locus-tag	class	description
TOLA_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TOLA_RS00010	COG0592	DNA-directed DNA polymerase activity
TOLA_RS00020	COG0187	DNA topoisomerase II activity
TOLA_RS00025	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TOLA_RS00035	COG3977	Valine--pyruvate aminotransferase
TOLA_RS00040	COG0751	glycine-tRNA ligase activity
TOLA_RS00045	COG0752	glycyl-tRNA synthetase alpha subunit
TOLA_RS00050	COG2818	Glycosylase
TOLA_RS00060	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
TOLA_RS00075	COG4208	sulfate ABC transporter
TOLA_RS00080	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TOLA_RS00085	COG0583	DNA-binding transcription factor activity
TOLA_RS00090	COG0425	Belongs to the sulfur carrier protein TusA family
TOLA_RS00095	COG1653	transport
TOLA_RS00110	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
TOLA_RS00150	COG2801	Transposase and inactivated derivatives
TOLA_RS00165	COG0438	transferase activity, transferring glycosyl groups
TOLA_RS00170	COG0463	Glycosyl transferase, family 2
TOLA_RS00175	COG0859	PFAM glycosyl transferase family 9
TOLA_RS00180	COG0859	PFAM glycosyl transferase family 9
TOLA_RS00185	COG3307	-O-antigen
TOLA_RS00190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TOLA_RS00225	COG3833	ABC-type maltose transport systems, permease component
TOLA_RS00240	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TOLA_RS00245	COG1640	4-alpha-glucanotransferase
TOLA_RS00250	COG0058	SHG alpha-glucan phosphorylase activity
TOLA_RS00255	COG2909	trisaccharide binding
TOLA_RS00260	COG1940	carbohydrate kinase activity
TOLA_RS00275	COG0191	fructose-bisphosphate aldolase activity
TOLA_RS00285	COG1070	Carbohydrate kinase
TOLA_RS00295	COG1172	Belongs to the binding-protein-dependent transport system permease family
TOLA_RS00300	COG1129	ABC transporter
TOLA_RS00315	COG1376	ErfK ybiS ycfS ynhG family protein
TOLA_RS00320	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
TOLA_RS00325	COG1074	ATP-dependent DNA helicase activity
TOLA_RS00330	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TOLA_RS00340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TOLA_RS00350	COG0513	Belongs to the DEAD box helicase family
TOLA_RS00355	COG0513	Belongs to the DEAD box helicase family
TOLA_RS00360	COG1349	DNA-binding transcription factor activity
TOLA_RS00365	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TOLA_RS00370	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TOLA_RS00380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TOLA_RS00410	COG0523	cobalamin synthesis protein
TOLA_RS00420	COG0589	response to stress
TOLA_RS00430	COG2249	NAD(P)H dehydrogenase (quinone) activity
TOLA_RS00435	COG1770	oligopeptidase
TOLA_RS00445	COG0655	NAD(P)H dehydrogenase (quinone) activity
TOLA_RS00460	COG1842	Phage shock protein A
TOLA_RS00465	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TOLA_RS00480	COG2095	MarC family integral membrane protein
TOLA_RS00485	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TOLA_RS00495	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TOLA_RS00500	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TOLA_RS00510	COG0165	Argininosuccinate lyase
TOLA_RS00515	COG0051	transcription antitermination factor activity, RNA binding
TOLA_RS00520	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TOLA_RS00525	COG0088	Forms part of the polypeptide exit tunnel
TOLA_RS00530	COG0089	rRNA binding
TOLA_RS00535	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TOLA_RS00540	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TOLA_RS00545	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TOLA_RS00550	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TOLA_RS00555	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TOLA_RS00560	COG0255	Belongs to the universal ribosomal protein uL29 family
TOLA_RS00565	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TOLA_RS00570	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TOLA_RS00575	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TOLA_RS00580	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TOLA_RS00585	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TOLA_RS00590	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TOLA_RS00595	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TOLA_RS00600	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TOLA_RS00605	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TOLA_RS00610	COG1841	ribosomal large subunit assembly
TOLA_RS00615	COG0200	Binds to the 23S rRNA
TOLA_RS00620	COG0201	protein transport
TOLA_RS00625	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TOLA_RS00630	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TOLA_RS00635	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TOLA_RS00640	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TOLA_RS00645	COG0202	RNA polymerase activity
TOLA_RS00650	COG0203	ribosomal protein L17
TOLA_RS00660	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
TOLA_RS00665	COG0626	cystathionine gamma-synthase activity
TOLA_RS00670	COG0527	aspartate kinase activity
TOLA_RS00670	COG0460	homoserine dehydrogenase
TOLA_RS00680	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TOLA_RS00685	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TOLA_RS00700	COG3642	lipopolysaccharide core region biosynthetic process
TOLA_RS00705	COG1519	Transferase
TOLA_RS00710	COG0683	leucine binding
TOLA_RS00735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TOLA_RS00745	COG3161	chorismate lyase activity
TOLA_RS00750	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TOLA_RS00755	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TOLA_RS00760	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TOLA_RS00770	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TOLA_RS00775	COG0569	domain protein
TOLA_RS00780	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TOLA_RS00780	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TOLA_RS00785	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TOLA_RS00790	COG0242	peptide deformylase activity
TOLA_RS00795	COG1652	LysM domain
TOLA_RS00800	COG0758	DNA mediated transformation
TOLA_RS00805	COG2922	Belongs to the Smg family
TOLA_RS00810	COG0551	DNA topoisomerase type I activity
TOLA_RS00815	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TOLA_RS00820	COG0009	L-threonylcarbamoyladenylate synthase
TOLA_RS00825	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TOLA_RS00830	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TOLA_RS00870	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TOLA_RS00880	COG0366	Alpha amylase catalytic
TOLA_RS00885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TOLA_RS00885	COG1263	PTS System
TOLA_RS00890	COG1609	Transcriptional regulator
TOLA_RS00895	COG2731	YhcH YjgK YiaL family protein
TOLA_RS00905	COG2873	o-acetylhomoserine
TOLA_RS00910	COG0477	Major facilitator Superfamily
TOLA_RS00915	COG0765	amino acid transport
TOLA_RS00920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TOLA_RS00925	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TOLA_RS00930	COG0646	methionine synthase
TOLA_RS00930	COG1410	methionine synthase
TOLA_RS00935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TOLA_RS00945	COG0561	phosphatase activity
TOLA_RS00950	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TOLA_RS00955	COG1758	RNA polymerase activity
TOLA_RS00965	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TOLA_RS00970	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TOLA_RS00975	COG2003	Belongs to the UPF0758 family
TOLA_RS00980	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TOLA_RS00985	COG0756	dUTP diphosphatase activity
TOLA_RS00990	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TOLA_RS00995	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TOLA_RS01000	COG1561	YicC-like family, N-terminal region
TOLA_RS01005	COG1301	dicarboxylic acid transport
TOLA_RS01035	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TOLA_RS01040	COG3123	guanosine phosphorylase activity
TOLA_RS01115	COG0515	serine threonine protein kinase
TOLA_RS01115	COG2815	serine threonine protein kinase
TOLA_RS01125	COG2918	glutathione biosynthetic process
TOLA_RS01130	COG0625	glutathione transferase activity
TOLA_RS01135	COG3493	citrate carrier protein
TOLA_RS01145	COG3290	protein histidine kinase activity
TOLA_RS01150	COG4565	transcriptional regulatory protein
TOLA_RS01160	COG0351	phosphomethylpyrimidine kinase
TOLA_RS01165	COG0352	thiamine-phosphate diphosphorylase activity
TOLA_RS01170	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
TOLA_RS01180	COG1846	Transcriptional regulator
TOLA_RS01180	COG1940	carbohydrate kinase activity
TOLA_RS01190	COG1063	alcohol dehydrogenase
TOLA_RS01195	COG1028	Short-chain dehydrogenase reductase Sdr
TOLA_RS01200	COG2610	gluconate transmembrane transporter activity
TOLA_RS01205	COG1609	Transcriptional regulator
TOLA_RS01210	COG3265	gluconokinase activity
TOLA_RS01215	COG0129	dihydroxy-acid dehydratase activity
TOLA_RS01220	COG0800	Aldolase
TOLA_RS01230	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TOLA_RS01235	COG1181	Belongs to the D-alanine--D-alanine ligase family
TOLA_RS01245	COG0697	spore germination
TOLA_RS01250	COG1011	Hydrolase
TOLA_RS01255	COG0583	DNA-binding transcription factor activity
TOLA_RS01260	COG2814	Major facilitator Superfamily
TOLA_RS01265	COG1490	D-aminoacyl-tRNA deacylase activity
TOLA_RS01280	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TOLA_RS01285	COG3730	PTS system glucitol sorbitol-specific
TOLA_RS01300	COG1028	Short-chain dehydrogenase reductase Sdr
TOLA_RS01310	COG1349	DNA-binding transcription factor activity
TOLA_RS01315	COG1846	Transcriptional regulator
TOLA_RS01320	COG1464	Belongs to the NlpA lipoprotein family
TOLA_RS01325	COG2011	ABC-type metal ion transport system permease component
TOLA_RS01330	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TOLA_RS01340	COG1077	Cell shape determining protein MreB Mrl
TOLA_RS01345	COG1792	Involved in formation and maintenance of cell shape
TOLA_RS01350	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
TOLA_RS01355	COG0424	maF-like protein
TOLA_RS01360	COG1530	ribonuclease E activity
TOLA_RS01365	COG3164	Protein of unknown function
TOLA_RS01370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TOLA_RS01375	COG0312	modulator of DNA gyrase
TOLA_RS01380	COG3028	Belongs to the UPF0307 family
TOLA_RS01385	COG0312	modulator of DNA gyrase
TOLA_RS01390	COG2926	Belongs to the UPF0265 family
TOLA_RS01415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TOLA_RS01420	COG2166	iron-sulfur cluster assembly
TOLA_RS01430	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TOLA_RS01435	COG0463	Glycosyl transferase, family 2
TOLA_RS01445	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TOLA_RS01460	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TOLA_RS01460	COG3008	intermembrane lipid transfer
TOLA_RS01465	COG2995	paraquat-inducible protein a
TOLA_RS01470	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TOLA_RS01480	COG0166	Belongs to the GPI family
TOLA_RS01490	COG2213	PTS system mannitol-specific
TOLA_RS01490	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
TOLA_RS01495	COG0246	Mannitol dehydrogenase
TOLA_RS01500	COG3722	fumarate hydratase activity
TOLA_RS01510	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
TOLA_RS01510	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TOLA_RS01510	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TOLA_RS01515	COG1105	Belongs to the carbohydrate kinase PfkB family
TOLA_RS01520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TOLA_RS01520	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
TOLA_RS01525	COG1609	Transcriptional regulator
TOLA_RS01535	COG0534	Mate efflux family protein
TOLA_RS01540	COG1538	Outer membrane efflux protein
TOLA_RS01550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TOLA_RS01555	COG0697	spore germination
TOLA_RS01560	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TOLA_RS01580	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TOLA_RS01585	COG1349	DNA-binding transcription factor activity
TOLA_RS01590	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TOLA_RS01620	COG1342	Belongs to the UPF0251 family
TOLA_RS01625	COG0730	response to heat
TOLA_RS01630	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TOLA_RS01635	COG0735	belongs to the Fur family
TOLA_RS01645	COG0450	alkyl hydroperoxide reductase
TOLA_RS01695	COG0783	Belongs to the Dps family
TOLA_RS01700	COG0561	phosphatase activity
TOLA_RS01705	COG1968	undecaprenyl-diphosphatase activity
TOLA_RS01750	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TOLA_RS01755	COG3165	ubiquinone biosynthetic process from chorismate
TOLA_RS01760	COG2226	methyltransferase
TOLA_RS01765	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
TOLA_RS01770	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TOLA_RS01770	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TOLA_RS01775	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TOLA_RS01820	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
TOLA_RS01835	COG0501	Belongs to the peptidase M48B family
TOLA_RS01840	COG1704	LemA family
TOLA_RS01845	COG0210	DNA helicase
TOLA_RS01850	COG3158	transport of potassium into the cell
TOLA_RS01865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TOLA_RS01870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TOLA_RS01875	COG1309	transcriptional regulator
