locus-tag	class	description
TCR_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TCR_RS00010	COG0592	DNA-directed DNA polymerase activity
TCR_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TCR_RS00060	COG0187	DNA topoisomerase II activity
TCR_RS00085	COG0408	coproporphyrinogen oxidase activity
TCR_RS00095	COG0009	L-threonylcarbamoyladenylate synthase
TCR_RS00105	COG3706	GGDEF domain
TCR_RS00115	COG1280	lysine exporter protein (LysE YggA)
TCR_RS00120	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TCR_RS00140	COG0840	transmembrane signaling receptor activity
TCR_RS00145	COG2200	EAL domain
TCR_RS00150	COG0471	metal ion transport
TCR_RS00175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TCR_RS00190	COG1162	GTPase activity
TCR_RS00195	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TCR_RS00200	COG1960	acyl-CoA dehydrogenase activity
TCR_RS00210	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
TCR_RS00225	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
TCR_RS00230	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TCR_RS00230	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TCR_RS00245	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TCR_RS00250	COG1333	cytochrome c biogenesis protein
TCR_RS00255	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TCR_RS00265	COG0028	Belongs to the TPP enzyme family
TCR_RS00275	COG0778	Nitroreductase
TCR_RS00280	COG0583	DNA-binding transcription factor activity
TCR_RS00290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TCR_RS00300	COG1320	monovalent cation:proton antiporter activity
TCR_RS00305	COG2212	antiporter activity
TCR_RS00310	COG1863	multisubunit Na H antiporter MnhE subunit
TCR_RS00315	COG0651	ATP synthesis coupled electron transport
TCR_RS00320	COG1006	Multisubunit Na H antiporter MnhC subunit
TCR_RS00325	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TCR_RS00325	COG2111	Na H antiporter
TCR_RS00330	COG1283	sodium-dependent phosphate transmembrane transporter activity
TCR_RS00345	COG0432	Pfam Uncharacterised protein family UPF0047
TCR_RS00350	COG2205	protein histidine kinase activity
TCR_RS00350	COG4999	Histidine kinase
TCR_RS00350	COG3437	response regulator, receiver
TCR_RS00350	COG3850	Histidine kinase
TCR_RS00355	COG0339	signal peptide processing
TCR_RS00365	COG2814	Major facilitator Superfamily
TCR_RS00380	COG2304	oxidoreductase activity
TCR_RS00400	COG0714	Associated with various cellular activities
TCR_RS00405	COG0840	transmembrane signaling receptor activity
TCR_RS00410	COG0500	methyltransferase
TCR_RS00415	COG2226	methyltransferase
TCR_RS00430	COG5290	Psort location Cytoplasmic, score
TCR_RS00435	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TCR_RS00465	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TCR_RS00470	COG3706	GGDEF domain
TCR_RS00485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TCR_RS00495	COG0714	Associated with various cellular activities
TCR_RS00550	COG0515	serine threonine protein kinase
TCR_RS00550	COG3266	domain, Protein
TCR_RS00560	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TCR_RS00570	COG0165	Argininosuccinate lyase
TCR_RS00580	COG0181	hydroxymethylbilane synthase activity
TCR_RS00605	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TCR_RS00615	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TCR_RS00620	COG1194	a g-specific adenine glycosylase
TCR_RS00625	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
TCR_RS00630	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
TCR_RS00635	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TCR_RS00645	COG0254	rRNA binding
TCR_RS00650	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TCR_RS00660	COG0210	DNA helicase
TCR_RS00665	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TCR_RS00670	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TCR_RS00670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TCR_RS00685	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TCR_RS00690	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TCR_RS00695	COG5002	protein histidine kinase activity
TCR_RS00695	COG2205	protein histidine kinase activity
TCR_RS00695	COG0784	Response regulator, receiver
TCR_RS00705	COG2081	HI0933 family
TCR_RS00715	COG0678	peroxiredoxin activity
TCR_RS00715	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
TCR_RS00735	COG0351	phosphomethylpyrimidine kinase
TCR_RS00740	COG0352	thiamine-phosphate diphosphorylase activity
TCR_RS00745	COG2022	thiamine diphosphate biosynthetic process
TCR_RS00760	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TCR_RS00775	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TCR_RS00785	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TCR_RS00810	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TCR_RS00815	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
TCR_RS00820	COG0314	molybdopterin synthase activity
TCR_RS00825	COG0303	'Molybdopterin
TCR_RS00830	COG0315	cyclic pyranopterin monophosphate synthase activity
TCR_RS00855	COG1490	D-aminoacyl-tRNA deacylase activity
TCR_RS00865	COG1217	gtp-binding protein TYPA
TCR_RS00885	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TCR_RS00905	COG1528	Iron-storage protein
TCR_RS00910	COG0748	coenzyme F420 binding
TCR_RS00915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TCR_RS00920	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TCR_RS00925	COG2258	MOSC domain
TCR_RS00930	COG0037	tRNA processing
TCR_RS00935	COG1560	Kdo2-lipid A biosynthetic process
TCR_RS00940	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TCR_RS00950	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TCR_RS00955	COG0569	domain protein
TCR_RS00960	COG2204	response regulator
TCR_RS00965	COG5000	phosphorelay sensor kinase activity
TCR_RS00975	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TCR_RS00975	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TCR_RS00980	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TCR_RS00985	COG0242	peptide deformylase activity
TCR_RS00990	COG0758	DNA mediated transformation
TCR_RS00995	COG0745	RESPONSE REGULATOR receiver
TCR_RS01000	COG1754	DNA topoisomerase type I activity
TCR_RS01000	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TCR_RS01005	COG5001	Diguanylate cyclase
TCR_RS01010	COG0018	arginyl-trna synthetase
TCR_RS01020	COG2199	diguanylate cyclase activity
TCR_RS01030	COG0606	chelatase, subunit chli
TCR_RS01045	COG2197	response regulator
TCR_RS01060	COG3706	GGDEF domain
TCR_RS01075	COG1454	alcohol dehydrogenase
TCR_RS01085	COG2813	Specifically methylates the guanine in position
TCR_RS01100	COG0585	pseudouridine synthase activity
TCR_RS01105	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TCR_RS01115	COG1473	amidohydrolase
TCR_RS01120	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TCR_RS01125	COG0006	proline dipeptidase activity
TCR_RS01130	COG1012	belongs to the aldehyde dehydrogenase family
TCR_RS01155	COG2203	Gaf domain
TCR_RS01155	COG3706	GGDEF domain
TCR_RS01155	COG4251	negative regulation of phosphorylation
TCR_RS01155	COG5001	Diguanylate cyclase
TCR_RS01205	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TCR_RS01210	COG3100	YcgL domain-containing protein
TCR_RS01220	COG0617	tRNA 3'-terminal CCA addition
TCR_RS01225	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TCR_RS01240	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TCR_RS01245	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TCR_RS01250	COG0126	phosphoglycerate kinase activity
TCR_RS01275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TCR_RS01305	COG3156	type II secretion system protein K
TCR_RS01310	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
TCR_RS01325	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TCR_RS01330	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TCR_RS01340	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TCR_RS01345	COG0546	phosphoglycolate phosphatase activity
TCR_RS01350	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TCR_RS01360	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TCR_RS01365	COG0134	indole-3-glycerol-phosphate synthase activity
TCR_RS01380	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TCR_RS01385	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TCR_RS01390	COG0019	diaminopimelate decarboxylase activity
TCR_RS01395	COG1765	OsmC-like protein
TCR_RS01415	COG0564	pseudouridine synthase activity
TCR_RS01440	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TCR_RS01450	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TCR_RS01460	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TCR_RS01465	COG0081	regulation of translation
