locus-tag	class	description
TINT_RS00015	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TINT_RS00020	COG0592	DNA-directed DNA polymerase activity
TINT_RS00035	COG3383	formate dehydrogenase (NAD+) activity
TINT_RS00040	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TINT_RS00045	COG0837	glucose binding
TINT_RS00055	COG0800	Aldolase
TINT_RS00070	COG1294	oxidase, subunit
TINT_RS00075	COG1271	oxidase subunit
TINT_RS00085	COG1230	cation diffusion facilitator family transporter
TINT_RS00115	COG0752	glycyl-tRNA synthetase alpha subunit
TINT_RS00120	COG0751	glycine-tRNA ligase activity
TINT_RS00125	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TINT_RS00145	COG0346	lactoylglutathione lyase activity
TINT_RS00165	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TINT_RS00175	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TINT_RS00185	COG0735	belongs to the Fur family
TINT_RS00190	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TINT_RS00220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TINT_RS00245	COG2391	methyltransferase activity
TINT_RS00250	COG2391	methyltransferase activity
TINT_RS00260	COG2204	response regulator
TINT_RS00270	COG2205	protein histidine kinase activity
TINT_RS00275	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TINT_RS00280	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
TINT_RS00300	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
TINT_RS00305	COG4988	ABC transporter
TINT_RS00330	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TINT_RS00335	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
TINT_RS00340	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
TINT_RS00345	COG2205	protein histidine kinase activity
TINT_RS00350	COG0745	RESPONSE REGULATOR receiver
TINT_RS00365	COG2814	Major facilitator Superfamily
TINT_RS00380	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TINT_RS00385	COG0739	heme binding
TINT_RS00390	COG0739	heme binding
TINT_RS00395	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
TINT_RS00405	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TINT_RS00410	COG1862	Preprotein translocase
TINT_RS00415	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TINT_RS00420	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TINT_RS00430	COG2922	Belongs to the Smg family
TINT_RS00435	COG0758	DNA mediated transformation
TINT_RS00445	COG0242	peptide deformylase activity
TINT_RS00450	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TINT_RS00455	COG0501	Belongs to the peptidase M48B family
TINT_RS00460	COG1950	PFAM Membrane protein of
TINT_RS00470	COG0625	glutathione transferase activity
TINT_RS00480	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TINT_RS00490	COG0280	phosphate acetyltransferase
TINT_RS00490	COG0281	malic enzyme
TINT_RS00505	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TINT_RS00510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TINT_RS00515	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
TINT_RS00520	COG3178	'Phosphotransferase
TINT_RS00530	COG0006	proline dipeptidase activity
TINT_RS00545	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TINT_RS00555	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TINT_RS00560	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TINT_RS00580	COG1850	ribulose-bisphosphate carboxylase activity
TINT_RS00610	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TINT_RS00615	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TINT_RS00620	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TINT_RS00625	COG2193	ferroxidase activity
TINT_RS00635	COG1192	Involved in chromosome partitioning
TINT_RS00655	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TINT_RS00670	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TINT_RS00675	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TINT_RS00680	COG0583	DNA-binding transcription factor activity
TINT_RS00685	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
TINT_RS00690	COG3954	Phosphoribulokinase
TINT_RS00695	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TINT_RS00700	COG0546	phosphoglycolate phosphatase activity
TINT_RS00705	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TINT_RS00710	COG0126	phosphoglycerate kinase activity
TINT_RS00715	COG0191	fructose-bisphosphate aldolase activity
TINT_RS00725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TINT_RS00735	COG1466	dna polymerase III delta subunit
TINT_RS00745	COG0495	leucyl-tRNA aminoacylation
TINT_RS00750	COG1252	NADH dehydrogenase
TINT_RS00760	COG1228	amidohydrolase
TINT_RS00775	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TINT_RS00785	COG0154	amidase activity
TINT_RS00790	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TINT_RS00795	COG1077	Cell shape determining protein MreB Mrl
TINT_RS00800	COG1792	Involved in formation and maintenance of cell shape
TINT_RS00810	COG0768	penicillin binding
TINT_RS00815	COG0772	Belongs to the SEDS family
TINT_RS00845	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TINT_RS00850	COG0010	Belongs to the arginase family
TINT_RS00855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TINT_RS00880	COG0410	ABC transporter
TINT_RS00890	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TINT_RS00895	COG0174	glutamine synthetase
TINT_RS00905	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TINT_RS00910	COG3842	ATPase activity
TINT_RS00915	COG1176	ABC-type spermidine putrescine transport system, permease component I
TINT_RS00920	COG1177	transmembrane transport
TINT_RS00935	COG1012	belongs to the aldehyde dehydrogenase family
TINT_RS00940	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TINT_RS00945	COG0300	oxidoreductase activity
TINT_RS00955	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
TINT_RS00985	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TINT_RS00985	COG2755	lipolytic protein G-D-S-L family
TINT_RS01005	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TINT_RS01005	COG2813	Specifically methylates the guanine in position
TINT_RS01010	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TINT_RS01015	COG1120	ATPase activity
TINT_RS01020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TINT_RS01065	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TINT_RS01085	COG0157	Belongs to the NadC ModD family
TINT_RS01105	COG1278	Cold shock
TINT_RS01115	COG2255	four-way junction helicase activity
TINT_RS01150	COG1289	transmembrane transporter activity
TINT_RS01160	COG2814	Major facilitator Superfamily
TINT_RS01165	COG1566	PFAM secretion protein HlyD family protein
TINT_RS01170	COG1538	Outer membrane efflux protein
TINT_RS01195	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TINT_RS01200	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TINT_RS01205	COG1294	oxidase, subunit
TINT_RS01210	COG1271	oxidase subunit
TINT_RS01225	COG1846	Transcriptional regulator
TINT_RS01230	COG3038	cytochrome b561
TINT_RS01250	COG1960	acyl-CoA dehydrogenase activity
TINT_RS01260	COG3706	GGDEF domain
TINT_RS01265	COG0443	Heat shock 70 kDa protein
TINT_RS01270	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
TINT_RS01285	COG0463	Glycosyl transferase, family 2
TINT_RS01285	COG1216	Glycosyl transferase, family 2
TINT_RS01290	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TINT_RS01315	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TINT_RS01320	COG0343	queuine tRNA-ribosyltransferase activity
TINT_RS01330	COG1487	ribonuclease activity
TINT_RS01340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TINT_RS01385	COG1054	Belongs to the UPF0176 family
TINT_RS01395	COG3258	Cytochrome c
TINT_RS01410	COG1872	DUF167
TINT_RS01420	COG0651	ATP synthesis coupled electron transport
TINT_RS01425	COG0650	Formate hydrogenlyase subunit 4
TINT_RS01435	COG0651	ATP synthesis coupled electron transport
TINT_RS01440	COG0649	NAD binding
TINT_RS01445	COG3260	NADH ubiquinone oxidoreductase 20
TINT_RS01470	COG1981	membrane
TINT_RS01490	COG1686	Belongs to the peptidase S11 family
TINT_RS01495	COG0675	Transposase, IS605 OrfB family
TINT_RS01505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TINT_RS01520	COG1024	Enoyl-CoA hydratase
TINT_RS01530	COG0675	Transposase, IS605 OrfB family
TINT_RS01535	COG2200	EAL domain
TINT_RS01535	COG2199	diguanylate cyclase activity
TINT_RS01545	COG0675	Transposase, IS605 OrfB family
TINT_RS01555	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TINT_RS01595	COG0529	Catalyzes the synthesis of activated sulfate
TINT_RS01595	COG2895	sulfate adenylyltransferase (ATP) activity
TINT_RS01600	COG0175	sulfate reduction
TINT_RS01615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TINT_RS01635	COG1215	transferase activity, transferring glycosyl groups
TINT_RS01655	COG0513	Belongs to the DEAD box helicase family
TINT_RS01665	COG0675	Transposase, IS605 OrfB family
TINT_RS01675	COG2002	toxin-antitoxin pair type II binding
TINT_RS01680	COG0488	(ABC) transporter
TINT_RS01690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TINT_RS01695	COG1254	Belongs to the acylphosphatase family
TINT_RS01730	COG1194	a g-specific adenine glycosylase
TINT_RS01735	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
TINT_RS01740	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TINT_RS01755	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TINT_RS01765	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TINT_RS01770	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TINT_RS01780	COG5265	(ABC) transporter
TINT_RS01785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TINT_RS01790	COG0765	amino acid transport
TINT_RS01795	COG0765	amino acid transport
TINT_RS01800	COG1126	abc transporter atp-binding protein
TINT_RS01805	COG0418	dihydroorotase activity
TINT_RS01815	COG2001	Belongs to the MraZ family
TINT_RS01820	COG0275	rRNA processing
TINT_RS01835	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TINT_RS01840	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TINT_RS01845	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TINT_RS01850	COG0772	Belongs to the SEDS family
TINT_RS01855	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TINT_RS01860	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TINT_RS01865	COG1181	Belongs to the D-alanine--D-alanine ligase family
TINT_RS01870	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TINT_RS01880	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TINT_RS01885	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TINT_RS01895	COG0653	protein targeting