TOLA_RS01890	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
TOLA_RS01900	COG3156	type II secretion system protein K
TOLA_RS01905	COG4795	General secretion pathway protein
TOLA_RS01910	COG2165	general secretion pathway protein
TOLA_RS01920	COG2165	general secretion pathway protein
TOLA_RS01925	COG1459	type II secretion system
TOLA_RS01930	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TOLA_RS01935	COG1450	Type ii and iii secretion system protein
TOLA_RS01945	COG3031	protein transport across the cell outer membrane
TOLA_RS01950	COG0494	nUDIX hydrolase
TOLA_RS01980	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TOLA_RS01990	COG1166	arginine decarboxylase activity
TOLA_RS01995	COG0471	metal ion transport
TOLA_RS02000	COG0602	queuosine metabolic process
TOLA_RS02005	COG3338	carbonate dehydratase activity
TOLA_RS02010	COG1560	Kdo2-lipid A biosynthetic process
TOLA_RS02015	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TOLA_RS02015	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TOLA_RS02020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TOLA_RS02025	COG1275	C4-dicarboxylate transporter malic acid transport protein
TOLA_RS02030	COG1538	Outer membrane efflux protein
TOLA_RS02035	COG0842	Transport permease protein
TOLA_RS02040	COG1131	(ABC) transporter
TOLA_RS02045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TOLA_RS02055	COG0494	nUDIX hydrolase
TOLA_RS02060	COG3151	Protein conserved in bacteria
TOLA_RS02065	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TOLA_RS02070	COG3150	esterase
TOLA_RS02085	COG0659	secondary active sulfate transmembrane transporter activity
TOLA_RS02095	COG3630	sodium ion export across plasma membrane
TOLA_RS02105	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TOLA_RS02115	COG0697	spore germination
TOLA_RS02125	COG0247	lactate metabolic process
TOLA_RS02130	COG1105	Belongs to the carbohydrate kinase PfkB family
TOLA_RS02150	COG2271	Major facilitator Superfamily
TOLA_RS02165	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
TOLA_RS02170	COG0179	Fumarylacetoacetate (FAA) hydrolase
TOLA_RS02175	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TOLA_RS02185	COG1328	CTP reductase activity
TOLA_RS02190	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TOLA_RS02195	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TOLA_RS02200	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TOLA_RS02205	COG0625	glutathione transferase activity
TOLA_RS02210	COG2969	positive regulation of protein catabolic process
TOLA_RS02215	COG2823	Periplasmic or secreted lipoprotein
TOLA_RS02220	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TOLA_RS02225	COG0792	nuclease activity
TOLA_RS02230	COG3107	peptidoglycan biosynthetic process
TOLA_RS02235	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TOLA_RS02250	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
TOLA_RS02260	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
TOLA_RS02265	COG1169	isochorismate synthase
TOLA_RS02270	COG1575	Belongs to the MenA family. Type 1 subfamily
TOLA_RS02275	COG1280	lysine exporter protein (LysE YggA)
TOLA_RS02280	COG3078	GTPase activator activity
TOLA_RS02290	COG1609	Transcriptional regulator
TOLA_RS02295	COG1349	DNA-binding transcription factor activity
TOLA_RS02300	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TOLA_RS02305	COG1760	l-serine dehydratase
TOLA_RS02310	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TOLA_RS02310	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TOLA_RS02310	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TOLA_RS02315	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TOLA_RS02325	COG2207	Transcriptional regulator
TOLA_RS02330	COG3133	Outer membrane lipoprotein
TOLA_RS02335	COG1940	carbohydrate kinase activity
TOLA_RS02340	COG1447	Phosphotransferase system cellobiose-specific component IIA
TOLA_RS02345	COG2723	6-phospho-beta-galactosidase activity
TOLA_RS02350	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TOLA_RS02350	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TOLA_RS02355	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TOLA_RS02360	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TOLA_RS02365	COG1609	Transcriptional regulator
TOLA_RS02370	COG2204	response regulator
TOLA_RS02375	COG3852	Histidine kinase
TOLA_RS02385	COG0174	glutamine synthetase
TOLA_RS02390	COG1217	gtp-binding protein TYPA
TOLA_RS02395	COG1295	ribonuclease BN
TOLA_RS02415	COG0586	Pfam SNARE associated Golgi protein
TOLA_RS02420	COG2814	Major facilitator Superfamily
TOLA_RS02435	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TOLA_RS02440	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TOLA_RS02445	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TOLA_RS02460	COG1595	DNA-templated transcription, initiation
TOLA_RS02465	COG3806	Anti-sigma factor
TOLA_RS02475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TOLA_RS02490	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TOLA_RS02495	COG0254	rRNA binding
TOLA_RS02500	COG0281	malic enzyme
TOLA_RS02505	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
TOLA_RS02510	COG1494	fructose-1,6-bisphosphatase
TOLA_RS02525	COG0070	glutamate synthase
TOLA_RS02525	COG0067	glutamate synthase
TOLA_RS02525	COG0069	glutamate synthase activity
TOLA_RS02530	COG0583	DNA-binding transcription factor activity
TOLA_RS02535	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
TOLA_RS02540	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TOLA_RS02545	COG1611	Belongs to the LOG family
TOLA_RS02555	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TOLA_RS02555	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TOLA_RS02580	COG0564	pseudouridine synthase activity
TOLA_RS02590	COG2116	formate transmembrane transporter activity
TOLA_RS02595	COG2146	nitrite reductase [NAD(P)H] activity
TOLA_RS02600	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TOLA_RS02605	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TOLA_RS02610	COG1151	hydroxylamine reductase activity
TOLA_RS02615	COG4942	peptidase
TOLA_RS02620	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TOLA_RS02625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TOLA_RS02630	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
TOLA_RS02635	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TOLA_RS02640	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TOLA_RS02640	COG0316	Belongs to the HesB IscA family
TOLA_RS02650	COG0004	ammonium transporteR
TOLA_RS02655	COG0596	Alpha beta hydrolase
TOLA_RS02660	COG2183	response to ionizing radiation
TOLA_RS02665	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TOLA_RS02675	COG2001	Belongs to the MraZ family
TOLA_RS02680	COG0275	rRNA processing
TOLA_RS02685	COG3116	cell division
TOLA_RS02690	COG0768	penicillin binding
TOLA_RS02695	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TOLA_RS02700	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TOLA_RS02705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TOLA_RS02715	COG0772	Belongs to the SEDS family
TOLA_RS02720	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TOLA_RS02725	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TOLA_RS02730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TOLA_RS02735	COG0849	cell division
TOLA_RS02740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TOLA_RS02745	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TOLA_RS02750	COG0653	protein targeting
TOLA_RS02755	COG0494	nUDIX hydrolase
TOLA_RS02760	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
TOLA_RS02770	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TOLA_RS02775	COG1459	type II secretion system
TOLA_RS02780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TOLA_RS02795	COG0138	bifunctional purine biosynthesis protein purh
TOLA_RS02810	COG2026	Addiction module toxin, RelE StbE family
TOLA_RS02820	COG0488	(ABC) transporter
TOLA_RS02835	COG0795	lipopolysaccharide-transporting ATPase activity
TOLA_RS02840	COG0795	lipopolysaccharide-transporting ATPase activity
TOLA_RS02845	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TOLA_RS02850	COG2927	DNA polymerase III (CHI subunit)
TOLA_RS02860	COG0583	DNA-binding transcription factor activity
TOLA_RS02865	COG3038	cytochrome b561
TOLA_RS02875	COG2353	YceI-like domain
TOLA_RS02880	COG1741	Belongs to the pirin family
TOLA_RS02885	COG2195	Cleaves the N-terminal amino acid of tripeptides
TOLA_RS02890	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TOLA_RS02905	COG4948	Mandelate Racemase Muconate Lactonizing
TOLA_RS02915	COG1115	amino acid carrier protein
TOLA_RS02930	COG1278	Cold shock
TOLA_RS02935	COG1418	mRNA catabolic process
TOLA_RS02940	COG1869	D-ribose catabolic process
TOLA_RS02945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TOLA_RS02950	COG1869	D-ribose catabolic process
TOLA_RS02960	COG1172	Belongs to the binding-protein-dependent transport system permease family
TOLA_RS02965	COG1879	ABC-type sugar transport system periplasmic component
TOLA_RS02970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TOLA_RS02975	COG1609	Transcriptional regulator
TOLA_RS02980	COG1397	ADP-ribosylglycohydrolase
TOLA_RS02990	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TOLA_RS02995	COG0316	Belongs to the HesB IscA family
TOLA_RS03005	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
TOLA_RS03010	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TOLA_RS03030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TOLA_RS03030	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TOLA_RS03040	COG2217	Heavy metal translocating P-type atpase
TOLA_RS03055	COG0842	Transport permease protein
TOLA_RS03060	COG0842	Transport permease protein
TOLA_RS03060	COG1129	ABC transporter
TOLA_RS03065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TOLA_RS03080	COG0247	lactate metabolic process
TOLA_RS03080	COG0277	FAD linked oxidase domain protein
TOLA_RS03085	COG2050	protein possibly involved in aromatic compounds catabolism
TOLA_RS03095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TOLA_RS03095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TOLA_RS03100	COG0259	pyridoxamine-phosphate oxidase activity
TOLA_RS03105	COG3264	Mechanosensitive ion channel
TOLA_RS03105	COG1196	nuclear chromosome segregation
TOLA_RS03110	COG0469	pyruvate kinase activity
TOLA_RS03150	COG0028	Belongs to the TPP enzyme family
TOLA_RS03175	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TOLA_RS03180	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TOLA_RS03185	COG1242	4 iron, 4 sulfur cluster binding
TOLA_RS03190	COG0784	Response regulator, receiver
TOLA_RS03190	COG2198	Histidine kinase
TOLA_RS03190	COG5002	protein histidine kinase activity
TOLA_RS03195	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TOLA_RS03205	COG0745	RESPONSE REGULATOR receiver
TOLA_RS03215	COG0083	homoserine kinase activity
TOLA_RS03220	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TOLA_RS03225	COG2190	(PTS) system
TOLA_RS03230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TOLA_RS03235	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TOLA_RS03245	COG2989	Protein conserved in bacteria
TOLA_RS03255	COG3115	cell septum assembly
TOLA_RS03260	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TOLA_RS03265	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TOLA_RS03265	COG0047	phosphoribosylformylglycinamidine synthase activity
TOLA_RS03270	COG0791	NLP P60 protein
TOLA_RS03295	COG0788	formyltetrahydrofolate deformylase activity
TOLA_RS03315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TOLA_RS03340	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
TOLA_RS03345	COG0366	Alpha amylase catalytic
TOLA_RS03350	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
TOLA_RS03390	COG3383	formate dehydrogenase (NAD+) activity
TOLA_RS03415	COG2161	toxin-antitoxin pair type II binding
TOLA_RS03435	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TOLA_RS03440	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
TOLA_RS03445	COG1178	ABC-type Fe3 transport system permease component
TOLA_RS03450	COG4143	(ABC) transporter
TOLA_RS03465	COG4178	(ABC) transporter
TOLA_RS03470	COG4604	ABC transporter, ATP-binding protein
TOLA_RS03475	COG4605	iron ion homeostasis
TOLA_RS03480	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TOLA_RS03485	COG4607	ABC-type enterochelin transport system periplasmic component
TOLA_RS03495	COG0066	3-isopropylmalate dehydratase activity
TOLA_RS03500	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TOLA_RS03505	COG0473	3-isopropylmalate dehydrogenase activity
TOLA_RS03510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TOLA_RS03515	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
TOLA_RS03520	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TOLA_RS03535	COG4807	Protein conserved in bacteria
TOLA_RS03540	COG2824	Alkylphosphonate utilization operon protein PhnA
TOLA_RS03545	COG2501	S4 domain
TOLA_RS03550	COG4628	conserved protein (DUF2132)
TOLA_RS03595	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TOLA_RS03615	COG2801	Transposase and inactivated derivatives
TOLA_RS03705	COG0776	regulation of translation
TOLA_RS03775	COG0640	Transcriptional regulator
TOLA_RS03785	COG4373	Mu-like prophage FluMu protein gp28
TOLA_RS03790	COG4383	Mu-like prophage protein gp29
TOLA_RS03810	COG4388	Caudovirus prohead serine protease
TOLA_RS03815	COG4397	Mu-like prophage major head subunit gpT
