locus-tag	class	description
THII_RS00005	COG0542	response to heat
THII_RS00095	COG2234	aminopeptidase activity
THII_RS00100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THII_RS00105	COG4589	Belongs to the CDS family
THII_RS00140	COG0243	molybdopterin cofactor binding
THII_RS00150	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
THII_RS00160	COG0287	Prephenate dehydrogenase
THII_RS00165	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
THII_RS00175	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
THII_RS00185	COG0776	regulation of translation
THII_RS00190	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
THII_RS00195	COG0284	orotidine-5'-phosphate decarboxylase activity
THII_RS00200	COG1011	Hydrolase
THII_RS00210	COG0653	protein targeting
THII_RS00240	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
THII_RS00245	COG0084	hydrolase, TatD family'
THII_RS00250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THII_RS00255	COG5002	protein histidine kinase activity
THII_RS00255	COG5001	Diguanylate cyclase
THII_RS00315	COG1752	Esterase of the alpha-beta hydrolase superfamily
THII_RS00330	COG3118	belongs to the thioredoxin family
THII_RS00340	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
THII_RS00345	COG0418	dihydroorotase activity
THII_RS00355	COG0784	Response regulator, receiver
THII_RS00355	COG2205	protein histidine kinase activity
THII_RS00360	COG2831	hemolysin activation secretion protein
THII_RS00380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THII_RS00405	COG3335	DDE superfamily endonuclease
THII_RS00460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THII_RS00465	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
THII_RS00465	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
THII_RS00475	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
THII_RS00485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THII_RS00515	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
THII_RS00540	COG0859	PFAM glycosyl transferase family 9
THII_RS00560	COG1999	signal sequence binding
THII_RS00600	COG0067	glutamate synthase
THII_RS00600	COG0069	glutamate synthase activity
THII_RS00600	COG0070	glutamate synthase
THII_RS00605	COG2226	methyltransferase
THII_RS00620	COG2311	Membrane
THII_RS00635	COG1872	DUF167
THII_RS00650	COG0714	Associated with various cellular activities
THII_RS00695	COG1136	(ABC) transporter
THII_RS00695	COG0577	efflux transmembrane transporter activity
THII_RS00715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THII_RS00715	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THII_RS00720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THII_RS00740	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THII_RS00745	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
THII_RS00750	COG0740	serine-type endopeptidase activity
THII_RS00755	COG0544	peptidyl-prolyl cis-trans isomerase activity
THII_RS00770	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
THII_RS00775	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
THII_RS00790	COG0072	phenylalanine-tRNA ligase activity
THII_RS00795	COG0776	regulation of translation
THII_RS00805	COG0316	Belongs to the HesB IscA family
THII_RS00900	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
THII_RS00905	COG0860	N-Acetylmuramoyl-L-alanine amidase
THII_RS00910	COG0330	HflC and HflK could
THII_RS00925	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
THII_RS00940	COG0837	glucose binding
THII_RS00950	COG4636	protein conserved in cyanobacteria
THII_RS00970	COG0784	Response regulator, receiver
THII_RS00970	COG2205	protein histidine kinase activity
THII_RS00980	COG1254	Belongs to the acylphosphatase family
THII_RS01000	COG2080	2 iron, 2 sulfur cluster binding
THII_RS01005	COG0527	aspartate kinase activity
THII_RS01010	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
THII_RS01040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THII_RS01065	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
THII_RS01090	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
THII_RS01100	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THII_RS01100	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THII_RS01105	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
THII_RS01135	COG4206	TonB-dependent receptor
THII_RS01180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THII_RS01225	COG1597	lipid kinase activity
THII_RS01230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
THII_RS01245	COG0477	Major facilitator Superfamily
THII_RS01255	COG1758	RNA polymerase activity
THII_RS01260	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THII_RS01265	COG3079	Belongs to the UPF0149 family
THII_RS01270	COG0006	proline dipeptidase activity
THII_RS01300	COG0174	glutamine synthetase
THII_RS01305	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
THII_RS01310	COG1361	Conserved repeat domain
THII_RS01315	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
THII_RS01320	COG0424	maF-like protein
THII_RS01340	COG0366	Alpha amylase catalytic
THII_RS01340	COG1874	Beta-galactosidase
THII_RS01345	COG0784	Response regulator, receiver
THII_RS01345	COG2205	protein histidine kinase activity
THII_RS01345	COG2198	Histidine kinase
THII_RS01360	COG4654	Cytochrome c, class I
THII_RS01365	COG0243	molybdopterin cofactor binding
THII_RS01405	COG4636	protein conserved in cyanobacteria
THII_RS01440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THII_RS01445	COG0203	ribosomal protein L17
THII_RS01450	COG0202	RNA polymerase activity
THII_RS01455	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
THII_RS01465	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
THII_RS01470	COG0201	protein transport
THII_RS01475	COG0200	Binds to the 23S rRNA
THII_RS01480	COG1841	ribosomal large subunit assembly
THII_RS01485	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
THII_RS01490	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
THII_RS01495	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
THII_RS01500	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
THII_RS01505	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
THII_RS01510	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
THII_RS01515	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
THII_RS01520	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
THII_RS01530	COG0255	Belongs to the universal ribosomal protein uL29 family
THII_RS01535	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
THII_RS01540	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
THII_RS01545	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
THII_RS01550	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
THII_RS01555	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
THII_RS01560	COG0089	rRNA binding
THII_RS01565	COG0088	Forms part of the polypeptide exit tunnel
THII_RS01570	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
THII_RS01575	COG0051	transcription antitermination factor activity, RNA binding
THII_RS01580	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THII_RS01585	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THII_RS01595	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
THII_RS01640	COG3909	cytochrome
THII_RS01670	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
THII_RS01690	COG2010	Cytochrome c
THII_RS01700	COG0714	Associated with various cellular activities
THII_RS01760	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
THII_RS01765	COG0071	Belongs to the small heat shock protein (HSP20) family
THII_RS01770	COG5002	protein histidine kinase activity
THII_RS01775	COG2957	Belongs to the agmatine deiminase family
THII_RS01795	COG2268	Band 7 protein
THII_RS01800	COG1585	Membrane protein implicated in regulation of membrane protease activity
THII_RS01815	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
THII_RS01820	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
THII_RS01845	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
THII_RS01850	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THII_RS01855	COG0505	Belongs to the CarA family
THII_RS01915	COG0205	6-phosphofructokinase activity
THII_RS01935	COG1121	(ABC) transporter
THII_RS01940	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THII_RS01960	COG0523	cobalamin synthesis protein
THII_RS01980	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
THII_RS02055	COG1643	Atp-dependent helicase
THII_RS02070	COG0037	tRNA processing
THII_RS02075	COG0326	Molecular chaperone. Has ATPase activity
THII_RS02090	COG2949	membrane
THII_RS02105	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
THII_RS02110	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
THII_RS02115	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
THII_RS02120	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
THII_RS02125	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THII_RS02135	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THII_RS02145	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
THII_RS02170	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
THII_RS02175	COG1053	succinate dehydrogenase
THII_RS02185	COG2009	succinate dehydrogenase
THII_RS02200	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
THII_RS02235	COG3437	response regulator, receiver
THII_RS02235	COG0784	Response regulator, receiver
THII_RS02245	COG1216	Glycosyl transferase, family 2
THII_RS02320	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
THII_RS02330	COG0281	malic enzyme
THII_RS02330	COG0280	phosphate acetyltransferase
THII_RS02335	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
THII_RS02365	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
THII_RS02380	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THII_RS02385	COG0242	peptide deformylase activity
THII_RS02390	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THII_RS02400	COG0827	DNA restriction-modification system
THII_RS02405	COG0827	DNA restriction-modification system
THII_RS02415	COG1690	Belongs to the RtcB family
THII_RS02430	COG1136	(ABC) transporter
THII_RS02440	COG1136	(ABC) transporter
THII_RS02445	COG1136	(ABC) transporter
THII_RS02445	COG0577	efflux transmembrane transporter activity
THII_RS02465	COG2204	response regulator
THII_RS02505	COG0784	Response regulator, receiver
THII_RS02505	COG5002	protein histidine kinase activity
THII_RS02525	COG1477	protein flavinylation
THII_RS02570	COG0217	transcriptional regulatory protein
THII_RS02575	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
THII_RS02585	COG2267	carboxylic ester hydrolase activity
THII_RS02595	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THII_RS02600	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THII_RS02610	COG0649	NAD binding