TINT_RS01910	COG0494	nUDIX hydrolase
TINT_RS01915	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
TINT_RS01920	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
TINT_RS01925	COG0237	dephospho-CoA kinase activity
TINT_RS01950	COG0582	viral genome integration into host DNA
TINT_RS02025	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TINT_RS02030	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TINT_RS02050	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TINT_RS02055	COG0670	Belongs to the BI1 family
TINT_RS02060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TINT_RS02065	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TINT_RS02115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TINT_RS02130	COG0215	cysteine-tRNA ligase activity
TINT_RS02140	COG0825	malonyl-CoA metabolic process
TINT_RS02145	COG0037	tRNA processing
TINT_RS02170	COG3039	Transposase
TINT_RS02175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TINT_RS02180	COG1131	(ABC) transporter
TINT_RS02185	COG1131	(ABC) transporter
TINT_RS02190	COG0842	Transport permease protein
TINT_RS02195	COG0842	Transport permease protein
TINT_RS02210	COG0574	Belongs to the PEP-utilizing enzyme family
TINT_RS02210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TINT_RS02220	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TINT_RS02230	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TINT_RS02235	COG0022	dehydrogenase e1 component
TINT_RS02235	COG0508	dehydrogenase complex catalyzes the overall conversion of
TINT_RS02240	COG0508	dehydrogenase complex catalyzes the overall conversion of
TINT_RS02260	COG0148	phosphopyruvate hydratase activity
TINT_RS02295	COG3245	cytochrome
TINT_RS02325	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TINT_RS02370	COG0792	nuclease activity
TINT_RS02375	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TINT_RS02380	COG2823	Periplasmic or secreted lipoprotein
TINT_RS02385	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TINT_RS02390	COG2084	Dehydrogenase
TINT_RS02420	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TINT_RS02455	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TINT_RS02465	COG0850	regulation of cytokinetic process
TINT_RS02470	COG1136	(ABC) transporter
TINT_RS02480	COG0659	secondary active sulfate transmembrane transporter activity
TINT_RS02485	COG1086	Polysaccharide biosynthesis protein
TINT_RS02490	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TINT_RS02500	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TINT_RS02550	COG4584	PFAM Integrase catalytic
TINT_RS02575	COG0142	geranyltranstransferase activity
TINT_RS02580	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TINT_RS02585	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TINT_RS02590	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TINT_RS02595	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TINT_RS02605	COG0494	nUDIX hydrolase
TINT_RS02610	COG0442	prolyl-tRNA aminoacylation
TINT_RS02615	COG0741	lytic transglycosylase activity
TINT_RS02620	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TINT_RS02645	COG3023	N-Acetylmuramoyl-L-alanine amidase
TINT_RS02650	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TINT_RS02650	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TINT_RS02665	COG0717	Belongs to the dCTP deaminase family
TINT_RS02670	COG0165	Argininosuccinate lyase
TINT_RS02675	COG3275	phosphorelay sensor kinase activity
TINT_RS02685	COG1968	undecaprenyl-diphosphatase activity
TINT_RS02710	COG1573	uracil-dna glycosylase
TINT_RS02740	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TINT_RS02750	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
TINT_RS02755	COG3300	MHYT domain
TINT_RS02755	COG5001	Diguanylate cyclase
TINT_RS02760	COG3300	MHYT domain
TINT_RS02760	COG5001	Diguanylate cyclase
TINT_RS02770	COG0477	Major facilitator Superfamily
TINT_RS02780	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
TINT_RS02785	COG2814	Major facilitator Superfamily
TINT_RS02800	COG1522	sequence-specific DNA binding
TINT_RS02805	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TINT_RS02830	COG4689	acetoacetate decarboxylase
TINT_RS02835	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TINT_RS02840	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TINT_RS02900	COG1473	amidohydrolase
TINT_RS02905	COG4636	protein conserved in cyanobacteria
TINT_RS02915	COG2852	Protein conserved in bacteria
TINT_RS02980	COG4178	(ABC) transporter
TINT_RS02985	COG3945	hemerythrin HHE cation binding domain
TINT_RS03000	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TINT_RS03010	COG0668	transmembrane transport
TINT_RS03015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TINT_RS03020	COG3300	MHYT domain
TINT_RS03020	COG5001	Diguanylate cyclase
TINT_RS03035	COG0247	lactate metabolic process
TINT_RS03040	COG0277	FAD linked oxidase domain protein
TINT_RS03045	COG0277	FAD linked oxidase domain protein
TINT_RS03055	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TINT_RS03070	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TINT_RS03075	COG0583	DNA-binding transcription factor activity
TINT_RS03080	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TINT_RS03085	COG3002	Belongs to the UPF0753 family
TINT_RS03095	COG2329	Antibiotic biosynthesis monooxygenase
TINT_RS03100	COG4221	oxidoreductase activity
TINT_RS03115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TINT_RS03130	COG2096	Adenosyltransferase
TINT_RS03140	COG0277	FAD linked oxidase domain protein
TINT_RS03160	COG4636	protein conserved in cyanobacteria
TINT_RS03200	COG2165	general secretion pathway protein
TINT_RS03235	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TINT_RS03240	COG0459	protein refolding
TINT_RS03260	COG1752	Esterase of the alpha-beta hydrolase superfamily
TINT_RS03265	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TINT_RS03275	COG1333	cytochrome c biogenesis protein
TINT_RS03280	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TINT_RS03285	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TINT_RS03290	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
TINT_RS03300	COG1965	Belongs to the frataxin family
TINT_RS03340	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TINT_RS03345	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TINT_RS03370	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TINT_RS03385	COG1028	Short-chain dehydrogenase reductase Sdr
TINT_RS03390	COG0642	Histidine kinase
TINT_RS03420	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
TINT_RS03425	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TINT_RS03435	COG0625	glutathione transferase activity
TINT_RS03445	COG1024	Enoyl-CoA hydratase
TINT_RS03455	COG0513	Belongs to the DEAD box helicase family
TINT_RS03485	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
TINT_RS03500	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TINT_RS03505	COG0318	PFAM AMP-dependent synthetase and ligase
TINT_RS03570	COG0259	pyridoxamine-phosphate oxidase activity
TINT_RS03595	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TINT_RS03605	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TINT_RS03610	COG0741	lytic transglycosylase activity
TINT_RS03615	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TINT_RS03640	COG1280	lysine exporter protein (LysE YggA)
TINT_RS03660	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
TINT_RS03675	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TINT_RS03680	COG0793	Belongs to the peptidase S41A family
TINT_RS03685	COG0588	phosphoglycerate mutase activity
TINT_RS03690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TINT_RS03695	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
TINT_RS03700	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
TINT_RS03705	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TINT_RS03710	COG0193	aminoacyl-tRNA hydrolase activity
TINT_RS03720	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TINT_RS03725	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TINT_RS03730	COG0742	ribosomal rna small subunit methyltransferase
TINT_RS03755	COG2814	Major facilitator Superfamily
TINT_RS03765	COG0714	Associated with various cellular activities
TINT_RS03800	COG2921	Belongs to the UPF0250 family
TINT_RS03805	COG2900	Belongs to the SlyX family
TINT_RS03820	COG2132	Multicopper oxidase
TINT_RS03835	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TINT_RS03850	COG0714	Associated with various cellular activities
TINT_RS03855	COG0123	including yeast histone deacetylase and acetoin utilization protein
TINT_RS03885	COG1012	belongs to the aldehyde dehydrogenase family
TINT_RS03895	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TINT_RS03900	COG0756	dUTP diphosphatase activity
TINT_RS03910	COG1047	Peptidyl-prolyl cis-trans
TINT_RS03915	COG2850	peptidyl-arginine hydroxylation
TINT_RS03930	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
TINT_RS03935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TINT_RS03945	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TINT_RS03950	COG0783	Belongs to the Dps family
TINT_RS03955	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TINT_RS03960	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TINT_RS03965	COG0693	protein deglycase activity
TINT_RS03970	COG3118	belongs to the thioredoxin family
TINT_RS03975	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TINT_RS03980	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TINT_RS03985	COG0009	L-threonylcarbamoyladenylate synthase
TINT_RS04000	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TINT_RS04005	COG2137	regulation of response to DNA damage stimulus
TINT_RS04015	COG0045	succinate-CoA ligase (ADP-forming) activity
TINT_RS04020	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TINT_RS04025	COG0861	Integral membrane protein TerC family
TINT_RS04030	COG0631	protein serine/threonine phosphatase activity
TINT_RS04040	COG0469	pyruvate kinase activity
TINT_RS04060	COG3307	-O-antigen
TINT_RS04070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TINT_RS04100	COG0765	amino acid transport
TINT_RS04105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TINT_RS04110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TINT_RS04130	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TINT_RS04155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TINT_RS04175	COG1937	Protein conserved in bacteria