TCR_RS01470	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TCR_RS01475	COG0222	ribosome binding
TCR_RS01480	COG0085	RNA polymerase activity
TCR_RS01485	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TCR_RS01490	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TCR_RS01495	COG0049	tRNA binding
TCR_RS01500	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TCR_RS01505	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TCR_RS01510	COG0051	transcription antitermination factor activity, RNA binding
TCR_RS01515	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TCR_RS01520	COG0088	Forms part of the polypeptide exit tunnel
TCR_RS01525	COG0089	rRNA binding
TCR_RS01530	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TCR_RS01535	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TCR_RS01540	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TCR_RS01545	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TCR_RS01550	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TCR_RS01555	COG0255	Belongs to the universal ribosomal protein uL29 family
TCR_RS01560	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TCR_RS01565	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TCR_RS01570	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TCR_RS01575	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TCR_RS01580	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TCR_RS01585	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TCR_RS01590	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TCR_RS01595	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TCR_RS01600	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TCR_RS01605	COG1841	ribosomal large subunit assembly
TCR_RS01610	COG0200	Binds to the 23S rRNA
TCR_RS01615	COG0201	protein transport
TCR_RS01620	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TCR_RS01625	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TCR_RS01630	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TCR_RS01635	COG0202	RNA polymerase activity
TCR_RS01640	COG0203	ribosomal protein L17
TCR_RS01650	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TCR_RS01670	COG2814	Major facilitator Superfamily
TCR_RS01700	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TCR_RS01710	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TCR_RS01740	COG0142	geranyltranstransferase activity
TCR_RS01745	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TCR_RS01750	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TCR_RS01755	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TCR_RS01760	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TCR_RS01765	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TCR_RS01770	COG0459	protein refolding
TCR_RS01780	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TCR_RS01785	COG0316	Belongs to the HesB IscA family
TCR_RS01795	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
TCR_RS01800	COG0739	heme binding
TCR_RS01805	COG0425	Belongs to the sulfur carrier protein TusA family
TCR_RS01815	COG0751	glycine-tRNA ligase activity
TCR_RS01820	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TCR_RS01835	COG1360	Flagellar Motor Protein
TCR_RS01845	COG0840	transmembrane signaling receptor activity
TCR_RS01850	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
TCR_RS01855	COG0259	pyridoxamine-phosphate oxidase activity
TCR_RS01935	COG3706	GGDEF domain
TCR_RS01965	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TCR_RS01970	COG1360	Flagellar Motor Protein
TCR_RS01975	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TCR_RS01980	COG2890	protein-(glutamine-N5) methyltransferase activity
TCR_RS01985	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TCR_RS01990	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TCR_RS02005	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TCR_RS02010	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TCR_RS02015	COG0193	aminoacyl-tRNA hydrolase activity
TCR_RS02045	COG2252	PERMEase
TCR_RS02050	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TCR_RS02060	COG2226	methyltransferase
TCR_RS02070	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TCR_RS02075	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TCR_RS02100	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TCR_RS02110	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TCR_RS02120	COG0542	response to heat
TCR_RS02160	COG0288	reversible hydration of carbon dioxide
TCR_RS02175	COG1850	ribulose-bisphosphate carboxylase activity
TCR_RS02180	COG0583	DNA-binding transcription factor activity
TCR_RS02190	COG1850	ribulose-bisphosphate carboxylase activity
TCR_RS02205	COG4548	von Willebrand factor, type A
TCR_RS02220	COG1136	(ABC) transporter
TCR_RS02250	COG0138	bifunctional purine biosynthesis protein purh
TCR_RS02265	COG2264	protein methyltransferase activity
TCR_RS02270	COG0439	Biotin carboxylase
TCR_RS02275	COG0511	ligase activity, forming carbon-carbon bonds
TCR_RS02280	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TCR_RS02285	COG4232	protein-disulfide reductase activity
TCR_RS02290	COG3030	protein affecting phage T7 exclusion by the F plasmid
TCR_RS02305	COG3439	Domain of unknown function DUF302
TCR_RS02310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TCR_RS02335	COG0523	cobalamin synthesis protein
TCR_RS02355	COG2005	Transcriptional regulator
TCR_RS02360	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TCR_RS02365	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TCR_RS02370	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TCR_RS02405	COG2204	response regulator
TCR_RS02410	COG4191	Histidine kinase
TCR_RS02420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TCR_RS02425	COG1702	phosphate starvation-inducible protein PhoH
TCR_RS02430	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TCR_RS02435	COG4535	Mg2 and Co2 transporter CorC
TCR_RS02440	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TCR_RS02450	COG0495	leucyl-tRNA aminoacylation
TCR_RS02465	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TCR_RS02475	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TCR_RS02480	COG0799	negative regulation of ribosome biogenesis
TCR_RS02485	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TCR_RS02520	COG0268	Binds directly to 16S ribosomal RNA
TCR_RS02530	COG0196	riboflavin kinase activity
TCR_RS02535	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TCR_RS02540	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TCR_RS02550	COG2951	lytic endotransglycosylase activity
TCR_RS02555	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TCR_RS02555	COG0116	Belongs to the methyltransferase superfamily
TCR_RS02560	COG3706	GGDEF domain
TCR_RS02570	COG1519	Transferase
TCR_RS02575	COG0517	IMP dehydrogenase activity
TCR_RS02575	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TCR_RS02585	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TCR_RS02585	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TCR_RS02590	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TCR_RS02595	COG0837	glucose binding
TCR_RS02600	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TCR_RS02615	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TCR_RS02620	COG0297	glycogen (starch) synthase activity
TCR_RS02625	COG0058	SHG alpha-glucan phosphorylase activity
TCR_RS02635	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TCR_RS02650	COG0456	acetyltransferase
TCR_RS02655	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TCR_RS02660	COG1917	Cupin 2, conserved barrel domain protein
TCR_RS02665	COG0527	aspartate kinase activity
TCR_RS02685	COG1566	PFAM secretion protein HlyD family protein
TCR_RS02695	COG1902	pentaerythritol trinitrate reductase activity
TCR_RS02720	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TCR_RS02725	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TCR_RS02730	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TCR_RS02735	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TCR_RS02740	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TCR_RS02755	COG0174	glutamine synthetase
TCR_RS02765	COG0573	inorganic phosphate transmembrane transporter activity
TCR_RS02770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TCR_RS02790	COG0306	phosphate transporter
TCR_RS02825	COG4181	ATPase activity
TCR_RS02830	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
TCR_RS02845	COG0840	transmembrane signaling receptor activity
TCR_RS02845	COG0840	transmembrane signaling receptor activity