THII_RS02670	COG2224	Isocitrate lyase
THII_RS02675	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
THII_RS02695	COG0529	Catalyzes the synthesis of activated sulfate
THII_RS02705	COG2202	Pas domain
THII_RS02705	COG2205	protein histidine kinase activity
THII_RS02715	COG3106	COG3106 Predicted ATPase
THII_RS02745	COG2201	protein-glutamate methylesterase activity
THII_RS02750	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
THII_RS02760	COG0840	transmembrane signaling receptor activity
THII_RS02770	COG0643	Histidine kinase
THII_RS02770	COG2198	Histidine kinase
THII_RS02775	COG0745	RESPONSE REGULATOR receiver
THII_RS02790	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THII_RS02795	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
THII_RS02805	COG0322	excinuclease ABC activity
THII_RS02830	COG1598	PFAM Uncharacterised protein family UPF0150
THII_RS02845	COG4115	mRNA cleavage
THII_RS02850	COG2161	toxin-antitoxin pair type II binding
THII_RS02875	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THII_RS02900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
THII_RS02910	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
THII_RS02940	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THII_RS02940	COG1024	Enoyl-CoA hydratase
THII_RS02945	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
THII_RS02950	COG0285	dihydrofolate synthase activity
THII_RS02955	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
THII_RS02960	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THII_RS02960	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THII_RS03000	COG2076	Multidrug Resistance protein
THII_RS03005	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
THII_RS03030	COG2221	Nitrite and sulphite reductase 4Fe-4S
THII_RS03035	COG2221	Nitrite and sulphite reductase 4Fe-4S
THII_RS03040	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
THII_RS03045	COG2923	Belongs to the DsrF TusC family
THII_RS03055	COG2920	part of a sulfur-relay system
THII_RS03070	COG0493	'glutamate synthase
THII_RS03090	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THII_RS03150	COG1074	ATP-dependent DNA helicase activity
THII_RS03165	COG0438	transferase activity, transferring glycosyl groups
THII_RS03180	COG1196	nuclear chromosome segregation
THII_RS03200	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
THII_RS03215	COG0540	Belongs to the ATCase OTCase family
THII_RS03220	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
THII_RS03225	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
THII_RS03230	COG1678	Uncharacterized ACR, COG1678
THII_RS03250	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
THII_RS03250	COG4797	methyltransferase
THII_RS03260	COG0583	DNA-binding transcription factor activity
THII_RS03280	COG4133	protoheme IX ABC transporter activity
THII_RS03285	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
THII_RS03305	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
THII_RS03315	COG0546	phosphoglycolate phosphatase activity
THII_RS03320	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THII_RS03335	COG0318	PFAM AMP-dependent synthetase and ligase
THII_RS03370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THII_RS03375	COG0601	transmembrane transport
THII_RS03400	COG2972	Histidine kinase
THII_RS03400	COG0745	RESPONSE REGULATOR receiver
THII_RS03405	COG1305	Transglutaminase-like
THII_RS03435	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THII_RS03440	COG0163	prenyltransferase activity
THII_RS03490	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
THII_RS03490	COG2105	PFAM AIG2 family protein
THII_RS03495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
THII_RS03500	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
THII_RS03505	COG0505	Belongs to the CarA family
THII_RS03520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THII_RS03525	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
THII_RS03540	COG0438	transferase activity, transferring glycosyl groups
THII_RS03540	COG1216	Glycosyl transferase, family 2
THII_RS03590	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
THII_RS03595	COG0706	membrane insertase activity
THII_RS03635	COG0463	Glycosyl transferase, family 2
THII_RS03640	COG3551	Protein conserved in bacteria
THII_RS03645	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THII_RS03655	COG0463	Glycosyl transferase, family 2
THII_RS03660	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THII_RS03665	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THII_RS03680	COG0673	inositol 2-dehydrogenase activity
THII_RS03685	COG3240	lipase activity
THII_RS03700	COG0742	ribosomal rna small subunit methyltransferase
THII_RS03705	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
THII_RS03715	COG5002	protein histidine kinase activity
THII_RS03715	COG0784	Response regulator, receiver
THII_RS03735	COG0165	Argininosuccinate lyase
THII_RS03745	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
THII_RS03760	COG3621	Patatin-like phospholipase
THII_RS03775	COG0463	Glycosyl transferase, family 2
THII_RS03785	COG1132	(ABC) transporter
THII_RS03795	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
THII_RS03800	COG2885	chlorophyll binding
THII_RS03810	COG0795	lipopolysaccharide-transporting ATPase activity
THII_RS03825	COG3954	Phosphoribulokinase
THII_RS03865	COG0493	'glutamate synthase
THII_RS03865	COG0543	2 iron, 2 sulfur cluster binding
THII_RS03875	COG0552	protein localization to endoplasmic reticulum
THII_RS03880	COG2884	Cell division ATP-binding protein ftsE
THII_RS03885	COG2177	Part of the ABC transporter FtsEX involved in
THII_RS03895	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
THII_RS03900	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
THII_RS03935	COG3620	sequence-specific DNA binding
THII_RS03950	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THII_RS03950	COG0731	radical SAM domain protein
THII_RS03965	COG0489	protein tyrosine kinase activity
THII_RS03965	COG3206	protein involved in exopolysaccharide biosynthesis
THII_RS03990	COG0745	RESPONSE REGULATOR receiver
THII_RS03995	COG4191	Histidine kinase
THII_RS04005	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
THII_RS04010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
THII_RS04025	COG1136	(ABC) transporter
THII_RS04050	COG0494	nUDIX hydrolase
THII_RS04060	COG3220	belongs to the UPF0276 family
THII_RS04080	COG2911	Protein conserved in bacteria
THII_RS04095	COG3621	Patatin-like phospholipase
THII_RS04120	COG0463	Glycosyl transferase, family 2
THII_RS04145	COG1301	dicarboxylic acid transport
THII_RS04150	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
THII_RS04160	COG1028	Short-chain dehydrogenase reductase Sdr
THII_RS04170	COG0183	Belongs to the thiolase family
THII_RS04180	COG3260	NADH ubiquinone oxidoreductase 20
THII_RS04185	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THII_RS04200	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
THII_RS04205	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
THII_RS04210	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
THII_RS04225	COG2969	positive regulation of protein catabolic process
THII_RS04230	COG2857	Cytochrome c1
THII_RS04235	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
THII_RS04240	COG0723	plastoquinol--plastocyanin reductase activity
THII_RS04245	COG1450	Type ii and iii secretion system protein
THII_RS04255	COG2165	general secretion pathway protein
THII_RS04260	COG4969	Belongs to the N-Me-Phe pilin family
THII_RS04265	COG2165	general secretion pathway protein
THII_RS04285	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
THII_RS04290	COG0640	Transcriptional regulator
THII_RS04295	COG0798	PFAM Bile acid sodium symporter
THII_RS04300	COG0701	Predicted permease
THII_RS04310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THII_RS04330	COG2319	Wd-40 repeat
THII_RS04330	COG4249	Peptidase C14 caspase catalytic subunit p20
THII_RS04345	COG2890	protein-(glutamine-N5) methyltransferase activity
THII_RS04360	COG0745	RESPONSE REGULATOR receiver
THII_RS04375	COG1619	proteins homologs of microcin C7 resistance protein MccF
THII_RS04400	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
THII_RS04425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THII_RS04485	COG2027	D-alanyl-D-alanine carboxypeptidase
THII_RS04500	COG0464	growth
THII_RS04530	COG0651	ATP synthesis coupled electron transport
THII_RS04535	COG0649	NAD binding
THII_RS04560	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THII_RS04590	COG3119	arylsulfatase activity
THII_RS04595	COG2003	Belongs to the UPF0758 family
THII_RS04600	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THII_RS04610	COG0602	queuosine metabolic process
THII_RS04625	COG0494	nUDIX hydrolase
THII_RS04635	COG4797	methyltransferase
THII_RS04635	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
THII_RS04660	COG2197	response regulator
THII_RS04675	COG3103	Sh3 type 3 domain protein
THII_RS04675	COG0791	NLP P60 protein
THII_RS04675	COG1388	LysM domain
THII_RS04680	COG3228	Belongs to the MtfA family
THII_RS04685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THII_RS04695	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
THII_RS04700	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THII_RS04745	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
THII_RS04750	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THII_RS04795	COG0714	Associated with various cellular activities
THII_RS04800	COG0859	PFAM glycosyl transferase family 9
THII_RS04835	COG0343	queuine tRNA-ribosyltransferase activity
THII_RS04840	COG2161	toxin-antitoxin pair type II binding
THII_RS04845	COG1648	precorrin-2 dehydrogenase activity
THII_RS04845	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
THII_RS04850	COG0425	Belongs to the sulfur carrier protein TusA family
THII_RS04855	COG2210	Belongs to the sulfur carrier protein TusA family
THII_RS04860	COG0277	FAD linked oxidase domain protein
THII_RS04935	COG1662	PFAM IS1 transposase
THII_RS05025	COG0784	Response regulator, receiver
THII_RS05025	COG2205	protein histidine kinase activity
THII_RS05025	COG5002	protein histidine kinase activity
THII_RS05060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THII_RS05065	COG0354	folic acid binding
THII_RS05070	COG0739	heme binding
THII_RS05080	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
THII_RS05090	COG0473	3-isopropylmalate dehydrogenase activity
THII_RS05095	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
THII_RS05105	COG0101	tRNA pseudouridine synthase activity
THII_RS05120	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
