locus-tag	class	description
THICY_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THICY_RS00020	COG0446	pyridine nucleotide-disulphide oxidoreductase
THICY_RS00025	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THICY_RS00030	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
THICY_RS00035	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
THICY_RS00040	COG0314	molybdopterin synthase activity
THICY_RS00045	COG0303	'Molybdopterin
THICY_RS00050	COG0315	cyclic pyranopterin monophosphate synthase activity
THICY_RS00060	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
THICY_RS00065	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
THICY_RS00070	COG1854	S-ribosylhomocysteine lyase activity
THICY_RS00090	COG1322	Protein conserved in bacteria
THICY_RS00095	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THICY_RS00100	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
THICY_RS00110	COG0563	adenylate kinase activity
THICY_RS00125	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
THICY_RS00130	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
THICY_RS00135	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THICY_RS00145	COG0513	Belongs to the DEAD box helicase family
THICY_RS00175	COG1217	gtp-binding protein TYPA
THICY_RS00185	COG2391	methyltransferase activity
THICY_RS00190	COG0659	secondary active sulfate transmembrane transporter activity
THICY_RS00195	COG1410	methionine synthase
THICY_RS00195	COG0646	methionine synthase
THICY_RS00220	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THICY_RS00230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THICY_RS00235	COG1758	RNA polymerase activity
THICY_RS00240	COG0668	transmembrane transport
THICY_RS00245	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
THICY_RS00250	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THICY_RS00260	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
THICY_RS00270	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
THICY_RS00285	COG0543	2 iron, 2 sulfur cluster binding
THICY_RS00285	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
THICY_RS00295	COG0788	formyltetrahydrofolate deformylase activity
THICY_RS00300	COG1444	tRNA N-acetyltransferase activity
THICY_RS00305	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
THICY_RS00305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THICY_RS00330	COG0446	pyridine nucleotide-disulphide oxidoreductase
THICY_RS00340	COG1058	Belongs to the CinA family
THICY_RS00340	COG1546	Belongs to the CinA family
THICY_RS00345	COG2081	HI0933 family
THICY_RS00360	COG0678	peroxiredoxin activity
THICY_RS00360	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
THICY_RS00370	COG1519	Transferase
THICY_RS00375	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
THICY_RS00380	COG1454	alcohol dehydrogenase
THICY_RS00385	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THICY_RS00390	COG0194	GDP metabolic process
THICY_RS00395	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
THICY_RS00400	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
THICY_RS00405	COG0676	glucose-6-phosphate 1-epimerase activity
THICY_RS00420	COG3100	YcgL domain-containing protein
THICY_RS00425	COG0702	epimerase
THICY_RS00430	COG0617	tRNA 3'-terminal CCA addition
THICY_RS00450	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
THICY_RS00455	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
THICY_RS00460	COG0126	phosphoglycerate kinase activity
THICY_RS00465	COG0469	pyruvate kinase activity
THICY_RS00470	COG0191	fructose-bisphosphate aldolase activity
THICY_RS00495	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
THICY_RS00505	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
THICY_RS00510	COG0546	phosphoglycolate phosphatase activity
THICY_RS00515	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
THICY_RS00520	COG0512	Glutamine amidotransferase of anthranilate synthase
THICY_RS00525	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THICY_RS00530	COG0134	indole-3-glycerol-phosphate synthase activity
THICY_RS00535	COG1765	OsmC-like protein
THICY_RS00540	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
THICY_RS00545	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THICY_RS00550	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THICY_RS00550	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
THICY_RS00570	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THICY_RS00580	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THICY_RS00590	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
THICY_RS00595	COG0081	regulation of translation
THICY_RS00600	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
THICY_RS00610	COG0085	RNA polymerase activity
THICY_RS00615	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
THICY_RS00620	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
THICY_RS00625	COG0049	tRNA binding
THICY_RS00630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THICY_RS00635	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THICY_RS00640	COG0051	transcription antitermination factor activity, RNA binding
THICY_RS00645	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
THICY_RS00650	COG0088	Forms part of the polypeptide exit tunnel
THICY_RS00655	COG0089	rRNA binding
THICY_RS00660	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
THICY_RS00665	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
THICY_RS00670	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
THICY_RS00675	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
THICY_RS00680	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
THICY_RS00685	COG0255	Belongs to the universal ribosomal protein uL29 family
THICY_RS00690	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
THICY_RS00695	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
THICY_RS00700	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
THICY_RS00705	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
THICY_RS00710	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
THICY_RS00715	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
THICY_RS00720	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
THICY_RS00725	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
THICY_RS00730	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
THICY_RS00735	COG1841	ribosomal large subunit assembly
THICY_RS00740	COG0200	Binds to the 23S rRNA
THICY_RS00745	COG0201	protein transport
THICY_RS00750	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
THICY_RS00755	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
THICY_RS00760	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
THICY_RS00765	COG0202	RNA polymerase activity
THICY_RS00770	COG0203	ribosomal protein L17
THICY_RS00775	COG0084	hydrolase, TatD family'
THICY_RS00780	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
THICY_RS00790	COG0019	diaminopimelate decarboxylase activity
THICY_RS00800	COG0400	carboxylic ester hydrolase activity
THICY_RS00810	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THICY_RS00835	COG0415	Belongs to the DNA photolyase family
THICY_RS00840	COG3046	protein related to deoxyribodipyrimidine photolyase
THICY_RS00845	COG2814	Major facilitator Superfamily
