locus-tag	class	description
HRR27_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HRR27_RS00010	COG0592	DNA-directed DNA polymerase activity
HRR27_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HRR27_RS00030	COG0187	DNA topoisomerase II activity
HRR27_RS00055	COG4372	Transposase
HRR27_RS00060	COG3436	PFAM IS66 Orf2 family protein
HRR27_RS00080	COG2433	Pfam Transposase IS66
HRR27_RS00085	COG0363	glucosamine-6-phosphate deaminase activity
HRR27_RS00090	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HRR27_RS00095	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HRR27_RS00105	COG1595	DNA-templated transcription, initiation
HRR27_RS00150	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HRR27_RS00160	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HRR27_RS00165	COG2853	Lipoprotein
HRR27_RS00175	COG0778	Nitroreductase
HRR27_RS00190	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HRR27_RS00195	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HRR27_RS00200	COG1333	cytochrome c biogenesis protein
HRR27_RS00205	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HRR27_RS00215	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRR27_RS00215	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRR27_RS00220	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HRR27_RS00225	COG0009	L-threonylcarbamoyladenylate synthase
HRR27_RS00240	COG0408	coproporphyrinogen oxidase activity
HRR27_RS00245	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HRR27_RS00265	COG1320	monovalent cation:proton antiporter activity
HRR27_RS00270	COG2212	antiporter activity
HRR27_RS00280	COG0651	ATP synthesis coupled electron transport
HRR27_RS00285	COG1006	Multisubunit Na H antiporter MnhC subunit
HRR27_RS00290	COG2111	Na H antiporter
HRR27_RS00290	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HRR27_RS00300	COG5001	Diguanylate cyclase
HRR27_RS00305	COG4372	Transposase
HRR27_RS00310	COG2433	Pfam Transposase IS66
HRR27_RS00320	COG2433	Pfam Transposase IS66
HRR27_RS00325	COG2433	Pfam Transposase IS66
HRR27_RS00345	COG1283	sodium-dependent phosphate transmembrane transporter activity
HRR27_RS00355	COG1136	(ABC) transporter
HRR27_RS00380	COG0339	signal peptide processing
HRR27_RS00385	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HRR27_RS00405	COG5001	Diguanylate cyclase
HRR27_RS00420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRR27_RS00435	COG3038	cytochrome b561
HRR27_RS00450	COG0318	PFAM AMP-dependent synthetase and ligase
HRR27_RS00450	COG0204	Acyl-transferase
HRR27_RS00455	COG0045	succinate-CoA ligase (ADP-forming) activity
HRR27_RS00455	COG1042	CoA-binding domain protein
HRR27_RS00455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRR27_RS00460	COG0123	including yeast histone deacetylase and acetoin utilization protein
HRR27_RS00495	COG0714	Associated with various cellular activities
HRR27_RS00510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HRR27_RS00520	COG2226	methyltransferase
HRR27_RS00525	COG0500	methyltransferase
HRR27_RS00535	COG0714	Associated with various cellular activities
HRR27_RS00570	COG3118	belongs to the thioredoxin family
HRR27_RS00600	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HRR27_RS00605	COG0165	Argininosuccinate lyase
HRR27_RS00615	COG0181	hydroxymethylbilane synthase activity
HRR27_RS00640	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HRR27_RS00650	COG0708	Exodeoxyribonuclease III
HRR27_RS00660	COG0788	formyltetrahydrofolate deformylase activity
HRR27_RS00670	COG1444	tRNA N-acetyltransferase activity
HRR27_RS00675	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HRR27_RS00680	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HRR27_RS00680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRR27_RS00690	COG0351	phosphomethylpyrimidine kinase
HRR27_RS00700	COG2081	HI0933 family
HRR27_RS00725	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HRR27_RS00740	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HRR27_RS00745	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HRR27_RS00775	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HRR27_RS00780	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HRR27_RS00785	COG0314	molybdopterin synthase activity
HRR27_RS00790	COG0303	'Molybdopterin
HRR27_RS00800	COG0315	cyclic pyranopterin monophosphate synthase activity
HRR27_RS00805	COG2827	Endonuclease containing a URI domain
HRR27_RS00810	COG5002	protein histidine kinase activity
HRR27_RS00810	COG5001	Diguanylate cyclase
HRR27_RS00825	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HRR27_RS00845	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HRR27_RS00850	COG2226	methyltransferase
HRR27_RS00855	COG0596	Alpha beta hydrolase
HRR27_RS00865	COG1115	amino acid carrier protein
HRR27_RS00880	COG2308	Evidence 4 Homologs of previously reported genes of
HRR27_RS00890	COG0156	8-amino-7-oxononanoate synthase activity
HRR27_RS00895	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HRR27_RS00900	COG1040	competence protein
HRR27_RS00905	COG1230	cation diffusion facilitator family transporter
HRR27_RS00915	COG1331	Highly conserved protein containing a thioredoxin domain
HRR27_RS00925	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRR27_RS00930	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRR27_RS00935	COG0537	adenosine 5'-monophosphoramidase activity
HRR27_RS00940	COG0140	phosphoribosyl-ATP diphosphatase activity
HRR27_RS00945	COG0107	imidazoleglycerol-phosphate synthase activity
HRR27_RS00950	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HRR27_RS00955	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HRR27_RS00960	COG0131	Imidazoleglycerol-phosphate dehydratase
HRR27_RS00965	COG3278	Belongs to the heme-copper respiratory oxidase family
HRR27_RS00980	COG2010	Cytochrome c
HRR27_RS00990	COG0348	domain, Protein
HRR27_RS01000	COG2217	Heavy metal translocating P-type atpase
HRR27_RS01030	COG1490	D-aminoacyl-tRNA deacylase activity
HRR27_RS01050	COG2391	methyltransferase activity
HRR27_RS01065	COG3719	Belongs to the RNase T2 family
HRR27_RS01105	COG0513	Belongs to the DEAD box helicase family
HRR27_RS01110	COG4628	conserved protein (DUF2132)
HRR27_RS01120	COG0840	transmembrane signaling receptor activity
HRR27_RS01120	COG0840	transmembrane signaling receptor activity
HRR27_RS01125	COG0515	serine threonine protein kinase
HRR27_RS01130	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
HRR27_RS01150	COG0646	methionine synthase
HRR27_RS01150	COG1410	methionine synthase
HRR27_RS01160	COG3706	GGDEF domain
HRR27_RS01165	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HRR27_RS01170	COG0730	response to heat
HRR27_RS01200	COG0037	tRNA processing
HRR27_RS01215	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HRR27_RS01220	COG0569	domain protein
HRR27_RS01225	COG2204	response regulator
HRR27_RS01230	COG5000	phosphorelay sensor kinase activity
HRR27_RS01240	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HRR27_RS01240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HRR27_RS01245	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HRR27_RS01250	COG0242	peptide deformylase activity
HRR27_RS01255	COG0758	DNA mediated transformation
HRR27_RS01265	COG0018	arginyl-trna synthetase
HRR27_RS01280	COG2960	long-chain fatty acid transporting porin activity
HRR27_RS01285	COG0606	chelatase, subunit chli
HRR27_RS01300	COG2197	response regulator
HRR27_RS01325	COG0210	DNA helicase
HRR27_RS01330	COG2813	Specifically methylates the guanine in position
HRR27_RS01345	COG0585	pseudouridine synthase activity
HRR27_RS01350	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HRR27_RS01360	COG3769	mannosylglycerate metabolic process
HRR27_RS01365	COG1215	transferase activity, transferring glycosyl groups
HRR27_RS01375	COG1929	Belongs to the glycerate kinase type-1 family
HRR27_RS01395	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HRR27_RS01400	COG3100	YcgL domain-containing protein
HRR27_RS01410	COG0617	tRNA 3'-terminal CCA addition
HRR27_RS01440	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HRR27_RS01445	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HRR27_RS01450	COG0126	phosphoglycerate kinase activity
HRR27_RS01465	COG1850	ribulose-bisphosphate carboxylase activity
HRR27_RS01530	COG0583	DNA-binding transcription factor activity
HRR27_RS01550	COG2433	Pfam Transposase IS66
HRR27_RS01565	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HRR27_RS01575	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HRR27_RS01580	COG0546	phosphoglycolate phosphatase activity
HRR27_RS01595	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HRR27_RS01600	COG2832	Protein of unknown function (DUF454)
HRR27_RS01605	COG3550	peptidyl-serine autophosphorylation
HRR27_RS01630	COG0134	indole-3-glycerol-phosphate synthase activity
HRR27_RS01640	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HRR27_RS01645	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HRR27_RS01655	COG1765	OsmC-like protein
