locus-tag	class	description
TMO_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TMO_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TMO_RS00035	COG3384	dioxygenase
TMO_RS00040	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TMO_RS00045	COG2814	Major facilitator Superfamily
TMO_RS00050	COG0372	Belongs to the citrate synthase family
TMO_RS00055	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
TMO_RS00080	COG1177	transmembrane transport
TMO_RS00085	COG1176	ABC-type spermidine putrescine transport system, permease component I
TMO_RS00090	COG3842	ATPase activity
TMO_RS00100	COG0842	Transport permease protein
TMO_RS00105	COG1131	(ABC) transporter
TMO_RS00120	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
TMO_RS00135	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TMO_RS00155	COG1414	Transcriptional regulator
TMO_RS00185	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_RS00325	COG3620	sequence-specific DNA binding
TMO_RS00420	COG0114	fumarate hydratase activity
TMO_RS00440	COG0181	hydroxymethylbilane synthase activity
TMO_RS00445	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TMO_RS00475	COG2350	Protein conserved in bacteria
TMO_RS00490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TMO_RS00520	COG5508	conserved small protein
TMO_RS00550	COG0719	Fe-S assembly protein
TMO_RS00555	COG0396	ATPase activity
TMO_RS00560	COG0719	Fe-S assembly protein
TMO_RS00565	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TMO_RS00575	COG2151	metal-sulfur cluster biosynthetic enzyme
TMO_RS00615	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TMO_RS00615	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TMO_RS00620	COG0604	alcohol dehydrogenase
TMO_RS00640	COG2086	electron transfer activity
TMO_RS00650	COG1250	3-hydroxyacyl-CoA dehydrogenase
TMO_RS00655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TMO_RS00660	COG0165	Argininosuccinate lyase
TMO_RS00670	COG0019	diaminopimelate decarboxylase activity
TMO_RS00685	COG2884	Cell division ATP-binding protein ftsE
TMO_RS00725	COG0287	Prephenate dehydrogenase
TMO_RS00740	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TMO_RS00745	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TMO_RS00745	COG2813	Specifically methylates the guanine in position
TMO_RS00750	COG2205	protein histidine kinase activity
TMO_RS00750	COG2202	Pas domain
TMO_RS00755	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TMO_RS00760	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TMO_RS00775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TMO_RS00780	COG0625	glutathione transferase activity
TMO_RS00835	COG4120	Belongs to the binding-protein-dependent transport system permease family
TMO_RS00855	COG2917	probably involved in intracellular septation
TMO_RS00860	COG0552	protein localization to endoplasmic reticulum
TMO_RS00865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TMO_RS00870	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TMO_RS00875	COG2205	protein histidine kinase activity
TMO_RS00880	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TMO_RS00890	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
TMO_RS00890	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TMO_RS00895	COG1660	Displays ATPase and GTPase activities
TMO_RS00900	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TMO_RS00905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TMO_RS00910	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TMO_RS00915	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TMO_RS00920	COG1137	ATPase activity
TMO_RS00940	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
TMO_RS00960	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TMO_RS00975	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TMO_RS00985	COG0488	(ABC) transporter
TMO_RS01000	COG0859	PFAM glycosyl transferase family 9
TMO_RS01005	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TMO_RS01010	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TMO_RS01015	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TMO_RS01020	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TMO_RS01055	COG0640	Transcriptional regulator
TMO_RS01060	COG0288	reversible hydration of carbon dioxide
TMO_RS01110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TMO_RS01115	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TMO_RS01120	COG1522	sequence-specific DNA binding
TMO_RS01145	COG2814	Major facilitator Superfamily
TMO_RS01150	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_RS01165	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_RS01180	COG0840	transmembrane signaling receptor activity
TMO_RS01185	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TMO_RS01190	COG0583	DNA-binding transcription factor activity
TMO_RS01215	COG0412	Dienelactone hydrolase
TMO_RS01220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TMO_RS01250	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TMO_RS01265	COG0583	DNA-binding transcription factor activity
TMO_RS01275	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TMO_RS01285	COG1846	Transcriptional regulator
TMO_RS01290	COG2267	carboxylic ester hydrolase activity
TMO_RS01305	COG2832	Protein of unknown function (DUF454)
TMO_RS01310	COG0753	catalase activity
TMO_RS01320	COG2814	Major facilitator Superfamily
TMO_RS01335	COG1230	cation diffusion facilitator family transporter
TMO_RS01345	COG0583	DNA-binding transcription factor activity
TMO_RS01385	COG0747	negative chemotaxis
TMO_RS01390	COG0601	transmembrane transport
TMO_RS01395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TMO_RS01400	COG4172	Belongs to the ABC transporter superfamily
TMO_RS01405	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TMO_RS01415	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TMO_RS01420	COG2244	polysaccharide biosynthetic process
TMO_RS01450	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TMO_RS01465	COG1024	Enoyl-CoA hydratase
TMO_RS01475	COG1177	transmembrane transport
TMO_RS01485	COG3842	ATPase activity
TMO_RS01495	COG0174	glutamine synthetase
TMO_RS01505	COG4608	Belongs to the ABC transporter superfamily
TMO_RS01515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TMO_RS01530	COG3191	aminopeptidase activity
TMO_RS01560	COG0412	Dienelactone hydrolase
TMO_RS01575	COG0012	GTP binding
TMO_RS01580	COG0193	aminoacyl-tRNA hydrolase activity
TMO_RS01585	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TMO_RS01590	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TMO_RS01600	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
TMO_RS01630	COG0640	Transcriptional regulator
TMO_RS01635	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TMO_RS01640	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
TMO_RS01645	COG3604	Transcriptional regulator
TMO_RS01650	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TMO_RS01650	COG1116	anion transmembrane transporter activity
TMO_RS01660	COG1116	anion transmembrane transporter activity
TMO_RS01665	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
TMO_RS01690	COG1137	ATPase activity
TMO_RS01700	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
TMO_RS01705	COG1396	sequence-specific DNA binding
TMO_RS01710	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
TMO_RS01730	COG1396	sequence-specific DNA binding
TMO_RS01755	COG4536	flavin adenine dinucleotide binding
TMO_RS01760	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TMO_RS01765	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TMO_RS01775	COG4974	Belongs to the 'phage' integrase family
TMO_RS01785	COG2301	Belongs to the HpcH HpaI aldolase family
TMO_RS01805	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TMO_RS01810	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TMO_RS01815	COG0494	nUDIX hydrolase
TMO_RS01820	COG2226	methyltransferase
TMO_RS01835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TMO_RS01840	COG1346	cytolysis
TMO_RS01845	COG1380	Effector of murein hydrolase LrgA
TMO_RS01850	COG0583	DNA-binding transcription factor activity
TMO_RS01855	COG2814	Major facilitator Superfamily
TMO_RS01900	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TMO_RS01905	COG0527	aspartate kinase activity
TMO_RS01910	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
TMO_RS01920	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TMO_RS01925	COG0124	histidyl-tRNA synthetase
TMO_RS01930	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TMO_RS01935	COG2890	protein-(glutamine-N5) methyltransferase activity
TMO_RS01950	COG0542	response to heat
TMO_RS01955	COG0739	heme binding
TMO_RS01990	COG1349	DNA-binding transcription factor activity
TMO_RS01995	COG2132	Multicopper oxidase
TMO_RS02005	COG4774	siderophore transport
TMO_RS02020	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TMO_RS02025	COG0583	DNA-binding transcription factor activity
TMO_RS02030	COG0583	DNA-binding transcription factor activity
TMO_RS02040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TMO_RS02050	COG2358	TRAP transporter, solute receptor (TAXI family
TMO_RS02060	COG0842	Transport permease protein
TMO_RS02075	COG0386	Belongs to the glutathione peroxidase family
TMO_RS02085	COG0123	including yeast histone deacetylase and acetoin utilization protein
TMO_RS02110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TMO_RS02115	COG0667	Aldo Keto reductase
TMO_RS02120	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TMO_RS02125	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TMO_RS02130	COG0583	DNA-binding transcription factor activity
TMO_RS02140	COG3002	Belongs to the UPF0753 family
TMO_RS02150	COG1609	Transcriptional regulator
TMO_RS02155	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
TMO_RS02155	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TMO_RS02160	COG1105	Belongs to the carbohydrate kinase PfkB family
TMO_RS02165	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TMO_RS02165	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TMO_RS02170	COG1335	isochorismatase
TMO_RS02175	COG4774	siderophore transport
TMO_RS02185	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TMO_RS02190	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TMO_RS02210	COG0243	molybdopterin cofactor binding
TMO_RS02215	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_RS02225	COG3842	ATPase activity
TMO_RS02245	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TMO_RS02255	COG3047	cAMP biosynthetic process
TMO_RS02260	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TMO_RS02280	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TMO_RS02285	COG0457	Tetratricopeptide repeat
TMO_RS02295	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TMO_RS02310	COG2205	protein histidine kinase activity
TMO_RS02335	COG0583	DNA-binding transcription factor activity
TMO_RS02365	COG2186	Transcriptional regulator
TMO_RS02370	COG1304	FMN binding
TMO_RS02430	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_RS02450	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TMO_RS02475	COG1024	Enoyl-CoA hydratase
TMO_RS02485	COG1032	radical SAM domain protein
TMO_RS02495	COG3321	synthase
TMO_RS02495	COG0604	alcohol dehydrogenase
TMO_RS02495	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_RS02540	COG0410	ABC transporter
TMO_RS02575	COG3932	Exopolysaccharide synthesis, ExoD
TMO_RS02600	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
TMO_RS02605	COG2205	protein histidine kinase activity
TMO_RS02610	COG1960	acyl-CoA dehydrogenase activity
