
EP181_RS08525	COG0306	phosphate transporter
EP181_RS08535	COG0745	RESPONSE REGULATOR receiver
EP181_RS08545	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EP181_RS08555	COG1177	transmembrane transport
EP181_RS08560	COG0174	glutamine synthetase
EP181_RS08580	COG0004	ammonium transporteR
EP181_RS08595	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EP181_RS08600	COG0525	valine-tRNA ligase activity
EP181_RS08605	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EP181_RS08615	COG0335	large ribosomal subunit rRNA binding
EP181_RS08620	COG0336	Belongs to the RNA methyltransferase TrmD family
EP181_RS08625	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EP181_RS08630	COG0228	four-way junction DNA binding
EP181_RS08635	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EP181_RS08645	COG4536	flavin adenine dinucleotide binding
EP181_RS08655	COG0784	Response regulator, receiver
EP181_RS08655	COG5002	protein histidine kinase activity
EP181_RS08655	COG2198	Histidine kinase
EP181_RS08665	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EP181_RS08670	COG2857	Cytochrome c1
EP181_RS08675	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EP181_RS08685	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EP181_RS08690	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EP181_RS08695	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EP181_RS08700	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EP181_RS08705	COG0271	Belongs to the BolA IbaG family
EP181_RS08710	COG0842	Transport permease protein
EP181_RS08715	COG1131	(ABC) transporter
EP181_RS08730	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EP181_RS08740	COG1127	ABC transporter
EP181_RS08755	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EP181_RS08780	COG2239	Acts as a magnesium transporter
EP181_RS08785	COG2885	chlorophyll binding
EP181_RS08790	COG5001	Diguanylate cyclase
EP181_RS08795	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EP181_RS08800	COG0628	permease
EP181_RS08805	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EP181_RS08810	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EP181_RS08820	COG0343	queuine tRNA-ribosyltransferase activity
EP181_RS08830	COG5001	Diguanylate cyclase
EP181_RS08830	COG3300	MHYT domain
EP181_RS08860	COG2801	Transposase and inactivated derivatives
EP181_RS08880	COG2801	Transposase and inactivated derivatives
EP181_RS08945	COG0795	lipopolysaccharide-transporting ATPase activity
EP181_RS08955	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EP181_RS08985	COG0556	nucleotide-excision repair
EP181_RS08990	COG0436	Aminotransferase
EP181_RS08995	COG1793	dna ligase
EP181_RS09000	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EP181_RS09005	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EP181_RS09045	COG5001	Diguanylate cyclase
EP181_RS09045	COG3300	MHYT domain
EP181_RS09050	COG0523	cobalamin synthesis protein
EP181_RS09085	COG2801	Transposase and inactivated derivatives
EP181_RS09095	COG2205	protein histidine kinase activity
EP181_RS09095	COG0784	Response regulator, receiver
EP181_RS09105	COG0784	Response regulator, receiver
EP181_RS09105	COG2205	protein histidine kinase activity
EP181_RS09110	COG2205	protein histidine kinase activity
EP181_RS09110	COG4999	Histidine kinase
EP181_RS09110	COG3850	Histidine kinase
EP181_RS09110	COG3437	response regulator, receiver
EP181_RS09120	COG3850	Histidine kinase
EP181_RS09120	COG3437	response regulator, receiver
EP181_RS09120	COG4999	Histidine kinase
EP181_RS09120	COG2205	protein histidine kinase activity
EP181_RS09125	COG2205	protein histidine kinase activity
EP181_RS09125	COG3437	response regulator, receiver
EP181_RS09125	COG4999	Histidine kinase
EP181_RS09125	COG3850	Histidine kinase
EP181_RS09130	COG3706	GGDEF domain
EP181_RS09135	COG0840	transmembrane signaling receptor activity
EP181_RS09135	COG0840	transmembrane signaling receptor activity
EP181_RS09180	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EP181_RS09185	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EP181_RS09190	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EP181_RS09230	COG2198	Histidine kinase
EP181_RS09230	COG0784	Response regulator, receiver
EP181_RS09230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP181_RS09230	COG2205	protein histidine kinase activity
EP181_RS09235	COG0784	Response regulator, receiver
EP181_RS09235	COG5002	protein histidine kinase activity
EP181_RS09250	COG2205	protein histidine kinase activity
EP181_RS09250	COG5002	protein histidine kinase activity
EP181_RS09250	COG0784	Response regulator, receiver
EP181_RS09255	COG4999	Histidine kinase
EP181_RS09255	COG2205	protein histidine kinase activity
EP181_RS09255	COG3437	response regulator, receiver
EP181_RS09255	COG3850	Histidine kinase
EP181_RS09290	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EP181_RS09295	COG5002	protein histidine kinase activity
EP181_RS09295	COG0784	Response regulator, receiver
EP181_RS09320	COG0579	oxidoreductase
EP181_RS09325	COG0523	cobalamin synthesis protein
EP181_RS09330	COG1469	GTP cyclohydrolase I activity
EP181_RS09335	COG0513	Belongs to the DEAD box helicase family
EP181_RS09340	COG1611	Belongs to the LOG family
EP181_RS09345	COG0628	permease