TINT_RS04180	COG0482	sulfurtransferase activity
TINT_RS04185	COG1051	belongs to the nudix hydrolase family
TINT_RS04260	COG1127	ABC transporter
TINT_RS04265	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TINT_RS04270	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TINT_RS04275	COG2853	Lipoprotein
TINT_RS04290	COG1131	(ABC) transporter
TINT_RS04295	COG0842	Transport permease protein
TINT_RS04305	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TINT_RS04310	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TINT_RS04315	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TINT_RS04320	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TINT_RS04325	COG0131	Imidazoleglycerol-phosphate dehydratase
TINT_RS04335	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TINT_RS04340	COG0107	imidazoleglycerol-phosphate synthase activity
TINT_RS04345	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TINT_RS04345	COG0140	phosphoribosyl-ATP diphosphatase activity
TINT_RS04355	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TINT_RS04360	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TINT_RS04365	COG0805	protein transport
TINT_RS04370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TINT_RS04375	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TINT_RS04380	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TINT_RS04385	COG0489	protein tyrosine kinase activity
TINT_RS04395	COG1105	Belongs to the carbohydrate kinase PfkB family
TINT_RS04400	COG0151	Belongs to the GarS family
TINT_RS04405	COG0217	transcriptional regulatory protein
TINT_RS04410	COG0433	COG0433 Predicted ATPase
TINT_RS04420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TINT_RS04440	COG2223	nitrite transmembrane transporter activity
TINT_RS04445	COG1272	protein, Hemolysin III
TINT_RS04475	COG0778	Nitroreductase
TINT_RS04495	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TINT_RS04500	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TINT_RS04505	COG2867	negative regulation of translational initiation
TINT_RS04510	COG2914	Belongs to the UPF0125 (RnfH) family
TINT_RS04535	COG0683	leucine binding
TINT_RS04545	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TINT_RS04550	COG0415	Belongs to the DNA photolyase family
TINT_RS04555	COG3046	protein related to deoxyribodipyrimidine photolyase
TINT_RS04565	COG1028	Short-chain dehydrogenase reductase Sdr
TINT_RS04575	COG3706	GGDEF domain
TINT_RS04610	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TINT_RS04615	COG2233	PERMEase
TINT_RS04625	COG0303	'Molybdopterin
TINT_RS04630	COG0746	molybdenum cofactor guanylyltransferase activity
TINT_RS04645	COG0728	peptidoglycan biosynthetic process
TINT_RS04650	COG0268	Binds directly to 16S ribosomal RNA
TINT_RS04660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TINT_RS04665	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TINT_RS04680	COG1162	GTPase activity
TINT_RS04685	COG2154	pterin-4-alpha-carbinolamine dehydratase
TINT_RS04690	COG0501	Belongs to the peptidase M48B family
TINT_RS04695	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
TINT_RS04710	COG2226	methyltransferase
TINT_RS04715	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TINT_RS04720	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TINT_RS04740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TINT_RS04745	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TINT_RS04750	COG1914	H( )-stimulated, divalent metal cation uptake system
TINT_RS04760	COG1968	undecaprenyl-diphosphatase activity
TINT_RS04785	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TINT_RS04805	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TINT_RS04815	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TINT_RS04820	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TINT_RS04835	COG0004	ammonium transporteR
TINT_RS04885	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
TINT_RS04890	COG0848	biopolymer transport protein
TINT_RS04895	COG0811	peptide transport
TINT_RS04915	COG0859	PFAM glycosyl transferase family 9
TINT_RS04930	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TINT_RS04930	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TINT_RS04935	COG1289	transmembrane transporter activity
TINT_RS04940	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TINT_RS04950	COG0483	inositol monophosphate 1-phosphatase activity
TINT_RS04960	COG1045	serine acetyltransferase
TINT_RS04970	COG0840	transmembrane signaling receptor activity
TINT_RS04985	COG1522	sequence-specific DNA binding
TINT_RS04990	COG3483	tryptophan 2,3-dioxygenase activity
TINT_RS05000	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TINT_RS05010	COG3186	Phenylalanine-4-hydroxylase
TINT_RS05015	COG0625	glutathione transferase activity
TINT_RS05075	COG0084	hydrolase, TatD family'
TINT_RS05080	COG0326	Molecular chaperone. Has ATPase activity
TINT_RS05095	COG0335	large ribosomal subunit rRNA binding
TINT_RS05100	COG0336	Belongs to the RNA methyltransferase TrmD family
TINT_RS05105	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TINT_RS05110	COG0228	four-way junction DNA binding
TINT_RS05125	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TINT_RS05130	COG0617	tRNA 3'-terminal CCA addition
TINT_RS05140	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TINT_RS05145	COG0628	permease
TINT_RS05150	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TINT_RS05155	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TINT_RS05165	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
TINT_RS05170	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TINT_RS05175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TINT_RS05180	COG0477	Major facilitator Superfamily
TINT_RS05185	COG0516	GMP reductase activity
TINT_RS05190	COG0210	DNA helicase
TINT_RS05200	COG0492	ferredoxin-NADP+ reductase activity
TINT_RS05205	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TINT_RS05220	COG0640	Transcriptional regulator
TINT_RS05230	COG2183	response to ionizing radiation
TINT_RS05235	COG0542	response to heat
TINT_RS05245	COG1999	signal sequence binding
TINT_RS05260	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TINT_RS05270	COG0709	Synthesizes selenophosphate from selenide and ATP
TINT_RS05275	COG0583	DNA-binding transcription factor activity
TINT_RS05280	COG1959	2 iron, 2 sulfur cluster binding
TINT_RS05285	COG1104	cysteine desulfurase activity
TINT_RS05290	COG0822	iron-sulfur transferase activity
TINT_RS05300	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
TINT_RS05305	COG0443	Heat shock 70 kDa protein
TINT_RS05310	COG0633	Ferredoxin
TINT_RS05325	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
TINT_RS05330	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TINT_RS05330	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TINT_RS05335	COG1643	Atp-dependent helicase
TINT_RS05350	COG3278	Belongs to the heme-copper respiratory oxidase family
TINT_RS05380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TINT_RS05420	COG4584	PFAM Integrase catalytic
TINT_RS05435	COG3039	Transposase
TINT_RS05460	COG0166	Belongs to the GPI family
TINT_RS05465	COG0058	SHG alpha-glucan phosphorylase activity
TINT_RS05470	COG0297	glycogen (starch) synthase activity
TINT_RS05480	COG0033	Phosphoglucomutase
TINT_RS05485	COG1523	belongs to the glycosyl hydrolase 13 family
TINT_RS05500	COG0363	glucosamine-6-phosphate deaminase activity
TINT_RS05505	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TINT_RS05510	COG2030	dehydratase
TINT_RS05530	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TINT_RS05540	COG1573	uracil-dna glycosylase
TINT_RS05545	COG0322	excinuclease ABC activity
TINT_RS05585	COG1611	Belongs to the LOG family
TINT_RS05590	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TINT_RS05605	COG1136	(ABC) transporter
TINT_RS05620	COG1309	transcriptional regulator
TINT_RS05660	COG0473	3-isopropylmalate dehydrogenase activity
TINT_RS05675	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TINT_RS05730	COG0582	viral genome integration into host DNA
TINT_RS05735	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TINT_RS05745	COG3243	poly(R)-hydroxyalkanoic acid synthase
TINT_RS05775	COG1987	bacterial-type flagellum assembly
TINT_RS05810	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TINT_RS05825	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TINT_RS05840	COG4453	Protein conserved in bacteria
TINT_RS05850	COG0840	transmembrane signaling receptor activity
TINT_RS05855	COG0784	Response regulator, receiver
TINT_RS05855	COG0835	chemotaxis
TINT_RS05880	COG0643	Histidine kinase
TINT_RS05880	COG2198	Histidine kinase
TINT_RS05895	COG5001	Diguanylate cyclase
TINT_RS05915	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
TINT_RS05925	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
TINT_RS05930	COG1216	Glycosyl transferase, family 2
TINT_RS05930	COG0438	transferase activity, transferring glycosyl groups
TINT_RS05940	COG1256	bacterial-type flagellum assembly
TINT_RS05950	COG1705	Flagellar rod assembly protein muramidase FlgJ
TINT_RS05950	COG3951	Flagellar rod assembly protein muramidase FlgJ
TINT_RS05955	COG1706	bacterial-type flagellum-dependent cell motility
TINT_RS05960	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TINT_RS05985	COG1558	bacterial-type flagellum-dependent cell motility
TINT_RS05990	COG1815	bacterial-type flagellum-dependent cell motility
TINT_RS06040	COG1516	flagellar protein fliS
TINT_RS06070	COG1677	Flagellar hook-basal body complex protein FliE
TINT_RS06120	COG0840	transmembrane signaling receptor activity
TINT_RS06125	COG2201	protein-glutamate methylesterase activity
TINT_RS06130	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TINT_RS06155	COG0840	transmembrane signaling receptor activity
TINT_RS06175	COG0745	RESPONSE REGULATOR receiver
TINT_RS06180	COG0840	transmembrane signaling receptor activity
TINT_RS06190	COG2197	response regulator
TINT_RS06200	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TINT_RS06205	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TINT_RS06210	COG0586	Pfam SNARE associated Golgi protein
TINT_RS06215	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TINT_RS06220	COG0252	asparaginase activity