TMO_RS02630	COG2814	Major facilitator Superfamily
TMO_RS02640	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TMO_RS02645	COG0400	carboxylic ester hydrolase activity
TMO_RS02660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TMO_RS02665	COG1309	transcriptional regulator
TMO_RS02670	COG1960	acyl-CoA dehydrogenase activity
TMO_RS02680	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
TMO_RS02685	COG0523	cobalamin synthesis protein
TMO_RS02705	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TMO_RS02715	COG2124	cytochrome p450
TMO_RS02725	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TMO_RS02740	COG0456	acetyltransferase
TMO_RS02745	COG0183	Belongs to the thiolase family
TMO_RS02755	COG0589	response to stress
TMO_RS02770	COG3485	protocatechuate 3,4-dioxygenase
TMO_RS02775	COG2207	Transcriptional regulator
TMO_RS02790	COG1454	alcohol dehydrogenase
TMO_RS02800	COG0824	Thioesterase
TMO_RS02805	COG2983	Belongs to the UPF0260 family
TMO_RS02810	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_RS02825	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TMO_RS02830	COG0022	dehydrogenase e1 component
TMO_RS02835	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TMO_RS02840	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TMO_RS02850	COG0028	Belongs to the TPP enzyme family
TMO_RS02860	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TMO_RS02880	COG1525	nuclease
TMO_RS02885	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
TMO_RS02890	COG2166	iron-sulfur cluster assembly
TMO_RS02895	COG0235	Class ii aldolase
TMO_RS02905	COG0154	amidase activity
TMO_RS02920	COG3396	Phenylacetate-CoA oxygenase
TMO_RS02925	COG1192	Involved in chromosome partitioning
TMO_RS02940	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TMO_RS02945	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TMO_RS02955	COG0861	Integral membrane protein TerC family
TMO_RS02960	COG2203	Gaf domain
TMO_RS02960	COG0840	transmembrane signaling receptor activity
TMO_RS02965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TMO_RS02970	COG1686	Belongs to the peptidase S11 family
TMO_RS03055	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_RS03060	COG0501	Belongs to the peptidase M48B family
TMO_RS03070	COG0028	Belongs to the TPP enzyme family
TMO_RS03080	COG1012	belongs to the aldehyde dehydrogenase family
TMO_RS03085	COG1902	pentaerythritol trinitrate reductase activity
TMO_RS03110	COG2271	Major facilitator Superfamily
TMO_RS03130	COG4106	trans-aconitate 2-methyltransferase activity
TMO_RS03135	COG2814	Major facilitator Superfamily
TMO_RS03145	COG0840	transmembrane signaling receptor activity
TMO_RS03165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TMO_RS03195	COG1250	3-hydroxyacyl-CoA dehydrogenase
TMO_RS03200	COG1960	acyl-CoA dehydrogenase activity
TMO_RS03205	COG1960	acyl-CoA dehydrogenase activity
TMO_RS03210	COG1960	acyl-CoA dehydrogenase activity
TMO_RS03215	COG1024	Enoyl-CoA hydratase
TMO_RS03215	COG1250	3-hydroxyacyl-CoA dehydrogenase
TMO_RS03250	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_RS03260	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_RS03265	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_RS03285	COG1960	acyl-CoA dehydrogenase activity
TMO_RS03295	COG3321	synthase
TMO_RS03295	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_RS03295	COG0604	alcohol dehydrogenase
TMO_RS03300	COG0840	transmembrane signaling receptor activity
TMO_RS03335	COG3186	Phenylalanine-4-hydroxylase
TMO_RS03365	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
TMO_RS03415	COG0402	S-adenosylhomocysteine deaminase activity
TMO_RS03420	COG1079	Belongs to the binding-protein-dependent transport system permease family
TMO_RS03425	COG4603	Belongs to the binding-protein-dependent transport system permease family
TMO_RS03430	COG3845	ABC transporter
TMO_RS03445	COG0586	Pfam SNARE associated Golgi protein
TMO_RS03455	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TMO_RS03455	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TMO_RS03470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TMO_RS03500	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_RS03515	COG2030	dehydratase
TMO_RS03520	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TMO_RS03525	COG1846	Transcriptional regulator
TMO_RS03530	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_RS03535	COG1960	acyl-CoA dehydrogenase activity
TMO_RS03545	COG1024	Enoyl-CoA hydratase
TMO_RS03565	COG4208	sulfate ABC transporter
TMO_RS03570	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
TMO_RS03585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TMO_RS03610	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TMO_RS03640	COG3335	DDE superfamily endonuclease
TMO_RS03645	COG3415	Transposase
TMO_RS03665	COG2824	Alkylphosphonate utilization operon protein PhnA
TMO_RS03675	COG1309	transcriptional regulator
TMO_RS03680	COG2311	Membrane
TMO_RS03690	COG1695	Transcriptional regulator
TMO_RS03700	COG2814	Major facilitator Superfamily
TMO_RS03705	COG0583	DNA-binding transcription factor activity
TMO_RS03715	COG5507	3-demethylubiquinone-9 3-methyltransferase
TMO_RS03730	COG1846	Transcriptional regulator
TMO_RS03735	COG0697	spore germination
TMO_RS03740	COG2130	NADP-dependent
TMO_RS03750	COG2423	ornithine cyclodeaminase activity
TMO_RS03770	COG1393	Belongs to the ArsC family
TMO_RS03775	COG2866	Carboxypeptidase
TMO_RS03790	COG0513	Belongs to the DEAD box helicase family
TMO_RS03820	COG0534	Mate efflux family protein
TMO_RS03840	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TMO_RS03860	COG0768	penicillin binding
TMO_RS03865	COG0772	Belongs to the SEDS family
TMO_RS03885	COG0519	Catalyzes the synthesis of GMP from XMP
TMO_RS03890	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TMO_RS03895	COG1309	transcriptional regulator
TMO_RS03950	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TMO_RS03980	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TMO_RS03985	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
TMO_RS03995	COG0415	Belongs to the DNA photolyase family
TMO_RS04000	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TMO_RS04025	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_RS04065	COG0411	ABC transporter
TMO_RS04070	COG0410	ABC transporter
TMO_RS04090	COG0582	viral genome integration into host DNA
TMO_RS04100	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TMO_RS04115	COG2176	DNA-directed DNA polymerase activity
TMO_RS04115	COG5002	protein histidine kinase activity
TMO_RS04125	COG2267	carboxylic ester hydrolase activity
TMO_RS04145	COG0488	(ABC) transporter
TMO_RS04160	COG2853	Lipoprotein
TMO_RS04175	COG0646	methionine synthase
TMO_RS04175	COG1410	methionine synthase
TMO_RS04195	COG2161	toxin-antitoxin pair type II binding
TMO_RS04200	COG2175	clavaminate synthase activity
TMO_RS04215	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TMO_RS04230	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TMO_RS04235	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TMO_RS04270	COG0163	prenyltransferase activity
TMO_RS04275	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_RS04280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TMO_RS04285	COG2271	Major facilitator Superfamily
TMO_RS04305	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_RS04305	COG0604	alcohol dehydrogenase
TMO_RS04305	COG3321	synthase
TMO_RS04325	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_RS04340	COG1309	transcriptional regulator
TMO_RS04345	COG1079	Belongs to the binding-protein-dependent transport system permease family
TMO_RS04355	COG3845	ABC transporter
TMO_RS04360	COG1744	ABC transporter substrate-binding protein PnrA-like
TMO_RS04385	COG2113	Glycine betaine
TMO_RS04390	COG4176	ABC-type proline glycine betaine transport system permease component
TMO_RS04415	COG0254	rRNA binding
TMO_RS04435	COG0483	inositol monophosphate 1-phosphatase activity
TMO_RS04440	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TMO_RS04445	COG0352	thiamine-phosphate diphosphorylase activity
TMO_RS04450	COG1830	Aldolase
TMO_RS04460	COG0126	phosphoglycerate kinase activity
TMO_RS04475	COG1115	amino acid carrier protein
TMO_RS04480	COG1027	Aspartate ammonia-lyase
TMO_RS04485	COG0252	asparaginase activity
TMO_RS04510	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TMO_RS04520	COG0217	transcriptional regulatory protein
TMO_RS04525	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TMO_RS04530	COG0632	four-way junction helicase activity
TMO_RS04535	COG2255	four-way junction helicase activity
TMO_RS04540	COG0824	Thioesterase
TMO_RS04545	COG0154	amidase activity
TMO_RS04565	COG0823	Involved in the tonB-independent uptake of proteins
TMO_RS04570	COG2885	chlorophyll binding
TMO_RS04580	COG0037	tRNA processing
TMO_RS04585	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TMO_RS04595	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TMO_RS04605	COG0351	phosphomethylpyrimidine kinase
TMO_RS04625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TMO_RS04630	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TMO_RS04635	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TMO_RS04675	COG1396	sequence-specific DNA binding
TMO_RS04675	COG3800	Transcriptional regulator
TMO_RS04680	COG0745	RESPONSE REGULATOR receiver
TMO_RS04690	COG5002	protein histidine kinase activity
TMO_RS04705	COG0564	pseudouridine synthase activity
TMO_RS04735	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_RS04755	COG1396	sequence-specific DNA binding
TMO_RS04755	COG1917	Cupin 2, conserved barrel domain protein
TMO_RS04760	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TMO_RS04765	COG0686	Belongs to the AlaDH PNT family
TMO_RS04785	COG2363	Small membrane protein
TMO_RS04790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TMO_RS04805	COG0577	efflux transmembrane transporter activity
TMO_RS04805	COG1136	(ABC) transporter
TMO_RS04810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TMO_RS04815	COG2326	polyphosphate kinase activity
TMO_RS04840	COG0123	including yeast histone deacetylase and acetoin utilization protein
TMO_RS04845	COG1722	exodeoxyribonuclease VII activity
TMO_RS04850	COG0142	geranyltranstransferase activity
TMO_RS04855	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TMO_RS04860	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
TMO_RS04865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TMO_RS04880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TMO_RS04890	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_RS04900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TMO_RS04905	COG2030	dehydratase
TMO_RS04920	COG1960	acyl-CoA dehydrogenase activity
TMO_RS04935	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TMO_RS04940	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TMO_RS04945	COG1295	ribonuclease BN
TMO_RS04955	COG4520	surface antigen
TMO_RS04965	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TMO_RS04970	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TMO_RS04975	COG2818	Glycosylase
TMO_RS04980	COG0354	folic acid binding
TMO_RS04990	COG0438	transferase activity, transferring glycosyl groups
TMO_RS04995	COG0438	transferase activity, transferring glycosyl groups
TMO_RS05000	COG0367	asparagine synthase
TMO_RS05005	COG5342	invasion associated locus B
TMO_RS05030	COG0717	Belongs to the dCTP deaminase family
TMO_RS05045	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TMO_RS05050	COG5328	Belongs to the UPF0262 family