HRR27_RS01665	COG0513	Belongs to the DEAD box helicase family
HRR27_RS01670	COG1611	Belongs to the LOG family
HRR27_RS01675	COG0628	permease
HRR27_RS01705	COG1469	GTP cyclohydrolase I activity
HRR27_RS01710	COG0523	cobalamin synthesis protein
HRR27_RS01715	COG0579	oxidoreductase
HRR27_RS01720	COG1090	epimerase
HRR27_RS01735	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HRR27_RS01740	COG0739	heme binding
HRR27_RS01755	COG0751	glycine-tRNA ligase activity
HRR27_RS01760	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HRR27_RS01805	COG0840	transmembrane signaling receptor activity
HRR27_RS01805	COG0840	transmembrane signaling receptor activity
HRR27_RS01820	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HRR27_RS01830	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HRR27_RS01835	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HRR27_RS01845	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HRR27_RS01850	COG2890	protein-(glutamine-N5) methyltransferase activity
HRR27_RS01855	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HRR27_RS01860	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HRR27_RS01880	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HRR27_RS01885	COG0193	aminoacyl-tRNA hydrolase activity
HRR27_RS01890	COG0012	GTP binding
HRR27_RS01985	COG3436	PFAM IS66 Orf2 family protein
HRR27_RS01990	COG4372	Transposase
HRR27_RS02020	COG1116	anion transmembrane transporter activity
HRR27_RS02030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRR27_RS02050	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HRR27_RS02065	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HRR27_RS02075	COG0840	transmembrane signaling receptor activity
HRR27_RS02110	COG1459	type II secretion system
HRR27_RS02155	COG1404	Belongs to the peptidase S8 family
HRR27_RS02175	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HRR27_RS02185	COG2226	methyltransferase
HRR27_RS02195	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HRR27_RS02200	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HRR27_RS02215	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HRR27_RS02230	COG1519	Transferase
HRR27_RS02235	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HRR27_RS02235	COG0517	IMP dehydrogenase activity
HRR27_RS02240	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HRR27_RS02255	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HRR27_RS02260	COG0297	glycogen (starch) synthase activity
HRR27_RS02265	COG0058	SHG alpha-glucan phosphorylase activity
HRR27_RS02270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HRR27_RS02305	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HRR27_RS02310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRR27_RS02330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRR27_RS02385	COG2003	Belongs to the UPF0758 family
HRR27_RS02395	COG0582	viral genome integration into host DNA
HRR27_RS02405	COG3657	addiction module killer protein
HRR27_RS02420	COG0500	methyltransferase
HRR27_RS02475	COG0582	viral genome integration into host DNA
HRR27_RS02500	COG2433	Pfam Transposase IS66
HRR27_RS02550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRR27_RS02565	COG0640	Transcriptional regulator
HRR27_RS02570	COG0793	Belongs to the peptidase S41A family
HRR27_RS02575	COG0693	protein deglycase activity
HRR27_RS02585	COG1295	ribonuclease BN
HRR27_RS02590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRR27_RS02595	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HRR27_RS02615	COG2026	Addiction module toxin, RelE StbE family
HRR27_RS02620	COG3077	Addiction module antitoxin, RelB DinJ family
HRR27_RS02650	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HRR27_RS02655	COG0659	secondary active sulfate transmembrane transporter activity
HRR27_RS02660	COG0527	aspartate kinase activity
HRR27_RS02665	COG2059	Chromate
HRR27_RS02670	COG1917	Cupin 2, conserved barrel domain protein
HRR27_RS02675	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HRR27_RS02680	COG0456	acetyltransferase
HRR27_RS02690	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HRR27_RS02710	COG2205	protein histidine kinase activity
HRR27_RS02710	COG0784	Response regulator, receiver
HRR27_RS02715	COG0745	RESPONSE REGULATOR receiver
HRR27_RS02720	COG5002	protein histidine kinase activity
HRR27_RS02725	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HRR27_RS02730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRR27_RS02735	COG0500	methyltransferase
HRR27_RS02740	COG1011	Hydrolase
HRR27_RS02765	COG0831	urea catabolic process
HRR27_RS02770	COG0832	Belongs to the urease beta subunit family
HRR27_RS02775	COG0804	urea catabolic process
HRR27_RS02780	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HRR27_RS02785	COG0830	nickel cation binding
HRR27_RS02830	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HRR27_RS02835	COG0523	cobalamin synthesis protein
HRR27_RS02890	COG1555	photosystem II stabilization
HRR27_RS02895	COG1793	dna ligase
HRR27_RS02900	COG0436	Aminotransferase
HRR27_RS02905	COG0556	nucleotide-excision repair
HRR27_RS02920	COG2866	Carboxypeptidase
HRR27_RS02940	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HRR27_RS02945	COG0795	lipopolysaccharide-transporting ATPase activity
HRR27_RS02950	COG0795	lipopolysaccharide-transporting ATPase activity
HRR27_RS02955	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HRR27_RS02960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HRR27_RS02975	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HRR27_RS02980	COG3437	response regulator, receiver
HRR27_RS03040	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HRR27_RS03055	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HRR27_RS03060	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HRR27_RS03065	COG1862	Preprotein translocase
HRR27_RS03070	COG0343	queuine tRNA-ribosyltransferase activity
HRR27_RS03075	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HRR27_RS03105	COG4372	Transposase
HRR27_RS03135	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HRR27_RS03165	COG1596	polysaccharide export
HRR27_RS03175	COG4464	protein tyrosine phosphatase activity
HRR27_RS03185	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HRR27_RS03205	COG4804	nuclease activity
HRR27_RS03215	COG2244	polysaccharide biosynthetic process
HRR27_RS03220	COG1442	glycosyl transferase family 8
HRR27_RS03220	COG1216	Glycosyl transferase, family 2
HRR27_RS03225	COG0463	Glycosyl transferase, family 2
HRR27_RS03235	COG0438	transferase activity, transferring glycosyl groups
HRR27_RS03240	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HRR27_RS03245	COG0438	transferase activity, transferring glycosyl groups
HRR27_RS03255	COG2755	lipolytic protein G-D-S-L family
HRR27_RS03255	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HRR27_RS03265	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HRR27_RS03270	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HRR27_RS03285	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HRR27_RS03305	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HRR27_RS03315	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HRR27_RS03340	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HRR27_RS03350	COG2239	Acts as a magnesium transporter
HRR27_RS03360	COG1137	ATPase activity
HRR27_RS03390	COG1127	ABC transporter
HRR27_RS03395	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HRR27_RS03400	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HRR27_RS03415	COG1131	(ABC) transporter
HRR27_RS03420	COG0842	Transport permease protein
HRR27_RS03430	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HRR27_RS03435	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HRR27_RS03440	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HRR27_RS03445	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HRR27_RS03450	COG0723	plastoquinol--plastocyanin reductase activity
HRR27_RS03455	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HRR27_RS03460	COG2857	Cytochrome c1
HRR27_RS03465	COG0069	glutamate synthase activity
HRR27_RS03470	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HRR27_RS03490	COG0483	inositol monophosphate 1-phosphatase activity
HRR27_RS03495	COG4536	flavin adenine dinucleotide binding
HRR27_RS03505	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HRR27_RS03510	COG0228	four-way junction DNA binding
HRR27_RS03515	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HRR27_RS03520	COG0336	Belongs to the RNA methyltransferase TrmD family
HRR27_RS03525	COG0335	large ribosomal subunit rRNA binding
HRR27_RS03530	COG4974	Belongs to the 'phage' integrase family
HRR27_RS03535	COG2205	protein histidine kinase activity
HRR27_RS03535	COG0784	Response regulator, receiver
HRR27_RS03545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HRR27_RS03575	COG0525	valine-tRNA ligase activity
HRR27_RS03580	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HRR27_RS03595	COG0004	ammonium transporteR