TOLA_RS03895	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TOLA_RS03905	COG0537	adenosine 5'-monophosphoramidase activity
TOLA_RS03920	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TOLA_RS03930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TOLA_RS03945	COG1286	toxin biosynthetic process
TOLA_RS03950	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TOLA_RS03965	COG0783	Belongs to the Dps family
TOLA_RS03975	COG1609	Transcriptional regulator
TOLA_RS03980	COG0800	Aldolase
TOLA_RS03990	COG3265	gluconokinase activity
TOLA_RS03995	COG2610	gluconate transmembrane transporter activity
TOLA_RS04000	COG1253	flavin adenine dinucleotide binding
TOLA_RS04025	COG0500	methyltransferase
TOLA_RS04030	COG4106	trans-aconitate 2-methyltransferase activity
TOLA_RS04035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TOLA_RS04040	COG0583	DNA-binding transcription factor activity
TOLA_RS04050	COG1643	Atp-dependent helicase
TOLA_RS04055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TOLA_RS04065	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TOLA_RS04070	COG1666	GTP binding
TOLA_RS04075	COG2814	Major facilitator Superfamily
TOLA_RS04090	COG2813	Specifically methylates the guanine in position
TOLA_RS04100	COG0271	Belongs to the BolA IbaG family
TOLA_RS04110	COG4989	oxidoreductase activity
TOLA_RS04115	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TOLA_RS04120	COG2195	Cleaves the N-terminal amino acid of tripeptides
TOLA_RS04135	COG0737	Belongs to the 5'-nucleotidase family
TOLA_RS04140	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
TOLA_RS04145	COG1073	alpha beta
TOLA_RS04155	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TOLA_RS04180	COG1131	(ABC) transporter
TOLA_RS04185	COG0842	Transport permease protein
TOLA_RS04195	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TOLA_RS04200	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
TOLA_RS04205	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TOLA_RS04210	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TOLA_RS04215	COG2890	protein-(glutamine-N5) methyltransferase activity
TOLA_RS04220	COG2912	Transglutaminase-like superfamily
TOLA_RS04235	COG0442	prolyl-tRNA aminoacylation
TOLA_RS04240	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TOLA_RS04250	COG1720	tRNA m6t6A37 methyltransferase activity
TOLA_RS04260	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
TOLA_RS04265	COG4988	ABC transporter
TOLA_RS04305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TOLA_RS04305	COG1263	PTS System
TOLA_RS04310	COG1263	PTS System
TOLA_RS04310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TOLA_RS04315	COG0354	folic acid binding
TOLA_RS04325	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TOLA_RS04330	COG1595	DNA-templated transcription, initiation
TOLA_RS04350	COG0481	GTPase activity
TOLA_RS04360	COG0571	ribonuclease III activity
TOLA_RS04370	COG1381	Involved in DNA repair and RecF pathway recombination
TOLA_RS04385	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
TOLA_RS04390	COG0488	(ABC) transporter
TOLA_RS04395	COG1047	Peptidyl-prolyl cis-trans
TOLA_RS04400	COG0735	belongs to the Fur family
TOLA_RS04405	COG0716	FMN binding
TOLA_RS04415	COG0596	Alpha beta hydrolase
TOLA_RS04420	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
TOLA_RS04430	COG4172	Belongs to the ABC transporter superfamily
TOLA_RS04440	COG4171	peptide transport system, permease
TOLA_RS04445	COG4168	peptide transport system, permease
TOLA_RS04455	COG3106	COG3106 Predicted ATPase
TOLA_RS04460	COG3768	UPF0283 membrane protein
TOLA_RS04465	COG2205	protein histidine kinase activity
TOLA_RS04470	COG0745	RESPONSE REGULATOR receiver
TOLA_RS04475	COG2755	lipolytic protein G-D-S-L family
TOLA_RS04480	COG4181	ATPase activity
TOLA_RS04485	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
TOLA_RS04490	COG1090	epimerase
TOLA_RS04500	COG0280	phosphate acetyltransferase
TOLA_RS04500	COG0857	belongs to the CobB CobQ family
TOLA_RS04510	COG3092	negative regulation of chromosome organization
TOLA_RS04515	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TOLA_RS04520	COG1882	Formate acetyltransferase
TOLA_RS04525	COG2116	formate transmembrane transporter activity
TOLA_RS04530	COG1944	ATP diphosphatase activity
TOLA_RS04535	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TOLA_RS04540	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TOLA_RS04550	COG1426	Protein conserved in bacteria
TOLA_RS04560	COG0124	histidyl-tRNA synthetase
TOLA_RS04565	COG2976	Protein conserved in bacteria
TOLA_RS04570	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TOLA_RS04575	COG1160	GTP binding
TOLA_RS04590	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
TOLA_RS04620	COG4160	amino acid transport
TOLA_RS04630	COG0708	Exodeoxyribonuclease III
TOLA_RS04645	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TOLA_RS04660	COG0300	oxidoreductase activity
TOLA_RS04665	COG0741	lytic transglycosylase activity
TOLA_RS04665	COG1388	LysM domain
TOLA_RS04670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TOLA_RS04675	COG2226	methyltransferase
TOLA_RS04680	COG0328	RNA-DNA hybrid ribonuclease activity
TOLA_RS04690	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TOLA_RS04695	COG0121	glutamine amidotransferase
TOLA_RS04700	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TOLA_RS04705	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TOLA_RS04710	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TOLA_RS04720	COG4783	chaperone-mediated protein folding
TOLA_RS04725	COG0628	permease
TOLA_RS04730	COG3118	belongs to the thioredoxin family
TOLA_RS04735	COG2091	lysine biosynthetic process via aminoadipic acid
TOLA_RS04740	COG3083	sulfuric ester hydrolase activity
TOLA_RS04745	COG3082	Protein of unknown function (DUF1414)
TOLA_RS04750	COG3081	Nucleoid-associated protein
TOLA_RS04755	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TOLA_RS04770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TOLA_RS04775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TOLA_RS04795	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TOLA_RS04800	COG1555	photosystem II stabilization
TOLA_RS04805	COG1218	3'(2'),5'-bisphosphate nucleotidase
TOLA_RS04810	COG2350	Protein conserved in bacteria
TOLA_RS04815	COG2917	probably involved in intracellular septation
TOLA_RS04820	COG0159	tryptophan synthase activity
TOLA_RS04825	COG0133	tryptophan synthase activity
TOLA_RS04830	COG0135	phosphoribosylanthranilate isomerase activity
TOLA_RS04830	COG0134	indole-3-glycerol-phosphate synthase activity
TOLA_RS04835	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TOLA_RS04840	COG0512	Glutamine amidotransferase of anthranilate synthase
TOLA_RS04840	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TOLA_RS04845	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TOLA_RS04855	COG0009	L-threonylcarbamoyladenylate synthase
TOLA_RS04865	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TOLA_RS04870	COG1956	GAF domain-containing protein
TOLA_RS04905	COG2204	response regulator
TOLA_RS04925	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
TOLA_RS04930	COG1194	a g-specific adenine glycosylase
TOLA_RS04935	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TOLA_RS04940	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TOLA_RS04945	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TOLA_RS04950	COG1872	DUF167
TOLA_RS04955	COG0762	integral membrane protein
TOLA_RS04960	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TOLA_RS04965	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TOLA_RS04980	COG3022	response to hydroperoxide
TOLA_RS04985	COG0513	Belongs to the DEAD box helicase family
TOLA_RS04990	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
TOLA_RS04995	COG0716	FMN binding
TOLA_RS05000	COG4974	Belongs to the 'phage' integrase family
TOLA_RS05010	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TOLA_RS05015	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TOLA_RS05020	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TOLA_RS05025	COG0488	(ABC) transporter
TOLA_RS05030	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TOLA_RS05040	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TOLA_RS05080	COG2723	6-phospho-beta-galactosidase activity
TOLA_RS05085	COG0583	DNA-binding transcription factor activity
TOLA_RS05090	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TOLA_RS05100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TOLA_RS05105	COG4136	ATPase activity
TOLA_RS05110	COG4135	transport system, permease component
TOLA_RS05115	COG4134	Bacterial extracellular solute-binding protein
TOLA_RS05120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TOLA_RS05130	COG0604	alcohol dehydrogenase
TOLA_RS05135	COG1309	transcriptional regulator
TOLA_RS05145	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TOLA_RS05145	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TOLA_RS05155	COG0671	phosphoesterase, PA-phosphatase related
TOLA_RS05175	COG0701	Predicted permease
TOLA_RS05185	COG0798	PFAM Bile acid sodium symporter
TOLA_RS05190	COG2832	Protein of unknown function (DUF454)
TOLA_RS05205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TOLA_RS05215	COG1175	transmembrane transport
TOLA_RS05220	COG0395	ABC-type sugar transport system, permease component
TOLA_RS05225	COG1621	beta-fructofuranosidase activity
TOLA_RS05235	COG1609	Transcriptional regulator
TOLA_RS05245	COG0469	pyruvate kinase activity
TOLA_RS05250	COG1737	Transcriptional regulator
TOLA_RS05255	COG0837	glucose binding
TOLA_RS05265	COG0501	Belongs to the peptidase M48B family
TOLA_RS05270	COG0545	Peptidyl-prolyl cis-trans isomerase
TOLA_RS05275	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TOLA_RS05280	COG0505	Belongs to the CarA family
TOLA_RS05285	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TOLA_RS05305	COG1538	Outer membrane efflux protein
TOLA_RS05310	COG1566	PFAM secretion protein HlyD family protein
TOLA_RS05315	COG2814	Major facilitator Superfamily
TOLA_RS05320	COG0235	Class ii aldolase
TOLA_RS05350	COG3254	rhamnose metabolic process
TOLA_RS05360	COG4806	L-rhamnose isomerase
TOLA_RS05365	COG1070	Carbohydrate kinase
TOLA_RS05375	COG1454	alcohol dehydrogenase
TOLA_RS05380	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TOLA_RS05385	COG2719	SpoVR family
TOLA_RS05390	COG2718	Belongs to the UPF0229 family
TOLA_RS05395	COG2766	serine protein kinase
TOLA_RS05400	COG0058	SHG alpha-glucan phosphorylase activity
TOLA_RS05405	COG0307	riboflavin synthase, alpha
TOLA_RS05410	COG0513	Belongs to the DEAD box helicase family
TOLA_RS05440	COG2801	Transposase and inactivated derivatives
TOLA_RS05460	COG1011	Hydrolase
TOLA_RS05470	COG3040	lipid binding
TOLA_RS05485	COG1199	ATP-dependent helicase activity
TOLA_RS05495	COG3065	identical protein binding
TOLA_RS05500	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TOLA_RS05510	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TOLA_RS05530	COG1366	Belongs to the anti-sigma-factor antagonist family
TOLA_RS05535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TOLA_RS05540	COG0544	peptidyl-prolyl cis-trans isomerase activity
TOLA_RS05545	COG0740	serine-type endopeptidase activity
TOLA_RS05550	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TOLA_RS05555	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TOLA_RS05560	COG0776	regulation of translation
TOLA_RS05565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TOLA_RS05570	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
TOLA_RS05575	COG0793	Belongs to the peptidase S41A family
TOLA_RS05580	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
TOLA_RS05585	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TOLA_RS05590	COG0017	Asparaginyl-tRNA synthetase
TOLA_RS05600	COG1486	melibiose metabolic process
TOLA_RS05605	COG0583	DNA-binding transcription factor activity
TOLA_RS05615	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TOLA_RS05620	COG0156	8-amino-7-oxononanoate synthase activity
TOLA_RS05630	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TOLA_RS05635	COG0501	Belongs to the peptidase M48B family
TOLA_RS05640	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TOLA_RS05645	COG0729	surface antigen
TOLA_RS05665	COG1012	belongs to the aldehyde dehydrogenase family
TOLA_RS05675	COG1177	transmembrane transport
TOLA_RS05680	COG1176	ABC-type spermidine putrescine transport system, permease component I
TOLA_RS05690	COG3842	ATPase activity
TOLA_RS05700	COG3272	Protein of unknown function (DUF1722)
TOLA_RS05705	COG0415	Belongs to the DNA photolyase family
TOLA_RS05730	COG0556	nucleotide-excision repair
TOLA_RS05735	COG0302	gtp cyclohydrolase
TOLA_RS05740	COG2925	Exonuclease
TOLA_RS05750	COG2391	methyltransferase activity
TOLA_RS05755	COG3013	Belongs to the UPF0304 family
TOLA_RS05765	COG0463	Glycosyl transferase, family 2
TOLA_RS05780	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TOLA_RS05785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TOLA_RS05795	COG1876	peptidase activity
TOLA_RS05800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TOLA_RS05805	COG1393	Belongs to the ArsC family
TOLA_RS05830	COG1979	alcohol dehydrogenase
TOLA_RS05860	COG2003	Belongs to the UPF0758 family
TOLA_RS05915	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TOLA_RS05920	COG0732	type I restriction modification DNA specificity domain
TOLA_RS05965	COG1160	GTP binding
