locus-tag	class	description
L2Y54_RS00010	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
L2Y54_RS00015	COG0586	Pfam SNARE associated Golgi protein
L2Y54_RS00020	COG0583	DNA-binding transcription factor activity
L2Y54_RS00025	COG1741	Belongs to the pirin family
L2Y54_RS00030	COG3038	cytochrome b561
L2Y54_RS00040	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Y54_RS00060	COG5002	protein histidine kinase activity
L2Y54_RS00070	COG0708	Exodeoxyribonuclease III
L2Y54_RS00075	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
L2Y54_RS00080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Y54_RS00085	COG1612	heme a metabolic process
L2Y54_RS00100	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L2Y54_RS00105	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L2Y54_RS00115	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
L2Y54_RS00120	COG1845	cytochrome c oxidase, subunit III
L2Y54_RS00145	COG0109	protoheme IX farnesyltransferase activity
L2Y54_RS00150	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L2Y54_RS00160	COG1999	signal sequence binding
L2Y54_RS00165	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L2Y54_RS00190	COG2161	toxin-antitoxin pair type II binding
L2Y54_RS00215	COG0084	hydrolase, TatD family'
L2Y54_RS00220	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Y54_RS00225	COG2226	methyltransferase
L2Y54_RS00235	COG4206	TonB-dependent receptor
L2Y54_RS00250	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
L2Y54_RS00260	COG1492	cobalamin metabolic process
L2Y54_RS00265	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
L2Y54_RS00270	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L2Y54_RS00280	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L2Y54_RS00285	COG0494	nUDIX hydrolase
L2Y54_RS00325	COG3668	Plasmid stabilization system
L2Y54_RS00345	COG3100	YcgL domain-containing protein
L2Y54_RS00355	COG1166	arginine decarboxylase activity
L2Y54_RS00365	COG4999	Histidine kinase
L2Y54_RS00365	COG3850	Histidine kinase
L2Y54_RS00365	COG2205	protein histidine kinase activity
L2Y54_RS00365	COG3437	response regulator, receiver
L2Y54_RS00370	COG0355	proton-transporting ATP synthase activity, rotational mechanism
L2Y54_RS00380	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
L2Y54_RS00385	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
L2Y54_RS00390	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L2Y54_RS00395	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
L2Y54_RS00400	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L2Y54_RS00405	COG0356	it plays a direct role in the translocation of protons across the membrane
L2Y54_RS00425	COG3275	phosphorelay sensor kinase activity
L2Y54_RS00430	COG0165	Argininosuccinate lyase
L2Y54_RS00435	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
L2Y54_RS00440	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L2Y54_RS00445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Y54_RS00450	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L2Y54_RS00455	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
L2Y54_RS00460	COG1923	regulation of RNA biosynthetic process
L2Y54_RS00465	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L2Y54_RS00510	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
L2Y54_RS00580	COG1217	gtp-binding protein TYPA
L2Y54_RS00620	COG0151	Belongs to the GarS family
L2Y54_RS00630	COG1047	Peptidyl-prolyl cis-trans
L2Y54_RS00635	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Y54_RS00650	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
L2Y54_RS00650	COG0617	tRNA 3'-terminal CCA addition
L2Y54_RS00650	COG0517	IMP dehydrogenase activity
L2Y54_RS00660	COG2871	sodium ion transport
L2Y54_RS00670	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
L2Y54_RS00680	COG1805	sodium ion transport
L2Y54_RS00755	COG3876	Protein conserved in bacteria
L2Y54_RS00780	COG0651	ATP synthesis coupled electron transport
L2Y54_RS00785	COG0651	ATP synthesis coupled electron transport
L2Y54_RS00790	COG0651	ATP synthesis coupled electron transport
L2Y54_RS00825	COG0393	Putative heavy-metal-binding
L2Y54_RS00875	COG1850	ribulose-bisphosphate carboxylase activity
L2Y54_RS00895	COG3002	Belongs to the UPF0753 family
L2Y54_RS00900	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Y54_RS00905	COG3002	Belongs to the UPF0753 family
L2Y54_RS00915	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2Y54_RS00945	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
L2Y54_RS00950	COG0583	DNA-binding transcription factor activity
L2Y54_RS00970	COG0009	L-threonylcarbamoyladenylate synthase
L2Y54_RS01005	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L2Y54_RS01010	COG1850	ribulose-bisphosphate carboxylase activity
L2Y54_RS01040	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
L2Y54_RS01045	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
L2Y54_RS01070	COG1011	Hydrolase
L2Y54_RS01080	COG0494	nUDIX hydrolase
L2Y54_RS01085	COG1218	3'(2'),5'-bisphosphate nucleotidase
L2Y54_RS01095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Y54_RS01170	COG2378	regulation of single-species biofilm formation
L2Y54_RS01190	COG0384	phenazine biosynthesis protein PhzF
L2Y54_RS01210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Y54_RS01250	COG3813	Protein conserved in bacteria
L2Y54_RS01255	COG2808	Putative FMN-binding domain
L2Y54_RS01260	COG2738	Putative neutral zinc metallopeptidase
L2Y54_RS01275	COG0519	Catalyzes the synthesis of GMP from XMP
L2Y54_RS01280	COG3655	Transcriptional regulator
L2Y54_RS01380	COG1024	Enoyl-CoA hydratase
L2Y54_RS01380	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Y54_RS01385	COG1028	Short-chain dehydrogenase reductase Sdr
L2Y54_RS01390	COG0318	PFAM AMP-dependent synthetase and ligase
L2Y54_RS01395	COG0037	tRNA processing
L2Y54_RS01400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Y54_RS01410	COG3550	peptidyl-serine autophosphorylation
L2Y54_RS01420	COG3178	'Phosphotransferase
L2Y54_RS01425	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L2Y54_RS01435	COG1469	GTP cyclohydrolase I activity
L2Y54_RS01450	COG1077	Cell shape determining protein MreB Mrl
L2Y54_RS01455	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
L2Y54_RS01460	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L2Y54_RS01465	COG0596	Alpha beta hydrolase
L2Y54_RS01490	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Y54_RS01495	COG0154	amidase activity
L2Y54_RS01515	COG5265	(ABC) transporter
L2Y54_RS01530	COG0791	NLP P60 protein
L2Y54_RS01535	COG2204	response regulator
L2Y54_RS01540	COG1940	carbohydrate kinase activity
L2Y54_RS01565	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
L2Y54_RS01590	COG0517	IMP dehydrogenase activity
L2Y54_RS01595	COG1944	ATP diphosphatase activity
L2Y54_RS01615	COG3738	Protein conserved in bacteria
L2Y54_RS01630	COG3028	Belongs to the UPF0307 family
L2Y54_RS01635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Y54_RS01640	COG0194	GDP metabolic process
L2Y54_RS01650	COG1187	pseudouridine synthase activity
L2Y54_RS01685	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Y54_RS01690	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
L2Y54_RS01695	COG1104	cysteine desulfurase activity
L2Y54_RS01710	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L2Y54_RS01715	COG2983	Belongs to the UPF0260 family
L2Y54_RS01730	COG1028	Short-chain dehydrogenase reductase Sdr
L2Y54_RS01745	COG1490	D-aminoacyl-tRNA deacylase activity
L2Y54_RS01860	COG0582	viral genome integration into host DNA
L2Y54_RS01865	COG2354	Protein conserved in bacteria
L2Y54_RS01880	COG0714	Associated with various cellular activities
L2Y54_RS01940	COG4452	Inner membrane protein CreD
L2Y54_RS01945	COG1132	(ABC) transporter
L2Y54_RS01960	COG0640	Transcriptional regulator
L2Y54_RS01965	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L2Y54_RS01975	COG1671	Belongs to the UPF0178 family
L2Y54_RS01990	COG0210	DNA helicase
L2Y54_RS02010	COG0259	pyridoxamine-phosphate oxidase activity
L2Y54_RS02025	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
L2Y54_RS02040	COG0107	imidazoleglycerol-phosphate synthase activity
L2Y54_RS02050	COG0140	phosphoribosyl-ATP diphosphatase activity
L2Y54_RS02055	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L2Y54_RS02060	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L2Y54_RS02070	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L2Y54_RS02080	COG2022	thiamine diphosphate biosynthetic process
L2Y54_RS02180	COG1902	pentaerythritol trinitrate reductase activity
L2Y54_RS02185	COG0175	sulfate reduction
L2Y54_RS02190	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Y54_RS02200	COG2895	sulfate adenylyltransferase (ATP) activity
L2Y54_RS02205	COG0471	metal ion transport
L2Y54_RS02205	COG3273	potassium ion transport
L2Y54_RS02220	COG3259	Nickel-dependent hydrogenase
L2Y54_RS02225	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
L2Y54_RS02230	COG3383	formate dehydrogenase (NAD+) activity
L2Y54_RS02235	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L2Y54_RS02285	COG0604	alcohol dehydrogenase
L2Y54_RS02300	COG2204	response regulator
L2Y54_RS02310	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L2Y54_RS02315	COG2027	D-alanyl-D-alanine carboxypeptidase
L2Y54_RS02320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L2Y54_RS02325	COG3954	Phosphoribulokinase
L2Y54_RS02345	COG0116	Belongs to the methyltransferase superfamily
L2Y54_RS02345	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
L2Y54_RS02365	COG0741	lytic transglycosylase activity
L2Y54_RS02380	COG0330	HflC and HflK could
L2Y54_RS02390	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L2Y54_RS02410	COG0513	Belongs to the DEAD box helicase family
L2Y54_RS02425	COG0830	nickel cation binding
L2Y54_RS02430	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
L2Y54_RS02435	COG0804	urea catabolic process
L2Y54_RS02440	COG0832	Belongs to the urease beta subunit family
L2Y54_RS02445	COG0831	urea catabolic process
L2Y54_RS02450	COG0829	nickel cation binding
L2Y54_RS02460	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
L2Y54_RS02475	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L2Y54_RS02490	COG2189	Belongs to the N(4) N(6)-methyltransferase family
L2Y54_RS02505	COG1129	ABC transporter
L2Y54_RS02680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L2Y54_RS02680	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L2Y54_RS02685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Y54_RS02700	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Y54_RS02720	COG0543	2 iron, 2 sulfur cluster binding
L2Y54_RS02720	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Y54_RS02725	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
L2Y54_RS02760	COG3550	peptidyl-serine autophosphorylation
L2Y54_RS02780	COG2081	HI0933 family
L2Y54_RS02790	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L2Y54_RS02795	COG0860	N-Acetylmuramoyl-L-alanine amidase
L2Y54_RS02800	COG0802	atpase or kinase
L2Y54_RS02805	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L2Y54_RS02805	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L2Y54_RS02820	COG3591	Belongs to the peptidase S1B family
L2Y54_RS02825	COG1643	Atp-dependent helicase
L2Y54_RS02840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2Y54_RS02845	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
L2Y54_RS02850	COG1216	Glycosyl transferase, family 2
L2Y54_RS02870	COG0438	transferase activity, transferring glycosyl groups
L2Y54_RS02880	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L2Y54_RS02885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L2Y54_RS02890	COG2255	four-way junction helicase activity
L2Y54_RS02895	COG0824	Thioesterase
L2Y54_RS02900	COG0811	peptide transport
L2Y54_RS02920	COG2885	chlorophyll binding
L2Y54_RS02975	COG0477	Major facilitator Superfamily