THICY_RS00855	COG0142	geranyltranstransferase activity
THICY_RS00860	COG0261	This protein binds to 23S rRNA in the presence of protein L20
THICY_RS00865	COG0211	Belongs to the bacterial ribosomal protein bL27 family
THICY_RS00870	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THICY_RS00875	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
THICY_RS00880	COG0477	Major facilitator Superfamily
THICY_RS00890	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
THICY_RS00900	COG0459	protein refolding
THICY_RS00905	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
THICY_RS00910	COG0316	Belongs to the HesB IscA family
THICY_RS00920	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
THICY_RS00925	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
THICY_RS00930	COG1366	Belongs to the anti-sigma-factor antagonist family
THICY_RS00940	COG0415	Belongs to the DNA photolyase family
THICY_RS00955	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
THICY_RS00970	COG0300	oxidoreductase activity
THICY_RS00985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THICY_RS00990	COG1121	(ABC) transporter
THICY_RS01005	COG0719	Fe-S assembly protein
THICY_RS01010	COG0396	ATPase activity
THICY_RS01015	COG0719	Fe-S assembly protein
THICY_RS01025	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THICY_RS01030	COG1181	Belongs to the D-alanine--D-alanine ligase family
THICY_RS01045	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
THICY_RS01055	COG0653	protein targeting
THICY_RS01060	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
THICY_RS01065	COG0352	thiamine-phosphate diphosphorylase activity
THICY_RS01070	COG0237	dephospho-CoA kinase activity
THICY_RS01080	COG0367	asparagine synthase
THICY_RS01085	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
THICY_RS01095	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
THICY_RS01095	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THICY_RS01100	COG0129	dihydroxy-acid dehydratase activity
THICY_RS01110	COG3258	Cytochrome c
THICY_RS01140	COG1210	Utp--glucose-1-phosphate uridylyltransferase
THICY_RS01145	COG0166	Belongs to the GPI family
THICY_RS01155	COG1183	phosphatidylcholine synthase activity
THICY_RS01160	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THICY_RS01170	COG0456	acetyltransferase
THICY_RS01190	COG1959	2 iron, 2 sulfur cluster binding
THICY_RS01195	COG0316	Belongs to the HesB IscA family
THICY_RS01200	COG0105	UTP biosynthetic process
THICY_RS01205	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THICY_RS01215	COG0124	histidyl-tRNA synthetase
THICY_RS01225	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THICY_RS01230	COG1160	GTP binding
THICY_RS01235	COG0277	FAD linked oxidase domain protein
THICY_RS01250	COG1162	GTPase activity
THICY_RS01255	COG2154	pterin-4-alpha-carbinolamine dehydratase
THICY_RS01260	COG0501	Belongs to the peptidase M48B family
THICY_RS01265	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
THICY_RS01270	COG0028	Belongs to the TPP enzyme family
THICY_RS01280	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
THICY_RS01285	COG0493	'glutamate synthase
THICY_RS01290	COG0070	glutamate synthase
THICY_RS01290	COG0069	glutamate synthase activity
THICY_RS01290	COG0067	glutamate synthase
THICY_RS01295	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
THICY_RS01300	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
THICY_RS01305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THICY_RS01315	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
THICY_RS01320	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
THICY_RS01325	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
THICY_RS01330	COG0167	dihydroorotate dehydrogenase activity
THICY_RS01335	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
THICY_RS01370	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
THICY_RS01380	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THICY_RS01395	COG0552	protein localization to endoplasmic reticulum
THICY_RS01400	COG0612	Peptidase, M16
THICY_RS01405	COG0612	Peptidase, M16
THICY_RS01410	COG0742	ribosomal rna small subunit methyltransferase
THICY_RS01415	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
THICY_RS01425	COG1666	GTP binding
THICY_RS01430	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THICY_RS01440	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
THICY_RS01450	COG0248	Ppx GppA phosphatase
THICY_RS01460	COG0628	permease
THICY_RS01475	COG0756	dUTP diphosphatase activity
THICY_RS01485	COG0811	peptide transport
THICY_RS01510	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
THICY_RS01515	COG1090	epimerase
THICY_RS01530	COG0509	glycine decarboxylation via glycine cleavage system
THICY_RS01540	COG1012	belongs to the aldehyde dehydrogenase family
THICY_RS01545	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
THICY_RS01595	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
THICY_RS01625	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
THICY_RS01630	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
THICY_RS01650	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
THICY_RS01655	COG0540	Belongs to the ATCase OTCase family
THICY_RS01660	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
THICY_RS01665	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
THICY_RS01670	COG1678	Uncharacterized ACR, COG1678
THICY_RS01680	COG0189	ligase activity
THICY_RS01685	COG2308	Evidence 4 Homologs of previously reported genes of
THICY_RS01700	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
THICY_RS01700	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THICY_RS01710	COG0227	Belongs to the bacterial ribosomal protein bL28 family
THICY_RS01715	COG2003	Belongs to the UPF0758 family
THICY_RS01720	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
THICY_RS01720	COG2813	Specifically methylates the guanine in position
THICY_RS01725	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
THICY_RS01730	COG0762	integral membrane protein
THICY_RS01740	COG1469	GTP cyclohydrolase I activity
THICY_RS01745	COG0523	cobalamin synthesis protein
THICY_RS01750	COG0579	oxidoreductase
THICY_RS01760	COG0667	Aldo Keto reductase
THICY_RS01770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THICY_RS01815	COG0653	protein targeting
THICY_RS01825	COG0308	aminopeptidase N
THICY_RS01840	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
THICY_RS01850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THICY_RS01860	COG4771	TonB-dependent receptor
THICY_RS01865	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
THICY_RS01875	COG2226	methyltransferase
THICY_RS01885	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
THICY_RS01895	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
THICY_RS01900	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
THICY_RS01915	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
THICY_RS01920	COG0500	methyltransferase
THICY_RS01930	COG0542	response to heat
THICY_RS01935	COG2982	Protein involved in outer membrane biogenesis
THICY_RS01985	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
THICY_RS01990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THICY_RS01995	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