TINT_RS06230	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
TINT_RS06265	COG0667	Aldo Keto reductase
TINT_RS06275	COG0655	NAD(P)H dehydrogenase (quinone) activity
TINT_RS06290	COG0583	DNA-binding transcription factor activity
TINT_RS06300	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TINT_RS06315	COG2022	thiamine diphosphate biosynthetic process
TINT_RS06335	COG4251	negative regulation of phosphorylation
TINT_RS06335	COG2203	Gaf domain
TINT_RS06335	COG5001	Diguanylate cyclase
TINT_RS06335	COG3706	GGDEF domain
TINT_RS06360	COG2132	Multicopper oxidase
TINT_RS06370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TINT_RS06415	COG0318	PFAM AMP-dependent synthetase and ligase
TINT_RS06430	COG4166	transmembrane transport
TINT_RS06435	COG4174	ABC transporter (Permease)
TINT_RS06440	COG4239	(ABC) transporter, permease
TINT_RS06445	COG4172	Belongs to the ABC transporter superfamily
TINT_RS06450	COG0779	Required for maturation of 30S ribosomal subunits
TINT_RS06455	COG2251	uridine kinase activity
TINT_RS06455	COG0195	Participates in both transcription termination and antitermination
TINT_RS06460	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TINT_RS06465	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TINT_RS06470	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TINT_RS06495	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TINT_RS06505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TINT_RS06510	COG1902	pentaerythritol trinitrate reductase activity
TINT_RS06520	COG0243	molybdopterin cofactor binding
TINT_RS06525	COG0437	4 iron, 4 sulfur cluster binding
TINT_RS06530	COG3302	dmso reductase anchor subunit
TINT_RS06550	COG1199	ATP-dependent helicase activity
TINT_RS06560	COG0564	pseudouridine synthase activity
TINT_RS06565	COG0463	Glycosyl transferase, family 2
TINT_RS06575	COG3243	poly(R)-hydroxyalkanoic acid synthase
TINT_RS06580	COG0183	Belongs to the thiolase family
TINT_RS06585	COG1028	Short-chain dehydrogenase reductase Sdr
TINT_RS06595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TINT_RS06605	COG0730	response to heat
TINT_RS06610	COG1584	GPR1 FUN34 yaaH family protein
TINT_RS06635	COG0708	Exodeoxyribonuclease III
TINT_RS06640	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TINT_RS06645	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TINT_RS06650	COG0196	riboflavin kinase activity
TINT_RS06655	COG1278	Cold shock
TINT_RS06660	COG0586	Pfam SNARE associated Golgi protein
TINT_RS06665	COG0180	Tryptophanyl-tRNA synthetase
TINT_RS06670	COG1994	Peptidase M50
TINT_RS06675	COG0009	L-threonylcarbamoyladenylate synthase
TINT_RS06680	COG0613	PHP domain protein
TINT_RS06690	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TINT_RS06700	COG1666	GTP binding
TINT_RS06705	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TINT_RS06715	COG0242	peptide deformylase activity
TINT_RS06730	COG0567	Dehydrogenase, E1 component
TINT_RS06735	COG0508	dehydrogenase complex catalyzes the overall conversion of
TINT_RS06740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TINT_RS06745	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
TINT_RS06755	COG0668	transmembrane transport
TINT_RS06760	COG0318	PFAM AMP-dependent synthetase and ligase
TINT_RS06775	COG1960	acyl-CoA dehydrogenase activity
TINT_RS06790	COG1295	ribonuclease BN
TINT_RS06805	COG0277	FAD linked oxidase domain protein
TINT_RS06810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TINT_RS06815	COG0582	viral genome integration into host DNA
TINT_RS06830	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TINT_RS06860	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TINT_RS06870	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TINT_RS06875	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TINT_RS06885	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TINT_RS06890	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TINT_RS06895	COG0072	phenylalanine-tRNA ligase activity
TINT_RS06895	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TINT_RS06900	COG0776	regulation of translation
TINT_RS06915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TINT_RS06920	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TINT_RS06920	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TINT_RS06935	COG2224	Isocitrate lyase
TINT_RS06945	COG0477	Major facilitator Superfamily
TINT_RS06960	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
TINT_RS06965	COG0133	tryptophan synthase activity
TINT_RS06970	COG1132	(ABC) transporter
TINT_RS06980	COG0739	heme binding
TINT_RS06985	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TINT_RS06995	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TINT_RS07000	COG0542	response to heat
TINT_RS07055	COG0582	viral genome integration into host DNA
TINT_RS07085	COG1477	protein flavinylation
TINT_RS07095	COG2890	protein-(glutamine-N5) methyltransferase activity
TINT_RS07100	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TINT_RS07110	COG0318	PFAM AMP-dependent synthetase and ligase
TINT_RS07120	COG0174	glutamine synthetase
TINT_RS07130	COG3852	Histidine kinase
TINT_RS07150	COG1120	ATPase activity
TINT_RS07155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TINT_RS07160	COG0129	dihydroxy-acid dehydratase activity
TINT_RS07165	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TINT_RS07195	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TINT_RS07200	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TINT_RS07205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TINT_RS07210	COG0271	Belongs to the BolA IbaG family
TINT_RS07215	COG2917	probably involved in intracellular septation
TINT_RS07220	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TINT_RS07255	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
TINT_RS07275	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
TINT_RS07280	COG0024	Methionine aminopeptidase
TINT_RS07285	COG0047	phosphoribosylformylglycinamidine synthase activity
TINT_RS07285	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TINT_RS07305	COG1959	2 iron, 2 sulfur cluster binding
TINT_RS07320	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TINT_RS07325	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TINT_RS07330	COG1999	signal sequence binding
TINT_RS07370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TINT_RS07375	COG1522	sequence-specific DNA binding
TINT_RS07380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TINT_RS07390	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TINT_RS07395	COG0657	acetylesterase activity
TINT_RS07405	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TINT_RS07410	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TINT_RS07425	COG0084	hydrolase, TatD family'
TINT_RS07445	COG0330	HflC and HflK could
TINT_RS07450	COG2833	Protein of unknown function (DUF455)
TINT_RS07470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TINT_RS07475	COG2095	MarC family integral membrane protein
TINT_RS07480	COG4974	Belongs to the 'phage' integrase family
TINT_RS07490	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
TINT_RS07495	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TINT_RS07500	COG1940	carbohydrate kinase activity
TINT_RS07505	COG2963	transposase activity
TINT_RS07520	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TINT_RS07530	COG1196	nuclear chromosome segregation
TINT_RS07535	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TINT_RS07540	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TINT_RS07575	COG0438	transferase activity, transferring glycosyl groups
TINT_RS07585	COG0438	transferase activity, transferring glycosyl groups
TINT_RS07590	COG1434	Gram-negative-bacterium-type cell wall biogenesis
TINT_RS07595	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TINT_RS07600	COG0546	phosphoglycolate phosphatase activity
TINT_RS07620	COG4372	Transposase
TINT_RS07665	COG2189	Belongs to the N(4) N(6)-methyltransferase family
TINT_RS07680	COG3550	peptidyl-serine autophosphorylation
TINT_RS07700	COG0582	viral genome integration into host DNA
TINT_RS07745	COG1002	Type II restriction enzyme, methylase subunits
TINT_RS07760	COG1061	Type III restriction enzyme res subunit
TINT_RS07765	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TINT_RS07800	COG0582	viral genome integration into host DNA
TINT_RS07810	COG1484	DNA-dependent DNA replication
TINT_RS07815	COG4584	PFAM Integrase catalytic
TINT_RS07830	COG4584	PFAM Integrase catalytic
TINT_RS07865	COG0559	Belongs to the binding-protein-dependent transport system permease family
TINT_RS07875	COG2015	COG2015, Alkyl sulfatase and related hydrolases
TINT_RS07900	COG1484	DNA-dependent DNA replication
TINT_RS07905	COG4584	PFAM Integrase catalytic
TINT_RS07930	COG0435	Glutathione S-transferase
TINT_RS07935	COG0523	cobalamin synthesis protein
TINT_RS07940	COG1228	amidohydrolase
TINT_RS07950	COG0318	PFAM AMP-dependent synthetase and ligase
TINT_RS07970	COG2130	NADP-dependent
TINT_RS07975	COG1028	Short-chain dehydrogenase reductase Sdr
TINT_RS07980	COG1960	acyl-CoA dehydrogenase activity
TINT_RS07985	COG0183	Belongs to the thiolase family
TINT_RS07990	COG1024	Enoyl-CoA hydratase
TINT_RS07990	COG1250	3-hydroxyacyl-CoA dehydrogenase
TINT_RS07995	COG2045	Belongs to the ComB family
TINT_RS08000	COG0596	Alpha beta hydrolase
TINT_RS08015	COG1960	acyl-CoA dehydrogenase activity
TINT_RS08030	COG1028	Short-chain dehydrogenase reductase Sdr
TINT_RS08060	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TINT_RS08065	COG1469	GTP cyclohydrolase I activity
TINT_RS08070	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TINT_RS08075	COG1121	(ABC) transporter
TINT_RS08085	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TINT_RS08090	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TINT_RS08095	COG0142	geranyltranstransferase activity
TINT_RS08100	COG1722	exodeoxyribonuclease VII activity
TINT_RS08125	COG0412	Dienelactone hydrolase
TINT_RS08140	COG1741	Belongs to the pirin family
TINT_RS08150	COG1079	Belongs to the binding-protein-dependent transport system permease family
TINT_RS08155	COG4603	Belongs to the binding-protein-dependent transport system permease family
TINT_RS08160	COG1129	ABC transporter
TINT_RS08165	COG0402	S-adenosylhomocysteine deaminase activity
TINT_RS08170	COG2252	PERMEase
TINT_RS08185	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TINT_RS08195	COG0129	dihydroxy-acid dehydratase activity
