locus-tag	class	description
J8380_RS00010	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
J8380_RS00025	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
J8380_RS00070	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J8380_RS00075	COG2885	chlorophyll binding
J8380_RS00090	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J8380_RS00095	COG3122	Protein conserved in bacteria
J8380_RS00125	COG0732	type I restriction modification DNA specificity domain
J8380_RS00135	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J8380_RS00145	COG0795	lipopolysaccharide-transporting ATPase activity
J8380_RS00155	COG2211	Major facilitator Superfamily
J8380_RS00160	COG0708	Exodeoxyribonuclease III
J8380_RS00165	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
J8380_RS00170	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J8380_RS00195	COG0367	asparagine synthase
J8380_RS00230	COG0617	tRNA 3'-terminal CCA addition
J8380_RS00235	COG0446	pyridine nucleotide-disulphide oxidoreductase
J8380_RS00260	COG3609	addiction module antidote protein, CC2985 family
J8380_RS00265	COG2319	Wd-40 repeat
J8380_RS00265	COG4249	Peptidase C14 caspase catalytic subunit p20
J8380_RS00275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J8380_RS00280	COG2270	Major facilitator Superfamily
J8380_RS00295	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
J8380_RS00300	COG0316	Belongs to the HesB IscA family
J8380_RS00315	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
J8380_RS00325	COG1981	membrane
J8380_RS00330	COG0494	nUDIX hydrolase
J8380_RS00340	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
J8380_RS00365	COG1404	Belongs to the peptidase S8 family
J8380_RS00385	COG0742	ribosomal rna small subunit methyltransferase
J8380_RS00390	COG0612	Peptidase, M16
J8380_RS00395	COG0612	Peptidase, M16
J8380_RS00400	COG0552	protein localization to endoplasmic reticulum
J8380_RS00405	COG2884	Cell division ATP-binding protein ftsE
J8380_RS00410	COG2177	Part of the ABC transporter FtsEX involved in
J8380_RS00420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J8380_RS00425	COG4174	ABC transporter (Permease)
J8380_RS00430	COG0747	negative chemotaxis
J8380_RS00460	COG1648	precorrin-2 dehydrogenase activity
J8380_RS00460	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
J8380_RS00470	COG1393	Belongs to the ArsC family
J8380_RS00475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J8380_RS00485	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
J8380_RS00490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J8380_RS00500	COG4657	Part of a membrane complex involved in electron transport
J8380_RS00505	COG2878	Part of a membrane complex involved in electron transport
J8380_RS00515	COG4658	electron transport chain
J8380_RS00520	COG4659	FMN binding
J8380_RS00525	COG4660	Part of a membrane complex involved in electron transport
J8380_RS00530	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
J8380_RS00575	COG0493	'glutamate synthase
J8380_RS00590	COG2920	part of a sulfur-relay system
J8380_RS00595	COG2168	tRNA wobble position uridine thiolation
J8380_RS00600	COG2923	Belongs to the DsrF TusC family
J8380_RS00605	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
J8380_RS00610	COG2221	Nitrite and sulphite reductase 4Fe-4S
J8380_RS00615	COG2221	Nitrite and sulphite reductase 4Fe-4S
J8380_RS00650	COG3128	pkhd-type hydroxylase
J8380_RS00665	COG0308	aminopeptidase N
J8380_RS00690	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
J8380_RS00695	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
J8380_RS00695	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
J8380_RS00700	COG2814	Major facilitator Superfamily
J8380_RS00720	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
J8380_RS00740	COG2205	protein histidine kinase activity
J8380_RS00740	COG0784	Response regulator, receiver
J8380_RS00745	COG0745	RESPONSE REGULATOR receiver
J8380_RS00900	COG4932	domain protein
J8380_RS00900	COG3266	domain, Protein
J8380_RS00900	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
J8380_RS00910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J8380_RS00920	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J8380_RS00925	COG5002	protein histidine kinase activity
J8380_RS00925	COG5001	Diguanylate cyclase
J8380_RS00930	COG0335	large ribosomal subunit rRNA binding
J8380_RS00935	COG0336	Belongs to the RNA methyltransferase TrmD family
J8380_RS00940	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
J8380_RS00945	COG0228	four-way junction DNA binding
J8380_RS00950	COG3738	Protein conserved in bacteria
J8380_RS00980	COG4137	Cytochrome C assembly protein
J8380_RS00985	COG4536	flavin adenine dinucleotide binding
J8380_RS00995	COG0513	Belongs to the DEAD box helicase family
J8380_RS01005	COG0494	nUDIX hydrolase
J8380_RS01010	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
J8380_RS01015	COG0653	protein targeting
J8380_RS01020	COG1196	nuclear chromosome segregation
J8380_RS01020	COG0741	lytic transglycosylase activity
J8380_RS01020	COG0739	heme binding
J8380_RS01030	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
J8380_RS01040	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
J8380_RS01055	COG1181	Belongs to the D-alanine--D-alanine ligase family
J8380_RS01060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J8380_RS01065	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
J8380_RS01070	COG0772	Belongs to the SEDS family
J8380_RS01075	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
J8380_RS01080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J8380_RS01085	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
J8380_RS01090	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
J8380_RS01105	COG0275	rRNA processing
J8380_RS01110	COG2001	Belongs to the MraZ family
J8380_RS01125	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
J8380_RS01135	COG1757	Na H antiporter
J8380_RS01150	COG0515	serine threonine protein kinase
J8380_RS01150	COG2815	serine threonine protein kinase
J8380_RS01155	COG0360	Binds together with S18 to 16S ribosomal RNA
J8380_RS01160	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
J8380_RS01170	COG0359	binds to the 23S rRNA
J8380_RS01175	COG0305	Participates in initiation and elongation during chromosome replication
J8380_RS01180	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
J8380_RS01190	COG2205	protein histidine kinase activity
J8380_RS01195	COG0745	RESPONSE REGULATOR receiver
J8380_RS01250	COG0720	synthase
J8380_RS01265	COG3250	beta-galactosidase activity
J8380_RS01275	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
J8380_RS01295	COG2208	phosphoserine phosphatase activity
J8380_RS01350	COG2863	cytochrome
J8380_RS01360	COG0446	pyridine nucleotide-disulphide oxidoreductase
J8380_RS01385	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
J8380_RS01390	COG0537	adenosine 5'-monophosphoramidase activity
J8380_RS01435	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
J8380_RS01465	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
J8380_RS01470	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J8380_RS01480	COG0579	oxidoreductase
J8380_RS01485	COG0363	glucosamine-6-phosphate deaminase activity
J8380_RS01490	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
J8380_RS01495	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
J8380_RS01510	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
J8380_RS01540	COG1088	dTDP-glucose 4,6-dehydratase activity
J8380_RS01545	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J8380_RS01600	COG0489	protein tyrosine kinase activity
J8380_RS01640	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
J8380_RS01655	COG1487	ribonuclease activity
J8380_RS01660	COG0232	Belongs to the dGTPase family. Type 2 subfamily
J8380_RS01665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J8380_RS01680	COG0019	diaminopimelate decarboxylase activity
J8380_RS01690	COG3876	Protein conserved in bacteria
J8380_RS01695	COG2226	methyltransferase
J8380_RS01700	COG0084	hydrolase, TatD family'
J8380_RS01705	COG2918	glutathione biosynthetic process
J8380_RS01710	COG0724	RNA recognition motif
J8380_RS01715	COG0762	integral membrane protein
J8380_RS01730	COG5297	Belongs to the glycosyl hydrolase family 6
J8380_RS01730	COG4733	cellulase activity
J8380_RS01735	COG4733	cellulase activity
J8380_RS01735	COG5297	Belongs to the glycosyl hydrolase family 6
J8380_RS01765	COG0004	ammonium transporteR
J8380_RS01775	COG0606	chelatase, subunit chli
J8380_RS01780	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
J8380_RS01800	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
J8380_RS01805	COG0848	biopolymer transport protein
J8380_RS01810	COG0811	peptide transport
J8380_RS01820	COG1294	oxidase, subunit
J8380_RS01825	COG4890	Cyd operon protein YbgT
J8380_RS01835	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
J8380_RS01885	COG1074	ATP-dependent DNA helicase activity
J8380_RS01930	COG1674	ftsk spoiiie
J8380_RS01950	COG0537	adenosine 5'-monophosphoramidase activity
J8380_RS01980	COG0537	adenosine 5'-monophosphoramidase activity
J8380_RS02000	COG0714	Associated with various cellular activities
J8380_RS02005	COG3028	Belongs to the UPF0307 family
J8380_RS02040	COG1131	(ABC) transporter
J8380_RS02050	COG1028	Short-chain dehydrogenase reductase Sdr
J8380_RS02060	COG1968	undecaprenyl-diphosphatase activity
J8380_RS02065	COG1444	tRNA N-acetyltransferase activity
J8380_RS02075	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
J8380_RS02075	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J8380_RS02090	COG0488	(ABC) transporter
J8380_RS02095	COG0745	RESPONSE REGULATOR receiver
J8380_RS02115	COG2022	thiamine diphosphate biosynthetic process
J8380_RS02165	COG1006	Multisubunit Na H antiporter MnhC subunit
J8380_RS02170	COG0651	ATP synthesis coupled electron transport
J8380_RS02175	COG0651	ATP synthesis coupled electron transport
J8380_RS02185	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J8380_RS02185	COG2111	Na H antiporter
J8380_RS02190	COG1301	dicarboxylic acid transport
