locus-tag class description EQM13_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) EQM13_RS00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) EQM13_RS00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EQM13_RS00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EQM13_RS00040 ENOG4105WN5 stage II sporulation protein EQM13_RS00075 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic EQM13_RS00085 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EQM13_RS00135 ENOG4105D8X mechanosensitive ion channel EQM13_RS00140 ENOG4105VDK protein, conserved in bacteria EQM13_RS00145 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EQM13_RS00150 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) EQM13_RS00155 ENOG4108UUM single-stranded DNA-binding protein EQM13_RS00185 ENOG4105CDU Replicative dna helicase EQM13_RS00205 ENOG4108Z3G 3H domain protein EQM13_RS00215 ENOG4105E1F short-chain dehydrogenase reductase EQM13_RS00225 ENOG4108Z6B deaminase EQM13_RS00235 ENOG4105C19 ABC transporter EQM13_RS00250 ENOG4105EWM Histidine kinase EQM13_RS00300 ENOG4105K4W Could be involved in septation (By similarity) EQM13_RS00310 ENOG4106A3R peptidase EQM13_RS00405 ENOG4105DR5 peptidase EQM13_RS00495 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) EQM13_RS00600 ENOG410834F Transcriptional regulator EQM13_RS00640 ENOG4105CE1 Ferrous iron transport protein b EQM13_RS00660 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase EQM13_RS00685 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) EQM13_RS00690 ENOG41080HT Transcriptional regulator, arsr family EQM13_RS00700 ENOG4105DT3 PTS system, galactitol-specific IIc component EQM13_RS00705 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) EQM13_RS00710 ENOG4105CPQ Dehydrogenase EQM13_RS00715 ENOG4107W7X Aldolase EQM13_RS00725 ENOG4105E1K spore germination protein EQM13_RS00745 ENOG4105CH6 catalase EQM13_RS00750 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EQM13_RS00755 ENOG4105BZU Histidine kinase EQM13_RS00760 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EQM13_RS00775 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) EQM13_RS00795 ENOG4107S9D Alpha beta hydrolase EQM13_RS00800 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) EQM13_RS00805 ENOG4108YZT Adenosylcobinamide kinase EQM13_RS00810 ENOG4107ZET Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) EQM13_RS00885 ENOG4108JIQ Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) EQM13_RS00890 ENOG4108JIP Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) EQM13_RS00895 ENOG4106C6A Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) EQM13_RS00900 ENOG4105C7R Atpase associated with various cellular activities aaa_3 EQM13_RS00905 ENOG4105DAP Nicotinate phosphoribosyltransferase EQM13_RS00925 ENOG4105CE1 Ferrous iron transport protein b EQM13_RS00950 ENOG4105C59 p-type ATPase EQM13_RS00965 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EQM13_RS01000 ENOG4105I03 Flagellin EQM13_RS01020 ENOG4105C4X radical SAM domain protein EQM13_RS01045 ENOG4105BZ1 (ABC) transporter EQM13_RS01050 ENOG4105C6E dna polymerase iii EQM13_RS01055 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) EQM13_RS01095 ENOG4107QMH DNA methylase EQM13_RS01140 ENOG4105EKQ RNA-directed DNA polymerase EQM13_RS01250 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) EQM13_RS01265 ENOG4105MU5 relaxase mobilization nuclease domain protein EQM13_RS01325 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) EQM13_RS01375 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) EQM13_RS01380 ENOG4105C4R Atp-dependent dna helicase EQM13_RS01420 ENOG4105CDU Replicative dna helicase EQM13_RS01430 ENOG4105TIV Cryptic phage CTXphi transcriptional repressor RstR EQM13_RS01495 ENOG41088CC tellurite resistance protein tehB EQM13_RS01525 ENOG4105D6J arsenicaL-resistance protein EQM13_RS01575 ENOG4105D9Q decarboxylase (Beta subunit) EQM13_RS01625 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) EQM13_RS01640 ENOG4108IUW ABC transporter EQM13_RS01660 ENOG4108IMY Transcriptional regulator EQM13_RS01665 ENOG4105WBV Transcriptional regulator EQM13_RS01670 ENOG4108J59 Extracellular solute-binding protein, family 5 EQM13_RS01675 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EQM13_RS01680 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EQM13_RS01690 ENOG4108JQ7 (ABC) transporter EQM13_RS01715 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC EQM13_RS01730 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EQM13_RS01745 ENOG4107RUY (E1 component), alpha subunit EQM13_RS01750 ENOG4105CPP Dehydrogenase, E1 component EQM13_RS01755 ENOG4106Z86 ATP-nad acox kinase EQM13_RS01770 ENOG4105CD5 CoA-binding domain protein EQM13_RS01775 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) EQM13_RS01780 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase EQM13_RS01785 ENOG41081F0 Precorrin-8x methylmutase EQM13_RS01790 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) EQM13_RS01795 ENOG4105CIA precorrin-4 C(11)-methyltransferase EQM13_RS01800 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase EQM13_RS01805 ENOG4105DVK Precorrin-2 c20-methyltransferase EQM13_RS01810 ENOG4105CIA precorrin-4 C(11)-methyltransferase EQM13_RS01815 ENOG4108P62 biosynthesis protein (CbiG) EQM13_RS01820 ENOG4105E4R Precorrin-3B C17-methyltransferase EQM13_RS01825 ENOG4108JTQ reductase EQM13_RS01830 ENOG4107PPM cobalt chelatase EQM13_RS01840 ENOG4108U1V ABC transporter, permease EQM13_RS01850 ENOG4105DC7 peptidase M24 EQM13_RS01865 ENOG4105C7J ABC transporter, permease EQM13_RS01890 ENOG4105DEF Extracellular solute-binding protein, family 5 EQM13_RS01895 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EQM13_RS01910 ENOG4108JQ7 (ABC) transporter EQM13_RS01915 ENOG4107S4Y M20 DapE family protein YgeY EQM13_RS01920 ENOG4105CD3 dihydroorotase EQM13_RS01925 ENOG4105CI2 imidazolone-5-propionate hydrolase EQM13_RS01935 ENOG4105CTZ aminopeptidase c EQM13_RS01950 ENOG4105CTX dehydratase EQM13_RS01970 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EQM13_RS01995 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EQM13_RS02020 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EQM13_RS02030 ENOG4105BZ1 (ABC) transporter EQM13_RS02060 ENOG4105BZ1 (ABC) transporter EQM13_RS02100 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EQM13_RS02125 ENOG4105CID antiterminator EQM13_RS02130 ENOG41069H0 dihydroorotase EC 3.5.2.3 EQM13_RS02195 ENOG4105DA5 (ABC) transporter EQM13_RS02215 ENOG4105EMD TRANSCRIPTIONal EQM13_RS02225 ENOG4105CK1 PTS System EQM13_RS02235 ENOG4105CS2 ec 3.2.1.21 EQM13_RS02240 ENOG4108RVA ribokinase EQM13_RS02245 ENOG4105ETE Transcriptional regulator (LacI family EQM13_RS02275 ENOG4108XBJ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) EQM13_RS02290 ENOG4105DT3 PTS system, galactitol-specific IIc component EQM13_RS02300 ENOG4105DET Rhamnulokinase EQM13_RS02315 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia EQM13_RS02330 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia EQM13_RS02335 ENOG4108JQ1 Dehydrogenase EQM13_RS02340 ENOG4105DG4 malate L-lactate dehydrogenase EQM13_RS02355 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase EQM13_RS02390 ENOG4107QNG Phosphoribosylglycinamide synthetase EQM13_RS02400 ENOG4108V3E phosphoribosylglycinamide formyltransferase EQM13_RS02420 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) EQM13_RS02425 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii EQM13_RS02435 ENOG4105BZW Glycerate kinase EQM13_RS02440 ENOG4108IGT Dipeptidase EQM13_RS02460 ENOG4105CHR reductase EQM13_RS02485 ENOG4105F3H Histidine kinase EQM13_RS02500 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor EQM13_RS02505 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor EQM13_RS02510 ENOG4107QN2 dihydrolipoyl dehydrogenase EQM13_RS02525 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) EQM13_RS02530 ENOG4105NBF ammecr1 domain protein EQM13_RS02540 ENOG4105CXN decarboxylase EQM13_RS02545 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) EQM13_RS02550 ENOG4105X0R protein from nitrogen regulatory protein P-II EQM13_RS02555 ENOG4105X0R protein from nitrogen regulatory protein P-II EQM13_RS02560 ENOG4107QRG dna polymerase iii EQM13_RS02565 ENOG4105MA4 psp1 domain protein EQM13_RS02570 ENOG41084EF Ferredoxin EQM13_RS02575 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) EQM13_RS02580 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) EQM13_RS02585 ENOG4105KRN Transcriptional regulator, abrb family EQM13_RS02600 ENOG4108JIC nucleoside recognition domain protein EQM13_RS02610 ENOG41069ER domain protein EQM13_RS02615 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) EQM13_RS02620 ENOG4105F8V Hydrolase, tatD family EQM13_RS02625 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) EQM13_RS02630 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) EQM13_RS02640 ENOG4107YCR Transcriptional regulator, ARSR family EQM13_RS02675 ENOG4105D1F ATP-binding protein EQM13_RS02680 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A EQM13_RS02685 ENOG4105CPQ Dehydrogenase EQM13_RS02690 ENOG4105DKT Transcriptional regulator EQM13_RS02705 ENOG410787A Pts system, glucitol sorbitol-specific EQM13_RS02720 ENOG4105JFG SpoIID LytB domain protein EQM13_RS02725 ENOG4105W42 Veg protein EQM13_RS02730 ENOG4105S7A ErfK ybiS ycfS ynhG family protein EQM13_RS02760 ENOG4108ZXQ stage ii sporulation protein r EQM13_RS02770 ENOG4105MSI germination protein ypeb EQM13_RS02775 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) EQM13_RS02780 ENOG4108JUB Transcriptional regulator EQM13_RS02785 ENOG4105FRY Dehydrogenase EQM13_RS02805 ENOG4105EQ5 D-Lysine 5,6-aminomutase alpha subunit EQM13_RS02810 ENOG4107CHF 5,6-aminomutase beta subunit EQM13_RS02840 ENOG4105CN1 protease EQM13_RS02845 ENOG4105HIR S-layer domain protein EQM13_RS02895 ENOG4105ETZ PTS System EQM13_RS02900 ENOG4105F3R pts system mannose fructose sorbose family iid EQM13_RS02905 ENOG4105KPI PTS system sorbose subfamily IIB component EQM13_RS02925 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) EQM13_RS02935 ENOG4107104 thymidine kinase EQM13_RS02945 ENOG4105CEU Arginine dihydrolase EQM13_RS02950 ENOG4105DBV ornithine carbamoyltransferase EQM13_RS02975 