TINT_RS08200	COG0583	DNA-binding transcription factor activity
TINT_RS08210	COG2963	transposase activity
TINT_RS08245	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TINT_RS08250	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TINT_RS08260	COG2003	Belongs to the UPF0758 family
TINT_RS08275	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
TINT_RS08290	COG1850	ribulose-bisphosphate carboxylase activity
TINT_RS08315	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TINT_RS08320	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TINT_RS08325	COG0740	serine-type endopeptidase activity
TINT_RS08330	COG0544	peptidyl-prolyl cis-trans isomerase activity
TINT_RS08340	COG1562	ergosterol biosynthetic process
TINT_RS08345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TINT_RS08355	COG1028	Short-chain dehydrogenase reductase Sdr
TINT_RS08365	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TINT_RS08370	COG0367	asparagine synthase
TINT_RS08380	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TINT_RS08405	COG0563	adenylate kinase activity
TINT_RS08410	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TINT_RS08415	COG2835	tetraacyldisaccharide 4'-kinase activity
TINT_RS08420	COG1663	tetraacyldisaccharide 4'-kinase activity
TINT_RS08430	COG0811	peptide transport
TINT_RS08435	COG1570	exodeoxyribonuclease VII activity
TINT_RS08440	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TINT_RS08470	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TINT_RS08470	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TINT_RS08475	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TINT_RS08480	COG0560	Phosphoserine phosphatase
TINT_RS08495	COG1253	flavin adenine dinucleotide binding
TINT_RS08515	COG0114	fumarate hydratase activity
TINT_RS08520	COG0650	Formate hydrogenlyase subunit 4
TINT_RS08530	COG0651	ATP synthesis coupled electron transport
TINT_RS08535	COG0649	NAD binding
TINT_RS08540	COG3260	NADH ubiquinone oxidoreductase 20
TINT_RS08545	COG0651	ATP synthesis coupled electron transport
TINT_RS08550	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TINT_RS08555	COG1993	acr, cog1993
TINT_RS08565	COG1193	negative regulation of DNA recombination
TINT_RS08575	COG0148	phosphopyruvate hydratase activity
TINT_RS08580	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TINT_RS08590	COG0406	alpha-ribazole phosphatase activity
TINT_RS08595	COG0248	Ppx GppA phosphatase
TINT_RS08600	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TINT_RS08610	COG0745	RESPONSE REGULATOR receiver
TINT_RS08620	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TINT_RS08630	COG0573	inorganic phosphate transmembrane transporter activity
TINT_RS08640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TINT_RS08650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TINT_RS08660	COG1534	Rna-binding protein
TINT_RS08670	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TINT_RS08675	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TINT_RS08685	COG0505	Belongs to the CarA family
TINT_RS08695	COG1960	acyl-CoA dehydrogenase activity
TINT_RS08705	COG2076	Multidrug Resistance protein
TINT_RS08710	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TINT_RS08715	COG1215	transferase activity, transferring glycosyl groups
TINT_RS08725	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TINT_RS08725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TINT_RS08735	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TINT_RS08740	COG0254	rRNA binding
TINT_RS08750	COG0534	Mate efflux family protein
TINT_RS08760	COG0488	(ABC) transporter
TINT_RS08765	COG2890	protein-(glutamine-N5) methyltransferase activity
TINT_RS08770	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TINT_RS08780	COG2171	N-acyltransferase activity
TINT_RS08785	COG0436	Aminotransferase
TINT_RS08805	COG1619	proteins homologs of microcin C7 resistance protein MccF
TINT_RS08820	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TINT_RS08820	COG0519	Catalyzes the synthesis of GMP from XMP
TINT_RS08840	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TINT_RS08845	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TINT_RS08850	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
TINT_RS08855	COG0330	HflC and HflK could
TINT_RS08860	COG0330	HflC and HflK could
TINT_RS08865	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TINT_RS08870	COG1923	regulation of RNA biosynthetic process
TINT_RS08880	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TINT_RS08885	COG2976	Protein conserved in bacteria
TINT_RS08890	COG0124	histidyl-tRNA synthetase
TINT_RS08910	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TINT_RS08915	COG0105	UTP biosynthetic process
TINT_RS08920	COG1187	pseudouridine synthase activity
TINT_RS08925	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TINT_RS08935	COG0347	Belongs to the P(II) protein family
TINT_RS08940	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TINT_RS08940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TINT_RS08950	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TINT_RS08960	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TINT_RS08965	COG0443	Heat shock 70 kDa protein
TINT_RS08970	COG0484	heat shock protein binding
TINT_RS08975	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TINT_RS08980	COG0308	aminopeptidase N
TINT_RS08985	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
TINT_RS09020	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TINT_RS09025	COG0802	atpase or kinase
TINT_RS09030	COG0860	N-Acetylmuramoyl-L-alanine amidase
TINT_RS09035	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TINT_RS09040	COG0726	polysaccharide deacetylase
TINT_RS09055	COG0425	Belongs to the sulfur carrier protein TusA family
TINT_RS09085	COG0842	Transport permease protein
TINT_RS09090	COG0842	Transport permease protein
TINT_RS09095	COG1131	(ABC) transporter
TINT_RS09110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TINT_RS09130	COG0477	Major facilitator Superfamily
TINT_RS09135	COG2326	polyphosphate kinase activity
TINT_RS09165	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TINT_RS09170	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TINT_RS09185	COG3706	GGDEF domain
TINT_RS09215	COG0181	hydroxymethylbilane synthase activity
TINT_RS09220	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TINT_RS09225	COG1752	Esterase of the alpha-beta hydrolase superfamily
TINT_RS09235	COG0671	phosphoesterase, PA-phosphatase related
TINT_RS09250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TINT_RS09270	COG2133	pyrroloquinoline quinone binding
TINT_RS09275	COG0556	nucleotide-excision repair
TINT_RS09290	COG2878	Part of a membrane complex involved in electron transport
TINT_RS09295	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TINT_RS09310	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TINT_RS09315	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TINT_RS09345	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
TINT_RS09355	COG0525	valine-tRNA ligase activity
TINT_RS09360	COG0776	regulation of translation
TINT_RS09370	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TINT_RS09375	COG0287	Prephenate dehydrogenase
TINT_RS09380	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TINT_RS09390	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TINT_RS09405	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TINT_RS09415	COG0557	exoribonuclease II activity
TINT_RS09440	COG2963	transposase activity
TINT_RS09465	COG2135	peptidase activity
TINT_RS09480	COG0587	DNA-directed DNA polymerase activity
TINT_RS09505	COG2442	InterPro IPR007367
TINT_RS09510	COG4634	DNA integration
TINT_RS09565	COG2119	membrane
TINT_RS09605	COG2963	transposase activity
TINT_RS09655	COG0582	viral genome integration into host DNA
TINT_RS09710	COG1733	regulation of RNA biosynthetic process
TINT_RS09730	COG0583	DNA-binding transcription factor activity
TINT_RS09745	COG3039	Transposase
TINT_RS09795	COG2814	Major facilitator Superfamily
TINT_RS09870	COG3451	type IV secretory pathway VirB4
TINT_RS09895	COG3550	peptidyl-serine autophosphorylation
TINT_RS09920	COG2433	Pfam Transposase IS66
TINT_RS09925	COG4372	Transposase
TINT_RS09970	COG1309	transcriptional regulator
TINT_RS09975	COG4962	Type ii secretion system protein e
TINT_RS10005	COG0583	DNA-binding transcription factor activity
TINT_RS10010	COG0477	Major facilitator Superfamily
TINT_RS10020	COG0583	DNA-binding transcription factor activity
TINT_RS10080	COG3177	Filamentation induced by cAMP protein fic
TINT_RS10085	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TINT_RS10095	COG1605	Chorismate mutase
TINT_RS10095	COG0287	Prephenate dehydrogenase
TINT_RS10130	COG0629	single-stranded DNA binding
TINT_RS10150	COG0667	Aldo Keto reductase
TINT_RS10155	COG0583	DNA-binding transcription factor activity
TINT_RS10200	COG1733	regulation of RNA biosynthetic process
TINT_RS10205	COG0477	Major facilitator Superfamily
TINT_RS10215	COG0477	Major facilitator Superfamily
TINT_RS10230	COG0583	DNA-binding transcription factor activity
TINT_RS10245	COG0583	DNA-binding transcription factor activity
TINT_RS10260	COG3842	ATPase activity
TINT_RS10275	COG0431	NADPH-dependent FMN reductase
TINT_RS10310	COG0582	viral genome integration into host DNA
TINT_RS10330	COG0582	viral genome integration into host DNA
TINT_RS10340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TINT_RS10355	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TINT_RS10360	COG1902	pentaerythritol trinitrate reductase activity
TINT_RS10380	COG0446	pyridine nucleotide-disulphide oxidoreductase
TINT_RS10400	COG0730	response to heat
TINT_RS10405	COG0446	pyridine nucleotide-disulphide oxidoreductase
TINT_RS10445	COG3267	Type II secretory pathway component ExeA
TINT_RS10445	COG3409	Peptidoglycan-binding domain 1 protein
TINT_RS10455	COG0489	protein tyrosine kinase activity
TINT_RS10460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TINT_RS10460	COG3321	synthase
TINT_RS10460	COG0318	PFAM AMP-dependent synthetase and ligase
TINT_RS10460	COG0300	oxidoreductase activity
TINT_RS10460	COG1028	Short-chain dehydrogenase reductase Sdr
TINT_RS10475	COG0328	RNA-DNA hybrid ribonuclease activity
TINT_RS10480	COG2226	methyltransferase
TINT_RS10485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TINT_RS10490	COG0741	lytic transglycosylase activity