J8380_RS02195	COG2239	Acts as a magnesium transporter
J8380_RS02200	COG0668	transmembrane transport
J8380_RS02205	COG1509	lysine 2,3-aminomutase activity
J8380_RS02210	COG0438	transferase activity, transferring glycosyl groups
J8380_RS02215	COG3100	YcgL domain-containing protein
J8380_RS02215	COG0561	phosphatase activity
J8380_RS02260	COG0741	lytic transglycosylase activity
J8380_RS02295	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
J8380_RS02305	COG1944	ATP diphosphatase activity
J8380_RS02310	COG3668	Plasmid stabilization system
J8380_RS02315	COG3609	addiction module antidote protein, CC2985 family
J8380_RS02335	COG0045	succinate-CoA ligase (ADP-forming) activity
J8380_RS02335	COG1042	CoA-binding domain protein
J8380_RS02335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
J8380_RS02340	COG0123	including yeast histone deacetylase and acetoin utilization protein
J8380_RS02355	COG0513	Belongs to the DEAD box helicase family
J8380_RS02375	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
J8380_RS02390	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
J8380_RS02400	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
J8380_RS02415	COG3956	TIGRFAM MazG family protein
J8380_RS02420	COG0632	four-way junction helicase activity
J8380_RS02430	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J8380_RS02440	COG0751	glycine-tRNA ligase activity
J8380_RS02500	COG0735	belongs to the Fur family
J8380_RS02505	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
J8380_RS02510	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
J8380_RS02520	COG0218	Necessary for normal cell division and for the maintenance of normal septation
J8380_RS02530	COG1333	cytochrome c biogenesis protein
J8380_RS02535	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J8380_RS02540	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J8380_RS02545	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
J8380_RS02550	COG0321	lipoyl(octanoyl) transferase activity
J8380_RS02575	COG2951	lytic endotransglycosylase activity
J8380_RS02625	COG0792	nuclease activity
J8380_RS02630	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
J8380_RS02645	COG2921	Belongs to the UPF0250 family
J8380_RS02650	COG1686	Belongs to the peptidase S11 family
J8380_RS02665	COG2951	lytic endotransglycosylase activity
J8380_RS02710	COG0792	nuclease activity
J8380_RS02715	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
J8380_RS02720	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
J8380_RS02720	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
J8380_RS02755	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
J8380_RS02760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J8380_RS02775	COG0586	Pfam SNARE associated Golgi protein
J8380_RS02780	COG0583	DNA-binding transcription factor activity
J8380_RS02785	COG1741	Belongs to the pirin family
J8380_RS02790	COG3038	cytochrome b561
J8380_RS02800	COG4191	Histidine kinase
J8380_RS02805	COG1162	GTPase activity
J8380_RS02815	COG0501	Belongs to the peptidase M48B family
J8380_RS02820	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
J8380_RS02825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J8380_RS02930	COG0488	(ABC) transporter
J8380_RS02935	COG0625	glutathione transferase activity
J8380_RS02940	COG0517	IMP dehydrogenase activity
J8380_RS02965	COG2204	response regulator
J8380_RS02970	COG0791	NLP P60 protein
J8380_RS02985	COG1477	protein flavinylation
J8380_RS03015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J8380_RS03040	COG2165	general secretion pathway protein
J8380_RS03050	COG1040	competence protein
J8380_RS03060	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
J8380_RS03065	COG4628	conserved protein (DUF2132)
J8380_RS03090	COG0154	amidase activity
J8380_RS03095	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J8380_RS03100	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J8380_RS03120	COG0596	Alpha beta hydrolase
J8380_RS03130	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
J8380_RS03135	COG1077	Cell shape determining protein MreB Mrl
J8380_RS03140	COG1792	Involved in formation and maintenance of cell shape
J8380_RS03150	COG1469	GTP cyclohydrolase I activity
J8380_RS03155	COG0330	HflC and HflK could
J8380_RS03160	COG1585	Membrane protein implicated in regulation of membrane protease activity
J8380_RS03165	COG0217	transcriptional regulatory protein
J8380_RS03170	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
J8380_RS03185	COG2983	Belongs to the UPF0260 family
J8380_RS03190	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
J8380_RS03200	COG3954	Phosphoribulokinase
J8380_RS03225	COG1487	ribonuclease activity
J8380_RS03255	COG0352	thiamine-phosphate diphosphorylase activity
J8380_RS03260	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J8380_RS03265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J8380_RS03275	COG1385	rRNA (uridine-N3-)-methyltransferase activity
J8380_RS03280	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
J8380_RS03285	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
J8380_RS03290	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
J8380_RS03295	COG0131	Imidazoleglycerol-phosphate dehydratase
J8380_RS03310	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
J8380_RS03325	COG2268	Band 7 protein
J8380_RS03330	COG0301	tRNA thio-modification
J8380_RS03335	COG1346	cytolysis
J8380_RS03345	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
J8380_RS03355	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
J8380_RS03360	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J8380_RS03370	COG4452	Inner membrane protein CreD
J8380_RS03375	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
J8380_RS03390	COG4680	protein conserved in bacteria
J8380_RS03395	COG5499	transcription regulator containing HTH domain
J8380_RS03400	COG0540	Belongs to the ATCase OTCase family
J8380_RS03405	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J8380_RS03410	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
J8380_RS03415	COG0196	riboflavin kinase activity
J8380_RS03420	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
J8380_RS03425	COG1595	DNA-templated transcription, initiation
J8380_RS03445	COG0408	coproporphyrinogen oxidase activity
J8380_RS03455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J8380_RS03490	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
J8380_RS03520	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
J8380_RS03530	COG2027	D-alanyl-D-alanine carboxypeptidase
J8380_RS03535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J8380_RS03540	COG0604	alcohol dehydrogenase
J8380_RS03575	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
J8380_RS03595	COG0596	Alpha beta hydrolase
J8380_RS03600	COG1490	D-aminoacyl-tRNA deacylase activity
J8380_RS03605	COG1331	Highly conserved protein containing a thioredoxin domain
J8380_RS03640	COG5007	Belongs to the BolA IbaG family
J8380_RS03645	COG1611	Belongs to the LOG family
J8380_RS03655	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
J8380_RS03660	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
J8380_RS03670	COG0174	glutamine synthetase
J8380_RS03700	COG3852	Histidine kinase
J8380_RS03710	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J8380_RS03775	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
J8380_RS03805	COG2198	Histidine kinase
J8380_RS03805	COG0784	Response regulator, receiver
J8380_RS03805	COG0643	Histidine kinase
J8380_RS03815	COG0840	transmembrane signaling receptor activity
J8380_RS03835	COG1408	metallophosphoesterase
J8380_RS03845	COG2210	Belongs to the sulfur carrier protein TusA family
J8380_RS03850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J8380_RS03865	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
J8380_RS03900	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
J8380_RS03900	COG0543	2 iron, 2 sulfur cluster binding
J8380_RS03915	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
J8380_RS03925	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
J8380_RS03935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J8380_RS03940	COG1561	YicC-like family, N-terminal region
J8380_RS03960	COG1690	Belongs to the RtcB family
J8380_RS03965	COG3001	Fructosamine kinase
J8380_RS03990	COG4650	regulator
J8380_RS04000	COG4953	penicillin-binding protein 1C
J8380_RS04005	COG0191	fructose-bisphosphate aldolase activity
J8380_RS04015	COG0126	phosphoglycerate kinase activity
J8380_RS04020	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
J8380_RS04025	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
J8380_RS04030	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
J8380_RS04045	COG3177	Filamentation induced by cAMP protein fic
J8380_RS04055	COG3541	Predicted nucleotidyltransferase
J8380_RS04090	COG0436	Aminotransferase
J8380_RS04140	COG5001	Diguanylate cyclase
J8380_RS04140	COG2203	Gaf domain
J8380_RS04140	COG3706	GGDEF domain
J8380_RS04140	COG4251	negative regulation of phosphorylation
J8380_RS04165	COG0860	N-Acetylmuramoyl-L-alanine amidase
J8380_RS04170	COG0802	atpase or kinase
J8380_RS04175	COG2996	Protein conserved in bacteria
J8380_RS04180	COG0805	protein transport
J8380_RS04185	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J8380_RS04190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J8380_RS04195	COG0140	phosphoribosyl-ATP diphosphatase activity
J8380_RS04200	COG0107	imidazoleglycerol-phosphate synthase activity
J8380_RS04205	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
J8380_RS04225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J8380_RS04230	COG0758	DNA mediated transformation
J8380_RS04235	COG2922	Belongs to the Smg family
J8380_RS04240	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
J8380_RS04260	COG3550	peptidyl-serine autophosphorylation
J8380_RS04275	COG2081	HI0933 family
J8380_RS04290	COG0500	methyltransferase
J8380_RS04295	COG0750	zinc metalloprotease
J8380_RS04315	COG1690	Belongs to the RtcB family
J8380_RS04325	COG0129	dihydroxy-acid dehydratase activity
J8380_RS04355	COG1166	arginine decarboxylase activity