ENOG4105C32 Amino acid ABC transporter (Permease) EQM13_RS02980 ENOG4105CF8 branched-chain amino acid ABC transporter, permease EQM13_RS02985 ENOG4105C0Z ABC transporter EQM13_RS02990 ENOG4108IV0 ABC, transporter EQM13_RS02995 ENOG4105KZ7 phosphocarrier protein hpr EQM13_RS03000 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EQM13_RS03005 ENOG4108XCU pts system EQM13_RS03010 ENOG4105DAS pts system EQM13_RS03015 ENOG4105ETZ PTS System EQM13_RS03020 ENOG4105F3R pts system mannose fructose sorbose family iid EQM13_RS03035 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) EQM13_RS03040 ENOG4105CPQ Dehydrogenase EQM13_RS03050 ENOG4107QW4 alcohol dehydrogenase EQM13_RS03060 ENOG4105CJR Integral membrane protein (MviN EQM13_RS03065 ENOG4105D7W serine acetyltransferase EQM13_RS03110 ENOG4105CV8 reductase EQM13_RS03130 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EQM13_RS03140 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EQM13_RS03145 ENOG4105D82 Glutamate dehydrogenase EQM13_RS03150 ENOG4108UYI beta-alanyl-CoA ammonia lyase EQM13_RS03155 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme EQM13_RS03160 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) EQM13_RS03165 ENOG4105CBT Fructose-1,6-bisphosphatase EQM13_RS03170 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) EQM13_RS03175 ENOG41082DI 50s ribosomal protein l31 EQM13_RS03180 ENOG4105CBJ Metal-dependent enzyme EQM13_RS03185 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) EQM13_RS03200 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EQM13_RS03210 ENOG4108YZG isomerase EQM13_RS03215 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) EQM13_RS03220 ENOG4105NBU tryptophan transport protein EQM13_RS03225 ENOG4105ESV Glycosyl transferase, family 4 EQM13_RS03230 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase EQM13_RS03235 ENOG4108JUB Transcriptional regulator EQM13_RS03240 ENOG4105CHU acetyl-coa acetyltransferase EQM13_RS03245 ENOG4107QP7 CoA-transferase subunit A EQM13_RS03255 ENOG410865Q Potassium uptake protein EQM13_RS03260 ENOG4105CZN Potassium uptake protein EQM13_RS03270 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EQM13_RS03280 ENOG4105DR5 peptidase EQM13_RS03285 ENOG4105MT0 Sporulation transcriptional regulator spoiiid EQM13_RS03290 ENOG4105DFF Rod shape-determining protein mreb EQM13_RS03295 ENOG4105CGA flagellar basal-body rod protein FlgG EQM13_RS03300 ENOG4105CGA flagellar basal-body rod protein FlgG EQM13_RS03330 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP EQM13_RS03340 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) EQM13_RS03345 ENOG410863U PTS System EQM13_RS03350 ENOG4105C8I hydrolase, family 38 EQM13_RS03360 ENOG4105DG6 mannose-6-phosphate isomerase EQM13_RS03365 ENOG4105C7H Helicase, RecD TraA family EQM13_RS03370 ENOG4105C5T Phosphoribosyl pyrophosphate synthase EQM13_RS03390 ENOG4105E1Q flagellar hook-associated protein EQM13_RS03400 ENOG4105DTJ flagellar hook-associated protein EQM13_RS03405 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) EQM13_RS03410 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) EQM13_RS03430 ENOG41090QV Protein of unknown function DUF115 EQM13_RS03445 ENOG4105C3U ABC transporter EQM13_RS03455 ENOG4105I03 Flagellin EQM13_RS03455 ENOG4105I03 Flagellin EQM13_RS03465 ENOG4105N2W Transcriptional regulator EQM13_RS03470 ENOG4105F1A Pyruvate formate-lyase EQM13_RS03480 ENOG4105VCP PTS System EQM13_RS03490 ENOG4105CK1 PTS System EQM13_RS03510 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase EQM13_RS03520 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase EQM13_RS03525 ENOG4105D2T synthase EQM13_RS03545 ENOG4105CMR udp-glucose 4-epimerase EQM13_RS03560 ENOG4105EMD TRANSCRIPTIONal EQM13_RS03565 ENOG4105CR5 Class II aldolase adducin family protein EQM13_RS03570 ENOG4105CPQ Dehydrogenase EQM13_RS03580 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) EQM13_RS03585 ENOG41090UW PTS System EQM13_RS03590 ENOG4105DT3 PTS system, galactitol-specific IIc component EQM13_RS03595 ENOG4105CHR reductase EQM13_RS03605 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) EQM13_RS03610 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EQM13_RS03615 ENOG4108JQ1 Dehydrogenase EQM13_RS03620 ENOG4105CPQ Dehydrogenase EQM13_RS03625 ENOG4105CPF Cell wall formation (By similarity) EQM13_RS03630 ENOG4105CS2 ec 3.2.1.21 EQM13_RS03640 ENOG4105CK1 PTS System EQM13_RS03650 ENOG4105CYT Selenoprotein B, glycine betaine sarcosine D-proline reductase family EQM13_RS03655 ENOG4105VCP PTS System EQM13_RS03660 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EQM13_RS03665 ENOG4105CE4 GlcNAc 6-P deacetylase EQM13_RS03670 ENOG4105C6K Malic enzyme EQM13_RS03695 ENOG4108RAC Rubrerythrin EQM13_RS03735 ENOG4107RT6 flagellar hook-associated EQM13_RS03740 ENOG4105MQ3 flagellar protein FliS EQM13_RS03755 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving EQM13_RS03760 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) EQM13_RS03765 ENOG4105C8Q Methyl-accepting chemotaxis EQM13_RS03770 ENOG4105BZU Histidine kinase EQM13_RS03775 ENOG4105CXN decarboxylase EQM13_RS03780 ENOG4108SAX Membrane EQM13_RS03785 ENOG4108097 ATP-binding protein EQM13_RS03790 ENOG41072GX Peptidase M22 Glycoprotease EQM13_RS03800 ENOG4105C5H ABC transporter EQM13_RS03815 ENOG4105C1G acyl-Coa dehydrogenase EQM13_RS03820 ENOG4105BZJ Electron transfer flavoprotein EQM13_RS03825 ENOG4105C10 Electron transfer flavoprotein EQM13_RS03835 ENOG4108UQV Membrane EQM13_RS03840 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) EQM13_RS03845 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) EQM13_RS03850 ENOG4107RHR regulatoR EQM13_RS03860 ENOG4105EMN RNA polymerase sigma factor EQM13_RS03895 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EQM13_RS03900 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EQM13_RS03915 ENOG4108HED Type II restriction EQM13_RS03920 ENOG4105D3A purine nucleoside phosphorylase DeoD-type EQM13_RS03925 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EQM13_RS03940 ENOG4105ETZ PTS System EQM13_RS03945 ENOG4105F3R pts system mannose fructose sorbose family iid EQM13_RS03950 ENOG4108JQ1 Dehydrogenase EQM13_RS03960 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) EQM13_RS03975 ENOG4105YHU PTS system EQM13_RS03980 ENOG4105C2X Arabinose 5-phosphate isomerase EQM13_RS03985 ENOG4108JQ1 Dehydrogenase EQM13_RS03995 ENOG4105C5I Dehydrogenase EQM13_RS04000 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EQM13_RS04005 ENOG4105QEK Transcriptional regulator EQM13_RS04010 ENOG4107R7I amino acid EQM13_RS04015 ENOG4105DCF alanine dehydrogenase EQM13_RS04020 ENOG4105EMD TRANSCRIPTIONal EQM13_RS04030 ENOG4105D2N Aldolase EQM13_RS04045 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) EQM13_RS04050 ENOG4105DT3 PTS system, galactitol-specific IIc component EQM13_RS04065 ENOG4108JUB Transcriptional regulator EQM13_RS04075 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) EQM13_RS04080 ENOG4105E8R UPF0173 metal-dependent hydrolase EQM13_RS04085 ENOG4105KGF protein, YerC YecD EQM13_RS04090 ENOG4105C84 Histidine ammonia-lyase EQM13_RS04095 ENOG4105CCS Glutamate formiminotransferase EQM13_RS04110 ENOG4105CI2 imidazolone-5-propionate hydrolase EQM13_RS04120 ENOG4105C4R Atp-dependent dna helicase EQM13_RS04125 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) EQM13_RS04150 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EQM13_RS04155 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EQM13_RS04165 ENOG4108JQ7 (ABC) transporter EQM13_RS04170 ENOG4108J59 Extracellular solute-binding protein, family 5 EQM13_RS04175 ENOG4107QSI ABC, transporter EQM13_RS04185 ENOG4105CXB phosphoribosylaminoimidazole synthetase EQM13_RS04190 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EQM13_RS04195 ENOG4108U5N UPF0316 protein EQM13_RS04205 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) EQM13_RS04210 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) EQM13_RS04245 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) EQM13_RS04260 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) EQM13_RS04270 ENOG4105K56 Transcriptional regulator EQM13_RS04305 ENOG41067QW Transcriptional regulator EQM13_RS04315 ENOG4108JUB Transcriptional regulator EQM13_RS04325 ENOG4108903 Formimidoylglutamase EQM13_RS04330 ENOG4105CE1 Ferrous iron transport protein b EQM13_RS04340 ENOG4105KST dependent repressor EQM13_RS04345 ENOG4105KST dependent repressor EQM13_RS04360 ENOG4105CJ1 ABC, transporter EQM13_RS04365 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family EQM13_RS04370 ENOG4105CZV ABC transporter EQM13_RS04380 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 EQM13_RS04385 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQM13_RS04395 ENOG4105CJ1 ABC, transporter EQM13_RS04415 ENOG4105UQX Mate efflux family protein EQM13_RS04425 ENOG4105UQX Mate efflux family protein EQM13_RS04450 ENOG4105QD4 Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) EQM13_RS04465 ENOG4108JIQ Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) EQM13_RS04470 ENOG4108JIP Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) EQM13_RS04475 ENOG4105M56 Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) EQM13_RS04480 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) EQM13_RS04485 ENOG4105C5F glutamine synthetase EQM13_RS04505 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) EQM13_RS04515 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EQM13_RS04525 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) EQM13_RS04545 ENOG4105BZF Glycosyl transferase (Group 1 EQM13_RS04575 ENOG4108JYZ YitT family EQM13_RS04580 ENOG4108HHA Transketolase EQM13_RS04600 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase EQM13_RS04605 ENOG4105CAK Cell division ATP-binding protein ftsE EQM13_RS04610 ENOG4105CRP Part of the ABC transporter FtsEX involved in EQM13_RS04615 ENOG41063SB peptidase EQM13_RS04635 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) EQM13_RS04640 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) EQM13_RS04660 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) EQM13_RS04670 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) EQM13_RS04690 ENOG4105D4A Cell wall formation (By