TOLA_RS05970	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TOLA_RS05985	COG4983	Phage plasmid primase, P4 family domain protein
TOLA_RS05995	COG0582	viral genome integration into host DNA
TOLA_RS06000	COG1414	Transcriptional regulator
TOLA_RS06005	COG4948	Mandelate Racemase Muconate Lactonizing
TOLA_RS06010	COG2271	Major facilitator Superfamily
TOLA_RS06020	COG1454	alcohol dehydrogenase
TOLA_RS06035	COG4804	nuclease activity
TOLA_RS06055	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TOLA_RS06065	COG0210	DNA helicase
TOLA_RS06085	COG3706	GGDEF domain
TOLA_RS06095	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TOLA_RS06100	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
TOLA_RS06105	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
TOLA_RS06110	COG2205	protein histidine kinase activity
TOLA_RS06115	COG0745	RESPONSE REGULATOR receiver
TOLA_RS06155	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TOLA_RS06160	COG1342	Belongs to the UPF0251 family
TOLA_RS06165	COG0735	belongs to the Fur family
TOLA_RS06190	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TOLA_RS06210	COG0861	Integral membrane protein TerC family
TOLA_RS06225	COG2920	part of a sulfur-relay system
TOLA_RS06230	COG1289	transmembrane transporter activity
TOLA_RS06240	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TOLA_RS06245	COG0732	type I restriction modification DNA specificity domain
TOLA_RS06255	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TOLA_RS06270	COG0564	pseudouridine synthase activity
TOLA_RS06275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TOLA_RS06280	COG4597	amino acid ABC transporter
TOLA_RS06285	COG0765	amino acid transport
TOLA_RS06290	COG1126	abc transporter atp-binding protein
TOLA_RS06295	COG0366	Alpha amylase catalytic
TOLA_RS06300	COG0366	Alpha amylase catalytic
TOLA_RS06305	COG3842	ATPase activity
TOLA_RS06320	COG1653	transport
TOLA_RS06325	COG0583	DNA-binding transcription factor activity
TOLA_RS06330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TOLA_RS06330	COG1263	PTS System
TOLA_RS06340	COG1028	Short-chain dehydrogenase reductase Sdr
TOLA_RS06365	COG4591	ABC-type transport system involved in lipoprotein release permease component
TOLA_RS06370	COG1136	(ABC) transporter
TOLA_RS06370	COG0577	efflux transmembrane transporter activity
TOLA_RS06375	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TOLA_RS06380	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TOLA_RS06385	COG1678	Uncharacterized ACR, COG1678
TOLA_RS06390	COG0189	ligase activity
TOLA_RS06395	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TOLA_RS06410	COG3091	SprT-like family
TOLA_RS06415	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TOLA_RS06420	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TOLA_RS06425	COG0126	phosphoglycerate kinase activity
TOLA_RS06430	COG0191	fructose-bisphosphate aldolase activity
TOLA_RS06435	COG1132	(ABC) transporter
TOLA_RS06440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TOLA_RS06480	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TOLA_RS06495	COG0306	phosphate transporter
TOLA_RS06505	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
TOLA_RS06510	COG1368	sulfuric ester hydrolase activity
TOLA_RS06520	COG1643	Atp-dependent helicase
TOLA_RS06530	COG1278	Cold shock
TOLA_RS06535	COG1132	(ABC) transporter
TOLA_RS06540	COG1132	(ABC) transporter
TOLA_RS06545	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
TOLA_RS06555	COG1970	mechanosensitive ion channel activity
TOLA_RS06570	COG0469	pyruvate kinase activity
TOLA_RS06580	COG1253	flavin adenine dinucleotide binding
TOLA_RS06620	COG1280	lysine exporter protein (LysE YggA)
TOLA_RS06630	COG1280	lysine exporter protein (LysE YggA)
TOLA_RS06640	COG0564	pseudouridine synthase activity
TOLA_RS06655	COG0697	spore germination
TOLA_RS06675	COG2897	thiosulfate sulfurtransferase activity
TOLA_RS06705	COG2996	Protein conserved in bacteria
TOLA_RS06715	COG4681	YaeQ
TOLA_RS06720	COG0673	inositol 2-dehydrogenase activity
TOLA_RS06730	COG0574	Belongs to the PEP-utilizing enzyme family
TOLA_RS06730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TOLA_RS06740	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TOLA_RS06740	COG1017	nitric oxide dioxygenase activity
TOLA_RS06750	COG1322	Protein conserved in bacteria
TOLA_RS06775	COG2272	Belongs to the type-B carboxylesterase lipase family
TOLA_RS06780	COG2272	Belongs to the type-B carboxylesterase lipase family
TOLA_RS06785	COG0667	Aldo Keto reductase
TOLA_RS06805	COG0656	L-ascorbic acid biosynthetic process
TOLA_RS06825	COG0395	ABC-type sugar transport system, permease component
TOLA_RS06850	COG0531	amino acid
TOLA_RS06860	COG4702	Belongs to the UPF0303 family
TOLA_RS06885	COG0628	permease
TOLA_RS06900	COG1127	ABC transporter
TOLA_RS06905	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TOLA_RS06910	COG1136	(ABC) transporter
TOLA_RS06920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TOLA_RS06935	COG1518	maintenance of DNA repeat elements
TOLA_RS06940	COG1203	CRISPR-associated helicase, Cas3
TOLA_RS06970	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TOLA_RS06975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TOLA_RS06985	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TOLA_RS06990	COG1966	Carbon starvation protein
TOLA_RS06995	COG3279	Response regulator of the LytR AlgR family
TOLA_RS07000	COG3275	phosphorelay sensor kinase activity
TOLA_RS07005	COG1744	ABC transporter substrate-binding protein PnrA-like
TOLA_RS07010	COG3845	ABC transporter
TOLA_RS07015	COG4603	Belongs to the binding-protein-dependent transport system permease family
TOLA_RS07020	COG1079	Belongs to the binding-protein-dependent transport system permease family
TOLA_RS07025	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TOLA_RS07030	COG1605	Chorismate mutase
TOLA_RS07030	COG0287	Prephenate dehydrogenase
TOLA_RS07040	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TOLA_RS07050	COG0583	DNA-binding transcription factor activity
TOLA_RS07055	COG0616	signal peptide processing
TOLA_RS07080	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TOLA_RS07085	COG2204	response regulator
TOLA_RS07100	COG0513	Belongs to the DEAD box helicase family
TOLA_RS07105	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TOLA_RS07110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TOLA_RS07115	COG0534	Mate efflux family protein
TOLA_RS07140	COG1187	pseudouridine synthase activity
TOLA_RS07145	COG1739	Uncharacterized protein family UPF0029
TOLA_RS07190	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TOLA_RS07210	COG3420	alginic acid biosynthetic process
TOLA_RS07225	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
TOLA_RS07225	COG0662	Cupin 2, conserved barrel domain protein
TOLA_RS07250	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TOLA_RS07250	COG0116	Belongs to the methyltransferase superfamily
TOLA_RS07255	COG0488	(ABC) transporter
TOLA_RS07265	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TOLA_RS07270	COG1067	ATP-dependent peptidase activity
TOLA_RS07275	COG3148	PFAM DTW domain containing protein
TOLA_RS07295	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TOLA_RS07320	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TOLA_RS07325	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TOLA_RS07340	COG0583	DNA-binding transcription factor activity
TOLA_RS07345	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TOLA_RS07350	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TOLA_RS07360	COG0346	lactoylglutathione lyase activity
TOLA_RS07365	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TOLA_RS07375	COG4659	FMN binding
TOLA_RS07380	COG4658	electron transport chain
TOLA_RS07385	COG4656	Part of a membrane complex involved in electron transport
TOLA_RS07390	COG2878	Part of a membrane complex involved in electron transport
TOLA_RS07395	COG4657	Part of a membrane complex involved in electron transport
TOLA_RS07410	COG1451	nucleotide metabolic process
TOLA_RS07415	COG4628	conserved protein (DUF2132)
TOLA_RS07420	COG0730	response to heat
TOLA_RS07425	COG3593	DNA synthesis involved in DNA repair
TOLA_RS07430	COG0205	6-phosphofructokinase activity
TOLA_RS07440	COG1434	Gram-negative-bacterium-type cell wall biogenesis
TOLA_RS07445	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TOLA_RS07455	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
TOLA_RS07465	COG5433	transposase activity
TOLA_RS07480	COG1448	Aminotransferase
TOLA_RS07490	COG1079	Belongs to the binding-protein-dependent transport system permease family
TOLA_RS07495	COG4603	Belongs to the binding-protein-dependent transport system permease family
TOLA_RS07500	COG3845	ABC transporter
TOLA_RS07505	COG0210	DNA helicase
TOLA_RS07510	COG2223	nitrite transmembrane transporter activity
TOLA_RS07515	COG2862	Uncharacterized protein family, UPF0114
TOLA_RS07525	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TOLA_RS07540	COG1994	Peptidase M50
TOLA_RS07555	COG2723	6-phospho-beta-galactosidase activity
TOLA_RS07565	COG0137	argininosuccinate synthase activity
TOLA_RS07570	COG1120	ATPase activity
TOLA_RS07575	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TOLA_RS07590	COG4615	Cyclic peptide transporter
TOLA_RS07600	COG0583	DNA-binding transcription factor activity
TOLA_RS07605	COG1979	alcohol dehydrogenase
TOLA_RS07610	COG0589	response to stress
TOLA_RS07615	COG0659	secondary active sulfate transmembrane transporter activity
TOLA_RS07620	COG1902	pentaerythritol trinitrate reductase activity
TOLA_RS07625	COG0583	DNA-binding transcription factor activity
TOLA_RS07630	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TOLA_RS07640	COG2272	Belongs to the type-B carboxylesterase lipase family
TOLA_RS07650	COG0667	Aldo Keto reductase
TOLA_RS07670	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TOLA_RS07700	COG0579	oxidoreductase
TOLA_RS07715	COG2951	lytic endotransglycosylase activity
TOLA_RS07730	COG0667	Aldo Keto reductase
TOLA_RS07750	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TOLA_RS07760	COG1448	Aminotransferase
TOLA_RS07765	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TOLA_RS07775	COG1349	DNA-binding transcription factor activity
TOLA_RS07780	COG0717	Belongs to the dCTP deaminase family
TOLA_RS07785	COG0572	uridine kinase
TOLA_RS07790	COG0489	protein tyrosine kinase activity
TOLA_RS07795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TOLA_RS07795	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TOLA_RS07805	COG2850	peptidyl-arginine hydroxylation
TOLA_RS07815	COG0531	amino acid
TOLA_RS07820	COG4303	Ethanolamine ammonia lyase large subunit
TOLA_RS07830	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TOLA_RS07835	COG1584	GPR1 FUN34 yaaH family protein
TOLA_RS07840	COG1252	NADH dehydrogenase
TOLA_RS07845	COG3150	esterase
TOLA_RS07850	COG1472	Belongs to the glycosyl hydrolase 3 family
TOLA_RS07855	COG1605	Chorismate mutase
TOLA_RS07855	COG0077	Prephenate dehydratase
TOLA_RS07865	COG0167	dihydroorotate dehydrogenase activity
TOLA_RS07870	COG0308	aminopeptidase N
TOLA_RS07875	COG2197	response regulator
TOLA_RS07880	COG0322	excinuclease ABC activity
TOLA_RS07910	COG2916	Histone family protein nucleoid-structuring protein H-NS
TOLA_RS07920	COG0284	orotidine-5'-phosphate decarboxylase activity
TOLA_RS07925	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
TOLA_RS07935	COG0776	regulation of translation
TOLA_RS07940	COG0539	negative regulation of cytoplasmic translation
TOLA_RS07945	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TOLA_RS07950	COG2983	Belongs to the UPF0260 family
TOLA_RS07955	COG0850	regulation of cytokinetic process
TOLA_RS07960	COG2894	cell division
TOLA_RS07965	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TOLA_RS07970	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
TOLA_RS07975	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TOLA_RS07980	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
TOLA_RS07985	COG0285	dihydrofolate synthase activity
TOLA_RS07990	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TOLA_RS07995	COG0101	tRNA pseudouridine synthase activity
TOLA_RS08005	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TOLA_RS08010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TOLA_RS08020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TOLA_RS08020	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TOLA_RS08035	COG0114	fumarate hydratase activity
TOLA_RS08040	COG4598	ABC transporter
TOLA_RS08045	COG4160	amino acid transport
TOLA_RS08050	COG4215	(ABC) transporter
TOLA_RS08060	COG1051	belongs to the nudix hydrolase family
TOLA_RS08065	COG3036	rescue of stalled ribosome
TOLA_RS08105	COG0556	nucleotide-excision repair
TOLA_RS08110	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TOLA_RS08120	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TOLA_RS08180	COG4584	PFAM Integrase catalytic
TOLA_RS08185	COG1484	DNA-dependent DNA replication
TOLA_RS08195	COG0210	DNA helicase
TOLA_RS08200	COG1196	nuclear chromosome segregation
TOLA_RS08225	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TOLA_RS08230	COG0830	nickel cation binding
TOLA_RS08240	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
TOLA_RS08245	COG0804	urea catabolic process
TOLA_RS08250	COG0832	Belongs to the urease beta subunit family
TOLA_RS08255	COG0831	urea catabolic process
TOLA_RS08260	COG0829	nickel cation binding
TOLA_RS08270	COG0411	ABC transporter
TOLA_RS08280	COG0559	Belongs to the binding-protein-dependent transport system permease family