THICY_RS02005	COG0138	bifunctional purine biosynthesis protein purh
THICY_RS02010	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
THICY_RS02020	COG2264	protein methyltransferase activity
THICY_RS02025	COG0439	Biotin carboxylase
THICY_RS02035	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
THICY_RS02040	COG4232	protein-disulfide reductase activity
THICY_RS02045	COG3030	protein affecting phage T7 exclusion by the F plasmid
THICY_RS02055	COG0500	methyltransferase
THICY_RS02065	COG1187	pseudouridine synthase activity
THICY_RS02125	COG0725	ABC transporter, periplasmic molybdate-binding protein
THICY_RS02135	COG1396	sequence-specific DNA binding
THICY_RS02140	COG3550	peptidyl-serine autophosphorylation
THICY_RS02145	COG0798	PFAM Bile acid sodium symporter
THICY_RS02155	COG3852	Histidine kinase
THICY_RS02175	COG0488	(ABC) transporter
THICY_RS02180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THICY_RS02185	COG1011	Hydrolase
THICY_RS02190	COG0494	nUDIX hydrolase
THICY_RS02195	COG1218	3'(2'),5'-bisphosphate nucleotidase
THICY_RS02200	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
THICY_RS02205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THICY_RS02210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THICY_RS02215	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
THICY_RS02225	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THICY_RS02230	COG0521	Mo-molybdopterin cofactor biosynthetic process
THICY_RS02235	COG2890	protein-(glutamine-N5) methyltransferase activity
THICY_RS02240	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
THICY_RS02245	COG2814	Major facilitator Superfamily
THICY_RS02255	COG3123	guanosine phosphorylase activity
THICY_RS02265	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
THICY_RS02270	COG0848	biopolymer transport protein
THICY_RS02275	COG0811	peptide transport
THICY_RS02285	COG0560	Phosphoserine phosphatase
THICY_RS02310	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THICY_RS02310	COG0519	Catalyzes the synthesis of GMP from XMP
THICY_RS02325	COG0326	Molecular chaperone. Has ATPase activity
THICY_RS02335	COG0564	pseudouridine synthase activity
THICY_RS02340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THICY_RS02350	COG1137	ATPase activity
THICY_RS02365	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
THICY_RS02380	COG1127	ABC transporter
THICY_RS02385	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
THICY_RS02390	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
THICY_RS02405	COG1131	(ABC) transporter
THICY_RS02410	COG0842	Transport permease protein
THICY_RS02420	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THICY_RS02425	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
THICY_RS02430	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
THICY_RS02435	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THICY_RS02440	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
THICY_RS02445	COG0723	plastoquinol--plastocyanin reductase activity
THICY_RS02450	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
THICY_RS02455	COG2857	Cytochrome c1
THICY_RS02465	COG0483	inositol monophosphate 1-phosphatase activity
THICY_RS02470	COG4536	flavin adenine dinucleotide binding
THICY_RS02480	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THICY_RS02485	COG0228	four-way junction DNA binding
THICY_RS02490	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
THICY_RS02495	COG0336	Belongs to the RNA methyltransferase TrmD family
THICY_RS02500	COG0335	large ribosomal subunit rRNA binding
THICY_RS02515	COG0189	ligase activity
THICY_RS02535	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THICY_RS02540	COG1546	Belongs to the CinA family
THICY_RS02545	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
THICY_RS02550	COG2137	regulation of response to DNA damage stimulus
THICY_RS02555	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
THICY_RS02580	COG0802	atpase or kinase
THICY_RS02590	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
THICY_RS02595	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
THICY_RS02600	COG1923	regulation of RNA biosynthetic process
THICY_RS02605	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
THICY_RS02610	COG0330	HflC and HflK could
THICY_RS02615	COG0330	HflC and HflK could
THICY_RS02620	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
THICY_RS02625	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
THICY_RS02630	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
THICY_RS02645	COG0668	transmembrane transport
THICY_RS02655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THICY_RS02660	COG0232	Belongs to the dGTPase family. Type 2 subfamily
THICY_RS02665	COG1671	Belongs to the UPF0178 family
THICY_RS02670	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
THICY_RS02675	COG1074	ATP-dependent DNA helicase activity
THICY_RS02680	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
THICY_RS02685	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
THICY_RS02760	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
THICY_RS02780	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
THICY_RS02800	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THICY_RS02860	COG1047	Peptidyl-prolyl cis-trans
THICY_RS02870	COG1643	Atp-dependent helicase
THICY_RS02880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THICY_RS02905	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
THICY_RS02920	COG4628	conserved protein (DUF2132)
THICY_RS02935	COG4206	TonB-dependent receptor
THICY_RS02950	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THICY_RS02960	COG4659	FMN binding
THICY_RS02965	COG4658	electron transport chain
THICY_RS02975	COG2878	Part of a membrane complex involved in electron transport
THICY_RS02980	COG4657	Part of a membrane complex involved in electron transport
THICY_RS02985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THICY_RS02985	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THICY_RS02990	COG0489	protein tyrosine kinase activity
THICY_RS02995	COG0717	Belongs to the dCTP deaminase family
THICY_RS03005	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
THICY_RS03010	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
THICY_RS03025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THICY_RS03050	COG0442	prolyl-tRNA aminoacylation
THICY_RS03055	COG0424	maF-like protein
THICY_RS03095	COG2890	protein-(glutamine-N5) methyltransferase activity
THICY_RS03100	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
THICY_RS03105	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
THICY_RS03115	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
THICY_RS03120	COG1917	Cupin 2, conserved barrel domain protein
THICY_RS03125	COG2205	protein histidine kinase activity
THICY_RS03125	COG0784	Response regulator, receiver
THICY_RS03135	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
THICY_RS03145	COG0602	queuosine metabolic process
THICY_RS03150	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THICY_RS03160	COG0473	3-isopropylmalate dehydrogenase activity
THICY_RS03165	COG0739	heme binding
THICY_RS03175	COG0101	tRNA pseudouridine synthase activity
THICY_RS03180	COG0135	phosphoribosylanthranilate isomerase activity
THICY_RS03185	COG0133	tryptophan synthase activity