J8380_RS04365	COG3100	YcgL domain-containing protein
J8380_RS04395	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J8380_RS04405	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
J8380_RS04410	COG0230	Belongs to the bacterial ribosomal protein bL34 family
J8380_RS04420	COG0706	membrane insertase activity
J8380_RS04430	COG0582	viral genome integration into host DNA
J8380_RS04510	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J8380_RS04530	COG1051	belongs to the nudix hydrolase family
J8380_RS04530	COG1056	cytidyltransferase-related domain
J8380_RS04540	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
J8380_RS04545	COG0826	peptidase U32
J8380_RS04555	COG4681	YaeQ
J8380_RS04570	COG3302	dmso reductase anchor subunit
J8380_RS04575	COG0437	4 iron, 4 sulfur cluster binding
J8380_RS04580	COG0243	molybdopterin cofactor binding
J8380_RS04585	COG0419	ATPase involved in DNA repair
J8380_RS04590	COG0420	3'-5' exonuclease activity
J8380_RS04600	COG2133	pyrroloquinoline quinone binding
J8380_RS04610	COG0488	(ABC) transporter
J8380_RS04625	COG0259	pyridoxamine-phosphate oxidase activity
J8380_RS04640	COG0084	hydrolase, TatD family'
J8380_RS04655	COG2885	chlorophyll binding
J8380_RS04670	COG0840	transmembrane signaling receptor activity
J8380_RS04715	COG3411	Ferredoxin
J8380_RS04720	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
J8380_RS04725	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J8380_RS04735	COG0254	rRNA binding
J8380_RS04740	COG4783	chaperone-mediated protein folding
J8380_RS04745	COG0281	malic enzyme
J8380_RS04760	COG1587	Uroporphyrinogen-III synthase
J8380_RS04765	COG0181	hydroxymethylbilane synthase activity
J8380_RS04770	COG4206	TonB-dependent receptor
J8380_RS04780	COG0784	Response regulator, receiver
J8380_RS04780	COG3437	response regulator, receiver
J8380_RS04825	COG2205	protein histidine kinase activity
J8380_RS04830	COG0745	RESPONSE REGULATOR receiver
J8380_RS04835	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
J8380_RS04840	COG0569	domain protein
J8380_RS04845	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
J8380_RS04850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J8380_RS04850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J8380_RS04860	COG2814	Major facilitator Superfamily
J8380_RS04865	COG0714	Associated with various cellular activities
J8380_RS04885	COG3550	peptidyl-serine autophosphorylation
J8380_RS04905	COG2304	oxidoreductase activity
J8380_RS04975	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
J8380_RS04985	COG0701	Predicted permease
J8380_RS05000	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J8380_RS05060	COG0583	DNA-binding transcription factor activity
J8380_RS05065	COG1136	(ABC) transporter
J8380_RS05065	COG0577	efflux transmembrane transporter activity
J8380_RS05085	COG1309	transcriptional regulator
J8380_RS05100	COG0659	secondary active sulfate transmembrane transporter activity
J8380_RS05150	COG4804	nuclease activity
J8380_RS05155	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
J8380_RS05165	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
J8380_RS05180	COG0425	Belongs to the sulfur carrier protein TusA family
J8380_RS05190	COG1309	transcriptional regulator
J8380_RS05205	COG3220	belongs to the UPF0276 family
J8380_RS05250	COG3220	belongs to the UPF0276 family
J8380_RS05260	COG2824	Alkylphosphonate utilization operon protein PhnA
J8380_RS05285	COG2204	response regulator
J8380_RS05325	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
J8380_RS05350	COG0515	serine threonine protein kinase
J8380_RS05350	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J8380_RS05365	COG4804	nuclease activity
J8380_RS05370	COG4249	Peptidase C14 caspase catalytic subunit p20
J8380_RS05370	COG2319	Wd-40 repeat
J8380_RS05385	COG2354	Protein conserved in bacteria
J8380_RS05390	COG0248	Ppx GppA phosphatase
J8380_RS05400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J8380_RS05405	COG1758	RNA polymerase activity
J8380_RS05425	COG1104	cysteine desulfurase activity
J8380_RS05430	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
J8380_RS05435	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J8380_RS05465	COG5002	protein histidine kinase activity
J8380_RS05470	COG0745	RESPONSE REGULATOR receiver
J8380_RS05475	COG5002	protein histidine kinase activity
J8380_RS05475	COG2176	DNA-directed DNA polymerase activity
J8380_RS05515	COG0116	Belongs to the methyltransferase superfamily
J8380_RS05515	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J8380_RS05525	COG0151	Belongs to the GarS family
J8380_RS05535	COG1047	Peptidyl-prolyl cis-trans
J8380_RS05540	COG0166	Belongs to the GPI family
J8380_RS05545	COG0837	glucose binding
J8380_RS05550	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
J8380_RS05570	COG0297	glycogen (starch) synthase activity
J8380_RS05575	COG0058	SHG alpha-glucan phosphorylase activity
J8380_RS05585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J8380_RS05590	COG2046	Belongs to the sulfate adenylyltransferase family
J8380_RS05605	COG0563	adenylate kinase activity
J8380_RS05610	COG1047	Peptidyl-prolyl cis-trans
J8380_RS05620	COG0205	6-phosphofructokinase activity
J8380_RS05630	COG0724	RNA recognition motif
J8380_RS05655	COG2048	Heterodisulfide reductase, subunit B
J8380_RS05685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J8380_RS05685	COG0723	plastoquinol--plastocyanin reductase activity
J8380_RS05720	COG0179	Fumarylacetoacetate (FAA) hydrolase
J8380_RS05725	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J8380_RS05740	COG4636	protein conserved in cyanobacteria
J8380_RS05745	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
J8380_RS05750	COG3550	peptidyl-serine autophosphorylation
J8380_RS05760	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
J8380_RS05770	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J8380_RS05780	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
J8380_RS05790	COG0585	pseudouridine synthase activity
J8380_RS05795	COG0156	8-amino-7-oxononanoate synthase activity
J8380_RS05800	COG0425	Belongs to the sulfur carrier protein TusA family
J8380_RS05805	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
J8380_RS05815	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
J8380_RS05845	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
J8380_RS05930	COG1652	LysM domain
J8380_RS05940	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
J8380_RS05955	COG5000	phosphorelay sensor kinase activity
J8380_RS05960	COG2204	response regulator
J8380_RS05965	COG0569	domain protein
J8380_RS05970	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
J8380_RS05980	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
J8380_RS05990	COG5265	(ABC) transporter
J8380_RS05995	COG4232	protein-disulfide reductase activity
J8380_RS06000	COG4232	protein-disulfide reductase activity
J8380_RS06025	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J8380_RS06030	COG1538	Outer membrane efflux protein
J8380_RS06040	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
J8380_RS06070	COG2943	transferase activity, transferring hexosyl groups
J8380_RS06080	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
J8380_RS06090	COG2226	methyltransferase
J8380_RS06115	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J8380_RS06135	COG0037	tRNA processing
J8380_RS06140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J8380_RS06200	COG4789	Type iii secretion
J8380_RS06210	COG4792	protein secretion
J8380_RS06215	COG4791	protein targeting
J8380_RS06220	COG4794	Type iii secretion
J8380_RS06225	COG4790	Type iii secretion
J8380_RS06270	COG4669	(LipO)protein
J8380_RS06275	COG1560	Kdo2-lipid A biosynthetic process
J8380_RS06280	COG1058	Belongs to the CinA family
J8380_RS06280	COG1546	Belongs to the CinA family
J8380_RS06285	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
J8380_RS06295	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
J8380_RS06300	COG1187	pseudouridine synthase activity
J8380_RS06315	COG0697	spore germination
J8380_RS06330	COG3609	addiction module antidote protein, CC2985 family
J8380_RS06355	COG2197	response regulator
J8380_RS06360	COG4585	Histidine kinase
J8380_RS06370	COG3738	Protein conserved in bacteria
J8380_RS06380	COG0418	dihydroorotase activity
J8380_RS06450	COG0277	FAD linked oxidase domain protein
J8380_RS06455	COG1620	l-lactate permease
J8380_RS06460	COG2186	Transcriptional regulator
J8380_RS06465	COG0247	lactate metabolic process
J8380_RS06470	COG1139	Iron-sulfur cluster binding protein
J8380_RS06485	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J8380_RS06490	COG1192	Involved in chromosome partitioning
J8380_RS06500	COG2205	protein histidine kinase activity
J8380_RS06500	COG3437	response regulator, receiver
J8380_RS06500	COG3850	Histidine kinase
J8380_RS06500	COG4999	Histidine kinase
J8380_RS06510	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
J8380_RS06535	COG1217	gtp-binding protein TYPA
J8380_RS06540	COG2813	Specifically methylates the guanine in position
J8380_RS06545	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
J8380_RS06560	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
J8380_RS06565	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
J8380_RS06575	COG3031	protein transport across the cell outer membrane
J8380_RS06585	COG3621	Patatin-like phospholipase
J8380_RS06620	COG3217	Mosc domain protein beta barrel domain protein
J8380_RS06620	COG0633	Ferredoxin
J8380_RS06635	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
J8380_RS06710	COG2255	four-way junction helicase activity
J8380_RS06715	COG0824	Thioesterase
J8380_RS06720	COG0811	peptide transport
J8380_RS06735	COG0823	Involved in the tonB-independent uptake of proteins
J8380_RS06740	COG2885	chlorophyll binding
J8380_RS06745	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
J8380_RS06750	COG0602	queuosine metabolic process
J8380_RS06790	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
J8380_RS06795	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J8380_RS06800	COG1671	Belongs to the UPF0178 family