THII_RS05125	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
THII_RS05160	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
THII_RS05180	COG2226	methyltransferase
THII_RS05200	COG0489	protein tyrosine kinase activity
THII_RS05205	COG2046	Belongs to the sulfate adenylyltransferase family
THII_RS05325	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
THII_RS05330	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
THII_RS05365	COG0463	Glycosyl transferase, family 2
THII_RS05415	COG1943	Transposase
THII_RS05450	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THII_RS05460	COG0463	Glycosyl transferase, family 2
THII_RS05490	COG0730	response to heat
THII_RS05530	COG4245	von Willebrand factor, type A
THII_RS05565	COG1210	Utp--glucose-1-phosphate uridylyltransferase
THII_RS05570	COG2020	methyltransferase activity
THII_RS05605	COG0463	Glycosyl transferase, family 2
THII_RS05610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THII_RS05655	COG2239	Acts as a magnesium transporter
THII_RS05665	COG3025	triphosphatase activity
THII_RS05670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THII_RS05690	COG0606	chelatase, subunit chli
THII_RS05700	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
THII_RS05720	COG0811	peptide transport
THII_RS05755	COG2171	N-acyltransferase activity
THII_RS05765	COG0779	Required for maturation of 30S ribosomal subunits
THII_RS05770	COG2251	uridine kinase activity
THII_RS05770	COG0195	Participates in both transcription termination and antitermination
THII_RS05780	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
THII_RS05785	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
THII_RS05790	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
THII_RS05795	COG1185	polyribonucleotide nucleotidyltransferase activity
THII_RS05845	COG0784	Response regulator, receiver
THII_RS05845	COG5002	protein histidine kinase activity
THII_RS05845	COG2205	protein histidine kinase activity
THII_RS05865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THII_RS05870	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
THII_RS05875	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THII_RS05885	COG0275	rRNA processing
THII_RS05925	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THII_RS05930	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THII_RS05935	COG1862	Preprotein translocase
THII_RS05945	COG4636	protein conserved in cyanobacteria
THII_RS05950	COG0187	DNA topoisomerase II activity
THII_RS05970	COG0514	ATP-dependent DNA helicase (RecQ)
THII_RS05975	COG2311	Membrane
THII_RS05980	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
THII_RS06005	COG0463	Glycosyl transferase, family 2
THII_RS06015	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
THII_RS06035	COG3243	poly(R)-hydroxyalkanoic acid synthase
THII_RS06045	COG1472	Belongs to the glycosyl hydrolase 3 family
THII_RS06065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THII_RS06095	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
THII_RS06115	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
THII_RS06120	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
THII_RS06140	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
THII_RS06145	COG1137	ATPase activity
THII_RS06150	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
THII_RS06160	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
THII_RS06215	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
THII_RS06225	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THII_RS06225	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THII_RS06250	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
THII_RS06255	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
THII_RS06260	COG1196	nuclear chromosome segregation
THII_RS06260	COG0739	heme binding
THII_RS06260	COG0741	lytic transglycosylase activity
THII_RS06265	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
THII_RS06290	COG2198	Histidine kinase
THII_RS06290	COG0784	Response regulator, receiver
THII_RS06290	COG0643	Histidine kinase
THII_RS06300	COG0840	transmembrane signaling receptor activity
THII_RS06370	COG3243	poly(R)-hydroxyalkanoic acid synthase
THII_RS06375	COG0557	exoribonuclease II activity
THII_RS06385	COG0521	Mo-molybdopterin cofactor biosynthetic process
THII_RS06400	COG0795	lipopolysaccharide-transporting ATPase activity
THII_RS06405	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
THII_RS06430	COG0033	Phosphoglucomutase
THII_RS06445	COG1136	(ABC) transporter
THII_RS06460	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
THII_RS06470	COG3107	peptidoglycan biosynthetic process
THII_RS06475	COG0792	nuclease activity
THII_RS06480	COG1131	(ABC) transporter
THII_RS06500	COG0501	Belongs to the peptidase M48B family
THII_RS06515	COG2814	Major facilitator Superfamily
THII_RS06525	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
THII_RS06530	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
THII_RS06535	COG0494	nUDIX hydrolase
THII_RS06540	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
THII_RS06545	COG0107	imidazoleglycerol-phosphate synthase activity
THII_RS06555	COG0140	phosphoribosyl-ATP diphosphatase activity
THII_RS06570	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THII_RS06575	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THII_RS06580	COG0805	protein transport
THII_RS06605	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
THII_RS06610	COG1088	dTDP-glucose 4,6-dehydratase activity
THII_RS06705	COG0142	geranyltranstransferase activity
THII_RS06740	COG0753	catalase activity
THII_RS06750	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
THII_RS06755	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
THII_RS06760	COG0653	protein targeting
THII_RS06765	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
THII_RS06770	COG0352	thiamine-phosphate diphosphorylase activity
THII_RS06780	COG1215	transferase activity, transferring glycosyl groups
THII_RS06810	COG4166	transmembrane transport
THII_RS06820	COG4174	ABC transporter (Permease)
THII_RS06825	COG4239	(ABC) transporter, permease
THII_RS06845	COG0105	UTP biosynthetic process
THII_RS06850	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THII_RS06860	COG1426	Protein conserved in bacteria
THII_RS06865	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
THII_RS06880	COG0315	cyclic pyranopterin monophosphate synthase activity
THII_RS06890	COG0513	Belongs to the DEAD box helicase family
THII_RS06915	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
THII_RS06920	COG2137	regulation of response to DNA damage stimulus
THII_RS06925	COG1372	Participates in initiation and elongation during chromosome replication
THII_RS06925	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
THII_RS06950	COG2217	Heavy metal translocating P-type atpase
THII_RS06960	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
THII_RS06980	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
THII_RS06985	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THII_RS06990	COG2835	tetraacyldisaccharide 4'-kinase activity
THII_RS06995	COG1663	tetraacyldisaccharide 4'-kinase activity
THII_RS07000	COG0848	biopolymer transport protein
THII_RS07005	COG0811	peptide transport
THII_RS07010	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
THII_RS07035	COG4797	methyltransferase
THII_RS07035	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
THII_RS07050	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
THII_RS07065	COG0166	Belongs to the GPI family
THII_RS07070	COG1640	4-alpha-glucanotransferase
THII_RS07080	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
THII_RS07145	COG2062	phosphohistidine phosphatase, SixA
THII_RS07150	COG0708	Exodeoxyribonuclease III
THII_RS07155	COG0612	Peptidase, M16
THII_RS07160	COG0612	Peptidase, M16
THII_RS07165	COG1040	competence protein
THII_RS07175	COG3264	Mechanosensitive ion channel
THII_RS07175	COG1511	domain protein
THII_RS07185	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
THII_RS07190	COG1469	GTP cyclohydrolase I activity
THII_RS07195	COG1496	oxidoreductase activity
THII_RS07220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THII_RS07225	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
THII_RS07235	COG2862	Uncharacterized protein family, UPF0114
THII_RS07310	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THII_RS07315	COG0459	protein refolding
THII_RS07320	COG1575	Belongs to the MenA family. Type 1 subfamily
THII_RS07330	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
THII_RS07340	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THII_RS07365	COG1858	cytochrome C peroxidase
THII_RS07380	COG5265	(ABC) transporter
THII_RS07420	COG2308	Evidence 4 Homologs of previously reported genes of
THII_RS07430	COG4783	chaperone-mediated protein folding
THII_RS07440	COG2205	protein histidine kinase activity
THII_RS07440	COG5002	protein histidine kinase activity
THII_RS07440	COG0784	Response regulator, receiver
THII_RS07470	COG1943	Transposase
THII_RS07475	COG3259	Nickel-dependent hydrogenase
THII_RS07480	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
THII_RS07485	COG3383	formate dehydrogenase (NAD+) activity
THII_RS07490	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
THII_RS07495	COG0823	Involved in the tonB-independent uptake of proteins
THII_RS07510	COG0848	biopolymer transport protein
THII_RS07515	COG0811	peptide transport
THII_RS07520	COG0824	Thioesterase
THII_RS07525	COG2255	four-way junction helicase activity
THII_RS07555	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THII_RS07575	COG5001	Diguanylate cyclase
THII_RS07575	COG4251	negative regulation of phosphorylation
THII_RS07575	COG3706	GGDEF domain
THII_RS07575	COG2203	Gaf domain
THII_RS07580	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
THII_RS07585	COG0564	pseudouridine synthase activity
THII_RS07600	COG0339	signal peptide processing
THII_RS07605	COG0058	SHG alpha-glucan phosphorylase activity
THII_RS07610	COG0651	ATP synthesis coupled electron transport
THII_RS07615	COG0650	Formate hydrogenlyase subunit 4
THII_RS07640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THII_RS07680	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
THII_RS07695	COG0227	Belongs to the bacterial ribosomal protein bL28 family
THII_RS07705	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
THII_RS07710	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
THII_RS07715	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
THII_RS07715	COG4797	methyltransferase
THII_RS07720	COG0745	RESPONSE REGULATOR receiver
THII_RS07725	COG2205	protein histidine kinase activity
THII_RS07745	COG0617	tRNA 3'-terminal CCA addition