TOLA_RS08290	COG5002	protein histidine kinase activity
TOLA_RS08290	COG0784	Response regulator, receiver
TOLA_RS08290	COG2198	Histidine kinase
TOLA_RS08295	COG0745	RESPONSE REGULATOR receiver
TOLA_RS08300	COG1522	sequence-specific DNA binding
TOLA_RS08310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TOLA_RS08335	COG0589	response to stress
TOLA_RS08355	COG0435	Glutathione S-transferase
TOLA_RS08380	COG1942	4-Oxalocrotonate Tautomerase
TOLA_RS08390	COG2272	Belongs to the type-B carboxylesterase lipase family
TOLA_RS08405	COG1349	DNA-binding transcription factor activity
TOLA_RS08415	COG1522	sequence-specific DNA binding
TOLA_RS08420	COG1280	lysine exporter protein (LysE YggA)
TOLA_RS08430	COG0157	Belongs to the NadC ModD family
TOLA_RS08450	COG1342	Belongs to the UPF0251 family
TOLA_RS08455	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TOLA_RS08470	COG1492	cobalamin metabolic process
TOLA_RS08535	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TOLA_RS08605	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TOLA_RS08610	COG4869	propanediol catabolic process
TOLA_RS08620	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
TOLA_RS08640	COG4656	Part of a membrane complex involved in electron transport
TOLA_RS08660	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TOLA_RS08665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TOLA_RS08665	COG1648	precorrin-2 dehydrogenase activity
TOLA_RS08680	COG3940	Belongs to the glycosyl hydrolase 43 family
TOLA_RS08685	COG1609	Transcriptional regulator
TOLA_RS08695	COG0395	ABC-type sugar transport system, permease component
TOLA_RS08700	COG1175	transmembrane transport
TOLA_RS08705	COG3842	ATPase activity
TOLA_RS08715	COG1472	Belongs to the glycosyl hydrolase 3 family
TOLA_RS08730	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TOLA_RS08735	COG0714	Associated with various cellular activities
TOLA_RS08765	COG0776	regulation of translation
TOLA_RS08770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TOLA_RS08770	COG0072	phenylalanine-tRNA ligase activity
TOLA_RS08775	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TOLA_RS08780	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TOLA_RS08785	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TOLA_RS08795	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TOLA_RS08800	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TOLA_RS08805	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TOLA_RS08820	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TOLA_RS08825	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TOLA_RS08830	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TOLA_RS08835	COG0131	Imidazoleglycerol-phosphate dehydratase
TOLA_RS08835	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TOLA_RS08840	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TOLA_RS08845	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TOLA_RS08850	COG0107	imidazoleglycerol-phosphate synthase activity
TOLA_RS08865	COG1846	Transcriptional regulator
TOLA_RS08875	COG1566	PFAM secretion protein HlyD family protein
TOLA_RS08880	COG2814	Major facilitator Superfamily
TOLA_RS08895	COG0039	L-malate dehydrogenase activity
TOLA_RS08920	COG0314	molybdopterin synthase activity
TOLA_RS08925	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
TOLA_RS08930	COG0315	cyclic pyranopterin monophosphate synthase activity
TOLA_RS08935	COG0521	Mo-molybdopterin cofactor biosynthetic process
TOLA_RS08940	COG0746	molybdenum cofactor guanylyltransferase activity
TOLA_RS08945	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TOLA_RS08965	COG2146	nitrite reductase [NAD(P)H] activity
TOLA_RS08965	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TOLA_RS08975	COG2223	nitrite transmembrane transporter activity
TOLA_RS08980	COG0583	DNA-binding transcription factor activity
TOLA_RS08990	COG0446	pyridine nucleotide-disulphide oxidoreductase
TOLA_RS08990	COG1902	pentaerythritol trinitrate reductase activity
TOLA_RS08995	COG1116	anion transmembrane transporter activity
TOLA_RS09000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TOLA_RS09005	COG1116	anion transmembrane transporter activity
TOLA_RS09005	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TOLA_RS09015	COG1648	precorrin-2 dehydrogenase activity
TOLA_RS09015	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TOLA_RS09020	COG0243	molybdopterin cofactor binding
TOLA_RS09025	COG1573	uracil-dna glycosylase
TOLA_RS09040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TOLA_RS09045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TOLA_RS09055	COG2814	Major facilitator Superfamily
TOLA_RS09065	COG1349	DNA-binding transcription factor activity
TOLA_RS09075	COG0667	Aldo Keto reductase
TOLA_RS09085	COG0583	DNA-binding transcription factor activity
TOLA_RS09090	COG1979	alcohol dehydrogenase
TOLA_RS09100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TOLA_RS09110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TOLA_RS09115	COG0129	dihydroxy-acid dehydratase activity
TOLA_RS09120	COG0800	Aldolase
TOLA_RS09135	COG1609	Transcriptional regulator
TOLA_RS09170	COG3180	Ammonia monooxygenase
TOLA_RS09175	COG0443	Heat shock 70 kDa protein
TOLA_RS09185	COG1028	Short-chain dehydrogenase reductase Sdr
TOLA_RS09220	COG0778	Nitroreductase
TOLA_RS09230	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
TOLA_RS09235	COG2944	sequence-specific DNA binding
TOLA_RS09240	COG1238	metal cluster binding
TOLA_RS09270	COG2226	methyltransferase
TOLA_RS09285	COG1869	D-ribose catabolic process
TOLA_RS09295	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TOLA_RS09300	COG3958	Transketolase
TOLA_RS09305	COG3959	Transketolase, thiamine diphosphate binding domain
TOLA_RS09310	COG1172	Belongs to the binding-protein-dependent transport system permease family
TOLA_RS09315	COG1129	ABC transporter
TOLA_RS09325	COG1879	ABC-type sugar transport system periplasmic component
TOLA_RS09330	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TOLA_RS09340	COG3604	Transcriptional regulator
TOLA_RS09345	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
TOLA_RS09360	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TOLA_RS09370	COG0583	DNA-binding transcription factor activity
TOLA_RS09375	COG0439	Biotin carboxylase
TOLA_RS09380	COG5016	pyruvate
TOLA_RS09380	COG0511	ligase activity, forming carbon-carbon bonds
TOLA_RS09385	COG2194	sulfuric ester hydrolase activity
TOLA_RS09405	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TOLA_RS09425	COG1914	H( )-stimulated, divalent metal cation uptake system
TOLA_RS09430	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TOLA_RS09435	COG1984	allophanate hydrolase subunit 2
TOLA_RS09440	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TOLA_RS09455	COG1126	abc transporter atp-binding protein
TOLA_RS09490	COG3550	peptidyl-serine autophosphorylation
TOLA_RS09500	COG1349	DNA-binding transcription factor activity
TOLA_RS09510	COG1028	Short-chain dehydrogenase reductase Sdr
TOLA_RS09525	COG3730	PTS system glucitol sorbitol-specific
TOLA_RS09550	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TOLA_RS09590	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TOLA_RS09590	COG0517	IMP dehydrogenase activity
TOLA_RS09595	COG0673	inositol 2-dehydrogenase activity
TOLA_RS09600	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TOLA_RS09605	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
TOLA_RS09610	COG0574	Belongs to the PEP-utilizing enzyme family
TOLA_RS09610	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TOLA_RS09615	COG0371	Dehydrogenase
TOLA_RS09620	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TOLA_RS09630	COG2207	Transcriptional regulator
TOLA_RS09635	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TOLA_RS09640	COG2207	Transcriptional regulator
TOLA_RS09645	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TOLA_RS09650	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TOLA_RS09650	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TOLA_RS09650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TOLA_RS09660	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TOLA_RS09665	COG1882	Formate acetyltransferase
TOLA_RS09670	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TOLA_RS09675	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TOLA_RS09680	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TOLA_RS09690	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TOLA_RS09690	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TOLA_RS09690	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TOLA_RS09755	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TOLA_RS09760	COG0642	Histidine kinase
TOLA_RS09765	COG0745	RESPONSE REGULATOR receiver
TOLA_RS09770	COG0215	cysteine-tRNA ligase activity
TOLA_RS09775	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TOLA_RS09780	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TOLA_RS09795	COG2815	serine threonine protein kinase
TOLA_RS09795	COG0515	serine threonine protein kinase
TOLA_RS09820	COG1979	alcohol dehydrogenase
TOLA_RS09835	COG2207	Transcriptional regulator
TOLA_RS09850	COG3550	peptidyl-serine autophosphorylation
TOLA_RS09870	COG1737	Transcriptional regulator
TOLA_RS09875	COG1172	Belongs to the binding-protein-dependent transport system permease family
TOLA_RS09880	COG1129	ABC transporter
TOLA_RS09900	COG2211	Major facilitator Superfamily
TOLA_RS09915	COG1028	Short-chain dehydrogenase reductase Sdr
TOLA_RS09925	COG0318	PFAM AMP-dependent synthetase and ligase
TOLA_RS09935	COG3300	MHYT domain
TOLA_RS09935	COG5001	Diguanylate cyclase
TOLA_RS09945	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TOLA_RS09950	COG0730	response to heat
TOLA_RS09970	COG2186	Transcriptional regulator
TOLA_RS09975	COG3842	ATPase activity
TOLA_RS09985	COG1176	ABC-type spermidine putrescine transport system, permease component I
TOLA_RS09990	COG0573	inorganic phosphate transmembrane transporter activity
TOLA_RS10005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TOLA_RS10010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TOLA_RS10015	COG0805	protein transport
TOLA_RS10020	COG1940	carbohydrate kinase activity
TOLA_RS10025	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TOLA_RS10030	COG1172	Belongs to the binding-protein-dependent transport system permease family
TOLA_RS10035	COG1129	ABC transporter
TOLA_RS10040	COG1879	ABC-type sugar transport system periplasmic component
TOLA_RS10045	COG1737	Transcriptional regulator
TOLA_RS10050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TOLA_RS10050	COG1263	PTS System
TOLA_RS10050	COG2190	(PTS) system
TOLA_RS10060	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TOLA_RS10065	COG0698	ribose 5-phosphate isomerase
TOLA_RS10080	COG0765	amino acid transport
TOLA_RS10085	COG0765	amino acid transport
TOLA_RS10125	COG0667	Aldo Keto reductase
TOLA_RS10135	COG2814	Major facilitator Superfamily
TOLA_RS10145	COG0493	'glutamate synthase
TOLA_RS10150	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TOLA_RS10150	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TOLA_RS10150	COG1013	pyruvate-flavodoxin oxidoreductase activity
TOLA_RS10150	COG0674	pyruvate-flavodoxin oxidoreductase activity
TOLA_RS10175	COG0667	Aldo Keto reductase
TOLA_RS10180	COG1733	regulation of RNA biosynthetic process
TOLA_RS10185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TOLA_RS10190	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TOLA_RS10195	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TOLA_RS10205	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TOLA_RS10210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TOLA_RS10215	COG0583	DNA-binding transcription factor activity
TOLA_RS10225	COG2853	Lipoprotein
TOLA_RS10230	COG0105	UTP biosynthetic process
TOLA_RS10235	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TOLA_RS10245	COG0443	Heat shock 70 kDa protein
TOLA_RS10265	COG1104	cysteine desulfurase activity
TOLA_RS10270	COG1959	2 iron, 2 sulfur cluster binding
TOLA_RS10280	COG3154	lipid carrier protein
TOLA_RS10285	COG0826	peptidase U32
TOLA_RS10290	COG0826	peptidase U32
TOLA_RS10300	COG2897	thiosulfate sulfurtransferase activity
TOLA_RS10305	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TOLA_RS10310	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TOLA_RS10315	COG1862	Preprotein translocase
TOLA_RS10320	COG0343	queuine tRNA-ribosyltransferase activity
TOLA_RS10325	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TOLA_RS10335	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TOLA_RS10340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TOLA_RS10365	COG1088	dTDP-glucose 4,6-dehydratase activity
TOLA_RS10400	COG3754	Rhamnan synthesis protein F
TOLA_RS10415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TOLA_RS10430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TOLA_RS10435	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
TOLA_RS10445	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
TOLA_RS10450	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TOLA_RS10465	COG0704	Plays a role in the regulation of phosphate uptake
TOLA_RS10470	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TOLA_RS10475	COG0581	inorganic phosphate transmembrane transporter activity
TOLA_RS10480	COG0573	inorganic phosphate transmembrane transporter activity
TOLA_RS10485	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TOLA_RS10495	COG0590	tRNA wobble adenosine to inosine editing