THICY_RS03190	COG0159	tryptophan synthase activity
THICY_RS03195	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
THICY_RS03200	COG0285	dihydrofolate synthase activity
THICY_RS03220	COG1534	Rna-binding protein
THICY_RS03225	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
THICY_RS03235	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
THICY_RS03240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THICY_RS03245	COG0149	triose-phosphate isomerase activity
THICY_RS03260	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THICY_RS03265	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THICY_RS03270	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THICY_RS03275	COG0649	NAD binding
THICY_RS03290	COG1034	ATP synthesis coupled electron transport
THICY_RS03295	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
THICY_RS03300	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THICY_RS03310	COG0713	ATP synthesis coupled electron transport
THICY_RS03325	COG1007	ATP synthesis coupled electron transport
THICY_RS03340	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THICY_RS03345	COG1047	Peptidyl-prolyl cis-trans
THICY_RS03350	COG1981	membrane
THICY_RS03355	COG0488	(ABC) transporter
THICY_RS03380	COG0544	peptidyl-prolyl cis-trans isomerase activity
THICY_RS03385	COG0740	serine-type endopeptidase activity
THICY_RS03390	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
THICY_RS03395	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THICY_RS03420	COG2850	peptidyl-arginine hydroxylation
THICY_RS03430	COG1049	propionate catabolic process, 2-methylcitrate cycle
THICY_RS03450	COG1321	iron dependent repressor
THICY_RS03450	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THICY_RS03455	COG1121	(ABC) transporter
THICY_RS03460	COG0803	Belongs to the bacterial solute-binding protein 9 family
THICY_RS03475	COG2204	response regulator
THICY_RS03485	COG0688	phosphatidylethanolamine metabolic process
THICY_RS03490	COG0137	argininosuccinate synthase activity
THICY_RS03495	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
THICY_RS03505	COG1301	dicarboxylic acid transport
THICY_RS03510	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THICY_RS03515	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
THICY_RS03525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THICY_RS03530	COG0215	cysteine-tRNA ligase activity
THICY_RS03535	COG0741	lytic transglycosylase activity
THICY_RS03540	COG0741	lytic transglycosylase activity
THICY_RS03540	COG1388	LysM domain
THICY_RS03545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THICY_RS03555	COG0328	RNA-DNA hybrid ribonuclease activity
THICY_RS03565	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THICY_RS03575	COG1496	oxidoreductase activity
THICY_RS03585	COG3023	N-Acetylmuramoyl-L-alanine amidase
THICY_RS03590	COG0716	FMN binding
THICY_RS03600	COG1051	belongs to the nudix hydrolase family
THICY_RS03605	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
THICY_RS03610	COG0508	dehydrogenase complex catalyzes the overall conversion of
THICY_RS03615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THICY_RS03620	COG0564	pseudouridine synthase activity
THICY_RS03625	COG2983	Belongs to the UPF0260 family
THICY_RS03635	COG1944	ATP diphosphatase activity
THICY_RS03645	COG0825	malonyl-CoA metabolic process
THICY_RS03650	COG0037	tRNA processing
THICY_RS03655	COG0504	CTP synthase activity
THICY_RS03660	COG2877	3-deoxy-8-phosphooctulonate synthase activity
THICY_RS03665	COG0148	phosphopyruvate hydratase activity
THICY_RS03670	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
THICY_RS03685	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THICY_RS03690	COG1238	metal cluster binding
THICY_RS03700	COG0436	Aminotransferase
THICY_RS03715	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
THICY_RS03720	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
THICY_RS03720	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
THICY_RS03730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THICY_RS03735	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
THICY_RS03745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THICY_RS03755	COG1070	Carbohydrate kinase
THICY_RS03760	COG1196	nuclear chromosome segregation
THICY_RS03770	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THICY_RS03775	COG3028	Belongs to the UPF0307 family
THICY_RS03785	COG0252	asparaginase activity
THICY_RS03790	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
THICY_RS03795	COG2350	Protein conserved in bacteria
THICY_RS03800	COG2917	probably involved in intracellular septation
THICY_RS03805	COG0613	PHP domain protein
THICY_RS03810	COG0009	L-threonylcarbamoyladenylate synthase
THICY_RS03815	COG1994	Peptidase M50
THICY_RS03820	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
THICY_RS03825	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
THICY_RS03830	COG1187	pseudouridine synthase activity
THICY_RS03855	COG2954	triphosphatase activity
THICY_RS03890	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
THICY_RS03895	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
THICY_RS03900	COG0363	glucosamine-6-phosphate deaminase activity
THICY_RS03910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THICY_RS03915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THICY_RS03925	COG0322	excinuclease ABC activity
THICY_RS03960	COG0582	viral genome integration into host DNA
THICY_RS04015	COG3012	SEC-C Motif Domain Protein
THICY_RS04020	COG3707	response regulator
THICY_RS04025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THICY_RS04030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THICY_RS04035	COG1116	anion transmembrane transporter activity
THICY_RS04040	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THICY_RS04045	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THICY_RS04055	COG0243	molybdopterin cofactor binding
THICY_RS04060	COG1648	precorrin-2 dehydrogenase activity
THICY_RS04060	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
THICY_RS04070	COG0303	'Molybdopterin
THICY_RS04080	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
THICY_RS04100	COG1570	exodeoxyribonuclease VII activity
THICY_RS04100	COG1570	exodeoxyribonuclease VII activity
THICY_RS04125	COG0745	RESPONSE REGULATOR receiver
THICY_RS04150	COG0494	nUDIX hydrolase
THICY_RS04155	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
THICY_RS04165	COG0359	binds to the 23S rRNA
THICY_RS04175	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
THICY_RS04180	COG0360	Binds together with S18 to 16S ribosomal RNA
THICY_RS04185	COG0284	orotidine-5'-phosphate decarboxylase activity
THICY_RS04195	COG0776	regulation of translation
THICY_RS04210	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
THICY_RS04215	COG0287	Prephenate dehydrogenase
THICY_RS04220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THICY_RS04230	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
THICY_RS04240	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THICY_RS04250	COG1028	Short-chain dehydrogenase reductase Sdr
THICY_RS04265	COG2183	response to ionizing radiation
THICY_RS04270	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