THII_RS07750	COG1090	epimerase
THII_RS07795	COG4191	Histidine kinase
THII_RS07795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THII_RS07825	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
THII_RS07840	COG2226	methyltransferase
THII_RS07860	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
THII_RS07875	COG2264	protein methyltransferase activity
THII_RS07935	COG3278	Belongs to the heme-copper respiratory oxidase family
THII_RS07950	COG2010	Cytochrome c
THII_RS07955	COG1966	Carbon starvation protein
THII_RS07980	COG0745	RESPONSE REGULATOR receiver
THII_RS07985	COG2205	protein histidine kinase activity
THII_RS08015	COG0784	Response regulator, receiver
THII_RS08015	COG5002	protein histidine kinase activity
THII_RS08025	COG0138	bifunctional purine biosynthesis protein purh
THII_RS08030	COG1218	3'(2'),5'-bisphosphate nucleotidase
THII_RS08090	COG0812	UDP-N-acetylmuramate dehydrogenase activity
THII_RS08100	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
THII_RS08145	COG0463	Glycosyl transferase, family 2
THII_RS08170	COG1131	(ABC) transporter
THII_RS08175	COG1132	(ABC) transporter
THII_RS08265	COG4137	Cytochrome C assembly protein
THII_RS08300	COG0446	pyridine nucleotide-disulphide oxidoreductase
THII_RS08305	COG2863	cytochrome
THII_RS08315	COG3005	denitrification pathway
THII_RS08320	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
THII_RS08340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THII_RS08350	COG0463	Glycosyl transferase, family 2
THII_RS08350	COG1216	Glycosyl transferase, family 2
THII_RS08380	COG1215	transferase activity, transferring glycosyl groups
THII_RS08390	COG0438	transferase activity, transferring glycosyl groups
THII_RS08395	COG0110	maltose O-acetyltransferase activity
THII_RS08400	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THII_RS08415	COG0297	glycogen (starch) synthase activity
THII_RS08425	COG0247	lactate metabolic process
THII_RS08430	COG0604	alcohol dehydrogenase
THII_RS08445	COG0492	ferredoxin-NADP+ reductase activity
THII_RS08450	COG1459	type II secretion system
THII_RS08510	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THII_RS08515	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THII_RS08520	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THII_RS08535	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THII_RS08545	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
THII_RS08550	COG0575	Belongs to the CDS family
THII_RS08555	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
THII_RS08560	COG0233	cytoplasmic translational termination
THII_RS08565	COG0528	UMP kinase activity
THII_RS08570	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
THII_RS08575	COG0052	Belongs to the universal ribosomal protein uS2 family
THII_RS08580	COG0024	Methionine aminopeptidase
THII_RS08585	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
THII_RS08590	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
THII_RS08595	COG0314	molybdopterin synthase activity
THII_RS08615	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
THII_RS08640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THII_RS08655	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THII_RS08660	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
THII_RS08695	COG0728	peptidoglycan biosynthetic process
THII_RS08700	COG0196	riboflavin kinase activity
THII_RS08720	COG5002	protein histidine kinase activity
THII_RS08725	COG0243	molybdopterin cofactor binding
THII_RS08740	COG2146	nitrite reductase [NAD(P)H] activity
THII_RS08745	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THII_RS08750	COG2223	nitrite transmembrane transporter activity
THII_RS08755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THII_RS08755	COG1116	anion transmembrane transporter activity
THII_RS08760	COG3707	response regulator
THII_RS08780	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
THII_RS08785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THII_RS08805	COG0815	Transfers the fatty acyl group on membrane lipoproteins
THII_RS08815	COG4535	Mg2 and Co2 transporter CorC
THII_RS08820	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
THII_RS08825	COG1702	phosphate starvation-inducible protein PhoH
THII_RS08830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THII_RS08840	COG0037	tRNA processing
THII_RS08855	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THII_RS08870	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
THII_RS08890	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
THII_RS08930	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
THII_RS08955	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THII_RS09000	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THII_RS09015	COG2161	toxin-antitoxin pair type II binding
THII_RS09020	COG4115	mRNA cleavage
THII_RS09025	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
THII_RS09085	COG2920	part of a sulfur-relay system
THII_RS09105	COG0495	leucyl-tRNA aminoacylation
THII_RS09150	COG1049	propionate catabolic process, 2-methylcitrate cycle
THII_RS09190	COG3956	TIGRFAM MazG family protein
THII_RS09205	COG3959	Transketolase, thiamine diphosphate binding domain
THII_RS09210	COG3958	Transketolase
THII_RS09215	COG1850	ribulose-bisphosphate carboxylase activity
THII_RS09225	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THII_RS09235	COG0729	surface antigen
THII_RS09245	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
THII_RS09250	COG2078	PFAM AMMECR1 domain protein
THII_RS09255	COG1355	regulation of microtubule-based process
THII_RS09275	COG1763	Mo-molybdopterin cofactor biosynthetic process
THII_RS09280	COG0746	molybdenum cofactor guanylyltransferase activity
THII_RS09285	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
THII_RS09305	COG1595	DNA-templated transcription, initiation
THII_RS09365	COG0116	Belongs to the methyltransferase superfamily
THII_RS09365	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
THII_RS09370	COG0828	Belongs to the bacterial ribosomal protein bS21 family
THII_RS09390	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
THII_RS09405	COG1215	transferase activity, transferring glycosyl groups
THII_RS09410	COG5001	Diguanylate cyclase
THII_RS09410	COG3300	MHYT domain
THII_RS09415	COG0123	including yeast histone deacetylase and acetoin utilization protein
THII_RS09420	COG0415	Belongs to the DNA photolyase family
THII_RS09430	COG0488	(ABC) transporter
THII_RS09440	COG1394	ATPase activity, coupled to movement of substances
THII_RS09460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
THII_RS09485	COG2198	Histidine kinase
THII_RS09485	COG0784	Response regulator, receiver
THII_RS09485	COG0643	Histidine kinase
THII_RS09490	COG2201	protein-glutamate methylesterase activity
THII_RS09540	COG2442	InterPro IPR007367
THII_RS09575	COG1943	Transposase
THII_RS09630	COG3706	GGDEF domain
THII_RS09645	COG2226	methyltransferase
THII_RS09650	COG2967	ApaG domain
THII_RS09670	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
THII_RS09675	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THII_RS09705	COG1131	(ABC) transporter
THII_RS09745	COG0512	Glutamine amidotransferase of anthranilate synthase
THII_RS09760	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
THII_RS09765	COG0237	dephospho-CoA kinase activity
THII_RS09770	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
THII_RS09800	COG2198	Histidine kinase
THII_RS09800	COG0643	Histidine kinase
THII_RS09800	COG0784	Response regulator, receiver
THII_RS09815	COG1397	ADP-ribosylglycohydrolase
THII_RS10045	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
THII_RS10115	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
THII_RS10120	COG0742	ribosomal rna small subunit methyltransferase
THII_RS10130	COG2203	Gaf domain
THII_RS10130	COG5001	Diguanylate cyclase
THII_RS10130	COG3706	GGDEF domain
THII_RS10130	COG4251	negative regulation of phosphorylation
THII_RS10145	COG0741	lytic transglycosylase activity
THII_RS10150	COG4717	serine-type aminopeptidase activity
THII_RS10165	COG0420	3'-5' exonuclease activity
THII_RS10195	COG1560	Kdo2-lipid A biosynthetic process
THII_RS10205	COG1459	type II secretion system
THII_RS10245	COG0438	transferase activity, transferring glycosyl groups
THII_RS10250	COG3158	transport of potassium into the cell
THII_RS10265	COG0189	ligase activity
THII_RS10270	COG0404	The glycine cleavage system catalyzes the degradation of glycine
THII_RS10275	COG0509	glycine decarboxylation via glycine cleavage system
THII_RS10280	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THII_RS10290	COG2205	protein histidine kinase activity
THII_RS10310	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
THII_RS10350	COG1028	Short-chain dehydrogenase reductase Sdr
THII_RS10350	COG3347	Dehydrogenase
THII_RS10360	COG3267	Type II secretory pathway component ExeA
THII_RS10360	COG3409	Peptidoglycan-binding domain 1 protein
THII_RS10380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
THII_RS10385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THII_RS10390	COG0271	Belongs to the BolA IbaG family
THII_RS10395	COG2350	Protein conserved in bacteria
THII_RS10400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THII_RS10405	COG2917	probably involved in intracellular septation
THII_RS10415	COG1127	ABC transporter
THII_RS10420	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
THII_RS10440	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
THII_RS10445	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
THII_RS10465	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
THII_RS10480	COG0318	PFAM AMP-dependent synthetase and ligase
THII_RS10480	COG0204	Acyl-transferase
THII_RS10495	COG3657	addiction module killer protein
THII_RS10500	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
THII_RS10520	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
THII_RS10530	COG4636	protein conserved in cyanobacteria
THII_RS10540	COG0475	glutathione-regulated potassium exporter activity
THII_RS10540	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
THII_RS10555	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
THII_RS10620	COG1819	glycosyl
THII_RS10665	COG4659	FMN binding
THII_RS10675	COG4656	Part of a membrane complex involved in electron transport
THII_RS10680	COG2878	Part of a membrane complex involved in electron transport
THII_RS10685	COG4657	Part of a membrane complex involved in electron transport
THII_RS10705	COG4999	Histidine kinase
THII_RS10705	COG3850	Histidine kinase
THII_RS10705	COG3437	response regulator, receiver
THII_RS10705	COG2205	protein histidine kinase activity
THII_RS10710	COG0736	holo-[acyl-carrier-protein] synthase activity