TOLA_RS10505	COG5002	protein histidine kinase activity
TOLA_RS10520	COG0420	3'-5' exonuclease activity
TOLA_RS10530	COG2974	May be involved in recombination
TOLA_RS10535	COG0826	peptidase U32
TOLA_RS10540	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TOLA_RS10550	COG0483	inositol monophosphate 1-phosphatase activity
TOLA_RS10555	COG3135	benzoate transporter
TOLA_RS10560	COG1396	sequence-specific DNA binding
TOLA_RS10565	COG3300	MHYT domain
TOLA_RS10565	COG5001	Diguanylate cyclase
TOLA_RS10570	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TOLA_RS10575	COG2814	Major facilitator Superfamily
TOLA_RS10580	COG0109	protoheme IX farnesyltransferase activity
TOLA_RS10585	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
TOLA_RS10590	COG1845	cytochrome c oxidase, subunit III
TOLA_RS10595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TOLA_RS10600	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TOLA_RS10610	COG1253	flavin adenine dinucleotide binding
TOLA_RS10625	COG2119	membrane
TOLA_RS10635	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TOLA_RS10635	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TOLA_RS10635	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TOLA_RS10645	COG1355	regulation of microtubule-based process
TOLA_RS10650	COG3885	ferrous iron binding
TOLA_RS10650	COG2078	PFAM AMMECR1 domain protein
TOLA_RS10655	COG0825	malonyl-CoA metabolic process
TOLA_RS10670	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TOLA_RS10675	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TOLA_RS10680	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TOLA_RS10685	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TOLA_RS10700	COG0750	zinc metalloprotease
TOLA_RS10705	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TOLA_RS10710	COG0575	Belongs to the CDS family
TOLA_RS10715	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TOLA_RS10720	COG0233	cytoplasmic translational termination
TOLA_RS10725	COG0528	UMP kinase activity
TOLA_RS10730	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TOLA_RS10735	COG0052	Belongs to the universal ribosomal protein uS2 family
TOLA_RS10745	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
TOLA_RS10750	COG2171	N-acyltransferase activity
TOLA_RS10765	COG0747	negative chemotaxis
TOLA_RS10770	COG0601	transmembrane transport
TOLA_RS10775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TOLA_RS10780	COG4172	Belongs to the ABC transporter superfamily
TOLA_RS10785	COG0667	Aldo Keto reductase
TOLA_RS10790	COG2169	Transcriptional regulator
TOLA_RS10795	COG1486	melibiose metabolic process
TOLA_RS10815	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
TOLA_RS10820	COG1058	Belongs to the CinA family
TOLA_RS10820	COG1546	Belongs to the CinA family
TOLA_RS10835	COG0545	Peptidyl-prolyl cis-trans isomerase
TOLA_RS10840	COG2900	Belongs to the SlyX family
TOLA_RS10845	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TOLA_RS10850	COG1263	PTS System
TOLA_RS10850	COG2190	(PTS) system
TOLA_RS10850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TOLA_RS10855	COG0363	glucosamine-6-phosphate deaminase activity
TOLA_RS10860	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TOLA_RS10865	COG1940	carbohydrate kinase activity
TOLA_RS10865	COG1846	Transcriptional regulator
TOLA_RS10875	COG0583	DNA-binding transcription factor activity
TOLA_RS10880	COG1609	Transcriptional regulator
TOLA_RS10885	COG1621	beta-fructofuranosidase activity
TOLA_RS10890	COG0622	Phosphoesterase
TOLA_RS10900	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TOLA_RS10910	COG0417	DNA replication proofreading
TOLA_RS10920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TOLA_RS10925	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TOLA_RS10925	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TOLA_RS10930	COG0527	aspartate kinase activity
TOLA_RS10940	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
TOLA_RS10955	COG1172	Belongs to the binding-protein-dependent transport system permease family
TOLA_RS10960	COG1129	ABC transporter
TOLA_RS10965	COG1879	ABC-type sugar transport system periplasmic component
TOLA_RS10970	COG1069	ribulokinase activity
TOLA_RS10980	COG2160	L-arabinose isomerase activity
TOLA_RS10985	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TOLA_RS10995	COG0569	domain protein
TOLA_RS10995	COG2985	domain, Protein
TOLA_RS11005	COG3313	Fe-S protein
TOLA_RS11015	COG2814	Major facilitator Superfamily
TOLA_RS11025	COG0519	Catalyzes the synthesis of GMP from XMP
TOLA_RS11025	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TOLA_RS11030	COG0517	IMP dehydrogenase activity
TOLA_RS11030	COG0516	GMP reductase activity
TOLA_RS11035	COG1570	exodeoxyribonuclease VII activity
TOLA_RS11040	COG1607	acyl-coa hydrolase
TOLA_RS11045	COG2095	MarC family integral membrane protein
TOLA_RS11050	COG1454	alcohol dehydrogenase
TOLA_RS11050	COG1012	belongs to the aldehyde dehydrogenase family
TOLA_RS11060	COG0861	Integral membrane protein TerC family
TOLA_RS11065	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TOLA_RS11070	COG2890	protein-(glutamine-N5) methyltransferase activity
TOLA_RS11075	COG2840	Smr protein MutS2
TOLA_RS11085	COG2062	phosphohistidine phosphatase, SixA
TOLA_RS11095	COG0084	hydrolase, TatD family'
TOLA_RS11105	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TOLA_RS11110	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TOLA_RS11120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TOLA_RS11125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TOLA_RS11130	COG1028	Short-chain dehydrogenase reductase Sdr
TOLA_RS11145	COG0416	fatty acid biosynthetic process
TOLA_RS11150	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TOLA_RS11155	COG1399	metal-binding, possibly nucleic acid-binding protein
TOLA_RS11160	COG0424	maF-like protein
TOLA_RS11165	COG0546	phosphoglycolate phosphatase activity
TOLA_RS11170	COG0564	pseudouridine synthase activity
TOLA_RS11175	COG1530	ribonuclease E activity
TOLA_RS11180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TOLA_RS11185	COG0589	response to stress
TOLA_RS11190	COG0037	tRNA processing
TOLA_RS11205	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
TOLA_RS11210	COG0367	asparagine synthase
TOLA_RS11215	COG1380	Effector of murein hydrolase LrgA
TOLA_RS11220	COG1346	cytolysis
TOLA_RS11230	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TOLA_RS11235	COG0563	adenylate kinase activity
TOLA_RS11240	COG0326	Molecular chaperone. Has ATPase activity
TOLA_RS11245	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TOLA_RS11250	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TOLA_RS11255	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TOLA_RS11260	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TOLA_RS11270	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
TOLA_RS11290	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TOLA_RS11305	COG0045	succinate-CoA ligase (ADP-forming) activity
TOLA_RS11310	COG0508	dehydrogenase complex catalyzes the overall conversion of
TOLA_RS11315	COG0567	Dehydrogenase, E1 component
TOLA_RS11320	COG0372	Belongs to the citrate synthase family
TOLA_RS11325	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
TOLA_RS11330	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TOLA_RS11335	COG2835	tetraacyldisaccharide 4'-kinase activity
TOLA_RS11340	COG1663	tetraacyldisaccharide 4'-kinase activity
TOLA_RS11350	COG2333	competence protein COMEC
TOLA_RS11350	COG0658	competence protein
TOLA_RS11355	COG0586	Pfam SNARE associated Golgi protein
TOLA_RS11360	COG4591	ABC-type transport system involved in lipoprotein release permease component
TOLA_RS11365	COG1136	(ABC) transporter
TOLA_RS11370	COG4591	ABC-type transport system involved in lipoprotein release permease component
TOLA_RS11375	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TOLA_RS11380	COG1185	polyribonucleotide nucleotidyltransferase activity
TOLA_RS11385	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TOLA_RS11390	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TOLA_RS11395	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TOLA_RS11400	COG3064	Membrane
TOLA_RS11400	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TOLA_RS11405	COG0195	Participates in both transcription termination and antitermination
TOLA_RS11410	COG0779	Required for maturation of 30S ribosomal subunits
TOLA_RS11425	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TOLA_RS11430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TOLA_RS11435	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TOLA_RS11440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TOLA_RS11445	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TOLA_RS11450	COG1534	Rna-binding protein
TOLA_RS11455	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TOLA_RS11460	COG0484	heat shock protein binding
TOLA_RS11465	COG0443	Heat shock 70 kDa protein
TOLA_RS11470	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TOLA_RS11475	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TOLA_RS11480	COG0497	DNA recombination
TOLA_RS11485	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TOLA_RS11490	COG2914	Belongs to the UPF0125 (RnfH) family
TOLA_RS11495	COG2867	negative regulation of translational initiation
TOLA_RS11500	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TOLA_RS11505	COG0582	viral genome integration into host DNA
TOLA_RS11545	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TOLA_RS11560	COG4983	Phage plasmid primase, P4 family domain protein
TOLA_RS11575	COG5377	YqaJ viral recombinase family
TOLA_RS11640	COG0590	tRNA wobble adenosine to inosine editing
TOLA_RS11650	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TOLA_RS11655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TOLA_RS11680	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TOLA_RS11685	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TOLA_RS11690	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TOLA_RS11695	COG0193	aminoacyl-tRNA hydrolase activity
TOLA_RS11700	COG0012	GTP binding
TOLA_RS11705	COG1882	Formate acetyltransferase
TOLA_RS11710	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TOLA_RS11715	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TOLA_RS11745	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TOLA_RS11750	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TOLA_RS11755	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TOLA_RS11760	COG0531	amino acid
TOLA_RS11760	COG1674	ftsk spoiiie
TOLA_RS11770	COG0686	Belongs to the AlaDH PNT family
TOLA_RS11775	COG0492	ferredoxin-NADP+ reductase activity
TOLA_RS11780	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
TOLA_RS11785	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
TOLA_RS11790	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TOLA_RS11795	COG0542	response to heat
TOLA_RS11805	COG1278	Cold shock
TOLA_RS11810	COG0538	isocitrate dehydrogenase activity
TOLA_RS11820	COG0482	sulfurtransferase activity
TOLA_RS11825	COG2915	High frequency lysogenization protein hflD homolog
TOLA_RS11830	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TOLA_RS11840	COG2205	protein histidine kinase activity
TOLA_RS11845	COG4657	Part of a membrane complex involved in electron transport
TOLA_RS11850	COG2878	Part of a membrane complex involved in electron transport
TOLA_RS11855	COG4656	Part of a membrane complex involved in electron transport
TOLA_RS11865	COG4659	FMN binding
TOLA_RS11890	COG0531	amino acid
TOLA_RS11895	COG1408	metallophosphoesterase
TOLA_RS11930	COG0798	PFAM Bile acid sodium symporter
TOLA_RS11935	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TOLA_RS11940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TOLA_RS11955	COG0175	sulfate reduction
TOLA_RS11960	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TOLA_RS11965	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
TOLA_RS11975	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TOLA_RS11985	COG5001	Diguanylate cyclase
TOLA_RS12010	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TOLA_RS12015	COG0564	pseudouridine synthase activity
TOLA_RS12020	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
TOLA_RS12025	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TOLA_RS12035	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
TOLA_RS12040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TOLA_RS12045	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TOLA_RS12050	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TOLA_RS12055	COG2967	ApaG domain
TOLA_RS12060	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TOLA_RS12070	COG3610	response to peptide
TOLA_RS12075	COG2966	Psort location CytoplasmicMembrane, score
TOLA_RS12080	COG1289	transmembrane transporter activity
TOLA_RS12085	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TOLA_RS12090	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TOLA_RS12095	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TOLA_RS12100	COG0142	geranyltranstransferase activity
TOLA_RS12105	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TOLA_RS12110	COG0330	HflC and HflK could
TOLA_RS12115	COG0330	HflC and HflK could
TOLA_RS12120	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TOLA_RS12125	COG1923	regulation of RNA biosynthetic process
TOLA_RS12130	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TOLA_RS12135	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TOLA_RS12145	COG0802	atpase or kinase