HRR27_RS03600	COG0347	Belongs to the P(II) protein family
HRR27_RS03610	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HRR27_RS03615	COG0174	glutamine synthetase
HRR27_RS03625	COG0573	inorganic phosphate transmembrane transporter activity
HRR27_RS03630	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HRR27_RS03635	COG0704	Plays a role in the regulation of phosphate uptake
HRR27_RS03660	COG1858	cytochrome C peroxidase
HRR27_RS03675	COG0306	phosphate transporter
HRR27_RS03700	COG0271	Belongs to the BolA IbaG family
HRR27_RS03710	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HRR27_RS03715	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HRR27_RS03720	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HRR27_RS03725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HRR27_RS03730	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HRR27_RS03740	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HRR27_RS03745	COG0850	regulation of cytokinetic process
HRR27_RS03750	COG2894	cell division
HRR27_RS03755	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HRR27_RS03760	COG3022	response to hydroperoxide
HRR27_RS03765	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HRR27_RS03800	COG3290	protein histidine kinase activity
HRR27_RS03815	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HRR27_RS03820	COG0321	lipoyl(octanoyl) transferase activity
HRR27_RS03825	COG2921	Belongs to the UPF0250 family
HRR27_RS03830	COG1686	Belongs to the peptidase S11 family
HRR27_RS03835	COG0772	Belongs to the SEDS family
HRR27_RS03840	COG0768	penicillin binding
HRR27_RS03850	COG1792	Involved in formation and maintenance of cell shape
HRR27_RS03855	COG1077	Cell shape determining protein MreB Mrl
HRR27_RS03860	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HRR27_RS03865	COG0154	amidase activity
HRR27_RS03870	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HRR27_RS03885	COG0501	Belongs to the peptidase M48B family
HRR27_RS03895	COG2166	iron-sulfur cluster assembly
HRR27_RS03910	COG0811	peptide transport
HRR27_RS03925	COG4772	TonB-dependent receptor
HRR27_RS03930	COG0560	Phosphoserine phosphatase
HRR27_RS03955	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HRR27_RS03955	COG0519	Catalyzes the synthesis of GMP from XMP
HRR27_RS03965	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HRR27_RS03970	COG0643	Histidine kinase
HRR27_RS03970	COG2198	Histidine kinase
HRR27_RS03985	COG0326	Molecular chaperone. Has ATPase activity
HRR27_RS03990	COG5002	protein histidine kinase activity
HRR27_RS03990	COG0784	Response regulator, receiver
HRR27_RS04000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRR27_RS04020	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HRR27_RS04040	COG4942	peptidase
HRR27_RS04060	COG4372	Transposase
HRR27_RS04065	COG3436	PFAM IS66 Orf2 family protein
HRR27_RS04090	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HRR27_RS04095	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HRR27_RS04100	COG2137	regulation of response to DNA damage stimulus
HRR27_RS04105	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HRR27_RS04110	COG1546	Belongs to the CinA family
HRR27_RS04115	COG4191	Histidine kinase
HRR27_RS04115	COG0784	Response regulator, receiver
HRR27_RS04120	COG3300	MHYT domain
HRR27_RS04120	COG5001	Diguanylate cyclase
HRR27_RS04140	COG4372	Transposase
HRR27_RS04165	COG4372	Transposase
HRR27_RS04185	COG4372	Transposase
HRR27_RS04190	COG3436	PFAM IS66 Orf2 family protein
HRR27_RS04205	COG4372	Transposase
HRR27_RS04215	COG4999	Histidine kinase
HRR27_RS04215	COG3850	Histidine kinase
HRR27_RS04215	COG3437	response regulator, receiver
HRR27_RS04215	COG2205	protein histidine kinase activity
HRR27_RS04230	COG1484	DNA-dependent DNA replication
HRR27_RS04255	COG4999	Histidine kinase
HRR27_RS04255	COG3850	Histidine kinase
HRR27_RS04255	COG3437	response regulator, receiver
HRR27_RS04255	COG2205	protein histidine kinase activity
HRR27_RS04265	COG0840	transmembrane signaling receptor activity
HRR27_RS04275	COG1755	Isoprenylcysteine carboxyl methyltransferase
HRR27_RS04280	COG0617	tRNA 3'-terminal CCA addition
HRR27_RS04285	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HRR27_RS04290	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HRR27_RS04295	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HRR27_RS04300	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HRR27_RS04310	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HRR27_RS04315	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HRR27_RS04320	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HRR27_RS04325	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HRR27_RS04330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HRR27_RS04330	COG0301	tRNA thio-modification
HRR27_RS04335	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HRR27_RS04345	COG0557	exoribonuclease II activity
HRR27_RS04365	COG2885	chlorophyll binding
HRR27_RS04370	COG0308	aminopeptidase N
HRR27_RS04420	COG0835	chemotaxis
HRR27_RS04420	COG0784	Response regulator, receiver
HRR27_RS04430	COG1815	bacterial-type flagellum-dependent cell motility
HRR27_RS04440	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HRR27_RS04445	COG1749	Flagellar hook protein flgE
HRR27_RS04450	COG4786	Flagellar basal body rod
HRR27_RS04455	COG4786	Flagellar basal body rod
HRR27_RS04460	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HRR27_RS04465	COG1706	bacterial-type flagellum-dependent cell motility
HRR27_RS04480	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HRR27_RS04485	COG0741	lytic transglycosylase activity
HRR27_RS04490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRR27_RS04495	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HRR27_RS04505	COG2089	acid synthase
HRR27_RS04510	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HRR27_RS04525	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HRR27_RS04530	COG1083	cytidylyl-transferase
HRR27_RS04540	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HRR27_RS04545	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HRR27_RS04565	COG1516	flagellar protein fliS
HRR27_RS04580	COG3852	Histidine kinase
HRR27_RS04590	COG1677	Flagellar hook-basal body complex protein FliE
HRR27_RS04600	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HRR27_RS04630	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HRR27_RS04665	COG1987	bacterial-type flagellum assembly
HRR27_RS04675	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HRR27_RS04680	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HRR27_RS04705	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HRR27_RS04710	COG0784	Response regulator, receiver
HRR27_RS04710	COG2198	Histidine kinase
HRR27_RS04710	COG0643	Histidine kinase
HRR27_RS04715	COG0835	chemotaxis
HRR27_RS04720	COG2257	FlhB HrpN YscU SpaS Family
HRR27_RS04730	COG0745	RESPONSE REGULATOR receiver
HRR27_RS04735	COG0835	chemotaxis
HRR27_RS04750	COG2201	protein-glutamate methylesterase activity
HRR27_RS04755	COG0840	transmembrane signaling receptor activity
HRR27_RS04765	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HRR27_RS04775	COG0492	ferredoxin-NADP+ reductase activity
HRR27_RS04780	COG1674	ftsk spoiiie
HRR27_RS04790	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HRR27_RS04795	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HRR27_RS04800	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HRR27_RS04815	COG0582	viral genome integration into host DNA
HRR27_RS04830	COG2205	protein histidine kinase activity
HRR27_RS04835	COG0745	RESPONSE REGULATOR receiver
HRR27_RS04875	COG2204	response regulator
HRR27_RS04895	COG3106	COG3106 Predicted ATPase
HRR27_RS04905	COG4771	TonB-dependent receptor
HRR27_RS04930	COG1120	ATPase activity
HRR27_RS04935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRR27_RS04960	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HRR27_RS04975	COG2197	response regulator
HRR27_RS04980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRR27_RS05000	COG2433	Pfam Transposase IS66
HRR27_RS05025	COG4372	Transposase
HRR27_RS05040	COG2433	Pfam Transposase IS66
HRR27_RS05055	COG2433	Pfam Transposase IS66
HRR27_RS05070	COG4372	Transposase
HRR27_RS05085	COG3436	PFAM IS66 Orf2 family protein
HRR27_RS05090	COG4372	Transposase
HRR27_RS05110	COG4372	Transposase
HRR27_RS05115	COG3436	PFAM IS66 Orf2 family protein
HRR27_RS05130	COG4372	Transposase
HRR27_RS05140	COG2433	Pfam Transposase IS66
HRR27_RS05170	COG0205	6-phosphofructokinase activity
HRR27_RS05175	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HRR27_RS05180	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HRR27_RS05200	COG2433	Pfam Transposase IS66
HRR27_RS05210	COG3101	peptidyl-lysine hydroxylation
HRR27_RS05220	COG1643	Atp-dependent helicase
HRR27_RS05230	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HRR27_RS05235	COG0352	thiamine-phosphate diphosphorylase activity