TCR_RS02850	COG1643	Atp-dependent helicase
TCR_RS02875	COG2001	Belongs to the MraZ family
TCR_RS02880	COG0275	rRNA processing
TCR_RS02900	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TCR_RS02905	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TCR_RS02910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TCR_RS02915	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TCR_RS02920	COG0772	Belongs to the SEDS family
TCR_RS02925	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TCR_RS02945	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TCR_RS02950	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
TCR_RS02960	COG0840	transmembrane signaling receptor activity
TCR_RS02965	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TCR_RS02970	COG1121	(ABC) transporter
TCR_RS02975	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
TCR_RS02985	COG0719	Fe-S assembly protein
TCR_RS02990	COG0396	ATPase activity
TCR_RS02995	COG0719	Fe-S assembly protein
TCR_RS03000	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TCR_RS03010	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TCR_RS03015	COG1181	Belongs to the D-alanine--D-alanine ligase family
TCR_RS03020	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TCR_RS03030	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TCR_RS03035	COG0653	protein targeting
TCR_RS03045	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TCR_RS03050	COG0352	thiamine-phosphate diphosphorylase activity
TCR_RS03060	COG0237	dephospho-CoA kinase activity
TCR_RS03065	COG0367	asparagine synthase
TCR_RS03075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TCR_RS03080	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TCR_RS03080	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TCR_RS03085	COG0129	dihydroxy-acid dehydratase activity
TCR_RS03095	COG3258	Cytochrome c
TCR_RS03115	COG4783	chaperone-mediated protein folding
TCR_RS03120	COG0425	Belongs to the sulfur carrier protein TusA family
TCR_RS03125	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TCR_RS03130	COG0166	Belongs to the GPI family
TCR_RS03140	COG1183	phosphatidylcholine synthase activity
TCR_RS03145	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TCR_RS03155	COG1214	PFAM Peptidase M22, glycoprotease
TCR_RS03155	COG0456	acetyltransferase
TCR_RS03175	COG1959	2 iron, 2 sulfur cluster binding
TCR_RS03180	COG0316	Belongs to the HesB IscA family
TCR_RS03185	COG0105	UTP biosynthetic process
TCR_RS03190	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TCR_RS03200	COG0124	histidyl-tRNA synthetase
TCR_RS03210	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TCR_RS03215	COG1160	GTP binding
TCR_RS03220	COG0277	FAD linked oxidase domain protein
TCR_RS03220	COG0247	lactate metabolic process
TCR_RS03225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TCR_RS03245	COG1162	GTPase activity
TCR_RS03250	COG2154	pterin-4-alpha-carbinolamine dehydratase
TCR_RS03255	COG0501	Belongs to the peptidase M48B family
TCR_RS03260	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
TCR_RS03265	COG0028	Belongs to the TPP enzyme family
TCR_RS03275	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TCR_RS03280	COG3409	Peptidoglycan-binding domain 1 protein
TCR_RS03280	COG3267	Type II secretory pathway component ExeA
TCR_RS03300	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TCR_RS03305	COG1459	type II secretion system
TCR_RS03325	COG1322	Protein conserved in bacteria
TCR_RS03330	COG0228	four-way junction DNA binding
TCR_RS03335	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TCR_RS03340	COG0336	Belongs to the RNA methyltransferase TrmD family
TCR_RS03345	COG0335	large ribosomal subunit rRNA binding
TCR_RS03350	COG4974	Belongs to the 'phage' integrase family
TCR_RS03355	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TCR_RS03370	COG0564	pseudouridine synthase activity
TCR_RS03375	COG0582	viral genome integration into host DNA
TCR_RS03440	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TCR_RS03540	COG0616	signal peptide processing
TCR_RS03650	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TCR_RS03655	COG1530	ribonuclease E activity
TCR_RS03660	COG0564	pseudouridine synthase activity
TCR_RS03665	COG0546	phosphoglycolate phosphatase activity
TCR_RS03670	COG0424	maF-like protein
TCR_RS03680	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TCR_RS03685	COG0416	fatty acid biosynthetic process
TCR_RS03690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TCR_RS03695	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TCR_RS03700	COG1028	Short-chain dehydrogenase reductase Sdr
TCR_RS03705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TCR_RS03710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TCR_RS03715	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TCR_RS03725	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TCR_RS03730	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TCR_RS03735	COG0470	DNA polymerase III
TCR_RS03740	COG0084	hydrolase, TatD family'
TCR_RS03745	COG1132	(ABC) transporter
TCR_RS03750	COG2217	Heavy metal translocating P-type atpase
TCR_RS03770	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TCR_RS03785	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TCR_RS03790	COG0354	folic acid binding
TCR_RS03795	COG0835	chemotaxis
TCR_RS03800	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TCR_RS03810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TCR_RS03815	COG0481	GTPase activity
TCR_RS03835	COG1381	Involved in DNA repair and RecF pathway recombination
TCR_RS03840	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TCR_RS03845	COG0736	holo-[acyl-carrier-protein] synthase activity
TCR_RS03870	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TCR_RS03900	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
TCR_RS03905	COG0643	Histidine kinase
TCR_RS03905	COG0784	Response regulator, receiver
TCR_RS03905	COG2198	Histidine kinase
TCR_RS03910	COG0835	chemotaxis
TCR_RS03925	COG0745	RESPONSE REGULATOR receiver
TCR_RS03930	COG0835	chemotaxis
TCR_RS03940	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TCR_RS03945	COG2201	protein-glutamate methylesterase activity
TCR_RS03960	COG3323	Protein of unknown function (DUF1653)
TCR_RS03960	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TCR_RS03965	COG0545	Peptidyl-prolyl cis-trans isomerase
TCR_RS03970	COG0492	ferredoxin-NADP+ reductase activity
TCR_RS03980	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TCR_RS03985	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TCR_RS03990	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TCR_RS03995	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TCR_RS04015	COG2200	EAL domain
TCR_RS04015	COG2199	diguanylate cyclase activity
TCR_RS04025	COG3769	mannosylglycerate metabolic process
TCR_RS04030	COG1215	transferase activity, transferring glycosyl groups
TCR_RS04040	COG1929	Belongs to the glycerate kinase type-1 family
TCR_RS04045	COG5002	protein histidine kinase activity
TCR_RS04045	COG5001	Diguanylate cyclase
TCR_RS04050	COG0840	transmembrane signaling receptor activity
TCR_RS04060	COG0513	Belongs to the DEAD box helicase family
TCR_RS04065	COG2353	YceI-like domain
TCR_RS04070	COG3038	cytochrome b561
TCR_RS04075	COG1090	epimerase
TCR_RS04080	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TCR_RS04085	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TCR_RS04090	COG3706	GGDEF domain
TCR_RS04095	COG1959	2 iron, 2 sulfur cluster binding
TCR_RS04105	COG1959	2 iron, 2 sulfur cluster binding
TCR_RS04115	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TCR_RS04135	COG0602	queuosine metabolic process
TCR_RS04140	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TCR_RS04145	COG0066	3-isopropylmalate dehydratase activity
TCR_RS04150	COG0473	3-isopropylmalate dehydrogenase activity
TCR_RS04155	COG0739	heme binding
TCR_RS04165	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TCR_RS04170	COG0101	tRNA pseudouridine synthase activity
TCR_RS04175	COG0135	phosphoribosylanthranilate isomerase activity
TCR_RS04185	COG0159	tryptophan synthase activity
TCR_RS04190	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TCR_RS04195	COG0285	dihydrofolate synthase activity
TCR_RS04215	COG1534	Rna-binding protein
TCR_RS04220	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TCR_RS04230	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TCR_RS04235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TCR_RS04240	COG0149	triose-phosphate isomerase activity