THICY_RS04275	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
THICY_RS04295	COG0659	secondary active sulfate transmembrane transporter activity
THICY_RS04305	COG0047	phosphoribosylformylglycinamidine synthase activity
THICY_RS04305	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THICY_RS04315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THICY_RS04320	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THICY_RS04325	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
THICY_RS04340	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
THICY_RS04400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THICY_RS04405	COG0601	transmembrane transport
THICY_RS04425	COG1185	polyribonucleotide nucleotidyltransferase activity
THICY_RS04430	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
THICY_RS04445	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
THICY_RS04450	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
THICY_RS04455	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
THICY_RS04460	COG0195	Participates in both transcription termination and antitermination
THICY_RS04460	COG2251	uridine kinase activity
THICY_RS04465	COG0779	Required for maturation of 30S ribosomal subunits
THICY_RS04480	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
THICY_RS04490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THICY_RS04495	COG0587	DNA-directed DNA polymerase activity
THICY_RS04500	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
THICY_RS04515	COG1053	succinate dehydrogenase
THICY_RS04520	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
THICY_RS04530	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
THICY_RS04535	COG0736	holo-[acyl-carrier-protein] synthase activity
THICY_RS04540	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
THICY_RS04545	COG1381	Involved in DNA repair and RecF pathway recombination
THICY_RS04550	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
THICY_RS04565	COG0481	GTPase activity
THICY_RS04570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THICY_RS04600	COG2161	toxin-antitoxin pair type II binding
THICY_RS04625	COG2827	Endonuclease containing a URI domain
THICY_RS04630	COG5611	PilT protein domain protein
THICY_RS04650	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
THICY_RS04655	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
THICY_RS04660	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
THICY_RS04665	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
THICY_RS04730	COG0584	glycerophosphoryl diester phosphodiesterase
THICY_RS04735	COG0463	Glycosyl transferase, family 2
THICY_RS04735	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
THICY_RS04745	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
THICY_RS04800	COG0859	PFAM glycosyl transferase family 9
THICY_RS04820	COG0859	PFAM glycosyl transferase family 9
THICY_RS04835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THICY_RS04850	COG1132	(ABC) transporter
THICY_RS04875	COG0589	response to stress
THICY_RS04880	COG1214	PFAM Peptidase M22, glycoprotease
THICY_RS04885	COG1199	ATP-dependent helicase activity
THICY_RS04890	COG0257	Belongs to the bacterial ribosomal protein bL36 family
THICY_RS04895	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
THICY_RS04900	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THICY_RS04905	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THICY_RS04910	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THICY_RS04915	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THICY_RS04920	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
THICY_RS04925	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THICY_RS04935	COG0575	Belongs to the CDS family
THICY_RS04940	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
THICY_RS04945	COG0233	cytoplasmic translational termination
THICY_RS04950	COG0528	UMP kinase activity
THICY_RS04955	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
THICY_RS04960	COG0052	Belongs to the universal ribosomal protein uS2 family
THICY_RS04965	COG0024	Methionine aminopeptidase
THICY_RS04970	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
THICY_RS05000	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
THICY_RS05010	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
THICY_RS05015	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THICY_RS05020	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
THICY_RS05025	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
THICY_RS05030	COG0531	amino acid
THICY_RS05030	COG1674	ftsk spoiiie
THICY_RS05035	COG0492	ferredoxin-NADP+ reductase activity
THICY_RS05040	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
THICY_RS05045	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THICY_RS05050	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THICY_RS05055	COG1862	Preprotein translocase
THICY_RS05060	COG0343	queuine tRNA-ribosyltransferase activity
THICY_RS05065	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
THICY_RS05125	COG1459	type II secretion system
THICY_RS05130	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THICY_RS05140	COG3031	protein transport across the cell outer membrane
THICY_RS05145	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
THICY_RS05155	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
THICY_RS05160	COG0354	folic acid binding
THICY_RS05180	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
THICY_RS05195	COG0823	Involved in the tonB-independent uptake of proteins
THICY_RS05205	COG0848	biopolymer transport protein
THICY_RS05215	COG2255	four-way junction helicase activity
THICY_RS05220	COG0632	four-way junction helicase activity
THICY_RS05225	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
THICY_RS05235	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
THICY_RS05240	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
THICY_RS05250	COG0300	oxidoreductase activity
THICY_RS05255	COG0142	geranyltranstransferase activity
THICY_RS05260	COG0720	synthase
THICY_RS05275	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
THICY_RS05280	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
THICY_RS05285	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THICY_RS05290	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
THICY_RS05305	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THICY_RS05305	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THICY_RS05310	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THICY_RS05315	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
THICY_RS05320	COG0488	(ABC) transporter
THICY_RS05325	COG2203	Gaf domain
THICY_RS05325	COG2199	diguanylate cyclase activity
THICY_RS05335	COG2197	response regulator
THICY_RS05345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THICY_RS05350	COG1940	carbohydrate kinase activity
THICY_RS05355	COG2833	Protein of unknown function (DUF455)
THICY_RS05365	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
THICY_RS05375	COG0505	Belongs to the CarA family
THICY_RS05380	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
THICY_RS05385	COG0484	heat shock protein binding
THICY_RS05390	COG0443	Heat shock 70 kDa protein
THICY_RS05395	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THICY_RS05400	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