THII_RS10715	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
THII_RS10725	COG1538	Outer membrane efflux protein
THII_RS10735	COG0840	transmembrane signaling receptor activity
THII_RS10740	COG0835	chemotaxis
THII_RS10745	COG0643	Histidine kinase
THII_RS10745	COG2198	Histidine kinase
THII_RS10750	COG0745	RESPONSE REGULATOR receiver
THII_RS10765	COG0084	hydrolase, TatD family'
THII_RS10780	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
THII_RS10785	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
THII_RS10800	COG0840	transmembrane signaling receptor activity
THII_RS10830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THII_RS10860	COG4221	oxidoreductase activity
THII_RS10860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
THII_RS10860	COG1028	Short-chain dehydrogenase reductase Sdr
THII_RS10860	COG3321	synthase
THII_RS10865	COG3321	synthase
THII_RS10865	COG4221	oxidoreductase activity
THII_RS10865	COG3321	synthase
THII_RS10865	COG1028	Short-chain dehydrogenase reductase Sdr
THII_RS10865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
THII_RS10865	COG1028	Short-chain dehydrogenase reductase Sdr
THII_RS10865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
THII_RS10865	COG4221	oxidoreductase activity
THII_RS10875	COG1250	3-hydroxyacyl-CoA dehydrogenase
THII_RS10885	COG1960	acyl-CoA dehydrogenase activity
THII_RS10895	COG4221	oxidoreductase activity
THII_RS10895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THII_RS10895	COG3321	synthase
THII_RS10895	COG0300	oxidoreductase activity
THII_RS10900	COG4221	oxidoreductase activity
THII_RS10900	COG3321	synthase
THII_RS10900	COG1028	Short-chain dehydrogenase reductase Sdr
THII_RS10900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
THII_RS10940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THII_RS10955	COG3425	synthase
THII_RS10960	COG1024	Enoyl-CoA hydratase
THII_RS11045	COG0574	Belongs to the PEP-utilizing enzyme family
THII_RS11045	COG3848	Pyruvate phosphate dikinase
THII_RS11075	COG2217	Heavy metal translocating P-type atpase
THII_RS11105	COG3335	DDE superfamily endonuclease
THII_RS11150	COG1160	GTP binding
THII_RS11165	COG1450	Type ii and iii secretion system protein
THII_RS11170	COG1459	type II secretion system
THII_RS11175	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THII_RS11185	COG0525	valine-tRNA ligase activity
THII_RS11235	COG2379	hydroxypyruvate reductase
THII_RS11245	COG1233	COG1233 Phytoene dehydrogenase and related
THII_RS11255	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
THII_RS11260	COG2048	Heterodisulfide reductase, subunit B
THII_RS11295	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
THII_RS11300	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
THII_RS11310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
THII_RS11315	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
THII_RS11335	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
THII_RS11350	COG0438	transferase activity, transferring glycosyl groups
THII_RS11355	COG0463	Glycosyl transferase, family 2
THII_RS11365	COG0367	asparagine synthase
THII_RS11375	COG0012	GTP binding
THII_RS11380	COG0193	aminoacyl-tRNA hydrolase activity
THII_RS11385	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
THII_RS11390	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
THII_RS11400	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
THII_RS11405	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
THII_RS11415	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THII_RS11420	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
THII_RS11430	COG2304	oxidoreductase activity
THII_RS11435	COG1032	radical SAM domain protein
THII_RS11480	COG2205	protein histidine kinase activity
THII_RS11480	COG0784	Response regulator, receiver
THII_RS11485	COG1183	phosphatidylcholine synthase activity
THII_RS11490	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
THII_RS11515	COG0028	Belongs to the TPP enzyme family
THII_RS11550	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
THII_RS11555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THII_RS11560	COG1773	rubredoxin
THII_RS11565	COG1992	Thiamine-phosphate synthase
THII_RS11565	COG0351	phosphomethylpyrimidine kinase
THII_RS11570	COG0352	thiamine-phosphate diphosphorylase activity
THII_RS11575	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
THII_RS11600	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THII_RS11600	COG0517	IMP dehydrogenase activity
THII_RS11600	COG0617	tRNA 3'-terminal CCA addition
THII_RS11605	COG0432	Pfam Uncharacterised protein family UPF0047
THII_RS11635	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
THII_RS11650	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THII_RS11655	COG0218	Necessary for normal cell division and for the maintenance of normal septation
THII_RS11660	COG0542	response to heat
THII_RS11665	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
THII_RS11685	COG3178	'Phosphotransferase
THII_RS11690	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
THII_RS11695	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
THII_RS11700	COG0291	Belongs to the bacterial ribosomal protein bL35 family
THII_RS11705	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
THII_RS11710	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THII_RS11735	COG2205	protein histidine kinase activity
THII_RS11735	COG0784	Response regulator, receiver
THII_RS11735	COG5002	protein histidine kinase activity
THII_RS11750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THII_RS11770	COG4636	protein conserved in cyanobacteria
THII_RS11810	COG1923	regulation of RNA biosynthetic process
THII_RS11815	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
THII_RS11820	COG0330	HflC and HflK could
THII_RS11825	COG0330	HflC and HflK could
THII_RS11830	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
THII_RS11835	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
THII_RS11840	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
THII_RS11890	COG0745	RESPONSE REGULATOR receiver
THII_RS11895	COG2770	Histidine kinase
THII_RS11895	COG2205	protein histidine kinase activity
THII_RS11925	COG4660	Part of a membrane complex involved in electron transport
THII_RS11935	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THII_RS11940	COG0357	Ribosomal RNA small subunit methyltransferase G
THII_RS11985	COG0129	dihydroxy-acid dehydratase activity
THII_RS12000	COG0758	DNA mediated transformation
THII_RS12005	COG2922	Belongs to the Smg family
THII_RS12015	COG0009	L-threonylcarbamoyladenylate synthase
THII_RS12020	COG0347	Belongs to the P(II) protein family
THII_RS12025	COG0004	ammonium transporteR
THII_RS12030	COG2885	chlorophyll binding
THII_RS12050	COG0484	heat shock protein binding
THII_RS12070	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
THII_RS12085	COG0840	transmembrane signaling receptor activity
THII_RS12105	COG1139	Iron-sulfur cluster binding protein
THII_RS12175	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
THII_RS12180	COG3584	3D domain protein
THII_RS12180	COG1388	LysM domain
THII_RS12240	COG0861	Integral membrane protein TerC family
THII_RS12250	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
THII_RS12255	COG2165	general secretion pathway protein
THII_RS12295	COG1028	Short-chain dehydrogenase reductase Sdr
THII_RS12310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THII_RS12320	COG0481	GTPase activity
THII_RS12325	COG0681	Belongs to the peptidase S26 family
THII_RS12335	COG0571	ribonuclease III activity
THII_RS12340	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
THII_RS12370	COG2267	carboxylic ester hydrolase activity
THII_RS12390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THII_RS12395	COG2048	Heterodisulfide reductase, subunit B
THII_RS12425	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THII_RS12470	COG2914	Belongs to the UPF0125 (RnfH) family
THII_RS12495	COG1272	protein, Hemolysin III
THII_RS12505	COG0714	Associated with various cellular activities
THII_RS12515	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
THII_RS12520	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THII_RS12525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THII_RS12530	COG0812	UDP-N-acetylmuramate dehydrogenase activity
THII_RS12535	COG1181	Belongs to the D-alanine--D-alanine ligase family
THII_RS12540	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
THII_RS12555	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
THII_RS12585	COG1045	serine acetyltransferase
THII_RS12605	COG3713	MltA-interacting MipA family protein
THII_RS12620	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
THII_RS12625	COG1968	undecaprenyl-diphosphatase activity
THII_RS12635	COG1229	Formylmethanofuran dehydrogenase subunit A
THII_RS12680	COG2914	Belongs to the UPF0125 (RnfH) family
THII_RS12695	COG4658	electron transport chain
THII_RS12700	COG4656	Part of a membrane complex involved in electron transport
THII_RS12705	COG2878	Part of a membrane complex involved in electron transport
THII_RS12710	COG4657	Part of a membrane complex involved in electron transport
THII_RS12730	COG1487	ribonuclease activity
THII_RS12760	COG5000	phosphorelay sensor kinase activity
THII_RS12765	COG2204	response regulator
THII_RS12800	COG3093	addiction module antidote protein HigA
THII_RS12840	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THII_RS12845	COG0825	malonyl-CoA metabolic process
THII_RS12850	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
THII_RS12855	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
THII_RS12860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THII_RS12885	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
THII_RS12890	COG4208	sulfate ABC transporter
THII_RS12895	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
THII_RS12915	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
THII_RS12920	COG0563	adenylate kinase activity
THII_RS12950	COG3335	DDE superfamily endonuclease
THII_RS12965	COG0574	Belongs to the PEP-utilizing enzyme family
THII_RS12965	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THII_RS13010	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
THII_RS13055	COG0438	transferase activity, transferring glycosyl groups
THII_RS13060	COG0297	glycogen (starch) synthase activity
THII_RS13080	COG1022	Amp-dependent synthetase and ligase
THII_RS13085	COG3942	CHAP domain
THII_RS13085	COG1388	LysM domain
THII_RS13090	COG3942	CHAP domain
THII_RS13090	COG1388	LysM domain
THII_RS13100	COG0737	Belongs to the 5'-nucleotidase family
THII_RS13105	COG1230	cation diffusion facilitator family transporter