TCR_RS04255	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TCR_RS04260	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TCR_RS04265	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TCR_RS04270	COG0649	NAD binding
TCR_RS04275	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TCR_RS04285	COG1034	ATP synthesis coupled electron transport
TCR_RS04290	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TCR_RS04295	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TCR_RS04305	COG0713	ATP synthesis coupled electron transport
TCR_RS04320	COG1007	ATP synthesis coupled electron transport
TCR_RS04335	COG0582	viral genome integration into host DNA
TCR_RS04380	COG1850	ribulose-bisphosphate carboxylase activity
TCR_RS04410	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TCR_RS04415	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TCR_RS04420	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TCR_RS04430	COG2154	pterin-4-alpha-carbinolamine dehydratase
TCR_RS04450	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TCR_RS04455	COG0583	DNA-binding transcription factor activity
TCR_RS04460	COG2111	Na H antiporter
TCR_RS04460	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TCR_RS04465	COG3002	Belongs to the UPF0753 family
TCR_RS04470	COG0123	including yeast histone deacetylase and acetoin utilization protein
TCR_RS04490	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TCR_RS04495	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
TCR_RS04525	COG0497	DNA recombination
TCR_RS04530	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TCR_RS04535	COG1420	regulation of RNA biosynthetic process
TCR_RS04540	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TCR_RS04545	COG0443	Heat shock 70 kDa protein
TCR_RS04550	COG0484	heat shock protein binding
TCR_RS04555	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TCR_RS04570	COG2814	Major facilitator Superfamily
TCR_RS04580	COG0505	Belongs to the CarA family
TCR_RS04590	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TCR_RS04605	COG2833	Protein of unknown function (DUF455)
TCR_RS04615	COG1940	carbohydrate kinase activity
TCR_RS04625	COG1752	Esterase of the alpha-beta hydrolase superfamily
TCR_RS04630	COG0300	oxidoreductase activity
TCR_RS04640	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TCR_RS04645	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TCR_RS04650	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TCR_RS04655	COG0632	four-way junction helicase activity
TCR_RS04660	COG2255	four-way junction helicase activity
TCR_RS04670	COG0848	biopolymer transport protein
TCR_RS04680	COG0823	Involved in the tonB-independent uptake of proteins
TCR_RS04685	COG2885	chlorophyll binding
TCR_RS04695	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TCR_RS04725	COG3852	Histidine kinase
TCR_RS04730	COG2204	response regulator
TCR_RS04765	COG0688	phosphatidylethanolamine metabolic process
TCR_RS04770	COG0137	argininosuccinate synthase activity
TCR_RS04775	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TCR_RS04785	COG1301	dicarboxylic acid transport
TCR_RS04795	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TCR_RS04800	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TCR_RS04815	COG0215	cysteine-tRNA ligase activity
TCR_RS04825	COG3942	CHAP domain
TCR_RS04825	COG1388	LysM domain
TCR_RS04830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TCR_RS04835	COG2226	methyltransferase
TCR_RS04840	COG0328	RNA-DNA hybrid ribonuclease activity
TCR_RS04855	COG1047	Peptidyl-prolyl cis-trans
TCR_RS04865	COG3021	interspecies interaction between organisms
TCR_RS04870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TCR_RS04930	COG1187	pseudouridine synthase activity
TCR_RS04935	COG1028	Short-chain dehydrogenase reductase Sdr
TCR_RS04945	COG0330	HflC and HflK could
TCR_RS04950	COG0513	Belongs to the DEAD box helicase family
TCR_RS04960	COG1643	Atp-dependent helicase
TCR_RS04980	COG0004	ammonium transporteR
TCR_RS04985	COG1067	ATP-dependent peptidase activity
TCR_RS05000	COG1663	tetraacyldisaccharide 4'-kinase activity
TCR_RS05005	COG2835	tetraacyldisaccharide 4'-kinase activity
TCR_RS05010	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TCR_RS05020	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TCR_RS05055	COG2205	protein histidine kinase activity
TCR_RS05060	COG0745	RESPONSE REGULATOR receiver
TCR_RS05065	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TCR_RS05070	COG2239	Acts as a magnesium transporter
TCR_RS05080	COG1137	ATPase activity
TCR_RS05095	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
TCR_RS05110	COG1127	ABC transporter
TCR_RS05115	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TCR_RS05120	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TCR_RS05135	COG1131	(ABC) transporter
TCR_RS05140	COG0842	Transport permease protein
TCR_RS05150	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TCR_RS05155	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TCR_RS05160	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TCR_RS05165	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TCR_RS05170	COG0723	plastoquinol--plastocyanin reductase activity
TCR_RS05175	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TCR_RS05180	COG2857	Cytochrome c1
TCR_RS05185	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TCR_RS05195	COG4536	flavin adenine dinucleotide binding
TCR_RS05200	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TCR_RS05205	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TCR_RS05215	COG1051	belongs to the nudix hydrolase family
TCR_RS05225	COG0508	dehydrogenase complex catalyzes the overall conversion of
TCR_RS05230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TCR_RS05245	COG3530	Putative quorum-sensing-regulated virulence factor
TCR_RS05265	COG0655	NAD(P)H dehydrogenase (quinone) activity
TCR_RS05280	COG2249	NAD(P)H dehydrogenase (quinone) activity
TCR_RS05290	COG0513	Belongs to the DEAD box helicase family
TCR_RS05305	COG1192	Involved in chromosome partitioning
TCR_RS05320	COG3706	GGDEF domain
TCR_RS05325	COG0709	Synthesizes selenophosphate from selenide and ATP
TCR_RS05330	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
TCR_RS05345	COG0545	Peptidyl-prolyl cis-trans isomerase
TCR_RS05365	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TCR_RS05370	COG4660	Part of a membrane complex involved in electron transport
TCR_RS05375	COG4659	FMN binding
TCR_RS05380	COG4658	electron transport chain
TCR_RS05385	COG4656	Part of a membrane complex involved in electron transport
TCR_RS05390	COG2878	Part of a membrane complex involved in electron transport
TCR_RS05395	COG4657	Part of a membrane complex involved in electron transport
TCR_RS05400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TCR_RS05400	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TCR_RS05415	COG2205	protein histidine kinase activity
TCR_RS05415	COG4191	Histidine kinase
TCR_RS05415	COG0745	RESPONSE REGULATOR receiver
TCR_RS05420	COG3279	Response regulator of the LytR AlgR family
TCR_RS05430	COG0489	protein tyrosine kinase activity
TCR_RS05435	COG0717	Belongs to the dCTP deaminase family
TCR_RS05445	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TCR_RS05450	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TCR_RS05460	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TCR_RS05465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TCR_RS05485	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
TCR_RS05490	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
TCR_RS05525	COG2354	Protein conserved in bacteria
TCR_RS05545	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TCR_RS05555	COG3174	membrane
TCR_RS05570	COG3122	Protein conserved in bacteria
TCR_RS05595	COG0442	prolyl-tRNA aminoacylation
TCR_RS05600	COG1272	protein, Hemolysin III
TCR_RS05620	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TCR_RS05630	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TCR_RS05635	COG0802	atpase or kinase
TCR_RS05640	COG0860	N-Acetylmuramoyl-L-alanine amidase
TCR_RS05645	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TCR_RS05650	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TCR_RS05655	COG1923	regulation of RNA biosynthetic process
TCR_RS05660	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TCR_RS05675	COG0330	HflC and HflK could
TCR_RS05680	COG0330	HflC and HflK could
TCR_RS05690	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TCR_RS05695	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TCR_RS05705	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TCR_RS05715	COG2915	High frequency lysogenization protein hflD homolog