THICY_RS05405	COG0497	DNA recombination
THICY_RS05410	COG0735	belongs to the Fur family
THICY_RS05415	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THICY_RS05420	COG2914	Belongs to the UPF0125 (RnfH) family
THICY_RS05425	COG2867	negative regulation of translational initiation
THICY_RS05430	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
THICY_RS05440	COG4181	ATPase activity
THICY_RS05450	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
THICY_RS05460	COG1999	signal sequence binding
THICY_RS05485	COG0488	(ABC) transporter
THICY_RS05490	COG1136	(ABC) transporter
THICY_RS05505	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
THICY_RS05515	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
THICY_RS05525	COG0850	regulation of cytokinetic process
THICY_RS05530	COG3150	esterase
THICY_RS05540	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
THICY_RS05545	COG2835	tetraacyldisaccharide 4'-kinase activity
THICY_RS05550	COG1663	tetraacyldisaccharide 4'-kinase activity
THICY_RS05560	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
THICY_RS05580	COG2333	competence protein COMEC
THICY_RS05580	COG0658	competence protein
THICY_RS05590	COG1067	ATP-dependent peptidase activity
THICY_RS05595	COG2515	1-aminocyclopropane-1-carboxylate deaminase
THICY_RS05615	COG0542	response to heat
THICY_RS05620	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
THICY_RS05630	COG0482	sulfurtransferase activity
THICY_RS05635	COG2915	High frequency lysogenization protein hflD homolog
THICY_RS05640	COG0625	glutathione transferase activity
THICY_RS05645	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
THICY_RS05650	COG0826	peptidase U32
THICY_RS05660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THICY_RS05670	COG0346	lactoylglutathione lyase activity
THICY_RS05680	COG1393	Belongs to the ArsC family
THICY_RS05685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
THICY_RS05700	COG0733	neurotransmitter:sodium symporter activity
THICY_RS05710	COG1472	Belongs to the glycosyl hydrolase 3 family
THICY_RS05715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THICY_RS05720	COG0601	transmembrane transport
THICY_RS05735	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
THICY_RS05740	COG0045	succinate-CoA ligase (ADP-forming) activity
THICY_RS05750	COG1047	Peptidyl-prolyl cis-trans
THICY_RS05775	COG1132	(ABC) transporter
THICY_RS05780	COG0084	hydrolase, TatD family'
THICY_RS05790	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
THICY_RS05795	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
THICY_RS05800	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
THICY_RS05805	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
THICY_RS05810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THICY_RS05815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THICY_RS05825	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
THICY_RS05830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THICY_RS05835	COG0416	fatty acid biosynthetic process
THICY_RS05840	COG0333	Belongs to the bacterial ribosomal protein bL32 family
THICY_RS05845	COG1399	metal-binding, possibly nucleic acid-binding protein
THICY_RS05850	COG0424	maF-like protein
THICY_RS05855	COG0546	phosphoglycolate phosphatase activity
THICY_RS05865	COG1530	ribonuclease E activity
THICY_RS05880	COG0583	DNA-binding transcription factor activity
THICY_RS05885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
THICY_RS05890	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
THICY_RS05895	COG0006	proline dipeptidase activity
THICY_RS05920	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
THICY_RS05945	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THICY_RS05960	COG0116	Belongs to the methyltransferase superfamily
THICY_RS05960	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
THICY_RS05965	COG2951	lytic endotransglycosylase activity
THICY_RS05970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THICY_RS05980	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
THICY_RS05985	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
THICY_RS05990	COG0196	riboflavin kinase activity
THICY_RS06000	COG0028	Belongs to the TPP enzyme family
THICY_RS06015	COG0259	pyridoxamine-phosphate oxidase activity
THICY_RS06020	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
THICY_RS06030	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
THICY_RS06035	COG0751	glycine-tRNA ligase activity
THICY_RS06040	COG0752	glycyl-tRNA synthetase alpha subunit
THICY_RS06050	COG0739	heme binding
THICY_RS06055	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
THICY_RS06070	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THICY_RS06075	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THICY_RS06080	COG1595	DNA-templated transcription, initiation
THICY_RS06110	COG0330	HflC and HflK could
THICY_RS06125	COG0651	ATP synthesis coupled electron transport
THICY_RS06155	COG0714	Associated with various cellular activities
THICY_RS06170	COG0513	Belongs to the DEAD box helicase family
THICY_RS06200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THICY_RS06200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THICY_RS06210	COG3001	Fructosamine kinase
THICY_RS06215	COG2133	pyrroloquinoline quinone binding
THICY_RS06220	COG0651	ATP synthesis coupled electron transport
THICY_RS06225	COG0651	ATP synthesis coupled electron transport
THICY_RS06230	COG0713	ATP synthesis coupled electron transport
THICY_RS06255	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
THICY_RS06260	COG0306	phosphate transporter
THICY_RS06265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THICY_RS06270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THICY_RS06275	COG0557	exoribonuclease II activity
THICY_RS06285	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
THICY_RS06290	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
THICY_RS06295	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
THICY_RS06300	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
THICY_RS06305	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
THICY_RS06310	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
THICY_RS06315	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
THICY_RS06320	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
THICY_RS06325	COG0617	tRNA 3'-terminal CCA addition
THICY_RS06335	COG0501	Belongs to the peptidase M48B family
THICY_RS06340	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THICY_RS06345	COG0154	amidase activity
THICY_RS06350	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THICY_RS06355	COG1077	Cell shape determining protein MreB Mrl
THICY_RS06370	COG0768	penicillin binding
THICY_RS06375	COG0772	Belongs to the SEDS family
THICY_RS06380	COG1686	Belongs to the peptidase S11 family
THICY_RS06390	COG2921	Belongs to the UPF0250 family
THICY_RS06395	COG0321	lipoyl(octanoyl) transferase activity
THICY_RS06400	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
THICY_RS06405	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
THICY_RS06410	COG3022	response to hydroperoxide
THICY_RS06420	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
THICY_RS06425	COG3178	'Phosphotransferase