TOLA_RS12150	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TOLA_RS12150	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TOLA_RS12165	COG0330	HflC and HflK could
TOLA_RS12190	COG1192	Involved in chromosome partitioning
TOLA_RS12230	COG0629	single-stranded DNA binding
TOLA_RS12235	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TOLA_RS12445	COG2003	Belongs to the UPF0758 family
TOLA_RS12495	COG1028	Short-chain dehydrogenase reductase Sdr
TOLA_RS12505	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TOLA_RS12510	COG2235	arginine
TOLA_RS12515	COG1288	antiporter activity
TOLA_RS12540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TOLA_RS12545	COG0842	Transport permease protein
TOLA_RS12545	COG1129	ABC transporter
TOLA_RS12550	COG0842	Transport permease protein
TOLA_RS12560	COG1028	Short-chain dehydrogenase reductase Sdr
TOLA_RS12580	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TOLA_RS12585	COG0786	glutamate:sodium symporter activity
TOLA_RS12590	COG3243	poly(R)-hydroxyalkanoic acid synthase
TOLA_RS12595	COG0589	response to stress
TOLA_RS12615	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TOLA_RS12620	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
TOLA_RS12625	COG0583	DNA-binding transcription factor activity
TOLA_RS12630	COG1396	sequence-specific DNA binding
TOLA_RS12640	COG0582	viral genome integration into host DNA
TOLA_RS12665	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
TOLA_RS12670	COG1162	GTPase activity
TOLA_RS12675	COG0688	phosphatidylethanolamine metabolic process
TOLA_RS12680	COG1053	succinate dehydrogenase
TOLA_RS12685	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TOLA_RS12690	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
TOLA_RS12695	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
TOLA_RS12700	COG0516	GMP reductase activity
TOLA_RS12710	COG0602	queuosine metabolic process
TOLA_RS12715	COG0359	binds to the 23S rRNA
TOLA_RS12720	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TOLA_RS12725	COG0360	Binds together with S18 to 16S ribosomal RNA
TOLA_RS12730	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TOLA_RS12735	COG1482	cell wall glycoprotein biosynthetic process
TOLA_RS12740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TOLA_RS12740	COG0301	tRNA thio-modification
TOLA_RS12745	COG1722	exodeoxyribonuclease VII activity
TOLA_RS12750	COG0142	geranyltranstransferase activity
TOLA_RS12755	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TOLA_RS12770	COG0679	Auxin Efflux Carrier
TOLA_RS12780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TOLA_RS12785	COG0601	transmembrane transport
TOLA_RS12825	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TOLA_RS12830	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TOLA_RS12835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TOLA_RS12840	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TOLA_RS12855	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TOLA_RS12855	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TOLA_RS12860	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TOLA_RS12865	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TOLA_RS12870	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TOLA_RS12875	COG0511	ligase activity, forming carbon-carbon bonds
TOLA_RS12880	COG0439	Biotin carboxylase
TOLA_RS12890	COG2264	protein methyltransferase activity
TOLA_RS12900	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
TOLA_RS12905	COG2194	sulfuric ester hydrolase activity
TOLA_RS12910	COG1119	ATPase activity
TOLA_RS12925	COG0163	prenyltransferase activity
TOLA_RS12930	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TOLA_RS12935	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TOLA_RS12940	COG0529	Catalyzes the synthesis of activated sulfate
TOLA_RS12945	COG2895	sulfate adenylyltransferase (ATP) activity
TOLA_RS12950	COG0175	sulfate reduction
TOLA_RS12955	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TOLA_RS12955	COG1648	precorrin-2 dehydrogenase activity
TOLA_RS12960	COG0330	HflC and HflK could
TOLA_RS12965	COG1585	Membrane protein implicated in regulation of membrane protease activity
TOLA_RS12970	COG0039	L-malate dehydrogenase activity
TOLA_RS12975	COG1438	arginine binding
TOLA_RS12980	COG3290	protein histidine kinase activity
TOLA_RS12985	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
TOLA_RS12985	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
TOLA_RS13005	COG4565	transcriptional regulatory protein
TOLA_RS13010	COG3842	ATPase activity
TOLA_RS13020	COG1840	ABC-type Fe3 transport system, periplasmic component
TOLA_RS13025	COG0347	Belongs to the P(II) protein family
TOLA_RS13030	COG3112	Uncharacterised protein family (UPF0231)
TOLA_RS13035	COG1049	propionate catabolic process, 2-methylcitrate cycle
TOLA_RS13040	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TOLA_RS13050	COG0446	pyridine nucleotide-disulphide oxidoreductase
TOLA_RS13080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TOLA_RS13085	COG2084	Dehydrogenase
TOLA_RS13090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TOLA_RS13095	COG0508	dehydrogenase complex catalyzes the overall conversion of
TOLA_RS13100	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
TOLA_RS13110	COG3835	regulator
TOLA_RS13115	COG1929	Belongs to the glycerate kinase type-1 family
TOLA_RS13120	COG2084	Dehydrogenase
TOLA_RS13125	COG3836	Belongs to the HpcH HpaI aldolase family
TOLA_RS13130	COG4948	Mandelate Racemase Muconate Lactonizing
TOLA_RS13135	COG4948	Mandelate Racemase Muconate Lactonizing
TOLA_RS13140	COG2271	Major facilitator Superfamily
TOLA_RS13145	COG2721	sulfolactate sulfo-lyase activity
TOLA_RS13150	COG3023	N-Acetylmuramoyl-L-alanine amidase
TOLA_RS13160	COG0561	phosphatase activity
TOLA_RS13165	COG1115	amino acid carrier protein
TOLA_RS13170	COG0776	regulation of translation
TOLA_RS13185	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TOLA_RS13190	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
TOLA_RS13195	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TOLA_RS13200	COG0560	Phosphoserine phosphatase
TOLA_RS13205	COG0813	purine-nucleoside phosphorylase activity
TOLA_RS13210	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TOLA_RS13215	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
TOLA_RS13220	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TOLA_RS13225	COG0084	hydrolase, TatD family'
TOLA_RS13245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TOLA_RS13250	COG0557	exoribonuclease II activity
TOLA_RS13275	COG0180	Tryptophanyl-tRNA synthetase
TOLA_RS13280	COG0546	phosphoglycolate phosphatase activity
TOLA_RS13285	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TOLA_RS13290	COG0338	D12 class N6 adenine-specific DNA methyltransferase
TOLA_RS13300	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TOLA_RS13305	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TOLA_RS13310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TOLA_RS13315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TOLA_RS13330	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TOLA_RS13360	COG2813	Specifically methylates the guanine in position
TOLA_RS13365	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TOLA_RS13370	COG0297	glycogen (starch) synthase activity
TOLA_RS13395	COG2017	converts alpha-aldose to the beta-anomer
TOLA_RS13400	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TOLA_RS13405	COG1085	galactose-1-phosphate uridylyltransferase
TOLA_RS13410	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TOLA_RS13415	COG1609	Transcriptional regulator
TOLA_RS13425	COG1129	ABC transporter
TOLA_RS13435	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TOLA_RS13440	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TOLA_RS13445	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TOLA_RS13445	COG0649	NAD binding
TOLA_RS13450	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TOLA_RS13455	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TOLA_RS13460	COG1034	ATP synthesis coupled electron transport
TOLA_RS13465	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TOLA_RS13470	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TOLA_RS13475	COG0839	Belongs to the complex I subunit 6 family
TOLA_RS13480	COG0713	ATP synthesis coupled electron transport
TOLA_RS13485	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TOLA_RS13490	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TOLA_RS13495	COG1007	ATP synthesis coupled electron transport
TOLA_RS13500	COG2188	Transcriptional regulator
TOLA_RS13505	COG1979	alcohol dehydrogenase
TOLA_RS13510	COG1486	melibiose metabolic process
TOLA_RS13515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TOLA_RS13515	COG1263	PTS System
TOLA_RS13520	COG0248	Ppx GppA phosphatase
TOLA_RS13525	COG0513	Belongs to the DEAD box helicase family
TOLA_RS13530	COG3118	belongs to the thioredoxin family
TOLA_RS13550	COG3267	Type II secretory pathway component ExeA
TOLA_RS13550	COG3409	Peptidoglycan-binding domain 1 protein
TOLA_RS13555	COG0617	tRNA 3'-terminal CCA addition
TOLA_RS13565	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TOLA_RS13570	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TOLA_RS13575	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TOLA_RS13580	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TOLA_RS13625	COG3561	AntA/AntB antirepressor
TOLA_RS13640	COG0582	viral genome integration into host DNA
TOLA_RS13645	COG4584	PFAM Integrase catalytic
TOLA_RS13650	COG1484	DNA-dependent DNA replication
TOLA_RS13675	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TOLA_RS13680	COG2027	D-alanyl-D-alanine carboxypeptidase
TOLA_RS13685	COG0436	Aminotransferase
TOLA_RS13690	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
TOLA_RS13695	COG0778	Nitroreductase
TOLA_RS13700	COG0616	signal peptide processing
TOLA_RS13705	COG0252	asparaginase activity
TOLA_RS13710	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TOLA_RS13720	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TOLA_RS13725	COG1640	4-alpha-glucanotransferase
TOLA_RS13730	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TOLA_RS13735	COG0676	glucose-6-phosphate 1-epimerase activity
TOLA_RS13740	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TOLA_RS13790	COG2885	chlorophyll binding
TOLA_RS13795	COG0823	Involved in the tonB-independent uptake of proteins
TOLA_RS13800	COG3064	Membrane
TOLA_RS13810	COG0811	peptide transport
TOLA_RS13815	COG0824	Thioesterase
TOLA_RS13825	COG1294	oxidase, subunit
TOLA_RS13835	COG2255	four-way junction helicase activity
TOLA_RS13840	COG0632	four-way junction helicase activity
TOLA_RS13845	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TOLA_RS13850	COG0217	transcriptional regulatory protein
TOLA_RS13855	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TOLA_RS13865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TOLA_RS13870	COG1702	phosphate starvation-inducible protein PhoH
TOLA_RS13875	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TOLA_RS13880	COG4535	Mg2 and Co2 transporter CorC
TOLA_RS13885	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TOLA_RS13890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TOLA_RS13900	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TOLA_RS13910	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TOLA_RS13945	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TOLA_RS13950	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TOLA_RS13955	COG2137	regulation of response to DNA damage stimulus
TOLA_RS13960	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TOLA_RS13965	COG1546	Belongs to the CinA family
TOLA_RS13970	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TOLA_RS13980	COG1388	LysM domain
TOLA_RS13980	COG4942	peptidase
TOLA_RS13985	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TOLA_RS13990	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TOLA_RS13995	COG0585	pseudouridine synthase activity
TOLA_RS14005	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TOLA_RS14010	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TOLA_RS14015	COG0148	phosphopyruvate hydratase activity
TOLA_RS14020	COG0504	CTP synthase activity
TOLA_RS14025	COG3956	TIGRFAM MazG family protein
TOLA_RS14030	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TOLA_RS14035	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TOLA_RS14055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TOLA_RS14060	COG3089	Belongs to the UPF0270 family
TOLA_RS14070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TOLA_RS14075	COG0512	Glutamine amidotransferase of anthranilate synthase
TOLA_RS14080	COG3012	SEC-C Motif Domain Protein
TOLA_RS14085	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TOLA_RS14095	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TOLA_RS14100	COG3074	FtsZ-dependent cytokinesis
TOLA_RS14110	COG1045	serine acetyltransferase
TOLA_RS14115	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TOLA_RS14120	COG1177	transmembrane transport
TOLA_RS14125	COG1176	ABC-type spermidine putrescine transport system, permease component I
TOLA_RS14130	COG3842	ATPase activity
TOLA_RS14135	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TOLA_RS14140	COG3045	CreA protein
TOLA_RS14180	COG0542	response to heat
TOLA_RS14185	COG1496	oxidoreductase activity
TOLA_RS14190	COG0564	pseudouridine synthase activity