L2Y54_RS02980	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L2Y54_RS02985	COG1131	(ABC) transporter
L2Y54_RS03005	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L2Y54_RS03085	COG5433	transposase activity
L2Y54_RS03115	COG0537	adenosine 5'-monophosphoramidase activity
L2Y54_RS03160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Y54_RS03180	COG0751	glycine-tRNA ligase activity
L2Y54_RS03185	COG0697	spore germination
L2Y54_RS03190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Y54_RS03205	COG0129	dihydroxy-acid dehydratase activity
L2Y54_RS03225	COG2205	protein histidine kinase activity
L2Y54_RS03230	COG0745	RESPONSE REGULATOR receiver
L2Y54_RS03235	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L2Y54_RS03280	COG5634	Uncharacterized conserved protein (DUF2278)
L2Y54_RS03290	COG3591	Belongs to the peptidase S1B family
L2Y54_RS03290	COG1864	DNA RNA non-specific endonuclease
L2Y54_RS03310	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L2Y54_RS03330	COG0521	Mo-molybdopterin cofactor biosynthetic process
L2Y54_RS03335	COG1690	Belongs to the RtcB family
L2Y54_RS03395	COG0406	alpha-ribazole phosphatase activity
L2Y54_RS03400	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
L2Y54_RS03405	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L2Y54_RS03410	COG1678	Uncharacterized ACR, COG1678
L2Y54_RS03425	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L2Y54_RS03430	COG0488	(ABC) transporter
L2Y54_RS03440	COG0745	RESPONSE REGULATOR receiver
L2Y54_RS03445	COG2205	protein histidine kinase activity
L2Y54_RS03450	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Y54_RS03495	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
L2Y54_RS03500	COG0301	tRNA thio-modification
L2Y54_RS03515	COG0489	protein tyrosine kinase activity
L2Y54_RS03515	COG3206	protein involved in exopolysaccharide biosynthesis
L2Y54_RS03525	COG0489	protein tyrosine kinase activity
L2Y54_RS03545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Y54_RS03550	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Y54_RS03555	COG0084	hydrolase, TatD family'
L2Y54_RS03585	COG0840	transmembrane signaling receptor activity
L2Y54_RS03635	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L2Y54_RS03640	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L2Y54_RS03650	COG0254	rRNA binding
L2Y54_RS03655	COG4783	chaperone-mediated protein folding
L2Y54_RS03660	COG0281	malic enzyme
L2Y54_RS03675	COG1587	Uroporphyrinogen-III synthase
L2Y54_RS03685	COG5433	transposase activity
L2Y54_RS03690	COG0730	response to heat
L2Y54_RS03695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Y54_RS03715	COG1404	Belongs to the peptidase S8 family
L2Y54_RS03730	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
L2Y54_RS03735	COG2813	Specifically methylates the guanine in position
L2Y54_RS03745	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L2Y54_RS03750	COG5002	protein histidine kinase activity
L2Y54_RS03750	COG2205	protein histidine kinase activity
L2Y54_RS03750	COG0784	Response regulator, receiver
L2Y54_RS03755	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
L2Y54_RS03760	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
L2Y54_RS03785	COG0577	efflux transmembrane transporter activity
L2Y54_RS03785	COG1136	(ABC) transporter
L2Y54_RS03790	COG0577	efflux transmembrane transporter activity
L2Y54_RS03790	COG1136	(ABC) transporter
L2Y54_RS03820	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L2Y54_RS03825	COG0488	(ABC) transporter
L2Y54_RS03845	COG0156	8-amino-7-oxononanoate synthase activity
L2Y54_RS03850	COG0425	Belongs to the sulfur carrier protein TusA family
L2Y54_RS03855	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
L2Y54_RS03865	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L2Y54_RS03900	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Y54_RS03910	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
L2Y54_RS03915	COG0706	membrane insertase activity
L2Y54_RS03920	COG0594	ribonuclease P activity
L2Y54_RS03925	COG0230	Belongs to the bacterial ribosomal protein bL34 family
L2Y54_RS03930	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
L2Y54_RS03935	COG0592	DNA-directed DNA polymerase activity
L2Y54_RS03940	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L2Y54_RS03950	COG0339	signal peptide processing
L2Y54_RS03955	COG0708	Exodeoxyribonuclease III
L2Y54_RS03970	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Y54_RS03995	COG4628	conserved protein (DUF2132)
L2Y54_RS04000	COG4181	ATPase activity
L2Y54_RS04005	COG4804	nuclease activity
L2Y54_RS04015	COG0523	cobalamin synthesis protein
L2Y54_RS04045	COG0493	'glutamate synthase
L2Y54_RS04050	COG1013	pyruvate-flavodoxin oxidoreductase activity
L2Y54_RS04055	COG0674	pyruvate-flavodoxin oxidoreductase activity
L2Y54_RS04065	COG2133	pyrroloquinoline quinone binding
L2Y54_RS04105	COG0243	molybdopterin cofactor binding
L2Y54_RS04110	COG0437	4 iron, 4 sulfur cluster binding
L2Y54_RS04115	COG3302	dmso reductase anchor subunit
L2Y54_RS04125	COG1404	Belongs to the peptidase S8 family
L2Y54_RS04135	COG3302	dmso reductase anchor subunit
L2Y54_RS04140	COG4681	YaeQ
L2Y54_RS04175	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
L2Y54_RS04185	COG2922	Belongs to the Smg family
L2Y54_RS04190	COG0758	DNA mediated transformation
L2Y54_RS04205	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L2Y54_RS04220	COG0131	Imidazoleglycerol-phosphate dehydratase
L2Y54_RS04225	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L2Y54_RS04230	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
L2Y54_RS04235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Y54_RS04240	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Y54_RS04245	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
L2Y54_RS04280	COG0277	FAD linked oxidase domain protein
L2Y54_RS04285	COG1620	l-lactate permease
L2Y54_RS04290	COG2186	Transcriptional regulator
L2Y54_RS04295	COG0247	lactate metabolic process
L2Y54_RS04300	COG1139	Iron-sulfur cluster binding protein
L2Y54_RS04315	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L2Y54_RS04320	COG1192	Involved in chromosome partitioning
L2Y54_RS04325	COG5002	protein histidine kinase activity
L2Y54_RS04325	COG2205	protein histidine kinase activity
L2Y54_RS04325	COG0784	Response regulator, receiver
L2Y54_RS04330	COG0585	pseudouridine synthase activity
L2Y54_RS04340	COG0840	transmembrane signaling receptor activity
L2Y54_RS04345	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
L2Y54_RS04380	COG5000	phosphorelay sensor kinase activity
L2Y54_RS04390	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
L2Y54_RS04400	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
L2Y54_RS04430	COG0179	Fumarylacetoacetate (FAA) hydrolase
L2Y54_RS04435	COG1253	flavin adenine dinucleotide binding
L2Y54_RS04455	COG1773	rubredoxin
L2Y54_RS04460	COG0217	transcriptional regulatory protein
L2Y54_RS04465	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
L2Y54_RS04470	COG0632	four-way junction helicase activity
L2Y54_RS04475	COG3956	TIGRFAM MazG family protein
L2Y54_RS04495	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
L2Y54_RS04515	COG0437	4 iron, 4 sulfur cluster binding
L2Y54_RS04520	COG0243	molybdopterin cofactor binding
L2Y54_RS04540	COG4191	Histidine kinase
L2Y54_RS04545	COG2204	response regulator
L2Y54_RS04550	COG1652	LysM domain
L2Y54_RS04560	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L2Y54_RS04565	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L2Y54_RS04575	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L2Y54_RS04575	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L2Y54_RS04585	COG5000	phosphorelay sensor kinase activity
L2Y54_RS04590	COG2204	response regulator
L2Y54_RS04600	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L2Y54_RS04610	COG0166	Belongs to the GPI family
L2Y54_RS04615	COG0837	glucose binding
L2Y54_RS04620	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
L2Y54_RS04630	COG1640	4-alpha-glucanotransferase
L2Y54_RS04635	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
L2Y54_RS04640	COG0297	glycogen (starch) synthase activity
L2Y54_RS04645	COG0058	SHG alpha-glucan phosphorylase activity
L2Y54_RS04650	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
L2Y54_RS04655	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L2Y54_RS04695	COG0540	Belongs to the ATCase OTCase family
L2Y54_RS04700	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L2Y54_RS04705	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L2Y54_RS04710	COG0196	riboflavin kinase activity
L2Y54_RS04715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2Y54_RS04735	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L2Y54_RS04740	COG2207	Transcriptional regulator
L2Y54_RS04755	COG3220	belongs to the UPF0276 family
L2Y54_RS04785	COG0827	DNA restriction-modification system
L2Y54_RS04795	COG0270	DNA (cytosine-5-)-methyltransferase activity
L2Y54_RS04800	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L2Y54_RS04810	COG0235	Class ii aldolase
L2Y54_RS04815	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
L2Y54_RS04825	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L2Y54_RS04845	COG0315	cyclic pyranopterin monophosphate synthase activity
L2Y54_RS04850	COG0793	Belongs to the peptidase S41A family
L2Y54_RS04855	COG4942	peptidase
L2Y54_RS04865	COG1054	Belongs to the UPF0176 family
L2Y54_RS04875	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
L2Y54_RS04880	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
L2Y54_RS04895	COG1765	OsmC-like protein
L2Y54_RS04900	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
L2Y54_RS04905	COG0791	NLP P60 protein
L2Y54_RS04930	COG5002	protein histidine kinase activity
L2Y54_RS04930	COG2198	Histidine kinase
L2Y54_RS04930	COG0784	Response regulator, receiver
L2Y54_RS04935	COG0142	geranyltranstransferase activity
L2Y54_RS04940	COG0261	This protein binds to 23S rRNA in the presence of protein L20
L2Y54_RS04945	COG0211	Belongs to the bacterial ribosomal protein bL27 family
L2Y54_RS04960	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L2Y54_RS04965	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
L2Y54_RS04970	COG2967	ApaG domain
L2Y54_RS05025	COG5002	protein histidine kinase activity
L2Y54_RS05030	COG0745	RESPONSE REGULATOR receiver
L2Y54_RS05035	COG5002	protein histidine kinase activity
L2Y54_RS05035	COG2176	DNA-directed DNA polymerase activity
L2Y54_RS05040	COG1758	RNA polymerase activity
L2Y54_RS05045	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Y54_RS05075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L2Y54_RS05080	COG2210	Belongs to the sulfur carrier protein TusA family
L2Y54_RS05090	COG1408	metallophosphoesterase
L2Y54_RS05110	COG0840	transmembrane signaling receptor activity
L2Y54_RS05135	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L2Y54_RS05165	COG0500	methyltransferase
L2Y54_RS05175	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
L2Y54_RS05195	COG1056	cytidyltransferase-related domain
L2Y54_RS05195	COG1051	belongs to the nudix hydrolase family
L2Y54_RS05210	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L2Y54_RS05220	COG0418	dihydroorotase activity
L2Y54_RS05230	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
L2Y54_RS05235	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
L2Y54_RS05255	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L2Y54_RS05275	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L2Y54_RS05310	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L2Y54_RS05320	COG4657	Part of a membrane complex involved in electron transport
L2Y54_RS05325	COG4660	Part of a membrane complex involved in electron transport
L2Y54_RS05330	COG4659	FMN binding
L2Y54_RS05335	COG4658	electron transport chain
L2Y54_RS05340	COG4656	Part of a membrane complex involved in electron transport
L2Y54_RS05345	COG1013	pyruvate-flavodoxin oxidoreductase activity
L2Y54_RS05345	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
L2Y54_RS05345	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Y54_RS05345	COG0674	pyruvate-flavodoxin oxidoreductase activity
L2Y54_RS05350	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Y54_RS05350	COG2878	Part of a membrane complex involved in electron transport
L2Y54_RS05360	COG1252	NADH dehydrogenase
L2Y54_RS05365	COG0596	Alpha beta hydrolase
L2Y54_RS05370	COG1131	(ABC) transporter
L2Y54_RS05380	COG1116	anion transmembrane transporter activity
L2Y54_RS05385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Y54_RS05390	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Y54_RS05425	COG4772	TonB-dependent receptor
L2Y54_RS05430	COG0745	RESPONSE REGULATOR receiver
L2Y54_RS05435	COG5002	protein histidine kinase activity
L2Y54_RS05475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Y54_RS05490	COG0535	radical SAM domain protein
L2Y54_RS05500	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
L2Y54_RS05505	COG2002	toxin-antitoxin pair type II binding
L2Y54_RS05515	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L2Y54_RS05535	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
L2Y54_RS05550	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L2Y54_RS05585	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
L2Y54_RS05595	COG1538	Outer membrane efflux protein
L2Y54_RS05675	COG4783	chaperone-mediated protein folding
L2Y54_RS05680	COG2918	glutathione biosynthetic process
L2Y54_RS05685	COG0724	RNA recognition motif
L2Y54_RS05690	COG1872	DUF167
L2Y54_RS05695	COG0762	integral membrane protein
L2Y54_RS05710	COG0826	peptidase U32
L2Y54_RS05715	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
L2Y54_RS05745	COG0732	type I restriction modification DNA specificity domain
L2Y54_RS05765	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
L2Y54_RS05775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Y54_RS05780	COG2046	Belongs to the sulfate adenylyltransferase family
L2Y54_RS05795	COG0563	adenylate kinase activity
L2Y54_RS05800	COG1047	Peptidyl-prolyl cis-trans
L2Y54_RS05810	COG0205	6-phosphofructokinase activity
L2Y54_RS05820	COG0724	RNA recognition motif
L2Y54_RS05835	COG2048	Heterodisulfide reductase, subunit B
L2Y54_RS05840	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L2Y54_RS05850	COG1233	COG1233 Phytoene dehydrogenase and related
L2Y54_RS05855	COG0123	including yeast histone deacetylase and acetoin utilization protein
L2Y54_RS05865	COG0351	phosphomethylpyrimidine kinase
L2Y54_RS05870	COG0352	thiamine-phosphate diphosphorylase activity
L2Y54_RS05880	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
L2Y54_RS05885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Y54_RS05895	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Y54_RS05900	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L2Y54_RS05910	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L2Y54_RS05915	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
L2Y54_RS05920	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L2Y54_RS05925	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L2Y54_RS05930	COG0126	phosphoglycerate kinase activity
L2Y54_RS05965	COG4650	regulator
L2Y54_RS06000	COG0243	molybdopterin cofactor binding
L2Y54_RS06015	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2Y54_RS06035	COG3001	Fructosamine kinase
L2Y54_RS06055	COG0004	ammonium transporteR
L2Y54_RS06070	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
L2Y54_RS06080	COG0741	lytic transglycosylase activity
L2Y54_RS06090	COG1162	GTPase activity
L2Y54_RS06105	COG5433	transposase activity
L2Y54_RS06110	COG0501	Belongs to the peptidase M48B family
L2Y54_RS06115	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L2Y54_RS06175	COG2268	Band 7 protein
L2Y54_RS06190	COG0625	glutathione transferase activity
L2Y54_RS06200	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L2Y54_RS06205	COG4191	Histidine kinase
L2Y54_RS06220	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
L2Y54_RS06225	COG2046	Belongs to the sulfate adenylyltransferase family
L2Y54_RS06250	COG0457	Tetratricopeptide repeat
L2Y54_RS06250	COG0463	Glycosyl transferase, family 2
L2Y54_RS06295	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L2Y54_RS06295	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
L2Y54_RS06300	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
L2Y54_RS06305	COG0792	nuclease activity
L2Y54_RS06310	COG3107	peptidoglycan biosynthetic process
L2Y54_RS06315	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
L2Y54_RS06320	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
L2Y54_RS06330	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L2Y54_RS06335	COG0768	penicillin binding
L2Y54_RS06340	COG0772	Belongs to the SEDS family
L2Y54_RS06345	COG2951	lytic endotransglycosylase activity
L2Y54_RS06355	COG1686	Belongs to the peptidase S11 family
L2Y54_RS06360	COG2921	Belongs to the UPF0250 family
L2Y54_RS06365	COG0321	lipoyl(octanoyl) transferase activity
L2Y54_RS06370	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
L2Y54_RS06380	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L2Y54_RS06385	COG1333	cytochrome c biogenesis protein
L2Y54_RS06395	COG0218	Necessary for normal cell division and for the maintenance of normal septation
L2Y54_RS06400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Y54_RS06410	COG1561	YicC-like family, N-terminal region
L2Y54_RS06425	COG2165	general secretion pathway protein
L2Y54_RS06435	COG2165	general secretion pathway protein
L2Y54_RS06480	COG1477	protein flavinylation
L2Y54_RS06525	COG2194	sulfuric ester hydrolase activity
L2Y54_RS06535	COG3038	cytochrome b561
L2Y54_RS06570	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Y54_RS06585	COG0675	Transposase, IS605 OrfB family
L2Y54_RS06620	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Y54_RS06660	COG2205	protein histidine kinase activity
L2Y54_RS06660	COG3437	response regulator, receiver
L2Y54_RS06660	COG3850	Histidine kinase
L2Y54_RS06660	COG4999	Histidine kinase
L2Y54_RS06690	COG1450	Type ii and iii secretion system protein
L2Y54_RS06730	COG1215	transferase activity, transferring glycosyl groups
L2Y54_RS06745	COG1215	transferase activity, transferring glycosyl groups
L2Y54_RS06755	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
L2Y54_RS06760	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L2Y54_RS06775	COG0247	lactate metabolic process
L2Y54_RS06795	COG0004	ammonium transporteR
L2Y54_RS06820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Y54_RS06875	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
L2Y54_RS06885	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L2Y54_RS06895	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Y54_RS06905	COG2161	toxin-antitoxin pair type II binding
L2Y54_RS06910	COG4115	mRNA cleavage
L2Y54_RS06930	COG1280	lysine exporter protein (LysE YggA)
L2Y54_RS06940	COG1607	acyl-coa hydrolase
L2Y54_RS06950	COG0018	arginyl-trna synthetase
L2Y54_RS06960	COG1187	pseudouridine synthase activity
L2Y54_RS06970	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Y54_RS06975	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
L2Y54_RS07015	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L2Y54_RS07020	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L2Y54_RS07070	COG0675	Transposase, IS605 OrfB family
L2Y54_RS07080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L2Y54_RS07095	COG0617	tRNA 3'-terminal CCA addition
L2Y54_RS07100	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Y54_RS07115	COG3609	addiction module antidote protein, CC2985 family
L2Y54_RS07125	COG0019	diaminopimelate decarboxylase activity
L2Y54_RS07135	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
L2Y54_RS07140	COG1121	(ABC) transporter
L2Y54_RS07145	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L2Y54_RS07150	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
L2Y54_RS07155	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Y54_RS07160	COG1858	cytochrome C peroxidase
L2Y54_RS07185	COG3187	Heat shock protein
L2Y54_RS07190	COG0748	coenzyme F420 binding
L2Y54_RS07195	COG1434	Gram-negative-bacterium-type cell wall biogenesis
L2Y54_RS07200	COG1720	tRNA m6t6A37 methyltransferase activity
L2Y54_RS07205	COG2027	D-alanyl-D-alanine carboxypeptidase
L2Y54_RS07210	COG0729	surface antigen
L2Y54_RS07240	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L2Y54_RS07250	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L2Y54_RS07260	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
L2Y54_RS07265	COG0081	regulation of translation
L2Y54_RS07270	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
L2Y54_RS07275	COG0222	ribosome binding
L2Y54_RS07280	COG0085	RNA polymerase activity
L2Y54_RS07290	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
L2Y54_RS07295	COG0049	tRNA binding
L2Y54_RS07300	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L2Y54_RS07305	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L2Y54_RS07310	COG0051	transcription antitermination factor activity, RNA binding
L2Y54_RS07315	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
L2Y54_RS07320	COG0088	Forms part of the polypeptide exit tunnel
L2Y54_RS07325	COG0089	rRNA binding
L2Y54_RS07335	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
L2Y54_RS07340	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
L2Y54_RS07350	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
L2Y54_RS07355	COG0255	Belongs to the universal ribosomal protein uL29 family
L2Y54_RS07360	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
L2Y54_RS07365	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
L2Y54_RS07370	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
L2Y54_RS07375	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
L2Y54_RS07380	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
L2Y54_RS07385	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
L2Y54_RS07390	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
L2Y54_RS07395	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
L2Y54_RS07405	COG1841	ribosomal large subunit assembly
L2Y54_RS07410	COG0200	Binds to the 23S rRNA
L2Y54_RS07420	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L2Y54_RS07425	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
L2Y54_RS07430	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
L2Y54_RS07435	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
L2Y54_RS07440	COG0202	RNA polymerase activity
L2Y54_RS07455	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
L2Y54_RS07465	COG0357	Ribosomal RNA small subunit methyltransferase G
L2Y54_RS07470	COG1192	Involved in chromosome partitioning
L2Y54_RS07475	COG1475	DNA binding
L2Y54_RS07480	COG0268	Binds directly to 16S ribosomal RNA
L2Y54_RS07485	COG0237	dephospho-CoA kinase activity
L2Y54_RS07490	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
L2Y54_RS07500	COG1722	exodeoxyribonuclease VII activity
L2Y54_RS07505	COG0142	geranyltranstransferase activity
L2Y54_RS07510	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
L2Y54_RS07530	COG0673	inositol 2-dehydrogenase activity
L2Y54_RS07585	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L2Y54_RS07590	COG1459	type II secretion system
L2Y54_RS07605	COG2165	general secretion pathway protein
L2Y54_RS07615	COG3156	type II secretion system protein K
L2Y54_RS07620	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L2Y54_RS07625	COG4464	protein tyrosine phosphatase activity
L2Y54_RS07630	COG0583	DNA-binding transcription factor activity
L2Y54_RS07655	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L2Y54_RS07670	COG0488	(ABC) transporter
L2Y54_RS07680	COG0784	Response regulator, receiver
L2Y54_RS07680	COG5002	protein histidine kinase activity
L2Y54_RS07685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Y54_RS07720	COG0438	transferase activity, transferring glycosyl groups
L2Y54_RS07725	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L2Y54_RS07735	COG1051	belongs to the nudix hydrolase family
L2Y54_RS07740	COG1981	membrane
L2Y54_RS07750	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
L2Y54_RS07765	COG0316	Belongs to the HesB IscA family
L2Y54_RS07775	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
L2Y54_RS07830	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
L2Y54_RS07840	COG1518	maintenance of DNA repeat elements
L2Y54_RS07845	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
L2Y54_RS07910	COG1337	RAMP superfamily
L2Y54_RS07940	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
L2Y54_RS07945	COG1028	Short-chain dehydrogenase reductase Sdr
L2Y54_RS07950	COG0183	Belongs to the thiolase family
L2Y54_RS07960	COG3243	poly(R)-hydroxyalkanoic acid synthase
L2Y54_RS07975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Y54_RS07980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Y54_RS07985	COG1116	anion transmembrane transporter activity
L2Y54_RS07990	COG1238	metal cluster binding
L2Y54_RS07995	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Y54_RS08005	COG0243	molybdopterin cofactor binding
L2Y54_RS08015	COG1116	anion transmembrane transporter activity
L2Y54_RS08015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Y54_RS08020	COG0405	Gamma-glutamyltransferase
L2Y54_RS08045	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L2Y54_RS08060	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Y54_RS08065	COG2414	aldehyde ferredoxin oxidoreductase
L2Y54_RS08090	COG4662	Binding-protein-dependent transport system inner membrane component
L2Y54_RS08100	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Y54_RS08130	COG1238	metal cluster binding
L2Y54_RS08195	COG2326	polyphosphate kinase activity
L2Y54_RS08220	COG0544	peptidyl-prolyl cis-trans isomerase activity
L2Y54_RS08225	COG0740	serine-type endopeptidase activity
L2Y54_RS08230	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
L2Y54_RS08235	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
L2Y54_RS08240	COG0776	regulation of translation
L2Y54_RS08260	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Y54_RS08265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L2Y54_RS08285	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L2Y54_RS08300	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L2Y54_RS08320	COG0328	RNA-DNA hybrid ribonuclease activity
L2Y54_RS08345	COG0488	(ABC) transporter
L2Y54_RS08350	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L2Y54_RS08350	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L2Y54_RS08360	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
L2Y54_RS08365	COG1194	a g-specific adenine glycosylase
L2Y54_RS08460	COG0582	viral genome integration into host DNA
L2Y54_RS08505	COG1309	transcriptional regulator
L2Y54_RS08510	COG0425	Belongs to the sulfur carrier protein TusA family
L2Y54_RS08515	COG2210	Belongs to the sulfur carrier protein TusA family
L2Y54_RS08520	COG1028	Short-chain dehydrogenase reductase Sdr
L2Y54_RS08610	COG3100	YcgL domain-containing protein
L2Y54_RS08610	COG0561	phosphatase activity
L2Y54_RS08615	COG0438	transferase activity, transferring glycosyl groups
L2Y54_RS08620	COG1509	lysine 2,3-aminomutase activity
L2Y54_RS08625	COG1301	dicarboxylic acid transport
L2Y54_RS08630	COG2111	Na H antiporter
L2Y54_RS08630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Y54_RS08640	COG0651	ATP synthesis coupled electron transport
L2Y54_RS08645	COG0651	ATP synthesis coupled electron transport
L2Y54_RS08650	COG1006	Multisubunit Na H antiporter MnhC subunit
L2Y54_RS08675	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Y54_RS08685	COG3852	Histidine kinase
L2Y54_RS08690	COG2204	response regulator
L2Y54_RS08720	COG0174	glutamine synthetase
L2Y54_RS08735	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L2Y54_RS08745	COG1611	Belongs to the LOG family
L2Y54_RS08750	COG5007	Belongs to the BolA IbaG family
L2Y54_RS08760	COG3591	Belongs to the peptidase S1B family
L2Y54_RS08785	COG4789	Type iii secretion
L2Y54_RS08795	COG4792	protein secretion
L2Y54_RS08800	COG4791	protein targeting
L2Y54_RS08810	COG4790	Type iii secretion
L2Y54_RS08865	COG1546	Belongs to the CinA family
L2Y54_RS08865	COG1058	Belongs to the CinA family
L2Y54_RS08870	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
L2Y54_RS08875	COG0483	inositol monophosphate 1-phosphatase activity
L2Y54_RS08880	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Y54_RS08885	COG1047	Peptidyl-prolyl cis-trans
L2Y54_RS08915	COG1715	Restriction endonuclease
L2Y54_RS08930	COG0542	response to heat
L2Y54_RS08965	COG5433	transposase activity
L2Y54_RS08985	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Y54_RS08995	COG0697	spore germination
L2Y54_RS09015	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
L2Y54_RS09040	COG2001	Belongs to the MraZ family
L2Y54_RS09045	COG0275	rRNA processing
L2Y54_RS09060	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L2Y54_RS09065	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L2Y54_RS09070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L2Y54_RS09075	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
L2Y54_RS09080	COG0772	Belongs to the SEDS family
L2Y54_RS09085	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L2Y54_RS09090	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L2Y54_RS09095	COG1181	Belongs to the D-alanine--D-alanine ligase family
L2Y54_RS09100	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L2Y54_RS09110	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L2Y54_RS09115	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
L2Y54_RS09125	COG0739	heme binding
L2Y54_RS09125	COG0741	lytic transglycosylase activity
L2Y54_RS09125	COG1196	nuclear chromosome segregation
L2Y54_RS09130	COG0653	protein targeting
L2Y54_RS09135	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L2Y54_RS09140	COG0494	nUDIX hydrolase
L2Y54_RS09150	COG0513	Belongs to the DEAD box helicase family
L2Y54_RS09160	COG4536	flavin adenine dinucleotide binding
L2Y54_RS09170	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L2Y54_RS09190	COG3738	Protein conserved in bacteria
L2Y54_RS09195	COG0228	four-way junction DNA binding
L2Y54_RS09200	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L2Y54_RS09210	COG0335	large ribosomal subunit rRNA binding
L2Y54_RS09215	COG5001	Diguanylate cyclase
L2Y54_RS09215	COG5002	protein histidine kinase activity
L2Y54_RS09220	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L2Y54_RS09230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L2Y54_RS09235	COG3266	domain, Protein
L2Y54_RS09235	COG4932	domain protein
L2Y54_RS09235	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
L2Y54_RS09250	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
L2Y54_RS09255	COG2814	Major facilitator Superfamily
L2Y54_RS09260	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
L2Y54_RS09260	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
L2Y54_RS09265	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
L2Y54_RS09285	COG0598	Magnesium transport protein CorA
L2Y54_RS09290	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
L2Y54_RS09295	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
L2Y54_RS09300	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
L2Y54_RS09310	COG0356	it plays a direct role in the translocation of protons across the membrane
L2Y54_RS09330	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
L2Y54_RS09335	COG0242	peptide deformylase activity
L2Y54_RS09340	COG0628	permease
L2Y54_RS09375	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
L2Y54_RS09430	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Y54_RS09475	COG1196	nuclear chromosome segregation
L2Y54_RS09475	COG0739	heme binding
L2Y54_RS09475	COG0741	lytic transglycosylase activity
L2Y54_RS09730	COG1104	cysteine desulfurase activity
L2Y54_RS09830	COG2204	response regulator
L2Y54_RS09835	COG5002	protein histidine kinase activity
L2Y54_RS09860	COG0243	molybdopterin cofactor binding
L2Y54_RS09910	COG2304	oxidoreductase activity
L2Y54_RS09930	COG0714	Associated with various cellular activities
L2Y54_RS09935	COG0477	Major facilitator Superfamily
L2Y54_RS09940	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
L2Y54_RS10000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Y54_RS10000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L2Y54_RS10010	COG0659	secondary active sulfate transmembrane transporter activity
L2Y54_RS10030	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L2Y54_RS10040	COG1230	cation diffusion facilitator family transporter
L2Y54_RS10055	COG3118	belongs to the thioredoxin family
L2Y54_RS10055	COG0492	ferredoxin-NADP+ reductase activity
L2Y54_RS10105	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L2Y54_RS10110	COG0789	Transcriptional regulator
L2Y54_RS10120	COG2608	mercury ion transmembrane transporter activity
L2Y54_RS10170	COG2010	Cytochrome c
L2Y54_RS10175	COG3258	Cytochrome c
L2Y54_RS10215	COG0798	PFAM Bile acid sodium symporter
L2Y54_RS10220	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L2Y54_RS10245	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L2Y54_RS10360	COG3311	Transcriptional regulator
L2Y54_RS10365	COG1569	PIN domain
L2Y54_RS10375	COG2003	Belongs to the UPF0758 family
L2Y54_RS10480	COG2894	cell division
L2Y54_RS10530	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L2Y54_RS10540	COG3118	belongs to the thioredoxin family
L2Y54_RS10550	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L2Y54_RS10610	COG2996	Protein conserved in bacteria
L2Y54_RS10625	COG0667	Aldo Keto reductase
L2Y54_RS10630	COG0463	Glycosyl transferase, family 2
L2Y54_RS10635	COG0859	PFAM glycosyl transferase family 9
L2Y54_RS10645	COG1560	Kdo2-lipid A biosynthetic process
L2Y54_RS10650	COG1519	Transferase
L2Y54_RS10655	COG3642	lipopolysaccharide core region biosynthetic process
L2Y54_RS10660	COG0859	PFAM glycosyl transferase family 9
L2Y54_RS10665	COG1368	sulfuric ester hydrolase activity
L2Y54_RS10690	COG5433	transposase activity
L2Y54_RS10705	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L2Y54_RS10710	COG1127	ABC transporter
L2Y54_RS10715	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L2Y54_RS10715	COG3218	ABC-type transport auxiliary lipoprotein component
L2Y54_RS10730	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
L2Y54_RS10745	COG0135	phosphoribosylanthranilate isomerase activity
L2Y54_RS10750	COG4636	protein conserved in cyanobacteria
L2Y54_RS10780	COG0133	tryptophan synthase activity
L2Y54_RS10785	COG0159	tryptophan synthase activity
L2Y54_RS10795	COG0285	dihydrofolate synthase activity
L2Y54_RS10805	COG1286	toxin biosynthetic process
L2Y54_RS10830	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
L2Y54_RS10835	COG1610	YqeY-like protein
L2Y54_RS10840	COG0828	Belongs to the bacterial ribosomal protein bS21 family
L2Y54_RS10845	COG0735	belongs to the Fur family
L2Y54_RS10850	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2Y54_RS10860	COG2914	Belongs to the UPF0125 (RnfH) family
L2Y54_RS10880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L2Y54_RS10890	COG1199	ATP-dependent helicase activity
L2Y54_RS10910	COG0778	Nitroreductase
L2Y54_RS10915	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
L2Y54_RS10930	COG2204	response regulator
L2Y54_RS10940	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
L2Y54_RS10955	COG4804	nuclease activity
L2Y54_RS10975	COG2716	regulation of RNA biosynthetic process
L2Y54_RS10985	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
L2Y54_RS11005	COG0298	carbon dioxide binding
L2Y54_RS11015	COG1773	rubredoxin
L2Y54_RS11045	COG1943	Transposase
L2Y54_RS11055	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
L2Y54_RS11095	COG1959	2 iron, 2 sulfur cluster binding
L2Y54_RS11100	COG1104	cysteine desulfurase activity
L2Y54_RS11105	COG0822	iron-sulfur transferase activity
L2Y54_RS11110	COG0316	Belongs to the HesB IscA family
L2Y54_RS11115	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
L2Y54_RS11120	COG0443	Heat shock 70 kDa protein
L2Y54_RS11130	COG2975	iron-sulfur cluster assembly
L2Y54_RS11135	COG0739	heme binding
L2Y54_RS11135	COG0741	lytic transglycosylase activity
L2Y54_RS11135	COG1196	nuclear chromosome segregation
L2Y54_RS11140	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L2Y54_RS11195	COG0745	RESPONSE REGULATOR receiver
L2Y54_RS11200	COG2198	Histidine kinase
L2Y54_RS11200	COG0784	Response regulator, receiver
L2Y54_RS11200	COG0643	Histidine kinase
L2Y54_RS11205	COG0840	transmembrane signaling receptor activity
L2Y54_RS11220	COG0745	RESPONSE REGULATOR receiver
L2Y54_RS11230	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L2Y54_RS11235	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
L2Y54_RS11240	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L2Y54_RS11245	COG0537	adenosine 5'-monophosphoramidase activity
L2Y54_RS11295	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
L2Y54_RS11295	COG3266	domain, Protein
L2Y54_RS11295	COG4932	domain protein
L2Y54_RS11310	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
L2Y54_RS11320	COG0066	3-isopropylmalate dehydratase activity
L2Y54_RS11340	COG0101	tRNA pseudouridine synthase activity
L2Y54_RS11350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Y54_RS11425	COG0583	DNA-binding transcription factor activity
L2Y54_RS11430	COG2814	Major facilitator Superfamily
L2Y54_RS11455	COG3128	pkhd-type hydroxylase
L2Y54_RS11490	COG2221	Nitrite and sulphite reductase 4Fe-4S
L2Y54_RS11495	COG2221	Nitrite and sulphite reductase 4Fe-4S
L2Y54_RS11500	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
L2Y54_RS11505	COG2923	Belongs to the DsrF TusC family
L2Y54_RS11510	COG2168	tRNA wobble position uridine thiolation
L2Y54_RS11515	COG2920	part of a sulfur-relay system
L2Y54_RS11530	COG0493	'glutamate synthase
L2Y54_RS11560	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
L2Y54_RS11570	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L2Y54_RS11575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Y54_RS11580	COG0149	triose-phosphate isomerase activity
L2Y54_RS11585	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L2Y54_RS11595	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2Y54_RS11600	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2Y54_RS11605	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2Y54_RS11610	COG0649	NAD binding
L2Y54_RS11625	COG1034	ATP synthesis coupled electron transport
L2Y54_RS11630	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
L2Y54_RS11635	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2Y54_RS11645	COG0713	ATP synthesis coupled electron transport
L2Y54_RS11660	COG1007	ATP synthesis coupled electron transport
L2Y54_RS11675	COG0779	Required for maturation of 30S ribosomal subunits
L2Y54_RS11680	COG0195	Participates in both transcription termination and antitermination
L2Y54_RS11680	COG2251	uridine kinase activity
L2Y54_RS11685	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
L2Y54_RS11690	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
L2Y54_RS11695	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L2Y54_RS11700	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L2Y54_RS11710	COG3842	ATPase activity
L2Y54_RS11715	COG1178	ABC-type Fe3 transport system permease component
L2Y54_RS11720	COG1840	ABC-type Fe3 transport system, periplasmic component
L2Y54_RS11725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Y54_RS11740	COG1404	Belongs to the peptidase S8 family
L2Y54_RS11745	COG4124	Belongs to the glycosyl hydrolase 26 family
L2Y54_RS11745	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
L2Y54_RS11750	COG2205	protein histidine kinase activity
L2Y54_RS11755	COG0745	RESPONSE REGULATOR receiver
L2Y54_RS11785	COG0577	efflux transmembrane transporter activity
L2Y54_RS11785	COG1136	(ABC) transporter
L2Y54_RS11790	COG0577	efflux transmembrane transporter activity
L2Y54_RS11790	COG1136	(ABC) transporter
L2Y54_RS11845	COG2193	ferroxidase activity
L2Y54_RS11850	COG1858	cytochrome C peroxidase
L2Y54_RS11855	COG2119	membrane
L2Y54_RS11870	COG1840	ABC-type Fe3 transport system, periplasmic component
L2Y54_RS11875	COG3128	pkhd-type hydroxylase
L2Y54_RS11880	COG4774	siderophore transport
L2Y54_RS11890	COG0811	peptide transport
L2Y54_RS11900	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
L2Y54_RS11910	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
L2Y54_RS11915	COG2885	chlorophyll binding
L2Y54_RS11915	COG3047	cAMP biosynthetic process
L2Y54_RS11925	COG1858	cytochrome C peroxidase
L2Y54_RS11945	COG0602	queuosine metabolic process
L2Y54_RS11950	COG0720	synthase
L2Y54_RS11975	COG3093	addiction module antidote protein HigA
L2Y54_RS12020	COG4636	protein conserved in cyanobacteria
L2Y54_RS12035	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L2Y54_RS12125	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L2Y54_RS12135	COG0850	regulation of cytokinetic process
L2Y54_RS12140	COG2894	cell division
L2Y54_RS12145	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
L2Y54_RS12160	COG1322	Protein conserved in bacteria
L2Y54_RS12175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Y54_RS12180	COG0557	exoribonuclease II activity
L2Y54_RS12195	COG0564	pseudouridine synthase activity
L2Y54_RS12200	COG2885	chlorophyll binding
L2Y54_RS12210	COG0628	permease
L2Y54_RS12215	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
L2Y54_RS12230	COG4232	protein-disulfide reductase activity
L2Y54_RS12240	COG5002	protein histidine kinase activity
L2Y54_RS12240	COG5001	Diguanylate cyclase
L2Y54_RS12250	COG5002	protein histidine kinase activity
L2Y54_RS12250	COG5001	Diguanylate cyclase
L2Y54_RS12260	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
L2Y54_RS12265	COG0459	protein refolding
L2Y54_RS12320	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
L2Y54_RS12375	COG0215	cysteine-tRNA ligase activity
L2Y54_RS12390	COG0280	phosphate acetyltransferase
L2Y54_RS12390	COG0857	belongs to the CobB CobQ family
L2Y54_RS12395	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L2Y54_RS12400	COG1070	Carbohydrate kinase
L2Y54_RS12415	COG0574	Belongs to the PEP-utilizing enzyme family
L2Y54_RS12415	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L2Y54_RS12420	COG1404	Belongs to the peptidase S8 family
L2Y54_RS12425	COG0322	excinuclease ABC activity
L2Y54_RS12440	COG0261	This protein binds to 23S rRNA in the presence of protein L20
L2Y54_RS12440	COG3743	rRNA binding
L2Y54_RS12445	COG2885	chlorophyll binding
L2Y54_RS12460	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L2Y54_RS12470	COG1053	succinate dehydrogenase
L2Y54_RS12480	COG2009	succinate dehydrogenase
L2Y54_RS12490	COG0567	Dehydrogenase, E1 component
L2Y54_RS12495	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L2Y54_RS12505	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Y54_RS12505	COG2111	Na H antiporter
L2Y54_RS12510	COG1006	Multisubunit Na H antiporter MnhC subunit
L2Y54_RS12515	COG0651	ATP synthesis coupled electron transport
L2Y54_RS12520	COG1863	multisubunit Na H antiporter MnhE subunit
L2Y54_RS12525	COG2212	antiporter activity
L2Y54_RS12530	COG1320	monovalent cation:proton antiporter activity
L2Y54_RS12565	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
L2Y54_RS12570	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L2Y54_RS12580	COG4651	solute:proton antiporter activity
L2Y54_RS12580	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Y54_RS12585	COG0589	response to stress
L2Y54_RS12620	COG2951	lytic endotransglycosylase activity
L2Y54_RS12670	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
L2Y54_RS12685	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L2Y54_RS12705	COG1414	Transcriptional regulator
L2Y54_RS12750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Y54_RS12765	COG1358	cellular component organization or biogenesis
L2Y54_RS12785	COG0737	Belongs to the 5'-nucleotidase family
L2Y54_RS12795	COG0438	transferase activity, transferring glycosyl groups
L2Y54_RS12810	COG0438	transferase activity, transferring glycosyl groups
L2Y54_RS12815	COG0745	RESPONSE REGULATOR receiver
L2Y54_RS12825	COG0504	CTP synthase activity
L2Y54_RS12830	COG2877	3-deoxy-8-phosphooctulonate synthase activity
L2Y54_RS12835	COG0148	phosphopyruvate hydratase activity
L2Y54_RS12845	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L2Y54_RS12855	COG0247	lactate metabolic process
L2Y54_RS12860	COG0277	FAD linked oxidase domain protein
L2Y54_RS12865	COG0277	FAD linked oxidase domain protein
L2Y54_RS12870	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L2Y54_RS12875	COG0719	Fe-S assembly protein
L2Y54_RS12880	COG0396	ATPase activity
L2Y54_RS12885	COG0719	Fe-S assembly protein
L2Y54_RS12890	COG2151	metal-sulfur cluster biosynthetic enzyme
L2Y54_RS12895	COG2166	iron-sulfur cluster assembly
L2Y54_RS12915	COG3040	lipid binding
L2Y54_RS12930	COG0028	Belongs to the TPP enzyme family
L2Y54_RS12940	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L2Y54_RS12960	COG0489	protein tyrosine kinase activity
L2Y54_RS13050	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
L2Y54_RS13055	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
L2Y54_RS13060	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
L2Y54_RS13070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L2Y54_RS13085	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
L2Y54_RS13090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Y54_RS13110	COG1272	protein, Hemolysin III
L2Y54_RS13125	COG3647	Membrane
L2Y54_RS13160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L2Y54_RS13165	COG0424	maF-like protein
L2Y54_RS13180	COG0416	fatty acid biosynthetic process
L2Y54_RS13185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L2Y54_RS13190	COG2954	triphosphatase activity
L2Y54_RS13195	COG0513	Belongs to the DEAD box helicase family
L2Y54_RS13200	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L2Y54_RS13205	COG0287	Prephenate dehydrogenase
L2Y54_RS13210	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L2Y54_RS13215	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
L2Y54_RS13225	COG0776	regulation of translation
L2Y54_RS13230	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
L2Y54_RS13235	COG0284	orotidine-5'-phosphate decarboxylase activity
L2Y54_RS13240	COG2915	High frequency lysogenization protein hflD homolog
L2Y54_RS13270	COG0300	oxidoreductase activity
L2Y54_RS13290	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
L2Y54_RS13310	COG1518	maintenance of DNA repeat elements
L2Y54_RS13350	COG0277	FAD linked oxidase domain protein
L2Y54_RS13360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Y54_RS13365	COG0745	RESPONSE REGULATOR receiver
L2Y54_RS13370	COG2205	protein histidine kinase activity
L2Y54_RS13430	COG1518	maintenance of DNA repeat elements
L2Y54_RS13435	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
L2Y54_RS13500	COG1064	alcohol dehydrogenase
L2Y54_RS13505	COG2824	Alkylphosphonate utilization operon protein PhnA
L2Y54_RS13510	COG2860	membrane
L2Y54_RS13515	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Y54_RS13520	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
L2Y54_RS13530	COG0754	glutathionylspermidine amidase activity
L2Y54_RS13555	COG0628	permease
L2Y54_RS13560	COG3459	Glycosyltransferase 36 associated
L2Y54_RS13570	COG3237	CsbD-like
L2Y54_RS13595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Y54_RS13605	COG1136	(ABC) transporter
L2Y54_RS13610	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L2Y54_RS13640	COG0789	Transcriptional regulator
L2Y54_RS13660	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L2Y54_RS13665	COG0477	Major facilitator Superfamily
L2Y54_RS13675	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