THII_RS13110	COG0586	Pfam SNARE associated Golgi protein
THII_RS13170	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THII_RS13175	COG0596	Alpha beta hydrolase
THII_RS13185	COG3335	DDE superfamily endonuclease
THII_RS13205	COG0430	RNA-3'-phosphate cyclase activity
THII_RS13230	COG3154	lipid carrier protein
THII_RS13235	COG0826	peptidase U32
THII_RS13240	COG0826	peptidase U32
THII_RS13245	COG1242	4 iron, 4 sulfur cluster binding
THII_RS13305	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
THII_RS13310	COG1519	Transferase
THII_RS13325	COG0747	negative chemotaxis
THII_RS13330	COG3706	GGDEF domain
THII_RS13350	COG0488	(ABC) transporter
THII_RS13355	COG4636	protein conserved in cyanobacteria
THII_RS13405	COG1192	Involved in chromosome partitioning
THII_RS13415	COG0484	heat shock protein binding
THII_RS13420	COG0443	Heat shock 70 kDa protein
THII_RS13425	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THII_RS13430	COG1420	regulation of RNA biosynthetic process
THII_RS13435	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
THII_RS13440	COG2915	High frequency lysogenization protein hflD homolog
THII_RS13460	COG0482	sulfurtransferase activity
THII_RS13475	COG0303	'Molybdopterin
THII_RS13510	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THII_RS13520	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THII_RS13530	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
THII_RS13535	COG0081	regulation of translation
THII_RS13540	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
THII_RS13545	COG0222	ribosome binding
THII_RS13550	COG0085	RNA polymerase activity
THII_RS13555	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
THII_RS13570	COG1131	(ABC) transporter
THII_RS13575	COG0842	Transport permease protein
THII_RS13585	COG1136	(ABC) transporter
THII_RS13620	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
THII_RS13625	COG0752	glycyl-tRNA synthetase alpha subunit
THII_RS13630	COG0751	glycine-tRNA ligase activity
THII_RS13640	COG0756	dUTP diphosphatase activity
THII_RS13660	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THII_RS13665	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
THII_RS13700	COG1278	Cold shock
THII_RS13705	COG0277	FAD linked oxidase domain protein
THII_RS13740	COG3293	Transposase
THII_RS13755	COG3597	protein domain associated with
THII_RS13790	COG3119	arylsulfatase activity
THII_RS13795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THII_RS13795	COG3320	Male sterility
THII_RS13850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THII_RS13860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
THII_RS13875	COG2192	nodulation
THII_RS13880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THII_RS13890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THII_RS13900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
THII_RS13905	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
THII_RS13925	COG1490	D-aminoacyl-tRNA deacylase activity
THII_RS13930	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
THII_RS13940	COG2914	Belongs to the UPF0125 (RnfH) family
THII_RS13950	COG0735	belongs to the Fur family
THII_RS14000	COG0328	RNA-DNA hybrid ribonuclease activity
THII_RS14005	COG2226	methyltransferase
THII_RS14010	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
THII_RS14015	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THII_RS14050	COG2814	Major facilitator Superfamily
THII_RS14060	COG2197	response regulator
THII_RS14070	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
THII_RS14075	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
THII_RS14090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THII_RS14120	COG2314	TM2 domain
THII_RS14275	COG0535	radical SAM domain protein
THII_RS14285	COG4263	nitrous-oxide reductase activity
THII_RS14310	COG0437	4 iron, 4 sulfur cluster binding
THII_RS14320	COG1131	(ABC) transporter
THII_RS14385	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THII_RS14400	COG1660	Displays ATPase and GTPase activities
THII_RS14405	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
THII_RS14410	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THII_RS14415	COG0504	CTP synthase activity
THII_RS14425	COG0261	This protein binds to 23S rRNA in the presence of protein L20
THII_RS14430	COG0211	Belongs to the bacterial ribosomal protein bL27 family
THII_RS14435	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THII_RS14455	COG1475	DNA binding
THII_RS14470	COG3041	Addiction module toxin RelE StbE family
THII_RS14500	COG0355	proton-transporting ATP synthase activity, rotational mechanism
THII_RS14505	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
THII_RS14510	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
THII_RS14520	COG0307	riboflavin synthase, alpha
THII_RS14525	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
THII_RS14530	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THII_RS14535	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
THII_RS14540	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THII_RS14545	COG0356	it plays a direct role in the translocation of protons across the membrane
THII_RS14570	COG1007	ATP synthesis coupled electron transport
THII_RS14585	COG0713	ATP synthesis coupled electron transport
THII_RS14605	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THII_RS14610	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
THII_RS14615	COG1034	ATP synthesis coupled electron transport
THII_RS14640	COG0159	tryptophan synthase activity
THII_RS14645	COG0133	tryptophan synthase activity
THII_RS14670	COG0708	Exodeoxyribonuclease III
THII_RS14695	COG0215	cysteine-tRNA ligase activity
THII_RS14700	COG2205	protein histidine kinase activity
THII_RS14745	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
THII_RS14750	COG2204	response regulator
THII_RS14755	COG0268	Binds directly to 16S ribosomal RNA
THII_RS14775	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
THII_RS14775	COG4797	methyltransferase
THII_RS14780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THII_RS14840	COG0018	arginyl-trna synthetase
THII_RS14845	COG4115	mRNA cleavage
THII_RS14945	COG0497	DNA recombination
THII_RS14955	COG0277	FAD linked oxidase domain protein
THII_RS14960	COG0047	phosphoribosylformylglycinamidine synthase activity
THII_RS14960	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THII_RS14970	COG0402	S-adenosylhomocysteine deaminase activity
THII_RS14975	COG1902	pentaerythritol trinitrate reductase activity
THII_RS15050	COG0631	protein serine/threonine phosphatase activity
THII_RS15055	COG0631	protein serine/threonine phosphatase activity
THII_RS15060	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
THII_RS15075	COG4251	negative regulation of phosphorylation
THII_RS15075	COG5001	Diguanylate cyclase
THII_RS15075	COG2203	Gaf domain
THII_RS15075	COG3706	GGDEF domain
THII_RS15085	COG1388	LysM domain
THII_RS15085	COG1470	cell adhesion involved in biofilm formation
THII_RS15110	COG1466	dna polymerase III delta subunit
THII_RS15120	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THII_RS15125	COG0546	phosphoglycolate phosphatase activity
THII_RS15125	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
THII_RS15150	COG0662	Cupin 2, conserved barrel domain protein
THII_RS15150	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
THII_RS15160	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
THII_RS15165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THII_RS15225	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
THII_RS15235	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THII_RS15240	COG0488	(ABC) transporter
THII_RS15265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THII_RS15265	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THII_RS15270	COG2104	thiamine diphosphate biosynthetic process
THII_RS15270	COG2022	thiamine diphosphate biosynthetic process
THII_RS15325	COG1331	Highly conserved protein containing a thioredoxin domain
THII_RS15330	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THII_RS15335	COG2204	response regulator
THII_RS15340	COG3267	Type II secretory pathway component ExeA
THII_RS15340	COG3409	Peptidoglycan-binding domain 1 protein
THII_RS15350	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
THII_RS15355	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THII_RS15360	COG0557	exoribonuclease II activity
THII_RS15380	COG4536	flavin adenine dinucleotide binding
THII_RS15430	COG0577	efflux transmembrane transporter activity
THII_RS15430	COG1136	(ABC) transporter
THII_RS15435	COG1136	(ABC) transporter
THII_RS15435	COG0577	efflux transmembrane transporter activity
THII_RS15465	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
THII_RS15470	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THII_RS15480	COG0438	transferase activity, transferring glycosyl groups
THII_RS15500	COG0633	Ferredoxin
THII_RS15505	COG0426	domain, Protein
THII_RS15510	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
THII_RS15535	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THII_RS15540	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THII_RS15550	COG0189	ligase activity
THII_RS15560	COG0667	Aldo Keto reductase
THII_RS15565	COG4249	Peptidase C14 caspase catalytic subunit p20
THII_RS15565	COG2319	Wd-40 repeat
THII_RS15570	COG4249	Peptidase C14 caspase catalytic subunit p20
THII_RS15570	COG2319	Wd-40 repeat
THII_RS15595	COG0784	Response regulator, receiver
THII_RS15595	COG2205	protein histidine kinase activity
THII_RS15595	COG2198	Histidine kinase
THII_RS15605	COG3549	Plasmid maintenance system killer
THII_RS15625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THII_RS15635	COG0501	Belongs to the peptidase M48B family
THII_RS15640	COG4636	protein conserved in cyanobacteria
THII_RS15655	COG1562	ergosterol biosynthetic process
THII_RS15685	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
THII_RS15690	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
THII_RS15705	COG1138	Cytochrome C-type biogenesis protein
THII_RS15710	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
THII_RS15715	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
THII_RS15745	COG1127	ABC transporter
THII_RS15765	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THII_RS15765	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
THII_RS15805	COG0826	peptidase U32
THII_RS15810	COG1166	arginine decarboxylase activity
THII_RS15840	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
THII_RS15880	COG4658	electron transport chain
THII_RS15915	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THII_RS15930	COG4636	protein conserved in cyanobacteria
THII_RS15940	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