EP181_RS09350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EP181_RS09360	COG1012	belongs to the aldehyde dehydrogenase family
EP181_RS09370	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EP181_RS09380	COG5001	Diguanylate cyclase
EP181_RS09380	COG1716	ATPase activity
EP181_RS09390	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EP181_RS09405	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EP181_RS09420	COG5001	Diguanylate cyclase
EP181_RS09430	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EP181_RS09435	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EP181_RS09455	COG0668	transmembrane transport
EP181_RS09460	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EP181_RS09465	COG1666	GTP binding
EP181_RS09470	COG0756	dUTP diphosphatase activity
EP181_RS09480	COG1970	mechanosensitive ion channel activity
EP181_RS09485	COG2200	EAL domain
EP181_RS09485	COG3287	FIST C domain
EP181_RS09485	COG2199	diguanylate cyclase activity
EP181_RS09490	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EP181_RS09495	COG2801	Transposase and inactivated derivatives
EP181_RS09505	COG3038	cytochrome b561
EP181_RS09515	COG2003	Belongs to the UPF0758 family
EP181_RS09520	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EP181_RS09535	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
EP181_RS09550	COG3038	cytochrome b561
EP181_RS09555	COG0446	pyridine nucleotide-disulphide oxidoreductase
EP181_RS09580	COG1858	cytochrome C peroxidase
EP181_RS09585	COG1373	ATPase (AAA superfamily
EP181_RS09605	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EP181_RS09610	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EP181_RS09620	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EP181_RS09635	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EP181_RS09640	COG0742	ribosomal rna small subunit methyltransferase
EP181_RS09650	COG0612	Peptidase, M16
EP181_RS09655	COG0612	Peptidase, M16
EP181_RS09660	COG0552	protein localization to endoplasmic reticulum
EP181_RS09680	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EP181_RS09690	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EP181_RS09725	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EP181_RS09735	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EP181_RS09740	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EP181_RS09745	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EP181_RS09750	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EP181_RS09760	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EP181_RS09775	COG0069	glutamate synthase activity
EP181_RS09775	COG0067	glutamate synthase
EP181_RS09775	COG0070	glutamate synthase
EP181_RS09780	COG0493	'glutamate synthase
EP181_RS09805	COG0840	transmembrane signaling receptor activity
EP181_RS09810	COG0746	molybdenum cofactor guanylyltransferase activity
EP181_RS09820	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EP181_RS09825	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EP181_RS09825	COG1648	precorrin-2 dehydrogenase activity
EP181_RS09830	COG0243	molybdopterin cofactor binding
EP181_RS09840	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EP181_RS09845	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EP181_RS09850	COG1116	anion transmembrane transporter activity
EP181_RS09855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EP181_RS09860	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EP181_RS09870	COG5002	protein histidine kinase activity
EP181_RS09870	COG0784	Response regulator, receiver
EP181_RS09870	COG2205	protein histidine kinase activity
EP181_RS09900	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EP181_RS09905	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EP181_RS09920	COG4771	TonB-dependent receptor
EP181_RS09925	COG4771	TonB-dependent receptor
EP181_RS09940	COG0033	Phosphoglucomutase
EP181_RS09960	COG3706	GGDEF domain
EP181_RS09965	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EP181_RS10005	COG0390	transport system, permease component
EP181_RS10010	COG3842	ATPase activity
EP181_RS10015	COG0210	DNA helicase
EP181_RS10025	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EP181_RS10030	COG0254	rRNA binding
EP181_RS10040	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EP181_RS10050	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EP181_RS10060	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EP181_RS10070	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EP181_RS10075	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EP181_RS10080	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EP181_RS10090	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EP181_RS10095	COG0523	cobalamin synthesis protein
EP181_RS10110	COG0563	adenylate kinase activity
EP181_RS10115	COG1067	ATP-dependent peptidase activity
EP181_RS10125	COG0189	ligase activity
EP181_RS10130	COG0189	ligase activity
EP181_RS10130	COG4067	protein conserved in archaea
EP181_RS10135	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EP181_RS10135	COG3264	Mechanosensitive ion channel
EP181_RS10145	COG1511	domain protein
EP181_RS10145	COG3264	Mechanosensitive ion channel
EP181_RS10150	COG2205	protein histidine kinase activity
EP181_RS10150	COG0784	Response regulator, receiver
EP181_RS10170	COG2211	Major facilitator Superfamily
EP181_RS10180	COG4221	oxidoreductase activity
EP181_RS10195	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EP181_RS10215	COG1366	Belongs to the anti-sigma-factor antagonist family
EP181_RS10225	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EP181_RS10235	COG0259	pyridoxamine-phosphate oxidase activity
EP181_RS10240	COG1090	epimerase
EP181_RS10265	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
EP181_RS10270	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
EP181_RS10310	COG1192	Involved in chromosome partitioning
EP181_RS10320	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
EP181_RS10325	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
EP181_RS10350	COG1850	ribulose-bisphosphate carboxylase activity
EP181_RS10355	COG0583	DNA-binding transcription factor activity
EP181_RS10385	COG3328	transposase activity
EP181_RS10405	COG0840	transmembrane signaling receptor activity
EP181_RS10425	COG0745	RESPONSE REGULATOR receiver
EP181_RS10490	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EP181_RS10540	COG2337	Toxic component of a toxin-antitoxin (TA) module
EP181_RS10550	COG1854	S-ribosylhomocysteine lyase activity
EP181_RS10555	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EP181_RS10570	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
EP181_RS10585	COG4772	TonB-dependent receptor
EP181_RS10595	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EP181_RS10605	COG1175	transmembrane transport
EP181_RS10615	COG0577	efflux transmembrane transporter activity
EP181_RS10615	COG1136	(ABC) transporter
EP181_RS10620	COG0577	efflux transmembrane transporter activity
EP181_RS10620	COG1136	(ABC) transporter
EP181_RS10630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EP181_RS10640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EP181_RS10675	COG2199	diguanylate cyclase activity
EP181_RS10685	COG3706	GGDEF domain
EP181_RS10700	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EP181_RS10710	COG1451	nucleotide metabolic process
EP181_RS10730	COG1902	pentaerythritol trinitrate reductase activity
EP181_RS10735	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EP181_RS10750	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EP181_RS10755	COG3842	ATPase activity
EP181_RS10760	COG1176	ABC-type spermidine putrescine transport system, permease component I
EP181_RS10765	COG1177	transmembrane transport
EP181_RS10770	COG3177	Filamentation induced by cAMP protein fic
EP181_RS10780	COG0477	Major facilitator Superfamily
EP181_RS10800	COG1136	(ABC) transporter
EP181_RS10805	COG0577	efflux transmembrane transporter activity
EP181_RS10805	COG1136	(ABC) transporter
EP181_RS10830	COG0676	glucose-6-phosphate 1-epimerase activity
EP181_RS10840	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EP181_RS10855	COG0194	GDP metabolic process
EP181_RS10860	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EP181_RS10865	COG1454	alcohol dehydrogenase
EP181_RS10870	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EP181_RS10880	COG1758	RNA polymerase activity
EP181_RS10885	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EP181_RS10925	COG1115	amino acid carrier protein
EP181_RS10935	COG0217	transcriptional regulatory protein
EP181_RS10940	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EP181_RS10945	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EP181_RS10975	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EP181_RS11015	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EP181_RS11020	COG3161	chorismate lyase activity
EP181_RS11050	COG0840	transmembrane signaling receptor activity
EP181_RS11065	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EP181_RS11080	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EP181_RS11085	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EP181_RS11095	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EP181_RS11100	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EP181_RS11105	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EP181_RS11110	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EP181_RS11115	COG0356	it plays a direct role in the translocation of protons across the membrane
EP181_RS11135	COG1192	Involved in chromosome partitioning
EP181_RS11145	COG0445	tRNA wobble uridine modification
EP181_RS11155	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EP181_RS11155	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EP181_RS11195	COG1739	Uncharacterized protein family UPF0029
EP181_RS11200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EP181_RS11210	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EP181_RS11220	COG0706	membrane insertase activity
EP181_RS11225	COG0594	ribonuclease P activity
EP181_RS11230	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EP181_RS11235	COG1238	metal cluster binding
EP181_RS11240	COG0730	response to heat
EP181_RS11375	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EP181_RS11405	COG0629	single-stranded DNA binding
EP181_RS11665	COG0681	Belongs to the peptidase S26 family
EP181_RS11695	COG0210	DNA helicase
EP181_RS11710	COG1714	RDD family
EP181_RS11815	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)