TOLA_RS14195	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TOLA_RS14200	COG1803	Methylglyoxal synthase
TOLA_RS14210	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TOLA_RS14215	COG0049	tRNA binding
TOLA_RS14220	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TOLA_RS14235	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
TOLA_RS14240	COG0251	oxidation-reduction process
TOLA_RS14245	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TOLA_RS14250	COG0085	RNA polymerase activity
TOLA_RS14255	COG0222	ribosome binding
TOLA_RS14260	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TOLA_RS14265	COG0081	regulation of translation
TOLA_RS14270	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TOLA_RS14275	COG0250	Participates in transcription elongation, termination and antitermination
TOLA_RS14305	COG1072	(Pantothenic acid kinase))
TOLA_RS14320	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TOLA_RS14325	COG4137	Cytochrome C assembly protein
TOLA_RS14330	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
TOLA_RS14335	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TOLA_RS14340	COG0739	heme binding
TOLA_RS14355	COG0714	Associated with various cellular activities
TOLA_RS14360	COG2425	protein containing a von Willebrand factor type A (vWA) domain
TOLA_RS14370	COG0540	Belongs to the ATCase OTCase family
TOLA_RS14375	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
TOLA_RS14380	COG2814	Major facilitator Superfamily
TOLA_RS14385	COG4651	solute:proton antiporter activity
TOLA_RS14385	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TOLA_RS14390	COG3133	Outer membrane lipoprotein
TOLA_RS14400	COG1671	Belongs to the UPF0178 family
TOLA_RS14405	COG0826	peptidase U32
TOLA_RS14410	COG5002	protein histidine kinase activity
TOLA_RS14410	COG5001	Diguanylate cyclase
TOLA_RS14410	COG3447	MASE1 domain protein
TOLA_RS14420	COG0459	protein refolding
TOLA_RS14425	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TOLA_RS14435	COG1324	tolerance protein
TOLA_RS14450	COG0733	neurotransmitter:sodium symporter activity
TOLA_RS14460	COG1686	Belongs to the peptidase S11 family
TOLA_RS14470	COG0495	leucyl-tRNA aminoacylation
TOLA_RS14480	COG1466	dna polymerase III delta subunit
TOLA_RS14485	COG0799	negative regulation of ribosome biogenesis
TOLA_RS14490	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TOLA_RS14495	COG0768	penicillin binding
TOLA_RS14500	COG0772	Belongs to the SEDS family
TOLA_RS14505	COG2951	lytic endotransglycosylase activity
TOLA_RS14510	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TOLA_RS14520	COG1686	Belongs to the peptidase S11 family
TOLA_RS14525	COG2921	Belongs to the UPF0250 family
TOLA_RS14530	COG0321	lipoyl(octanoyl) transferase activity
TOLA_RS14535	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TOLA_RS14540	COG2949	membrane
TOLA_RS14550	COG3300	MHYT domain
TOLA_RS14550	COG5001	Diguanylate cyclase
TOLA_RS14610	COG2026	Addiction module toxin, RelE StbE family
TOLA_RS14630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TOLA_RS14715	COG3384	dioxygenase
TOLA_RS14735	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
TOLA_RS14740	COG0583	DNA-binding transcription factor activity
TOLA_RS14750	COG3647	Membrane
TOLA_RS14770	COG0246	Mannitol dehydrogenase
TOLA_RS14775	COG1312	Catalyzes the dehydration of D-mannonate
TOLA_RS14780	COG2271	Major facilitator Superfamily
TOLA_RS14790	COG2186	Transcriptional regulator
TOLA_RS14835	COG3250	beta-galactosidase activity
TOLA_RS14840	COG0583	DNA-binding transcription factor activity
TOLA_RS14850	COG0439	Biotin carboxylase
TOLA_RS14865	COG3842	ATPase activity
TOLA_RS14885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TOLA_RS14915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TOLA_RS14920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TOLA_RS14925	COG1115	amino acid carrier protein
TOLA_RS14935	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TOLA_RS14940	COG0735	belongs to the Fur family
TOLA_RS14945	COG1121	(ABC) transporter
TOLA_RS14955	COG0803	Belongs to the bacterial solute-binding protein 9 family
TOLA_RS14965	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
TOLA_RS14970	COG1854	S-ribosylhomocysteine lyase activity
TOLA_RS14985	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TOLA_RS14990	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TOLA_RS15000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TOLA_RS15005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TOLA_RS15010	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TOLA_RS15015	COG5007	Belongs to the BolA IbaG family
TOLA_RS15025	COG2854	intermembrane phospholipid transfer
TOLA_RS15030	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TOLA_RS15035	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TOLA_RS15040	COG1127	ABC transporter
TOLA_RS15045	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TOLA_RS15045	COG0517	IMP dehydrogenase activity
TOLA_RS15050	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
TOLA_RS15060	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
TOLA_RS15065	COG1137	ATPase activity
TOLA_RS15070	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TOLA_RS15080	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TOLA_RS15085	COG1660	Displays ATPase and GTPase activities
TOLA_RS15090	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TOLA_RS15095	COG0583	DNA-binding transcription factor activity
TOLA_RS15105	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TOLA_RS15140	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TOLA_RS15145	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TOLA_RS15150	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TOLA_RS15155	COG0196	riboflavin kinase activity
TOLA_RS15160	COG0728	peptidoglycan biosynthetic process
TOLA_RS15165	COG0268	Binds directly to 16S ribosomal RNA
TOLA_RS15170	COG0640	Transcriptional regulator
TOLA_RS15175	COG0583	DNA-binding transcription factor activity
TOLA_RS15180	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TOLA_RS15185	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
TOLA_RS15195	COG0494	nUDIX hydrolase
TOLA_RS15200	COG3066	DNA modification
TOLA_RS15210	COG0335	large ribosomal subunit rRNA binding
TOLA_RS15215	COG0336	Belongs to the RNA methyltransferase TrmD family
TOLA_RS15220	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TOLA_RS15225	COG0228	four-way junction DNA binding
TOLA_RS15260	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
TOLA_RS15265	COG3084	Protein conserved in bacteria
TOLA_RS15275	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TOLA_RS15285	COG2960	long-chain fatty acid transporting porin activity
TOLA_RS15290	COG0514	ATP-dependent DNA helicase (RecQ)
TOLA_RS15300	COG2962	Rard protein
TOLA_RS15310	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TOLA_RS15315	COG1447	Phosphotransferase system cellobiose-specific component IIA
TOLA_RS15320	COG2723	6-phospho-beta-galactosidase activity
TOLA_RS15330	COG1609	Transcriptional regulator
TOLA_RS15335	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TOLA_RS15340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TOLA_RS15355	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TOLA_RS15365	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
TOLA_RS15370	COG1805	sodium ion transport
TOLA_RS15375	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
TOLA_RS15380	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
TOLA_RS15385	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
TOLA_RS15390	COG2871	sodium ion transport
TOLA_RS15400	COG0742	ribosomal rna small subunit methyltransferase
TOLA_RS15410	COG0006	proline dipeptidase activity
TOLA_RS15415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TOLA_RS15425	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TOLA_RS15435	COG1027	Aspartate ammonia-lyase
TOLA_RS15440	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TOLA_RS15450	COG0288	reversible hydration of carbon dioxide
TOLA_RS15460	COG2177	Part of the ABC transporter FtsEX involved in
TOLA_RS15465	COG2884	Cell division ATP-binding protein ftsE
TOLA_RS15470	COG0552	protein localization to endoplasmic reticulum
TOLA_RS15475	COG0742	ribosomal rna small subunit methyltransferase
TOLA_RS15485	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
TOLA_RS15505	COG1444	tRNA N-acetyltransferase activity
TOLA_RS15510	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TOLA_RS15515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TOLA_RS15525	COG2271	Major facilitator Superfamily
TOLA_RS15540	COG2721	sulfolactate sulfo-lyase activity
TOLA_RS15585	COG2856	Zn peptidase
TOLA_RS15600	COG0730	response to heat
TOLA_RS15615	COG0006	proline dipeptidase activity
TOLA_RS15630	COG2731	YhcH YjgK YiaL family protein
TOLA_RS15640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TOLA_RS15645	COG0800	Aldolase
TOLA_RS15650	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
TOLA_RS15655	COG1028	Short-chain dehydrogenase reductase Sdr
TOLA_RS15665	COG0204	Acyl-transferase
TOLA_RS15670	COG0714	Associated with various cellular activities
TOLA_RS15695	COG1785	Belongs to the alkaline phosphatase family
TOLA_RS15705	COG0606	chelatase, subunit chli
TOLA_RS15710	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TOLA_RS15725	COG3623	hexulose-6-phosphate isomerase
TOLA_RS15730	COG0561	phosphatase activity
TOLA_RS15745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TOLA_RS15755	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
TOLA_RS15760	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TOLA_RS15825	COG2390	Transcriptional regulator
TOLA_RS15830	COG0246	Mannitol dehydrogenase
TOLA_RS15835	COG1070	Carbohydrate kinase
TOLA_RS15845	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TOLA_RS15855	COG0189	ligase activity
TOLA_RS15855	COG4067	protein conserved in archaea
TOLA_RS15865	COG3978	acetolactate synthase activity
TOLA_RS15875	COG0129	dihydroxy-acid dehydratase activity
TOLA_RS15900	COG0583	DNA-binding transcription factor activity
TOLA_RS15905	COG0477	Major facilitator Superfamily
TOLA_RS15910	COG1609	Transcriptional regulator
TOLA_RS15915	COG2723	6-phospho-beta-galactosidase activity
TOLA_RS15920	COG1447	Phosphotransferase system cellobiose-specific component IIA
TOLA_RS15925	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TOLA_RS15930	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TOLA_RS15935	COG2723	6-phospho-beta-galactosidase activity
TOLA_RS15940	COG2190	(PTS) system
TOLA_RS15940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TOLA_RS15940	COG1263	PTS System
TOLA_RS15945	COG2272	Belongs to the type-B carboxylesterase lipase family
TOLA_RS15955	COG2193	ferroxidase activity
TOLA_RS15975	COG1061	Type III restriction enzyme res subunit
TOLA_RS15980	COG1396	sequence-specific DNA binding
TOLA_RS15985	COG3550	peptidyl-serine autophosphorylation
TOLA_RS15990	COG1797	cobyrinic acid a,c-diamide synthase activity
TOLA_RS15995	COG1492	cobalamin metabolic process
TOLA_RS16000	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TOLA_RS16015	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TOLA_RS16020	COG0019	diaminopimelate decarboxylase activity
TOLA_RS16025	COG1965	Belongs to the frataxin family
TOLA_RS16040	COG3072	Adenylate cyclase
TOLA_RS16045	COG0181	hydroxymethylbilane synthase activity
TOLA_RS16050	COG1587	Uroporphyrinogen-III synthase
TOLA_RS16055	COG2959	enzyme of heme biosynthesis
TOLA_RS16060	COG3071	HemY protein
TOLA_RS16065	COG0004	ammonium transporteR
TOLA_RS16070	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TOLA_RS16075	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TOLA_RS16080	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TOLA_RS16085	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TOLA_RS16090	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TOLA_RS16095	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TOLA_RS16105	COG0356	it plays a direct role in the translocation of protons across the membrane
TOLA_RS16115	COG1475	DNA binding
TOLA_RS16120	COG1192	Involved in chromosome partitioning
TOLA_RS16125	COG0357	Ribosomal RNA small subunit methyltransferase G
TOLA_RS16130	COG0445	tRNA wobble uridine modification
TOLA_RS16135	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
TOLA_RS16140	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TOLA_RS16155	COG0628	permease
TOLA_RS16160	COG0583	DNA-binding transcription factor activity
TOLA_RS16170	COG3530	Putative quorum-sensing-regulated virulence factor
TOLA_RS16180	COG1902	pentaerythritol trinitrate reductase activity
TOLA_RS16185	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TOLA_RS16190	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TOLA_RS16195	COG0698	ribose 5-phosphate isomerase
TOLA_RS16205	COG3395	kinase activity
TOLA_RS16215	COG0149	triose-phosphate isomerase activity
TOLA_RS16220	COG2390	Transcriptional regulator
TOLA_RS16235	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TOLA_RS16240	COG0706	membrane insertase activity
TOLA_RS16245	COG0594	ribonuclease P activity
TOLA_RS16250	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TOLA_RS16255	COG0318	PFAM AMP-dependent synthetase and ligase
TOLA_RS16255	COG0204	Acyl-transferase
TOLA_RS16280	COG2771	luxR family
TOLA_RS16305	COG3941	tape measure
TOLA_RS16315	COG1988	membrane-bound metal-dependent
TOLA_RS16390	COG0739	heme binding
TOLA_RS16395	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TOLA_RS16410	COG0724	RNA recognition motif