TMO_RS05055	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TMO_RS05070	COG1530	ribonuclease E activity
TMO_RS05075	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
TMO_RS05125	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TMO_RS05130	COG0583	DNA-binding transcription factor activity
TMO_RS05145	COG3383	formate dehydrogenase (NAD+) activity
TMO_RS05150	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TMO_RS05170	COG1012	belongs to the aldehyde dehydrogenase family
TMO_RS05175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TMO_RS05195	COG0601	transmembrane transport
TMO_RS05200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TMO_RS05255	COG0667	Aldo Keto reductase
TMO_RS05265	COG4774	siderophore transport
TMO_RS05275	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TMO_RS05350	COG0737	Belongs to the 5'-nucleotidase family
TMO_RS05370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TMO_RS05385	COG1012	belongs to the aldehyde dehydrogenase family
TMO_RS05450	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
TMO_RS05455	COG1215	transferase activity, transferring glycosyl groups
TMO_RS05460	COG1215	transferase activity, transferring glycosyl groups
TMO_RS05470	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
TMO_RS05515	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TMO_RS05525	COG4786	Flagellar basal body rod
TMO_RS05530	COG4786	Flagellar basal body rod
TMO_RS05555	COG0745	RESPONSE REGULATOR receiver
TMO_RS05580	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TMO_RS05610	COG0583	DNA-binding transcription factor activity
TMO_RS05620	COG1338	Plays a role in the flagellum-specific transport system
TMO_RS05650	COG1558	bacterial-type flagellum-dependent cell motility
TMO_RS05655	COG1677	Flagellar hook-basal body complex protein FliE
TMO_RS05660	COG1987	bacterial-type flagellum assembly
TMO_RS05665	COG1684	flagellar biosynthetic protein fliR
TMO_RS05670	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TMO_RS05690	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TMO_RS05705	COG0456	acetyltransferase
TMO_RS05710	COG0523	cobalamin synthesis protein
TMO_RS05715	COG1250	3-hydroxyacyl-CoA dehydrogenase
TMO_RS05720	COG0538	isocitrate dehydrogenase activity
TMO_RS05735	COG2814	Major facilitator Superfamily
TMO_RS05755	COG1309	transcriptional regulator
TMO_RS05765	COG0625	glutathione transferase activity
TMO_RS05770	COG0625	glutathione transferase activity
TMO_RS05775	COG1172	Belongs to the binding-protein-dependent transport system permease family
TMO_RS05780	COG1129	ABC transporter
TMO_RS05785	COG1879	ABC-type sugar transport system periplasmic component
TMO_RS05790	COG1984	allophanate hydrolase subunit 2
TMO_RS05805	COG0511	ligase activity, forming carbon-carbon bonds
TMO_RS05810	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TMO_RS05815	COG0583	DNA-binding transcription factor activity
TMO_RS05825	COG0693	protein deglycase activity
TMO_RS05835	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TMO_RS05845	COG1349	DNA-binding transcription factor activity
TMO_RS05855	COG1733	regulation of RNA biosynthetic process
TMO_RS05885	COG2226	methyltransferase
TMO_RS05890	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TMO_RS05895	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
TMO_RS05930	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TMO_RS05950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TMO_RS05960	COG4608	Belongs to the ABC transporter superfamily
TMO_RS05965	COG0444	Belongs to the ABC transporter superfamily
TMO_RS05970	COG0747	negative chemotaxis
TMO_RS06000	COG3845	ABC transporter
TMO_RS06005	COG1335	isochorismatase
TMO_RS06010	COG1079	Belongs to the binding-protein-dependent transport system permease family
TMO_RS06040	COG0746	molybdenum cofactor guanylyltransferase activity
TMO_RS06045	COG2076	Multidrug Resistance protein
TMO_RS06075	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_RS06085	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
TMO_RS06095	COG0308	aminopeptidase N
TMO_RS06115	COG1434	Gram-negative-bacterium-type cell wall biogenesis
TMO_RS06155	COG2198	Histidine kinase
TMO_RS06155	COG0784	Response regulator, receiver
TMO_RS06155	COG0643	Histidine kinase
TMO_RS06165	COG2201	protein-glutamate methylesterase activity
TMO_RS06170	COG2201	protein-glutamate methylesterase activity
TMO_RS06175	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TMO_RS06180	COG0745	RESPONSE REGULATOR receiver
TMO_RS06210	COG2271	Major facilitator Superfamily
TMO_RS06250	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TMO_RS06255	COG2204	response regulator
TMO_RS06260	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TMO_RS06265	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TMO_RS06275	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TMO_RS06280	COG1766	The M ring may be actively involved in energy transduction
TMO_RS06290	COG1749	Flagellar hook protein flgE
TMO_RS06295	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TMO_RS06305	COG2205	protein histidine kinase activity
TMO_RS06305	COG2202	Pas domain
TMO_RS06315	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TMO_RS06320	COG2203	Gaf domain
TMO_RS06320	COG3706	GGDEF domain
TMO_RS06320	COG5001	Diguanylate cyclase
TMO_RS06320	COG4251	negative regulation of phosphorylation
TMO_RS06325	COG0583	DNA-binding transcription factor activity
TMO_RS06390	COG0641	radical SAM
TMO_RS06405	COG4336	lyase activity
TMO_RS06410	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TMO_RS06420	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TMO_RS06440	COG1902	pentaerythritol trinitrate reductase activity
TMO_RS06455	COG0803	Belongs to the bacterial solute-binding protein 9 family
TMO_RS06470	COG1024	Enoyl-CoA hydratase
TMO_RS06475	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_RS06480	COG4221	oxidoreductase activity
TMO_RS06500	COG1172	Belongs to the binding-protein-dependent transport system permease family
TMO_RS06510	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TMO_RS06520	COG1070	Carbohydrate kinase
TMO_RS06525	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_RS06555	COG4771	TonB-dependent receptor
TMO_RS06575	COG0697	spore germination
TMO_RS06630	COG0395	ABC-type sugar transport system, permease component
TMO_RS06635	COG1175	transmembrane transport
TMO_RS06640	COG1653	transport
TMO_RS06645	COG3842	ATPase activity
TMO_RS06670	COG0523	cobalamin synthesis protein
TMO_RS06685	COG1522	sequence-specific DNA binding
TMO_RS06690	COG4771	TonB-dependent receptor
TMO_RS06705	COG4558	Periplasmic binding protein
TMO_RS06710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TMO_RS06715	COG1120	ATPase activity
TMO_RS06725	COG1970	mechanosensitive ion channel activity
TMO_RS06745	COG0811	peptide transport
TMO_RS06780	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
TMO_RS06795	COG1741	Belongs to the pirin family
TMO_RS06800	COG0006	proline dipeptidase activity
TMO_RS06830	COG1492	cobalamin metabolic process
TMO_RS06850	COG1643	Atp-dependent helicase
TMO_RS06855	COG1054	Belongs to the UPF0176 family
TMO_RS06860	COG0583	DNA-binding transcription factor activity
TMO_RS06865	COG0154	amidase activity
TMO_RS06895	COG0546	phosphoglycolate phosphatase activity
TMO_RS06905	COG1960	acyl-CoA dehydrogenase activity
TMO_RS06935	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_RS06945	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_RS06970	COG0735	belongs to the Fur family
TMO_RS06975	COG1121	(ABC) transporter
TMO_RS06980	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TMO_RS06995	COG1176	ABC-type spermidine putrescine transport system, permease component I
TMO_RS07000	COG3842	ATPase activity
TMO_RS07045	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TMO_RS07050	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_RS07055	COG1250	3-hydroxyacyl-CoA dehydrogenase
TMO_RS07055	COG1024	Enoyl-CoA hydratase
TMO_RS07060	COG1802	Transcriptional regulator
TMO_RS07075	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TMO_RS07085	COG1024	Enoyl-CoA hydratase
TMO_RS07090	COG0657	acetylesterase activity
TMO_RS07100	COG0154	amidase activity
TMO_RS07115	COG0656	L-ascorbic acid biosynthetic process
TMO_RS07130	COG0747	negative chemotaxis
TMO_RS07135	COG0601	transmembrane transport
TMO_RS07165	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TMO_RS07165	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TMO_RS07185	COG4647	ligase activity
TMO_RS07190	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
TMO_RS07195	COG0145	ligase activity
TMO_RS07200	COG3284	Transcriptional regulator
TMO_RS07215	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_RS07230	COG0248	Ppx GppA phosphatase
TMO_RS07235	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TMO_RS07245	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TMO_RS07245	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TMO_RS07255	COG1285	pathogenesis
TMO_RS07265	COG2267	carboxylic ester hydrolase activity
TMO_RS07270	COG0697	spore germination
TMO_RS07275	COG0519	Catalyzes the synthesis of GMP from XMP
TMO_RS07285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TMO_RS07285	COG3320	Male sterility
TMO_RS07290	COG0667	Aldo Keto reductase
TMO_RS07295	COG0583	DNA-binding transcription factor activity
TMO_RS07305	COG2274	protein secretion by the type I secretion system
TMO_RS07330	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
TMO_RS07335	COG1881	PFAM PEBP family protein
TMO_RS07350	COG5441	Belongs to the UPF0261 family
TMO_RS07355	COG5564	TIM-barrel signal transduction protein
TMO_RS07435	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TMO_RS07460	COG0730	response to heat
TMO_RS07465	COG0640	Transcriptional regulator
TMO_RS07470	COG0450	alkyl hydroperoxide reductase
TMO_RS07475	COG1522	sequence-specific DNA binding
TMO_RS07505	COG0604	alcohol dehydrogenase
TMO_RS07510	COG1309	transcriptional regulator
TMO_RS07535	COG3655	Transcriptional regulator
TMO_RS07540	COG0625	glutathione transferase activity
TMO_RS07575	COG0316	Belongs to the HesB IscA family
TMO_RS07580	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TMO_RS07600	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TMO_RS07605	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TMO_RS07620	COG2274	protein secretion by the type I secretion system
TMO_RS07665	COG1305	Transglutaminase-like
TMO_RS07675	COG2308	Evidence 4 Homologs of previously reported genes of
TMO_RS07680	COG2172	sigma factor antagonist activity
TMO_RS07685	COG1366	Belongs to the anti-sigma-factor antagonist family
TMO_RS07695	COG1253	flavin adenine dinucleotide binding
TMO_RS07700	COG1253	flavin adenine dinucleotide binding
TMO_RS07710	COG1840	ABC-type Fe3 transport system, periplasmic component
TMO_RS07715	COG1178	ABC-type Fe3 transport system permease component
TMO_RS07720	COG3842	ATPase activity
TMO_RS07725	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TMO_RS07730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TMO_RS07735	COG0805	protein transport
TMO_RS07750	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TMO_RS07755	COG4942	peptidase
TMO_RS07760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TMO_RS07775	COG1862	Preprotein translocase
TMO_RS07780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TMO_RS07795	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TMO_RS07800	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TMO_RS07815	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TMO_RS07825	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TMO_RS07830	COG0840	transmembrane signaling receptor activity