TCR_RS05720	COG0482	sulfurtransferase activity
TCR_RS05725	COG1187	pseudouridine synthase activity
TCR_RS05745	COG0217	transcriptional regulatory protein
TCR_RS05765	COG3706	GGDEF domain
TCR_RS05770	COG2824	Alkylphosphonate utilization operon protein PhnA
TCR_RS05775	COG0484	heat shock protein binding
TCR_RS05780	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TCR_RS05785	COG0542	response to heat
TCR_RS05790	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TCR_RS05795	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
TCR_RS05800	COG0587	DNA-directed DNA polymerase activity
TCR_RS05805	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TCR_RS05810	COG3162	membrane
TCR_RS05815	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TCR_RS05830	COG0779	Required for maturation of 30S ribosomal subunits
TCR_RS05835	COG2251	uridine kinase activity
TCR_RS05835	COG0195	Participates in both transcription termination and antitermination
TCR_RS05840	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TCR_RS05845	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TCR_RS05850	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TCR_RS05865	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TCR_RS05870	COG1185	polyribonucleotide nucleotidyltransferase activity
TCR_RS05885	COG2850	peptidyl-arginine hydroxylation
TCR_RS05890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TCR_RS05895	COG1131	(ABC) transporter
TCR_RS05900	COG1129	ABC transporter
TCR_RS05900	COG0842	Transport permease protein
TCR_RS05945	COG0616	signal peptide processing
TCR_RS05950	COG0322	excinuclease ABC activity
TCR_RS05995	COG3707	response regulator
TCR_RS06000	COG1116	anion transmembrane transporter activity
TCR_RS06000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TCR_RS06005	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TCR_RS06015	COG1116	anion transmembrane transporter activity
TCR_RS06020	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TCR_RS06025	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TCR_RS06030	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TCR_RS06030	COG2146	nitrite reductase [NAD(P)H] activity
TCR_RS06035	COG0243	molybdopterin cofactor binding
TCR_RS06040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TCR_RS06040	COG1648	precorrin-2 dehydrogenase activity
TCR_RS06045	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TCR_RS06050	COG0303	'Molybdopterin
TCR_RS06060	COG0850	regulation of cytokinetic process
TCR_RS06065	COG2894	cell division
TCR_RS06070	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TCR_RS06080	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TCR_RS06090	COG0446	pyridine nucleotide-disulphide oxidoreductase
TCR_RS06100	COG4591	ABC-type transport system involved in lipoprotein release permease component
TCR_RS06105	COG1136	(ABC) transporter
TCR_RS06110	COG0488	(ABC) transporter
TCR_RS06120	COG0544	peptidyl-prolyl cis-trans isomerase activity
TCR_RS06125	COG0740	serine-type endopeptidase activity
TCR_RS06130	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TCR_RS06135	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TCR_RS06175	COG0601	transmembrane transport
TCR_RS06180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TCR_RS06190	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TCR_RS06190	COG0574	Belongs to the PEP-utilizing enzyme family
TCR_RS06210	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TCR_RS06220	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TCR_RS06230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TCR_RS06235	COG0287	Prephenate dehydrogenase
TCR_RS06240	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TCR_RS06245	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TCR_RS06255	COG0776	regulation of translation
TCR_RS06265	COG0284	orotidine-5'-phosphate decarboxylase activity
TCR_RS06295	COG1393	Belongs to the ArsC family
TCR_RS06305	COG1570	exodeoxyribonuclease VII activity
TCR_RS06310	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TCR_RS06320	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TCR_RS06325	COG0363	glucosamine-6-phosphate deaminase activity
TCR_RS06330	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TCR_RS06335	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TCR_RS06360	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TCR_RS06400	COG2207	Transcriptional regulator
TCR_RS06410	COG0783	Belongs to the Dps family
TCR_RS06420	COG1187	pseudouridine synthase activity
TCR_RS06425	COG1994	Peptidase M50
TCR_RS06430	COG0009	L-threonylcarbamoyladenylate synthase
TCR_RS06435	COG0613	PHP domain protein
TCR_RS06440	COG2917	probably involved in intracellular septation
TCR_RS06445	COG2350	Protein conserved in bacteria
TCR_RS06450	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TCR_RS06470	COG3028	Belongs to the UPF0307 family
TCR_RS06475	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TCR_RS06485	COG1070	Carbohydrate kinase
TCR_RS06490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TCR_RS06525	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TCR_RS06540	COG0436	Aminotransferase
TCR_RS06550	COG4942	peptidase
TCR_RS06555	COG1238	metal cluster binding
TCR_RS06560	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TCR_RS06565	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TCR_RS06570	COG2840	Smr protein MutS2
TCR_RS06575	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TCR_RS06580	COG0148	phosphopyruvate hydratase activity
TCR_RS06585	COG2877	3-deoxy-8-phosphooctulonate synthase activity
TCR_RS06590	COG0504	CTP synthase activity
TCR_RS06595	COG0037	tRNA processing
TCR_RS06600	COG0825	malonyl-CoA metabolic process
TCR_RS06605	COG1944	ATP diphosphatase activity
TCR_RS06620	COG1214	PFAM Peptidase M22, glycoprotease
TCR_RS06625	COG1199	ATP-dependent helicase activity
TCR_RS06630	COG0835	chemotaxis
TCR_RS06630	COG0784	Response regulator, receiver
TCR_RS06635	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TCR_RS06640	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TCR_RS06645	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TCR_RS06650	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TCR_RS06655	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TCR_RS06670	COG0750	zinc metalloprotease
TCR_RS06675	COG0575	Belongs to the CDS family
TCR_RS06685	COG0233	cytoplasmic translational termination
TCR_RS06690	COG0528	UMP kinase activity
TCR_RS06695	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TCR_RS06700	COG0052	Belongs to the universal ribosomal protein uS2 family
TCR_RS06705	COG0024	Methionine aminopeptidase
TCR_RS06710	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
TCR_RS06720	COG2171	N-acyltransferase activity
TCR_RS06725	COG1393	Belongs to the ArsC family
TCR_RS06730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TCR_RS06745	COG0733	neurotransmitter:sodium symporter activity
TCR_RS06750	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TCR_RS06755	COG0668	transmembrane transport
TCR_RS06760	COG1472	Belongs to the glycosyl hydrolase 3 family
TCR_RS06770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TCR_RS06775	COG0601	transmembrane transport
TCR_RS06780	COG1376	ErfK ybiS ycfS ynhG family protein
TCR_RS06790	COG3647	Membrane
TCR_RS06805	COG2954	triphosphatase activity
TCR_RS06835	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TCR_RS06840	COG0826	peptidase U32
TCR_RS06850	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TCR_RS06855	COG1730	sister chromatid segregation
TCR_RS06910	COG1981	membrane
TCR_RS06915	COG1047	Peptidyl-prolyl cis-trans
TCR_RS06920	COG2983	Belongs to the UPF0260 family
TCR_RS06925	COG0564	pseudouridine synthase activity
TCR_RS06935	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TCR_RS06940	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TCR_RS06945	COG1862	Preprotein translocase
TCR_RS06950	COG0343	queuine tRNA-ribosyltransferase activity
TCR_RS06955	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TCR_RS06970	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TCR_RS06980	COG0347	Belongs to the P(II) protein family
TCR_RS06985	COG0004	ammonium transporteR
TCR_RS06995	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TCR_RS06995	COG0519	Catalyzes the synthesis of GMP from XMP
TCR_RS07000	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TCR_RS07005	COG0069	glutamate synthase activity
TCR_RS07010	COG2218	PFAM glutamate synthase alpha subunit domain protein