J8380_RS06805	COG0519	Catalyzes the synthesis of GMP from XMP
J8380_RS06850	COG2738	Putative neutral zinc metallopeptidase
J8380_RS06860	COG1218	3'(2'),5'-bisphosphate nucleotidase
J8380_RS06880	COG1132	(ABC) transporter
J8380_RS06915	COG1643	Atp-dependent helicase
J8380_RS06920	COG4636	protein conserved in cyanobacteria
J8380_RS06940	COG0210	DNA helicase
J8380_RS06955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J8380_RS07020	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
J8380_RS07045	COG4181	ATPase activity
J8380_RS07055	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
J8380_RS07080	COG2184	nucleotidyltransferase activity
J8380_RS07100	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
J8380_RS07115	COG1196	nuclear chromosome segregation
J8380_RS07115	COG0739	heme binding
J8380_RS07115	COG0741	lytic transglycosylase activity
J8380_RS07125	COG0745	RESPONSE REGULATOR receiver
J8380_RS07165	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
J8380_RS07170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J8380_RS07180	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J8380_RS07190	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
J8380_RS07200	COG0517	IMP dehydrogenase activity
J8380_RS07200	COG0617	tRNA 3'-terminal CCA addition
J8380_RS07200	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
J8380_RS07210	COG2871	sodium ion transport
J8380_RS07215	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
J8380_RS07220	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
J8380_RS07230	COG1805	sodium ion transport
J8380_RS07285	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
J8380_RS07290	COG1121	(ABC) transporter
J8380_RS07295	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J8380_RS07300	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
J8380_RS07305	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
J8380_RS07315	COG1434	Gram-negative-bacterium-type cell wall biogenesis
J8380_RS07345	COG1720	tRNA m6t6A37 methyltransferase activity
J8380_RS07355	COG0729	surface antigen
J8380_RS07360	COG2911	Protein conserved in bacteria
J8380_RS07390	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
J8380_RS07405	COG0081	regulation of translation
J8380_RS07410	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
J8380_RS07415	COG0222	ribosome binding
J8380_RS07420	COG0085	RNA polymerase activity
J8380_RS07430	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
J8380_RS07435	COG0049	tRNA binding
J8380_RS07440	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
J8380_RS07450	COG0051	transcription antitermination factor activity, RNA binding
J8380_RS07455	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
J8380_RS07460	COG0088	Forms part of the polypeptide exit tunnel
J8380_RS07465	COG0089	rRNA binding
J8380_RS07470	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
J8380_RS07475	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
J8380_RS07480	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
J8380_RS07485	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
J8380_RS07490	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
J8380_RS07500	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
J8380_RS07505	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
J8380_RS07510	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
J8380_RS07515	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
J8380_RS07520	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
J8380_RS07525	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
J8380_RS07530	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
J8380_RS07535	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
J8380_RS07545	COG1841	ribosomal large subunit assembly
J8380_RS07550	COG0200	Binds to the 23S rRNA
J8380_RS07555	COG0201	protein transport
J8380_RS07560	COG0257	Belongs to the bacterial ribosomal protein bL36 family
J8380_RS07565	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
J8380_RS07570	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
J8380_RS07575	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
J8380_RS07580	COG0202	RNA polymerase activity
J8380_RS07585	COG0203	ribosomal protein L17
J8380_RS07595	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
J8380_RS07600	COG0445	tRNA wobble uridine modification
J8380_RS07605	COG0357	Ribosomal RNA small subunit methyltransferase G
J8380_RS07610	COG1192	Involved in chromosome partitioning
J8380_RS07615	COG1475	DNA binding
J8380_RS07620	COG0268	Binds directly to 16S ribosomal RNA
J8380_RS07625	COG0237	dephospho-CoA kinase activity
J8380_RS07630	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
J8380_RS07655	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
J8380_RS07660	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J8380_RS07665	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J8380_RS07670	COG0659	secondary active sulfate transmembrane transporter activity
J8380_RS07680	COG0315	cyclic pyranopterin monophosphate synthase activity
J8380_RS07685	COG0793	Belongs to the peptidase S41A family
J8380_RS07690	COG4942	peptidase
J8380_RS07700	COG1054	Belongs to the UPF0176 family
J8380_RS07710	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
J8380_RS07720	COG0189	ligase activity
J8380_RS07730	COG1765	OsmC-like protein
J8380_RS07735	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
J8380_RS07740	COG0791	NLP P60 protein
J8380_RS07755	COG1592	Rubrerythrin
J8380_RS07770	COG0142	geranyltranstransferase activity
J8380_RS07780	COG0211	Belongs to the bacterial ribosomal protein bL27 family
J8380_RS07790	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
J8380_RS07795	COG2967	ApaG domain
J8380_RS07855	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
J8380_RS07860	COG1923	regulation of RNA biosynthetic process
J8380_RS07865	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
J8380_RS07870	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
J8380_RS07875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J8380_RS07880	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
J8380_RS07890	COG0165	Argininosuccinate lyase
J8380_RS07895	COG3275	phosphorelay sensor kinase activity
J8380_RS07915	COG0356	it plays a direct role in the translocation of protons across the membrane
J8380_RS07920	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J8380_RS07925	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
J8380_RS07930	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J8380_RS07935	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
J8380_RS07940	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
J8380_RS07945	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
J8380_RS07950	COG0355	proton-transporting ATP synthase activity, rotational mechanism
J8380_RS07965	COG1162	GTPase activity
J8380_RS07975	COG0784	Response regulator, receiver
J8380_RS07975	COG2205	protein histidine kinase activity
J8380_RS07975	COG5002	protein histidine kinase activity
J8380_RS08005	COG1850	ribulose-bisphosphate carboxylase activity
J8380_RS08020	COG3002	Belongs to the UPF0753 family
J8380_RS08025	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J8380_RS08030	COG3002	Belongs to the UPF0753 family
J8380_RS08035	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J8380_RS08040	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J8380_RS08080	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
J8380_RS08085	COG0583	DNA-binding transcription factor activity
J8380_RS08115	COG0009	L-threonylcarbamoyladenylate synthase
J8380_RS08120	COG1850	ribulose-bisphosphate carboxylase activity
J8380_RS08150	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
J8380_RS08155	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
J8380_RS08220	COG1011	Hydrolase
J8380_RS08225	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J8380_RS08235	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
J8380_RS08240	COG1194	a g-specific adenine glycosylase
J8380_RS08255	COG2801	Transposase and inactivated derivatives
J8380_RS08275	COG0582	viral genome integration into host DNA
J8380_RS08285	COG3166	PFAM Fimbrial assembly family protein
J8380_RS08300	COG1450	Type ii and iii secretion system protein
J8380_RS08335	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J8380_RS08340	COG1215	transferase activity, transferring glycosyl groups
J8380_RS08355	COG1215	transferase activity, transferring glycosyl groups
J8380_RS08365	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
J8380_RS08370	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
J8380_RS08375	COG2894	cell division
J8380_RS08440	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J8380_RS08600	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J8380_RS08830	COG4974	Belongs to the 'phage' integrase family
J8380_RS08840	COG3243	poly(R)-hydroxyalkanoic acid synthase
J8380_RS08850	COG1115	amino acid carrier protein
J8380_RS08855	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
J8380_RS08875	COG1187	pseudouridine synthase activity
J8380_RS08930	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
J8380_RS08935	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
J8380_RS08940	COG2267	carboxylic ester hydrolase activity
J8380_RS08950	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
J8380_RS08980	COG0006	proline dipeptidase activity
J8380_RS08990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J8380_RS09000	COG0069	glutamate synthase activity
J8380_RS09010	COG4804	nuclease activity
J8380_RS09015	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
J8380_RS09040	COG4636	protein conserved in cyanobacteria
J8380_RS09090	COG0133	tryptophan synthase activity
J8380_RS09095	COG0159	tryptophan synthase activity
J8380_RS09105	COG0285	dihydrofolate synthase activity
J8380_RS09115	COG1286	toxin biosynthetic process
J8380_RS09125	COG1376	ErfK ybiS ycfS ynhG family protein
J8380_RS09135	COG2379	hydroxypyruvate reductase
J8380_RS09140	COG2833	Protein of unknown function (DUF455)
J8380_RS09150	COG0488	(ABC) transporter