L2Y54_RS13690	COG0515	serine threonine protein kinase
L2Y54_RS13690	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Y54_RS13705	COG2326	polyphosphate kinase activity
L2Y54_RS13730	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L2Y54_RS13755	COG0573	inorganic phosphate transmembrane transporter activity
L2Y54_RS13760	COG0573	inorganic phosphate transmembrane transporter activity
L2Y54_RS13765	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L2Y54_RS13770	COG0704	Plays a role in the regulation of phosphate uptake
L2Y54_RS13785	COG0306	phosphate transporter
L2Y54_RS13790	COG1392	Phosphate transport regulator
L2Y54_RS13800	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Y54_RS13830	COG3115	cell septum assembly
L2Y54_RS13835	COG1196	nuclear chromosome segregation
L2Y54_RS13840	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
L2Y54_RS13870	COG0500	methyltransferase
L2Y54_RS13895	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2Y54_RS13900	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2Y54_RS13945	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L2Y54_RS13950	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L2Y54_RS13955	COG1674	ftsk spoiiie
L2Y54_RS13960	COG0492	ferredoxin-NADP+ reductase activity
L2Y54_RS13965	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L2Y54_RS13970	COG3132	Protein of unknown function, DUF480
L2Y54_RS13980	COG0308	aminopeptidase N
L2Y54_RS14000	COG2226	methyltransferase
L2Y54_RS14015	COG0596	Alpha beta hydrolase
L2Y54_RS14025	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
L2Y54_RS14030	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Y54_RS14035	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L2Y54_RS14085	COG2319	Wd-40 repeat
L2Y54_RS14085	COG4249	Peptidase C14 caspase catalytic subunit p20
L2Y54_RS14095	COG0646	methionine synthase
L2Y54_RS14095	COG1410	methionine synthase
L2Y54_RS14135	COG3041	Addiction module toxin RelE StbE family
L2Y54_RS14170	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L2Y54_RS14170	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L2Y54_RS14180	COG0404	The glycine cleavage system catalyzes the degradation of glycine
L2Y54_RS14200	COG3012	SEC-C Motif Domain Protein
L2Y54_RS14205	COG4106	trans-aconitate 2-methyltransferase activity
L2Y54_RS14210	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L2Y54_RS14225	COG0525	valine-tRNA ligase activity
L2Y54_RS14260	COG2264	protein methyltransferase activity
L2Y54_RS14275	COG0583	DNA-binding transcription factor activity
L2Y54_RS14305	COG0515	serine threonine protein kinase
L2Y54_RS14305	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Y54_RS14315	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
L2Y54_RS14330	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Y54_RS14330	COG0519	Catalyzes the synthesis of GMP from XMP
L2Y54_RS14345	COG1570	exodeoxyribonuclease VII activity
L2Y54_RS14370	COG1331	Highly conserved protein containing a thioredoxin domain
L2Y54_RS14380	COG1509	lysine 2,3-aminomutase activity
L2Y54_RS14385	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
L2Y54_RS14390	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
L2Y54_RS14395	COG1862	Preprotein translocase
L2Y54_RS14400	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2Y54_RS14405	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2Y54_RS14425	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L2Y54_RS14430	COG3609	addiction module antidote protein, CC2985 family
L2Y54_RS14435	COG3668	Plasmid stabilization system
L2Y54_RS14465	COG4804	nuclease activity
L2Y54_RS14475	COG0330	HflC and HflK could
L2Y54_RS14510	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L2Y54_RS14550	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
L2Y54_RS14555	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L2Y54_RS14565	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L2Y54_RS14570	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L2Y54_RS14575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Y54_RS14585	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L2Y54_RS14590	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
L2Y54_RS14595	COG0542	response to heat
L2Y54_RS14600	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L2Y54_RS14640	COG0714	Associated with various cellular activities
L2Y54_RS14655	COG0116	Belongs to the methyltransferase superfamily
L2Y54_RS14655	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
L2Y54_RS14660	COG2084	Dehydrogenase
L2Y54_RS14675	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Y54_RS14690	COG0495	leucyl-tRNA aminoacylation
L2Y54_RS14735	COG2719	SpoVR family
L2Y54_RS14740	COG2718	Belongs to the UPF0229 family
L2Y54_RS14745	COG2766	serine protein kinase
L2Y54_RS14755	COG4452	Inner membrane protein CreD
L2Y54_RS14760	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L2Y54_RS14780	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L2Y54_RS14805	COG1028	Short-chain dehydrogenase reductase Sdr
L2Y54_RS14820	COG2862	Uncharacterized protein family, UPF0114
L2Y54_RS14825	COG0179	Fumarylacetoacetate (FAA) hydrolase
L2Y54_RS14835	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L2Y54_RS14845	COG3550	peptidyl-serine autophosphorylation
L2Y54_RS14850	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L2Y54_RS14860	COG0425	Belongs to the sulfur carrier protein TusA family
L2Y54_RS14860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L2Y54_RS14865	COG2197	response regulator
L2Y54_RS14870	COG3850	Histidine kinase
L2Y54_RS14880	COG1797	cobyrinic acid a,c-diamide synthase activity
L2Y54_RS14885	COG1266	CAAX protease self-immunity
L2Y54_RS14890	COG0601	transmembrane transport
L2Y54_RS14895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2Y54_RS14905	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
L2Y54_RS14915	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
L2Y54_RS14925	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L2Y54_RS14950	COG0343	queuine tRNA-ribosyltransferase activity
L2Y54_RS14970	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L2Y54_RS14970	COG1648	precorrin-2 dehydrogenase activity
L2Y54_RS14980	COG1393	Belongs to the ArsC family
L2Y54_RS14985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L2Y54_RS14995	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
L2Y54_RS15025	COG0433	COG0433 Predicted ATPase
L2Y54_RS15035	COG0511	ligase activity, forming carbon-carbon bonds
L2Y54_RS15040	COG0439	Biotin carboxylase
L2Y54_RS15045	COG2264	protein methyltransferase activity
L2Y54_RS15055	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L2Y54_RS15060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Y54_RS15070	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
L2Y54_RS15085	COG1393	Belongs to the ArsC family
L2Y54_RS15105	COG4932	domain protein
L2Y54_RS15105	COG3266	domain, Protein
L2Y54_RS15105	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
L2Y54_RS15115	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Y54_RS15115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Y54_RS15125	COG2974	May be involved in recombination
L2Y54_RS15145	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
L2Y54_RS15155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Y54_RS15190	COG0037	tRNA processing
L2Y54_RS15195	COG0825	malonyl-CoA metabolic process
L2Y54_RS15200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Y54_RS15205	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
L2Y54_RS15215	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
L2Y54_RS15225	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L2Y54_RS15230	COG2137	regulation of response to DNA damage stimulus
L2Y54_RS15235	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
L2Y54_RS15245	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L2Y54_RS15255	COG3243	poly(R)-hydroxyalkanoic acid synthase
L2Y54_RS15265	COG0616	signal peptide processing
L2Y54_RS15265	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L2Y54_RS15270	COG0546	phosphoglycolate phosphatase activity
L2Y54_RS15280	COG1530	ribonuclease E activity
L2Y54_RS15285	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L2Y54_RS15305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Y54_RS15315	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L2Y54_RS15325	COG0180	Tryptophanyl-tRNA synthetase
L2Y54_RS15330	COG1994	Peptidase M50
L2Y54_RS15335	COG0009	L-threonylcarbamoyladenylate synthase
L2Y54_RS15340	COG2917	probably involved in intracellular septation
L2Y54_RS15345	COG2350	Protein conserved in bacteria
L2Y54_RS15350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Y54_RS15360	COG0438	transferase activity, transferring glycosyl groups
L2Y54_RS15370	COG0438	transferase activity, transferring glycosyl groups
L2Y54_RS15405	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
L2Y54_RS15410	COG4181	ATPase activity
L2Y54_RS15420	COG2308	Evidence 4 Homologs of previously reported genes of
L2Y54_RS15475	COG0500	methyltransferase
L2Y54_RS15525	COG0363	glucosamine-6-phosphate deaminase activity
L2Y54_RS15530	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L2Y54_RS15535	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
L2Y54_RS15540	COG3291	Pkd domain containing protein
L2Y54_RS15550	COG1420	regulation of RNA biosynthetic process
L2Y54_RS15560	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L2Y54_RS15565	COG0497	DNA recombination
L2Y54_RS15575	COG0386	Belongs to the glutathione peroxidase family
L2Y54_RS15585	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Y54_RS15595	COG0436	Aminotransferase
L2Y54_RS15685	COG1598	PFAM Uncharacterised protein family UPF0150
L2Y54_RS15700	COG0582	viral genome integration into host DNA
L2Y54_RS15720	COG0330	HflC and HflK could
L2Y54_RS15735	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
L2Y54_RS15740	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L2Y54_RS15745	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L2Y54_RS15750	COG0717	Belongs to the dCTP deaminase family
L2Y54_RS15765	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L2Y54_RS15770	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
L2Y54_RS15785	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Y54_RS15785	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Y54_RS15790	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
L2Y54_RS15795	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L2Y54_RS15825	COG0210	DNA helicase
L2Y54_RS15830	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
L2Y54_RS15865	COG0714	Associated with various cellular activities
L2Y54_RS15870	COG0271	Belongs to the BolA IbaG family
L2Y54_RS15875	COG1959	2 iron, 2 sulfur cluster binding
L2Y54_RS15905	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L2Y54_RS15920	COG3954	Phosphoribulokinase
L2Y54_RS15935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Y54_RS15945	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Y54_RS15965	COG0723	plastoquinol--plastocyanin reductase activity
L2Y54_RS15980	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L2Y54_RS15995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Y54_RS16005	COG3008	intermembrane lipid transfer
L2Y54_RS16010	COG2995	paraquat-inducible protein a
L2Y54_RS16015	COG2995	paraquat-inducible protein a
L2Y54_RS16040	COG0668	transmembrane transport
L2Y54_RS16065	COG0745	RESPONSE REGULATOR receiver
L2Y54_RS16070	COG2205	protein histidine kinase activity
L2Y54_RS16080	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L2Y54_RS16085	COG0305	Participates in initiation and elongation during chromosome replication
L2Y54_RS16090	COG0359	binds to the 23S rRNA
L2Y54_RS16095	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
L2Y54_RS16100	COG0360	Binds together with S18 to 16S ribosomal RNA
L2Y54_RS16105	COG0515	serine threonine protein kinase
L2Y54_RS16105	COG2815	serine threonine protein kinase