TMO_RS07840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TMO_RS07850	COG4208	sulfate ABC transporter
TMO_RS07870	COG0629	single-stranded DNA binding
TMO_RS07880	COG1846	Transcriptional regulator
TMO_RS07885	COG1764	response to oxidative stress
TMO_RS07895	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TMO_RS07900	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TMO_RS07905	COG0343	queuine tRNA-ribosyltransferase activity
TMO_RS07910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TMO_RS07935	COG1012	belongs to the aldehyde dehydrogenase family
TMO_RS07940	COG3622	Belongs to the hyi family
TMO_RS07960	COG0741	lytic transglycosylase activity
TMO_RS07965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TMO_RS07975	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TMO_RS07980	COG1573	uracil-dna glycosylase
TMO_RS07995	COG1758	RNA polymerase activity
TMO_RS08005	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TMO_RS08010	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TMO_RS08015	COG0736	holo-[acyl-carrier-protein] synthase activity
TMO_RS08020	COG0681	Belongs to the peptidase S26 family
TMO_RS08030	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TMO_RS08055	COG0583	DNA-binding transcription factor activity
TMO_RS08060	COG1381	Involved in DNA repair and RecF pathway recombination
TMO_RS08065	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TMO_RS08070	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TMO_RS08080	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TMO_RS08085	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TMO_RS08090	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TMO_RS08100	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TMO_RS08120	COG0113	porphobilinogen synthase activity
TMO_RS08125	COG1024	Enoyl-CoA hydratase
TMO_RS08130	COG1846	Transcriptional regulator
TMO_RS08135	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TMO_RS08140	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TMO_RS08145	COG0596	Alpha beta hydrolase
TMO_RS08160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TMO_RS08165	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TMO_RS08175	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TMO_RS08190	COG0745	RESPONSE REGULATOR receiver
TMO_RS08205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TMO_RS08220	COG0438	transferase activity, transferring glycosyl groups
TMO_RS08230	COG1278	Cold shock
TMO_RS08235	COG1278	Cold shock
TMO_RS08275	COG0066	3-isopropylmalate dehydratase activity
TMO_RS08280	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TMO_RS08305	COG0356	it plays a direct role in the translocation of protons across the membrane
TMO_RS08315	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TMO_RS08315	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TMO_RS08320	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TMO_RS08350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TMO_RS08350	COG0574	Belongs to the PEP-utilizing enzyme family
TMO_RS08355	COG1174	glycine betaine transport
TMO_RS08360	COG1125	glycine betaine transport
TMO_RS08365	COG1174	glycine betaine transport
TMO_RS08370	COG1732	Glycine betaine
TMO_RS08385	COG0657	acetylesterase activity
TMO_RS08405	COG3328	transposase activity
TMO_RS08410	COG3328	transposase activity
TMO_RS08420	COG2951	lytic endotransglycosylase activity
TMO_RS08430	COG1686	Belongs to the peptidase S11 family
TMO_RS08435	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TMO_RS08445	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TMO_RS08450	COG0084	hydrolase, TatD family'
TMO_RS08455	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TMO_RS08455	COG0321	lipoyl(octanoyl) transferase activity
TMO_RS08470	COG2814	Major facilitator Superfamily
TMO_RS08490	COG0670	Belongs to the BI1 family
TMO_RS08510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TMO_RS08515	COG3956	TIGRFAM MazG family protein
TMO_RS08525	COG0459	protein refolding
TMO_RS08530	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TMO_RS08535	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TMO_RS08540	COG1923	regulation of RNA biosynthetic process
TMO_RS08550	COG0569	domain protein
TMO_RS08555	COG2204	response regulator
TMO_RS08580	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TMO_RS08580	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TMO_RS08585	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TMO_RS08590	COG1058	Belongs to the CinA family
TMO_RS08590	COG1546	Belongs to the CinA family
TMO_RS08595	COG1595	DNA-templated transcription, initiation
TMO_RS08610	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TMO_RS08615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TMO_RS08620	COG0508	dehydrogenase complex catalyzes the overall conversion of
TMO_RS08625	COG0508	dehydrogenase complex catalyzes the overall conversion of
TMO_RS08625	COG0022	dehydrogenase e1 component
TMO_RS08630	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TMO_RS08635	COG0583	DNA-binding transcription factor activity
TMO_RS08640	COG1024	Enoyl-CoA hydratase
TMO_RS08685	COG0831	urea catabolic process
TMO_RS08690	COG0832	Belongs to the urease beta subunit family
TMO_RS08695	COG0804	urea catabolic process
TMO_RS08705	COG0830	nickel cation binding
TMO_RS08710	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TMO_RS08765	COG0583	DNA-binding transcription factor activity
TMO_RS08775	COG0148	phosphopyruvate hydratase activity
TMO_RS08780	COG2877	3-deoxy-8-phosphooctulonate synthase activity
TMO_RS08785	COG0504	CTP synthase activity
TMO_RS08795	COG0149	triose-phosphate isomerase activity
TMO_RS08805	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TMO_RS08830	COG2217	Heavy metal translocating P-type atpase
TMO_RS08855	COG0303	'Molybdopterin
TMO_RS08885	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TMO_RS08890	COG3494	Protein of unknown function (DUF1009)
TMO_RS08895	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TMO_RS08900	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TMO_RS08905	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TMO_RS08915	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TMO_RS08920	COG0750	zinc metalloprotease
TMO_RS08925	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TMO_RS08945	COG0528	UMP kinase activity
TMO_RS08950	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TMO_RS08955	COG0052	Belongs to the universal ribosomal protein uS2 family
TMO_RS08990	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TMO_RS09000	COG1024	Enoyl-CoA hydratase
TMO_RS09005	COG1832	CoA-binding protein
TMO_RS09010	COG2873	o-acetylhomoserine
TMO_RS09035	COG0583	DNA-binding transcription factor activity
TMO_RS09040	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TMO_RS09065	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TMO_RS09080	COG1324	tolerance protein
TMO_RS09085	COG0745	RESPONSE REGULATOR receiver
TMO_RS09100	COG0776	regulation of translation
TMO_RS09105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TMO_RS09110	COG0416	fatty acid biosynthetic process
TMO_RS09145	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TMO_RS09155	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TMO_RS09170	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TMO_RS09170	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TMO_RS09180	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TMO_RS09185	COG0698	ribose 5-phosphate isomerase
TMO_RS09190	COG4957	zinc ion binding
TMO_RS09225	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
TMO_RS09240	COG0628	permease
TMO_RS09255	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TMO_RS09260	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TMO_RS09265	COG0105	UTP biosynthetic process
TMO_RS09270	COG0488	(ABC) transporter
TMO_RS09285	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TMO_RS09300	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
TMO_RS09305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TMO_RS09310	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TMO_RS09315	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TMO_RS09325	COG0194	GDP metabolic process
TMO_RS09330	COG1561	YicC-like family, N-terminal region
TMO_RS09340	COG4206	TonB-dependent receptor
TMO_RS09350	COG4139	cobalamin transport
TMO_RS09355	COG1120	ATPase activity
TMO_RS09365	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TMO_RS09370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TMO_RS09375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TMO_RS09385	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TMO_RS09390	COG0360	Binds together with S18 to 16S ribosomal RNA
TMO_RS09395	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TMO_RS09410	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TMO_RS09415	COG0305	Participates in initiation and elongation during chromosome replication
TMO_RS09420	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TMO_RS09425	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TMO_RS09430	COG1127	ABC transporter
TMO_RS09440	COG1286	toxin biosynthetic process
TMO_RS09445	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TMO_RS09450	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_RS09470	COG1160	GTP binding
TMO_RS09485	COG1752	Esterase of the alpha-beta hydrolase superfamily
TMO_RS09520	COG3145	DNA-N1-methyladenine dioxygenase activity
TMO_RS09550	COG4993	Dehydrogenase
TMO_RS09560	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TMO_RS09585	COG0525	valine-tRNA ligase activity
TMO_RS09600	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TMO_RS09635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TMO_RS09675	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TMO_RS09695	COG0587	DNA-directed DNA polymerase activity
TMO_RS09700	COG3963	phosphatidate phosphatase activity
TMO_RS09710	COG2719	SpoVR family
TMO_RS09715	COG2718	Belongs to the UPF0229 family
TMO_RS09720	COG2766	serine protein kinase
TMO_RS09750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TMO_RS09755	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TMO_RS09760	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TMO_RS09765	COG1494	fructose-1,6-bisphosphatase
TMO_RS09775	COG0436	Aminotransferase
TMO_RS09780	COG3243	poly(R)-hydroxyalkanoic acid synthase
TMO_RS09790	COG2814	Major facilitator Superfamily
TMO_RS09795	COG2855	membrane
TMO_RS09800	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TMO_RS09805	COG1136	(ABC) transporter
TMO_RS09810	COG4591	ABC-type transport system involved in lipoprotein release permease component
TMO_RS09825	COG2252	PERMEase
TMO_RS09845	COG0583	DNA-binding transcription factor activity
TMO_RS09850	COG1280	lysine exporter protein (LysE YggA)
TMO_RS09860	COG0346	lactoylglutathione lyase activity
TMO_RS09875	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TMO_RS09875	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TMO_RS09880	COG1007	ATP synthesis coupled electron transport
TMO_RS09895	COG0713	ATP synthesis coupled electron transport
TMO_RS09905	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TMO_RS09910	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TMO_RS09915	COG1034	ATP synthesis coupled electron transport
TMO_RS09930	COG0649	NAD binding