TCR_RS07015	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TCR_RS07030	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TCR_RS07030	COG0446	pyridine nucleotide-disulphide oxidoreductase
TCR_RS07045	COG0788	formyltetrahydrofolate deformylase activity
TCR_RS07075	COG3012	SEC-C Motif Domain Protein
TCR_RS07080	COG0534	Mate efflux family protein
TCR_RS07090	COG0494	nUDIX hydrolase
TCR_RS07095	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TCR_RS07105	COG0359	binds to the 23S rRNA
TCR_RS07115	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TCR_RS07120	COG0360	Binds together with S18 to 16S ribosomal RNA
TCR_RS07125	COG0716	FMN binding
TCR_RS07150	COG0564	pseudouridine synthase activity
TCR_RS07160	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TCR_RS07160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TCR_RS07165	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TCR_RS07170	COG0045	succinate-CoA ligase (ADP-forming) activity
TCR_RS07180	COG1047	Peptidyl-prolyl cis-trans
TCR_RS07185	COG3706	GGDEF domain
TCR_RS07210	COG2197	response regulator
TCR_RS07215	COG2205	protein histidine kinase activity
TCR_RS07215	COG0784	Response regulator, receiver
TCR_RS07225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TCR_RS07235	COG0450	alkyl hydroperoxide reductase
TCR_RS07240	COG0142	geranyltranstransferase activity
TCR_RS07245	COG0720	synthase
TCR_RS07255	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TCR_RS07265	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TCR_RS07270	COG0840	transmembrane signaling receptor activity
TCR_RS07275	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TCR_RS07280	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TCR_RS07285	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TCR_RS07300	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TCR_RS07300	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TCR_RS07305	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TCR_RS07310	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TCR_RS07315	COG0488	(ABC) transporter
TCR_RS07320	COG5001	Diguanylate cyclase
TCR_RS07320	COG3300	MHYT domain
TCR_RS07325	COG0735	belongs to the Fur family
TCR_RS07330	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TCR_RS07345	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TCR_RS07350	COG0582	viral genome integration into host DNA
TCR_RS07380	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TCR_RS07390	COG1522	sequence-specific DNA binding
TCR_RS07495	COG1360	Flagellar Motor Protein
TCR_RS07500	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TCR_RS07530	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TCR_RS07540	COG1677	Flagellar hook-basal body complex protein FliE
TCR_RS07565	COG1516	flagellar protein fliS
TCR_RS07570	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TCR_RS07585	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TCR_RS07590	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TCR_RS07600	COG1083	cytidylyl-transferase
TCR_RS07605	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TCR_RS07610	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TCR_RS07615	COG2089	acid synthase
TCR_RS07630	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TCR_RS07635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TCR_RS07640	COG0741	lytic transglycosylase activity
TCR_RS07660	COG1706	bacterial-type flagellum-dependent cell motility
TCR_RS07665	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TCR_RS07675	COG4787	bacterial-type flagellum-dependent cell motility
TCR_RS07680	COG1749	Flagellar hook protein flgE
TCR_RS07685	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TCR_RS07695	COG1815	bacterial-type flagellum-dependent cell motility
TCR_RS07705	COG0835	chemotaxis
TCR_RS07705	COG0784	Response regulator, receiver
TCR_RS07755	COG0308	aminopeptidase N
TCR_RS07760	COG2885	chlorophyll binding
TCR_RS07765	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TCR_RS07780	COG0557	exoribonuclease II activity
TCR_RS07785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TCR_RS07790	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
TCR_RS07795	COG0301	tRNA thio-modification
TCR_RS07795	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TCR_RS07805	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
TCR_RS07810	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TCR_RS07830	COG0004	ammonium transporteR
TCR_RS07840	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TCR_RS07845	COG0525	valine-tRNA ligase activity
TCR_RS07850	COG4991	sh3 domain protein
TCR_RS07885	COG1530	ribonuclease E activity
TCR_RS07890	COG0424	maF-like protein
TCR_RS07905	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TCR_RS07910	COG3307	-O-antigen
TCR_RS07925	COG3562	capsule polysaccharide
TCR_RS07935	COG0859	PFAM glycosyl transferase family 9
TCR_RS07940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TCR_RS07950	COG1132	(ABC) transporter
TCR_RS07955	COG1560	Kdo2-lipid A biosynthetic process
TCR_RS07960	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TCR_RS07965	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TCR_RS07975	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TCR_RS07980	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TCR_RS07985	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TCR_RS07990	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TCR_RS07995	COG0617	tRNA 3'-terminal CCA addition
TCR_RS08005	COG0180	Tryptophanyl-tRNA synthetase
TCR_RS08010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TCR_RS08015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TCR_RS08020	COG0659	secondary active sulfate transmembrane transporter activity
TCR_RS08025	COG3123	guanosine phosphorylase activity
TCR_RS08045	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TCR_RS08060	COG0667	Aldo Keto reductase
TCR_RS08065	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TCR_RS08070	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TCR_RS08080	COG3338	carbonate dehydratase activity
TCR_RS08090	COG0521	Mo-molybdopterin cofactor biosynthetic process
TCR_RS08095	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TCR_RS08105	COG0047	phosphoribosylformylglycinamidine synthase activity
TCR_RS08105	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TCR_RS08115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TCR_RS08120	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TCR_RS08125	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TCR_RS08130	COG0583	DNA-binding transcription factor activity
TCR_RS08135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TCR_RS08140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TCR_RS08145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TCR_RS08150	COG0006	proline dipeptidase activity
TCR_RS08155	COG3079	Belongs to the UPF0149 family
TCR_RS08165	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TCR_RS08195	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TCR_RS08200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TCR_RS08205	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TCR_RS08210	COG3101	peptidyl-lysine hydroxylation
TCR_RS08220	COG2132	Multicopper oxidase
TCR_RS08235	COG2132	Multicopper oxidase
TCR_RS08270	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TCR_RS08285	COG0668	transmembrane transport
TCR_RS08295	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TCR_RS08310	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TCR_RS08315	COG0527	aspartate kinase activity
TCR_RS08320	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TCR_RS08325	COG2137	regulation of response to DNA damage stimulus
TCR_RS08330	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TCR_RS08340	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TCR_RS08345	COG3118	belongs to the thioredoxin family
TCR_RS08355	COG0189	ligase activity
TCR_RS08360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TCR_RS08365	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TCR_RS08375	COG0438	transferase activity, transferring glycosyl groups
TCR_RS08385	COG0438	transferase activity, transferring glycosyl groups
TCR_RS08400	COG0488	(ABC) transporter
TCR_RS08405	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TCR_RS08410	COG1404	Belongs to the peptidase S8 family
TCR_RS08415	COG0326	Molecular chaperone. Has ATPase activity
TCR_RS08430	COG2198	Histidine kinase
TCR_RS08430	COG0643	Histidine kinase
TCR_RS08435	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TCR_RS08445	COG0519	Catalyzes the synthesis of GMP from XMP
TCR_RS08445	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TCR_RS08450	COG0516	GMP reductase activity