THICY_RS06430	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
THICY_RS06435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THICY_RS06435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THICY_RS06440	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
THICY_RS06445	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
THICY_RS06450	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
THICY_RS06460	COG0271	Belongs to the BolA IbaG family
THICY_RS06465	COG0633	Ferredoxin
THICY_RS06480	COG0174	glutamine synthetase
THICY_RS06485	COG0815	Transfers the fatty acyl group on membrane lipoproteins
THICY_RS06490	COG4535	Mg2 and Co2 transporter CorC
THICY_RS06500	COG1702	phosphate starvation-inducible protein PhoH
THICY_RS06505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THICY_RS06515	COG0668	transmembrane transport
THICY_RS06525	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THICY_RS06545	COG0415	Belongs to the DNA photolyase family
THICY_RS06565	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
THICY_RS06575	COG0352	thiamine-phosphate diphosphorylase activity
THICY_RS06580	COG0351	phosphomethylpyrimidine kinase
THICY_RS06585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THICY_RS06590	COG0277	FAD linked oxidase domain protein
THICY_RS06600	COG4774	siderophore transport
THICY_RS06600	COG1629	transport
THICY_RS06630	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THICY_RS06635	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
THICY_RS06640	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
THICY_RS06645	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
THICY_RS06655	COG0058	SHG alpha-glucan phosphorylase activity
THICY_RS06660	COG0297	glycogen (starch) synthase activity
THICY_RS06665	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
THICY_RS06680	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
THICY_RS06685	COG0837	glucose binding
THICY_RS06690	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
THICY_RS06695	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
THICY_RS06695	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
THICY_RS06705	COG0517	IMP dehydrogenase activity
THICY_RS06705	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
THICY_RS06710	COG1519	Transferase
THICY_RS06730	COG1620	l-lactate permease
THICY_RS06735	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
THICY_RS06755	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THICY_RS06760	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THICY_RS06765	COG1385	rRNA (uridine-N3-)-methyltransferase activity
THICY_RS06775	COG0745	RESPONSE REGULATOR receiver
THICY_RS06780	COG2205	protein histidine kinase activity
THICY_RS06790	COG1295	ribonuclease BN
THICY_RS06795	COG0793	Belongs to the peptidase S41A family
THICY_RS06800	COG0640	Transcriptional regulator
THICY_RS06810	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THICY_RS06815	COG0772	Belongs to the SEDS family
THICY_RS06820	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
THICY_RS06825	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THICY_RS06830	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
THICY_RS06835	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THICY_RS06850	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
THICY_RS06855	COG0275	rRNA processing
THICY_RS06860	COG2001	Belongs to the MraZ family
THICY_RS06875	COG0792	nuclease activity
THICY_RS06880	COG0783	Belongs to the Dps family
THICY_RS06900	COG1610	YqeY-like protein
THICY_RS06905	COG0828	Belongs to the bacterial ribosomal protein bS21 family
THICY_RS06910	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
THICY_RS06915	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THICY_RS06920	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
THICY_RS06930	COG1968	undecaprenyl-diphosphatase activity
THICY_RS06935	COG2239	Acts as a magnesium transporter
THICY_RS06975	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
THICY_RS06985	COG0012	GTP binding
THICY_RS06990	COG0193	aminoacyl-tRNA hydrolase activity
THICY_RS06995	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
THICY_RS07010	COG0268	Binds directly to 16S ribosomal RNA
THICY_RS07015	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
THICY_RS07020	COG0799	negative regulation of ribosome biogenesis
THICY_RS07025	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
THICY_RS07030	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
THICY_RS07060	COG0495	leucyl-tRNA aminoacylation
THICY_RS07075	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
THICY_RS07085	COG0004	ammonium transporteR
THICY_RS07100	COG0525	valine-tRNA ligase activity
THICY_RS07115	COG4974	Belongs to the 'phage' integrase family
THICY_RS07135	COG2945	thiolester hydrolase activity
THICY_RS07140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THICY_RS07165	COG1304	FMN binding
THICY_RS07170	COG3425	synthase
THICY_RS07190	COG2969	positive regulation of protein catabolic process
THICY_RS07195	COG0625	glutathione transferase activity
THICY_RS07200	COG2246	polysaccharide biosynthetic process
THICY_RS07205	COG0463	Glycosyl transferase, family 2
THICY_RS07210	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
THICY_RS07230	COG0776	regulation of translation
THICY_RS07235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THICY_RS07235	COG0072	phenylalanine-tRNA ligase activity
THICY_RS07240	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
THICY_RS07245	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
THICY_RS07250	COG0291	Belongs to the bacterial ribosomal protein bL35 family
THICY_RS07255	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
THICY_RS07260	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THICY_RS07265	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THICY_RS07270	COG0795	lipopolysaccharide-transporting ATPase activity
THICY_RS07280	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
THICY_RS07295	COG0556	nucleotide-excision repair
THICY_RS07300	COG0436	Aminotransferase
THICY_RS07315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THICY_RS07330	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
THICY_RS07335	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THICY_RS07350	COG1917	Cupin 2, conserved barrel domain protein
THICY_RS07350	COG2169	Transcriptional regulator
THICY_RS07360	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
THICY_RS07375	COG2205	protein histidine kinase activity
THICY_RS07380	COG0745	RESPONSE REGULATOR receiver
THICY_RS07395	COG1309	transcriptional regulator
THICY_RS07405	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THICY_RS07410	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
THICY_RS07435	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THICY_RS07435	COG2111	Na H antiporter
THICY_RS07440	COG1006	Multisubunit Na H antiporter MnhC subunit
THICY_RS07445	COG0651	ATP synthesis coupled electron transport
THICY_RS07455	COG2212	antiporter activity
THICY_RS07460	COG1320	monovalent cation:proton antiporter activity
THICY_RS07470	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
THICY_RS07480	COG1611	Belongs to the LOG family
THICY_RS07485	COG0513	Belongs to the DEAD box helicase family