THII_RS15985	COG0439	Biotin carboxylase
THII_RS15990	COG0511	ligase activity, forming carbon-carbon bonds
THII_RS15995	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
THII_RS16015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THII_RS16035	COG2840	Smr protein MutS2
THII_RS16040	COG0181	hydroxymethylbilane synthase activity
THII_RS16075	COG3459	Glycosyltransferase 36 associated
THII_RS16110	COG3237	CsbD-like
THII_RS16130	COG3088	subunit of a heme lyase
THII_RS16165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THII_RS16180	COG0243	molybdopterin cofactor binding
THII_RS16185	COG0437	4 iron, 4 sulfur cluster binding
THII_RS16265	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
THII_RS16270	COG0850	regulation of cytokinetic process
THII_RS16275	COG2894	cell division
THII_RS16280	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
THII_RS16300	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
THII_RS16305	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
THII_RS16305	COG2813	Specifically methylates the guanine in position
THII_RS16310	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
THII_RS16315	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
THII_RS16360	COG2161	toxin-antitoxin pair type II binding
THII_RS16390	COG0450	alkyl hydroperoxide reductase
THII_RS16410	COG3246	L-lysine catabolic process to acetate
THII_RS16415	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
THII_RS16425	COG0583	DNA-binding transcription factor activity
THII_RS16430	COG1850	ribulose-bisphosphate carboxylase activity
THII_RS16450	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
THII_RS16455	COG2226	methyltransferase
THII_RS16480	COG0573	inorganic phosphate transmembrane transporter activity
THII_RS16490	COG0720	synthase
THII_RS16525	COG0432	Pfam Uncharacterised protein family UPF0047
THII_RS16570	COG0469	pyruvate kinase activity
THII_RS16575	COG0126	phosphoglycerate kinase activity
THII_RS16580	COG0267	Belongs to the bacterial ribosomal protein bL33 family
THII_RS16600	COG2198	Histidine kinase
THII_RS16600	COG0784	Response regulator, receiver
THII_RS16600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THII_RS16600	COG2205	protein histidine kinase activity
THII_RS16610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THII_RS16625	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THII_RS16630	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
THII_RS16680	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
THII_RS16685	COG0045	succinate-CoA ligase (ADP-forming) activity
THII_RS16695	COG0124	histidyl-tRNA synthetase
THII_RS16700	COG2976	Protein conserved in bacteria
THII_RS16735	COG2770	Histidine kinase
THII_RS16735	COG2208	phosphoserine phosphatase activity
THII_RS16805	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THII_RS16810	COG1605	Chorismate mutase
THII_RS16810	COG0077	Prephenate dehydratase
THII_RS16820	COG0590	tRNA wobble adenosine to inosine editing
THII_RS16830	COG0300	oxidoreductase activity
THII_RS16855	COG0436	Aminotransferase
THII_RS16885	COG0149	triose-phosphate isomerase activity
THII_RS16895	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
THII_RS16900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
THII_RS16920	COG1981	membrane
THII_RS16925	COG0194	GDP metabolic process
THII_RS16930	COG1561	YicC-like family, N-terminal region
THII_RS16935	COG2198	Histidine kinase
THII_RS16935	COG5002	protein histidine kinase activity
THII_RS16935	COG0784	Response regulator, receiver
THII_RS16960	COG5001	Diguanylate cyclase
THII_RS16965	COG1217	gtp-binding protein TYPA
THII_RS16975	COG0842	Transport permease protein
THII_RS16975	COG1131	(ABC) transporter
THII_RS16975	COG1716	ATPase activity
THII_RS16980	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
THII_RS16985	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
THII_RS17015	COG1530	ribonuclease E activity
THII_RS17020	COG0564	pseudouridine synthase activity
THII_RS17030	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
THII_RS17030	COG0616	signal peptide processing
THII_RS17040	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THII_RS17045	COG1993	acr, cog1993
THII_RS17050	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THII_RS17055	COG1993	acr, cog1993
THII_RS17060	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
THII_RS17090	COG0508	dehydrogenase complex catalyzes the overall conversion of
THII_RS17100	COG0039	L-malate dehydrogenase activity
THII_RS17145	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
THII_RS17150	COG0305	Participates in initiation and elongation during chromosome replication
THII_RS17150	COG1372	Participates in initiation and elongation during chromosome replication
THII_RS17155	COG0359	binds to the 23S rRNA
THII_RS17160	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
THII_RS17165	COG0360	Binds together with S18 to 16S ribosomal RNA
THII_RS17175	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
THII_RS17180	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
THII_RS17185	COG0180	Tryptophanyl-tRNA synthetase
THII_RS17190	COG1994	Peptidase M50
THII_RS17195	COG0009	L-threonylcarbamoyladenylate synthase
THII_RS17200	COG0220	tRNA (guanine-N7-)-methyltransferase activity
THII_RS17210	COG2198	Histidine kinase
THII_RS17210	COG0784	Response regulator, receiver
THII_RS17210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THII_RS17210	COG2205	protein histidine kinase activity
THII_RS17220	COG0312	modulator of DNA gyrase
THII_RS17235	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
THII_RS17270	COG0156	8-amino-7-oxononanoate synthase activity
THII_RS17280	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
THII_RS17295	COG0442	prolyl-tRNA aminoacylation
THII_RS17300	COG4953	penicillin-binding protein 1C
THII_RS17315	COG0297	glycogen (starch) synthase activity
THII_RS17325	COG0859	PFAM glycosyl transferase family 9
THII_RS17335	COG0297	glycogen (starch) synthase activity
THII_RS17370	COG0508	dehydrogenase complex catalyzes the overall conversion of
THII_RS17415	COG2921	Belongs to the UPF0250 family
THII_RS17420	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
THII_RS17425	COG1686	Belongs to the peptidase S11 family
THII_RS17430	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
THII_RS17430	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
THII_RS17435	COG2951	lytic endotransglycosylase activity
THII_RS17440	COG0772	Belongs to the SEDS family
THII_RS17445	COG0768	penicillin binding
THII_RS17450	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
THII_RS17455	COG1792	Involved in formation and maintenance of cell shape
THII_RS17460	COG1077	Cell shape determining protein MreB Mrl
THII_RS17470	COG0154	amidase activity
THII_RS17475	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THII_RS17505	COG0717	Belongs to the dCTP deaminase family
THII_RS17510	COG0489	protein tyrosine kinase activity
THII_RS17515	COG0517	IMP dehydrogenase activity
THII_RS17530	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
THII_RS17555	COG2321	neutral zinc metallopeptidase
THII_RS17580	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
THII_RS17585	COG0298	carbon dioxide binding
THII_RS17590	COG0375	protein maturation
THII_RS17600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THII_RS17605	COG0142	geranyltranstransferase activity
THII_RS17620	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
THII_RS17635	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
THII_RS17700	COG0842	Transport permease protein
THII_RS17705	COG1131	(ABC) transporter
THII_RS17720	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
THII_RS17725	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
THII_RS17725	COG1672	PFAM Archaeal ATPase
THII_RS17745	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THII_RS17755	COG0367	asparagine synthase
THII_RS17770	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
THII_RS17780	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
THII_RS17785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THII_RS17790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THII_RS17795	COG1028	Short-chain dehydrogenase reductase Sdr
THII_RS17805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THII_RS17810	COG0416	fatty acid biosynthetic process
THII_RS17815	COG0333	Belongs to the bacterial ribosomal protein bL32 family
THII_RS17820	COG1399	metal-binding, possibly nucleic acid-binding protein
THII_RS17825	COG0424	maF-like protein
THII_RS17830	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
THII_RS17845	COG2217	Heavy metal translocating P-type atpase
THII_RS17850	COG2084	Dehydrogenase
THII_RS17855	COG0210	DNA helicase
THII_RS17860	COG0531	amino acid
THII_RS17915	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
THII_RS17930	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
THII_RS17940	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
THII_RS17945	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THII_RS17950	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
THII_RS17975	COG0134	indole-3-glycerol-phosphate synthase activity
THII_RS17980	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THII_RS17985	COG0471	metal ion transport
THII_RS17985	COG3273	potassium ion transport
THII_RS17995	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
THII_RS18000	COG0484	heat shock protein binding
THII_RS18005	COG0148	phosphopyruvate hydratase activity
THII_RS18010	COG2877	3-deoxy-8-phosphooctulonate synthase activity
THII_RS18020	COG0693	protein deglycase activity
THII_RS18050	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
THII_RS18060	COG2943	transferase activity, transferring hexosyl groups
THII_RS18065	COG2234	aminopeptidase activity
THII_RS18125	COG0535	radical SAM domain protein
THII_RS18135	COG0589	response to stress
THII_RS18145	COG0501	Belongs to the peptidase M48B family
THII_RS18155	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THII_RS18155	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
THII_RS18160	COG0802	atpase or kinase
THII_RS18210	COG3293	Transposase
THII_RS18225	COG0409	Hydrogenase expression formation protein
THII_RS18300	COG0493	'glutamate synthase
THII_RS18310	COG1013	pyruvate-flavodoxin oxidoreductase activity
THII_RS18315	COG0674	pyruvate-flavodoxin oxidoreductase activity
THII_RS18350	COG0546	phosphoglycolate phosphatase activity
THII_RS18355	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
THII_RS18370	COG0754	glutathionylspermidine amidase activity
THII_RS18375	COG0724	RNA recognition motif
THII_RS18385	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THII_RS18405	COG0248	Ppx GppA phosphatase