TCR_RS08450	COG0517	IMP dehydrogenase activity
TCR_RS08470	COG0560	Phosphoserine phosphatase
TCR_RS08475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TCR_RS08480	COG0811	peptide transport
TCR_RS08495	COG2166	iron-sulfur cluster assembly
TCR_RS08500	COG0501	Belongs to the peptidase M48B family
TCR_RS08505	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TCR_RS08510	COG0154	amidase activity
TCR_RS08515	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TCR_RS08520	COG1077	Cell shape determining protein MreB Mrl
TCR_RS08535	COG0768	penicillin binding
TCR_RS08540	COG0772	Belongs to the SEDS family
TCR_RS08545	COG1686	Belongs to the peptidase S11 family
TCR_RS08555	COG2921	Belongs to the UPF0250 family
TCR_RS08560	COG0321	lipoyl(octanoyl) transferase activity
TCR_RS08565	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TCR_RS08615	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TCR_RS08620	COG3022	response to hydroperoxide
TCR_RS08630	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TCR_RS08640	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
TCR_RS08645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TCR_RS08655	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TCR_RS08660	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TCR_RS08675	COG0776	regulation of translation
TCR_RS08680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TCR_RS08680	COG0072	phenylalanine-tRNA ligase activity
TCR_RS08685	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TCR_RS08690	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TCR_RS08695	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TCR_RS08700	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TCR_RS08705	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TCR_RS08725	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TCR_RS08730	COG1793	dna ligase
TCR_RS08755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TCR_RS08760	COG0662	Cupin 2, conserved barrel domain protein
TCR_RS08760	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
TCR_RS08765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TCR_RS08770	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
TCR_RS08790	COG1215	transferase activity, transferring glycosyl groups
TCR_RS08820	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TCR_RS08825	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TCR_RS08825	COG0543	2 iron, 2 sulfur cluster binding
TCR_RS08835	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TCR_RS08845	COG0792	nuclease activity
TCR_RS08855	COG1074	ATP-dependent DNA helicase activity
TCR_RS08895	COG4335	DNA alkylation repair
TCR_RS08910	COG0564	pseudouridine synthase activity
TCR_RS08915	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TCR_RS08915	COG0674	pyruvate-flavodoxin oxidoreductase activity
TCR_RS08920	COG1013	pyruvate-flavodoxin oxidoreductase activity
TCR_RS08940	COG0589	response to stress
TCR_RS08950	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TCR_RS08960	COG1304	FMN binding
TCR_RS08965	COG3425	synthase
TCR_RS09010	COG4964	Belongs to the GSP D family
TCR_RS09065	COG2969	positive regulation of protein catabolic process
TCR_RS09070	COG0625	glutathione transferase activity
TCR_RS09080	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TCR_RS09085	COG1509	lysine 2,3-aminomutase activity
TCR_RS09105	COG0795	lipopolysaccharide-transporting ATPase activity
TCR_RS09110	COG0795	lipopolysaccharide-transporting ATPase activity
TCR_RS09115	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TCR_RS09145	COG0556	nucleotide-excision repair
TCR_RS09150	COG0436	Aminotransferase
TCR_RS09155	COG0494	nUDIX hydrolase
TCR_RS09160	COG1011	Hydrolase
TCR_RS09165	COG0500	methyltransferase
TCR_RS09175	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TCR_RS09180	COG0488	(ABC) transporter
TCR_RS09190	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TCR_RS09230	COG1595	DNA-templated transcription, initiation
TCR_RS09235	COG1295	ribonuclease BN
TCR_RS09240	COG5001	Diguanylate cyclase
TCR_RS09240	COG3300	MHYT domain
TCR_RS09250	COG3220	belongs to the UPF0276 family
TCR_RS09265	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TCR_RS09280	COG0693	protein deglycase activity
TCR_RS09285	COG0793	Belongs to the peptidase S41A family
TCR_RS09290	COG0640	Transcriptional regulator
TCR_RS09340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TCR_RS09360	COG3665	Urea carboxylase-associated protein
TCR_RS09365	COG0439	Biotin carboxylase
TCR_RS09375	COG0438	transferase activity, transferring glycosyl groups
TCR_RS09380	COG3100	YcgL domain-containing protein
TCR_RS09380	COG0561	phosphatase activity
TCR_RS09385	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TCR_RS09385	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TCR_RS09405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TCR_RS09455	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TCR_RS09460	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TCR_RS09465	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TCR_RS09470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TCR_RS09490	COG1968	undecaprenyl-diphosphatase activity
TCR_RS09495	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TCR_RS09495	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TCR_RS09505	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TCR_RS09510	COG4943	cyclic-guanylate-specific phosphodiesterase activity
TCR_RS09515	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TCR_RS09520	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TCR_RS09525	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TCR_RS09535	COG0189	ligase activity
TCR_RS09545	COG1678	Uncharacterized ACR, COG1678
TCR_RS09550	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TCR_RS09555	COG0540	Belongs to the ATCase OTCase family
TCR_RS09560	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TCR_RS09590	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TCR_RS09605	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TCR_RS09610	COG2813	Specifically methylates the guanine in position
TCR_RS09610	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TCR_RS09640	COG0400	carboxylic ester hydrolase activity
TCR_RS09665	COG0509	glycine decarboxylation via glycine cleavage system
TCR_RS09735	COG1278	Cold shock
TCR_RS09745	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TCR_RS09770	COG0701	Predicted permease
TCR_RS09785	COG0579	oxidoreductase
TCR_RS09790	COG0523	cobalamin synthesis protein
TCR_RS09795	COG1469	GTP cyclohydrolase I activity
TCR_RS09805	COG1522	sequence-specific DNA binding
TCR_RS09810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TCR_RS09825	COG0628	permease
TCR_RS09830	COG1611	Belongs to the LOG family
TCR_RS09835	COG0513	Belongs to the DEAD box helicase family
TCR_RS09840	COG1309	transcriptional regulator
TCR_RS09855	COG1012	belongs to the aldehyde dehydrogenase family
TCR_RS09865	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TCR_RS09870	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TCR_RS09880	COG0248	Ppx GppA phosphatase
TCR_RS09885	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
TCR_RS09900	COG0588	phosphoglycerate mutase activity
TCR_RS09905	COG0840	transmembrane signaling receptor activity
TCR_RS09905	COG0840	transmembrane signaling receptor activity
TCR_RS09915	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TCR_RS09930	COG1666	GTP binding
TCR_RS09935	COG0436	Aminotransferase
TCR_RS09945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TCR_RS09950	COG0756	dUTP diphosphatase activity
TCR_RS09965	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TCR_RS09985	COG2205	protein histidine kinase activity
TCR_RS09985	COG0784	Response regulator, receiver
TCR_RS09995	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TCR_RS10005	COG2003	Belongs to the UPF0758 family
TCR_RS10010	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TCR_RS10015	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TCR_RS10030	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TCR_RS10040	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TCR_RS10050	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TCR_RS10075	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TCR_RS10085	COG0742	ribosomal rna small subunit methyltransferase
TCR_RS10115	COG1346	cytolysis
TCR_RS10125	COG0612	Peptidase, M16
TCR_RS10130	COG0612	Peptidase, M16
TCR_RS10135	COG0552	protein localization to endoplasmic reticulum