TMO_RS09935	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TMO_RS09940	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TMO_RS09945	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TMO_RS09955	COG2072	flavoprotein involved in K transport
TMO_RS09965	COG0776	regulation of translation
TMO_RS09980	COG0740	serine-type endopeptidase activity
TMO_RS10010	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TMO_RS10010	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TMO_RS10030	COG0436	Aminotransferase
TMO_RS10040	COG0174	glutamine synthetase
TMO_RS10050	COG0583	DNA-binding transcription factor activity
TMO_RS10060	COG0187	DNA topoisomerase II activity
TMO_RS10080	COG0840	transmembrane signaling receptor activity
TMO_RS10100	COG0513	Belongs to the DEAD box helicase family
TMO_RS10105	COG0596	Alpha beta hydrolase
TMO_RS10105	COG2945	thiolester hydrolase activity
TMO_RS10140	COG2819	hydrolase of the alpha beta superfamily
TMO_RS10150	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TMO_RS10150	COG1017	nitric oxide dioxygenase activity
TMO_RS10175	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TMO_RS10195	COG0747	negative chemotaxis
TMO_RS10200	COG0601	transmembrane transport
TMO_RS10205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TMO_RS10210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TMO_RS10215	COG1968	undecaprenyl-diphosphatase activity
TMO_RS10220	COG1024	Enoyl-CoA hydratase
TMO_RS10230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TMO_RS10235	COG1024	Enoyl-CoA hydratase
TMO_RS10255	COG2814	Major facilitator Superfamily
TMO_RS10260	COG2207	Transcriptional regulator
TMO_RS10265	COG1522	sequence-specific DNA binding
TMO_RS10270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TMO_RS10325	COG0156	8-amino-7-oxononanoate synthase activity
TMO_RS10335	COG1132	(ABC) transporter
TMO_RS10335	COG1132	(ABC) transporter
TMO_RS10350	COG2992	FlgJ-related protein
TMO_RS10360	COG2205	protein histidine kinase activity
TMO_RS10365	COG0745	RESPONSE REGULATOR receiver
TMO_RS10385	COG1201	RNA secondary structure unwinding
TMO_RS10395	COG1793	dna ligase
TMO_RS10395	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TMO_RS10400	COG1752	Esterase of the alpha-beta hydrolase superfamily
TMO_RS10410	COG2211	Major facilitator Superfamily
TMO_RS10430	COG4771	TonB-dependent receptor
TMO_RS10445	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
TMO_RS10460	COG0729	surface antigen
TMO_RS10490	COG0183	Belongs to the thiolase family
TMO_RS10495	COG1250	3-hydroxyacyl-CoA dehydrogenase
TMO_RS10510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TMO_RS10515	COG3639	organic phosphonate transmembrane transporter activity
TMO_RS10520	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
TMO_RS10530	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
TMO_RS10540	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
TMO_RS10540	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
TMO_RS10545	COG3454	Phosphonate metabolism
TMO_RS10550	COG4778	phosphonate C-P lyase system protein PhnL
TMO_RS10555	COG4107	phosphonate C-P lyase system protein PhnK
TMO_RS10560	COG3627	carbon phosphorus lyase activity
TMO_RS10565	COG3626	phosphonate metabolism
TMO_RS10570	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
TMO_RS10575	COG3624	Phosphonate C-P lyase system protein PhnG
TMO_RS10580	COG1609	Transcriptional regulator
TMO_RS10625	COG0697	spore germination
TMO_RS10635	COG1376	ErfK ybiS ycfS ynhG family protein
TMO_RS10645	COG0384	phenazine biosynthesis protein PhzF
TMO_RS10655	COG1765	OsmC-like protein
TMO_RS10660	COG2814	Major facilitator Superfamily
TMO_RS10665	COG1752	Esterase of the alpha-beta hydrolase superfamily
TMO_RS10670	COG2264	protein methyltransferase activity
TMO_RS10675	COG0484	heat shock protein binding
TMO_RS10685	COG0471	metal ion transport
TMO_RS10685	COG0490	domain, Protein
TMO_RS10690	COG0625	glutathione transferase activity
TMO_RS10695	COG2366	antibiotic biosynthetic process
TMO_RS10715	COG1802	Transcriptional regulator
TMO_RS10725	COG0179	Fumarylacetoacetate (FAA) hydrolase
TMO_RS10750	COG4214	carbohydrate transport
TMO_RS10765	COG1659	Linocin_M18 bacteriocin protein
TMO_RS10785	COG3135	benzoate transporter
TMO_RS10790	COG1763	Mo-molybdopterin cofactor biosynthetic process
TMO_RS10795	COG1116	anion transmembrane transporter activity
TMO_RS10795	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TMO_RS10805	COG1116	anion transmembrane transporter activity
TMO_RS10810	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TMO_RS10815	COG2146	nitrite reductase [NAD(P)H] activity
TMO_RS10820	COG0243	molybdopterin cofactor binding
TMO_RS10825	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TMO_RS10825	COG1648	precorrin-2 dehydrogenase activity
TMO_RS10830	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TMO_RS10835	COG2198	Histidine kinase
TMO_RS10835	COG2205	protein histidine kinase activity
TMO_RS10835	COG0784	Response regulator, receiver
TMO_RS10835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TMO_RS10845	COG0786	glutamate:sodium symporter activity
TMO_RS10850	COG0842	Transport permease protein
TMO_RS10855	COG1129	ABC transporter
TMO_RS10855	COG0842	Transport permease protein
TMO_RS10860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TMO_RS10900	COG1546	Belongs to the CinA family
TMO_RS10900	COG1058	Belongs to the CinA family
TMO_RS10910	COG1489	DNA binding
TMO_RS10915	COG0024	Methionine aminopeptidase
TMO_RS10920	COG2003	Belongs to the UPF0758 family
TMO_RS10965	COG0678	peroxiredoxin activity
TMO_RS10965	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
TMO_RS10970	COG0789	Transcriptional regulator
TMO_RS10980	COG2207	Transcriptional regulator
TMO_RS10980	COG1917	Cupin 2, conserved barrel domain protein
TMO_RS10985	COG1309	transcriptional regulator
TMO_RS10990	COG1733	regulation of RNA biosynthetic process
TMO_RS11010	COG0583	DNA-binding transcription factor activity
TMO_RS11030	COG3846	protein secretion by the type IV secretion system
TMO_RS11045	COG3451	type IV secretory pathway VirB4
TMO_RS11060	COG4962	Type ii secretion system protein e
TMO_RS11090	COG0681	Belongs to the peptidase S26 family
TMO_RS11105	COG1192	Involved in chromosome partitioning
TMO_RS11130	COG1476	TRANSCRIPTIONal
TMO_RS11140	COG5489	Protein of unknown function (DUF736)
TMO_RS11145	COG0587	DNA-directed DNA polymerase activity
TMO_RS11265	COG2132	Multicopper oxidase
TMO_RS11295	COG0789	Transcriptional regulator
TMO_RS11300	COG2814	Major facilitator Superfamily
TMO_RS11325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TMO_RS11330	COG0583	DNA-binding transcription factor activity
TMO_RS11340	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TMO_RS11345	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TMO_RS11365	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TMO_RS11370	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TMO_RS11375	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TMO_RS11380	COG0047	phosphoribosylformylglycinamidine synthase activity
TMO_RS11390	COG0271	Belongs to the BolA IbaG family
TMO_RS11395	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TMO_RS11415	COG4774	siderophore transport
TMO_RS11435	COG0402	S-adenosylhomocysteine deaminase activity
TMO_RS11450	COG0583	DNA-binding transcription factor activity
TMO_RS11485	COG2010	Cytochrome c
TMO_RS11510	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TMO_RS11515	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TMO_RS11520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TMO_RS11530	COG4771	TonB-dependent receptor
TMO_RS11540	COG1335	isochorismatase
TMO_RS11545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TMO_RS11560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TMO_RS11575	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
TMO_RS11600	COG0179	Fumarylacetoacetate (FAA) hydrolase
TMO_RS11610	COG1228	amidohydrolase
TMO_RS11615	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TMO_RS11720	COG3263	regulation of cellular component size
TMO_RS11750	COG0175	sulfate reduction
TMO_RS11755	COG1218	3'(2'),5'-bisphosphate nucleotidase
TMO_RS11760	COG2137	regulation of response to DNA damage stimulus
TMO_RS11765	COG1192	Involved in chromosome partitioning
TMO_RS11775	COG0009	L-threonylcarbamoyladenylate synthase
TMO_RS11790	COG0277	FAD linked oxidase domain protein
TMO_RS11800	COG2986	histidine ammonia-lyase
TMO_RS11805	COG0402	S-adenosylhomocysteine deaminase activity
TMO_RS11810	COG1228	amidohydrolase
TMO_RS11825	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TMO_RS11840	COG1280	lysine exporter protein (LysE YggA)
TMO_RS11850	COG0840	transmembrane signaling receptor activity
TMO_RS11855	COG2205	protein histidine kinase activity
TMO_RS11865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TMO_RS11890	COG1309	transcriptional regulator
TMO_RS11995	COG4373	Mu-like prophage FluMu protein gp28
TMO_RS12115	COG0183	Belongs to the thiolase family
TMO_RS12120	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TMO_RS12130	COG3800	Transcriptional regulator
TMO_RS12130	COG1396	sequence-specific DNA binding
TMO_RS12145	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
TMO_RS12150	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TMO_RS12155	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TMO_RS12155	COG2755	lipolytic protein G-D-S-L family
TMO_RS12175	COG1024	Enoyl-CoA hydratase
TMO_RS12185	COG1764	response to oxidative stress
TMO_RS12200	COG0640	Transcriptional regulator
TMO_RS12215	COG0025	NhaP-type Na H and K H
TMO_RS12230	COG3485	protocatechuate 3,4-dioxygenase
TMO_RS12235	COG3485	protocatechuate 3,4-dioxygenase
TMO_RS12240	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TMO_RS12245	COG0583	DNA-binding transcription factor activity
TMO_RS12260	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TMO_RS12300	COG0517	IMP dehydrogenase activity
TMO_RS12315	COG1522	sequence-specific DNA binding
TMO_RS12330	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TMO_RS12380	COG0583	DNA-binding transcription factor activity
TMO_RS12415	COG0667	Aldo Keto reductase
TMO_RS12455	COG1116	anion transmembrane transporter activity
TMO_RS12460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TMO_RS12465	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TMO_RS12470	COG1863	multisubunit Na H antiporter MnhE subunit
TMO_RS12495	COG1006	Multisubunit Na H antiporter MnhC subunit
TMO_RS12500	COG0651	ATP synthesis coupled electron transport
TMO_RS12505	COG0651	ATP synthesis coupled electron transport
TMO_RS12515	COG0651	ATP synthesis coupled electron transport
TMO_RS12540	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_RS12550	COG2207	Transcriptional regulator
TMO_RS12575	COG0501	Belongs to the peptidase M48B family
TMO_RS12585	COG0450	alkyl hydroperoxide reductase
TMO_RS12590	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TMO_RS12595	COG0367	asparagine synthase
TMO_RS12600	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TMO_RS12600	COG0189	ligase activity
TMO_RS12605	COG1363	Peptidase, m42
TMO_RS12615	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TMO_RS12625	COG2897	thiosulfate sulfurtransferase activity
TMO_RS12650	COG1126	abc transporter atp-binding protein
TMO_RS12655	COG0765	amino acid transport
TMO_RS12660	COG4597	amino acid ABC transporter
TMO_RS12665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TMO_RS12670	COG0626	cystathionine gamma-synthase activity
TMO_RS12685	COG2204	response regulator
TMO_RS12710	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