J8380_RS09155	COG0739	heme binding
J8380_RS09185	COG1596	polysaccharide export
J8380_RS09190	COG4464	protein tyrosine phosphatase activity
J8380_RS09280	COG1083	cytidylyl-transferase
J8380_RS09285	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
J8380_RS09290	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
J8380_RS09295	COG2089	acid synthase
J8380_RS09305	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
J8380_RS09310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J8380_RS09340	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
J8380_RS09350	COG2801	Transposase and inactivated derivatives
J8380_RS09360	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
J8380_RS09405	COG0227	Belongs to the bacterial ribosomal protein bL28 family
J8380_RS09410	COG0267	Belongs to the bacterial ribosomal protein bL33 family
J8380_RS09420	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
J8380_RS09425	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
J8380_RS09445	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J8380_RS09450	COG1459	type II secretion system
J8380_RS09490	COG4636	protein conserved in cyanobacteria
J8380_RS09520	COG1337	RAMP superfamily
J8380_RS09525	COG1337	RAMP superfamily
J8380_RS09580	COG1518	maintenance of DNA repeat elements
J8380_RS09595	COG0405	Gamma-glutamyltransferase
J8380_RS09620	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
J8380_RS09625	COG1238	metal cluster binding
J8380_RS09640	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J8380_RS09660	COG2326	polyphosphate kinase activity
J8380_RS09665	COG1373	ATPase (AAA superfamily
J8380_RS09670	COG0583	DNA-binding transcription factor activity
J8380_RS09675	COG1250	3-hydroxyacyl-CoA dehydrogenase
J8380_RS09675	COG1024	Enoyl-CoA hydratase
J8380_RS09680	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
J8380_RS09700	COG3118	belongs to the thioredoxin family
J8380_RS09710	COG2194	sulfuric ester hydrolase activity
J8380_RS09720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J8380_RS09775	COG0546	phosphoglycolate phosphatase activity
J8380_RS09840	COG4181	ATPase activity
J8380_RS09845	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
J8380_RS09870	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J8380_RS09880	COG1373	ATPase (AAA superfamily
J8380_RS09890	COG4636	protein conserved in cyanobacteria
J8380_RS09905	COG0489	protein tyrosine kinase activity
J8380_RS09910	COG0842	Transport permease protein
J8380_RS09915	COG1131	(ABC) transporter
J8380_RS09920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J8380_RS09945	COG1534	Rna-binding protein
J8380_RS09950	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
J8380_RS09960	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
J8380_RS09970	COG0149	triose-phosphate isomerase activity
J8380_RS09975	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
J8380_RS09985	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J8380_RS09990	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J8380_RS09995	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J8380_RS10000	COG0649	NAD binding
J8380_RS10015	COG1034	ATP synthesis coupled electron transport
J8380_RS10020	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
J8380_RS10025	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J8380_RS10035	COG0713	ATP synthesis coupled electron transport
J8380_RS10050	COG1007	ATP synthesis coupled electron transport
J8380_RS10065	COG0779	Required for maturation of 30S ribosomal subunits
J8380_RS10070	COG0195	Participates in both transcription termination and antitermination
J8380_RS10070	COG2251	uridine kinase activity
J8380_RS10075	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
J8380_RS10080	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
J8380_RS10085	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
J8380_RS10105	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
J8380_RS10115	COG1053	succinate dehydrogenase
J8380_RS10125	COG2009	succinate dehydrogenase
J8380_RS10135	COG0567	Dehydrogenase, E1 component
J8380_RS10140	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
J8380_RS10165	COG0372	Belongs to the citrate synthase family
J8380_RS10190	COG0215	cysteine-tRNA ligase activity
J8380_RS10215	COG4636	protein conserved in cyanobacteria
J8380_RS10235	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
J8380_RS10280	COG0438	transferase activity, transferring glycosyl groups
J8380_RS10335	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
J8380_RS10340	COG2226	methyltransferase
J8380_RS10355	COG3550	peptidyl-serine autophosphorylation
J8380_RS10370	COG0573	inorganic phosphate transmembrane transporter activity
J8380_RS10380	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
J8380_RS10400	COG0784	Response regulator, receiver
J8380_RS10400	COG5002	protein histidine kinase activity
J8380_RS10400	COG2205	protein histidine kinase activity
J8380_RS10410	COG0436	Aminotransferase
J8380_RS10415	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
J8380_RS10425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J8380_RS10430	COG2350	Protein conserved in bacteria
J8380_RS10435	COG0009	L-threonylcarbamoyladenylate synthase
J8380_RS10440	COG1994	Peptidase M50
J8380_RS10445	COG0180	Tryptophanyl-tRNA synthetase
J8380_RS10450	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
J8380_RS10520	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
J8380_RS10530	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
J8380_RS10535	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
J8380_RS10545	COG0583	DNA-binding transcription factor activity
J8380_RS10550	COG0438	transferase activity, transferring glycosyl groups
J8380_RS10605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J8380_RS10615	COG1183	phosphatidylcholine synthase activity
J8380_RS10625	COG4591	ABC-type transport system involved in lipoprotein release permease component
J8380_RS10630	COG4591	ABC-type transport system involved in lipoprotein release permease component
J8380_RS10635	COG1136	(ABC) transporter
J8380_RS10660	COG2081	HI0933 family
J8380_RS10665	COG3132	Protein of unknown function, DUF480
J8380_RS10675	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
J8380_RS10700	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
J8380_RS10705	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
J8380_RS10710	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
J8380_RS10720	COG0330	HflC and HflK could
J8380_RS10725	COG0330	HflC and HflK could
J8380_RS10730	COG0739	heme binding
J8380_RS10735	COG0436	Aminotransferase
J8380_RS10740	COG0322	excinuclease ABC activity
J8380_RS10760	COG0261	This protein binds to 23S rRNA in the presence of protein L20
J8380_RS10760	COG3743	rRNA binding
J8380_RS10765	COG2885	chlorophyll binding
J8380_RS10770	COG0303	'Molybdopterin
J8380_RS10775	COG1404	Belongs to the peptidase S8 family
J8380_RS10780	COG2111	Na H antiporter
J8380_RS10780	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J8380_RS10790	COG0651	ATP synthesis coupled electron transport
J8380_RS10795	COG1863	multisubunit Na H antiporter MnhE subunit
J8380_RS10800	COG2212	antiporter activity
J8380_RS10805	COG1320	monovalent cation:proton antiporter activity
J8380_RS10835	COG3012	SEC-C Motif Domain Protein
J8380_RS10840	COG3012	SEC-C Motif Domain Protein
J8380_RS10855	COG2852	Protein conserved in bacteria
J8380_RS10895	COG2264	protein methyltransferase activity
J8380_RS10900	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
J8380_RS10905	COG0492	ferredoxin-NADP+ reductase activity
J8380_RS10910	COG1674	ftsk spoiiie
J8380_RS10915	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
J8380_RS10920	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
J8380_RS10925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J8380_RS10930	COG0508	dehydrogenase complex catalyzes the overall conversion of
J8380_RS10940	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J8380_RS10945	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
J8380_RS10950	COG1177	transmembrane transport
J8380_RS10955	COG1176	ABC-type spermidine putrescine transport system, permease component I
J8380_RS10960	COG3842	ATPase activity
J8380_RS11000	COG1715	Restriction endonuclease
J8380_RS11010	COG0542	response to heat
J8380_RS11110	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
J8380_RS11115	COG1047	Peptidyl-prolyl cis-trans
J8380_RS11120	COG1560	Kdo2-lipid A biosynthetic process
J8380_RS11125	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
J8380_RS11125	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
J8380_RS11135	COG0667	Aldo Keto reductase
J8380_RS11155	COG0859	PFAM glycosyl transferase family 9
J8380_RS11170	COG0463	Glycosyl transferase, family 2
J8380_RS11175	COG0859	PFAM glycosyl transferase family 9
J8380_RS11180	COG1519	Transferase
J8380_RS11215	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
J8380_RS11220	COG1127	ABC transporter
J8380_RS11270	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J8380_RS11275	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
J8380_RS11280	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
J8380_RS11310	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
J8380_RS11320	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
J8380_RS11345	COG3850	Histidine kinase
J8380_RS11345	COG0642	Histidine kinase
J8380_RS11350	COG0745	RESPONSE REGULATOR receiver
J8380_RS11355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J8380_RS11365	COG1309	transcriptional regulator
J8380_RS11370	COG0504	CTP synthase activity
J8380_RS11375	COG2877	3-deoxy-8-phosphooctulonate synthase activity
J8380_RS11380	COG0148	phosphopyruvate hydratase activity
J8380_RS11385	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
J8380_RS11390	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
J8380_RS11395	COG1393	Belongs to the ArsC family
J8380_RS11410	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
J8380_RS11420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J8380_RS11425	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