THICY_RS07505	COG0745	RESPONSE REGULATOR receiver
THICY_RS07510	COG0642	Histidine kinase
THICY_RS07515	COG0585	pseudouridine synthase activity
THICY_RS07525	COG1454	alcohol dehydrogenase
THICY_RS07530	COG0210	DNA helicase
THICY_RS07540	COG1401	restriction endodeoxyribonuclease activity
THICY_RS07565	COG2873	o-acetylhomoserine
THICY_RS07575	COG2813	Specifically methylates the guanine in position
THICY_RS07615	COG0561	phosphatase activity
THICY_RS07620	COG0727	PFAM Uncharacterised protein family (UPF0153)
THICY_RS07650	COG1562	ergosterol biosynthetic process
THICY_RS07660	COG0142	geranyltranstransferase activity
THICY_RS07690	COG0018	arginyl-trna synthetase
THICY_RS07710	COG0758	DNA mediated transformation
THICY_RS07715	COG0242	peptide deformylase activity
THICY_RS07720	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THICY_RS07725	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
THICY_RS07735	COG5000	phosphorelay sensor kinase activity
THICY_RS07740	COG2204	response regulator
THICY_RS07745	COG0569	domain protein
THICY_RS07790	COG3278	Belongs to the heme-copper respiratory oxidase family
THICY_RS07795	COG0131	Imidazoleglycerol-phosphate dehydratase
THICY_RS07800	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
THICY_RS07805	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
THICY_RS07810	COG0107	imidazoleglycerol-phosphate synthase activity
THICY_RS07815	COG0140	phosphoribosyl-ATP diphosphatase activity
THICY_RS07820	COG0537	adenosine 5'-monophosphoramidase activity
THICY_RS07830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THICY_RS07850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THICY_RS07860	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
THICY_RS07865	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
THICY_RS07875	COG0583	DNA-binding transcription factor activity
THICY_RS07905	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
THICY_RS07910	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
THICY_RS07940	COG1850	ribulose-bisphosphate carboxylase activity
THICY_RS07955	COG0596	Alpha beta hydrolase
THICY_RS07960	COG1278	Cold shock
THICY_RS07970	COG0156	8-amino-7-oxononanoate synthase activity
THICY_RS07975	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THICY_RS07980	COG1040	competence protein
THICY_RS07985	COG1929	Belongs to the glycerate kinase type-1 family
THICY_RS07990	COG0366	Alpha amylase catalytic
THICY_RS07995	COG1215	transferase activity, transferring glycosyl groups
THICY_RS08015	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
THICY_RS08020	COG0254	rRNA binding
THICY_RS08025	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
THICY_RS08030	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
THICY_RS08035	COG1194	a g-specific adenine glycosylase
THICY_RS08040	COG0220	tRNA (guanine-N7-)-methyltransferase activity
THICY_RS08060	COG0037	tRNA processing
THICY_RS08065	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THICY_RS08080	COG3609	addiction module antidote protein, CC2985 family
THICY_RS08090	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
THICY_RS08105	COG2022	thiamine diphosphate biosynthetic process
THICY_RS08110	COG1192	Involved in chromosome partitioning
THICY_RS08120	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
THICY_RS08125	COG2353	YceI-like domain
THICY_RS08130	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
THICY_RS08140	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
THICY_RS08145	COG0355	proton-transporting ATP synthase activity, rotational mechanism
THICY_RS08150	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
THICY_RS08155	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
THICY_RS08160	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
THICY_RS08165	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THICY_RS08170	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
THICY_RS08175	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THICY_RS08180	COG0356	it plays a direct role in the translocation of protons across the membrane
THICY_RS08200	COG1192	Involved in chromosome partitioning
THICY_RS08205	COG0357	Ribosomal RNA small subunit methyltransferase G
THICY_RS08210	COG0445	tRNA wobble uridine modification
THICY_RS08220	COG1643	Atp-dependent helicase
THICY_RS08230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
THICY_RS08235	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
THICY_RS08235	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
THICY_RS08240	COG4772	TonB-dependent receptor
THICY_RS08270	COG0181	hydroxymethylbilane synthase activity
THICY_RS08280	COG0165	Argininosuccinate lyase
THICY_RS08295	COG2814	Major facilitator Superfamily
THICY_RS08300	COG0784	Response regulator, receiver
THICY_RS08300	COG5002	protein histidine kinase activity
THICY_RS08310	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
THICY_RS08315	COG0339	signal peptide processing
THICY_RS08320	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
THICY_RS08325	COG0730	response to heat
THICY_RS08330	COG0706	membrane insertase activity
THICY_RS08335	COG0594	ribonuclease P activity
THICY_RS08340	COG0230	Belongs to the bacterial ribosomal protein bL34 family
THICY_RS08345	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THICY_RS08365	COG4191	Histidine kinase
THICY_RS08370	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
THICY_RS08375	COG0408	coproporphyrinogen oxidase activity
THICY_RS08380	COG4783	chaperone-mediated protein folding
THICY_RS08385	COG0218	Necessary for normal cell division and for the maintenance of normal septation
THICY_RS08390	COG1333	cytochrome c biogenesis protein
THICY_RS08395	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
THICY_RS08400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
THICY_RS08410	COG0778	Nitroreductase
THICY_RS08425	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THICY_RS08430	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
THICY_RS08435	COG0009	L-threonylcarbamoyladenylate synthase
THICY_RS08440	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
THICY_RS08450	COG3842	ATPase activity
THICY_RS08460	COG2304	oxidoreductase activity
THICY_RS08480	COG0714	Associated with various cellular activities
THICY_RS08485	COG0500	methyltransferase
THICY_RS08490	COG2226	methyltransferase
THICY_RS08495	COG0583	DNA-binding transcription factor activity
THICY_RS08500	COG1741	Belongs to the pirin family
THICY_RS08510	COG0741	lytic transglycosylase activity
THICY_RS08535	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THICY_RS08570	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
THICY_RS08570	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
THICY_RS08580	COG1714	RDD family
THICY_RS08585	COG1401	restriction endodeoxyribonuclease activity
THICY_RS08595	COG0746	molybdenum cofactor guanylyltransferase activity
THICY_RS08600	COG0500	methyltransferase
THICY_RS08620	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
THICY_RS08640	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
THICY_RS08650	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THICY_RS08685	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
THICY_RS08715	COG4681	YaeQ
THICY_RS08720	COG3530	Putative quorum-sensing-regulated virulence factor