THII_RS18415	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
THII_RS18420	COG0019	diaminopimelate decarboxylase activity
THII_RS18430	COG2192	nodulation
THII_RS18450	COG0167	dihydroorotate dehydrogenase activity
THII_RS18455	COG2183	response to ionizing radiation
THII_RS18470	COG0070	glutamate synthase
THII_RS18470	COG0069	glutamate synthase activity
THII_RS18470	COG0067	glutamate synthase
THII_RS18500	COG2205	protein histidine kinase activity
THII_RS18500	COG0784	Response regulator, receiver
THII_RS18515	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THII_RS18515	COG0519	Catalyzes the synthesis of GMP from XMP
THII_RS18525	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
THII_RS18615	COG3335	DDE superfamily endonuclease
THII_RS18640	COG0556	nucleotide-excision repair
THII_RS18645	COG0436	Aminotransferase
THII_RS18660	COG0445	tRNA wobble uridine modification
THII_RS18665	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THII_RS18670	COG1573	uracil-dna glycosylase
THII_RS18700	COG2195	Cleaves the N-terminal amino acid of tripeptides
THII_RS18735	COG0588	phosphoglycerate mutase activity
THII_RS18740	COG4942	peptidase
THII_RS18745	COG0793	Belongs to the peptidase S41A family
THII_RS18755	COG0372	Belongs to the citrate synthase family
THII_RS18790	COG2815	serine threonine protein kinase
THII_RS18790	COG0515	serine threonine protein kinase
THII_RS18800	COG4251	negative regulation of phosphorylation
THII_RS18800	COG3706	GGDEF domain
THII_RS18800	COG2203	Gaf domain
THII_RS18800	COG5001	Diguanylate cyclase
THII_RS18840	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THII_RS18845	COG2852	Protein conserved in bacteria
THII_RS18865	COG0475	glutathione-regulated potassium exporter activity
THII_RS18870	COG2154	pterin-4-alpha-carbinolamine dehydratase
THII_RS18880	COG1797	cobyrinic acid a,c-diamide synthase activity
THII_RS18885	COG2885	chlorophyll binding
THII_RS18915	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
THII_RS18920	COG3162	membrane
THII_RS18945	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
THII_RS18970	COG1324	tolerance protein
THII_RS18975	COG4232	protein-disulfide reductase activity
THII_RS18980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THII_RS19010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THII_RS19010	COG2205	protein histidine kinase activity
THII_RS19015	COG1528	Iron-storage protein
THII_RS19025	COG0242	peptide deformylase activity
THII_RS19090	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
THII_RS19125	COG0745	RESPONSE REGULATOR receiver
THII_RS19135	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
THII_RS19140	COG1196	nuclear chromosome segregation
THII_RS19140	COG0741	lytic transglycosylase activity
THII_RS19140	COG0739	heme binding
THII_RS19155	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
THII_RS19180	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
THII_RS19190	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
THII_RS19205	COG2204	response regulator
THII_RS19210	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
THII_RS19240	COG0228	four-way junction DNA binding
THII_RS19245	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
THII_RS19255	COG0335	large ribosomal subunit rRNA binding
THII_RS19300	COG0330	HflC and HflK could
THII_RS19305	COG0653	protein targeting
THII_RS19320	COG0456	acetyltransferase
THII_RS19325	COG1573	uracil-dna glycosylase
THII_RS19330	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THII_RS19335	COG1765	OsmC-like protein
THII_RS19345	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
THII_RS19350	COG1234	tRNA 3'-trailer cleavage
THII_RS19370	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
THII_RS19375	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
THII_RS19375	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
THII_RS19380	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
THII_RS19400	COG4172	Belongs to the ABC transporter superfamily
THII_RS19410	COG1560	Kdo2-lipid A biosynthetic process
THII_RS19425	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
THII_RS19480	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THII_RS19535	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
THII_RS19540	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
THII_RS19555	COG0137	argininosuccinate synthase activity
THII_RS19570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THII_RS19575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THII_RS19585	COG3023	N-Acetylmuramoyl-L-alanine amidase
THII_RS19600	COG1842	Phage shock protein A
THII_RS19655	COG0463	Glycosyl transferase, family 2
THII_RS19715	COG1846	Transcriptional regulator
THII_RS19750	COG2815	serine threonine protein kinase
THII_RS19750	COG0515	serine threonine protein kinase
THII_RS19755	COG0784	Response regulator, receiver
THII_RS19755	COG2205	protein histidine kinase activity
THII_RS19755	COG5002	protein histidine kinase activity
THII_RS19765	COG1404	Belongs to the peptidase S8 family
THII_RS19785	COG0784	Response regulator, receiver
THII_RS19785	COG2205	protein histidine kinase activity
THII_RS19805	COG1999	signal sequence binding
THII_RS19830	COG5002	protein histidine kinase activity
THII_RS19830	COG0784	Response regulator, receiver
THII_RS19830	COG2205	protein histidine kinase activity
THII_RS19850	COG3527	Alpha-acetolactate decarboxylase
THII_RS19860	COG0438	transferase activity, transferring glycosyl groups
THII_RS19860	COG1216	Glycosyl transferase, family 2
THII_RS19875	COG2198	Histidine kinase
THII_RS19875	COG0784	Response regulator, receiver
THII_RS19875	COG5002	protein histidine kinase activity
THII_RS19925	COG1388	LysM domain
THII_RS19925	COG0741	lytic transglycosylase activity
THII_RS19935	COG0840	transmembrane signaling receptor activity
THII_RS19990	COG0745	RESPONSE REGULATOR receiver
THII_RS19990	COG2205	protein histidine kinase activity
THII_RS19990	COG4191	Histidine kinase
THII_RS19995	COG2205	protein histidine kinase activity
THII_RS19995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THII_RS20015	COG2226	methyltransferase
THII_RS20045	COG2202	Pas domain
THII_RS20045	COG2205	protein histidine kinase activity
THII_RS20055	COG5002	protein histidine kinase activity
THII_RS20055	COG2205	protein histidine kinase activity
THII_RS20055	COG0784	Response regulator, receiver
THII_RS20080	COG0515	serine threonine protein kinase
THII_RS20080	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THII_RS20100	COG5002	protein histidine kinase activity
THII_RS20100	COG0784	Response regulator, receiver
THII_RS20100	COG2205	protein histidine kinase activity
THII_RS20105	COG0741	lytic transglycosylase activity
THII_RS20105	COG1196	nuclear chromosome segregation
THII_RS20105	COG0739	heme binding
THII_RS20120	COG0784	Response regulator, receiver
THII_RS20120	COG2205	protein histidine kinase activity
THII_RS20135	COG3437	response regulator, receiver
THII_RS20135	COG0784	Response regulator, receiver
THII_RS20150	COG2198	Histidine kinase
THII_RS20150	COG5002	protein histidine kinase activity
THII_RS20150	COG0784	Response regulator, receiver
THII_RS20195	COG2203	Gaf domain
THII_RS20195	COG4251	negative regulation of phosphorylation
THII_RS20195	COG5001	Diguanylate cyclase
THII_RS20195	COG3706	GGDEF domain
THII_RS20235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THII_RS20235	COG0784	Response regulator, receiver
THII_RS20235	COG2205	protein histidine kinase activity
THII_RS20235	COG2198	Histidine kinase
THII_RS20255	COG0840	transmembrane signaling receptor activity
THII_RS20260	COG0463	Glycosyl transferase, family 2
THII_RS20280	COG0784	Response regulator, receiver
THII_RS20280	COG2205	protein histidine kinase activity
THII_RS20295	COG0840	transmembrane signaling receptor activity
THII_RS20345	COG2319	Wd-40 repeat
THII_RS20345	COG4249	Peptidase C14 caspase catalytic subunit p20
THII_RS20355	COG2205	protein histidine kinase activity
THII_RS20355	COG3437	response regulator, receiver
THII_RS20355	COG3850	Histidine kinase
THII_RS20355	COG4999	Histidine kinase
THII_RS20390	COG2205	protein histidine kinase activity
THII_RS20390	COG0784	Response regulator, receiver
THII_RS20405	COG0484	heat shock protein binding
THII_RS20415	COG2205	protein histidine kinase activity
THII_RS20415	COG3437	response regulator, receiver
THII_RS20415	COG3850	Histidine kinase
THII_RS20415	COG4999	Histidine kinase
THII_RS20420	COG0840	transmembrane signaling receptor activity
THII_RS20455	COG5002	protein histidine kinase activity
THII_RS20455	COG0784	Response regulator, receiver
THII_RS20460	COG0739	heme binding
THII_RS20485	COG1555	photosystem II stabilization
THII_RS20490	COG1404	Belongs to the peptidase S8 family
THII_RS20510	COG0641	radical SAM
THII_RS20525	COG2264	protein methyltransferase activity
THII_RS20560	COG2203	Gaf domain
THII_RS20560	COG2200	EAL domain
THII_RS20560	COG2199	diguanylate cyclase activity
THII_RS20565	COG5002	protein histidine kinase activity
THII_RS20565	COG5001	Diguanylate cyclase
THII_RS20590	COG5001	Diguanylate cyclase
THII_RS20590	COG4251	negative regulation of phosphorylation
THII_RS20590	COG2203	Gaf domain
THII_RS20590	COG3706	GGDEF domain
THII_RS20595	COG3437	response regulator, receiver
THII_RS20595	COG0784	Response regulator, receiver
THII_RS20630	COG0739	heme binding
THII_RS20640	COG0840	transmembrane signaling receptor activity
THII_RS20650	COG0840	transmembrane signaling receptor activity
THII_RS20660	COG2815	serine threonine protein kinase
THII_RS20660	COG0515	serine threonine protein kinase
THII_RS20700	COG2132	Multicopper oxidase
THII_RS20715	COG2207	Transcriptional regulator
THII_RS20730	COG3437	response regulator, receiver
THII_RS20735	COG0784	Response regulator, receiver
THII_RS20735	COG5002	protein histidine kinase activity
THII_RS20735	COG2198	Histidine kinase
THII_RS20780	COG2205	protein histidine kinase activity
THII_RS20780	COG0784	Response regulator, receiver
THII_RS20785	COG0840	transmembrane signaling receptor activity
THII_RS20790	COG0784	Response regulator, receiver
THII_RS20790	COG2205	protein histidine kinase activity
THII_RS20805	COG1196	nuclear chromosome segregation
THII_RS20805	COG0739	heme binding
THII_RS20805	COG0741	lytic transglycosylase activity
THII_RS20820	COG0628	permease
THII_RS20825	COG0745	RESPONSE REGULATOR receiver
THII_RS20825	COG2205	protein histidine kinase activity
THII_RS20825	COG3292	Two component regulator propeller
THII_RS20855	COG1404	Belongs to the peptidase S8 family
THII_RS20860	COG0784	Response regulator, receiver
THII_RS20860	COG3437	response regulator, receiver
THII_RS20875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THII_RS20875	COG2205	protein histidine kinase activity