J8380_RS11445	COG2264	protein methyltransferase activity
J8380_RS11450	COG0439	Biotin carboxylase
J8380_RS11455	COG0511	ligase activity, forming carbon-carbon bonds
J8380_RS11460	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
J8380_RS11465	COG0433	COG0433 Predicted ATPase
J8380_RS11490	COG0537	adenosine 5'-monophosphoramidase activity
J8380_RS11500	COG1702	phosphate starvation-inducible protein PhoH
J8380_RS11505	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
J8380_RS11510	COG4535	Mg2 and Co2 transporter CorC
J8380_RS11515	COG0815	Transfers the fatty acyl group on membrane lipoproteins
J8380_RS11530	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
J8380_RS11535	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J8380_RS11570	COG0495	leucyl-tRNA aminoacylation
J8380_RS11585	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
J8380_RS11620	COG0746	molybdenum cofactor guanylyltransferase activity
J8380_RS11635	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J8380_RS11645	COG4797	methyltransferase
J8380_RS11645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
J8380_RS11655	COG0167	dihydroorotate dehydrogenase activity
J8380_RS11665	COG1472	Belongs to the glycosyl hydrolase 3 family
J8380_RS11680	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
J8380_RS11685	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
J8380_RS11700	COG1074	ATP-dependent DNA helicase activity
J8380_RS11720	COG2010	Cytochrome c
J8380_RS11800	COG3547	Transposase (IS116 IS110 IS902 family)
J8380_RS11830	COG3547	Transposase (IS116 IS110 IS902 family)
J8380_RS12000	COG1569	PIN domain
J8380_RS12005	COG3311	Transcriptional regulator
J8380_RS12045	COG0067	glutamate synthase
J8380_RS12045	COG0069	glutamate synthase activity
J8380_RS12045	COG0070	glutamate synthase
J8380_RS12050	COG0493	'glutamate synthase
J8380_RS12125	COG0505	Belongs to the CarA family
J8380_RS12130	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
J8380_RS12135	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J8380_RS12145	COG0033	Phosphoglucomutase
J8380_RS12160	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
J8380_RS12175	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
J8380_RS12185	COG0756	dUTP diphosphatase activity
J8380_RS12190	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
J8380_RS12195	COG2003	Belongs to the UPF0758 family
J8380_RS12200	COG0277	FAD linked oxidase domain protein
J8380_RS12215	COG1196	nuclear chromosome segregation
J8380_RS12220	COG3115	cell septum assembly
J8380_RS12225	COG3842	ATPase activity
J8380_RS12230	COG1178	ABC-type Fe3 transport system permease component
J8380_RS12235	COG1840	ABC-type Fe3 transport system, periplasmic component
J8380_RS12240	COG1555	photosystem II stabilization
J8380_RS12250	COG0754	glutathionylspermidine amidase activity
J8380_RS12265	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
J8380_RS12275	COG0028	Belongs to the TPP enzyme family
J8380_RS12295	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
J8380_RS12300	COG2900	Belongs to the SlyX family
J8380_RS12305	COG0137	argininosuccinate synthase activity
J8380_RS12325	COG3259	Nickel-dependent hydrogenase
J8380_RS12330	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
J8380_RS12335	COG3383	formate dehydrogenase (NAD+) activity
J8380_RS12340	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
J8380_RS12345	COG3954	Phosphoribulokinase
J8380_RS12370	COG0688	phosphatidylethanolamine metabolic process
J8380_RS12375	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
J8380_RS12410	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
J8380_RS12415	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
J8380_RS12420	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J8380_RS12420	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J8380_RS12435	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
J8380_RS12445	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
J8380_RS12450	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
J8380_RS12460	COG0564	pseudouridine synthase activity
J8380_RS12465	COG0812	UDP-N-acetylmuramate dehydrogenase activity
J8380_RS12470	COG2133	pyrroloquinoline quinone binding
J8380_RS12470	COG5183	chlorophyll binding
J8380_RS12480	COG0446	pyridine nucleotide-disulphide oxidoreductase
J8380_RS12495	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
J8380_RS12545	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
J8380_RS12555	COG3459	Glycosyltransferase 36 associated
J8380_RS12570	COG3237	CsbD-like
J8380_RS12590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J8380_RS12600	COG1136	(ABC) transporter
J8380_RS12610	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
J8380_RS12615	COG0789	Transcriptional regulator
J8380_RS12630	COG1752	Esterase of the alpha-beta hydrolase superfamily
J8380_RS12635	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
J8380_RS12640	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
J8380_RS12645	COG4115	mRNA cleavage
J8380_RS12665	COG0280	phosphate acetyltransferase
J8380_RS12665	COG0857	belongs to the CobB CobQ family
J8380_RS12670	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
J8380_RS12685	COG0500	methyltransferase
J8380_RS12715	COG1132	(ABC) transporter
J8380_RS12765	COG1518	maintenance of DNA repeat elements
J8380_RS12770	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
J8380_RS12780	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
J8380_RS12790	COG3040	lipid binding
J8380_RS12800	COG2202	Pas domain
J8380_RS12800	COG1366	Belongs to the anti-sigma-factor antagonist family
J8380_RS12805	COG4221	oxidoreductase activity
J8380_RS12840	COG0419	ATPase involved in DNA repair
J8380_RS12875	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
J8380_RS12895	COG1858	cytochrome C peroxidase
J8380_RS12905	COG3008	intermembrane lipid transfer
J8380_RS12910	COG2226	methyltransferase
J8380_RS12915	COG3012	SEC-C Motif Domain Protein
J8380_RS12925	COG0404	The glycine cleavage system catalyzes the degradation of glycine
J8380_RS12930	COG0509	glycine decarboxylation via glycine cleavage system
J8380_RS12935	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J8380_RS12935	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J8380_RS12980	COG1047	Peptidyl-prolyl cis-trans
J8380_RS12995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J8380_RS13000	COG0489	protein tyrosine kinase activity
J8380_RS13020	COG0717	Belongs to the dCTP deaminase family
J8380_RS13040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J8380_RS13050	COG1199	ATP-dependent helicase activity
J8380_RS13055	COG1214	PFAM Peptidase M22, glycoprotease
J8380_RS13060	COG1509	lysine 2,3-aminomutase activity
J8380_RS13065	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
J8380_RS13070	COG2363	Small membrane protein
J8380_RS13075	COG0742	ribosomal rna small subunit methyltransferase
J8380_RS13080	COG0271	Belongs to the BolA IbaG family
J8380_RS13085	COG0714	Associated with various cellular activities
J8380_RS13105	COG2304	oxidoreductase activity
J8380_RS13115	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
J8380_RS13120	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
J8380_RS13130	COG0776	regulation of translation
J8380_RS13135	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
J8380_RS13140	COG0284	orotidine-5'-phosphate decarboxylase activity
J8380_RS13145	COG2915	High frequency lysogenization protein hflD homolog
J8380_RS13160	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
J8380_RS13165	COG0542	response to heat
J8380_RS13170	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
J8380_RS13175	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
J8380_RS13190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J8380_RS13195	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
J8380_RS13205	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
J8380_RS13210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
J8380_RS13245	COG0300	oxidoreductase activity
J8380_RS13260	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
J8380_RS13270	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J8380_RS13270	COG0116	Belongs to the methyltransferase superfamily
J8380_RS13280	COG3318	Belongs to the UPF0149 family
J8380_RS13280	COG3012	SEC-C Motif Domain Protein
J8380_RS13290	COG2084	Dehydrogenase
J8380_RS13295	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
J8380_RS13320	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
J8380_RS13325	COG0745	RESPONSE REGULATOR receiver
J8380_RS13330	COG0438	transferase activity, transferring glycosyl groups
J8380_RS13345	COG0513	Belongs to the DEAD box helicase family
J8380_RS13350	COG2954	triphosphatase activity
J8380_RS13355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J8380_RS13360	COG0416	fatty acid biosynthetic process
J8380_RS13365	COG0333	Belongs to the bacterial ribosomal protein bL32 family
J8380_RS13375	COG0424	maF-like protein
J8380_RS13390	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
J8380_RS13405	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
J8380_RS13430	COG0587	DNA-directed DNA polymerase activity
J8380_RS13450	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J8380_RS13470	COG0037	tRNA processing
J8380_RS13475	COG0825	malonyl-CoA metabolic process
J8380_RS13480	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
J8380_RS13485	COG3118	belongs to the thioredoxin family
J8380_RS13495	COG1605	Chorismate mutase
J8380_RS13495	COG0077	Prephenate dehydratase
J8380_RS13500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J8380_RS13505	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
J8380_RS13520	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
J8380_RS13540	COG1858	cytochrome C peroxidase
J8380_RS13545	COG1858	cytochrome C peroxidase
J8380_RS13550	COG1858	cytochrome C peroxidase
J8380_RS13555	COG2193	ferroxidase activity
J8380_RS13650	COG0583	DNA-binding transcription factor activity
J8380_RS13740	COG3853	Toxic anion resistance protein (TelA)
J8380_RS13765	COG0791	NLP P60 protein