TINT_RS10490	COG1388	LysM domain
TINT_RS10495	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TINT_RS10520	COG0314	molybdopterin synthase activity
TINT_RS10530	COG0303	'Molybdopterin
TINT_RS10535	COG1763	Mo-molybdopterin cofactor biosynthetic process
TINT_RS10550	COG0436	Aminotransferase
TINT_RS10560	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TINT_RS10565	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TINT_RS10570	COG0305	Participates in initiation and elongation during chromosome replication
TINT_RS10575	COG0359	binds to the 23S rRNA
TINT_RS10580	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TINT_RS10590	COG0360	Binds together with S18 to 16S ribosomal RNA
TINT_RS10600	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TINT_RS10610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TINT_RS10615	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TINT_RS10620	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TINT_RS10625	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TINT_RS10630	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TINT_RS10635	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TINT_RS10650	COG0750	zinc metalloprotease
TINT_RS10655	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TINT_RS10660	COG0575	Belongs to the CDS family
TINT_RS10680	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TINT_RS10685	COG0052	Belongs to the universal ribosomal protein uS2 family
TINT_RS10695	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TINT_RS10700	COG4181	ATPase activity
TINT_RS10710	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
TINT_RS10715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TINT_RS10740	COG1183	phosphatidylcholine synthase activity
TINT_RS10745	COG0688	phosphatidylethanolamine metabolic process
TINT_RS10750	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TINT_RS10755	COG0440	acetolactate synthase activity
TINT_RS10760	COG0028	Belongs to the TPP enzyme family
TINT_RS10795	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TINT_RS10800	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TINT_RS10805	COG0312	modulator of DNA gyrase
TINT_RS10810	COG3028	Belongs to the UPF0307 family
TINT_RS10815	COG0521	Mo-molybdopterin cofactor biosynthetic process
TINT_RS10820	COG0725	ABC transporter, periplasmic molybdate-binding protein
TINT_RS10840	COG0667	Aldo Keto reductase
TINT_RS10845	COG3447	MASE1 domain protein
TINT_RS10845	COG5001	Diguanylate cyclase
TINT_RS10845	COG5002	protein histidine kinase activity
TINT_RS10850	COG1609	Transcriptional regulator
TINT_RS10855	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TINT_RS10855	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
TINT_RS10860	COG1105	Belongs to the carbohydrate kinase PfkB family
TINT_RS10865	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TINT_RS10865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TINT_RS10875	COG0531	amino acid
TINT_RS10890	COG0514	ATP-dependent DNA helicase (RecQ)
TINT_RS10905	COG0670	Belongs to the BI1 family
TINT_RS10910	COG0583	DNA-binding transcription factor activity
TINT_RS10920	COG1703	isobutyryl-CoA mutase activity
TINT_RS10920	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TINT_RS10920	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TINT_RS10930	COG1187	pseudouridine synthase activity
TINT_RS10935	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TINT_RS10945	COG0723	plastoquinol--plastocyanin reductase activity
TINT_RS10950	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TINT_RS10955	COG2857	Cytochrome c1
TINT_RS10960	COG0625	glutathione transferase activity
TINT_RS10965	COG2969	positive regulation of protein catabolic process
TINT_RS11050	COG2226	methyltransferase
TINT_RS11065	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TINT_RS11070	COG0656	L-ascorbic acid biosynthetic process
TINT_RS11080	COG2814	Major facilitator Superfamily
TINT_RS11085	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TINT_RS11090	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TINT_RS11095	COG1280	lysine exporter protein (LysE YggA)
TINT_RS11110	COG0137	argininosuccinate synthase activity
TINT_RS11115	COG3123	guanosine phosphorylase activity
TINT_RS11125	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TINT_RS11140	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TINT_RS11150	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TINT_RS11160	COG0523	cobalamin synthesis protein
TINT_RS11180	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TINT_RS11185	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TINT_RS11190	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TINT_RS11205	COG2186	Transcriptional regulator
TINT_RS11220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TINT_RS11230	COG0700	Nucleoside recognition
TINT_RS11245	COG2223	nitrite transmembrane transporter activity
TINT_RS11265	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TINT_RS11270	COG0494	nUDIX hydrolase
TINT_RS11280	COG1007	ATP synthesis coupled electron transport
TINT_RS11295	COG0713	ATP synthesis coupled electron transport
TINT_RS11310	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TINT_RS11315	COG1034	ATP synthesis coupled electron transport
TINT_RS11330	COG0649	NAD binding
TINT_RS11335	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TINT_RS11340	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TINT_RS11345	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TINT_RS11355	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TINT_RS11360	COG0149	triose-phosphate isomerase activity
TINT_RS11365	COG1063	alcohol dehydrogenase
TINT_RS11370	COG1185	polyribonucleotide nucleotidyltransferase activity
TINT_RS11380	COG0071	Belongs to the small heat shock protein (HSP20) family
TINT_RS11390	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TINT_RS11395	COG2081	HI0933 family
TINT_RS11400	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TINT_RS11410	COG2267	carboxylic ester hydrolase activity
TINT_RS11415	COG0504	CTP synthase activity
TINT_RS11420	COG2877	3-deoxy-8-phosphooctulonate synthase activity
TINT_RS11430	COG0148	phosphopyruvate hydratase activity
TINT_RS11435	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TINT_RS11440	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TINT_RS11450	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
TINT_RS11455	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
TINT_RS11460	COG1139	Iron-sulfur cluster binding protein
TINT_RS11475	COG1686	Belongs to the peptidase S11 family
TINT_RS11505	COG4654	Cytochrome c, class I
TINT_RS11525	COG0604	alcohol dehydrogenase
TINT_RS11530	COG0791	NLP P60 protein
TINT_RS11535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TINT_RS11540	COG0508	dehydrogenase complex catalyzes the overall conversion of
TINT_RS11545	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
TINT_RS11555	COG4566	intracellular signal transduction
TINT_RS11560	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TINT_RS11565	COG0339	signal peptide processing
TINT_RS11575	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TINT_RS11580	COG0167	dihydroorotate dehydrogenase activity
TINT_RS11590	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TINT_RS11605	COG1286	toxin biosynthetic process
TINT_RS11615	COG0285	dihydrofolate synthase activity
TINT_RS11620	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TINT_RS11625	COG0159	tryptophan synthase activity
TINT_RS11630	COG0133	tryptophan synthase activity
TINT_RS11635	COG0135	phosphoribosylanthranilate isomerase activity
TINT_RS11650	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TINT_RS11655	COG0473	3-isopropylmalate dehydrogenase activity
TINT_RS11660	COG0066	3-isopropylmalate dehydratase activity
TINT_RS11670	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TINT_RS11675	COG2226	methyltransferase
TINT_RS11685	COG0372	Belongs to the citrate synthase family
TINT_RS11690	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
TINT_RS11695	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TINT_RS11700	COG1053	succinate dehydrogenase
TINT_RS11705	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
TINT_RS11715	COG2188	Transcriptional regulator
TINT_RS11720	COG0039	L-malate dehydrogenase activity
TINT_RS11745	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TINT_RS11750	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
TINT_RS11755	COG1393	Belongs to the ArsC family
TINT_RS11765	COG3634	alkyl hydroperoxide reductase activity
TINT_RS11775	COG2084	Dehydrogenase
TINT_RS11790	COG0408	coproporphyrinogen oxidase activity
TINT_RS11795	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TINT_RS11800	COG0799	negative regulation of ribosome biogenesis
TINT_RS11810	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
TINT_RS11815	COG0352	thiamine-phosphate diphosphorylase activity
TINT_RS11820	COG0351	phosphomethylpyrimidine kinase
TINT_RS11845	COG0488	(ABC) transporter
TINT_RS11860	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TINT_RS11865	COG0511	ligase activity, forming carbon-carbon bonds
TINT_RS11870	COG0439	Biotin carboxylase
TINT_RS11875	COG2264	protein methyltransferase activity
TINT_RS11885	COG1472	Belongs to the glycosyl hydrolase 3 family
TINT_RS11890	COG0736	holo-[acyl-carrier-protein] synthase activity
TINT_RS11900	COG1381	Involved in DNA repair and RecF pathway recombination
TINT_RS11905	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TINT_RS11910	COG0571	ribonuclease III activity
TINT_RS11925	COG0481	GTPase activity
TINT_RS11930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TINT_RS11955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TINT_RS11960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TINT_RS11965	COG1028	Short-chain dehydrogenase reductase Sdr
TINT_RS11970	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TINT_RS11975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TINT_RS11980	COG0416	fatty acid biosynthetic process
TINT_RS11985	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TINT_RS12000	COG2391	methyltransferase activity
TINT_RS12005	COG0424	maF-like protein
TINT_RS12010	COG0616	signal peptide processing
TINT_RS12010	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TINT_RS12040	COG0564	pseudouridine synthase activity