L2Y54_RS16135	COG0232	Belongs to the dGTPase family. Type 2 subfamily
L2Y54_RS16140	COG1295	ribonuclease BN
L2Y54_RS16160	COG2197	response regulator
L2Y54_RS16170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L2Y54_RS16175	COG0741	lytic transglycosylase activity
L2Y54_RS16185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Y54_RS16195	COG0006	proline dipeptidase activity
L2Y54_RS16200	COG3079	Belongs to the UPF0149 family
L2Y54_RS16240	COG1126	abc transporter atp-binding protein
L2Y54_RS16245	COG0765	amino acid transport
L2Y54_RS16250	COG4597	amino acid ABC transporter
L2Y54_RS16255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Y54_RS16260	COG0815	Transfers the fatty acyl group on membrane lipoproteins
L2Y54_RS16265	COG4535	Mg2 and Co2 transporter CorC
L2Y54_RS16270	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
L2Y54_RS16275	COG1702	phosphate starvation-inducible protein PhoH
L2Y54_RS16285	COG0784	Response regulator, receiver
L2Y54_RS16285	COG2205	protein histidine kinase activity
L2Y54_RS16285	COG5002	protein histidine kinase activity
L2Y54_RS16290	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L2Y54_RS16295	COG2010	Cytochrome c
L2Y54_RS16315	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
L2Y54_RS16325	COG0697	spore germination
L2Y54_RS16340	COG2270	Major facilitator Superfamily
L2Y54_RS16350	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
L2Y54_RS16350	COG3264	Mechanosensitive ion channel
L2Y54_RS16385	COG3311	Transcriptional regulator
L2Y54_RS16390	COG1674	ftsk spoiiie
L2Y54_RS16405	COG0739	heme binding
L2Y54_RS16505	COG5314	conjugation
L2Y54_RS16510	COG3846	protein secretion by the type IV secretion system
L2Y54_RS16530	COG0776	regulation of translation
L2Y54_RS16535	COG0072	phenylalanine-tRNA ligase activity
L2Y54_RS16535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Y54_RS16540	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
L2Y54_RS16545	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
L2Y54_RS16550	COG0291	Belongs to the bacterial ribosomal protein bL35 family
L2Y54_RS16560	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L2Y54_RS16570	COG0326	Molecular chaperone. Has ATPase activity
L2Y54_RS16590	COG1366	Belongs to the anti-sigma-factor antagonist family
L2Y54_RS16590	COG2202	Pas domain
L2Y54_RS16605	COG4591	ABC-type transport system involved in lipoprotein release permease component
L2Y54_RS16610	COG4591	ABC-type transport system involved in lipoprotein release permease component
L2Y54_RS16615	COG1136	(ABC) transporter
L2Y54_RS16635	COG0138	bifunctional purine biosynthesis protein purh
L2Y54_RS16665	COG1858	cytochrome C peroxidase
L2Y54_RS16685	COG0735	belongs to the Fur family
L2Y54_RS16780	COG1196	nuclear chromosome segregation
L2Y54_RS16790	COG0513	Belongs to the DEAD box helicase family
L2Y54_RS16800	COG0513	Belongs to the DEAD box helicase family
L2Y54_RS16805	COG2814	Major facilitator Superfamily
L2Y54_RS16810	COG0629	single-stranded DNA binding
L2Y54_RS16820	COG2003	Belongs to the UPF0758 family
L2Y54_RS16825	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L2Y54_RS16865	COG0756	dUTP diphosphatase activity
L2Y54_RS16880	COG0183	Belongs to the thiolase family
L2Y54_RS16885	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L2Y54_RS16910	COG1472	Belongs to the glycosyl hydrolase 3 family
L2Y54_RS16915	COG0235	Class ii aldolase
L2Y54_RS16920	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
L2Y54_RS16930	COG3243	poly(R)-hydroxyalkanoic acid synthase
L2Y54_RS16955	COG0559	Belongs to the binding-protein-dependent transport system permease family
L2Y54_RS16965	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
L2Y54_RS16985	COG0372	Belongs to the citrate synthase family
L2Y54_RS17010	COG1185	polyribonucleotide nucleotidyltransferase activity
L2Y54_RS17030	COG2391	methyltransferase activity
L2Y54_RS17040	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
L2Y54_RS17045	COG0484	heat shock protein binding
L2Y54_RS17050	COG0443	Heat shock 70 kDa protein
L2Y54_RS17055	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
L2Y54_RS17060	COG3118	belongs to the thioredoxin family
L2Y54_RS17065	COG5339	Protein conserved in bacteria
L2Y54_RS17095	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L2Y54_RS17095	COG4797	methyltransferase
L2Y54_RS17105	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L2Y54_RS17120	COG0105	UTP biosynthetic process
L2Y54_RS17125	COG0820	rRNA (adenine-C2-)-methyltransferase activity
L2Y54_RS17140	COG0124	histidyl-tRNA synthetase
L2Y54_RS17145	COG2976	Protein conserved in bacteria
L2Y54_RS17150	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2Y54_RS17155	COG1454	alcohol dehydrogenase
L2Y54_RS17160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Y54_RS17165	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Y54_RS17175	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Y54_RS17185	COG1177	transmembrane transport
L2Y54_RS17200	COG1176	ABC-type spermidine putrescine transport system, permease component I
L2Y54_RS17205	COG3842	ATPase activity
L2Y54_RS17215	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
L2Y54_RS17225	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Y54_RS17230	COG1555	photosystem II stabilization
L2Y54_RS17235	COG4608	Belongs to the ABC transporter superfamily
L2Y54_RS17245	COG0564	pseudouridine synthase activity
L2Y54_RS17275	COG0546	phosphoglycolate phosphatase activity
L2Y54_RS17280	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
L2Y54_RS17305	COG3118	belongs to the thioredoxin family
L2Y54_RS17310	COG3245	cytochrome
L2Y54_RS17325	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L2Y54_RS17345	COG0741	lytic transglycosylase activity
L2Y54_RS17350	COG2833	Protein of unknown function (DUF455)
L2Y54_RS17355	COG2379	hydroxypyruvate reductase
L2Y54_RS17395	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
L2Y54_RS17400	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
L2Y54_RS17410	COG1215	transferase activity, transferring glycosyl groups
L2Y54_RS17415	COG3250	beta-galactosidase activity
L2Y54_RS17425	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L2Y54_RS17440	COG4999	Histidine kinase
L2Y54_RS17440	COG3850	Histidine kinase
L2Y54_RS17440	COG3437	response regulator, receiver
L2Y54_RS17440	COG2205	protein histidine kinase activity
L2Y54_RS17445	COG2208	phosphoserine phosphatase activity
L2Y54_RS17545	COG2076	Multidrug Resistance protein
L2Y54_RS17550	COG2076	Multidrug Resistance protein
L2Y54_RS17555	COG0463	Glycosyl transferase, family 2
L2Y54_RS17565	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Y54_RS17580	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Y54_RS17630	COG0348	domain, Protein
L2Y54_RS17635	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
L2Y54_RS17645	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
L2Y54_RS17650	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L2Y54_RS17655	COG3123	guanosine phosphorylase activity
L2Y54_RS17660	COG0312	modulator of DNA gyrase
L2Y54_RS17665	COG0312	modulator of DNA gyrase
L2Y54_RS17670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Y54_RS17685	COG0424	maF-like protein
L2Y54_RS17690	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
L2Y54_RS17700	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
L2Y54_RS17750	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
L2Y54_RS17755	COG4657	Part of a membrane complex involved in electron transport
L2Y54_RS17760	COG2878	Part of a membrane complex involved in electron transport
L2Y54_RS17765	COG4656	Part of a membrane complex involved in electron transport
L2Y54_RS17775	COG4659	FMN binding
L2Y54_RS17780	COG4660	Part of a membrane complex involved in electron transport
L2Y54_RS17785	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L2Y54_RS17815	COG0730	response to heat
L2Y54_RS17820	COG1074	ATP-dependent DNA helicase activity
L2Y54_RS17850	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
L2Y54_RS17865	COG0167	dihydroorotate dehydrogenase activity
L2Y54_RS17870	COG0501	Belongs to the peptidase M48B family
L2Y54_RS17880	COG0489	protein tyrosine kinase activity
L2Y54_RS17895	COG0358	DNA primase activity
L2Y54_RS17900	COG0067	glutamate synthase
L2Y54_RS17900	COG0070	glutamate synthase
L2Y54_RS17900	COG0069	glutamate synthase activity
L2Y54_RS17905	COG0493	'glutamate synthase
L2Y54_RS17930	COG0438	transferase activity, transferring glycosyl groups
L2Y54_RS17955	COG0436	Aminotransferase
L2Y54_RS17990	COG2321	neutral zinc metallopeptidase
L2Y54_RS17995	COG0436	Aminotransferase
L2Y54_RS18000	COG0739	heme binding
L2Y54_RS18010	COG3853	Toxic anion resistance protein (TelA)
L2Y54_RS18035	COG0791	NLP P60 protein
L2Y54_RS18040	COG1652	LysM domain
L2Y54_RS18050	COG0789	Transcriptional regulator
L2Y54_RS18055	COG0415	Belongs to the DNA photolyase family
L2Y54_RS18060	COG0676	glucose-6-phosphate 1-epimerase activity
L2Y54_RS18065	COG0442	prolyl-tRNA aminoacylation
L2Y54_RS18085	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
L2Y54_RS18110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Y54_RS18110	COG3153	acetyltransferase
L2Y54_RS18125	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L2Y54_RS18145	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L2Y54_RS18150	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L2Y54_RS18155	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L2Y54_RS18160	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L2Y54_RS18170	COG0688	phosphatidylethanolamine metabolic process
L2Y54_RS18175	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
L2Y54_RS18190	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
L2Y54_RS18205	COG1132	(ABC) transporter
L2Y54_RS18225	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
L2Y54_RS18230	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Y54_RS18245	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
L2Y54_RS18250	COG0402	S-adenosylhomocysteine deaminase activity
L2Y54_RS18255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L2Y54_RS18270	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L2Y54_RS18280	COG1028	Short-chain dehydrogenase reductase Sdr
L2Y54_RS18305	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Y54_RS18310	COG1012	belongs to the aldehyde dehydrogenase family
L2Y54_RS18315	COG0174	glutamine synthetase
L2Y54_RS18320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Y54_RS18325	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
L2Y54_RS18330	COG3842	ATPase activity
L2Y54_RS18335	COG1176	ABC-type spermidine putrescine transport system, permease component I
L2Y54_RS18340	COG1177	transmembrane transport
L2Y54_RS18350	COG0077	Prephenate dehydratase
L2Y54_RS18350	COG1605	Chorismate mutase
L2Y54_RS18355	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L2Y54_RS18360	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
L2Y54_RS18500	COG0582	viral genome integration into host DNA
L2Y54_RS18520	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L2Y54_RS18525	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L2Y54_RS18545	COG2319	Wd-40 repeat
L2Y54_RS18545	COG4249	Peptidase C14 caspase catalytic subunit p20
L2Y54_RS18605	COG4942	peptidase
L2Y54_RS18620	COG0736	holo-[acyl-carrier-protein] synthase activity
L2Y54_RS18625	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L2Y54_RS18635	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L2Y54_RS18655	COG0481	GTPase activity
L2Y54_RS18665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Y54_RS18695	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L2Y54_RS18700	COG2850	peptidyl-arginine hydroxylation
L2Y54_RS18720	COG4953	penicillin-binding protein 1C
L2Y54_RS18725	COG2373	Large extracellular alpha-helical protein
L2Y54_RS18750	COG0516	GMP reductase activity
L2Y54_RS18750	COG0517	IMP dehydrogenase activity
L2Y54_RS18755	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Y54_RS18760	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L2Y54_RS18765	COG3118	belongs to the thioredoxin family
L2Y54_RS18775	COG5002	protein histidine kinase activity
L2Y54_RS18775	COG0784	Response regulator, receiver
L2Y54_RS18775	COG2205	protein histidine kinase activity
L2Y54_RS18785	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L2Y54_RS18805	COG0588	phosphoglycerate mutase activity
L2Y54_RS18810	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2Y54_RS18815	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
L2Y54_RS18820	COG0505	Belongs to the CarA family
L2Y54_RS18825	COG0489	protein tyrosine kinase activity
L2Y54_RS18830	COG0587	DNA-directed DNA polymerase activity
L2Y54_RS18860	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Y54_RS18865	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Y54_RS18870	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L2Y54_RS18885	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2Y54_RS18890	COG0750	zinc metalloprotease
L2Y54_RS18895	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
L2Y54_RS18900	COG0575	Belongs to the CDS family
L2Y54_RS18905	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L2Y54_RS18910	COG0233	cytoplasmic translational termination
L2Y54_RS18915	COG0528	UMP kinase activity
L2Y54_RS18920	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
L2Y54_RS18925	COG0052	Belongs to the universal ribosomal protein uS2 family
L2Y54_RS18930	COG0024	Methionine aminopeptidase
L2Y54_RS18980	COG1131	(ABC) transporter
L2Y54_RS18985	COG0842	Transport permease protein
L2Y54_RS18990	COG2081	HI0933 family
L2Y54_RS19020	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
L2Y54_RS19030	COG4636	protein conserved in cyanobacteria
L2Y54_RS19040	COG2814	Major facilitator Superfamily
L2Y54_RS19050	COG0012	GTP binding
L2Y54_RS19055	COG0193	aminoacyl-tRNA hydrolase activity
L2Y54_RS19060	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
L2Y54_RS19065	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Y54_RS19075	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
L2Y54_RS19080	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L2Y54_RS19090	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
L2Y54_RS19095	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
L2Y54_RS19100	COG2890	protein-(glutamine-N5) methyltransferase activity
L2Y54_RS19140	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Y54_RS19155	COG2969	positive regulation of protein catabolic process
L2Y54_RS19160	COG0625	glutathione transferase activity
L2Y54_RS19165	COG2857	Cytochrome c1
L2Y54_RS19170	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
L2Y54_RS19175	COG0723	plastoquinol--plastocyanin reductase activity
L2Y54_RS19185	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L2Y54_RS19190	COG0429	hydrolase of the alpha beta-hydrolase fold
L2Y54_RS19235	COG0582	viral genome integration into host DNA
L2Y54_RS19260	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
L2Y54_RS19260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Y54_RS19280	COG0681	Belongs to the peptidase S26 family
L2Y54_RS19310	COG1459	type II secretion system
L2Y54_RS19315	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L2Y54_RS19320	COG0709	Synthesizes selenophosphate from selenide and ATP
L2Y54_RS19325	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
L2Y54_RS19330	COG0033	Phosphoglucomutase
L2Y54_RS19350	COG2363	Small membrane protein
L2Y54_RS19355	COG0742	ribosomal rna small subunit methyltransferase
L2Y54_RS19360	COG2900	Belongs to the SlyX family
L2Y54_RS19365	COG0137	argininosuccinate synthase activity
L2Y54_RS19370	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
L2Y54_RS19390	COG0515	serine threonine protein kinase
L2Y54_RS19390	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Y54_RS19400	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Y54_RS19405	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Y54_RS19445	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Y54_RS19455	COG0579	oxidoreductase
L2Y54_RS19475	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
L2Y54_RS19480	COG2835	tetraacyldisaccharide 4'-kinase activity
L2Y54_RS19485	COG1663	tetraacyldisaccharide 4'-kinase activity
L2Y54_RS19490	COG1132	(ABC) transporter
L2Y54_RS19495	COG0848	biopolymer transport protein
L2Y54_RS19500	COG0811	peptide transport
L2Y54_RS19510	COG0741	lytic transglycosylase activity
L2Y54_RS19525	COG0420	3'-5' exonuclease activity
L2Y54_RS19530	COG2171	N-acyltransferase activity
L2Y54_RS19535	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L2Y54_RS19545	COG1309	transcriptional regulator
L2Y54_RS19555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Y54_RS19560	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L2Y54_RS19570	COG0456	acetyltransferase
L2Y54_RS19575	COG1573	uracil-dna glycosylase
L2Y54_RS19580	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2Y54_RS19585	COG1183	phosphatidylcholine synthase activity
L2Y54_RS19595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Y54_RS19610	COG0348	domain, Protein
L2Y54_RS19615	COG2010	Cytochrome c
L2Y54_RS19630	COG3278	Belongs to the heme-copper respiratory oxidase family
L2Y54_RS19635	COG0438	transferase activity, transferring glycosyl groups
L2Y54_RS19640	COG0583	DNA-binding transcription factor activity
L2Y54_RS19650	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
L2Y54_RS19655	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
L2Y54_RS19665	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
L2Y54_RS19675	COG0517	IMP dehydrogenase activity
L2Y54_RS19675	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L2Y54_RS19680	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L2Y54_RS19695	COG1137	ATPase activity
L2Y54_RS19710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Y54_RS19715	COG1660	Displays ATPase and GTPase activities
L2Y54_RS19725	COG2951	lytic endotransglycosylase activity
L2Y54_RS19735	COG1473	amidohydrolase
L2Y54_RS19755	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
L2Y54_RS19760	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L2Y54_RS19770	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L2Y54_RS19775	COG0227	Belongs to the bacterial ribosomal protein bL28 family
L2Y54_RS19780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Y54_RS19790	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
L2Y54_RS19795	COG0583	DNA-binding transcription factor activity
L2Y54_RS19820	COG2816	NAD+ diphosphatase activity
L2Y54_RS19825	COG1160	GTP binding
L2Y54_RS19830	COG0730	response to heat
L2Y54_RS19840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Y54_RS19890	COG4232	protein-disulfide reductase activity
L2Y54_RS19930	COG0659	secondary active sulfate transmembrane transporter activity
L2Y54_RS19980	COG0583	DNA-binding transcription factor activity
L2Y54_RS19995	COG2346	COG2346, Truncated hemoglobins
L2Y54_RS20000	COG1309	transcriptional regulator
L2Y54_RS20020	COG1136	(ABC) transporter
L2Y54_RS20020	COG0577	efflux transmembrane transporter activity
L2Y54_RS20035	COG2010	Cytochrome c
L2Y54_RS20050	COG4771	TonB-dependent receptor
L2Y54_RS20085	COG0659	secondary active sulfate transmembrane transporter activity
L2Y54_RS20120	COG1242	4 iron, 4 sulfur cluster binding
L2Y54_RS20125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L2Y54_RS20130	COG3154	lipid carrier protein
L2Y54_RS20140	COG0826	peptidase U32
L2Y54_RS20165	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L2Y54_RS20170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Y54_RS20175	COG2181	nitrate reductase activity
L2Y54_RS20180	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
L2Y54_RS20190	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
L2Y54_RS20195	COG2920	part of a sulfur-relay system
L2Y54_RS20200	COG2223	nitrite transmembrane transporter activity
L2Y54_RS20235	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L2Y54_RS20240	COG3850	Histidine kinase
L2Y54_RS20245	COG2197	response regulator
L2Y54_RS20250	COG0346	lactoylglutathione lyase activity
L2Y54_RS20260	COG0701	Predicted permease
L2Y54_RS20270	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
L2Y54_RS20325	COG2304	oxidoreductase activity
L2Y54_RS20355	COG0714	Associated with various cellular activities
L2Y54_RS20360	COG0477	Major facilitator Superfamily
L2Y54_RS20370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Y54_RS20370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L2Y54_RS20380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L2Y54_RS20385	COG1231	oxidoreductase activity
L2Y54_RS20410	COG2205	protein histidine kinase activity
L2Y54_RS20415	COG0745	RESPONSE REGULATOR receiver
L2Y54_RS20420	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L2Y54_RS20430	COG1643	Atp-dependent helicase
L2Y54_RS20435	COG0791	NLP P60 protein
L2Y54_RS20440	COG0742	ribosomal rna small subunit methyltransferase
L2Y54_RS20445	COG0612	Peptidase, M16
L2Y54_RS20450	COG0612	Peptidase, M16
L2Y54_RS20455	COG0552	protein localization to endoplasmic reticulum
L2Y54_RS20460	COG2884	Cell division ATP-binding protein ftsE
L2Y54_RS20465	COG2177	Part of the ABC transporter FtsEX involved in
L2Y54_RS20480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2Y54_RS20485	COG0601	transmembrane transport
L2Y54_RS20495	COG4636	protein conserved in cyanobacteria
L2Y54_RS20515	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L2Y54_RS20520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2Y54_RS20535	COG0728	peptidoglycan biosynthetic process
L2Y54_RS20570	COG0438	transferase activity, transferring glycosyl groups
L2Y54_RS20575	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L2Y54_RS20595	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L2Y54_RS20660	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L2Y54_RS20700	COG4464	protein tyrosine phosphatase activity
L2Y54_RS20750	COG3291	Pkd domain containing protein
L2Y54_RS20750	COG4447	cellulose binding
L2Y54_RS20750	COG5520	Belongs to the glycosyl hydrolase 30 family
L2Y54_RS20755	COG0500	methyltransferase
L2Y54_RS20790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Y54_RS20825	COG1028	Short-chain dehydrogenase reductase Sdr
L2Y54_RS20835	COG0438	transferase activity, transferring glycosyl groups
L2Y54_RS20860	COG0438	transferase activity, transferring glycosyl groups
L2Y54_RS20865	COG0747	negative chemotaxis
L2Y54_RS20945	COG1968	undecaprenyl-diphosphatase activity
L2Y54_RS20955	COG1444	tRNA N-acetyltransferase activity
L2Y54_RS20965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Y54_RS20965	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L2Y54_RS20990	COG4636	protein conserved in cyanobacteria
L2Y54_RS21065	COG2226	methyltransferase
L2Y54_RS21075	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
L2Y54_RS21085	COG2943	transferase activity, transferring hexosyl groups
L2Y54_RS21135	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
L2Y54_RS21140	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
L2Y54_RS21155	COG1278	Cold shock
L2Y54_RS21160	COG0724	RNA recognition motif
L2Y54_RS21185	COG3122	Protein conserved in bacteria
L2Y54_RS21190	COG1373	ATPase (AAA superfamily
L2Y54_RS21200	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L2Y54_RS21220	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L2Y54_RS21260	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L2Y54_RS21270	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Y54_RS21300	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
L2Y54_RS21310	COG0463	Glycosyl transferase, family 2
L2Y54_RS21325	COG0795	lipopolysaccharide-transporting ATPase activity
L2Y54_RS21410	COG1234	tRNA 3'-trailer cleavage
L2Y54_RS21415	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
L2Y54_RS21420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Y54_RS21625	COG1192	Involved in chromosome partitioning