similarity) EQM13_RS04700 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) EQM13_RS04705 ENOG4105CHW UPF0052 protein EQM13_RS04715 ENOG41062IR nudix hydrolase EQM13_RS04720 ENOG4105CIE May be required for sporulation (By similarity) EQM13_RS04725 ENOG4105KRI phosphocarrier protein (HPr EQM13_RS04730 ENOG4105C0B DNA polymerase III (alpha subunit) EQM13_RS04740 ENOG4105CTQ phosphohexokinase EQM13_RS04750 ENOG4105FS0 cytoplasmic membrane protein EQM13_RS04755 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) EQM13_RS04825 ENOG4107QJE Chromosome Partitioning Protein EQM13_RS04830 ENOG4105FA0 parb-like partition protein EQM13_RS04880 ENOG4105K4H Nlp p60 protein EQM13_RS04895 ENOG4105C9U ATP-dependent DNA helicase RecQ EQM13_RS04950 ENOG4105MU5 relaxase mobilization nuclease domain protein EQM13_RS04990 ENOG4105VYW UPF0251 protein EQM13_RS04995 ENOG4107YH3 SUF system FeS assembly protein, NifU family EQM13_RS05010 ENOG4105WGB oxidoreductase, delta subunit EQM13_RS05065 ENOG4105C8Q Methyl-accepting chemotaxis EQM13_RS05085 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) EQM13_RS05090 ENOG4108C33 Resolvase EQM13_RS05095 ENOG41067QW Transcriptional regulator EQM13_RS05100 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EQM13_RS05105 ENOG4105D9U N-acetyltransferase EQM13_RS05110 ENOG4108JUB Transcriptional regulator EQM13_RS05115 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor EQM13_RS05120 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor EQM13_RS05130 ENOG4105H9W Short-chain dehydrogenase reductase Sdr EQM13_RS05135 ENOG4108JQ1 Dehydrogenase EQM13_RS05140 ENOG4105CHM Aminotransferase EQM13_RS05150 ENOG4105EFZ amidohydrolase EQM13_RS05155 ENOG4105EXC Acyl-transferase EQM13_RS05160 ENOG41087PP glycosyltransferase MGT family EQM13_RS05165 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) EQM13_RS05175 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) EQM13_RS05180 ENOG4105S6R Iron-hydroxamate transporter permease subunit EQM13_RS05190 ENOG4105CTK cobaltochelatase, cobn subunit EQM13_RS05220 ENOG4108U5J '-nucleotidase EQM13_RS05240 ENOG4108V4B ThiJ pfpI EQM13_RS05260 ENOG4105BZ1 (ABC) transporter EQM13_RS05275 ENOG41067SE Tetr family transcriptional regulator EQM13_RS05285 ENOG4105BZ1 (ABC) transporter EQM13_RS05290 ENOG41063VX Inherit from COG: glutaredoxin-related protein EQM13_RS05320 ENOG4105DA5 (ABC) transporter EQM13_RS05340 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) EQM13_RS05350 ENOG41082GB PTS system galactitol-specific transporter subunit IIA EQM13_RS05365 ENOG4105DT3 PTS system, galactitol-specific IIc component EQM13_RS05375 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EQM13_RS05380 ENOG4107T5V SNARE associated Golgi EQM13_RS05390 ENOG4105CPC Aldo Keto reductase EQM13_RS05400 ENOG4105EPR degv family EQM13_RS05410 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) EQM13_RS05415 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EQM13_RS05420 ENOG4105EWC Purine nucleoside phosphorylase EQM13_RS05430 ENOG4105DWF phosphomethylpyrimidine kinase EQM13_RS05435 ENOG4105C5H ABC transporter EQM13_RS05450 ENOG4105C7N Xanthine uracil vitamin C permease EQM13_RS05465 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) EQM13_RS05470 ENOG4105DDK oxidoreductase, beta subunit EQM13_RS05485 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EQM13_RS05490 ENOG4105E39 Enoyl-CoA hydratase EQM13_RS05500 ENOG4105C1G acyl-Coa dehydrogenase EQM13_RS05505 ENOG4105BZJ Electron transfer flavoprotein EQM13_RS05510 ENOG4105C10 Electron transfer flavoprotein EQM13_RS05535 ENOG4105CHR reductase EQM13_RS05540 ENOG4107HP6 Transcriptional regulator EQM13_RS05545 ENOG4107SDT Homocitrate synthase EQM13_RS05550 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EQM13_RS05555 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EQM13_RS05560 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) EQM13_RS05575 ENOG4106ETB IIa component EQM13_RS05590 ENOG41080QX K07048 phosphotriesterase-related protein EQM13_RS05600 ENOG4107HP6 Transcriptional regulator EQM13_RS05620 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) EQM13_RS05625 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) EQM13_RS05640 ENOG4105DKK Benzoate EQM13_RS05675 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EQM13_RS05680 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EQM13_RS05690 ENOG4105C0D helicase EQM13_RS05705 ENOG41081HM 2'-5' rna ligase EQM13_RS05715 ENOG4108K9K Uncharacterised protein family (UPF0236) EQM13_RS05760 ENOG4105BZ1 (ABC) transporter EQM13_RS05765 ENOG4105BZ1 (ABC) transporter EQM13_RS05770 ENOG4107QW8 radical SAM domain protein EQM13_RS05780 ENOG4105BZ8 glutamate synthase EQM13_RS05785 ENOG4107SJI Dehydrogenase EQM13_RS05805 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) EQM13_RS05825 ENOG4105DZ1 carboxypeptidase EQM13_RS05885 ENOG4105DVA methyltransferase EQM13_RS05905 ENOG4105QNR S1 RNA binding domain protein EQM13_RS06015 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein EQM13_RS06020 ENOG4108RTU Aldolase EQM13_RS06050 ENOG4105BZ1 (ABC) transporter EQM13_RS06055 ENOG4105BZ1 (ABC) transporter EQM13_RS06060 ENOG4108QD1 Membrane EQM13_RS06075 ENOG4105C37 (CBS) domain EQM13_RS06095 ENOG4107TVC Glycosyl transferase, family 2 EQM13_RS06100 ENOG4107SIG periplasmic solute binding protein EQM13_RS06105 ENOG4105DIK (ABC) transporter EQM13_RS06110 ENOG4107RPQ ABC transporter EQM13_RS06115 ENOG4105CC5 ABC transporter EQM13_RS06160 ENOG4105CIN aminoacyl-histidine dipeptidase EQM13_RS06170 ENOG4105DFM M18 family aminopeptidase EQM13_RS06175 ENOG410667J hydrolase EQM13_RS06180 ENOG4105N5T Radical SAM Protein EQM13_RS06215 ENOG41080XQ Signal transduction protein with cbs domains EQM13_RS06220 ENOG4105C8Q Methyl-accepting chemotaxis EQM13_RS06250 ENOG4105CSV Glutaminase EQM13_RS06260 ENOG4105DIB Oligopeptide-binding protein EQM13_RS06265 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EQM13_RS06270 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EQM13_RS06275 ENOG4105C3U ABC transporter EQM13_RS06280 ENOG4108JQ7 (ABC) transporter EQM13_RS06290 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) EQM13_RS06295 ENOG4105D17 glycoside hydrolase, family 3 domain protein EQM13_RS06305 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation EQM13_RS06325 ENOG4105CMS peptidase U62, modulator of DNA gyrase EQM13_RS06330 ENOG4105BZ1 (ABC) transporter EQM13_RS06340 ENOG4105C3K feS assembly ATPase SufC EQM13_RS06345 ENOG4105DIW FeS assembly protein SUFB EQM13_RS06350 ENOG4105JRK feS assembly protein SufD EQM13_RS06360 ENOG4108UNV SUF system FeS assembly protein, NifU family EQM13_RS06370 ENOG4105CPF Cell wall formation (By similarity) EQM13_RS06375 ENOG4107RBI VanW family EQM13_RS06385 ENOG4105BZ1 (ABC) transporter EQM13_RS06415 ENOG4105BZ1 (ABC) transporter EQM13_RS06445 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EQM13_RS06455 ENOG4108XRC Protein of unknown function (DUF458) EQM13_RS06470 ENOG4105C5Y PTS System EQM13_RS06475 ENOG4107RFY SbcCD D subunit EQM13_RS06500 ENOG4108Z29 Flavodoxin EQM13_RS06515 ENOG4105C8Q Methyl-accepting chemotaxis EQM13_RS06540 ENOG4105D01 (LipO)protein EQM13_RS06545 ENOG4108UMI ABC transporter, permease EQM13_RS06565 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 EQM13_RS06590 ENOG4105SKN orotidine 5''-phosphate decarboxylase EQM13_RS06595 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) EQM13_RS06600 ENOG4107W93 Dihydroorotate dehydrogenase EQM13_RS06610 ENOG4105C8J )-transporter EQM13_RS06615 ENOG4105E1K spore germination protein EQM13_RS06630 ENOG4105VEQ Cold shock protein EQM13_RS06640 ENOG4105C31 Tryptophanyl-tRNA synthetase EQM13_RS06645 ENOG4108RTU Aldolase EQM13_RS06660 ENOG4105QEK Transcriptional regulator EQM13_RS06665 ENOG4105C5I Dehydrogenase EQM13_RS06670 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) EQM13_RS06680 ENOG4105F3R pts system mannose fructose sorbose family iid EQM13_RS06685 ENOG4105DAS pts system EQM13_RS06690 ENOG4105KPI PTS system sorbose subfamily IIB component EQM13_RS06695 ENOG4105D2X ABC transporter substrate-binding protein EQM13_RS06700 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase EQM13_RS06705 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EQM13_RS06710 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) EQM13_RS06715 ENOG4105DT3 PTS system, galactitol-specific IIc component EQM13_RS06720 ENOG4105CPQ Dehydrogenase EQM13_RS06725 ENOG4105FB2 class II Aldolase EQM13_RS06730 ENOG4107S8T NAD-dependent 4-hydroxybutyrate dehydrogenase EQM13_RS06735 ENOG4105CPQ Dehydrogenase EQM13_RS06745 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) EQM13_RS06790 ENOG4108UGV hypoxanthine phosphoribosyltransferase EQM13_RS06795 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) EQM13_RS06800 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) EQM13_RS06805 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EQM13_RS06810 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) EQM13_RS06825 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) EQM13_RS06830 ENOG4108D32 Methyltransferase EQM13_RS06840 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) EQM13_RS06870 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EQM13_RS06895 ENOG4108QBV Monogalactosyldiacylglycerol synthase EQM13_RS06900 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) EQM13_RS06915 ENOG4105CUT histidyl-tRNA synthetase EQM13_RS06920 ENOG4105BZ1 (ABC) transporter EQM13_RS06925 ENOG4105C22 threonyL-tRNA synthetase EQM13_RS06935 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) EQM13_RS06940 ENOG4105VJV 50s ribosomal protein L35 EQM13_RS06955 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) EQM13_RS06960 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) EQM13_RS06970 ENOG4105CFP Peptidase U32 EQM13_RS06975 ENOG4105C98 muts2 protein EQM13_RS06980 ENOG4105C75 arginyL-tRNA synthetase EQM13_RS06990 ENOG4105EPH radical SAM domain protein EQM13_RS07005 ENOG4107RE7 phosphate butyryltransferase EQM13_RS07105 ENOG4105PW4 Sugar fermentation stimulation protein homolog EQM13_RS07110 ENOG4105C8Q Methyl-accepting chemotaxis EQM13_RS07115 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein EQM13_RS07125 ENOG4105DY9 regulatoR EQM13_RS07145 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EQM13_RS07160 ENOG4105BZ1 (ABC) transporter EQM13_RS07175 ENOG4108UVJ appr-1-p processing domain protein EQM13_RS07190 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 EQM13_RS07230 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) EQM13_RS07235 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) EQM13_RS07240 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) EQM13_RS07245 ENOG41061AI Protein of unknown function (DUF2905) EQM13_RS07250 ENOG4105JFG SpoIID LytB domain protein EQM13_RS07255 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) EQM13_RS07265 ENOG4105VIE preprotein translocase, subunit YajC EQM13_RS07290 ENOG4105DY9 regulatoR EQM13_RS07310 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EQM13_RS07375 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) EQM13_RS07380 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EQM13_RS07385 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) EQM13_RS07390 ENOG4105C5X domain protein EQM13_RS07395 ENOG4105D4P Coproporphyrinogen iii oxidase EQM13_RS07400 ENOG4105VRR gCN5-related N-acetyltransferase EQM13_RS07410 ENOG4105ETD TRANSCRIPTIONal EQM13_RS07425 ENOG4105CK1 PTS System EQM13_RS07430 ENOG4107QSE Dipeptidase EQM13_RS07440 ENOG4105VCP PTS System EQM13_RS07445 ENOG4105C1G acyl-Coa dehydrogenase EQM13_RS07465 ENOG4105DA5 (ABC) transporter EQM13_RS07510 ENOG4105KNA -acetyltransferase EQM13_RS07575 ENOG4105BZ1 (ABC) transporter EQM13_RS07580 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component EQM13_RS07585 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component EQM13_RS07600 ENOG4106N3A copper homeostasis protein cutc EQM13_RS07620 ENOG4105EC3 peptidase S51, dipeptidase E EQM13_RS07695 ENOG4107TB6 phosphoglycerate mutase EQM13_RS07735 ENOG4105IBP Cyclic peptide transporter EQM13_RS07780 ENOG4105CHM Aminotransferase EQM13_RS07795 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme EQM13_RS07840 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) EQM13_RS07845 ENOG4105DKT Transcriptional regulator EQM13_RS07850 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) EQM13_RS07855 ENOG4107QM2 Aldo Keto reductase EQM13_RS07860 ENOG4105DT3 PTS system, galactitol-specific IIc component EQM13_RS07875 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein EQM13_RS07880 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) EQM13_RS07890 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EQM13_RS07900 ENOG41090UW PTS System EQM13_RS07905 ENOG4105DT3 PTS system, galactitol-specific IIc component EQM13_RS07910 ENOG4108JQ1 Dehydrogenase EQM13_RS07915 ENOG4105CXK mandelate racemase muconate lactonizing EQM13_RS07920 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase EQM13_RS07940 ENOG4105C9M aspartyl-trna synthetase EQM13_RS07960 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) EQM13_RS07965 ENOG4105S2F EQM13_RS07980 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) EQM13_RS07985 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) EQM13_RS08005 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) EQM13_RS08010 ENOG4105CJ1 ABC, transporter EQM13_RS08015 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) EQM13_RS08040 ENOG4105VXP Protein of unknown function DUF86 EQM13_RS08055 ENOG4105DFA alanine racemase domain protein EQM13_RS08060 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) EQM13_RS08070 ENOG4105DBK s4 domain protein EQM13_RS08075 ENOG4105MMF Cell division protein DIVIVA EQM13_RS08090 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) EQM13_RS08095 ENOG4105C34 Pseudouridine synthase EQM13_RS08100 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) EQM13_RS08110 ENOG4105DSJ YicC domain protein EQM13_RS08115 ENOG4105KC4 UPF0296 protein EQM13_RS08120 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) EQM13_RS08130 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase EQM13_RS08135 ENOG4105C25 Primosomal protein n' EQM13_RS08140 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EQM13_RS08145 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) EQM13_RS08155 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B EQM13_RS08170 ENOG4105D9P serine threonine protein kinase EQM13_RS08175 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) EQM13_RS08180 ENOG4105DJV ribulose-phosphate 3-epimerase EQM13_RS08200 ENOG4105VB9 50S ribosomal protein l28 EQM13_RS08205 ENOG4108ZAA Alkaline-shock protein EQM13_RS08210 ENOG4105DP4 dak2 domain fusion protein ylov EQM13_RS08215 ENOG4105CB5 ATP-dependent DNA helicase recG EQM13_RS08220 ENOG4106H78 methyltransferase EQM13_RS08235 ENOG4105H20 Sporulation integral membrane protein YlbJ EQM13_RS08240 ENOG4105D78 K07001 NTE family protein EQM13_RS08250 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) EQM13_RS08265 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) EQM13_RS08270 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EQM13_RS08290 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) EQM13_RS08310 ENOG4105K5M 30s ribosomal protein S16 EQM13_RS08315 ENOG4105VB6 UPF0109 protein EQM13_RS08320 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) EQM13_RS08330 ENOG4105BZ1 (ABC) transporter EQM13_RS08340 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) EQM13_RS08345 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EQM13_RS08355 ENOG4105VM1 flagellar EQM13_RS08365 ENOG4105C0P Mg chelatase subunit ChlI EQM13_RS08370 ENOG4105C79 DNA protecting protein DprA EQM13_RS08375 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) EQM13_RS08390 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) EQM13_RS08395 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) EQM13_RS08400 ENOG4108ZC9 flagellar basal-body rod protein flgc EQM13_RS08405 ENOG4105VQ0 flagellar hook-basal body complex protein fliE EQM13_RS08410 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) EQM13_RS08415 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EQM13_RS08445 ENOG410822I Flagellar hook capping protein EQM13_RS08455 ENOG4105BZE flagellar hook protein, FlgE EQM13_RS08465 ENOG4105E14 MotA TolQ exbB proton channel EQM13_RS08470 ENOG4106VK6 Flagellar motor protein EQM13_RS08480 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EQM13_RS08485 ENOG4105DD5 Flagellar motor switch protein EQM13_RS08490 ENOG4107YTP response regulator receiver protein EQM13_RS08500 ENOG4105CN7 Flagellar biosynthetic protein FliP EQM13_RS08505 ENOG4105VS8 Flagellar biosynthetic protein fliq EQM13_RS08510 ENOG4105D19 Role in flagellar biosynthesis (By similarity) EQM13_RS08515 ENOG4105D00 flagellar biosynthetic protein flhB EQM13_RS08520 ENOG4105D7B Flagellar biosynthesis protein flha EQM13_RS08525 ENOG4105FZW flagellar biosynthesis regulator FlhF EQM13_RS08540 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) EQM13_RS08545 ENOG4105CBS Chea signal transduction histidine kinase EQM13_RS08550 ENOG4108V3W Chemotaxis protein, CheW EQM13_RS08560 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) EQM13_RS08565 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQM13_RS08590 ENOG4105C1G acyl-Coa dehydrogenase EQM13_RS08600 ENOG4105CPF Cell wall formation (By similarity) EQM13_RS08605 ENOG4105CE9 30S ribosomal protein S2 EQM13_RS08610 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) EQM13_RS08620 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) EQM13_RS08630 ENOG4105KNE Phosphatidate cytidylyltransferase EQM13_RS08635 ENOG4105DZP Membrane-associated zinc metalloprotease EQM13_RS08645 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) EQM13_RS08650 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) EQM13_RS08655 ENOG4105CHV Transcription elongation factor NusA EQM13_RS08665 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) EQM13_RS08670 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) EQM13_RS08675 ENOG4105SFS phosphoesterase RecJ domain protein EQM13_RS08680 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) EQM13_RS08685 ENOG4105DTN riboflavin biosynthesis protein ribF EQM13_RS08690 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) EQM13_RS08695 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) EQM13_RS08705 ENOG4105C1V Peptidase, M16 EQM13_RS08710 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) EQM13_RS08725 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit EQM13_RS08730 ENOG4105CNU cell division protein FtsK EQM13_RS08735 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) EQM13_RS08740 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase EQM13_RS08750 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) EQM13_RS08760 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) EQM13_RS08775 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) EQM13_RS08780 ENOG4105MCT stage V sporulation protein S EQM13_RS08785 ENOG4105DB7 PHP domain protein EQM13_RS08795 ENOG4105CHM Aminotransferase EQM13_RS08805 ENOG4105CJ1 ABC, transporter EQM13_RS08830 ENOG4108IUW ABC transporter EQM13_RS08865 ENOG4105CDA abc transporter atp-binding protein EQM13_RS08870 ENOG4105E5Q amino acid AbC transporter EQM13_RS08880 ENOG4105E0X reductase EQM13_RS08885 ENOG4107HP6 Transcriptional regulator EQM13_RS08890 ENOG4107YB6 acetyltransferase, (GNAT) family EQM13_RS08905 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EQM13_RS08910 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) EQM13_RS08915 ENOG4105DJV ribulose-phosphate 3-epimerase EQM13_RS08925 ENOG4105E98 transcriptional regulator DeoR family EQM13_RS08930 ENOG4105CXI aluminum resistance protein EQM13_RS08935 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) EQM13_RS08945 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) EQM13_RS08950 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) EQM13_RS08955 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EQM13_RS08990 ENOG4105BZU Histidine kinase EQM13_RS08995 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) EQM13_RS09000 ENOG4105F6E Acyl-transferase EQM13_RS09010 ENOG4105KHN chorismate mutase EQM13_RS09020 ENOG4105CBX hi0933 family EQM13_RS09025 ENOG4105CVJ phosphoglycerate mutase EQM13_RS09030 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) EQM13_RS09040 ENOG4105DQU oxidoreductase, subunit beta EQM13_RS09045 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein EQM13_RS09055 ENOG4107QSA Oxaloacetate decarboxylase EQM13_RS09070 ENOG4105FE9 pseudouridine synthase EQM13_RS09080 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) EQM13_RS09085 ENOG4105DZ1 carboxypeptidase EQM13_RS09090 ENOG4105KBJ sporulation protein ytfj EQM13_RS09100 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) EQM13_RS09105 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) EQM13_RS09110 ENOG4108Z4T Peptidase M50 EQM13_RS09115 ENOG4105DZ1 carboxypeptidase EQM13_RS09130 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EQM13_RS09155 ENOG4105CKK Glycosyl transferase, family 2 EQM13_RS09170 ENOG4107QQR Sporulation EQM13_RS09200 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EQM13_RS09205 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EQM13_RS09210 ENOG4108J59 Extracellular solute-binding protein, family 5 EQM13_RS09215 ENOG4105S1Z Stage IV sporulation protein B EQM13_RS09220 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) EQM13_RS09225 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) EQM13_RS09230 ENOG4105DX0 Hemolysin A EQM13_RS09250 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) EQM13_RS09280 ENOG4108ZSR alkaline shock protein EQM13_RS09305 ENOG4105KQ4 Stage iii sporulation protein ad EQM13_RS09320 ENOG4105CD2 stage iii sporulation protein aa EQM13_RS09330 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) EQM13_RS09380 ENOG4106A3R peptidase EQM13_RS09395 ENOG4105CZX twitching motility protein EQM13_RS09400 ENOG4107QHF type ii secretion system protein e EQM13_RS09405 ENOG4108K9K Uncharacterised protein family (UPF0236) EQM13_RS09415 ENOG41068JE domain protein EQM13_RS09420 ENOG4107XBN GntR Family Transcriptional Regulator EQM13_RS09425 ENOG4105CBX hi0933 family EQM13_RS09430 ENOG4105WCA Ferredoxin EQM13_RS09460 ENOG4105BZU Histidine kinase EQM13_RS09480 ENOG4105C87 Aminotransferase class I and II EQM13_RS09490 ENOG4106V2I dimethylaminohydrolase EQM13_RS09495 ENOG4108JUB Transcriptional regulator EQM13_RS09510 ENOG4105BZ1 (ABC) transporter EQM13_RS09520 ENOG4105DTQ mandelate racemase muconate lactonizing EQM13_RS09550 ENOG4105K95 (LipO)protein EQM13_RS09555 ENOG4108YM7 Gcn5-related n-acetyltransferase EQM13_RS09580 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) EQM13_RS09585 ENOG4105D6A Electron transport complex EQM13_RS09590 ENOG41080WF Electron transport complex, RnfABCDGE type, G subunit EQM13_RS09595 ENOG4105DZB Electron transport complex EQM13_RS09600 ENOG4105DGN Electron transport complex EQM13_RS09605 ENOG4107SVV electron transport complex, RnfABCDGE type, B subunit EQM13_RS09625 ENOG4105DZW Dipeptidase EQM13_RS09630 ENOG4105D2N Aldolase EQM13_RS09640 ENOG4105CPQ Dehydrogenase EQM13_RS09655 ENOG4105DT3 PTS system, galactitol-specific IIc component EQM13_RS09665 ENOG4105CPQ Dehydrogenase EQM13_RS09675 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) EQM13_RS09720 ENOG4105CB5 ATP-dependent DNA helicase recG EQM13_RS09730 ENOG4105C7J ABC transporter, permease EQM13_RS09745 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) EQM13_RS09770 ENOG4105C5R Aminotransferase EQM13_RS09780 ENOG4105ZHF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) EQM13_RS09785 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) EQM13_RS09835 ENOG4108BN2 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) EQM13_RS09840 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) EQM13_RS09880 ENOG4105H9W Short-chain dehydrogenase reductase Sdr EQM13_RS09885 ENOG4107S8T NAD-dependent 4-hydroxybutyrate dehydrogenase EQM13_RS09900 ENOG4105KPI PTS system sorbose subfamily IIB component EQM13_RS09905 ENOG4105C5I Dehydrogenase EQM13_RS09910 ENOG4105ETZ PTS System EQM13_RS09920 ENOG4105D2N Aldolase EQM13_RS09925 ENOG4105CPQ Dehydrogenase EQM13_RS09930 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EQM13_RS09945 ENOG4105DA5 (ABC) transporter EQM13_RS09970 ENOG4105DYB Isoaspartyl dipeptidase EQM13_RS09975 ENOG4105CSX c4-dicarboxylate anaerobic carrier EQM13_RS10010 ENOG4105CJ1 ABC, transporter EQM13_RS10015 ENOG4108ZGX Histidine kinase EQM13_RS10020 ENOG4105WH1 Two component transcriptional regulator luxr family EQM13_RS10030 ENOG4105RHY Pfam:UPF0157 EQM13_RS10045 ENOG4105VEQ Cold shock protein EQM13_RS10060 ENOG4105CTS PTS system mannitol-specific EQM13_RS10065 ENOG4105DJV ribulose-phosphate 3-epimerase EQM13_RS10070 ENOG4106P19 photosystem i assembly btpa EQM13_RS10075 ENOG4105DT3 PTS system, galactitol-specific IIc component EQM13_RS10080 ENOG41090UW PTS System EQM13_RS10085 ENOG4105CN9 Peptidase m42 family protein EQM13_RS10100 ENOG4108IV0 ABC, transporter EQM13_RS10105 ENOG4105C0Z ABC transporter EQM13_RS10115 ENOG4105C32 Amino acid ABC transporter (Permease) EQM13_RS10155 ENOG4107QRT dEAD DEAH box helicase EQM13_RS10190 ENOG4105MZG transcriptional modulator of maze toxin, mazf EQM13_RS10200 ENOG4105DZR Type I site-specific deoxyribonuclease EQM13_RS10220 ENOG4105CVR type I restriction-modification system EQM13_RS10230 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) EQM13_RS10270 ENOG4105CJR Integral membrane protein (MviN EQM13_RS10310 ENOG41071TK Uncharacterised protein family (UPF0150) EQM13_RS10370 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) EQM13_RS10375 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) EQM13_RS10510 ENOG4108K9K Uncharacterised protein family (UPF0236) EQM13_RS10515 ENOG4105C4R Atp-dependent dna helicase EQM13_RS10610 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EQM13_RS10620 ENOG4107QQG Dehydrogenase EQM13_RS10625 ENOG4105J5G Transferase hexapeptide repeat containing protein EQM13_RS10640 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase EQM13_RS10660 ENOG4105D3Q Sugar transferase EQM13_RS10670 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EQM13_RS10690 ENOG4108RB3 Capsular polysaccharide biosynthesis protein EQM13_RS10695 ENOG4107YJ4 chain length determinant protein EQM13_RS10700 ENOG4105HTX biosynthesis protein EQM13_RS10710 ENOG4105CVJ phosphoglycerate mutase EQM13_RS10740 ENOG4105BZU Histidine kinase EQM13_RS10745 ENOG4108KXV response regulator EQM13_RS10760 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQM13_RS10765 ENOG4105CJN penicillin-binding protein EQM13_RS10770 ENOG4105DBI uridine monophosphokinase EQM13_RS10775 ENOG4105CFP Peptidase U32 EQM13_RS10795 ENOG41084CE UPF0342 protein EQM13_RS10800 ENOG4105CN5 Metallo-Beta-Lactamase EQM13_RS10805 ENOG4105I3K Ferric uptake regulator, Fur family EQM13_RS10815 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) EQM13_RS10825 ENOG4105VBH UPF0297 protein EQM13_RS10830 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) EQM13_RS10850 ENOG41082EK Restriction modification system DNA (Specificity EQM13_RS10885 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins EQM13_RS10915 ENOG4105EXW epimerase dehydratase EQM13_RS10920 ENOG4105C8T Leucyl-tRNA synthetase EQM13_RS10930 ENOG4105D1H recombination factor protein RarA EQM13_RS10935 ENOG4106M28 alanine racemase domain protein EQM13_RS10945 ENOG4105EQ5 D-Lysine 5,6-aminomutase alpha subunit EQM13_RS10950 ENOG4105KIJ D-ornithine aminomutase S component EQM13_RS10955 ENOG4107RH1 pyridoxal-5'-phosphate-dependent protein beta subunit EQM13_RS10960 ENOG4105Z5Q EQM13_RS10965 ENOG4108KR4 dihydrodipicolinate reductase EQM13_RS10970 ENOG4108JUB Transcriptional regulator EQM13_RS10975 ENOG4105BZU Histidine kinase EQM13_RS10980 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EQM13_RS10985 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase EQM13_RS10990 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) EQM13_RS10995 ENOG4105WR5 sporulation protein, YlmC YmxH family EQM13_RS11000 ENOG4105E65 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQM13_RS11005 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQM13_RS11010 ENOG4105FFI sigma-e processing peptidase spoiiga EQM13_RS11015 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) EQM13_RS11020 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) EQM13_RS11025 ENOG4105K67 small basic protein EQM13_RS11045 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EQM13_RS11055 ENOG4105CNI cell division protein FtsW EQM13_RS11060 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) EQM13_RS11065 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) EQM13_RS11070 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) EQM13_RS11075 ENOG4105CJN penicillin-binding protein EQM13_RS11085 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) EQM13_RS11090 ENOG4108V6E Cell division protein mraZ EQM13_RS11115 ENOG4105C3G gtp-binding protein EQM13_RS11125 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) EQM13_RS11130 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) EQM13_RS11145 ENOG4105X71 Membrane EQM13_RS11160 ENOG4105CDY transcriptional regulatory protein EQM13_RS11165 ENOG4107RA1 nh(3)-dependent nad( ) synthetase EQM13_RS11170 ENOG4107QSE Dipeptidase EQM13_RS11175 ENOG4105HF0 Membrane EQM13_RS11190 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein EQM13_RS11200 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) EQM13_RS11220 ENOG4105CZ3 stage V sporulation protein ad EQM13_RS11225 ENOG41090VF Stage v sporulation protein ac EQM13_RS11240 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQM13_RS11245 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) EQM13_RS11265 ENOG4105CUZ uba thif-type nad fad binding protein EQM13_RS11305 ENOG4105EGD dinuclear metal center protein, YbgI family EQM13_RS11310 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) EQM13_RS11315 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQM13_RS11320 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) EQM13_RS11325 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein EQM13_RS11330 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) EQM13_RS11355 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) EQM13_RS11365 ENOG4105KG3 cytidine deaminase EQM13_RS11370 ENOG4108R5T secreted protein EQM13_RS11375 ENOG4107YR5 Diacylglycerol kinase EQM13_RS11385 ENOG4105CTJ Metal Dependent Phosphohydrolase EQM13_RS11390 ENOG4105C9A Phoh family EQM13_RS11400 ENOG41068P3 sporulation protein YqfC EQM13_RS11410 ENOG4105DI5 UPF0365 protein EQM13_RS11415 ENOG4105F7J membrane-bound serine protease EQM13_RS11420 ENOG4105KTH gatB Yqey EQM13_RS11430 ENOG4107YU2 histidine triad (hIT) protein EQM13_RS11435 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EQM13_RS11440 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) EQM13_RS11445 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) EQM13_RS11455 ENOG4105CFG Acts as a chaperone (By similarity) EQM13_RS11460 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ EQM13_RS11465 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) EQM13_RS11470 ENOG4105CSA Coproporphyrinogen iii oxidase EQM13_RS11475 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) EQM13_RS11485 ENOG4105C3F Signal peptidase i EQM13_RS11495 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) EQM13_RS11500 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) EQM13_RS11505 ENOG4105TQK DNA polymerase iii, delta' subunit EQM13_RS11510 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 EQM13_RS11515 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) EQM13_RS11525 ENOG4108RCM Nitroreductase EQM13_RS11540 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) EQM13_RS11550 ENOG4105BZG amino acid carrier protein EQM13_RS11565 ENOG4105BZ1 (ABC) transporter EQM13_RS11580 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EQM13_RS11610 ENOG4105BZU Histidine kinase EQM13_RS11620 ENOG4105EM7 Selenocysteine-specific translation elongation factor EQM13_RS11625 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) EQM13_RS11635 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein EQM13_RS11640 ENOG4105DZ1 carboxypeptidase EQM13_RS11645 ENOG4105KME endoribonuclease L-psp EQM13_RS11660 ENOG4108WF2 Metal Dependent Phosphohydrolase EQM13_RS11680 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control EQM13_RS11685 ENOG4105K46 50S ribosomal protein l27 EQM13_RS11700 ENOG4105C03 ribonuclease EQM13_RS11720 ENOG41083CN Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) EQM13_RS11725 ENOG4107QMS site-determining protein EQM13_RS11735 ENOG4107RF6 penicillin-binding protein EQM13_RS11750 ENOG4105DFF Rod shape-determining protein mreb EQM13_RS11755 ENOG4105W5Q DNA repair protein (RadC EQM13_RS11795 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) EQM13_RS11810 ENOG4105C19 ABC transporter EQM13_RS11815 ENOG4105EWM Histidine kinase EQM13_RS11820 ENOG4105CJZ response regulator EQM13_RS11840 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EQM13_RS11900 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) EQM13_RS11905 ENOG4105C2M dna polymerase I EQM13_RS11925 ENOG4105BZ1 (ABC) transporter EQM13_RS11945 ENOG4105DAS pts system EQM13_RS11950 ENOG4108RTU Aldolase EQM13_RS11965 ENOG4105D7N magnesium and cobalt transport protein CorA EQM13_RS12005 ENOG4105CJ1 ABC, transporter EQM13_RS12020 ENOG4105BZ1 (ABC) transporter EQM13_RS12025 ENOG4105BZ1 (ABC) transporter EQM13_RS12030 ENOG4105CAQ asparagine synthetase EQM13_RS12040 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EQM13_RS12050 ENOG4105DF9 Lipoate-protein, ligase EQM13_RS12055 ENOG4108IFG nitrite reductase, (NAD(P)H) EQM13_RS12060 ENOG4107RUE extracellular solute-binding protein family 1 EQM13_RS12065 ENOG4105D38 putrescine abc transporter EQM13_RS12070 ENOG4105F38 ABC transporter, permease EQM13_RS12075 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EQM13_RS12080 ENOG4108JCI Transcriptional regulator EQM13_RS12090 ENOG4108V0P LemA family EQM13_RS12105 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) EQM13_RS12110 ENOG4107QI6 Cysteine desulfurase EQM13_RS12115 ENOG4105HDK L-asparaginase EQM13_RS12135 ENOG4105CYC Transferase EQM13_RS12140 ENOG4105HKU nucleoside recognition domain-containing protein EQM13_RS12145 ENOG4105HKU nucleoside recognition domain-containing protein EQM13_RS12160 ENOG4105CIZ coA-substrate-specific enzyme activase EQM13_RS12325 ENOG4105DUM transcriptional regulator, lysR family EQM13_RS12330 ENOG4105DFM M18 family aminopeptidase EQM13_RS12335 ENOG4105WH1 Two component transcriptional regulator luxr family EQM13_RS12345 ENOG4108V3W Chemotaxis protein, CheW EQM13_RS12355 ENOG4105ETE Transcriptional regulator (LacI family EQM13_RS12360 ENOG4105BZU Histidine kinase EQM13_RS12365 ENOG41067TZ transcriptional regulator, MarR family EQM13_RS12370 ENOG4105CBD Diacylglycerol kinase EQM13_RS12380 ENOG4105BZ1 (ABC) transporter EQM13_RS12385 ENOG4105BZ1 (ABC) transporter EQM13_RS12390 ENOG4107RVV histidinol phosphate phosphatase, hisj family EQM13_RS12395 ENOG4108NGU Transcriptional regulator EQM13_RS12420 ENOG4105C28 cystathionine EQM13_RS12430 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) EQM13_RS12435 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EQM13_RS12450 ENOG4107U9W Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity) EQM13_RS12465 ENOG4105IU0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EQM13_RS12470 ENOG4105D22 carbon starvation protein EQM13_RS12485 ENOG4105EMS pseudouridine synthase EQM13_RS12490 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) EQM13_RS12495 ENOG4105DPN Oligoendopeptidase f EQM13_RS12500 ENOG4105CJN penicillin-binding protein EQM13_RS12510 ENOG4105HZM Fha domain containing protein EQM13_RS12520 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) EQM13_RS12535 ENOG4107X4V Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) EQM13_RS12565 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) EQM13_RS12605 ENOG4105CHJ isochorismatase hydrolase EQM13_RS12610 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EQM13_RS12620 ENOG4105C5H ABC transporter EQM13_RS12630 ENOG4105PTV Nudix Hydrolase EQM13_RS12655 ENOG4108IUW ABC transporter EQM13_RS12670 ENOG4105CJ1 ABC, transporter EQM13_RS12690 ENOG4108TYN CAAX amino terminal protease family protein EQM13_RS12735 ENOG4107Y80 Major Facilitator superfamily EQM13_RS12750 ENOG4105BZ1 (ABC) transporter EQM13_RS12810 ENOG4108NEV two component transcriptional regulator, LytTR family EQM13_RS12820 ENOG4107QIZ NADH dehydrogenase EQM13_RS12825 ENOG410902H NADH dehydrogenase (Ubiquinone), 24 kDa subunit EQM13_RS12830 ENOG4108K9K Uncharacterised protein family (UPF0236) EQM13_RS12835 ENOG4105E2V Glycosyltransferase 36 EQM13_RS12845 ENOG4105BZ1 (ABC) transporter EQM13_RS12850 ENOG4105BZ1 (ABC) transporter EQM13_RS12865 ENOG4105C1V Peptidase, M16 EQM13_RS12900 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) EQM13_RS12910 ENOG4105CVA phosphate EQM13_RS12920 ENOG4107VEG TrkA-N domain protein EQM13_RS12935 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) EQM13_RS12940 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) EQM13_RS12945 ENOG4105CPF Cell wall formation (By similarity) EQM13_RS12950 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) EQM13_RS12970 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) EQM13_RS12975 ENOG4105CP7 Triose-phosphate isomerase EQM13_RS12980 ENOG4105BZA Phosphoglycerate kinase EQM13_RS12995 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQM13_RS13015 ENOG4108ESE uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center EQM13_RS13020 ENOG4108Z0Z intracellular protease Pfpi family EQM13_RS13030 ENOG4105UIB (ABC) transporter EQM13_RS13035 ENOG4108JQ9 ABC transporter EQM13_RS13040 ENOG4107TFB basic membrane EQM13_RS13065 ENOG4105EZ5 reductase EQM13_RS13070 ENOG41080XV Thioredoxin EQM13_RS13085 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) EQM13_RS13090 ENOG410667J hydrolase EQM13_RS13095 ENOG4105E0A ABC, transporter EQM13_RS13100 ENOG4105EHG Permease protein EQM13_RS13105 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) EQM13_RS13120 ENOG41073R8 VanW family EQM13_RS13125 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) EQM13_RS13130 ENOG4105CSM endonuclease III EQM13_RS13140 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EQM13_RS13145 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) EQM13_RS13150 ENOG4105CNI cell division protein FtsW EQM13_RS13160 ENOG4105C5I Dehydrogenase EQM13_RS13195 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component EQM13_RS13210 ENOG4105TMB Formate nitrite transporter EQM13_RS13215 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) EQM13_RS13220 ENOG410908R Methenyltetrahydrofolate cyclohydrolase EQM13_RS13225 ENOG4105CKU formyltetrahydrofolate synthetase EQM13_RS13230 ENOG4105W4W Transcriptional regulator EQM13_RS13235 ENOG4108KHS signal transduction Histidine kinase EQM13_RS13245 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) EQM13_RS13255 ENOG4105C28 cystathionine EQM13_RS13260 ENOG4105C59 p-type ATPase EQM13_RS13265 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase EQM13_RS13270 ENOG4105C4R Atp-dependent dna helicase EQM13_RS13285 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 EQM13_RS13310 ENOG4105EPR degv family EQM13_RS13325 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) EQM13_RS13335 ENOG4105CM2 brancheD-chain amino acid aminotransferase EQM13_RS13345 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) EQM13_RS13350 ENOG4105CI3 gtp-binding protein typa EQM13_RS13360 ENOG4105BZ1 (ABC) transporter EQM13_RS13385 ENOG4105C4X radical SAM domain protein EQM13_RS13400 ENOG4108IV0 ABC, transporter EQM13_RS13405 ENOG4105C0Z ABC transporter EQM13_RS13410 ENOG4105CF8 branched-chain amino acid ABC transporter, permease EQM13_RS13415 ENOG4105C32 Amino acid ABC transporter (Permease) EQM13_RS13420 ENOG4105CP9 extracellular ligand-binding receptor EQM13_RS13435 ENOG4105DG6 mannose-6-phosphate isomerase EQM13_RS13440 ENOG4105DG6 mannose-6-phosphate isomerase EQM13_RS13445 ENOG4105F3R pts system mannose fructose sorbose family iid EQM13_RS13450 ENOG4108IQ3 PTS system EQM13_RS13460 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism EQM13_RS13480 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) EQM13_RS13485 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) EQM13_RS13490 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) EQM13_RS13495 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EQM13_RS13500 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation EQM13_RS13515 ENOG4108JQ7 (ABC) transporter EQM13_RS13520 ENOG4105C3U ABC transporter EQM13_RS13525 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EQM13_RS13535 ENOG4105DEF Extracellular solute-binding protein, family 5 EQM13_RS13555 ENOG4108RAC Rubrerythrin EQM13_RS13560 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase EQM13_RS13580 ENOG4105D9U N-acetyltransferase EQM13_RS13595 ENOG4105C02 permease EQM13_RS13600 ENOG4105EC8 Methyl-accepting chemotaxis EQM13_RS13720 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) EQM13_RS13795 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) EQM13_RS13815 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) EQM13_RS13820 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) EQM13_RS13825 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate EQM13_RS13830 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EQM13_RS13835 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EQM13_RS13840 ENOG4105CHR reductase EQM13_RS13845 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase EQM13_RS13850 ENOG4105EA8 2-Nitropropane dioxygenase EQM13_RS13855 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) EQM13_RS13865 ENOG4105CE4 GlcNAc 6-P deacetylase EQM13_RS13875 ENOG4105F3R pts system mannose fructose sorbose family iid EQM13_RS13880 ENOG4105ETZ PTS System EQM13_RS13885 ENOG4108UZY PTS System EQM13_RS13890 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EQM13_RS13900 ENOG4105C6T cysteine synthase EQM13_RS13915 ENOG4105CEM UPF0597 protein EQM13_RS13940 ENOG4105D1F ATP-binding protein EQM13_RS13945 ENOG4105CKM Branched-chain carboxylic acid kinase EQM13_RS13950 ENOG4107RE7 phosphate butyryltransferase EQM13_RS13955 ENOG4105CKM Branched-chain carboxylic acid kinase EQM13_RS13965 ENOG4105C8B TIGR00159 family EQM13_RS13985 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) EQM13_RS13990 ENOG4105KRI phosphocarrier protein (HPr EQM13_RS14010 ENOG4105D9Q decarboxylase (Beta subunit) EQM13_RS14015 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) EQM13_RS14030 ENOG410787A Pts system, glucitol sorbitol-specific EQM13_RS14035 ENOG4105DZY Pts system, glucitol sorbitol-specific EQM13_RS14050 ENOG4105D2N Aldolase EQM13_RS14115 ENOG4105CPQ Dehydrogenase EQM13_RS14120 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EQM13_RS14125 ENOG4108JQ1 Dehydrogenase EQM13_RS14130 ENOG4105F3R pts system mannose fructose sorbose family iid EQM13_RS14140 ENOG4105KPI PTS system sorbose subfamily IIB component EQM13_RS14150 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EQM13_RS14165 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b EQM13_RS14170 ENOG4105BZ1 (ABC) transporter EQM13_RS14175 ENOG4105BZ1 (ABC) transporter EQM13_RS14200 ENOG4105Y5S NADH ubiquinone oxidoreductase, 24 kD EQM13_RS14205 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EQM13_RS14210 ENOG4105CKI cobalamin synthesis protein EQM13_RS14230 ENOG4108UJD 30S ribosomal protein S9 EQM13_RS14240 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) EQM13_RS14245 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) EQM13_RS14250 ENOG4108JJB ABC transporter EQM13_RS14255 ENOG4108JJB ABC transporter EQM13_RS14260 ENOG4108ZT0 50S ribosomal protein l17 EQM13_RS14265 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EQM13_RS14270 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) EQM13_RS14275 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) EQM13_RS14280 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits EQM13_RS14285 ENOG41067V7 50S ribosomal protein L36 EQM13_RS14305 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) EQM13_RS14310 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) EQM13_RS14315 ENOG4105VPB 50S ribosomal protein L30 EQM13_RS14320 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) EQM13_RS14325 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) EQM13_RS14330 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) EQM13_RS14335 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) EQM13_RS14340 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) EQM13_RS14350 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) EQM13_RS14360 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal EQM13_RS14365 ENOG41082SA 50s ribosomal protein l29 EQM13_RS14370 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) EQM13_RS14375 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) EQM13_RS14380 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) EQM13_RS14385 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) EQM13_RS14395 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) EQM13_RS14400 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) EQM13_RS14415 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) EQM13_RS14425 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) EQM13_RS14430 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) EQM13_RS14435 ENOG4105XPM ribosomal protein EQM13_RS14440 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EQM13_RS14445 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EQM13_RS14455 ENOG4108VZM 50s ribosomal protein L10 EQM13_RS14470 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) EQM13_RS14475 ENOG410683Z Preprotein translocase SecE subunit EQM13_RS14480 ENOG4105WDJ 50S ribosomal protein L33 EQM13_RS14485 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) EQM13_RS14495 ENOG4105QIV RNA polymerase EQM13_RS14500 ENOG4105M0M Tetracycline resistance protein EQM13_RS14505 ENOG4105C2N RNA methyltransferase TrmH family group 3 EQM13_RS14510 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) EQM13_RS14515 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) EQM13_RS14525 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) EQM13_RS14535 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) EQM13_RS14545 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) EQM13_RS14550 ENOG4105CTP PilT protein domain protein EQM13_RS14555 ENOG4108VJ1 Transcriptional regulator (CarD family EQM13_RS14570 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) EQM13_RS14575 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EQM13_RS14580 ENOG41066A3 ATP guanido phosphotransferase EQM13_RS14585 ENOG4108Z0C Uvrb UvrC protein EQM13_RS14590 ENOG4105KEX transcriptional regulator, ctsr EQM13_RS14595 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) EQM13_RS14600 ENOG4105CIH Imidazole acetol-phosphate transaminase EQM13_RS14605 ENOG4108IV0 ABC, transporter EQM13_RS14610 ENOG4105C0Z ABC transporter EQM13_RS14615 ENOG4105CF8 branched-chain amino acid ABC transporter, permease EQM13_RS14620 ENOG4105C32 Amino acid ABC transporter (Permease) EQM13_RS14625 ENOG4105CP9 extracellular ligand-binding receptor EQM13_RS14645 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) EQM13_RS14650 ENOG4107QN2 dihydrolipoyl dehydrogenase EQM13_RS14655 ENOG4105C7S Dehydrogenase EQM13_RS14660 ENOG4105CPP Dehydrogenase, E1 component EQM13_RS14665 ENOG4107RUY (E1 component), alpha subunit EQM13_RS14680 ENOG4105DZY Pts system, glucitol sorbitol-specific EQM13_RS14685 ENOG410787A Pts system, glucitol sorbitol-specific EQM13_RS14690 ENOG4105J92 DNA-binding transcriptional activator GutM EQM13_RS14695 ENOG4107RHR regulatoR EQM13_RS14700 ENOG410667J hydrolase EQM13_RS14705 ENOG4105CBX hi0933 family EQM13_RS14710 ENOG4108KR4 dihydrodipicolinate reductase EQM13_RS14715 ENOG4108Z5V transcriptional regulator, merr family EQM13_RS14755 ENOG4108UN4 phage SPO1 DNA polymerase-related protein EQM13_RS14760 ENOG4108UN4 phage SPO1 DNA polymerase-related protein EQM13_RS14765 ENOG4105CRK lysyL-tRNA synthetase EQM13_RS14770 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) EQM13_RS14780 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) EQM13_RS14785 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) EQM13_RS14795 ENOG4105KXX peptidase s58 dmpa EQM13_RS14800 ENOG4105D9Q decarboxylase (Beta subunit) EQM13_RS14805 ENOG4105PV1 biotin lipoyl attachment domaiN-containing protein EQM13_RS14820 ENOG4108ZVT methylmalonyl-coA epimerase EQM13_RS14840 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EQM13_RS14850 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) EQM13_RS14855 ENOG4105D9P serine threonine protein kinase EQM13_RS14880 ENOG4105BZU Histidine kinase EQM13_RS14885 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EQM13_RS14890 ENOG4105G3A stage ii sporulation protein e EQM13_RS14895 ENOG41060GV RNA binding s1 domain protein EQM13_RS14910 ENOG4105VYY sporulation protein yabp EQM13_RS14915 ENOG41082I2 s4 domain protein EQM13_RS14920 ENOG4105K70 DNA-binding protein EQM13_RS14925 ENOG4108IY2 MazG family EQM13_RS14935 ENOG4108M14 stage v sporulation protein t EQM13_RS14940 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) EQM13_RS14945 ENOG4108JA2 transcriptioN-repair coupling factor EQM13_RS14955 ENOG4105C5T Phosphoribosyl pyrophosphate synthase EQM13_RS14970 ENOG4105DFT pur operon repressor EQM13_RS14975 ENOG4105DFU Cell wall formation (By similarity) EQM13_RS14980 ENOG4108KGH TRANSCRIPTIONal EQM13_RS14985 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EQM13_RS14990 ENOG4105E39 Enoyl-CoA hydratase EQM13_RS15000 ENOG4107QYV phosphohexose isomerase EQM13_RS15020 ENOG4105C8Q Methyl-accepting chemotaxis EQM13_RS15030 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) EQM13_RS15035 ENOG4108YZ8 Superoxide reductase EQM13_RS15040 ENOG4105CYC Transferase EQM13_RS15045 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) EQM13_RS15050 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) EQM13_RS15055 ENOG4105K4I Scp-like extracellular EQM13_RS15060 ENOG4105P8F nudix hydrolase EQM13_RS15080 ENOG4105E4R Precorrin-3B C17-methyltransferase EQM13_RS15085 ENOG4105CIH Imidazole acetol-phosphate transaminase EQM13_RS15095 ENOG4105D78 K07001 NTE family protein EQM13_RS15105 ENOG4108IGT Dipeptidase EQM13_RS15120 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EQM13_RS15130 ENOG4105EMU Dehydrogenase EQM13_RS15135 ENOG4108UHU Aldolase EQM13_RS15140 ENOG4105C5I Dehydrogenase EQM13_RS15150 ENOG4105CE4 GlcNAc 6-P deacetylase EQM13_RS15165 ENOG4105CK5 oxidoreductase EQM13_RS15170 ENOG4108SU4 UPF0309 protein EQM13_RS15175 ENOG4105DAS pts system EQM13_RS15180 ENOG4105F3R pts system mannose fructose sorbose family iid EQM13_RS15195 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EQM13_RS15200 ENOG4105FDP GntR family transcriptional regulator EQM13_RS15215 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) EQM13_RS15220 ENOG4105F3R pts system mannose fructose sorbose family iid EQM13_RS15225 ENOG4105ETZ PTS System EQM13_RS15230 ENOG4108UZY PTS System EQM13_RS15235 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) EQM13_RS15240 ENOG4105DJV ribulose-phosphate 3-epimerase EQM13_RS15245 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) EQM13_RS15255 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) EQM13_RS15260 ENOG4105DM4 PTS System EQM13_RS15265 ENOG4108X4Q Hydrolase EQM13_RS15275 ENOG4105F1A Pyruvate formate-lyase EQM13_RS15280 ENOG4105C6N Formate acetyltransferase EQM13_RS15320 ENOG4107QMH DNA methylase EQM13_RS15345 ENOG4105C7Z Conserved Protein EQM13_RS15370 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EQM13_RS15375 ENOG4105BZU Histidine kinase EQM13_RS15390 ENOG4105FGV Chromate EQM13_RS15395 ENOG4105X1N Glycosyl transferase family 8 EQM13_RS15420 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) EQM13_RS15425 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EQM13_RS15445 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) EQM13_RS15475 ENOG4105BZ1 (ABC) transporter EQM13_RS15480 ENOG4105BZ1 (ABC) transporter EQM13_RS15500 ENOG4105DEU major facilitator superfamily EQM13_RS15505 ENOG4105D70 Integrase catalytic subunit EQM13_RS15510 ENOG4105F5W AtP-binding protein EQM13_RS15535 ENOG4105BZ1 (ABC) transporter EQM13_RS15545 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) EQM13_RS15625 ENOG4108Q52 Methyltransferase cognate corrinoid protein EQM13_RS15630 ENOG4107RBB ABC transporter, permease EQM13_RS15640 ENOG4105BZU Histidine kinase EQM13_RS15675 ENOG4105II7 pyrroline-5-carboxylate reductase EQM13_RS15680 ENOG4105DC7 peptidase M24 EQM13_RS15690 ENOG4105JVQ RNA Polymerase EQM13_RS15710 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EQM13_RS15720 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) EQM13_RS15740 ENOG4105R8C Transcriptional regulator EQM13_RS15795 ENOG4106N3A copper homeostasis protein cutc EQM13_RS15805 ENOG4105C5Y PTS System EQM13_RS15820 ENOG4105C5Y PTS System EQM13_RS15825 ENOG4105CID antiterminator EQM13_RS15830 ENOG4105CI1 PTS System EQM13_RS15840 ENOG4105CJ1 ABC, transporter EQM13_RS15900 ENOG41067QW Transcriptional regulator EQM13_RS15955 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) EQM13_RS15960 ENOG41067QW Transcriptional regulator EQM13_RS16000 ENOG4108C33 Resolvase EQM13_RS16045 ENOG4107TXC Transcriptional regulator EQM13_RS16055 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) EQM13_RS16080 ENOG4105DZR Type I site-specific deoxyribonuclease EQM13_RS16090 ENOG4105EKX Restriction modification system DNA (Specificity EQM13_RS16095 ENOG4105CVR type I restriction-modification system EQM13_RS16105 ENOG4107V6I Cytosine-specific methyltransferase EQM13_RS16110 ENOG4105PZN Type II restriction enzyme NlaIV EQM13_RS16155 ENOG4105C2M dna polymerase I EQM13_RS16210 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP EQM13_RS16255 ENOG4105CAR Terminase, large subunit EQM13_RS16265 ENOG4105EFC phage portal protein HK97 family EQM13_RS16270 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EQM13_RS16340 ENOG4105XSJ toxin secretion phage lysis holin EQM13_RS16370 ENOG4105DQ6 Transposase EQM13_RS16375 ENOG4105EKQ RNA-directed DNA polymerase EQM13_RS16405 ENOG4105CVR type I restriction-modification system EQM13_RS16415 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) EQM13_RS16425 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EQM13_RS16435 ENOG4107SQC 5-methylcytosine-specific restriction enzyme subunit McrC EQM13_RS16440 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 EQM13_RS16455 ENOG4105DVT helicase EQM13_RS16475 ENOG4108SU4 UPF0309 protein EQM13_RS16490 ENOG4105F3R pts system mannose fructose sorbose family iid EQM13_RS16495 ENOG4105ETZ PTS System EQM13_RS16500 ENOG4105DAS pts system EQM13_RS16515 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EQM13_RS16520 ENOG4105PUK Membrane EQM13_RS16530 ENOG4105YPM F pilin acetylation protein TraX EQM13_RS16550 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase EQM13_RS16560 ENOG4108JQ7 (ABC) transporter EQM13_RS16570 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EQM13_RS16575 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EQM13_RS16605 ENOG4105CZV ABC transporter EQM13_RS16610 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family EQM13_RS16620 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EQM13_RS16695 ENOG4105C7R Atpase associated with various cellular activities aaa_3 EQM13_RS16720 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase EQM13_RS16760 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) EQM13_RS16765 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EQM13_RS16775 ENOG4106V2I dimethylaminohydrolase EQM13_RS16795 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EQM13_RS16830 ENOG4105CJ1 ABC, transporter EQM13_RS16835 ENOG4105BZ1 (ABC) transporter EQM13_RS16845 ENOG4105BZ1 (ABC) transporter EQM13_RS16860 ENOG4105DA5 (ABC) transporter EQM13_RS16875 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EQM13_RS16895 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) EQM13_RS16900 ENOG4108VX5 3-methyladenine DNA glycosylase EQM13_RS16920 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B EQM13_RS16930 ENOG4105C26 Dehydrogenase EQM13_RS16950 ENOG4105DZY Pts system, glucitol sorbitol-specific EQM13_RS16960 ENOG410787A Pts system, glucitol sorbitol-specific EQM13_RS16975 ENOG4105CHR reductase EQM13_RS17000 ENOG41068JE domain protein EQM13_RS17010 ENOG4105DFD Na H antiporter EQM13_RS17015 ENOG4105N5T Radical SAM Protein EQM13_RS17025 ENOG4105CPQ Dehydrogenase EQM13_RS17030 ENOG4107QW4 alcohol dehydrogenase EQM13_RS17045 ENOG4108PJD permease EQM13_RS17060 ENOG4105FAV ABC, transporter EQM13_RS17065 ENOG4105FDK ABC transporter EQM13_RS17070 ENOG4105DSE periplasmic solute binding protein EQM13_RS17090 ENOG4105C1J atp-dependent rna helicase EQM13_RS17095 ENOG4105PXI polysaccharide deacetylase EQM13_RS17125 ENOG4105JVQ RNA Polymerase EQM13_RS17145 ENOG4108Z66 YbaK ebsC protein EQM13_RS17165 ENOG4108K9K Uncharacterised protein family (UPF0236) EQM13_RS17200 ENOG4105DA5 (ABC) transporter EQM13_RS17235 ENOG4105EMN RNA polymerase sigma factor EQM13_RS17245 ENOG410841Q phosphoesterase PA-phosphatase related protein EQM13_RS17250 ENOG4107T5V SNARE associated Golgi EQM13_RS17255 ENOG4105EEX Two component transcriptional regulator (Winged helix family EQM13_RS17320 ENOG4105C19 ABC transporter EQM13_RS17325 ENOG4105BZU Histidine kinase EQM13_RS17330 ENOG4108KXV response regulator EQM13_RS17350 ENOG41065SU Two-component system sensor kinase EQM13_RS17355 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EQM13_RS17360 ENOG4105C4R Atp-dependent dna helicase EQM13_RS17430 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EQM13_RS17440 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) EQM13_RS17460 ENOG4108TVJ Nitroreductase EQM13_RS17470 ENOG4105C5H ABC transporter EQM13_RS17475 ENOG4105ER2 Ompa motb domain protein EQM13_RS17480 ENOG4107R0U MotA TolQ exbB proton channel EQM13_RS17485 ENOG4105C5H ABC transporter EQM13_RS17495 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein EQM13_RS17500 ENOG4105DE4 1-phosphofructokinase EQM13_RS17510 ENOG4105ETD TRANSCRIPTIONal EQM13_RS17515 ENOG4105CTS PTS system mannitol-specific EQM13_RS17530 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein EQM13_RS17545 ENOG4108SU4 UPF0309 protein EQM13_RS17550 ENOG4107XJU UPF0178 protein EQM13_RS17555 ENOG4105C9U ATP-dependent DNA helicase RecQ EQM13_RS17570 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) EQM13_RS17585 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EQM13_RS17590 ENOG4105GR3 Histidine kinase EQM13_RS17595 ENOG4108UTW Plays a role in the regulation of phosphate uptake EQM13_RS17600 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EQM13_RS17610 ENOG4105C8U phosphate abc transporter EQM13_RS17615 ENOG4105CVA phosphate EQM13_RS17630 ENOG4108SDH ABC, transporter EQM13_RS17635 ENOG4108IUW ABC transporter EQM13_RS17645 ENOG4108UT2 hemolysin iii EQM13_RS17655 ENOG4105CGK Exodeoxyribonuclease III EQM13_RS17660 ENOG4105F9U Dehydrogenase EQM13_RS17670 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) EQM13_RS17675 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) EQM13_RS17685 ENOG4105C2N RNA methyltransferase TrmH family group 3 EQM13_RS17690 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) EQM13_RS17735 ENOG4105DC7 peptidase M24 EQM13_RS17740 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EQM13_RS17750 ENOG4108JQ7 (ABC) transporter EQM13_RS17800 ENOG4105Q2H domain protein EQM13_RS17825 ENOG4105BZU Histidine kinase EQM13_RS17845 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EQM13_RS17850 ENOG4105DR5 peptidase EQM13_RS17870 ENOG4108ZDA Sporulation protein YyaC EQM13_RS17880 ENOG4105CBD Diacylglycerol kinase EQM13_RS17895 ENOG4105CPN adenine deaminase EQM13_RS17920 ENOG4108SER Transposase EQM13_RS17925 ENOG4105DQ6 Transposase EQM13_RS17930 ENOG4105EKQ RNA-directed DNA polymerase EQM13_RS17990 ENOG4105DA5 (ABC) transporter EQM13_RS17995 ENOG4107QHI -hydrogenase EQM13_RS18000 ENOG4107QIZ NADH dehydrogenase EQM13_RS18010 ENOG410902H NADH dehydrogenase (Ubiquinone), 24 kDa subunit EQM13_RS18015 ENOG4105JAB phenazine biosynthesis protein, phzf family EQM13_RS18020 ENOG4105FA0 parb-like partition protein EQM13_RS18025 ENOG4107QJE Chromosome Partitioning Protein EQM13_RS18035 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) EQM13_RS18040 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) EQM13_RS18045 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) EQM13_RS18050 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein EQM13_RS18055 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins EQM13_RS18060 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) EQM13_RS18065 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) EQM13_RS18070 ENOG4105VG0 50S ribosomal protein l34 EQM13_RS18330 ENOG4105BZ1 (ABC) transporter EQM13_RS18385 ENOG410801F ribosomal-protein-alanine acetyltransferase EQM13_RS18405 ENOG4105K4H Nlp p60 protein