TINT_RS12045	COG1530	ribonuclease E activity
TINT_RS12050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TINT_RS12055	COG0543	2 iron, 2 sulfur cluster binding
TINT_RS12055	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TINT_RS12080	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TINT_RS12085	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TINT_RS12090	COG1674	ftsk spoiiie
TINT_RS12100	COG0492	ferredoxin-NADP+ reductase activity
TINT_RS12105	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TINT_RS12110	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TINT_RS12120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TINT_RS12120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TINT_RS12125	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TINT_RS12130	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TINT_RS12135	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TINT_RS12135	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TINT_RS12160	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TINT_RS12165	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TINT_RS12170	COG0436	Aminotransferase
TINT_RS12185	COG0824	Thioesterase
TINT_RS12225	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
TINT_RS12230	COG1215	transferase activity, transferring glycosyl groups
TINT_RS12240	COG1132	(ABC) transporter
TINT_RS12260	COG0823	Involved in the tonB-independent uptake of proteins
TINT_RS12265	COG2885	chlorophyll binding
TINT_RS12275	COG2391	methyltransferase activity
TINT_RS12280	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TINT_RS12340	COG1959	2 iron, 2 sulfur cluster binding
TINT_RS12345	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
TINT_RS12355	COG2151	metal-sulfur cluster biosynthetic enzyme
TINT_RS12365	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TINT_RS12370	COG0719	Fe-S assembly protein
TINT_RS12375	COG0396	ATPase activity
TINT_RS12380	COG0719	Fe-S assembly protein
TINT_RS12390	COG3850	Histidine kinase
TINT_RS12395	COG2197	response regulator
TINT_RS12410	COG2223	nitrite transmembrane transporter activity
TINT_RS12415	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
TINT_RS12420	COG1140	nitrate reductase beta subunit
TINT_RS12425	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
TINT_RS12430	COG2181	nitrate reductase activity
TINT_RS12465	COG1484	DNA-dependent DNA replication
TINT_RS12500	COG4575	ribosome binding
TINT_RS12510	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TINT_RS12515	COG0038	chloride channel
TINT_RS12530	COG1469	GTP cyclohydrolase I activity
TINT_RS12545	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TINT_RS12580	COG0473	3-isopropylmalate dehydrogenase activity
TINT_RS12590	COG1331	Highly conserved protein containing a thioredoxin domain
TINT_RS12595	COG0617	tRNA 3'-terminal CCA addition
TINT_RS12605	COG0318	PFAM AMP-dependent synthetase and ligase
TINT_RS12610	COG0210	DNA helicase
TINT_RS12625	COG0741	lytic transglycosylase activity
TINT_RS12630	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TINT_RS12635	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TINT_RS12635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TINT_RS12655	COG2267	carboxylic ester hydrolase activity
TINT_RS12665	COG3150	esterase
TINT_RS12670	COG1028	Short-chain dehydrogenase reductase Sdr
TINT_RS12685	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TINT_RS12690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TINT_RS12695	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TINT_RS12700	COG0351	phosphomethylpyrimidine kinase
TINT_RS12705	COG1773	rubredoxin
TINT_RS12725	COG0840	transmembrane signaling receptor activity
TINT_RS12730	COG2198	Histidine kinase
TINT_RS12730	COG0643	Histidine kinase
TINT_RS12730	COG0784	Response regulator, receiver
TINT_RS12735	COG0415	Belongs to the DNA photolyase family
TINT_RS12740	COG1678	Uncharacterized ACR, COG1678
TINT_RS12745	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TINT_RS12750	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TINT_RS12755	COG0540	Belongs to the ATCase OTCase family
TINT_RS12785	COG1484	DNA-dependent DNA replication
TINT_RS12795	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TINT_RS12800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TINT_RS12805	COG0424	maF-like protein
TINT_RS12810	COG1530	ribonuclease E activity
TINT_RS12830	COG2951	lytic endotransglycosylase activity
TINT_RS12860	COG1088	dTDP-glucose 4,6-dehydratase activity
TINT_RS12865	COG1760	l-serine dehydratase
TINT_RS12875	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TINT_RS12875	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TINT_RS12880	COG0509	glycine decarboxylation via glycine cleavage system
TINT_RS12885	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TINT_RS12915	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TINT_RS12920	COG0795	lipopolysaccharide-transporting ATPase activity
TINT_RS12930	COG0583	DNA-binding transcription factor activity
TINT_RS12935	COG0436	Aminotransferase
TINT_RS12940	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TINT_RS12945	COG1999	signal sequence binding
TINT_RS12980	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TINT_RS12995	COG2226	methyltransferase
TINT_RS13000	COG1040	competence protein
TINT_RS13005	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TINT_RS13015	COG0183	Belongs to the thiolase family
TINT_RS13020	COG1024	Enoyl-CoA hydratase
TINT_RS13020	COG1250	3-hydroxyacyl-CoA dehydrogenase
TINT_RS13025	COG1960	acyl-CoA dehydrogenase activity
TINT_RS13035	COG0243	molybdopterin cofactor binding
TINT_RS13045	COG4232	protein-disulfide reductase activity
TINT_RS13050	COG0842	Transport permease protein
TINT_RS13055	COG1131	(ABC) transporter
TINT_RS13065	COG0202	RNA polymerase activity
TINT_RS13070	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TINT_RS13075	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TINT_RS13080	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TINT_RS13090	COG0201	protein transport
TINT_RS13095	COG0200	Binds to the 23S rRNA
TINT_RS13100	COG1841	ribosomal large subunit assembly
TINT_RS13105	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TINT_RS13110	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TINT_RS13115	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TINT_RS13120	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TINT_RS13125	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TINT_RS13130	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TINT_RS13135	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TINT_RS13140	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TINT_RS13145	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TINT_RS13150	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TINT_RS13155	COG2890	protein-(glutamine-N5) methyltransferase activity
TINT_RS13160	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TINT_RS13165	COG0163	prenyltransferase activity
TINT_RS13170	COG2326	polyphosphate kinase activity
TINT_RS13205	COG1335	isochorismatase
TINT_RS13210	COG0247	lactate metabolic process
TINT_RS13215	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TINT_RS13235	COG2414	aldehyde ferredoxin oxidoreductase
TINT_RS13240	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TINT_RS13255	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TINT_RS13260	COG3039	Transposase
TINT_RS13265	COG2089	acid synthase
TINT_RS13270	COG1083	cytidylyl-transferase
TINT_RS13275	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
TINT_RS13285	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TINT_RS13305	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
TINT_RS13310	COG1074	ATP-dependent DNA helicase activity
TINT_RS13315	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TINT_RS13325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TINT_RS13330	COG1758	RNA polymerase activity
TINT_RS13335	COG0194	GDP metabolic process
TINT_RS13340	COG1561	YicC-like family, N-terminal region
TINT_RS13355	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TINT_RS13360	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TINT_RS13365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TINT_RS13385	COG1116	anion transmembrane transporter activity
TINT_RS13395	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TINT_RS13400	COG1881	PFAM PEBP family protein
TINT_RS13410	COG0642	Histidine kinase
TINT_RS13420	COG0668	transmembrane transport
TINT_RS13430	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
TINT_RS13440	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TINT_RS13455	COG0284	orotidine-5'-phosphate decarboxylase activity
TINT_RS13460	COG0315	cyclic pyranopterin monophosphate synthase activity
TINT_RS13465	COG0312	modulator of DNA gyrase
TINT_RS13480	COG2326	polyphosphate kinase activity
TINT_RS13490	COG1704	LemA family
TINT_RS13495	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
TINT_RS13505	COG2982	Protein involved in outer membrane biogenesis
TINT_RS13510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TINT_RS13515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TINT_RS13540	COG1858	cytochrome C peroxidase
TINT_RS13545	COG3511	phospholipase C
TINT_RS13550	COG0632	four-way junction helicase activity
TINT_RS13555	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TINT_RS13570	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TINT_RS13575	COG0138	bifunctional purine biosynthesis protein purh
TINT_RS13580	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
TINT_RS13585	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TINT_RS13610	COG4770	biotin carboxylase activity
TINT_RS13620	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TINT_RS13625	COG1024	Enoyl-CoA hydratase
TINT_RS13645	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TINT_RS13650	COG0318	PFAM AMP-dependent synthetase and ligase
TINT_RS13660	COG1960	acyl-CoA dehydrogenase activity
TINT_RS13670	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
TINT_RS13680	COG1960	acyl-CoA dehydrogenase activity
TINT_RS13690	COG0789	Transcriptional regulator
TINT_RS13695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TINT_RS13720	COG0297	glycogen (starch) synthase activity
TINT_RS13740	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TINT_RS13750	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