J8380_RS13770	COG1652	LysM domain
J8380_RS13795	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
J8380_RS13810	COG2308	Evidence 4 Homologs of previously reported genes of
J8380_RS13820	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J8380_RS13825	COG0012	GTP binding
J8380_RS13830	COG0193	aminoacyl-tRNA hydrolase activity
J8380_RS13835	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
J8380_RS13855	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
J8380_RS13860	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
J8380_RS13870	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
J8380_RS13875	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
J8380_RS13880	COG2890	protein-(glutamine-N5) methyltransferase activity
J8380_RS13915	COG0521	Mo-molybdopterin cofactor biosynthetic process
J8380_RS13920	COG0501	Belongs to the peptidase M48B family
J8380_RS13935	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
J8380_RS13940	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
J8380_RS13945	COG3123	guanosine phosphorylase activity
J8380_RS13950	COG0312	modulator of DNA gyrase
J8380_RS13955	COG0312	modulator of DNA gyrase
J8380_RS13980	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
J8380_RS13990	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
J8380_RS14000	COG1473	amidohydrolase
J8380_RS14020	COG0444	Belongs to the ABC transporter superfamily
J8380_RS14025	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
J8380_RS14030	COG0402	S-adenosylhomocysteine deaminase activity
J8380_RS14035	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J8380_RS14050	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J8380_RS14055	COG2226	methyltransferase
J8380_RS14060	COG1028	Short-chain dehydrogenase reductase Sdr
J8380_RS14065	COG0326	Molecular chaperone. Has ATPase activity
J8380_RS14110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J8380_RS14135	COG1358	cellular component organization or biogenesis
J8380_RS14155	COG0646	methionine synthase
J8380_RS14155	COG1410	methionine synthase
J8380_RS14180	COG0776	regulation of translation
J8380_RS14185	COG0072	phenylalanine-tRNA ligase activity
J8380_RS14185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J8380_RS14190	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
J8380_RS14195	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
J8380_RS14200	COG0291	Belongs to the bacterial ribosomal protein bL35 family
J8380_RS14210	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
J8380_RS14255	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
J8380_RS14260	COG0277	FAD linked oxidase domain protein
J8380_RS14265	COG0277	FAD linked oxidase domain protein
J8380_RS14270	COG0247	lactate metabolic process
J8380_RS14275	COG0343	queuine tRNA-ribosyltransferase activity
J8380_RS14285	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J8380_RS14310	COG3243	poly(R)-hydroxyalkanoic acid synthase
J8380_RS14320	COG0183	Belongs to the thiolase family
J8380_RS14325	COG1028	Short-chain dehydrogenase reductase Sdr
J8380_RS14330	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
J8380_RS14335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J8380_RS14355	COG0105	UTP biosynthetic process
J8380_RS14360	COG0820	rRNA (adenine-C2-)-methyltransferase activity
J8380_RS14375	COG0124	histidyl-tRNA synthetase
J8380_RS14385	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J8380_RS14400	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
J8380_RS14405	COG0134	indole-3-glycerol-phosphate synthase activity
J8380_RS14410	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
J8380_RS14415	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
J8380_RS14420	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
J8380_RS14445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J8380_RS14455	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
J8380_RS14465	COG0456	acetyltransferase
J8380_RS14470	COG1573	uracil-dna glycosylase
J8380_RS14475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J8380_RS14480	COG4608	Belongs to the ABC transporter superfamily
J8380_RS14560	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J8380_RS14560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J8380_RS14575	COG0556	nucleotide-excision repair
J8380_RS14595	COG2217	Heavy metal translocating P-type atpase
J8380_RS14605	COG0348	domain, Protein
J8380_RS14610	COG2010	Cytochrome c
J8380_RS14625	COG3278	Belongs to the heme-copper respiratory oxidase family
J8380_RS14630	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
J8380_RS14660	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
J8380_RS14665	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
J8380_RS14670	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
J8380_RS14675	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
J8380_RS14700	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
J8380_RS14750	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
J8380_RS14765	COG2319	Wd-40 repeat
J8380_RS14765	COG4249	Peptidase C14 caspase catalytic subunit p20
J8380_RS14775	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
J8380_RS14785	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
J8380_RS14785	COG4651	solute:proton antiporter activity
J8380_RS14790	COG0589	response to stress
J8380_RS14805	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J8380_RS14810	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J8380_RS14815	COG1862	Preprotein translocase
J8380_RS14820	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
J8380_RS14825	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
J8380_RS14840	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
J8380_RS14845	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J8380_RS14855	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
J8380_RS14860	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
J8380_RS14885	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J8380_RS14915	COG0582	viral genome integration into host DNA
J8380_RS14925	COG2801	Transposase and inactivated derivatives
J8380_RS14930	COG0442	prolyl-tRNA aminoacylation
J8380_RS14935	COG0138	bifunctional purine biosynthesis protein purh
J8380_RS14950	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J8380_RS14960	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J8380_RS14980	COG0515	serine threonine protein kinase
J8380_RS14980	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J8380_RS14995	COG0243	molybdopterin cofactor binding
J8380_RS15020	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
J8380_RS15025	COG0450	alkyl hydroperoxide reductase
J8380_RS15040	COG0723	plastoquinol--plastocyanin reductase activity
J8380_RS15060	COG0446	pyridine nucleotide-disulphide oxidoreductase
J8380_RS15070	COG2814	Major facilitator Superfamily
J8380_RS15095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J8380_RS15105	COG2814	Major facilitator Superfamily
J8380_RS15110	COG3272	Protein of unknown function (DUF1722)
J8380_RS15115	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
J8380_RS15115	COG3264	Mechanosensitive ion channel
J8380_RS15155	COG2957	Belongs to the agmatine deiminase family
J8380_RS15160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J8380_RS15165	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J8380_RS15165	COG0519	Catalyzes the synthesis of GMP from XMP
J8380_RS15180	COG1570	exodeoxyribonuclease VII activity
J8380_RS15200	COG0513	Belongs to the DEAD box helicase family
J8380_RS15205	COG0386	Belongs to the glutathione peroxidase family
J8380_RS15220	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
J8380_RS15225	COG3609	addiction module antidote protein, CC2985 family
J8380_RS15230	COG3668	Plasmid stabilization system
J8380_RS15235	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J8380_RS15255	COG1196	nuclear chromosome segregation
J8380_RS15310	COG0736	holo-[acyl-carrier-protein] synthase activity
J8380_RS15315	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
J8380_RS15325	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
J8380_RS15345	COG0481	GTPase activity
J8380_RS15355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J8380_RS15380	COG2801	Transposase and inactivated derivatives
J8380_RS15405	COG1468	defense response to virus
J8380_RS15405	COG1518	maintenance of DNA repeat elements
J8380_RS15445	COG0561	phosphatase activity
J8380_RS15450	COG3344	reverse transcriptase
J8380_RS15455	COG1518	maintenance of DNA repeat elements
J8380_RS15460	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
J8380_RS15540	COG2183	response to ionizing radiation
J8380_RS15570	COG0018	arginyl-trna synthetase
J8380_RS15600	COG0018	arginyl-trna synthetase
J8380_RS15620	COG1193	negative regulation of DNA recombination
J8380_RS15625	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
J8380_RS15630	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
J8380_RS15635	COG1388	LysM domain
J8380_RS15635	COG4942	peptidase
J8380_RS15675	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
J8380_RS15715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J8380_RS15720	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
J8380_RS15725	COG0142	geranyltranstransferase activity
J8380_RS15730	COG1722	exodeoxyribonuclease VII activity
J8380_RS15740	COG0557	exoribonuclease II activity
J8380_RS15745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J8380_RS15760	COG1322	Protein conserved in bacteria
J8380_RS15770	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
J8380_RS15775	COG2894	cell division
J8380_RS15790	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
J8380_RS15800	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J8380_RS15800	COG0519	Catalyzes the synthesis of GMP from XMP
J8380_RS15805	COG2258	MOSC domain
J8380_RS15820	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J8380_RS15830	COG0531	amino acid
J8380_RS15835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J8380_RS15840	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
J8380_RS15930	COG2944	sequence-specific DNA binding