TMO_RS12740	COG1024	Enoyl-CoA hydratase
TMO_RS12745	COG1024	Enoyl-CoA hydratase
TMO_RS12750	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TMO_RS12755	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TMO_RS12760	COG3842	ATPase activity
TMO_RS12765	COG1176	ABC-type spermidine putrescine transport system, permease component I
TMO_RS12770	COG1177	transmembrane transport
TMO_RS12775	COG1012	belongs to the aldehyde dehydrogenase family
TMO_RS12785	COG0300	oxidoreductase activity
TMO_RS12790	COG0438	transferase activity, transferring glycosyl groups
TMO_RS12795	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TMO_RS12800	COG1115	amino acid carrier protein
TMO_RS12810	COG1131	(ABC) transporter
TMO_RS12815	COG0842	Transport permease protein
TMO_RS12820	COG0540	Belongs to the ATCase OTCase family
TMO_RS12825	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TMO_RS12830	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TMO_RS12845	COG0758	DNA mediated transformation
TMO_RS12850	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TMO_RS12855	COG0557	exoribonuclease II activity
TMO_RS12865	COG2814	Major facilitator Superfamily
TMO_RS12880	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TMO_RS12890	COG0784	Response regulator, receiver
TMO_RS12895	COG1940	carbohydrate kinase activity
TMO_RS12900	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TMO_RS12920	COG2067	long-chain fatty acid transport protein
TMO_RS12930	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TMO_RS12965	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
TMO_RS12970	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TMO_RS12980	COG1960	acyl-CoA dehydrogenase activity
TMO_RS12985	COG0183	Belongs to the thiolase family
TMO_RS12990	COG1960	acyl-CoA dehydrogenase activity
TMO_RS13000	COG0583	DNA-binding transcription factor activity
TMO_RS13020	COG2814	Major facilitator Superfamily
TMO_RS13025	COG1595	DNA-templated transcription, initiation
TMO_RS13045	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TMO_RS13050	COG2239	Acts as a magnesium transporter
TMO_RS13055	COG0281	malic enzyme
TMO_RS13055	COG0280	phosphate acetyltransferase
TMO_RS13060	COG0321	lipoyl(octanoyl) transferase activity
TMO_RS13065	COG1268	BioY protein
TMO_RS13075	COG1254	Belongs to the acylphosphatase family
TMO_RS13080	COG0277	FAD linked oxidase domain protein
TMO_RS13085	COG4770	biotin carboxylase activity
TMO_RS13095	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TMO_RS13105	COG0546	phosphoglycolate phosphatase activity
TMO_RS13110	COG0564	pseudouridine synthase activity
TMO_RS13115	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TMO_RS13120	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TMO_RS13125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TMO_RS13130	COG0203	ribosomal protein L17
TMO_RS13140	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TMO_RS13145	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TMO_RS13150	COG0563	adenylate kinase activity
TMO_RS13155	COG0201	protein transport
TMO_RS13160	COG0200	Binds to the 23S rRNA
TMO_RS13165	COG1841	ribosomal large subunit assembly
TMO_RS13170	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TMO_RS13180	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TMO_RS13185	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TMO_RS13190	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TMO_RS13200	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TMO_RS13210	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TMO_RS13215	COG0255	Belongs to the universal ribosomal protein uL29 family
TMO_RS13220	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TMO_RS13225	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TMO_RS13230	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TMO_RS13235	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TMO_RS13250	COG0088	Forms part of the polypeptide exit tunnel
TMO_RS13265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TMO_RS13275	COG0049	tRNA binding
TMO_RS13280	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TMO_RS13285	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TMO_RS13290	COG0085	RNA polymerase activity
TMO_RS13300	COG0222	ribosome binding
TMO_RS13305	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TMO_RS13310	COG0081	regulation of translation
TMO_RS13315	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TMO_RS13325	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TMO_RS13335	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TMO_RS13350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TMO_RS13360	COG0745	RESPONSE REGULATOR receiver
TMO_RS13380	COG5265	(ABC) transporter
TMO_RS13395	COG0415	Belongs to the DNA photolyase family
TMO_RS13400	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TMO_RS13400	COG0493	'glutamate synthase
TMO_RS13410	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TMO_RS13415	COG4221	oxidoreductase activity
TMO_RS13425	COG3046	protein related to deoxyribodipyrimidine photolyase
TMO_RS13430	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_RS13460	COG1537	nuclear-transcribed mRNA catabolic process, no-go decay
TMO_RS13465	COG1431	PFAM Stem cell self-renewal protein Piwi
TMO_RS13490	COG0848	biopolymer transport protein
TMO_RS13500	COG0521	Mo-molybdopterin cofactor biosynthetic process
TMO_RS13510	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TMO_RS13520	COG0463	Glycosyl transferase, family 2
TMO_RS13525	COG0642	Histidine kinase
TMO_RS13530	COG0745	RESPONSE REGULATOR receiver
TMO_RS13535	COG2816	NAD+ diphosphatase activity
TMO_RS13545	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TMO_RS13565	COG0783	Belongs to the Dps family
TMO_RS13575	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TMO_RS13600	COG0242	peptide deformylase activity
TMO_RS13605	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TMO_RS13630	COG1595	DNA-templated transcription, initiation
TMO_RS13640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TMO_RS13645	COG2171	N-acyltransferase activity
TMO_RS13655	COG5001	Diguanylate cyclase
TMO_RS13655	COG5002	protein histidine kinase activity
TMO_RS13660	COG0840	transmembrane signaling receptor activity
TMO_RS13665	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TMO_RS13670	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TMO_RS13675	COG0706	membrane insertase activity
TMO_RS13680	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TMO_RS13690	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TMO_RS13705	COG0398	Pfam SNARE associated Golgi protein
TMO_RS13720	COG4122	O-methyltransferase activity
TMO_RS13730	COG4172	Belongs to the ABC transporter superfamily
TMO_RS13735	COG0747	negative chemotaxis
TMO_RS13740	COG0601	transmembrane transport
TMO_RS13745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TMO_RS13755	COG1116	anion transmembrane transporter activity
TMO_RS13760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TMO_RS13765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TMO_RS13780	COG0583	DNA-binding transcription factor activity
TMO_RS13785	COG0803	Belongs to the bacterial solute-binding protein 9 family
TMO_RS13790	COG1121	(ABC) transporter
TMO_RS13795	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TMO_RS13800	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TMO_RS13805	COG2197	response regulator
TMO_RS13810	COG2205	protein histidine kinase activity
TMO_RS13850	COG2189	Belongs to the N(4) N(6)-methyltransferase family
TMO_RS13865	COG0583	DNA-binding transcription factor activity
TMO_RS13880	COG3795	YCII-related domain
TMO_RS13885	COG4941	Belongs to the sigma-70 factor family
TMO_RS13895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TMO_RS13895	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TMO_RS13935	COG2346	COG2346, Truncated hemoglobins
TMO_RS13950	COG1797	cobyrinic acid a,c-diamide synthase activity
TMO_RS13960	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TMO_RS13965	COG2099	Precorrin-6x reductase
TMO_RS13975	COG2875	Belongs to the precorrin methyltransferase family
TMO_RS14015	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TMO_RS14020	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TMO_RS14050	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TMO_RS14055	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TMO_RS14060	COG0509	glycine decarboxylation via glycine cleavage system
TMO_RS14065	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TMO_RS14080	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TMO_RS14085	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
TMO_RS14090	COG0328	RNA-DNA hybrid ribonuclease activity
TMO_RS14095	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TMO_RS14100	COG0678	peroxiredoxin activity
TMO_RS14105	COG4232	protein-disulfide reductase activity
TMO_RS14110	COG1678	Uncharacterized ACR, COG1678
TMO_RS14120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TMO_RS14125	COG0425	Belongs to the sulfur carrier protein TusA family
TMO_RS14130	COG0612	Peptidase, M16
TMO_RS14140	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TMO_RS14145	COG1612	heme a metabolic process
TMO_RS14165	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
TMO_RS14175	COG0109	protoheme IX farnesyltransferase activity
TMO_RS14185	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TMO_RS14190	COG0312	modulator of DNA gyrase
TMO_RS14200	COG2358	TRAP transporter, solute receptor (TAXI family
TMO_RS14205	COG3246	L-lysine catabolic process to acetate
TMO_RS14215	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TMO_RS14225	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TMO_RS14230	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TMO_RS14240	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TMO_RS14260	COG0312	modulator of DNA gyrase
TMO_RS14265	COG0483	inositol monophosphate 1-phosphatase activity
TMO_RS14270	COG1132	(ABC) transporter
TMO_RS14280	COG1519	Transferase
TMO_RS14285	COG1663	tetraacyldisaccharide 4'-kinase activity
TMO_RS14305	COG0154	amidase activity
TMO_RS14315	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_RS14325	COG4149	molybdate abc transporter
TMO_RS14335	COG3842	ATPase activity
TMO_RS14345	COG1846	Transcriptional regulator
TMO_RS14350	COG0747	negative chemotaxis
TMO_RS14360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TMO_RS14365	COG4172	Belongs to the ABC transporter superfamily
TMO_RS14370	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TMO_RS14410	COG3246	L-lysine catabolic process to acetate
TMO_RS14415	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TMO_RS14430	COG0765	amino acid transport
TMO_RS14435	COG0765	amino acid transport
TMO_RS14445	COG0583	DNA-binding transcription factor activity
TMO_RS14460	COG2169	Transcriptional regulator
TMO_RS14460	COG1917	Cupin 2, conserved barrel domain protein
TMO_RS14480	COG1570	exodeoxyribonuclease VII activity
TMO_RS14485	COG0151	Belongs to the GarS family
TMO_RS14490	COG1360	Flagellar Motor Protein
TMO_RS14500	COG0590	tRNA wobble adenosine to inosine editing
TMO_RS14505	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TMO_RS14545	COG0166	Belongs to the GPI family
TMO_RS14550	COG0612	Peptidase, M16
TMO_RS14555	COG0612	Peptidase, M16
TMO_RS14570	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TMO_RS14575	COG0196	riboflavin kinase activity
TMO_RS14580	COG2030	dehydratase
TMO_RS14585	COG0596	Alpha beta hydrolase