TINT_RS13755	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TINT_RS13765	COG0018	arginyl-trna synthetase
TINT_RS13780	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TINT_RS13785	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TINT_RS13790	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TINT_RS13800	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TINT_RS13805	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TINT_RS13815	COG0356	it plays a direct role in the translocation of protons across the membrane
TINT_RS13855	COG1459	type II secretion system
TINT_RS13925	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TINT_RS13930	COG1715	Restriction endonuclease
TINT_RS13935	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TINT_RS13945	COG1126	abc transporter atp-binding protein
TINT_RS13955	COG0436	Aminotransferase
TINT_RS13965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TINT_RS13980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TINT_RS13985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TINT_RS13990	COG0583	DNA-binding transcription factor activity
TINT_RS13995	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TINT_RS14005	COG4221	oxidoreductase activity
TINT_RS14015	COG0735	belongs to the Fur family
TINT_RS14025	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TINT_RS14030	COG0321	lipoyl(octanoyl) transferase activity
TINT_RS14050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TINT_RS14055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TINT_RS14095	COG0347	Belongs to the P(II) protein family
TINT_RS14100	COG0004	ammonium transporteR
TINT_RS14130	COG0189	ligase activity
TINT_RS14140	COG0450	alkyl hydroperoxide reductase
TINT_RS14155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TINT_RS14180	COG1660	Displays ATPase and GTPase activities
TINT_RS14185	COG0497	DNA recombination
TINT_RS14195	COG1420	regulation of RNA biosynthetic process
TINT_RS14210	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
TINT_RS14215	COG1765	OsmC-like protein
TINT_RS14225	COG1238	metal cluster binding
TINT_RS14230	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TINT_RS14255	COG1028	Short-chain dehydrogenase reductase Sdr
TINT_RS14270	COG2814	Major facilitator Superfamily
TINT_RS14275	COG0583	DNA-binding transcription factor activity
TINT_RS14290	COG2084	Dehydrogenase
TINT_RS14295	COG3622	Belongs to the hyi family
TINT_RS14300	COG3960	tartronate-semialdehyde synthase activity
TINT_RS14310	COG1942	4-Oxalocrotonate Tautomerase
TINT_RS14315	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TINT_RS14320	COG1566	PFAM secretion protein HlyD family protein
TINT_RS14330	COG1136	(ABC) transporter
TINT_RS14340	COG0012	GTP binding
TINT_RS14350	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TINT_RS14355	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TINT_RS14360	COG0255	Belongs to the universal ribosomal protein uL29 family
TINT_RS14365	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TINT_RS14370	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TINT_RS14375	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TINT_RS14380	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TINT_RS14385	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TINT_RS14390	COG0089	rRNA binding
TINT_RS14395	COG0088	Forms part of the polypeptide exit tunnel
TINT_RS14400	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TINT_RS14405	COG0051	transcription antitermination factor activity, RNA binding
TINT_RS14410	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TINT_RS14415	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TINT_RS14420	COG0049	tRNA binding
TINT_RS14425	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TINT_RS14455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TINT_RS14460	COG2197	response regulator
TINT_RS14465	COG1702	phosphate starvation-inducible protein PhoH
TINT_RS14470	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TINT_RS14475	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TINT_RS14485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TINT_RS14490	COG2814	Major facilitator Superfamily
TINT_RS14495	COG3258	Cytochrome c
TINT_RS14500	COG2863	cytochrome
TINT_RS14510	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TINT_RS14525	COG2863	cytochrome
TINT_RS14530	COG0446	pyridine nucleotide-disulphide oxidoreductase
TINT_RS14540	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TINT_RS14540	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TINT_RS14550	COG5000	phosphorelay sensor kinase activity
TINT_RS14555	COG2204	response regulator
TINT_RS14595	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TINT_RS14655	COG5377	YqaJ viral recombinase family
TINT_RS14675	COG4983	Phage plasmid primase, P4 family domain protein
TINT_RS14715	COG0582	viral genome integration into host DNA
TINT_RS14730	COG3161	chorismate lyase activity
TINT_RS14740	COG0583	DNA-binding transcription factor activity
TINT_RS14745	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TINT_RS14755	COG0725	ABC transporter, periplasmic molybdate-binding protein
TINT_RS14760	COG4149	molybdate abc transporter
TINT_RS14765	COG3842	ATPase activity
TINT_RS14805	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TINT_RS14825	COG0437	4 iron, 4 sulfur cluster binding
TINT_RS14830	COG3383	formate dehydrogenase (NAD+) activity
TINT_RS14830	COG0243	molybdopterin cofactor binding
TINT_RS14845	COG0247	lactate metabolic process
TINT_RS14845	COG2181	nitrate reductase activity
TINT_RS14865	COG1970	mechanosensitive ion channel activity
TINT_RS14890	COG2911	Protein conserved in bacteria
TINT_RS14895	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TINT_RS14925	COG2223	nitrite transmembrane transporter activity
TINT_RS14935	COG0667	Aldo Keto reductase
TINT_RS14945	COG1484	DNA-dependent DNA replication
TINT_RS15005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TINT_RS15020	COG1012	belongs to the aldehyde dehydrogenase family
TINT_RS15020	COG2030	dehydratase
TINT_RS15025	COG0183	Belongs to the thiolase family
TINT_RS15030	COG1309	transcriptional regulator
TINT_RS15035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TINT_RS15040	COG2151	metal-sulfur cluster biosynthetic enzyme
TINT_RS15045	COG3396	Phenylacetate-CoA oxygenase
TINT_RS15050	COG3460	Phenylacetate-CoA oxygenase
TINT_RS15055	COG3396	Phenylacetate-CoA oxygenase
TINT_RS15065	COG2050	protein possibly involved in aromatic compounds catabolism
TINT_RS15070	COG1250	3-hydroxyacyl-CoA dehydrogenase
TINT_RS15075	COG1024	Enoyl-CoA hydratase
TINT_RS15085	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
TINT_RS15120	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
TINT_RS15135	COG1280	lysine exporter protein (LysE YggA)
TINT_RS15155	COG3668	Plasmid stabilization system
TINT_RS15160	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
TINT_RS15165	COG0367	asparagine synthase
TINT_RS15210	COG0431	NADPH-dependent FMN reductase
TINT_RS15225	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
TINT_RS15280	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
TINT_RS15330	COG4654	Cytochrome c, class I
TINT_RS15335	COG0243	molybdopterin cofactor binding
TINT_RS15340	COG0723	plastoquinol--plastocyanin reductase activity
TINT_RS15360	COG2132	Multicopper oxidase
TINT_RS15390	COG3039	Transposase
TINT_RS15395	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
TINT_RS15410	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
TINT_RS15420	COG0298	carbon dioxide binding
TINT_RS15430	COG1773	rubredoxin
TINT_RS15445	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
TINT_RS15450	COG0375	protein maturation
TINT_RS15460	COG2204	response regulator
TINT_RS15485	COG0298	carbon dioxide binding
TINT_RS15490	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TINT_RS15530	COG0582	viral genome integration into host DNA
TINT_RS15550	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TINT_RS15555	COG0085	RNA polymerase activity
TINT_RS15560	COG0222	ribosome binding
TINT_RS15565	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TINT_RS15570	COG0081	regulation of translation
TINT_RS15575	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TINT_RS15595	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TINT_RS15615	COG0134	indole-3-glycerol-phosphate synthase activity
TINT_RS15620	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TINT_RS15650	COG0546	phosphoglycolate phosphatase activity
TINT_RS15655	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TINT_RS15660	COG2967	ApaG domain
TINT_RS15670	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
TINT_RS15680	COG2354	Protein conserved in bacteria
TINT_RS15685	COG0730	response to heat
TINT_RS15700	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TINT_RS15705	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TINT_RS15715	COG2814	Major facilitator Superfamily
TINT_RS15730	COG2321	neutral zinc metallopeptidase
TINT_RS15760	COG1305	Transglutaminase-like
TINT_RS15785	COG2847	Copper chaperone PCu(A)C
TINT_RS15790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TINT_RS15800	COG2010	Cytochrome c
TINT_RS15815	COG2015	COG2015, Alkyl sulfatase and related hydrolases
TINT_RS15820	COG1914	H( )-stimulated, divalent metal cation uptake system
TINT_RS15835	COG3158	transport of potassium into the cell
TINT_RS15840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TINT_RS15845	COG2095	MarC family integral membrane protein
TINT_RS15850	COG0730	response to heat
TINT_RS15870	COG0357	Ribosomal RNA small subunit methyltransferase G
TINT_RS15875	COG1192	Involved in chromosome partitioning
TINT_RS15885	COG1475	DNA binding
TINT_RS15940	COG1620	l-lactate permease
TINT_RS15950	COG2271	Major facilitator Superfamily
TINT_RS15955	COG1484	DNA-dependent DNA replication
TINT_RS15970	COG0640	Transcriptional regulator
TINT_RS15990	COG0559	Belongs to the binding-protein-dependent transport system permease family
TINT_RS16005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TINT_RS16010	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TINT_RS16015	COG0706	membrane insertase activity
TINT_RS16025	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TINT_RS16200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TINT_RS16205	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TINT_RS16490	COG3842	ATPase activity