J8380_RS15950	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
J8380_RS15960	COG5002	protein histidine kinase activity
J8380_RS15960	COG5001	Diguanylate cyclase
J8380_RS15970	COG4232	protein-disulfide reductase activity
J8380_RS15985	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
J8380_RS15990	COG0628	permease
J8380_RS16000	COG2885	chlorophyll binding
J8380_RS16050	COG2321	neutral zinc metallopeptidase
J8380_RS16055	COG0778	Nitroreductase
J8380_RS16075	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
J8380_RS16080	COG1663	tetraacyldisaccharide 4'-kinase activity
J8380_RS16080	COG2835	tetraacyldisaccharide 4'-kinase activity
J8380_RS16085	COG1663	tetraacyldisaccharide 4'-kinase activity
J8380_RS16095	COG0848	biopolymer transport protein
J8380_RS16100	COG0811	peptide transport
J8380_RS16110	COG0741	lytic transglycosylase activity
J8380_RS16115	COG2171	N-acyltransferase activity
J8380_RS16120	COG0436	Aminotransferase
J8380_RS16140	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
J8380_RS16140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J8380_RS16155	COG0287	Prephenate dehydrogenase
J8380_RS16160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J8380_RS16165	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
J8380_RS16170	COG0052	Belongs to the universal ribosomal protein uS2 family
J8380_RS16175	COG0024	Methionine aminopeptidase
J8380_RS16180	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
J8380_RS16185	COG1185	polyribonucleotide nucleotidyltransferase activity
J8380_RS16190	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
J8380_RS16195	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J8380_RS16230	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J8380_RS16270	COG2391	methyltransferase activity
J8380_RS16280	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
J8380_RS16285	COG0484	heat shock protein binding
J8380_RS16290	COG0443	Heat shock 70 kDa protein
J8380_RS16295	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
J8380_RS16310	COG0517	IMP dehydrogenase activity
J8380_RS16310	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
J8380_RS16315	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
J8380_RS16330	COG1137	ATPase activity
J8380_RS16345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J8380_RS16350	COG1660	Displays ATPase and GTPase activities
J8380_RS16355	COG0598	Magnesium transport protein CorA
J8380_RS16360	COG2951	lytic endotransglycosylase activity
J8380_RS16375	COG2719	SpoVR family
J8380_RS16380	COG2718	Belongs to the UPF0229 family
J8380_RS16385	COG2766	serine protein kinase
J8380_RS16395	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J8380_RS16405	COG2969	positive regulation of protein catabolic process
J8380_RS16410	COG0625	glutathione transferase activity
J8380_RS16415	COG2857	Cytochrome c1
J8380_RS16420	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
J8380_RS16425	COG0723	plastoquinol--plastocyanin reductase activity
J8380_RS16435	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J8380_RS16450	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
J8380_RS16465	COG2951	lytic endotransglycosylase activity
J8380_RS16470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J8380_RS16480	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
J8380_RS16485	COG2850	peptidyl-arginine hydroxylation
J8380_RS16510	COG2373	Large extracellular alpha-helical protein
J8380_RS16530	COG0517	IMP dehydrogenase activity
J8380_RS16530	COG0516	GMP reductase activity
J8380_RS16535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J8380_RS16540	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
J8380_RS16550	COG0789	Transcriptional regulator
J8380_RS16555	COG0415	Belongs to the DNA photolyase family
J8380_RS16560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J8380_RS16560	COG3153	acetyltransferase
J8380_RS16575	COG0676	glucose-6-phosphate 1-epimerase activity
J8380_RS16600	COG0714	Associated with various cellular activities
J8380_RS16615	COG1970	mechanosensitive ion channel activity
J8380_RS16620	COG4452	Inner membrane protein CreD
J8380_RS16625	COG0513	Belongs to the DEAD box helicase family
J8380_RS16645	COG4166	transmembrane transport
J8380_RS16650	COG0601	transmembrane transport
J8380_RS16655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J8380_RS16660	COG0525	valine-tRNA ligase activity
J8380_RS16695	COG0523	cobalamin synthesis protein
J8380_RS16710	COG1959	2 iron, 2 sulfur cluster binding
J8380_RS16710	COG1295	ribonuclease BN
J8380_RS16730	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J8380_RS16750	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
J8380_RS16760	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
J8380_RS16765	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
J8380_RS16770	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
J8380_RS16775	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
J8380_RS16810	COG2974	May be involved in recombination
J8380_RS16830	COG1959	2 iron, 2 sulfur cluster binding
J8380_RS16855	COG0179	Fumarylacetoacetate (FAA) hydrolase
J8380_RS16860	COG0583	DNA-binding transcription factor activity
J8380_RS16920	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
J8380_RS16930	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
J8380_RS16935	COG2137	regulation of response to DNA damage stimulus
J8380_RS16955	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
J8380_RS16960	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
J8380_RS16965	COG3243	poly(R)-hydroxyalkanoic acid synthase
J8380_RS16980	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
J8380_RS16980	COG0616	signal peptide processing
J8380_RS16985	COG0546	phosphoglycolate phosphatase activity
J8380_RS16995	COG1530	ribonuclease E activity
J8380_RS17000	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J8380_RS17005	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
J8380_RS17025	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J8380_RS17030	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J8380_RS17035	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J8380_RS17040	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J8380_RS17050	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J8380_RS17055	COG0750	zinc metalloprotease
J8380_RS17060	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
J8380_RS17065	COG0575	Belongs to the CDS family
J8380_RS17070	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
J8380_RS17075	COG0233	cytoplasmic translational termination
J8380_RS17080	COG0528	UMP kinase activity
J8380_RS17085	COG3150	esterase
J8380_RS17090	COG1420	regulation of RNA biosynthetic process
J8380_RS17095	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
J8380_RS17100	COG0497	DNA recombination
J8380_RS17115	COG2197	response regulator
J8380_RS17120	COG3850	Histidine kinase
J8380_RS17130	COG1797	cobyrinic acid a,c-diamide synthase activity
J8380_RS17160	COG3041	Addiction module toxin RelE StbE family
J8380_RS17165	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
J8380_RS17170	COG1210	Utp--glucose-1-phosphate uridylyltransferase
J8380_RS17200	COG1160	GTP binding
J8380_RS17205	COG0730	response to heat
J8380_RS17215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J8380_RS17250	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
J8380_RS17255	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
J8380_RS17295	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
J8380_RS17305	COG0828	Belongs to the bacterial ribosomal protein bS21 family
J8380_RS17310	COG0735	belongs to the Fur family
J8380_RS17315	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J8380_RS17325	COG2914	Belongs to the UPF0125 (RnfH) family
J8380_RS17330	COG2867	negative regulation of translational initiation
J8380_RS17350	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
J8380_RS17360	COG0066	3-isopropylmalate dehydratase activity
J8380_RS17365	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
J8380_RS17425	COG2319	Wd-40 repeat
J8380_RS17425	COG4249	Peptidase C14 caspase catalytic subunit p20
J8380_RS17440	COG0328	RNA-DNA hybrid ribonuclease activity
J8380_RS17450	COG1388	LysM domain
J8380_RS17450	COG0741	lytic transglycosylase activity
J8380_RS17460	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
J8380_RS17475	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
J8380_RS17495	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J8380_RS17500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J8380_RS17520	COG0776	regulation of translation
J8380_RS17525	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
J8380_RS17530	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
J8380_RS17535	COG0740	serine-type endopeptidase activity
J8380_RS17565	COG0745	RESPONSE REGULATOR receiver
J8380_RS17585	COG0840	transmembrane signaling receptor activity
J8380_RS17590	COG0643	Histidine kinase
J8380_RS17590	COG0784	Response regulator, receiver
J8380_RS17590	COG2198	Histidine kinase
J8380_RS17595	COG0745	RESPONSE REGULATOR receiver
J8380_RS17625	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
J8380_RS17630	COG0741	lytic transglycosylase activity
J8380_RS17630	COG1196	nuclear chromosome segregation
J8380_RS17630	COG0739	heme binding
J8380_RS17635	COG2975	iron-sulfur cluster assembly
J8380_RS17640	COG0633	Ferredoxin
J8380_RS17655	COG0316	Belongs to the HesB IscA family
J8380_RS17660	COG0822	iron-sulfur transferase activity
J8380_RS17665	COG1104	cysteine desulfurase activity
J8380_RS17670	COG1959	2 iron, 2 sulfur cluster binding
J8380_RS17675	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
J8380_RS17680	COG1196	nuclear chromosome segregation
J8380_RS17680	COG0741	lytic transglycosylase activity
J8380_RS17680	COG0739	heme binding
J8380_RS17685	COG2975	iron-sulfur cluster assembly
J8380_RS17690	COG0633	Ferredoxin
J8380_RS17695	COG0443	Heat shock 70 kDa protein
J8380_RS17705	COG0316	Belongs to the HesB IscA family
J8380_RS17715	COG1104	cysteine desulfurase activity
J8380_RS17720	COG1959	2 iron, 2 sulfur cluster binding