TMO_RS14595	COG2431	L-lysine efflux transmembrane transporter activity
TMO_RS14645	COG3842	ATPase activity
TMO_RS14650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TMO_RS14660	COG0024	Methionine aminopeptidase
TMO_RS14670	COG0840	transmembrane signaling receptor activity
TMO_RS14690	COG4303	Ethanolamine ammonia lyase large subunit
TMO_RS14700	COG3214	Protein conserved in bacteria
TMO_RS14705	COG3386	PFAM SMP-30 Gluconolaconase
TMO_RS14715	COG1120	ATPase activity
TMO_RS14720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TMO_RS14735	COG4771	TonB-dependent receptor
TMO_RS14740	COG0583	DNA-binding transcription factor activity
TMO_RS14775	COG3284	Transcriptional regulator
TMO_RS14780	COG1122	ATPase activity
TMO_RS14785	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TMO_RS14795	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
TMO_RS14800	COG0310	cobalt ion transport
TMO_RS14805	COG3795	YCII-related domain
TMO_RS14825	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TMO_RS14850	COG4335	DNA alkylation repair
TMO_RS14860	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TMO_RS14865	COG2986	histidine ammonia-lyase
TMO_RS14870	COG4175	Glycine betaine
TMO_RS14870	COG0517	IMP dehydrogenase activity
TMO_RS14875	COG4176	ABC-type proline glycine betaine transport system permease component
TMO_RS14895	COG1522	sequence-specific DNA binding
TMO_RS14925	COG3609	addiction module antidote protein, CC2985 family
TMO_RS14930	COG1335	isochorismatase
TMO_RS14945	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TMO_RS14950	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TMO_RS14955	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TMO_RS14965	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TMO_RS14970	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TMO_RS14975	COG0799	negative regulation of ribosome biogenesis
TMO_RS14980	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TMO_RS14985	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TMO_RS14990	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TMO_RS15000	COG0793	Belongs to the peptidase S41A family
TMO_RS15010	COG0494	nUDIX hydrolase
TMO_RS15015	COG0725	ABC transporter, periplasmic molybdate-binding protein
TMO_RS15020	COG4149	molybdate abc transporter
TMO_RS15025	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TMO_RS15050	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TMO_RS15055	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TMO_RS15070	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TMO_RS15080	COG4974	Belongs to the 'phage' integrase family
TMO_RS15085	COG2132	Multicopper oxidase
TMO_RS15095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TMO_RS15105	COG1136	(ABC) transporter
TMO_RS15125	COG1595	DNA-templated transcription, initiation
TMO_RS15140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TMO_RS15145	COG0508	dehydrogenase complex catalyzes the overall conversion of
TMO_RS15160	COG0045	succinate-CoA ligase (ADP-forming) activity
TMO_RS15165	COG0039	L-malate dehydrogenase activity
TMO_RS15170	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
TMO_RS15175	COG0405	Gamma-glutamyltransferase
TMO_RS15180	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TMO_RS15195	COG4608	Belongs to the ABC transporter superfamily
TMO_RS15200	COG0444	Belongs to the ABC transporter superfamily
TMO_RS15205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TMO_RS15210	COG0601	transmembrane transport
TMO_RS15215	COG0747	negative chemotaxis
TMO_RS15220	COG0435	Glutathione S-transferase
TMO_RS15225	COG0655	NAD(P)H dehydrogenase (quinone) activity
TMO_RS15245	COG0069	glutamate synthase activity
TMO_RS15245	COG0070	glutamate synthase
TMO_RS15245	COG0067	glutamate synthase
TMO_RS15260	COG0372	Belongs to the citrate synthase family
TMO_RS15270	COG2010	Cytochrome c
TMO_RS15295	COG0564	pseudouridine synthase activity
TMO_RS15300	COG0251	oxidation-reduction process
TMO_RS15305	COG0494	nUDIX hydrolase
TMO_RS15325	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
TMO_RS15335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TMO_RS15380	COG0501	Belongs to the peptidase M48B family
TMO_RS15395	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TMO_RS15410	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TMO_RS15440	COG1022	Amp-dependent synthetase and ligase
TMO_RS15470	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TMO_RS15490	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TMO_RS15495	COG1802	Transcriptional regulator
TMO_RS15505	COG4133	protoheme IX ABC transporter activity
TMO_RS15525	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TMO_RS15530	COG1138	Cytochrome C-type biogenesis protein
TMO_RS15535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TMO_RS15540	COG3088	subunit of a heme lyase
TMO_RS15620	COG1872	DUF167
TMO_RS15625	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TMO_RS15665	COG0625	glutathione transferase activity
TMO_RS15670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TMO_RS15675	COG0535	radical SAM domain protein
TMO_RS15685	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
TMO_RS15690	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TMO_RS15695	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TMO_RS15705	COG0670	Belongs to the BI1 family
TMO_RS15715	COG0138	bifunctional purine biosynthesis protein purh
TMO_RS15755	COG1846	Transcriptional regulator
TMO_RS15775	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TMO_RS15795	COG2835	tetraacyldisaccharide 4'-kinase activity
TMO_RS15805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TMO_RS15810	COG0347	Belongs to the P(II) protein family
TMO_RS15815	COG0004	ammonium transporteR
TMO_RS15820	COG0436	Aminotransferase
TMO_RS15825	COG1674	ftsk spoiiie
TMO_RS15840	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TMO_RS15850	COG1115	amino acid carrier protein
TMO_RS15860	COG1999	signal sequence binding
TMO_RS15880	COG0406	alpha-ribazole phosphatase activity
TMO_RS15885	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TMO_RS15890	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TMO_RS15900	COG1595	DNA-templated transcription, initiation
TMO_RS15905	COG3806	Anti-sigma factor
TMO_RS15915	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
TMO_RS15940	COG2154	pterin-4-alpha-carbinolamine dehydratase
TMO_RS15960	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TMO_RS15975	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TMO_RS15990	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TMO_RS16005	COG0436	Aminotransferase
TMO_RS16010	COG0352	thiamine-phosphate diphosphorylase activity
TMO_RS16020	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
TMO_RS16025	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TMO_RS16030	COG2358	TRAP transporter, solute receptor (TAXI family
TMO_RS16035	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TMO_RS16050	COG4172	Belongs to the ABC transporter superfamily
TMO_RS16060	COG4174	ABC transporter (Permease)
TMO_RS16065	COG4166	transmembrane transport
TMO_RS16075	COG3474	cytochrome
TMO_RS16080	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TMO_RS16095	COG1396	sequence-specific DNA binding
TMO_RS16110	COG4181	ATPase activity
TMO_RS16130	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TMO_RS16135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TMO_RS16140	COG0583	DNA-binding transcription factor activity
TMO_RS16150	COG0596	Alpha beta hydrolase
TMO_RS16175	COG1131	(ABC) transporter
TMO_RS16185	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TMO_RS16185	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TMO_RS16215	COG0071	Belongs to the small heat shock protein (HSP20) family
TMO_RS16230	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TMO_RS16240	COG0539	negative regulation of cytoplasmic translation
TMO_RS16280	COG0395	ABC-type sugar transport system, permease component
TMO_RS16285	COG0616	signal peptide processing
TMO_RS16290	COG0776	regulation of translation
TMO_RS16305	COG0135	phosphoribosylanthranilate isomerase activity
TMO_RS16310	COG0133	tryptophan synthase activity
TMO_RS16320	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TMO_RS16325	COG0285	dihydrofolate synthase activity
TMO_RS16350	COG1074	ATP-dependent DNA helicase activity
TMO_RS16355	COG2887	Belongs to the helicase family. UvrD subfamily
TMO_RS16360	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TMO_RS16365	COG3178	'Phosphotransferase
TMO_RS16370	COG0802	atpase or kinase
TMO_RS16380	COG0228	four-way junction DNA binding
TMO_RS16385	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TMO_RS16390	COG0336	Belongs to the RNA methyltransferase TrmD family
TMO_RS16395	COG0335	large ribosomal subunit rRNA binding
TMO_RS16400	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TMO_RS16425	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_RS16440	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TMO_RS16460	COG1960	acyl-CoA dehydrogenase activity
TMO_RS16470	COG0531	amino acid
TMO_RS16480	COG3403	YqcI/YcgG family
TMO_RS16490	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
TMO_RS16500	COG2030	dehydratase
TMO_RS16510	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
TMO_RS16520	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TMO_RS16525	COG1132	(ABC) transporter
TMO_RS16530	COG1132	(ABC) transporter
TMO_RS16530	COG2375	cellular response to nickel ion
TMO_RS16540	COG4771	TonB-dependent receptor
TMO_RS16555	COG0443	Heat shock 70 kDa protein
TMO_RS16560	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TMO_RS16605	COG0583	DNA-binding transcription factor activity
TMO_RS16615	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_RS16625	COG0583	DNA-binding transcription factor activity
TMO_RS16635	COG0288	reversible hydration of carbon dioxide
TMO_RS16640	COG0584	glycerophosphoryl diester phosphodiesterase
TMO_RS16650	COG1175	transmembrane transport
TMO_RS16655	COG0395	ABC-type sugar transport system, permease component
TMO_RS16665	COG0668	transmembrane transport
TMO_RS16680	COG0583	DNA-binding transcription factor activity
TMO_RS16700	COG2095	MarC family integral membrane protein
TMO_RS16705	COG0248	Ppx GppA phosphatase
TMO_RS16710	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TMO_RS16725	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TMO_RS16730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TMO_RS16735	COG3135	benzoate transporter
TMO_RS16745	COG0584	glycerophosphoryl diester phosphodiesterase
TMO_RS16750	COG0045	succinate-CoA ligase (ADP-forming) activity
TMO_RS16750	COG1042	CoA-binding domain protein
TMO_RS16750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TMO_RS16765	COG0167	dihydroorotate dehydrogenase activity
TMO_RS16775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TMO_RS16780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TMO_RS16785	COG0302	gtp cyclohydrolase
TMO_RS16790	COG2967	ApaG domain
TMO_RS16800	COG4136	ATPase activity
TMO_RS16810	COG4134	Bacterial extracellular solute-binding protein
TMO_RS16835	COG0473	3-isopropylmalate dehydrogenase activity
TMO_RS16860	COG0708	Exodeoxyribonuclease III
TMO_RS16870	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TMO_RS16880	COG2814	Major facilitator Superfamily
TMO_RS16900	COG0697	spore germination
TMO_RS16930	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TMO_RS16935	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TMO_RS16940	COG0107	imidazoleglycerol-phosphate synthase activity