TCR_RS10155	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TCR_RS10165	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TCR_RS10200	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TCR_RS10205	COG0167	dihydroorotate dehydrogenase activity
TCR_RS10210	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TCR_RS10215	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TCR_RS10220	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
TCR_RS10230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TCR_RS10235	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TCR_RS10240	COG0069	glutamate synthase activity
TCR_RS10240	COG0067	glutamate synthase
TCR_RS10240	COG0070	glutamate synthase
TCR_RS10245	COG0493	'glutamate synthase
TCR_RS10255	COG2217	Heavy metal translocating P-type atpase
TCR_RS10285	COG3278	Belongs to the heme-copper respiratory oxidase family
TCR_RS10290	COG0131	Imidazoleglycerol-phosphate dehydratase
TCR_RS10295	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TCR_RS10300	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TCR_RS10305	COG0107	imidazoleglycerol-phosphate synthase activity
TCR_RS10310	COG0140	phosphoribosyl-ATP diphosphatase activity
TCR_RS10315	COG0537	adenosine 5'-monophosphoramidase activity
TCR_RS10320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TCR_RS10325	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TCR_RS10335	COG1331	Highly conserved protein containing a thioredoxin domain
TCR_RS10345	COG1040	competence protein
TCR_RS10350	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TCR_RS10355	COG0156	8-amino-7-oxononanoate synthase activity
TCR_RS10360	COG0596	Alpha beta hydrolase
TCR_RS10365	COG2226	methyltransferase
TCR_RS10380	COG0840	transmembrane signaling receptor activity
TCR_RS10380	COG0840	transmembrane signaling receptor activity
TCR_RS10395	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TCR_RS10405	COG0133	tryptophan synthase activity
TCR_RS10410	COG0742	ribosomal rna small subunit methyltransferase
TCR_RS10415	COG3040	lipid binding
TCR_RS10420	COG0259	pyridoxamine-phosphate oxidase activity
TCR_RS10435	COG1671	Belongs to the UPF0178 family
TCR_RS10440	COG0514	ATP-dependent DNA helicase (RecQ)
TCR_RS10445	COG0701	Predicted permease
TCR_RS10455	COG0840	transmembrane signaling receptor activity
TCR_RS10460	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TCR_RS10470	COG0583	DNA-binding transcription factor activity
TCR_RS10475	COG1741	Belongs to the pirin family
TCR_RS10495	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TCR_RS10515	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TCR_RS10560	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
TCR_RS10565	COG0390	transport system, permease component
TCR_RS10575	COG0071	Belongs to the small heat shock protein (HSP20) family
TCR_RS10595	COG1115	amino acid carrier protein
TCR_RS10605	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TCR_RS10610	COG1053	succinate dehydrogenase
TCR_RS10630	COG3228	Belongs to the MtfA family
TCR_RS10640	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TCR_RS10650	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
TCR_RS10655	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
TCR_RS10665	COG0309	Hydrogenase expression formation protein (HypE)
TCR_RS10670	COG0409	Hydrogenase expression formation protein
TCR_RS10675	COG0298	carbon dioxide binding
TCR_RS10680	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TCR_RS10695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TCR_RS10700	COG2897	thiosulfate sulfurtransferase activity
TCR_RS10705	COG5002	protein histidine kinase activity
TCR_RS10705	COG5001	Diguanylate cyclase
TCR_RS10715	COG1444	tRNA N-acetyltransferase activity
TCR_RS10720	COG0788	formyltetrahydrofolate deformylase activity
TCR_RS10725	COG0708	Exodeoxyribonuclease III
TCR_RS10730	COG0543	2 iron, 2 sulfur cluster binding
TCR_RS10730	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TCR_RS10735	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TCR_RS10740	COG1561	YicC-like family, N-terminal region
TCR_RS10755	COG3001	Fructosamine kinase
TCR_RS10760	COG0563	adenylate kinase activity
TCR_RS10765	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TCR_RS10770	COG2239	Acts as a magnesium transporter
TCR_RS10775	COG0189	ligase activity
TCR_RS10785	COG0189	ligase activity
TCR_RS10785	COG4067	protein conserved in archaea
TCR_RS10810	COG2198	Histidine kinase
TCR_RS10810	COG0784	Response regulator, receiver
TCR_RS10810	COG5002	protein histidine kinase activity
TCR_RS10820	COG0628	permease
TCR_RS10825	COG4572	Cation transport regulator
TCR_RS10860	COG2188	Transcriptional regulator
TCR_RS10870	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TCR_RS10885	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
TCR_RS10895	COG3627	carbon phosphorus lyase activity
TCR_RS10900	COG4107	phosphonate C-P lyase system protein PhnK
TCR_RS10905	COG4778	phosphonate C-P lyase system protein PhnL
TCR_RS10910	COG3454	Phosphonate metabolism
TCR_RS10915	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
TCR_RS10920	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TCR_RS10975	COG0640	Transcriptional regulator
TCR_RS10985	COG0672	)-iron permease
TCR_RS11000	COG3258	Cytochrome c
TCR_RS11025	COG2217	Heavy metal translocating P-type atpase
TCR_RS11040	COG2132	Multicopper oxidase
TCR_RS11055	COG2132	Multicopper oxidase
TCR_RS11080	COG0582	viral genome integration into host DNA
TCR_RS11110	COG0415	Belongs to the DNA photolyase family
TCR_RS11120	COG1366	Belongs to the anti-sigma-factor antagonist family
TCR_RS11130	COG1854	S-ribosylhomocysteine lyase activity
TCR_RS11135	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TCR_RS11145	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
TCR_RS11165	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TCR_RS11170	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TCR_RS11175	COG0194	GDP metabolic process
TCR_RS11180	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TCR_RS11185	COG1454	alcohol dehydrogenase
TCR_RS11190	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TCR_RS11200	COG1758	RNA polymerase activity
TCR_RS11205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TCR_RS11215	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TCR_RS11220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TCR_RS11220	COG1321	iron dependent repressor
TCR_RS11225	COG1121	(ABC) transporter
TCR_RS11230	COG0803	Belongs to the bacterial solute-binding protein 9 family
TCR_RS11240	COG0004	ammonium transporteR
TCR_RS11250	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TCR_RS11255	COG3161	chorismate lyase activity
TCR_RS11265	COG1595	DNA-templated transcription, initiation
TCR_RS11290	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TCR_RS11300	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TCR_RS11305	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TCR_RS11310	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TCR_RS11315	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TCR_RS11320	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TCR_RS11325	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TCR_RS11330	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TCR_RS11335	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TCR_RS11340	COG0356	it plays a direct role in the translocation of protons across the membrane
TCR_RS11360	COG1192	Involved in chromosome partitioning
TCR_RS11365	COG0357	Ribosomal RNA small subunit methyltransferase G
TCR_RS11370	COG0445	tRNA wobble uridine modification
TCR_RS11380	COG3437	response regulator, receiver
TCR_RS11385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TCR_RS11385	COG2205	protein histidine kinase activity
TCR_RS11400	COG3655	Transcriptional regulator
TCR_RS11405	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TCR_RS11410	COG0583	DNA-binding transcription factor activity
TCR_RS11420	COG2204	response regulator
TCR_RS11430	COG2205	protein histidine kinase activity
TCR_RS11440	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TCR_RS11440	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TCR_RS11450	COG1739	Uncharacterized protein family UPF0029
TCR_RS11460	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TCR_RS11465	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TCR_RS11475	COG0706	membrane insertase activity
TCR_RS11480	COG0594	ribonuclease P activity
TCR_RS11485	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TCR_RS11495	COG0730	response to heat
TCR_RS11525	COG0746	molybdenum cofactor guanylyltransferase activity