HRR27_RS05240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRR27_RS05245	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HRR27_RS05265	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HRR27_RS05275	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HRR27_RS05285	COG0802	atpase or kinase
HRR27_RS05290	COG0860	N-Acetylmuramoyl-L-alanine amidase
HRR27_RS05295	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HRR27_RS05310	COG0006	proline dipeptidase activity
HRR27_RS05315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRR27_RS05320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRR27_RS05325	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HRR27_RS05330	COG0583	DNA-binding transcription factor activity
HRR27_RS05335	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HRR27_RS05340	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HRR27_RS05345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRR27_RS05370	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HRR27_RS05380	COG1177	transmembrane transport
HRR27_RS05385	COG1176	ABC-type spermidine putrescine transport system, permease component I
HRR27_RS05390	COG3842	ATPase activity
HRR27_RS05395	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HRR27_RS05400	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRR27_RS05400	COG0493	'glutamate synthase
HRR27_RS05415	COG0488	(ABC) transporter
HRR27_RS05420	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HRR27_RS05425	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HRR27_RS05430	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HRR27_RS05430	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HRR27_RS05445	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HRR27_RS05450	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HRR27_RS05455	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HRR27_RS05460	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HRR27_RS05470	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HRR27_RS05475	COG0720	synthase
HRR27_RS05480	COG0142	geranyltranstransferase activity
HRR27_RS05495	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HRR27_RS05500	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HRR27_RS05505	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HRR27_RS05510	COG0632	four-way junction helicase activity
HRR27_RS05515	COG2255	four-way junction helicase activity
HRR27_RS05520	COG0811	peptide transport
HRR27_RS05535	COG0823	Involved in the tonB-independent uptake of proteins
HRR27_RS05540	COG2885	chlorophyll binding
HRR27_RS05550	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HRR27_RS05575	COG3852	Histidine kinase
HRR27_RS05580	COG2204	response regulator
HRR27_RS05590	COG1238	metal cluster binding
HRR27_RS05600	COG0688	phosphatidylethanolamine metabolic process
HRR27_RS05605	COG0137	argininosuccinate synthase activity
HRR27_RS05610	COG1278	Cold shock
HRR27_RS05620	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HRR27_RS05630	COG1301	dicarboxylic acid transport
HRR27_RS05635	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRR27_RS05650	COG0215	cysteine-tRNA ligase activity
HRR27_RS05660	COG0741	lytic transglycosylase activity
HRR27_RS05660	COG1388	LysM domain
HRR27_RS05665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRR27_RS05670	COG2226	methyltransferase
HRR27_RS05675	COG0328	RNA-DNA hybrid ribonuclease activity
HRR27_RS05680	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRR27_RS05685	COG1047	Peptidyl-prolyl cis-trans
HRR27_RS05695	COG1643	Atp-dependent helicase
HRR27_RS05730	COG0045	succinate-CoA ligase (ADP-forming) activity
HRR27_RS05740	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HRR27_RS05740	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRR27_RS05750	COG0564	pseudouridine synthase activity
HRR27_RS05775	COG0716	FMN binding
HRR27_RS05785	COG1051	belongs to the nudix hydrolase family
HRR27_RS05795	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRR27_RS05800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRR27_RS05820	COG3530	Putative quorum-sensing-regulated virulence factor
HRR27_RS05825	COG0686	Belongs to the AlaDH PNT family
HRR27_RS05845	COG1902	pentaerythritol trinitrate reductase activity
HRR27_RS05850	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HRR27_RS05860	COG0596	Alpha beta hydrolase
HRR27_RS05870	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HRR27_RS05875	COG0513	Belongs to the DEAD box helicase family
HRR27_RS05885	COG3122	Protein conserved in bacteria
HRR27_RS05895	COG0513	Belongs to the DEAD box helicase family
HRR27_RS05900	COG0488	(ABC) transporter
HRR27_RS05920	COG1192	Involved in chromosome partitioning
HRR27_RS05935	COG0545	Peptidyl-prolyl cis-trans isomerase
HRR27_RS05950	COG3094	Invasion gene expression up-regulator, SirB
HRR27_RS05970	COG0564	pseudouridine synthase activity
HRR27_RS05975	COG2983	Belongs to the UPF0260 family
HRR27_RS05985	COG1047	Peptidyl-prolyl cis-trans
HRR27_RS06020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRR27_RS06045	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRR27_RS06070	COG0840	transmembrane signaling receptor activity
HRR27_RS06085	COG2954	triphosphatase activity
HRR27_RS06095	COG0747	negative chemotaxis
HRR27_RS06105	COG0601	transmembrane transport
HRR27_RS06120	COG1472	Belongs to the glycosyl hydrolase 3 family
HRR27_RS06125	COG0668	transmembrane transport
HRR27_RS06135	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HRR27_RS06140	COG0733	neurotransmitter:sodium symporter activity
HRR27_RS06160	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HRR27_RS06175	COG2022	thiamine diphosphate biosynthetic process
HRR27_RS06200	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HRR27_RS06210	COG0446	pyridine nucleotide-disulphide oxidoreductase
HRR27_RS06230	COG1136	(ABC) transporter
HRR27_RS06235	COG0488	(ABC) transporter
HRR27_RS06240	COG0616	signal peptide processing
HRR27_RS06245	COG0322	excinuclease ABC activity
HRR27_RS06375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HRR27_RS06380	COG1393	Belongs to the ArsC family
HRR27_RS06385	COG2171	N-acyltransferase activity
HRR27_RS06395	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HRR27_RS06400	COG0024	Methionine aminopeptidase
HRR27_RS06405	COG0052	Belongs to the universal ribosomal protein uS2 family
HRR27_RS06410	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HRR27_RS06415	COG0528	UMP kinase activity
HRR27_RS06420	COG0233	cytoplasmic translational termination
HRR27_RS06430	COG0575	Belongs to the CDS family
HRR27_RS06440	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HRR27_RS06450	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRR27_RS06455	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HRR27_RS06460	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRR27_RS06465	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRR27_RS06470	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HRR27_RS06475	COG0835	chemotaxis
HRR27_RS06475	COG0784	Response regulator, receiver
HRR27_RS06495	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HRR27_RS06500	COG1199	ATP-dependent helicase activity
HRR27_RS06525	COG1944	ATP diphosphatase activity
HRR27_RS06535	COG0825	malonyl-CoA metabolic process
HRR27_RS06540	COG0037	tRNA processing
HRR27_RS06545	COG0504	CTP synthase activity
HRR27_RS06550	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HRR27_RS06555	COG0148	phosphopyruvate hydratase activity
HRR27_RS06560	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HRR27_RS06570	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HRR27_RS06575	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HRR27_RS06580	COG1238	metal cluster binding
HRR27_RS06595	COG0436	Aminotransferase
HRR27_RS06610	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HRR27_RS06645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRR27_RS06655	COG1070	Carbohydrate kinase
HRR27_RS06665	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HRR27_RS06670	COG3028	Belongs to the UPF0307 family
HRR27_RS06685	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HRR27_RS06690	COG2350	Protein conserved in bacteria
HRR27_RS06695	COG2917	probably involved in intracellular septation
HRR27_RS06700	COG0613	PHP domain protein
HRR27_RS06705	COG0009	L-threonylcarbamoyladenylate synthase
HRR27_RS06710	COG1994	Peptidase M50
HRR27_RS06715	COG1187	pseudouridine synthase activity
HRR27_RS06750	COG1570	exodeoxyribonuclease VII activity
HRR27_RS06760	COG3706	GGDEF domain
HRR27_RS06770	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HRR27_RS06805	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HRR27_RS06835	COG0745	RESPONSE REGULATOR receiver
HRR27_RS06850	COG3012	SEC-C Motif Domain Protein
HRR27_RS06855	COG0534	Mate efflux family protein
HRR27_RS06865	COG0494	nUDIX hydrolase
HRR27_RS06870	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HRR27_RS06880	COG0359	binds to the 23S rRNA
HRR27_RS06890	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HRR27_RS06895	COG0360	Binds together with S18 to 16S ribosomal RNA
HRR27_RS06900	COG0284	orotidine-5'-phosphate decarboxylase activity
HRR27_RS06910	COG0776	regulation of translation
HRR27_RS06920	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HRR27_RS06925	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HRR27_RS06930	COG0287	Prephenate dehydrogenase
HRR27_RS06935	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRR27_RS06940	COG0077	Prephenate dehydratase
HRR27_RS06940	COG1605	Chorismate mutase
HRR27_RS06945	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HRR27_RS06955	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HRR27_RS06965	COG1028	Short-chain dehydrogenase reductase Sdr
HRR27_RS06980	COG0601	transmembrane transport
HRR27_RS06985	COG0747	negative chemotaxis
HRR27_RS07030	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HRR27_RS07035	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HRR27_RS07040	COG0740	serine-type endopeptidase activity
HRR27_RS07045	COG0544	peptidyl-prolyl cis-trans isomerase activity
HRR27_RS07050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HRR27_RS07090	COG1131	(ABC) transporter
HRR27_RS07095	COG0842	Transport permease protein
HRR27_RS07100	COG2850	peptidyl-arginine hydroxylation
HRR27_RS07105	COG3118	belongs to the thioredoxin family
HRR27_RS07115	COG1185	polyribonucleotide nucleotidyltransferase activity
HRR27_RS07120	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HRR27_RS07130	COG0500	methyltransferase
HRR27_RS07135	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HRR27_RS07140	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HRR27_RS07145	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HRR27_RS07150	COG0195	Participates in both transcription termination and antitermination
HRR27_RS07155	COG0779	Required for maturation of 30S ribosomal subunits
HRR27_RS07160	COG2176	DNA-directed DNA polymerase activity
HRR27_RS07170	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HRR27_RS07180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HRR27_RS07190	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HRR27_RS07210	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HRR27_RS07220	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HRR27_RS07230	COG0542	response to heat
HRR27_RS07235	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HRR27_RS07245	COG2824	Alkylphosphonate utilization operon protein PhnA
HRR27_RS07250	COG0217	transcriptional regulatory protein
HRR27_RS07275	COG0482	sulfurtransferase activity
HRR27_RS07280	COG2915	High frequency lysogenization protein hflD homolog
HRR27_RS07290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HRR27_RS07300	COG0745	RESPONSE REGULATOR receiver
HRR27_RS07315	COG2433	Pfam Transposase IS66
HRR27_RS07320	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HRR27_RS07325	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HRR27_RS07330	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HRR27_RS07335	COG0330	HflC and HflK could
HRR27_RS07340	COG0330	HflC and HflK could
HRR27_RS07345	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HRR27_RS07350	COG1923	regulation of RNA biosynthetic process
HRR27_RS07355	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HRR27_RS07365	COG0489	protein tyrosine kinase activity
HRR27_RS07370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRR27_RS07370	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRR27_RS07375	COG4657	Part of a membrane complex involved in electron transport
HRR27_RS07380	COG2878	Part of a membrane complex involved in electron transport
HRR27_RS07385	COG4656	Part of a membrane complex involved in electron transport
HRR27_RS07400	COG4660	Part of a membrane complex involved in electron transport
HRR27_RS07410	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HRR27_RS07425	COG1280	lysine exporter protein (LysE YggA)
HRR27_RS07435	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HRR27_RS07445	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HRR27_RS07445	COG0519	Catalyzes the synthesis of GMP from XMP
HRR27_RS07455	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HRR27_RS07465	COG4206	TonB-dependent receptor
HRR27_RS07470	COG1492	cobalamin metabolic process
HRR27_RS07485	COG3002	Belongs to the UPF0753 family
HRR27_RS07490	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HRR27_RS07495	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HRR27_RS07495	COG3264	Mechanosensitive ion channel
HRR27_RS07510	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HRR27_RS07515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HRR27_RS07520	COG2814	Major facilitator Superfamily
HRR27_RS07530	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HRR27_RS07535	COG2835	tetraacyldisaccharide 4'-kinase activity
HRR27_RS07540	COG1663	tetraacyldisaccharide 4'-kinase activity
HRR27_RS07545	COG2333	competence protein COMEC
HRR27_RS07545	COG0658	competence protein
HRR27_RS07555	COG1067	ATP-dependent peptidase activity
HRR27_RS07560	COG0004	ammonium transporteR
HRR27_RS07600	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HRR27_RS07625	COG0736	holo-[acyl-carrier-protein] synthase activity
HRR27_RS07630	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HRR27_RS07640	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HRR27_RS07645	COG0571	ribonuclease III activity
HRR27_RS07655	COG0481	GTPase activity
HRR27_RS07660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRR27_RS07675	COG0835	chemotaxis
HRR27_RS07700	COG1216	Glycosyl transferase, family 2
HRR27_RS07700	COG0438	transferase activity, transferring glycosyl groups
HRR27_RS07720	COG2433	Pfam Transposase IS66
HRR27_RS07755	COG4372	Transposase
HRR27_RS07825	COG2433	Pfam Transposase IS66
HRR27_RS07835	COG2433	Pfam Transposase IS66
HRR27_RS07840	COG2433	Pfam Transposase IS66
HRR27_RS07895	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HRR27_RS07895	COG2124	cytochrome p450
HRR27_RS07905	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HRR27_RS07920	COG2197	response regulator
HRR27_RS07930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRR27_RS07935	COG0300	oxidoreductase activity
HRR27_RS07940	COG0746	molybdenum cofactor guanylyltransferase activity
HRR27_RS07945	COG0303	'Molybdopterin
HRR27_RS07950	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HRR27_RS07955	COG1648	precorrin-2 dehydrogenase activity
HRR27_RS07955	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HRR27_RS07960	COG0243	molybdopterin cofactor binding
HRR27_RS07965	COG2146	nitrite reductase [NAD(P)H] activity
HRR27_RS07970	COG0515	serine threonine protein kinase
HRR27_RS07975	COG2223	nitrite transmembrane transporter activity
HRR27_RS07990	COG1595	DNA-templated transcription, initiation
HRR27_RS08000	COG1187	pseudouridine synthase activity
HRR27_RS08010	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HRR27_RS08020	COG0442	prolyl-tRNA aminoacylation
HRR27_RS08030	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HRR27_RS08045	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HRR27_RS08065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRR27_RS08080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRR27_RS08085	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HRR27_RS08095	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HRR27_RS08100	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HRR27_RS08110	COG0717	Belongs to the dCTP deaminase family
HRR27_RS08115	COG0189	ligase activity
HRR27_RS08120	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HRR27_RS08125	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HRR27_RS08130	COG1116	anion transmembrane transporter activity
HRR27_RS08140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HRR27_RS08140	COG1116	anion transmembrane transporter activity
HRR27_RS08155	COG1940	carbohydrate kinase activity
HRR27_RS08160	COG2833	Protein of unknown function (DUF455)
HRR27_RS08175	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HRR27_RS08185	COG0505	Belongs to the CarA family
HRR27_RS08190	COG0791	NLP P60 protein
HRR27_RS08195	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HRR27_RS08200	COG0484	heat shock protein binding
HRR27_RS08205	COG0443	Heat shock 70 kDa protein
HRR27_RS08210	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HRR27_RS08215	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HRR27_RS08220	COG0497	DNA recombination
HRR27_RS08225	COG0735	belongs to the Fur family
HRR27_RS08250	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HRR27_RS08255	COG3706	GGDEF domain
HRR27_RS08265	COG3706	GGDEF domain
HRR27_RS08290	COG0084	hydrolase, TatD family'
HRR27_RS08295	COG0470	DNA polymerase III
HRR27_RS08300	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HRR27_RS08305	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HRR27_RS08310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HRR27_RS08315	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HRR27_RS08320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRR27_RS08325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HRR27_RS08330	COG1028	Short-chain dehydrogenase reductase Sdr
HRR27_RS08335	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HRR27_RS08340	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HRR27_RS08345	COG0416	fatty acid biosynthetic process
HRR27_RS08350	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HRR27_RS08360	COG0424	maF-like protein
HRR27_RS08365	COG0546	phosphoglycolate phosphatase activity
HRR27_RS08370	COG0564	pseudouridine synthase activity
HRR27_RS08375	COG1530	ribonuclease E activity
HRR27_RS08380	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HRR27_RS08400	COG0582	viral genome integration into host DNA
HRR27_RS08655	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HRR27_RS08730	COG2894	cell division
HRR27_RS08755	COG0210	DNA helicase
HRR27_RS08765	COG1007	ATP synthesis coupled electron transport
HRR27_RS08780	COG0713	ATP synthesis coupled electron transport
HRR27_RS08790	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRR27_RS08795	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HRR27_RS08800	COG1034	ATP synthesis coupled electron transport
HRR27_RS08815	COG0649	NAD binding
HRR27_RS08820	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRR27_RS08825	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRR27_RS08830	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRR27_RS08845	COG0149	triose-phosphate isomerase activity
HRR27_RS08850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HRR27_RS08855	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HRR27_RS08865	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HRR27_RS08870	COG1534	Rna-binding protein
HRR27_RS08890	COG0285	dihydrofolate synthase activity
HRR27_RS08895	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HRR27_RS08900	COG0159	tryptophan synthase activity
HRR27_RS08910	COG0135	phosphoribosylanthranilate isomerase activity
HRR27_RS08915	COG0101	tRNA pseudouridine synthase activity
HRR27_RS08920	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HRR27_RS08930	COG0739	heme binding
HRR27_RS08935	COG0473	3-isopropylmalate dehydrogenase activity
HRR27_RS08940	COG0066	3-isopropylmalate dehydratase activity
HRR27_RS08945	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HRR27_RS08950	COG0602	queuosine metabolic process
HRR27_RS08955	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HRR27_RS08960	COG0583	DNA-binding transcription factor activity
HRR27_RS08965	COG0583	DNA-binding transcription factor activity
HRR27_RS08970	COG0730	response to heat
HRR27_RS08980	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HRR27_RS08990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HRR27_RS08995	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HRR27_RS09010	COG0803	Belongs to the bacterial solute-binding protein 9 family
HRR27_RS09015	COG1121	(ABC) transporter
HRR27_RS09020	COG1321	iron dependent repressor
HRR27_RS09020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRR27_RS09025	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRR27_RS09040	COG0659	secondary active sulfate transmembrane transporter activity
HRR27_RS09050	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRR27_RS09055	COG1518	maintenance of DNA repeat elements
HRR27_RS09065	COG1857	crispr-associated protein
HRR27_RS09100	COG3123	guanosine phosphorylase activity
HRR27_RS09115	COG0735	belongs to the Fur family
HRR27_RS09120	COG2814	Major facilitator Superfamily
HRR27_RS09125	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HRR27_RS09135	COG3338	carbonate dehydratase activity
HRR27_RS09140	COG2890	protein-(glutamine-N5) methyltransferase activity
HRR27_RS09145	COG0521	Mo-molybdopterin cofactor biosynthetic process
HRR27_RS09150	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HRR27_RS09165	COG4181	ATPase activity
HRR27_RS09170	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HRR27_RS09205	COG0776	regulation of translation
HRR27_RS09210	COG0072	phenylalanine-tRNA ligase activity
HRR27_RS09210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRR27_RS09215	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HRR27_RS09220	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HRR27_RS09225	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HRR27_RS09230	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HRR27_RS09235	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HRR27_RS09245	COG4771	TonB-dependent receptor
HRR27_RS09265	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HRR27_RS09285	COG0446	pyridine nucleotide-disulphide oxidoreductase
HRR27_RS09290	COG2863	cytochrome
HRR27_RS09300	COG3608	succinylglutamate desuccinylase aspartoacylase
HRR27_RS09305	COG0189	ligase activity
HRR27_RS09320	COG2199	diguanylate cyclase activity
HRR27_RS09320	COG2200	EAL domain
HRR27_RS09325	COG0679	Auxin Efflux Carrier
HRR27_RS09360	COG2433	Pfam Transposase IS66
HRR27_RS09365	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HRR27_RS09365	COG2755	lipolytic protein G-D-S-L family
HRR27_RS09370	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HRR27_RS09380	COG0028	Belongs to the TPP enzyme family
HRR27_RS09385	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HRR27_RS09390	COG0501	Belongs to the peptidase M48B family
HRR27_RS09395	COG2154	pterin-4-alpha-carbinolamine dehydratase
HRR27_RS09400	COG1162	GTPase activity
HRR27_RS09425	COG1160	GTP binding
HRR27_RS09440	COG0124	histidyl-tRNA synthetase
HRR27_RS09450	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HRR27_RS09455	COG0105	UTP biosynthetic process
HRR27_RS09465	COG1959	2 iron, 2 sulfur cluster binding
HRR27_RS09485	COG0456	acetyltransferase
HRR27_RS09495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HRR27_RS09500	COG1183	phosphatidylcholine synthase activity
HRR27_RS09505	COG2210	Belongs to the sulfur carrier protein TusA family
HRR27_RS09515	COG4783	chaperone-mediated protein folding
HRR27_RS09535	COG3258	Cytochrome c
HRR27_RS09545	COG0129	dihydroxy-acid dehydratase activity
HRR27_RS09555	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRR27_RS09560	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HRR27_RS09565	COG0367	asparagine synthase
HRR27_RS09575	COG0247	lactate metabolic process
HRR27_RS09580	COG0277	FAD linked oxidase domain protein
HRR27_RS09585	COG0277	FAD linked oxidase domain protein
HRR27_RS09590	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HRR27_RS09595	COG4221	oxidoreductase activity
HRR27_RS09600	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HRR27_RS09605	COG0352	thiamine-phosphate diphosphorylase activity
HRR27_RS09610	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRR27_RS09615	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HRR27_RS09620	COG0653	protein targeting
HRR27_RS09630	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HRR27_RS09640	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HRR27_RS09645	COG1181	Belongs to the D-alanine--D-alanine ligase family
HRR27_RS09650	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HRR27_RS09660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HRR27_RS09665	COG0719	Fe-S assembly protein
HRR27_RS09670	COG0396	ATPase activity
HRR27_RS09675	COG0719	Fe-S assembly protein
HRR27_RS09685	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HRR27_RS09690	COG1121	(ABC) transporter
HRR27_RS09695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRR27_RS09700	COG0840	transmembrane signaling receptor activity
HRR27_RS09705	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HRR27_RS09715	COG4149	molybdate abc transporter
HRR27_RS09730	COG3585	molybdate ion transport
HRR27_RS09740	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HRR27_RS09760	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HRR27_RS09770	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HRR27_RS09775	COG0772	Belongs to the SEDS family
HRR27_RS09780	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HRR27_RS09785	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HRR27_RS09790	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HRR27_RS09795	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HRR27_RS09815	COG0275	rRNA processing
HRR27_RS09845	COG0742	ribosomal rna small subunit methyltransferase
HRR27_RS09855	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HRR27_RS09860	COG3107	peptidoglycan biosynthetic process
HRR27_RS09865	COG0792	nuclease activity
HRR27_RS09870	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRR27_RS09870	COG0574	Belongs to the PEP-utilizing enzyme family
HRR27_RS09875	COG4106	trans-aconitate 2-methyltransferase activity
HRR27_RS09880	COG1074	ATP-dependent DNA helicase activity
HRR27_RS09895	COG1278	Cold shock
HRR27_RS09900	COG1278	Cold shock
HRR27_RS09910	COG0564	pseudouridine synthase activity
HRR27_RS09925	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HRR27_RS09930	COG3038	cytochrome b561
HRR27_RS09940	COG0501	Belongs to the peptidase M48B family
HRR27_RS09945	COG1704	LemA family
HRR27_RS09955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HRR27_RS09965	COG1304	FMN binding
HRR27_RS09970	COG3425	synthase
HRR27_RS09990	COG2969	positive regulation of protein catabolic process
HRR27_RS09995	COG0625	glutathione transferase activity
HRR27_RS10005	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HRR27_RS10010	COG1509	lysine 2,3-aminomutase activity
HRR27_RS10025	COG1322	Protein conserved in bacteria
HRR27_RS10060	COG1450	Type ii and iii secretion system protein
HRR27_RS10065	COG3267	Type II secretory pathway component ExeA
HRR27_RS10065	COG3409	Peptidoglycan-binding domain 1 protein
HRR27_RS10100	COG1530	ribonuclease E activity
HRR27_RS10105	COG0424	maF-like protein
HRR27_RS10120	COG0463	Glycosyl transferase, family 2
HRR27_RS10150	COG0859	PFAM glycosyl transferase family 9
HRR27_RS10160	COG1132	(ABC) transporter
HRR27_RS10165	COG1560	Kdo2-lipid A biosynthetic process
HRR27_RS10170	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HRR27_RS10170	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HRR27_RS10175	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HRR27_RS10190	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HRR27_RS10195	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HRR27_RS10205	COG2433	Pfam Transposase IS66
HRR27_RS10240	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HRR27_RS10245	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HRR27_RS10250	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HRR27_RS10295	COG4964	Belongs to the GSP D family
HRR27_RS10335	COG2945	thiolester hydrolase activity
HRR27_RS10340	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HRR27_RS10370	COG4232	protein-disulfide reductase activity
HRR27_RS10375	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HRR27_RS10380	COG0511	ligase activity, forming carbon-carbon bonds
HRR27_RS10385	COG0439	Biotin carboxylase
HRR27_RS10390	COG2264	protein methyltransferase activity
HRR27_RS10395	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HRR27_RS10400	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HRR27_RS10405	COG0138	bifunctional purine biosynthesis protein purh
HRR27_RS10410	COG0151	Belongs to the GarS family
HRR27_RS10420	COG4133	protoheme IX ABC transporter activity
HRR27_RS10430	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HRR27_RS10435	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HRR27_RS10440	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HRR27_RS10445	COG1138	Cytochrome C-type biogenesis protein
HRR27_RS10450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRR27_RS10465	COG3005	denitrification pathway
HRR27_RS10470	COG2863	cytochrome
HRR27_RS10475	COG0446	pyridine nucleotide-disulphide oxidoreductase
HRR27_RS10480	COG0446	pyridine nucleotide-disulphide oxidoreductase
HRR27_RS10495	COG0446	pyridine nucleotide-disulphide oxidoreductase
HRR27_RS10500	COG0542	response to heat
HRR27_RS10520	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HRR27_RS10520	COG0116	Belongs to the methyltransferase superfamily
HRR27_RS10525	COG2951	lytic endotransglycosylase activity
HRR27_RS10540	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HRR27_RS10545	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HRR27_RS10550	COG0196	riboflavin kinase activity
HRR27_RS10565	COG0028	Belongs to the TPP enzyme family
HRR27_RS10570	COG0268	Binds directly to 16S ribosomal RNA
HRR27_RS10585	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HRR27_RS10590	COG0799	negative regulation of ribosome biogenesis
HRR27_RS10595	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HRR27_RS10600	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HRR27_RS10615	COG0495	leucyl-tRNA aminoacylation
HRR27_RS10625	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HRR27_RS10630	COG4535	Mg2 and Co2 transporter CorC
HRR27_RS10635	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HRR27_RS10640	COG1702	phosphate starvation-inducible protein PhoH
HRR27_RS10645	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRR27_RS10655	COG3852	Histidine kinase
HRR27_RS10660	COG0745	RESPONSE REGULATOR receiver
HRR27_RS10680	COG2165	general secretion pathway protein
HRR27_RS10695	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HRR27_RS10700	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HRR27_RS10720	COG1610	YqeY-like protein
HRR27_RS10725	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HRR27_RS10730	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HRR27_RS10735	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HRR27_RS10740	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HRR27_RS10760	COG1968	undecaprenyl-diphosphatase activity
HRR27_RS10770	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HRR27_RS10770	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HRR27_RS10780	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HRR27_RS10790	COG5001	Diguanylate cyclase
HRR27_RS10790	COG5002	protein histidine kinase activity
HRR27_RS10795	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HRR27_RS10800	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HRR27_RS10805	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HRR27_RS10815	COG0189	ligase activity
HRR27_RS10825	COG1678	Uncharacterized ACR, COG1678
HRR27_RS10830	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HRR27_RS10835	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HRR27_RS10840	COG0540	Belongs to the ATCase OTCase family
HRR27_RS10845	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HRR27_RS10860	COG2326	polyphosphate kinase activity
HRR27_RS10880	COG0762	integral membrane protein
HRR27_RS10885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HRR27_RS10900	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HRR27_RS10915	COG0748	coenzyme F420 binding
HRR27_RS10920	COG0400	carboxylic ester hydrolase activity
HRR27_RS10930	COG0019	diaminopimelate decarboxylase activity
HRR27_RS10945	COG0509	glycine decarboxylation via glycine cleavage system
HRR27_RS10955	COG1366	Belongs to the anti-sigma-factor antagonist family
HRR27_RS10960	COG0789	Transcriptional regulator
HRR27_RS10965	COG0415	Belongs to the DNA photolyase family
HRR27_RS10995	COG0300	oxidoreductase activity
HRR27_RS11010	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HRR27_RS11015	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HRR27_RS11020	COG2205	protein histidine kinase activity
HRR27_RS11020	COG3437	response regulator, receiver
HRR27_RS11020	COG3850	Histidine kinase
HRR27_RS11020	COG4999	Histidine kinase
HRR27_RS11025	COG2433	Pfam Transposase IS66
HRR27_RS11060	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HRR27_RS11070	COG0316	Belongs to the HesB IscA family
HRR27_RS11075	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HRR27_RS11080	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HRR27_RS11085	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HRR27_RS11095	COG0459	protein refolding
HRR27_RS11100	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HRR27_RS11105	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HRR27_RS11110	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HRR27_RS11115	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HRR27_RS11120	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HRR27_RS11125	COG0142	geranyltranstransferase activity
HRR27_RS11135	COG0629	single-stranded DNA binding
HRR27_RS11140	COG2814	Major facilitator Superfamily
HRR27_RS11160	COG0837	glucose binding
HRR27_RS11165	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HRR27_RS11175	COG0203	ribosomal protein L17
HRR27_RS11180	COG0202	RNA polymerase activity
HRR27_RS11185	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HRR27_RS11190	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HRR27_RS11195	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HRR27_RS11200	COG0201	protein transport
HRR27_RS11205	COG0200	Binds to the 23S rRNA
HRR27_RS11210	COG1841	ribosomal large subunit assembly
HRR27_RS11215	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HRR27_RS11220	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HRR27_RS11225	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HRR27_RS11230	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HRR27_RS11235	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HRR27_RS11240	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HRR27_RS11245	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HRR27_RS11250	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HRR27_RS11255	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HRR27_RS11260	COG0255	Belongs to the universal ribosomal protein uL29 family
HRR27_RS11265	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HRR27_RS11270	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HRR27_RS11275	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HRR27_RS11280	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HRR27_RS11285	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HRR27_RS11290	COG0089	rRNA binding
HRR27_RS11295	COG0088	Forms part of the polypeptide exit tunnel
HRR27_RS11300	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HRR27_RS11305	COG0051	transcription antitermination factor activity, RNA binding
HRR27_RS11310	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HRR27_RS11315	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HRR27_RS11320	COG0049	tRNA binding
HRR27_RS11325	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HRR27_RS11330	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HRR27_RS11335	COG0085	RNA polymerase activity
HRR27_RS11340	COG0222	ribosome binding
HRR27_RS11345	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HRR27_RS11350	COG0081	regulation of translation
HRR27_RS11355	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HRR27_RS11365	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HRR27_RS11375	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HRR27_RS11400	COG0564	pseudouridine synthase activity
HRR27_RS11405	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HRR27_RS11430	COG1012	belongs to the aldehyde dehydrogenase family
HRR27_RS11445	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HRR27_RS11460	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HRR27_RS11475	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HRR27_RS11480	COG0588	phosphoglycerate mutase activity
HRR27_RS11495	COG0668	transmembrane transport
HRR27_RS11500	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HRR27_RS11505	COG1666	GTP binding
HRR27_RS11510	COG0436	Aminotransferase
HRR27_RS11535	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HRR27_RS11540	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HRR27_RS11550	COG0356	it plays a direct role in the translocation of protons across the membrane
HRR27_RS11560	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HRR27_RS11560	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HRR27_RS11575	COG0756	dUTP diphosphatase activity
HRR27_RS11585	COG0033	Phosphoglucomutase
HRR27_RS11600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HRR27_RS11605	COG0590	tRNA wobble adenosine to inosine editing
HRR27_RS11615	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HRR27_RS11630	COG0446	pyridine nucleotide-disulphide oxidoreductase
HRR27_RS11645	COG2003	Belongs to the UPF0758 family
HRR27_RS11665	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HRR27_RS11670	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HRR27_RS11685	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HRR27_RS11695	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HRR27_RS11725	COG0450	alkyl hydroperoxide reductase
HRR27_RS11730	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HRR27_RS11735	COG0742	ribosomal rna small subunit methyltransferase
HRR27_RS11740	COG0583	DNA-binding transcription factor activity
HRR27_RS11745	COG5002	protein histidine kinase activity
HRR27_RS11745	COG2205	protein histidine kinase activity
HRR27_RS11745	COG0784	Response regulator, receiver
HRR27_RS11755	COG0612	Peptidase, M16
HRR27_RS11760	COG0612	Peptidase, M16
HRR27_RS11765	COG0552	protein localization to endoplasmic reticulum
HRR27_RS11785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HRR27_RS11795	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HRR27_RS11830	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HRR27_RS11835	COG0167	dihydroorotate dehydrogenase activity
HRR27_RS11840	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HRR27_RS11845	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HRR27_RS11850	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HRR27_RS11865	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HRR27_RS11870	COG0067	glutamate synthase
HRR27_RS11870	COG0069	glutamate synthase activity
HRR27_RS11870	COG0070	glutamate synthase
HRR27_RS11875	COG0493	'glutamate synthase
HRR27_RS11890	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HRR27_RS11900	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HRR27_RS11920	COG4771	TonB-dependent receptor
HRR27_RS11930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRR27_RS11940	COG4619	ABC transporter
HRR27_RS11945	COG0210	DNA helicase
HRR27_RS11960	COG0254	rRNA binding
HRR27_RS11970	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HRR27_RS11980	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HRR27_RS11985	COG1194	a g-specific adenine glycosylase
HRR27_RS11990	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HRR27_RS12000	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HRR27_RS12005	COG2814	Major facilitator Superfamily
HRR27_RS12010	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HRR27_RS12015	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HRR27_RS12020	COG1561	YicC-like family, N-terminal region
HRR27_RS12030	COG3550	peptidyl-serine autophosphorylation
HRR27_RS12035	COG3620	sequence-specific DNA binding
HRR27_RS12100	COG3001	Fructosamine kinase
HRR27_RS12105	COG0563	adenylate kinase activity
HRR27_RS12130	COG2205	protein histidine kinase activity
HRR27_RS12135	COG0745	RESPONSE REGULATOR receiver
HRR27_RS12140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRR27_RS12145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRR27_RS12150	COG3706	GGDEF domain
HRR27_RS12175	COG4372	Transposase
HRR27_RS12195	COG4372	Transposase
HRR27_RS12210	COG1429	ligase activity, forming nitrogen-metal bonds
HRR27_RS12215	COG4771	TonB-dependent receptor
HRR27_RS12220	COG1429	ligase activity, forming nitrogen-metal bonds
HRR27_RS12235	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HRR27_RS12240	COG1854	S-ribosylhomocysteine lyase activity
HRR27_RS12250	COG3046	protein related to deoxyribodipyrimidine photolyase
HRR27_RS12255	COG2176	DNA-directed DNA polymerase activity
HRR27_RS12265	COG0415	Belongs to the DNA photolyase family
HRR27_RS12280	COG0259	pyridoxamine-phosphate oxidase activity
HRR27_RS12285	COG0745	RESPONSE REGULATOR receiver
HRR27_RS12290	COG3437	response regulator, receiver
HRR27_RS12290	COG4999	Histidine kinase
HRR27_RS12290	COG3850	Histidine kinase
HRR27_RS12290	COG2205	protein histidine kinase activity
HRR27_RS12300	COG1741	Belongs to the pirin family
HRR27_RS12305	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HRR27_RS12315	COG0840	transmembrane signaling receptor activity
HRR27_RS12315	COG0840	transmembrane signaling receptor activity
HRR27_RS12320	COG0330	HflC and HflK could
HRR27_RS12380	COG0840	transmembrane signaling receptor activity
HRR27_RS12400	COG0583	DNA-binding transcription factor activity
HRR27_RS12410	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HRR27_RS12475	COG1850	ribulose-bisphosphate carboxylase activity
HRR27_RS12485	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HRR27_RS12500	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HRR27_RS12505	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HRR27_RS12520	COG0676	glucose-6-phosphate 1-epimerase activity
HRR27_RS12525	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HRR27_RS12530	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HRR27_RS12535	COG0194	GDP metabolic process
HRR27_RS12540	COG1758	RNA polymerase activity
HRR27_RS12545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HRR27_RS12555	COG0561	phosphatase activity
HRR27_RS12560	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HRR27_RS12565	COG3161	chorismate lyase activity
HRR27_RS12580	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HRR27_RS12590	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HRR27_RS12595	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HRR27_RS12600	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HRR27_RS12610	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HRR27_RS12615	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HRR27_RS12620	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HRR27_RS12625	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HRR27_RS12630	COG0356	it plays a direct role in the translocation of protons across the membrane
HRR27_RS12650	COG1192	Involved in chromosome partitioning
HRR27_RS12655	COG0357	Ribosomal RNA small subunit methyltransferase G
HRR27_RS12660	COG0445	tRNA wobble uridine modification
HRR27_RS12675	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HRR27_RS12675	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HRR27_RS12715	COG1739	Uncharacterized protein family UPF0029
HRR27_RS12720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRR27_RS12735	COG0840	transmembrane signaling receptor activity
HRR27_RS12745	COG2095	MarC family integral membrane protein
HRR27_RS12750	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HRR27_RS12760	COG0706	membrane insertase activity
HRR27_RS12765	COG0594	ribonuclease P activity
HRR27_RS12770	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HRR27_RS12775	COG0730	response to heat