TMO_RS16945	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TMO_RS16965	COG3734	2-keto-3-deoxy-galactonokinase
TMO_RS16970	COG0800	Aldolase
TMO_RS16985	COG1858	cytochrome C peroxidase
TMO_RS17015	COG2207	Transcriptional regulator
TMO_RS17050	COG0247	lactate metabolic process
TMO_RS17055	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
TMO_RS17075	COG0367	asparagine synthase
TMO_RS17100	COG3030	protein affecting phage T7 exclusion by the F plasmid
TMO_RS17105	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
TMO_RS17110	COG0583	DNA-binding transcription factor activity
TMO_RS17135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TMO_RS17145	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TMO_RS17150	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TMO_RS17155	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TMO_RS17160	COG1981	membrane
TMO_RS17165	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TMO_RS17185	COG1331	Highly conserved protein containing a thioredoxin domain
TMO_RS17195	COG3411	Ferredoxin
TMO_RS17200	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TMO_RS17205	COG0445	tRNA wobble uridine modification
TMO_RS17270	COG0352	thiamine-phosphate diphosphorylase activity
TMO_RS17305	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TMO_RS17305	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TMO_RS17320	COG0438	transferase activity, transferring glycosyl groups
TMO_RS17330	COG0745	RESPONSE REGULATOR receiver
TMO_RS17345	COG1024	Enoyl-CoA hydratase
TMO_RS17365	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TMO_RS17375	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TMO_RS17380	COG2223	nitrite transmembrane transporter activity
TMO_RS17385	COG1217	gtp-binding protein TYPA
TMO_RS17390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TMO_RS17415	COG2188	Transcriptional regulator
TMO_RS17425	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
TMO_RS17455	COG0792	nuclease activity
TMO_RS17460	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TMO_RS17470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TMO_RS17475	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TMO_RS17480	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TMO_RS17485	COG1420	regulation of RNA biosynthetic process
TMO_RS17490	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TMO_RS17500	COG0484	heat shock protein binding
TMO_RS17505	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TMO_RS17510	COG0697	spore germination
TMO_RS17515	COG3243	poly(R)-hydroxyalkanoic acid synthase
TMO_RS17520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TMO_RS17525	COG0842	Transport permease protein
TMO_RS17525	COG1129	ABC transporter
TMO_RS17530	COG0842	Transport permease protein
TMO_RS17535	COG3550	peptidyl-serine autophosphorylation
TMO_RS17545	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TMO_RS17560	COG4149	molybdate abc transporter
TMO_RS17565	COG1840	ABC-type Fe3 transport system, periplasmic component
TMO_RS17570	COG1609	Transcriptional regulator
TMO_RS17575	COG0728	peptidoglycan biosynthetic process
TMO_RS17590	COG1464	Belongs to the NlpA lipoprotein family
TMO_RS17600	COG0657	acetylesterase activity
TMO_RS17610	COG0392	lysyltransferase activity
TMO_RS17610	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
TMO_RS17625	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TMO_RS17630	COG0281	malic enzyme
TMO_RS17630	COG0280	phosphate acetyltransferase
TMO_RS17635	COG5002	protein histidine kinase activity
TMO_RS17640	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_RS17645	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TMO_RS17650	COG0573	inorganic phosphate transmembrane transporter activity
TMO_RS17670	COG0745	RESPONSE REGULATOR receiver
TMO_RS17675	COG1280	lysine exporter protein (LysE YggA)
TMO_RS17680	COG0180	Tryptophanyl-tRNA synthetase
TMO_RS17685	COG0730	response to heat
TMO_RS17705	COG0789	Transcriptional regulator
TMO_RS17715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TMO_RS17720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TMO_RS17725	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TMO_RS17755	COG1214	PFAM Peptidase M22, glycoprotease
TMO_RS17755	COG0456	acetyltransferase
TMO_RS17785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TMO_RS17790	COG1702	phosphate starvation-inducible protein PhoH
TMO_RS17795	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TMO_RS17800	COG1253	flavin adenine dinucleotide binding
TMO_RS17805	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TMO_RS17810	COG1396	sequence-specific DNA binding
TMO_RS17815	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TMO_RS17820	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TMO_RS17845	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TMO_RS17850	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TMO_RS17855	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TMO_RS17860	COG1185	polyribonucleotide nucleotidyltransferase activity
TMO_RS17900	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TMO_RS17910	COG1959	2 iron, 2 sulfur cluster binding
TMO_RS17920	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TMO_RS17925	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TMO_RS17930	COG2226	methyltransferase
TMO_RS17935	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TMO_RS17945	COG1024	Enoyl-CoA hydratase
TMO_RS17950	COG0268	Binds directly to 16S ribosomal RNA
TMO_RS17970	COG0187	DNA topoisomerase II activity
TMO_RS18725	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TMO_RS18795	COG2962	Rard protein
TMO_RS18810	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TMO_RS18820	COG4133	protoheme IX ABC transporter activity
TMO_RS19050	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TMO_RS19425	COG2204	response regulator
TMO_RS19515	COG4535	Mg2 and Co2 transporter CorC
TMO_RS19825	COG1674	ftsk spoiiie
TMO_RS19890	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TMO_RS19960	COG4774	siderophore transport
TMO_RS19975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TMO_RS20040	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TMO_RS20135	COG2205	protein histidine kinase activity
TMO_RS20240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TMO_RS20240	COG3321	synthase
TMO_RS20240	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_RS20240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TMO_RS20240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TMO_RS20340	COG4191	Histidine kinase
TMO_RS20440	COG1469	GTP cyclohydrolase I activity
TMO_RS20790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TMO_RS21640	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TMO_RS21715	COG0488	(ABC) transporter
TMO_RS22000	COG2267	carboxylic ester hydrolase activity
TMO_RS22030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TMO_RS22275	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TMO_RS22475	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TMO_RS22605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TMO_RS22800	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TMO_RS23135	COG3321	synthase
TMO_RS23135	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_RS23135	COG0604	alcohol dehydrogenase
TMO_RS23270	COG2814	Major facilitator Superfamily
TMO_RS23310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TMO_RS23325	COG1960	acyl-CoA dehydrogenase activity
TMO_RS23400	COG0512	Glutamine amidotransferase of anthranilate synthase
TMO_RS23400	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TMO_RS23790	COG0187	DNA topoisomerase II activity
TMO_RS24590	COG4120	Belongs to the binding-protein-dependent transport system permease family
TMO_RS25110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TMO_RS25860	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TMO_RS25905	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TMO_RS25905	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
TMO_RS25960	COG0156	8-amino-7-oxononanoate synthase activity
TMO_RS26110	COG1304	FMN binding
TMO_RS26175	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TMO_RS27360	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TMO_RS27795	COG1079	Belongs to the binding-protein-dependent transport system permease family
TMO_RS28470	COG3383	formate dehydrogenase (NAD+) activity
TMO_RS28895	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TMO_RS28900	COG0745	RESPONSE REGULATOR receiver
TMO_RS28920	COG2205	protein histidine kinase activity
TMO_RS28920	COG0784	Response regulator, receiver
TMO_RS28920	COG2198	Histidine kinase
TMO_RS28940	COG0668	transmembrane transport
TMO_RS28945	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TMO_RS28970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TMO_RS28975	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
TMO_RS28985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TMO_RS29005	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TMO_RS29035	COG3309	Virulence-associated protein D
TMO_RS29080	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TMO_RS29095	COG2205	protein histidine kinase activity
TMO_RS29095	COG2202	Pas domain
TMO_RS29110	COG2202	Pas domain
TMO_RS29110	COG2205	protein histidine kinase activity
TMO_RS29125	COG2202	Pas domain
TMO_RS29125	COG2205	protein histidine kinase activity
TMO_RS29175	COG1404	Belongs to the peptidase S8 family
TMO_RS29215	COG0437	4 iron, 4 sulfur cluster binding
TMO_RS29235	COG1562	ergosterol biosynthetic process
TMO_RS29250	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TMO_RS29255	COG0829	nickel cation binding
TMO_RS29260	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
TMO_RS29265	COG2861	carbohydrate metabolic process
TMO_RS29285	COG1078	dGTPase activity
TMO_RS29320	COG0784	Response regulator, receiver
TMO_RS29320	COG2205	protein histidine kinase activity
TMO_RS29320	COG2198	Histidine kinase
TMO_RS29330	COG2202	Pas domain
TMO_RS29330	COG2205	protein histidine kinase activity
TMO_RS29330	COG2202	Pas domain
TMO_RS29330	COG2205	protein histidine kinase activity
TMO_RS29340	COG2202	Pas domain
TMO_RS29340	COG2205	protein histidine kinase activity
TMO_RS29350	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TMO_RS29385	COG2271	Major facilitator Superfamily
TMO_RS29440	COG2202	Pas domain
TMO_RS29440	COG2205	protein histidine kinase activity
TMO_RS29490	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TMO_RS29495	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TMO_RS29500	COG3411	Ferredoxin
TMO_RS29505	COG2770	Histidine kinase
TMO_RS29505	COG2208	phosphoserine phosphatase activity
TMO_RS29510	COG1187	pseudouridine synthase activity
TMO_RS29525	COG4585	Histidine kinase
TMO_RS29545	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TMO_RS29565	COG2205	protein histidine kinase activity
TMO_RS29585	COG3128	pkhd-type hydroxylase
TMO_RS29610	COG0463	Glycosyl transferase, family 2
TMO_RS29610	COG1216	Glycosyl transferase, family 2
TMO_RS29625	COG2070	2-Nitropropane dioxygenase
TMO_RS29650	COG2124	cytochrome p450
TMO_RS29660	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
TMO_RS29670	COG1396	sequence-specific DNA binding
TMO_RS29675	COG1396	sequence-specific DNA binding
TMO_RS29780	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TMO_RS29920	COG0583	DNA-binding transcription factor activity
TMO_RS29960	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TMO_RS30120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity