locus-tag class description HCG51_RS00005 ENOG41062D9 Histidine kinase HCG51_RS00015 ENOG4105BZU Histidine kinase HCG51_RS00040 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HCG51_RS00055 ENOG4108JJB ABC transporter HCG51_RS00060 ENOG4108V4M Cobalt abc transporter HCG51_RS00065 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HCG51_RS00070 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HCG51_RS00100 ENOG4105DHZ alpha beta HCG51_RS00115 ENOG4105CHM Aminotransferase HCG51_RS00140 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HCG51_RS00170 ENOG4105EMU Dehydrogenase HCG51_RS00175 ENOG4105CNF WD-40 repeat protein HCG51_RS00200 ENOG4105CA3 membrane-bound lytic murein transglycosylase HCG51_RS00240 ENOG4107E54 Small Multidrug Resistance protein HCG51_RS00260 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HCG51_RS00265 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HCG51_RS00270 ENOG4105M3Z response regulator HCG51_RS00295 ENOG4105F38 ABC transporter, permease HCG51_RS00300 ENOG4108HM4 ABC transporter HCG51_RS00315 ENOG4107RVG penicillin-binding protein HCG51_RS00320 ENOG4105CJN penicillin-binding protein HCG51_RS00325 ENOG4105CXB phosphoribosylaminoimidazole synthetase HCG51_RS00330 ENOG4105C0B DNA polymerase III (alpha subunit) HCG51_RS00395 ENOG4105CJ1 ABC, transporter HCG51_RS00420 ENOG4105ENT Efflux transporter rnd family, mfp subunit HCG51_RS00425 ENOG410834F Transcriptional regulator HCG51_RS00440 ENOG4105BZU Histidine kinase HCG51_RS00445 ENOG4105D38 putrescine abc transporter HCG51_RS00450 ENOG4105E2K Glycosyl transferase (Group 1 HCG51_RS00460 ENOG4105K6H D-cysteine desulfhydrase HCG51_RS00495 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) HCG51_RS00500 ENOG4105IBP Cyclic peptide transporter HCG51_RS00505 ENOG4105F32 YngK protein HCG51_RS00510 ENOG4107R8B 5'-nucleotidase HCG51_RS00540 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HCG51_RS00550 ENOG4105K6T rare lipoprotein A HCG51_RS00555 ENOG4105CSV Glutaminase HCG51_RS00580 ENOG4105CK5 oxidoreductase HCG51_RS00585 ENOG4108V1U phospholipid-binding protein HCG51_RS00595 ENOG4105C8Y Acetylornithine aminotransferase HCG51_RS00605 ENOG4105D9N nucleoside HCG51_RS00625 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) HCG51_RS00640 ENOG4108FN7 Aldo keto reductase HCG51_RS00685 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E HCG51_RS00750 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HCG51_RS00760 ENOG4105CMR udp-glucose 4-epimerase HCG51_RS00805 ENOG4108RCM Nitroreductase HCG51_RS00815 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HCG51_RS00835 ENOG4105BZU Histidine kinase HCG51_RS00850 ENOG4105C59 p-type ATPase HCG51_RS00885 ENOG4105E0X reductase HCG51_RS00930 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase HCG51_RS00935 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HCG51_RS00950 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HCG51_RS00955 ENOG41081F0 Precorrin-8x methylmutase HCG51_RS00960 ENOG4105DVK Precorrin-2 c20-methyltransferase HCG51_RS00965 ENOG4105VFU Rna-binding protein HCG51_RS00970 ENOG410848W 30S ribosomal protein S21 HCG51_RS00995 ENOG4105C08 Histidine kinase HCG51_RS01005 ENOG4105CQB FAD linked oxidase domain protein HCG51_RS01010 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HCG51_RS01025 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) HCG51_RS01050 ENOG4107T8Q Glycosyl transferase (Group 1 HCG51_RS01055 ENOG4106BQ7 Glycosyl Transferase HCG51_RS01070 ENOG4105EY8 ABC transporter HCG51_RS01090 ENOG41080UQ Transcriptional regulator HCG51_RS01170 ENOG4105BZU Histidine kinase HCG51_RS01180 ENOG4105D0S secretion protein (HlyD HCG51_RS01195 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HCG51_RS01205 ENOG4109015 Biopolymer transport protein exbD tolR HCG51_RS01325 ENOG4105BZU Histidine kinase HCG51_RS01330 ENOG4105WH1 Two component transcriptional regulator luxr family HCG51_RS01370 ENOG4105DGW oligopeptidase A HCG51_RS01380 ENOG4105MKU Transcriptional regulator HCG51_RS01385 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HCG51_RS01390 ENOG4105BZU Histidine kinase HCG51_RS01415 ENOG4105BZU Histidine kinase HCG51_RS01445 ENOG4107WDG serine threonine protein kinase HCG51_RS01455 ENOG4105CMQ Chloride channel HCG51_RS01460 ENOG4105GR3 Histidine kinase HCG51_RS01465 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HCG51_RS01520 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HCG51_RS01525 ENOG4107WCA isomerase HCG51_RS01550 ENOG4105D0M Protease HtpX homolog HCG51_RS01555 ENOG4105VN1 Heat shock protein HCG51_RS01600 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HCG51_RS01615 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HCG51_RS01620 ENOG4105BZM domain protein HCG51_RS01630 ENOG41086DT Membrane protein of unknown function HCG51_RS01650 ENOG4105TQG cytochrome C, class I HCG51_RS01660 ENOG4105WZW rhodanese family HCG51_RS01665 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HCG51_RS01685 ENOG4105CA3 membrane-bound lytic murein transglycosylase HCG51_RS01695 ENOG4105D0M Protease HtpX homolog HCG51_RS01700 ENOG4108V0P LemA family HCG51_RS01705 ENOG4108RCM Nitroreductase HCG51_RS01720 ENOG4105DX0 Hemolysin A HCG51_RS01730 ENOG4108TCG allophycocyanin beta subunit HCG51_RS01740 ENOG4105BZU Histidine kinase HCG51_RS01745 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HCG51_RS01755 ENOG4105D4Y metalloprotease HCG51_RS01770 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HCG51_RS01775 ENOG4105E2Z phosphate ABC transporter (Permease HCG51_RS01780 ENOG4105C8U phosphate abc transporter HCG51_RS01785 ENOG4105DJH phosphate HCG51_RS01790 ENOG41066UM arsR family transcriptional regulator HCG51_RS01825 ENOG4105WXN Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) HCG51_RS01830 ENOG410906A Beta-Ig-H3 fasciclin HCG51_RS01885 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HCG51_RS01915 ENOG4105KCK Peptidoglycan-associated lipoprotein HCG51_RS01920 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein HCG51_RS01925 ENOG4105F8J Adenylate Guanylate cyclase HCG51_RS01930 ENOG4107WDG serine threonine protein kinase HCG51_RS01990 ENOG4105CPQ Dehydrogenase HCG51_RS02020 ENOG4105F0K SARP family transcriptional regulator HCG51_RS02035 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase HCG51_RS02050 ENOG4108V06 Glutathione peroxidase HCG51_RS02060 ENOG4105CEP NADH dehydrogenase HCG51_RS02100 ENOG4105EHV domain protein HCG51_RS02105 ENOG4105BZU Histidine kinase HCG51_RS02120 ENOG4105C08 Histidine kinase HCG51_RS02210 ENOG4107QRP cobalamin biosynthesis protein CobW HCG51_RS02220 ENOG4105EWN Heme oxygenase HCG51_RS02225 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HCG51_RS02240 ENOG4107RGC Glycosyl transferase, family 2 HCG51_RS02245 ENOG4105CPK Glycosyl transferase (Group 1 HCG51_RS02250 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HCG51_RS02255 ENOG4105D3R alkyl hydroperoxide reductase HCG51_RS02265 ENOG410890F Dynamin family HCG51_RS02270 ENOG410890F Dynamin family HCG51_RS02300 ENOG4105BZU Histidine kinase HCG51_RS02305 ENOG4105BZU Histidine kinase HCG51_RS02325 ENOG4105FUA antagonist HCG51_RS02330 ENOG4107MMM Anti-sigma-factor antagonist HCG51_RS02350 ENOG4105KPY Small multidrug resistance protein HCG51_RS02355 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) HCG51_RS02360 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HCG51_RS02365 ENOG4105CJW magnesium transporter HCG51_RS02385 ENOG4107QN2 dihydrolipoyl dehydrogenase HCG51_RS02450 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) HCG51_RS02470 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HCG51_RS02475 ENOG4105D64 Mechanosensitive ion channel HCG51_RS02510 ENOG4108IJ8 ABC transporter HCG51_RS02555 ENOG4105XJC Two component transcriptional regulator (Winged helix family HCG51_RS02600 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HCG51_RS02655 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A HCG51_RS02690 ENOG4105EGD dinuclear metal center protein, YbgI family HCG51_RS02755 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HCG51_RS02760 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HCG51_RS02770 ENOG4105CEY Amp-dependent synthetase and ligase HCG51_RS02785 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related HCG51_RS02800 ENOG4105D64 Mechanosensitive ion channel HCG51_RS02955 ENOG4108IYU L-aspartate oxidase HCG51_RS02960 ENOG4105CPC Aldo Keto reductase HCG51_RS02965 ENOG4108PWY Carbohydrate-selective porin OprB HCG51_RS02970 ENOG4105GVF (ABC) transporter HCG51_RS03010 ENOG4108DBC nitroreductase HCG51_RS03015 ENOG4105E2Y ABC, transporter HCG51_RS03020 ENOG4105GVF (ABC) transporter HCG51_RS03030 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HCG51_RS03035 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HCG51_RS03040 ENOG4105FBW Monooxygenase HCG51_RS03045 ENOG4108UZX fmn reductase HCG51_RS03050 ENOG41062JF Transcriptional regulator HCG51_RS03055 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HCG51_RS03070 ENOG4105VF7 tolerance protein HCG51_RS03095 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HCG51_RS03120 ENOG4105C59 p-type ATPase HCG51_RS03130 ENOG4105E6M Sulphatase-modifying factor protein HCG51_RS03195 ENOG4105WD1 Membrane HCG51_RS03220 ENOG4105C0D helicase HCG51_RS03230 ENOG4108HMN Caspase domain HCG51_RS03300 ENOG4105GVF (ABC) transporter HCG51_RS03310 ENOG4108RXX maleylacetoacetate isomerase HCG51_RS03315 ENOG4105EPW hflc protein HCG51_RS03325 ENOG4107TSN permease HCG51_RS03340 ENOG4105CPF Cell wall formation (By similarity) HCG51_RS03355 ENOG4107B2H carbonic anhydrase HCG51_RS03365 ENOG4105CPC Aldo Keto reductase HCG51_RS03390 ENOG4105C0H protease HCG51_RS03410 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HCG51_RS03430 ENOG4105BZU Histidine kinase HCG51_RS03445 ENOG4105D0B Nitrogenase protein alpha chain HCG51_RS03450 ENOG4105CPC Aldo Keto reductase HCG51_RS03465 ENOG4108ZGC gaf domain protein HCG51_RS03485 ENOG4105D01 (LipO)protein HCG51_RS03505 ENOG4108SHQ Glutathione S-transferase HCG51_RS03515 ENOG4105C7N Xanthine uracil vitamin C permease HCG51_RS03520 ENOG4107T8P acyl-Coa dehydrogenase HCG51_RS03540 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HCG51_RS03560 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HCG51_RS03565 ENOG4105GVF (ABC) transporter HCG51_RS03575 ENOG4108K4B hydrolase HCG51_RS03595 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HCG51_RS03640 ENOG4108IQK o-acetylhomoserine HCG51_RS03650 ENOG4105D01 (LipO)protein HCG51_RS03655 ENOG4108UMI ABC transporter, permease HCG51_RS03660 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HCG51_RS03665 ENOG4105D01 (LipO)protein HCG51_RS03675 ENOG4105FBW Monooxygenase HCG51_RS03685 ENOG4107T8P acyl-Coa dehydrogenase HCG51_RS03695 ENOG4105EMU Dehydrogenase HCG51_RS03700 ENOG4105GVF (ABC) transporter HCG51_RS03720 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) HCG51_RS03725 ENOG4107QPB Beta-lactamase domain protein HCG51_RS03745 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HCG51_RS03750 ENOG4105GVF (ABC) transporter HCG51_RS03765 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HCG51_RS03775 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HCG51_RS03795 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HCG51_RS03820 ENOG4107XGZ Hydrolase HCG51_RS03845 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HCG51_RS03880 ENOG4107Y3V -acetyltransferase HCG51_RS03885 ENOG4105KHC sulfurtransferase HCG51_RS03915 ENOG4105E1J oxidoreductase HCG51_RS03925 ENOG4105CPC Aldo Keto reductase HCG51_RS03930 ENOG4105BZ1 (ABC) transporter HCG51_RS03940 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) HCG51_RS03945 ENOG4107MKT Stringent starvation protein a HCG51_RS03975 ENOG4105GVF (ABC) transporter HCG51_RS03980 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HCG51_RS03985 ENOG4105VF7 tolerance protein HCG51_RS03995 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HCG51_RS04005 ENOG4105C5I Dehydrogenase HCG51_RS04015 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HCG51_RS04030 ENOG4105GVF (ABC) transporter HCG51_RS04060 ENOG4105FBW Monooxygenase HCG51_RS04070 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HCG51_RS04100 ENOG4105E6M Sulphatase-modifying factor protein HCG51_RS04105 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) HCG51_RS04115 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 HCG51_RS04140 ENOG4105C8U phosphate abc transporter HCG51_RS04145 ENOG4105PWN phosphate abc transporter HCG51_RS04150 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HCG51_RS04175 ENOG4108PWY Carbohydrate-selective porin OprB HCG51_RS04180 ENOG4105D5T phosphonate abc transporter HCG51_RS04185 ENOG4105EHI Phosphonate ABC transporter, periplasmic HCG51_RS04200 ENOG4105FDP GntR family transcriptional regulator HCG51_RS04205 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HCG51_RS04225 ENOG4105FD8 phosphonate metabolism protein PhnM HCG51_RS04235 ENOG4105FT8 Phosphonate metabolism HCG51_RS04240 ENOG4105ENV phosphonate C-P lyase system protein PhnK HCG51_RS04245 ENOG4105HRV phosphonate c-p lyase system protein phnl HCG51_RS04250 ENOG4105FD8 phosphonate metabolism protein PhnM HCG51_RS04255 ENOG4105CEY Amp-dependent synthetase and ligase HCG51_RS04320 ENOG4105BZU Histidine kinase HCG51_RS04325 ENOG41090HT Inherit from COG: transposase HCG51_RS04345 ENOG4105BZU Histidine kinase HCG51_RS04360 ENOG4107RCI amp-dependent synthetase and ligase HCG51_RS04375 ENOG4107SQU synthase HCG51_RS04380 ENOG4107UJ9 cyclopropane-fatty-acyl-phospholipid synthase HCG51_RS04410 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) HCG51_RS04415 ENOG4107QN2 dihydrolipoyl dehydrogenase HCG51_RS04435 ENOG4107RSM transcriptional regulator HCG51_RS04465 ENOG4108HMN Caspase domain HCG51_RS04470 ENOG4105C7N Xanthine uracil vitamin C permease HCG51_RS04475 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HCG51_RS04500 ENOG4105BZU Histidine kinase HCG51_RS04510 ENOG4105VN1 Heat shock protein HCG51_RS04525 ENOG4108YZN class I peptide chain release factor HCG51_RS04540 ENOG4105BZU Histidine kinase HCG51_RS04545 ENOG4108TQ9 Histidine kinase HCG51_RS04555 ENOG4105WVZ Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HCG51_RS04580 ENOG4105D9P serine threonine protein kinase HCG51_RS04595 ENOG4108P5B Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins (By similarity) HCG51_RS04645 ENOG4105CC5 ABC transporter HCG51_RS04650 ENOG4105DIK (ABC) transporter HCG51_RS04655 ENOG4108XAN ABC transporter HCG51_RS04685 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HCG51_RS04695 ENOG4107P5I polyketide synthase HCG51_RS04700 ENOG4107QKG PfaD family HCG51_RS04705 ENOG4107SQU synthase HCG51_RS04715 ENOG4105C0W non-ribosomal peptide synthetase HCG51_RS04720 ENOG4108JA1 polyketide synthase HCG51_RS04755 ENOG4105FA0 parb-like partition protein HCG51_RS04765 ENOG4107X8C Efflux transporter RND family MFP subunit HCG51_RS04800 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase HCG51_RS04810 ENOG4108W6C Dehydrogenase HCG51_RS04820 ENOG4107U7Q Transfers the fatty acyl group on membrane lipoproteins (By similarity) HCG51_RS04840 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HCG51_RS04850 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family HCG51_RS04890 ENOG4107R4J Chloride channel HCG51_RS04900 ENOG4107R0W ABC transporter HCG51_RS04945 ENOG410841Q phosphoesterase PA-phosphatase related protein HCG51_RS04950 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HCG51_RS04965 ENOG4105CEP NADH dehydrogenase HCG51_RS04970 ENOG4107RFW hydrolase family 57 HCG51_RS04975 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HCG51_RS04990 ENOG4105CFG Acts as a chaperone (By similarity) HCG51_RS04995 ENOG4107Z9D Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HCG51_RS05000 ENOG4107QHF type ii secretion system protein e HCG51_RS05005 ENOG4105CZX twitching motility protein HCG51_RS05010 ENOG4105D7Q type ii secretion system HCG51_RS05040 ENOG410901P UPF0249 protein HCG51_RS05045 ENOG4105D9P serine threonine protein kinase HCG51_RS05100 ENOG4105F0K SARP family transcriptional regulator HCG51_RS05110 ENOG4105C12 Phosphoribosylglycinamide synthetase HCG51_RS05185 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) HCG51_RS05200 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HCG51_RS05245 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HCG51_RS05255 ENOG4105YVZ photosystem II HCG51_RS05310 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HCG51_RS05315 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HCG51_RS05345 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HCG51_RS05350 ENOG4105CAK Cell division ATP-binding protein ftsE HCG51_RS05360 ENOG4105WH1 Two component transcriptional regulator luxr family HCG51_RS05365 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HCG51_RS05405 ENOG4108KGH TRANSCRIPTIONal HCG51_RS05470 ENOG4105XEV csbD-like HCG51_RS05480 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HCG51_RS05535 ENOG4105X1Q TOBE domain protein HCG51_RS05550 ENOG4105V5Z Iron-sulfur cluster assembly accessory protein HCG51_RS05560 ENOG4105R88 May protect the nitrogenase Fe-Mo protein from oxidative damage (By similarity) HCG51_RS05565 ENOG4105X87 nitrogen fixation HCG51_RS05575 ENOG4108UR2 Nitrogen fixation protein NifX HCG51_RS05580 ENOG4105DK8 Nitrogenase molybdenum-iron cofactor biosynthesis protein NifN HCG51_RS05665 ENOG4105CY9 nitrogenase molybdenum-iron protein beta chain HCG51_RS05740 ENOG4105KVH Transcriptional regulator HCG51_RS05745 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HCG51_RS05750 ENOG4108S59 HCG51_RS05770 ENOG4105E1F short-chain dehydrogenase reductase HCG51_RS05800 ENOG4107RIU May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins (By similarity) HCG51_RS05815 ENOG4106NZI LysR family Transcriptional regulator HCG51_RS05840 ENOG41086BQ Protein CrcB homolog HCG51_RS05845 ENOG4105FFC UPF0187 protein HCG51_RS05850 ENOG4105FFC UPF0187 protein HCG51_RS05955 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HCG51_RS06030 ENOG4107S73 homocitrate synthase HCG51_RS06065 ENOG4107QP0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HCG51_RS06075 ENOG4107YCR Transcriptional regulator, ARSR family HCG51_RS06080 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HCG51_RS06085 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HCG51_RS06100 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HCG51_RS06110 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HCG51_RS06115 ENOG4105DFU Cell wall formation (By similarity) HCG51_RS06120 ENOG4105D4A Cell wall formation (By similarity) HCG51_RS06125 ENOG41082EZ Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HCG51_RS06135 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HCG51_RS06140 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HCG51_RS06155 ENOG4105BZU Histidine kinase HCG51_RS06175 ENOG4107U8J Export protein HCG51_RS06195 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HCG51_RS06200 ENOG4105BZU Histidine kinase HCG51_RS06350 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HCG51_RS06360 ENOG41061ZR Transcriptional regulator HCG51_RS06370 ENOG4105F8J Adenylate Guanylate cyclase HCG51_RS06385 ENOG4105BZU Histidine kinase HCG51_RS06390 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HCG51_RS06430 ENOG4108JQ9 ABC transporter HCG51_RS06540 ENOG4105F8J Adenylate Guanylate cyclase HCG51_RS06550 ENOG4107QPR SAICAR synthetase HCG51_RS06555 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HCG51_RS06560 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HCG51_RS06565 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HCG51_RS06595 ENOG4105VCC 30S ribosomal protein S21 HCG51_RS06605 ENOG41082B1 30S ribosomal protein S16 HCG51_RS06620 ENOG4107RAQ aminopeptidase HCG51_RS06630 ENOG4105BZU Histidine kinase HCG51_RS06635 ENOG4107TIF Phenazine biosynthesis protein, PhzF family HCG51_RS06660 ENOG4105C1V Peptidase, M16 HCG51_RS06710 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HCG51_RS06730 ENOG4108JJA ABC, transporter HCG51_RS06750 ENOG4105CJW magnesium transporter HCG51_RS06815 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HCG51_RS06820 ENOG4105D9P serine threonine protein kinase HCG51_RS06880 ENOG4108S64 thioredoxin-like protein txlA HCG51_RS06890 ENOG4105W5Q DNA repair protein (RadC HCG51_RS06895 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HCG51_RS06915 ENOG41066AK Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) (By similarity) HCG51_RS06920 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) HCG51_RS06940 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HCG51_RS06950 ENOG4105C1B dTDP-glucose 4-6-dehydratase HCG51_RS06960 ENOG4105BZF Glycosyl transferase (Group 1 HCG51_RS06965 ENOG4105D3Q Sugar transferase HCG51_RS06980 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HCG51_RS07000 ENOG4105BZ1 (ABC) transporter HCG51_RS07015 ENOG4105CPK Glycosyl transferase (Group 1 HCG51_RS07025 ENOG4105ECJ Glycosyl Transferase HCG51_RS07035 ENOG4105CHF Glutathione S-transferase HCG51_RS07075 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HCG51_RS07085 ENOG4105BZU Histidine kinase HCG51_RS07105 ENOG4105KAN Probably a ribosomal protein or a ribosome-associated protein (By similarity) HCG51_RS07140 ENOG4108JYK Dehydrogenase HCG51_RS07215 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HCG51_RS07225 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HCG51_RS07235 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HCG51_RS07240 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HCG51_RS07275 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase HCG51_RS07280 ENOG4105NTW Transcriptional regulator HCG51_RS07290 ENOG4105EUB pirin domain protein HCG51_RS07345 ENOG4105CVJ phosphoglycerate mutase HCG51_RS07410 ENOG4105NXP Functions as an electron carrier between membrane-bound cytochrome b6-f and photosystem I in oxygenic photosynthesis (By similarity) HCG51_RS07445 ENOG4105BZU Histidine kinase HCG51_RS07505 ENOG4107RAQ aminopeptidase HCG51_RS07520 ENOG4105DDQ anthranilate synthase HCG51_RS07545 ENOG4105EWU Squalene--hopene cyclase HCG51_RS07555 ENOG4105CND Glycosyl transferase, family 2 HCG51_RS07565 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HCG51_RS07570 ENOG41089UC methyltransferase, type 11 HCG51_RS07640 ENOG4108XNA Gas vesicle HCG51_RS07675 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HCG51_RS07690 ENOG4105ERG peptidase m48, ste24p HCG51_RS07695 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HCG51_RS07700 ENOG4105KHC sulfurtransferase HCG51_RS07705 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HCG51_RS07710 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HCG51_RS07715 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HCG51_RS07725 ENOG4105D44 asparaginase HCG51_RS07740 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HCG51_RS07770 ENOG4107U9K TROVE domain-containing protein HCG51_RS07780 ENOG4105BZU Histidine kinase HCG51_RS07815 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HCG51_RS07820 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) HCG51_RS07825 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HCG51_RS07835 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HCG51_RS07845 ENOG4105CIA precorrin-4 C(11)-methyltransferase HCG51_RS07915 ENOG4105C0X amino acid HCG51_RS07950 ENOG4105C26 Dehydrogenase HCG51_RS08030 ENOG4105C0D helicase HCG51_RS08035 ENOG4107XWB Zinc finger, swim domain protein HCG51_RS08100 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HCG51_RS08110 ENOG4105CQR helicase HCG51_RS08120 ENOG41080W8 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HCG51_RS08140 ENOG4107U45 Cobalt transport protein HCG51_RS08145 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HCG51_RS08160 ENOG4107QJE Chromosome Partitioning Protein HCG51_RS08180 ENOG41063FQ CsbD-like protein HCG51_RS08195 ENOG4105BZU Histidine kinase HCG51_RS08200 ENOG4107Z5C methylesterase HCG51_RS08210 ENOG4108UV1 cellular component movement HCG51_RS08225 ENOG4108UN4 phage SPO1 DNA polymerase-related protein HCG51_RS08240 ENOG4105BZU Histidine kinase HCG51_RS08275 ENOG4105D7N magnesium and cobalt transport protein CorA HCG51_RS08285 ENOG4105C0A alcohol dehydrogenase HCG51_RS08290 ENOG4105F1A Pyruvate formate-lyase HCG51_RS08295 ENOG4105C6N Formate acetyltransferase HCG51_RS08305 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HCG51_RS08350 ENOG4105K64 Glycosyl transferase, family 2 HCG51_RS08355 ENOG4105D5K Hemolysin activator protein HCG51_RS08365 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HCG51_RS08380 ENOG4105BZU Histidine kinase HCG51_RS08445 ENOG4105C7K acetolactate synthase HCG51_RS08450 ENOG4108ZAF Molybdopterin HCG51_RS08480 ENOG4105DZR Type I site-specific deoxyribonuclease HCG51_RS08525 ENOG4105MN3 Resolvase HCG51_RS08555 ENOG4108ZAF Molybdopterin HCG51_RS08590 ENOG4105ERG peptidase m48, ste24p HCG51_RS08600 ENOG4105CNW domain protein HCG51_RS08630 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) HCG51_RS08635 ENOG4105M03 Domain of unknown function (DUF955) HCG51_RS08665 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HCG51_RS08775 ENOG410645W Thiamin biosynthesis protein ThiH HCG51_RS08785 ENOG41089N3 Inherit from COG: cobyrinic Acid a,c-diamide synthase HCG51_RS08790 ENOG4108TQ9 Histidine kinase HCG51_RS08795 ENOG4108UXE Protein tyrosine phosphatase HCG51_RS08935 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HCG51_RS08955 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HCG51_RS08975 ENOG4108V0P LemA family HCG51_RS08980 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HCG51_RS09050 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HCG51_RS09060 ENOG4105FDP GntR family transcriptional regulator HCG51_RS09080 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HCG51_RS09090 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HCG51_RS09095 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HCG51_RS09110 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HCG51_RS09120 ENOG4106F1P AAA ATPase, central domain protein HCG51_RS09155 ENOG4105C26 Dehydrogenase HCG51_RS09185 ENOG4105CQM Urea amidohydrolase subunit alpha HCG51_RS09195 ENOG4105KI2 Urea amidohydrolase subunit beta HCG51_RS09200 ENOG4108YZ9 Urea amidohydrolase subunit gamma HCG51_RS09205 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HCG51_RS09230 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HCG51_RS09245 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase HCG51_RS09250 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HCG51_RS09260 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HCG51_RS09280 ENOG4105DKQ ROK family HCG51_RS09295 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HCG51_RS09315 ENOG4105E6M Sulphatase-modifying factor protein HCG51_RS09370 ENOG4105CDU Replicative dna helicase HCG51_RS09385 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HCG51_RS09405 ENOG4105BZ1 (ABC) transporter HCG51_RS09475 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HCG51_RS09485 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) HCG51_RS09515 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HCG51_RS09530 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HCG51_RS09540 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HCG51_RS09590 ENOG4105EA8 2-Nitropropane dioxygenase HCG51_RS09615 ENOG4105DXN mazG family HCG51_RS09620 ENOG4107R0W ABC transporter HCG51_RS09625 ENOG4105C26 Dehydrogenase HCG51_RS09655 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HCG51_RS09660 ENOG4105W8H transhydrogenase (subunit alpha HCG51_RS09665 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HCG51_RS09690 ENOG4107RIX inner membrane protein translocase component YidC HCG51_RS09705 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HCG51_RS09725 ENOG41063JG Transcriptional regulator HCG51_RS09755 ENOG4108UV1 cellular component movement HCG51_RS09765 ENOG4105CEY Amp-dependent synthetase and ligase HCG51_RS09795 ENOG4108JJA ABC, transporter HCG51_RS09815 ENOG4105CKI cobalamin synthesis protein HCG51_RS09830 ENOG4107QRT dEAD DEAH box helicase HCG51_RS09835 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HCG51_RS09840 ENOG4105E2Z phosphate ABC transporter (Permease HCG51_RS09845 ENOG4105C8U phosphate abc transporter HCG51_RS09850 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HCG51_RS09860 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HCG51_RS09870 ENOG4105BZ4 penicillin-binding protein HCG51_RS09885 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HCG51_RS09930 ENOG4105C01 Dihydroxy-acid dehydratase HCG51_RS09935 ENOG4105CPQ Dehydrogenase HCG51_RS09950 ENOG4105XCI PucC protein HCG51_RS09985 ENOG4105DWF phosphomethylpyrimidine kinase HCG51_RS10000 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HCG51_RS10005 ENOG4107YX3 NADH dehydrogenase subunit j HCG51_RS10010 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HCG51_RS10015 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HCG51_RS10055 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HCG51_RS10070 ENOG4105M3Z response regulator HCG51_RS10090 ENOG4105F4R Transcriptional regulator mode HCG51_RS10095 ENOG4108W3Y Transcriptional regulator, Crp Fnr family HCG51_RS10135 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HCG51_RS10145 ENOG4105BZU Histidine kinase HCG51_RS10155 ENOG4108JJA ABC, transporter HCG51_RS10210 ENOG4105BZU Histidine kinase HCG51_RS10220 ENOG4105WH1 Two component transcriptional regulator luxr family HCG51_RS10235 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HCG51_RS10260 ENOG4105C09 Bile acid HCG51_RS10265 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HCG51_RS10310 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HCG51_RS10320 ENOG410841Q phosphoesterase PA-phosphatase related protein HCG51_RS10365 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HCG51_RS10400 ENOG4107ZBH radical SAM domain protein HCG51_RS10430 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HCG51_RS10465 ENOG4105C42 Type I secretion membrane fusion protein (HlyD HCG51_RS10485 ENOG4105DGI Alkaline phosphatase HCG51_RS10510 ENOG4107YCR Transcriptional regulator, ARSR family HCG51_RS10515 ENOG4105D6J arsenicaL-resistance protein HCG51_RS10735 ENOG4105CEY Amp-dependent synthetase and ligase HCG51_RS10765 ENOG4105D8X mechanosensitive ion channel HCG51_RS10835 ENOG4105EY8 ABC transporter HCG51_RS10910 ENOG4107S6X Glycosyl transferase, family 2 HCG51_RS10915 ENOG4107T8Q Glycosyl transferase (Group 1 HCG51_RS10950 ENOG4105C6X Major Facilitator HCG51_RS10995 ENOG4108U78 Glutathione S-transferase HCG51_RS11035 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HCG51_RS11045 ENOG4105BZU Histidine kinase HCG51_RS11050 ENOG4105DGI Alkaline phosphatase HCG51_RS11250 ENOG4105K70 DNA-binding protein HCG51_RS11275 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HCG51_RS11305 ENOG4105KCF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) HCG51_RS11365 ENOG4105EKQ RNA-directed DNA polymerase HCG51_RS11420 ENOG4105CDU Replicative dna helicase HCG51_RS11420 ENOG4105CDU Replicative dna helicase HCG51_RS11460 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HCG51_RS11540 ENOG4105FAV ABC, transporter HCG51_RS11545 ENOG4105FDK ABC transporter HCG51_RS11550 ENOG4105DSE periplasmic solute binding protein HCG51_RS11555 ENOG4108PWY Carbohydrate-selective porin OprB HCG51_RS11565 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HCG51_RS11590 ENOG4105CNF WD-40 repeat protein HCG51_RS11620 ENOG4105E1F short-chain dehydrogenase reductase HCG51_RS11650 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HCG51_RS11670 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HCG51_RS11695 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HCG51_RS11705 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HCG51_RS11710 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HCG51_RS11715 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HCG51_RS11720 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HCG51_RS11730 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HCG51_RS11735 ENOG4105CQC Prephenate dehydratase HCG51_RS11740 ENOG4108XAD Protein of unknown function (DUF1997) HCG51_RS11745 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HCG51_RS11755 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HCG51_RS11780 ENOG4105J3Z Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HCG51_RS11825 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HCG51_RS11850 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HCG51_RS11855 ENOG4105EEX Two component transcriptional regulator (Winged helix family HCG51_RS11865 ENOG4105CNF WD-40 repeat protein HCG51_RS11905 ENOG4105DFF Rod shape-determining protein mreb HCG51_RS11910 ENOG41080E3 single-stranded DNA-binding protein HCG51_RS11935 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HCG51_RS11940 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HCG51_RS11980 ENOG4105KC4 UPF0296 protein HCG51_RS11995 ENOG4106AST May help in the organization of the PsaE and PsaF subunits (By similarity) HCG51_RS12005 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HCG51_RS12010 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HCG51_RS12040 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HCG51_RS12045 ENOG4105BZU Histidine kinase HCG51_RS12065 ENOG4108JIS Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HCG51_RS12085 ENOG4105D52 delta-aminolevulinic acid dehydratase HCG51_RS12095 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HCG51_RS12115 ENOG4105M3Z response regulator HCG51_RS12120 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HCG51_RS12125 ENOG4105BZU Histidine kinase HCG51_RS12130 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HCG51_RS12175 ENOG4105CPQ Dehydrogenase HCG51_RS12185 ENOG4105CPK Glycosyl transferase (Group 1 HCG51_RS12200 ENOG4105C42 Type I secretion membrane fusion protein (HlyD HCG51_RS12200 ENOG4105C42 Type I secretion membrane fusion protein (HlyD HCG51_RS12235 ENOG4105BZU Histidine kinase HCG51_RS12245 ENOG4105E4C Lytic transglycosylase catalytic HCG51_RS12255 ENOG4108Z7R Chaperone CsaA HCG51_RS12290 ENOG4105EWK phytoene HCG51_RS12300 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) HCG51_RS12325 ENOG41084H8 Binds directly to 16S ribosomal RNA (By similarity) HCG51_RS12345 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HCG51_RS12365 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HCG51_RS12375 ENOG4105D74 hydrolase HCG51_RS12380 ENOG4108TM9 integral membrane protein HCG51_RS12385 ENOG4105F32 YngK protein HCG51_RS12395 ENOG4105BZU Histidine kinase HCG51_RS12410 ENOG4105BZU Histidine kinase HCG51_RS12420 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HCG51_RS12435 ENOG41086VY Fic/DOC family HCG51_RS12460 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HCG51_RS12480 ENOG4105C5S asparaginyl-tRNA synthetase HCG51_RS12505 ENOG4105CNF WD-40 repeat protein HCG51_RS12530 ENOG4105C72 UPF0176 protein HCG51_RS12545 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HCG51_RS12555 ENOG4107S1Q Phosphatase HCG51_RS12590 ENOG4108VB1 regulatoR HCG51_RS12595 ENOG4105C0H protease HCG51_RS12625 ENOG4105D5K Hemolysin activator protein HCG51_RS12670 ENOG4105BZU Histidine kinase HCG51_RS12740 ENOG4105D0M Protease HtpX homolog HCG51_RS12780 ENOG4108JJA ABC, transporter HCG51_RS12800 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold HCG51_RS12860 ENOG4105VFU Rna-binding protein HCG51_RS12875 ENOG410841Q phosphoesterase PA-phosphatase related protein HCG51_RS12880 ENOG4105RHY Pfam:UPF0157 HCG51_RS12885 ENOG4105DSE periplasmic solute binding protein HCG51_RS12890 ENOG4105E98 transcriptional regulator DeoR family HCG51_RS12895 ENOG4108IUS Transketolase HCG51_RS12930 ENOG4105CVJ phosphoglycerate mutase HCG51_RS12950 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HCG51_RS12965 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HCG51_RS13005 ENOG4105D65 subunit l HCG51_RS13010 ENOG4108V9Q carbonic anhydrase HCG51_RS13015 ENOG4105C8S subunit m HCG51_RS13060 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HCG51_RS13065 ENOG4105EQQ protein containing aminopeptidase domain HCG51_RS13070 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HCG51_RS13080 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HCG51_RS13085 ENOG4107W19 lmbE family HCG51_RS13090 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HCG51_RS13105 ENOG4105C8T Leucyl-tRNA synthetase HCG51_RS13120 ENOG4105EMN RNA polymerase sigma factor HCG51_RS13130 ENOG4108PXI ErfK YbiS YcfS YnhG HCG51_RS13190 ENOG4105BZU Histidine kinase HCG51_RS13205 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HCG51_RS13210 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HCG51_RS13215 ENOG4105D9P serine threonine protein kinase HCG51_RS13225 ENOG4105BZU Histidine kinase HCG51_RS13230 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HCG51_RS13250 ENOG4105DRS transport system, permease HCG51_RS13260 ENOG4108UQX Low-potential cytochrome c that plays a role in the oxygen-evolving complex of photosystem II (By similarity) HCG51_RS13265 ENOG4108Z61 cytochrome c-550 HCG51_RS13270 ENOG4105H0N Participates in electron transfer between P700 and the cytochrome b6-f complex in photosystem I HCG51_RS13280 ENOG4105F8J Adenylate Guanylate cyclase HCG51_RS13330 ENOG4105KD7 acetyltransferase HCG51_RS13335 ENOG4105CPQ Dehydrogenase HCG51_RS13340 ENOG4105CJ3 phosphate transporter HCG51_RS13350 ENOG4108K9Q Controls heterocyst differentiation. Has both a protease and a DNA-binding activity (By similarity) HCG51_RS13365 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HCG51_RS13395 ENOG4107U9T Pfam:Ribonuclease_BN HCG51_RS13425 ENOG4105BZU Histidine kinase HCG51_RS13500 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HCG51_RS13515 ENOG4105CHV Transcription elongation factor NusA HCG51_RS13520 ENOG4107ZR3 Required for maturation of 30S ribosomal subunits (By similarity) HCG51_RS13555 ENOG4108V5V Serine Threonine protein kinase HCG51_RS13595 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HCG51_RS13600 ENOG4105M6F mutator MutT protein HCG51_RS13610 ENOG4105WVZ Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HCG51_RS13615 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HCG51_RS13620 ENOG4108NWW ferritin dps family protein HCG51_RS13660 ENOG4108IV0 ABC, transporter HCG51_RS13665 ENOG4105C0Z ABC transporter HCG51_RS13675 ENOG4105C32 Amino acid ABC transporter (Permease) HCG51_RS13680 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein HCG51_RS13690 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HCG51_RS13720 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase HCG51_RS13725 ENOG4107WDG serine threonine protein kinase HCG51_RS13740 ENOG41063NY Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HCG51_RS13750 ENOG4105DDG Cyanophycinase HCG51_RS13760 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HCG51_RS13765 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HCG51_RS13770 ENOG4108J59 Extracellular solute-binding protein, family 5 HCG51_RS13775 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase HCG51_RS13785 ENOG4105CH7 arginosuccinase HCG51_RS13825 ENOG4105CNW domain protein HCG51_RS13830 ENOG4105CNW domain protein HCG51_RS13835 ENOG4105VFU Rna-binding protein HCG51_RS13840 ENOG4108Y85 Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins (By similarity) HCG51_RS13850 ENOG4105BZS acriflavin resistance protein HCG51_RS13855 ENOG4105K64 Glycosyl transferase, family 2 HCG51_RS13860 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HCG51_RS13880 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HCG51_RS13885 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HCG51_RS13895 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HCG51_RS13905 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HCG51_RS13910 ENOG4105CAU Arsenical resistance protein, ArsH HCG51_RS13925 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HCG51_RS13935 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HCG51_RS13945 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HCG51_RS13965 ENOG4105CDA abc transporter atp-binding protein HCG51_RS13970 ENOG4105E5Q amino acid AbC transporter HCG51_RS13975 ENOG4105CNF WD-40 repeat protein HCG51_RS13980 ENOG4105D9P serine threonine protein kinase HCG51_RS14010 ENOG410834F Transcriptional regulator HCG51_RS14065 ENOG4108NVR Methyl-accepting chemotaxis HCG51_RS14080 ENOG4108UNF response regulator HCG51_RS14090 ENOG4107UAN Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HCG51_RS14105 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HCG51_RS14110 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HCG51_RS14115 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HCG51_RS14155 ENOG4107STW synthase HCG51_RS14190 ENOG4105CHR reductase HCG51_RS14195 ENOG4105VCQ rubredoxin HCG51_RS14210 ENOG4105F32 YngK protein HCG51_RS14215 ENOG4105D9P serine threonine protein kinase HCG51_RS14220 ENOG4105C4W S-formylglutathione hydrolase HCG51_RS14245 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HCG51_RS14285 ENOG4107ZYR domain protein HCG51_RS14295 ENOG4105CZN Potassium uptake protein HCG51_RS14325 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HCG51_RS14330 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HCG51_RS14365 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HCG51_RS14375 ENOG41084IE Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HCG51_RS14390 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HCG51_RS14435 ENOG4105FBB Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) (By similarity) HCG51_RS14465 ENOG4107YJ4 chain length determinant protein HCG51_RS14490 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HCG51_RS14495 ENOG4105CPK Glycosyl transferase (Group 1 HCG51_RS14505 ENOG4108SHN Glycosyl transferase, family 2 HCG51_RS14510 ENOG4105X1N Glycosyl transferase family 8 HCG51_RS14515 ENOG4105CKK Glycosyl transferase, family 2 HCG51_RS14525 ENOG4105PSV Polysaccharide Biosynthesis Protein HCG51_RS14530 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family HCG51_RS14550 ENOG4105D0M Protease HtpX homolog HCG51_RS14555 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HCG51_RS14580 ENOG4105C0F tryptophanase EC 4.1.99.1 HCG51_RS14595 ENOG4105EY5 This is one of the two reaction center proteins of photosystem II HCG51_RS14610 ENOG4105BZU Histidine kinase HCG51_RS14640 ENOG41090HT Inherit from COG: transposase HCG51_RS14645 ENOG41067D0 Antitoxin component of a toxin-antitoxin (TA) module. Upon expression in M.smegmatis neutralizes the effect of toxin RelE2 HCG51_RS14655 ENOG4108HMN Caspase domain HCG51_RS14680 ENOG4105JZI cytochrome P450 HCG51_RS14705 ENOG4105BZU Histidine kinase HCG51_RS14725 ENOG4105CXN decarboxylase HCG51_RS14740 ENOG4108IJ6 ABC transporter HCG51_RS14750 ENOG4108IYU L-aspartate oxidase HCG51_RS14780 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HCG51_RS14800 ENOG4105BZU Histidine kinase HCG51_RS14805 ENOG4105CVB Vitamin K epoxide reductase HCG51_RS14815 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HCG51_RS14830 ENOG4105CFG Acts as a chaperone (By similarity) HCG51_RS14835 ENOG4107GD3 Catalyzes the conversion of acetoacetate to acetone and carbon dioxide (By similarity) HCG51_RS14845 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HCG51_RS14865 ENOG4105CJN penicillin-binding protein HCG51_RS14870 ENOG4105K8N protein family UPF0079, ATPase HCG51_RS14875 ENOG4105CHW UPF0052 protein HCG51_RS14880 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HCG51_RS14900 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HCG51_RS14905 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HCG51_RS14920 ENOG4108RSN SNARE associated Golgi HCG51_RS14935 ENOG4105C32 Amino acid ABC transporter (Permease) HCG51_RS14950 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HCG51_RS14955 ENOG4105C0Z ABC transporter HCG51_RS14960 ENOG4108IV0 ABC, transporter HCG51_RS14980 ENOG4105CHC glucokinase (EC 2.7.1.2) HCG51_RS14995 ENOG4105C8S subunit m HCG51_RS15005 ENOG4105K63 Thioredoxin HCG51_RS15015 ENOG4105DUM transcriptional regulator, lysR family HCG51_RS15030 ENOG4105CVA phosphate HCG51_RS15045 ENOG410667J hydrolase HCG51_RS15085 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HCG51_RS15110 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HCG51_RS15125 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HCG51_RS15130 ENOG4105EB3 Histidine kinase HCG51_RS15140 ENOG4108W3Y Transcriptional regulator, Crp Fnr family HCG51_RS15145 ENOG4108PWY Carbohydrate-selective porin OprB HCG51_RS15160 ENOG4107VDP teichoic acid biosynthesis HCG51_RS15170 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HCG51_RS15175 ENOG4105J0U photosystem II HCG51_RS15200 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HCG51_RS15205 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HCG51_RS15210 ENOG4105E0Y RtcB Protein HCG51_RS15215 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HCG51_RS15220 ENOG4105C09 Bile acid HCG51_RS15225 ENOG4105CPC Aldo Keto reductase HCG51_RS15240 ENOG4105E0R Deoxyhypusine synthase HCG51_RS15265 ENOG4105JZI cytochrome P450 HCG51_RS15280 ENOG4105DQR SNARE associated Golgi HCG51_RS15305 ENOG4105H0Z Hemerythrin HHE cation binding domain protein HCG51_RS15335 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HCG51_RS15360 ENOG4107TCE N-acetyltransferase HCG51_RS15375 ENOG4108TQ9 Histidine kinase HCG51_RS15395 ENOG4105BZ1 (ABC) transporter HCG51_RS15430 ENOG410848D S4 domain protein YaaA HCG51_RS15445 ENOG4105D3Q Sugar transferase HCG51_RS15450 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family HCG51_RS15465 ENOG4105ES5 Histidine kinase HCG51_RS15520 ENOG4105BZU Histidine kinase HCG51_RS15545 ENOG4107YJ4 chain length determinant protein HCG51_RS15560 ENOG4105C0K Gdp-mannose 4,6-dehydratase HCG51_RS15570 ENOG4105EY8 ABC transporter HCG51_RS15610 ENOG4108IAJ Nad-dependent epimerase dehydratase HCG51_RS15630 ENOG4105CPK Glycosyl transferase (Group 1 HCG51_RS15645 ENOG4105CKK Glycosyl transferase, family 2 HCG51_RS15655 ENOG4107RA4 Glycosyl transferase (Group 1 HCG51_RS15665 ENOG4107RJ7 Glycosyl transferase (Group 1 HCG51_RS15670 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase HCG51_RS15675 ENOG4106WTF Glycosyl transferase, family 2 HCG51_RS15690 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HCG51_RS15705 ENOG4105CKK Glycosyl transferase, family 2 HCG51_RS15715 ENOG4108IAJ Nad-dependent epimerase dehydratase HCG51_RS15725 ENOG4105E5J UV damage endonuclease HCG51_RS15730 ENOG4105CFG Acts as a chaperone (By similarity) HCG51_RS15745 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HCG51_RS15810 ENOG4105CPC Aldo Keto reductase HCG51_RS15820 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) HCG51_RS15915 ENOG4105MXK Carbon dioxide concentrating mechanism protein HCG51_RS15920 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HCG51_RS15925 ENOG4108WT6 Carbon dioxide concentrating mechanism protein HCG51_RS15935 ENOG4105D65 subunit l HCG51_RS15950 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HCG51_RS15980 ENOG4105CNF WD-40 repeat protein HCG51_RS15985 ENOG4108Z86 Glutamine amidotransferase HCG51_RS16000 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HCG51_RS16010 ENOG4108IXY short-chain dehydrogenase reductase HCG51_RS16060 ENOG4105EHU Circadian clock protein KaiC HCG51_RS16070 ENOG4108WXF Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it enhances the phosphorylation status of KaiC. In contrast, the presence of KaiB in the complex decreases the phosphorylation status of KaiC, suggesting that KaiB acts by antagonizing the interaction between KaiA and KaiC. A KaiA dimer is sufficient to enhance KaiC hexamer phosphorylation HCG51_RS16075 ENOG4105BZU Histidine kinase HCG51_RS16080 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HCG51_RS16100 ENOG4105ETX regulatoR HCG51_RS16170 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HCG51_RS16175 ENOG410811H Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) HCG51_RS16180 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HCG51_RS16185 ENOG4108IV0 ABC, transporter HCG51_RS16190 ENOG4108V9Q carbonic anhydrase HCG51_RS16195 ENOG4105BZU Histidine kinase HCG51_RS16200 ENOG4105E5G Alpha beta hydrolase fold HCG51_RS16215 ENOG4105C8Y Acetylornithine aminotransferase HCG51_RS16225 ENOG4105BZU Histidine kinase HCG51_RS16230 ENOG4105BZU Histidine kinase HCG51_RS16250 ENOG4105D5D udp-galactopyranose mutase HCG51_RS16275 ENOG4105FFC UPF0187 protein HCG51_RS16280 ENOG4107VAM peptidase, m28 HCG51_RS16325 ENOG4107QSS Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli (By similarity) HCG51_RS16380 ENOG41082AN stage II sporulation protein HCG51_RS16385 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HCG51_RS16395 ENOG4105BZU Histidine kinase HCG51_RS16410 ENOG4108DJF Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HCG51_RS16425 ENOG4105BZU Histidine kinase HCG51_RS16460 ENOG4105IQJ Involved in biosynthesis of the thiamine precursor thiazole (By similarity) HCG51_RS16505 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HCG51_RS16515 ENOG4108JQ6 ABC transporter HCG51_RS16520 ENOG4107WDG serine threonine protein kinase HCG51_RS16565 ENOG4105BZ1 (ABC) transporter HCG51_RS16595 ENOG4105BZU Histidine kinase HCG51_RS16640 ENOG4105F2W methyltransferase HCG51_RS16665 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HCG51_RS16695 ENOG4105RAK Histidine kinase HCG51_RS16725 ENOG4105CJ1 ABC, transporter HCG51_RS16775 ENOG4105CZX twitching motility protein HCG51_RS16785 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HCG51_RS16790 ENOG4108UNF response regulator HCG51_RS16800 ENOG4105BZU Histidine kinase HCG51_RS16810 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HCG51_RS16815 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HCG51_RS16875 ENOG4105D9P serine threonine protein kinase HCG51_RS16920 ENOG4105BZU Histidine kinase HCG51_RS17000 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HCG51_RS17020 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HCG51_RS17030 ENOG4108Z6B deaminase HCG51_RS17045 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HCG51_RS17065 ENOG4105EMU Dehydrogenase HCG51_RS17100 ENOG41086DT Membrane protein of unknown function HCG51_RS17115 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HCG51_RS17125 ENOG4105DJZ UPF0182 protein HCG51_RS17140 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HCG51_RS17160 ENOG4107QWP ABC-2 type transporter HCG51_RS17165 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A HCG51_RS17175 ENOG4105CJ1 ABC, transporter HCG51_RS17180 ENOG4105CJ1 ABC, transporter HCG51_RS17190 ENOG4105D0S secretion protein (HlyD HCG51_RS17235 ENOG4105C3G gtp-binding protein HCG51_RS17245 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) HCG51_RS17265 ENOG4105VFU Rna-binding protein HCG51_RS17270 ENOG4105VFU Rna-binding protein HCG51_RS17280 ENOG4105DGI Alkaline phosphatase HCG51_RS17305 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 HCG51_RS17320 ENOG4105C19 ABC transporter HCG51_RS17335 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HCG51_RS17340 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HCG51_RS17360 ENOG4105WVZ Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HCG51_RS17365 ENOG4105C7H Helicase, RecD TraA family HCG51_RS17400 ENOG4105C9B Cysteine desulfurase HCG51_RS17405 ENOG4105WH1 Two component transcriptional regulator luxr family HCG51_RS17435 ENOG4105E4C Lytic transglycosylase catalytic HCG51_RS17440 ENOG4108R6K riboflavin synthase, subunit alpha HCG51_RS17460 ENOG4108PWY Carbohydrate-selective porin OprB HCG51_RS17465 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HCG51_RS17500 ENOG4108IJ6 ABC transporter HCG51_RS17505 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HCG51_RS17515 ENOG4108SMZ Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins (By similarity) HCG51_RS17525 ENOG4105CUJ penicillin amidase HCG51_RS17535 ENOG4105CVS RNA methyltransferase TrmH family, group 1 HCG51_RS17545 ENOG4105MSA Photosystem II reaction center W protein HCG51_RS17605 ENOG4105PNM synthesis protein HCG51_RS17610 ENOG4105VFU Rna-binding protein HCG51_RS17630 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HCG51_RS17660 ENOG4106MP8 UPF0754 membrane protein HCG51_RS17670 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HCG51_RS17680 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HCG51_RS17685 ENOG4105E2Z phosphate ABC transporter (Permease HCG51_RS17690 ENOG4105C8U phosphate abc transporter HCG51_RS17695 ENOG4105PWN phosphate abc transporter HCG51_RS17700 ENOG4108UMY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HCG51_RS17715 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HCG51_RS17720 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HCG51_RS17745 ENOG4105BZU Histidine kinase HCG51_RS17750 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HCG51_RS17830 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HCG51_RS17860 ENOG4107SC0 ferredoxin--NADP reductase HCG51_RS17875 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HCG51_RS17880 ENOG4105BZU Histidine kinase HCG51_RS17890 ENOG41061CK Antibiotic biosynthesis monooxygenase HCG51_RS17930 ENOG4107QV2 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HCG51_RS17945 ENOG4107QRI Phosphoketolase HCG51_RS17950 ENOG41080P6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HCG51_RS17955 ENOG4105JKW Valine--pyruvate aminotransferase HCG51_RS17960 ENOG4107QPD alcohol dehydrogenase HCG51_RS18060 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HCG51_RS18080 ENOG4105K64 Glycosyl transferase, family 2 HCG51_RS18085 ENOG4107QPH glycogen) synthase HCG51_RS18090 ENOG4105BZ1 (ABC) transporter HCG51_RS18095 ENOG4105D3Q Sugar transferase HCG51_RS18100 ENOG4107YJ4 chain length determinant protein HCG51_RS18105 ENOG4108TJN glycosyl transferase group 1 HCG51_RS18115 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HCG51_RS18125 ENOG4107XZA Glycosyl transferase family 2 HCG51_RS18130 ENOG4105CMR udp-glucose 4-epimerase HCG51_RS18135 ENOG4105D5U fad dependent oxidoreductase HCG51_RS18140 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HCG51_RS18155 ENOG4108M24 von Willebrand factor, type A HCG51_RS18160 ENOG4108UNF response regulator HCG51_RS18165 ENOG4105M3Z response regulator HCG51_RS18175 ENOG4105BZU Histidine kinase HCG51_RS18200 ENOG41081F0 Precorrin-8x methylmutase HCG51_RS18210 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HCG51_RS18220 ENOG4105CMS peptidase U62, modulator of DNA gyrase HCG51_RS18235 ENOG4105CKI cobalamin synthesis protein HCG51_RS18245 ENOG4105MSA Photosystem II reaction center W protein HCG51_RS18250 ENOG4105EPU Molybdenum cofactor synthesis domain protein HCG51_RS18255 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HCG51_RS18275 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HCG51_RS18280 ENOG4105X1F electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon- concentration (By similarity) HCG51_RS18285 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HCG51_RS18315 ENOG4107RNI Glucose 6-phosphate dehydrogenase effector OpcA HCG51_RS18320 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HCG51_RS18325 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HCG51_RS18335 ENOG4105VFU Rna-binding protein HCG51_RS18340 ENOG4105X25 HCG51_RS18355 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HCG51_RS18360 ENOG4105D7W serine acetyltransferase HCG51_RS18385 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HCG51_RS18405 ENOG4107YCR Transcriptional regulator, ARSR family HCG51_RS18415 ENOG4105C0Z ABC transporter HCG51_RS18420 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HCG51_RS18435 ENOG4105C89 phosphohexose isomerase HCG51_RS18440 ENOG4105DS4 PAS PAC sensor Signal transduction histidine kinase HCG51_RS18450 ENOG4107WDG serine threonine protein kinase HCG51_RS18455 ENOG4107WDG serine threonine protein kinase HCG51_RS18465 ENOG4107WDG serine threonine protein kinase HCG51_RS18470 ENOG4105IDI abc transporter atp-binding protein HCG51_RS18475 ENOG4108XKQ CRISPR-associated protein, Cas6-related HCG51_RS18490 ENOG4108YN7 fruiting body developmental protein HCG51_RS18650 ENOG4107WDG serine threonine protein kinase HCG51_RS18660 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HCG51_RS18670 ENOG4105CPC Aldo Keto reductase HCG51_RS18695 ENOG4108MJN Glycosyl Transferase HCG51_RS18710 ENOG4105CPK Glycosyl transferase (Group 1 HCG51_RS18715 ENOG4105D3Q Sugar transferase HCG51_RS18720 ENOG4108HMN Caspase domain HCG51_RS18745 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HCG51_RS18750 ENOG41083MR nifu domain-containing protein HCG51_RS18795 ENOG4105D3Q Sugar transferase HCG51_RS18805 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) HCG51_RS18820 ENOG4105FIK Inherit from COG: dihydropteroate synthase HCG51_RS18835 ENOG4105BZU Histidine kinase HCG51_RS18840 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HCG51_RS18845 ENOG4107Z8V Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HCG51_RS18860 ENOG4105D7N magnesium and cobalt transport protein CorA HCG51_RS18870 ENOG4107QSQ Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HCG51_RS18875 ENOG4105D9U N-acetyltransferase HCG51_RS18880 ENOG4105CNG UPF0061 protein HCG51_RS18890 ENOG4105DBI uridine monophosphokinase HCG51_RS18905 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HCG51_RS18910 ENOG4105CD8 aminopeptidase N HCG51_RS18920 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HCG51_RS18950 ENOG4108PWY Carbohydrate-selective porin OprB HCG51_RS18965 ENOG4105VUV UPF0367 protein HCG51_RS18970 ENOG4108JJB ABC transporter HCG51_RS18975 ENOG4105M0M Tetracycline resistance protein HCG51_RS18985 ENOG4107791 aminotransferase class V HCG51_RS18995 ENOG4105QYV Membrane HCG51_RS19005 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HCG51_RS19020 ENOG4105D05 Receptor HCG51_RS19035 ENOG4105BZU Histidine kinase HCG51_RS19060 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HCG51_RS19080 ENOG4105BZU Histidine kinase HCG51_RS19090 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HCG51_RS19105 ENOG4105C3J Cysteine desulfurase HCG51_RS19115 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HCG51_RS19120 ENOG4105D9P serine threonine protein kinase HCG51_RS19130 ENOG4107EFQ arachidonate 15-lipoxygenase HCG51_RS19135 ENOG4105CVP deoxyribo-dipyrimidine photolyase HCG51_RS19195 ENOG4105CPC Aldo Keto reductase HCG51_RS19210 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HCG51_RS19235 ENOG4108ZF3 Phosphatase HCG51_RS19265 ENOG4105DRS transport system, permease HCG51_RS19270 ENOG410612X Catalyzes the decarbonylation of fatty aldehydes to alkanes. Requires the presence of ferredoxin, ferredoxin reductase and NADPH for in vitro decarbonylase activity (By similarity). Involved in the biosynthesis of alkanes, mainly heptadecane and pentadecane HCG51_RS19280 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HCG51_RS19290 ENOG4105EUJ GTP cyclohydrolase i HCG51_RS19300 ENOG4105VGQ Photosystem I subunit X HCG51_RS19370 ENOG4105CXI aluminum resistance protein HCG51_RS19375 ENOG4106I2R Coenzyme F420 hydrogenase dehydrogenase, beta HCG51_RS19420 ENOG4108JQC penicillin-binding protein 1A HCG51_RS19440 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HCG51_RS19490 ENOG4105C9U ATP-dependent DNA helicase RecQ HCG51_RS19505 ENOG4105EVY Uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent (By similarity) HCG51_RS19535 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HCG51_RS19540 ENOG41084A0 50s ribosomal protein L35 HCG51_RS19565 ENOG4108JUA Transcriptional regulator HCG51_RS19580 ENOG4108UXN response regulator HCG51_RS19585 ENOG4105BZU Histidine kinase HCG51_RS19590 ENOG4105BZU Histidine kinase HCG51_RS19600 ENOG4105BZU Histidine kinase HCG51_RS19605 ENOG4105WH1 Two component transcriptional regulator luxr family HCG51_RS19615 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HCG51_RS19620 ENOG4105D9P serine threonine protein kinase HCG51_RS19660 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HCG51_RS19680 ENOG4107S5T Carbohydrate kinase HCG51_RS19705 ENOG4108VPT UPF0234 protein HCG51_RS19725 ENOG4105CND Glycosyl transferase, family 2 HCG51_RS19730 ENOG4105C6E dna polymerase iii HCG51_RS19745 ENOG4105KVH Transcriptional regulator HCG51_RS19760 ENOG4105C9X ppx gppa phosphatase HCG51_RS19790 ENOG41080HI glycine oxidase HCG51_RS19815 ENOG4105T2N Domain of unknown function (DUF2382) HCG51_RS19845 ENOG4108Z6M essential for photochemical activity. FB is the terminal electron acceptor of PSI, donating electrons to ferredoxin. The C-terminus interacts with PsaA B D and helps assemble the protein into the PSI complex. Required for binding of PsaD and PsaE to PSI. PSI is a plastocyanin cytochrome c6- ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn HCG51_RS19875 ENOG4105CQB FAD linked oxidase domain protein HCG51_RS19880 ENOG4105F8J Adenylate Guanylate cyclase HCG51_RS19885 ENOG4105F8J Adenylate Guanylate cyclase HCG51_RS19900 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HCG51_RS19950 ENOG4106KE4 Dehydrogenase HCG51_RS19970 ENOG4105G5N sensor protein HCG51_RS19985 ENOG4105W3H MtN3 and saliva related transmembrane protein HCG51_RS19990 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HCG51_RS20005 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HCG51_RS20010 ENOG4105VPX protein, conserved in bacteria HCG51_RS20025 ENOG4105DJY efflux transporter, rnd family, mfp subunit HCG51_RS20030 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HCG51_RS20035 ENOG4105C19 ABC transporter HCG51_RS20045 ENOG4105DJY efflux transporter, rnd family, mfp subunit HCG51_RS20050 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HCG51_RS20075 ENOG4108W6C Dehydrogenase HCG51_RS20085 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HCG51_RS20090 ENOG4105CNW domain protein HCG51_RS20100 ENOG4105CNW domain protein HCG51_RS20115 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HCG51_RS20135 ENOG4108HMX isocitrate dehydrogenase (NADP) HCG51_RS20165 ENOG4108JJB ABC transporter HCG51_RS20215 ENOG4105BZ1 (ABC) transporter HCG51_RS20225 ENOG4105CMR udp-glucose 4-epimerase HCG51_RS20235 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) HCG51_RS20240 ENOG4107VAM peptidase, m28 HCG51_RS20250 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HCG51_RS20260 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HCG51_RS20280 ENOG4108UNF response regulator HCG51_RS20295 ENOG4108IUZ ABC transporter HCG51_RS20320 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HCG51_RS20350 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin HCG51_RS20370 ENOG4105CRK lysyL-tRNA synthetase HCG51_RS20420 ENOG4105BZU Histidine kinase HCG51_RS20430 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HCG51_RS20460 ENOG4108PWY Carbohydrate-selective porin OprB HCG51_RS20465 ENOG4108PWY Carbohydrate-selective porin OprB HCG51_RS20480 ENOG4105C01 Dihydroxy-acid dehydratase HCG51_RS20485 ENOG4107RSM transcriptional regulator HCG51_RS20500 ENOG4105BZU Histidine kinase HCG51_RS20510 ENOG4105BZU Histidine kinase HCG51_RS20535 ENOG41068JE domain protein HCG51_RS20560 ENOG4105CSR polyphosphate kinase 2 HCG51_RS20575 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HCG51_RS20595 ENOG4105K46 50S ribosomal protein l27 HCG51_RS20600 ENOG41082FX This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HCG51_RS20645 ENOG4105GHY electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon- concentration (By similarity) HCG51_RS20660 ENOG4107R8N Glycosyl transferase, family 2 HCG51_RS20665 ENOG4105CN1 protease HCG51_RS20695 ENOG4105F8J Adenylate Guanylate cyclase HCG51_RS20700 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HCG51_RS20710 ENOG4108R6G acetyltransferase HCG51_RS20735 ENOG4105CRP Part of the ABC transporter FtsEX involved in HCG51_RS20750 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) HCG51_RS20760 ENOG41082AF Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HCG51_RS20770 ENOG4105DZP Membrane-associated zinc metalloprotease HCG51_RS20825 ENOG4105EYH Exonuclease HCG51_RS20865 ENOG4105CGZ zinc metallopeptidase HCG51_RS20910 ENOG4105C8M UPF0272 protein HCG51_RS20915 ENOG4107RTD sua5 ycio yrdc ywlc family protein HCG51_RS20925 ENOG4105CPC Aldo Keto reductase HCG51_RS20930 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HCG51_RS20940 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HCG51_RS20990 ENOG4105BZU Histidine kinase HCG51_RS21000 ENOG4108IQE Amp-dependent synthetase and ligase HCG51_RS21060 ENOG4105DB3 bacteriochlorophyll chlorophyll a synthase HCG51_RS21065 ENOG4105D0U Arsenite-activated ATPase (ArsA) HCG51_RS21085 ENOG4108TJN glycosyl transferase group 1 HCG51_RS21095 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HCG51_RS21220 ENOG4105CTK cobaltochelatase, cobn subunit HCG51_RS21240 ENOG4108VFZ ribulose bisphosphate carboxylase, small HCG51_RS21250 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate HCG51_RS21280 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HCG51_RS21305 ENOG4105VCQ rubredoxin HCG51_RS21310 ENOG4105CBX hi0933 family HCG51_RS21315 ENOG4105D3Q Sugar transferase HCG51_RS21325 ENOG4107QPH glycogen) synthase HCG51_RS21330 ENOG4105VFN O-Antigen polymerase HCG51_RS21335 ENOG4107RA4 Glycosyl transferase (Group 1 HCG51_RS21355 ENOG4107YJ4 chain length determinant protein HCG51_RS21365 ENOG4108UW5 maltose o-acetyltransferase HCG51_RS21370 ENOG4105BZU Histidine kinase HCG51_RS21390 ENOG4108IPT Naphthoate synthase HCG51_RS21410 ENOG4105C0R drug resistance transporter emrb qaca subfamily HCG51_RS21415 ENOG4107SDT Homocitrate synthase HCG51_RS21445 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HCG51_RS21475 ENOG4105DTQ mandelate racemase muconate lactonizing HCG51_RS21500 ENOG4108ISE 4Fe-4S ferredoxin, iron-sulfur binding HCG51_RS21520 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HCG51_RS21525 ENOG4105K63 Thioredoxin HCG51_RS21550 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HCG51_RS21555 ENOG4107RIS Acyl-transferase HCG51_RS21580 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HCG51_RS21585 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HCG51_RS21615 ENOG4105E4F Isochorismate synthase HCG51_RS21630 ENOG4105CEY Amp-dependent synthetase and ligase HCG51_RS21635 ENOG4105WGP Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl- CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis (By similarity) HCG51_RS21695 ENOG4108R9R May be involved in photosynthetic membrane biogenesis (By similarity) HCG51_RS21700 ENOG4108YH8 Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins (By similarity) HCG51_RS21705 ENOG41082AN stage II sporulation protein HCG51_RS21710 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) HCG51_RS21725 ENOG4105CNI cell division protein FtsW HCG51_RS21745 ENOG4108IAJ Nad-dependent epimerase dehydratase HCG51_RS21750 ENOG4105C6Y Udp-glucose 6-dehydrogenase HCG51_RS21765 ENOG4105CIK Amidinotransferase HCG51_RS21785 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HCG51_RS21790 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HCG51_RS21800 ENOG4105DKQ ROK family HCG51_RS21810 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HCG51_RS21815 ENOG4105C3M thioredoxin reductase HCG51_RS21825 ENOG4106855 Competence protein HCG51_RS21845 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase HCG51_RS21875 ENOG4105DTI Phosphonopyruvate decarboxylase HCG51_RS21910 ENOG4105BZU Histidine kinase HCG51_RS21915 ENOG4108R99 pseudouridine synthase HCG51_RS21920 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HCG51_RS21930 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HCG51_RS21950 ENOG4105C37 (CBS) domain HCG51_RS21955 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HCG51_RS21965 ENOG4107T5V SNARE associated Golgi HCG51_RS21985 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HCG51_RS22000 ENOG4105DWF phosphomethylpyrimidine kinase HCG51_RS22030 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HCG51_RS22035 ENOG4105CPC Aldo Keto reductase HCG51_RS22040 ENOG41067SE Tetr family transcriptional regulator HCG51_RS22065 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HCG51_RS22075 ENOG4105N82 Endonuclease HCG51_RS22080 ENOG4105E0U tyrosine-specific transport protein HCG51_RS22085 ENOG4105BZU Histidine kinase HCG51_RS22090 ENOG4105CD3 dihydroorotase HCG51_RS22105 ENOG4105CPQ Dehydrogenase HCG51_RS22115 ENOG4108K5P (LipO)protein HCG51_RS22125 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) HCG51_RS22140 ENOG4105DGU Histone deacetylase HCG51_RS22150 ENOG4105D64 Mechanosensitive ion channel HCG51_RS22165 ENOG4105CP9 extracellular ligand-binding receptor HCG51_RS22190 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HCG51_RS22210 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HCG51_RS22215 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HCG51_RS22220 ENOG4107TS3 membrane protein, TerC HCG51_RS22255 ENOG4105DC8 reductase HCG51_RS22260 ENOG4105IPS esterase HCG51_RS22295 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HCG51_RS22300 ENOG4105CNF WD-40 repeat protein HCG51_RS22355 ENOG4105C7Z Conserved Protein HCG51_RS22360 ENOG410801B Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HCG51_RS22400 ENOG4105E3B Multicopper oxidase HCG51_RS22405 ENOG4105G01 cobalamin (vitamin B12) biosynthesis CbiM protein HCG51_RS22415 ENOG4108JJB ABC transporter HCG51_RS22445 ENOG4108302 MgtC SapB transporter HCG51_RS22455 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HCG51_RS22460 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HCG51_RS22510 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HCG51_RS22535 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HCG51_RS22545 ENOG4108UK2 deaminase HCG51_RS22555 ENOG41066RC nucleoside 2-deoxyribosyltransferase HCG51_RS22565 ENOG4106QP8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HCG51_RS22575 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) HCG51_RS22580 ENOG4105Q36 FHA domain containing protein HCG51_RS22585 ENOG4105FCD Major Facilitator HCG51_RS22595 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HCG51_RS22645 ENOG4105C5I Dehydrogenase HCG51_RS22655 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HCG51_RS22680 ENOG4105BZU Histidine kinase HCG51_RS22715 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HCG51_RS22735 ENOG4105CEV competence damage-inducible protein HCG51_RS22740 ENOG4105ESV Glycosyl transferase, family 4 HCG51_RS22760 ENOG4105ERH Fumarylacetoacetate hydrolase HCG51_RS22765 ENOG41082BG Binds together with S18 to 16S ribosomal RNA (By similarity) HCG51_RS22815 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HCG51_RS22835 ENOG4105DC8 reductase HCG51_RS22845 ENOG4105DGI Alkaline phosphatase HCG51_RS22870 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HCG51_RS22895 ENOG4105WH1 Two component transcriptional regulator luxr family HCG51_RS22910 ENOG4105CD2 stage iii sporulation protein aa HCG51_RS22935 ENOG4105IJJ transcriptional regulator, crp fnr family HCG51_RS22955 ENOG4105BZU Histidine kinase HCG51_RS22960 ENOG4105KK4 UPF0060 membrane protein HCG51_RS22975 ENOG4105CE4 GlcNAc 6-P deacetylase HCG51_RS23000 ENOG4105M08 Membrane HCG51_RS23035 ENOG4107XW6 Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HCG51_RS23050 ENOG4107WDG serine threonine protein kinase HCG51_RS23080 ENOG4105DPX Hydrogenase, large subunit HCG51_RS23095 ENOG4105D82 Glutamate dehydrogenase HCG51_RS23115 ENOG4105C7K acetolactate synthase HCG51_RS23140 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HCG51_RS23160 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HCG51_RS23165 ENOG4105EMU Dehydrogenase HCG51_RS23180 ENOG4105ES5 Histidine kinase HCG51_RS23185 ENOG4105CUX Signal transduction histidine kinase HCG51_RS23190 ENOG4108PWY Carbohydrate-selective porin OprB HCG51_RS23225 ENOG4108UNV SUF system FeS assembly protein, NifU family HCG51_RS23235 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HCG51_RS23260 ENOG41083UI stage II sporulation protein HCG51_RS23270 ENOG41082AN stage II sporulation protein HCG51_RS23295 ENOG4105F8J Adenylate Guanylate cyclase HCG51_RS23310 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HCG51_RS23315 ENOG4107RNU major facilitator superfamily MFS_1 HCG51_RS23320 ENOG4105D7T ABC transporter HCG51_RS23335 ENOG4105I5W Transporter HCG51_RS23400 ENOG41072GX Peptidase M22 Glycoprotease HCG51_RS23435 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HCG51_RS23465 ENOG4105C9B Cysteine desulfurase HCG51_RS23505 ENOG4105C0R drug resistance transporter emrb qaca subfamily HCG51_RS23515 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HCG51_RS23525 ENOG4105CHF Glutathione S-transferase HCG51_RS23535 ENOG4105WH1 Two component transcriptional regulator luxr family HCG51_RS23565 ENOG4108JQ6 ABC transporter HCG51_RS23580 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit HCG51_RS23625 ENOG4105CKD glutathione-regulated potassium-efflux system protein HCG51_RS23635 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HCG51_RS23640 ENOG4105BZU Histidine kinase HCG51_RS23645 ENOG4105CVA phosphate HCG51_RS23685 ENOG4105CJ1 ABC, transporter HCG51_RS23700 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HCG51_RS23710 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HCG51_RS23725 ENOG4105CVN desaturase HCG51_RS23780 ENOG4105C59 p-type ATPase HCG51_RS23800 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HCG51_RS23855 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HCG51_RS23860 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HCG51_RS23885 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HCG51_RS23910 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HCG51_RS23920 ENOG4105CZX twitching motility protein HCG51_RS23940 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HCG51_RS23950 ENOG4108Z0R Transferase HCG51_RS23995 ENOG4108RXX maleylacetoacetate isomerase HCG51_RS24025 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HCG51_RS24055 ENOG4105C0D helicase HCG51_RS24065 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HCG51_RS24085 ENOG4108R0D protein with myosin-like HCG51_RS24090 ENOG4107RU9 Transcriptional regulator, Crp Fnr family HCG51_RS24095 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HCG51_RS24100 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HCG51_RS24105 ENOG4105DA5 (ABC) transporter HCG51_RS24110 ENOG4105DAY polysaccharide export protein HCG51_RS24130 ENOG4105CP7 Triose-phosphate isomerase HCG51_RS24135 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HCG51_RS24155 ENOG41082QS Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HCG51_RS24220 ENOG4108Z0Z intracellular protease Pfpi family HCG51_RS24250 ENOG4105WEF catalase HCG51_RS24270 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HCG51_RS24305 ENOG4105CMS peptidase U62, modulator of DNA gyrase HCG51_RS24335 ENOG4105VUN Transcriptional regulator HCG51_RS24355 ENOG4105BZU Histidine kinase HCG51_RS24365 ENOG4107KHP This protein is a component of the reaction center of photosystem II (By similarity) HCG51_RS24395 ENOG4105E7A Glutamine amidotransferase HCG51_RS24415 ENOG4106BTU phycobilisome rod-core linker polypeptide HCG51_RS24420 ENOG4107QI6 Cysteine desulfurase HCG51_RS24450 ENOG4107QT5 Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HCG51_RS24465 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HCG51_RS24505 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase HCG51_RS24520 ENOG4108RXX maleylacetoacetate isomerase HCG51_RS24525 ENOG4108RAV Conserved protein HCG51_RS24530 ENOG4108PPB Seems to be required for the assembly of the photosystem I complex (By similarity) HCG51_RS24535 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HCG51_RS24540 ENOG4105CHF Glutathione S-transferase HCG51_RS24575 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HCG51_RS24590 ENOG4105D75 Capsular exopolysaccharide family HCG51_RS24605 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HCG51_RS24620 ENOG4108IJ0 Aspartate ammonia-lyase HCG51_RS24640 ENOG4105F0N pyrophosphate phospho-hydrolase HCG51_RS24645 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HCG51_RS24655 ENOG4108I0Q anthranilate phosphoribosyltransferase HCG51_RS24660 ENOG4105F04 LysR family Transcriptional regulator HCG51_RS24670 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) HCG51_RS24675 ENOG4105D5K Hemolysin activator protein HCG51_RS24680 ENOG4105IB0 filamentous hemagglutinin family outer membrane protein HCG51_RS24685 ENOG4108UTZ Dihydroxyacetone kinase HCG51_RS24730 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HCG51_RS24735 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HCG51_RS24745 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HCG51_RS24750 ENOG410828V rubredoxin HCG51_RS24760 ENOG4105NT3 This b-type cytochrome is tightly associated with the reaction center of photosystem II and possibly is part of the water-oxidation complex (By similarity) HCG51_RS24765 ENOG410689D This b-type cytochrome is tightly associated with the reaction center of photosystem II and possibly is part of the water-oxidation complex (By similarity) HCG51_RS24775 ENOG4106DN3 This protein is a component of the reaction center of photosystem II (By similarity) HCG51_RS24800 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HCG51_RS24805 ENOG4105CPJ photosystem II manganese-stabilizing HCG51_RS24815 ENOG4108HMN Caspase domain HCG51_RS24835 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HCG51_RS24840 ENOG4105D7Z glutathione synthase HCG51_RS24855 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HCG51_RS24870 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HCG51_RS24905 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HCG51_RS24945 ENOG4107QN2 dihydrolipoyl dehydrogenase HCG51_RS24950 ENOG4107QZB decarboxylase HCG51_RS24955 ENOG4105K70 DNA-binding protein HCG51_RS24965 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HCG51_RS24975 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HCG51_RS24980 ENOG4108IAJ Nad-dependent epimerase dehydratase HCG51_RS25040 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HCG51_RS25065 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HCG51_RS25080 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HCG51_RS25095 ENOG4108IG5 Transcriptional regulator HCG51_RS25100 ENOG4108UVJ appr-1-p processing domain protein HCG51_RS25110 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HCG51_RS25120 ENOG4105WVZ Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HCG51_RS25135 ENOG4107RAJ Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HCG51_RS25145 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HCG51_RS25150 ENOG4105WS7 Cation transport regulator HCG51_RS25155 ENOG4105E5M Multidrug resistance protein D HCG51_RS25175 ENOG4108IJ6 ABC transporter HCG51_RS25180 ENOG4105EWK phytoene HCG51_RS25185 ENOG4107WDG serine threonine protein kinase HCG51_RS25195 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HCG51_RS25230 ENOG4105BZU Histidine kinase HCG51_RS25260 ENOG4106BTU phycobilisome rod-core linker polypeptide HCG51_RS25305 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) HCG51_RS25315 ENOG4107R7Y intracellular protease Pfpi family HCG51_RS25320 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) HCG51_RS25360 ENOG4107QJZ Glycosyl transferase, family 2 HCG51_RS25380 ENOG4105EY8 ABC transporter HCG51_RS25460 ENOG4105C7S Dehydrogenase HCG51_RS25500 ENOG4105CHH sulfate transporter HCG51_RS25545 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HCG51_RS25585 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HCG51_RS25590 ENOG4105NAN IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HCG51_RS25605 ENOG4108PJD permease HCG51_RS25610 ENOG4105BZU Histidine kinase HCG51_RS25625 ENOG4105CHR reductase HCG51_RS25665 ENOG4105F37 PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 HCG51_RS25700 ENOG4105D9P serine threonine protein kinase HCG51_RS25705 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HCG51_RS25720 ENOG4108IEH NADH dehydrogenase subunit g HCG51_RS25725 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HCG51_RS25740 ENOG4105CD5 CoA-binding domain protein HCG51_RS25750 ENOG4108X7A Terpene synthase metal-binding domain-containing protein HCG51_RS25755 ENOG4105JZI cytochrome P450 HCG51_RS25760 ENOG4105D9P serine threonine protein kinase HCG51_RS25770 ENOG4105PW4 Sugar fermentation stimulation protein homolog HCG51_RS25775 ENOG4105D7K pfkb domain protein HCG51_RS25785 ENOG4108TNP HCG51_RS25815 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HCG51_RS25820 ENOG4105C8B TIGR00159 family HCG51_RS25830 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HCG51_RS25840 ENOG4105CB5 ATP-dependent DNA helicase recG HCG51_RS25880 ENOG4105BZ4 penicillin-binding protein HCG51_RS25900 ENOG4105D9P serine threonine protein kinase HCG51_RS25905 ENOG4105CHR reductase HCG51_RS25915 ENOG4105BZ1 (ABC) transporter HCG51_RS25920 ENOG4105BZ1 (ABC) transporter HCG51_RS25930 ENOG4107XWB Zinc finger, swim domain protein HCG51_RS25950 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HCG51_RS25975 ENOG4105EET magnesium chelatase HCG51_RS25985 ENOG41080XM UPF0145 protein HCG51_RS26020 ENOG4105D9P serine threonine protein kinase HCG51_RS26030 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HCG51_RS26035 ENOG4107WDG serine threonine protein kinase HCG51_RS26040 ENOG4108062 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HCG51_RS26045 ENOG4105CH2 amidohydrolase HCG51_RS26055 ENOG4105CMT Dihydroxyacetone kinase HCG51_RS26080 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HCG51_RS26090 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HCG51_RS26125 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HCG51_RS26135 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HCG51_RS26140 ENOG41060D5 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HCG51_RS26215 ENOG4108GH0 ATP-binding protein yghT HCG51_RS26225 ENOG4105CG5 Glycosyl transferase (Group 1 HCG51_RS26230 ENOG4107SBE Glycosyl transferase (Group 1 HCG51_RS26235 ENOG4105D3Q Sugar transferase HCG51_RS26255 ENOG4108IXY short-chain dehydrogenase reductase HCG51_RS26260 ENOG41075E2 Photosystem I reaction centre subunit IX / PsaJ HCG51_RS26285 ENOG4105EMU Dehydrogenase HCG51_RS26310 ENOG4105DTD Dehydrogenase HCG51_RS26340 ENOG41081UC Inherit from COG: Competence protein HCG51_RS26350 ENOG4107Z12 Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HCG51_RS26365 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HCG51_RS26370 ENOG4107DVA This protein is a component of the reaction center of photosystem II (By similarity) HCG51_RS26380 ENOG4106DDF Photosystem II reaction center protein M HCG51_RS26395 ENOG4105BZU Histidine kinase HCG51_RS26400 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HCG51_RS26415 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HCG51_RS26435 ENOG41082AN stage II sporulation protein HCG51_RS26440 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HCG51_RS26490 ENOG4105C78 Uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent (By similarity) HCG51_RS26515 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HCG51_RS26525 ENOG4105I3K Ferric uptake regulator, Fur family HCG51_RS26600 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HCG51_RS26615 ENOG4105DXX methyltransferase HCG51_RS26650 ENOG4105BZU Histidine kinase HCG51_RS26660 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HCG51_RS26675 ENOG4108V3W Chemotaxis protein, CheW HCG51_RS26690 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HCG51_RS26695 ENOG4105BZU Histidine kinase HCG51_RS26730 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HCG51_RS26735 ENOG4108PWY Carbohydrate-selective porin OprB HCG51_RS26745 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HCG51_RS26760 ENOG4105RD7 BadF BadG BcrA BcrD HCG51_RS26790 ENOG4108Z03 MAF-like protein HCG51_RS26810 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HCG51_RS26830 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HCG51_RS26845 ENOG4105CKK Glycosyl transferase, family 2 HCG51_RS26855 ENOG4105C6X Major Facilitator HCG51_RS26905 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HCG51_RS26940 ENOG4105CTK cobaltochelatase, cobn subunit HCG51_RS27020 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HCG51_RS27025 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HCG51_RS27030 ENOG4107R7I amino acid HCG51_RS27035 ENOG4105BZU Histidine kinase HCG51_RS27050 ENOG4107BJW polysaccharide deacetylase HCG51_RS27065 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HCG51_RS27070 ENOG41080FP Hydrolase HCG51_RS27075 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HCG51_RS27090 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase HCG51_RS27100 ENOG4107R1X phosphohexokinase HCG51_RS27130 ENOG4105D9P serine threonine protein kinase HCG51_RS27135 ENOG4105D9P serine threonine protein kinase HCG51_RS27155 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HCG51_RS27160 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HCG51_RS27165 ENOG4108E2B had-superfamily hydrolase, subfamily iib HCG51_RS27170 ENOG4105C7B Threonine dehydratase HCG51_RS27190 ENOG4108I5U Uridine phosphorylase HCG51_RS27200 ENOG4105D5K Hemolysin activator protein HCG51_RS27270 ENOG4105C1J atp-dependent rna helicase HCG51_RS27295 ENOG4105D5K Hemolysin activator protein HCG51_RS27340 ENOG4105DN3 alpha-2-macroglobulin domain protein HCG51_RS27345 ENOG4108JQB penicillin-binding protein 1C HCG51_RS27365 ENOG4107FW0 short-chain dehydrogenase reductase HCG51_RS27375 ENOG4107QIZ NADH dehydrogenase HCG51_RS27400 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HCG51_RS27420 ENOG4107SCA Formamidase (EC 3.5.1.49) HCG51_RS27420 ENOG4107SCA Formamidase (EC 3.5.1.49) HCG51_RS27470 ENOG4105VG5 Membrane HCG51_RS27480 ENOG4105BZU Histidine kinase HCG51_RS27490 ENOG4105BZU Histidine kinase HCG51_RS27525 ENOG4105RRH HCG51_RS27530 ENOG410715G filament integrity protein HCG51_RS27535 ENOG4106D5S Corrinoid adenosyltransferase BtuR CobO CobP HCG51_RS27550 ENOG4105C5R Aminotransferase HCG51_RS27570 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HCG51_RS27610 ENOG4105BZU Histidine kinase HCG51_RS27615 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HCG51_RS27630 ENOG4105C8Q Methyl-accepting chemotaxis HCG51_RS27635 ENOG4108KTQ Methyltransferase HCG51_RS27675 ENOG4108K7V UPF0284 protein HCG51_RS27685 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HCG51_RS27695 ENOG4105D3Q Sugar transferase HCG51_RS27700 ENOG4105DRS transport system, permease HCG51_RS27710 ENOG4105CVM Molybdenum cofactor synthesis domain protein HCG51_RS27725 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HCG51_RS27820 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HCG51_RS27840 ENOG4105BZU Histidine kinase HCG51_RS27845 ENOG4105WH1 Two component transcriptional regulator luxr family HCG51_RS27855 ENOG4108Z6B deaminase HCG51_RS27860 ENOG4105EYW Ion transport protein HCG51_RS27885 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HCG51_RS27900 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HCG51_RS27925 ENOG4105CAY ferredoxin--nadp reductase HCG51_RS27940 ENOG4106PMH Extracellular solute-binding protein family 3 HCG51_RS27945 ENOG4107XKF NMT1 THI5 Like Domain Protein HCG51_RS27955 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HCG51_RS27975 ENOG4105UIB (ABC) transporter HCG51_RS27990 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HCG51_RS28015 ENOG4107VQD May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) HCG51_RS28020 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HCG51_RS28025 ENOG4105PGM cation diffusion facilitator family transporter HCG51_RS28045 ENOG4107TVC Glycosyl transferase, family 2 HCG51_RS28060 ENOG4108MV2 Involved in light-induced Na( )-dependent proton extrusion. Also seems to be involved in CO(2) transport (By similarity) HCG51_RS28070 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HCG51_RS28085 ENOG4105C0P Mg chelatase subunit ChlI HCG51_RS28090 ENOG4107YU2 histidine triad (hIT) protein HCG51_RS28095 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HCG51_RS28105 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HCG51_RS28110 ENOG4107XWZ ferric uptake regulator HCG51_RS28120 ENOG4105CTK cobaltochelatase, cobn subunit HCG51_RS28125 ENOG4105BZU Histidine kinase HCG51_RS28130 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) HCG51_RS28160 ENOG4105Y3U Transglycosylase-associated protein HCG51_RS28165 ENOG41063FQ CsbD-like protein HCG51_RS28185 ENOG4108RMU ferritin dps family protein HCG51_RS28190 ENOG41068BY Low temperature-induced protein HCG51_RS28210 ENOG4105BZU Histidine kinase HCG51_RS28245 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HCG51_RS28275 ENOG4105BZU Histidine kinase HCG51_RS28280 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HCG51_RS28295 ENOG4105CBS Chea signal transduction histidine kinase HCG51_RS28300 ENOG4105CHM Aminotransferase HCG51_RS28305 ENOG4105N6Y Thioredoxin HCG51_RS28380 ENOG4105CUT histidyl-tRNA synthetase HCG51_RS28385 ENOG4105CNV Aldolase HCG51_RS28390 ENOG4108UQ8 endoribonuclease L-psp HCG51_RS28400 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme HCG51_RS28420 ENOG4105CD3 dihydroorotase HCG51_RS28425 ENOG4105D9P serine threonine protein kinase HCG51_RS28475 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HCG51_RS28490 ENOG4107VXZ Hydrolase HCG51_RS28495 ENOG4105FDT acyl-CoA dehydrogenase HCG51_RS28500 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HCG51_RS28505 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HCG51_RS28520 ENOG4105BZU Histidine kinase HCG51_RS28525 ENOG4105BZU Histidine kinase HCG51_RS28530 ENOG4105D9P serine threonine protein kinase HCG51_RS28540 ENOG4107QRG dna polymerase iii HCG51_RS28550 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HCG51_RS28560 ENOG4105C75 arginyL-tRNA synthetase HCG51_RS28580 ENOG4107STW synthase HCG51_RS28610 ENOG4105BZU Histidine kinase HCG51_RS28660 ENOG4105EKQ RNA-directed DNA polymerase HCG51_RS28665 ENOG4105DZR Type I site-specific deoxyribonuclease HCG51_RS28735 ENOG4105E6M Sulphatase-modifying factor protein HCG51_RS28755 ENOG4105BZU Histidine kinase HCG51_RS28780 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HCG51_RS28785 ENOG4105DEG Vwa containing coxe family protein HCG51_RS28805 ENOG4105Y3U Transglycosylase-associated protein HCG51_RS28810 ENOG4105WEF catalase HCG51_RS28885 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) HCG51_RS28890 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HCG51_RS28895 ENOG4106H78 methyltransferase HCG51_RS28925 ENOG4105BZ1 (ABC) transporter HCG51_RS28975 ENOG4105CRE cytochrome C HCG51_RS28985 ENOG4105WH1 Two component transcriptional regulator luxr family HCG51_RS29000 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HCG51_RS29005 ENOG4108VIA integral membrane protein HCG51_RS29010 ENOG4106AG1 Involved in the binding and or turnover of quinones at the Q(B) site of Photosystem II (By similarity) HCG51_RS29030 ENOG4105E33 succinate dehydrogenase HCG51_RS29055 ENOG41083EU 50s ribosomal protein l28 HCG51_RS29085 ENOG4105CKK Glycosyl transferase, family 2 HCG51_RS29090 ENOG4105K64 Glycosyl transferase, family 2 HCG51_RS29280 ENOG4105WH1 Two component transcriptional regulator luxr family HCG51_RS29285 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HCG51_RS29290 ENOG4105BZU Histidine kinase HCG51_RS29300 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HCG51_RS29305 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HCG51_RS29310 ENOG4105WIA photosystem II reaction center protein H HCG51_RS29330 ENOG4105C9U ATP-dependent DNA helicase RecQ HCG51_RS29340 ENOG4107SGM protein serine threonine phosphatase HCG51_RS29360 ENOG4106WTF Glycosyl transferase, family 2 HCG51_RS29370 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HCG51_RS29385 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HCG51_RS29400 ENOG4105D75 Capsular exopolysaccharide family HCG51_RS29475 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HCG51_RS29480 ENOG4105C5F glutamine synthetase HCG51_RS29505 ENOG4105DU0 nucleoside hydrolase HCG51_RS29515 ENOG4108RVA ribokinase HCG51_RS29540 ENOG4105C5I Dehydrogenase HCG51_RS29545 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HCG51_RS29550 ENOG4106WTF Glycosyl transferase, family 2 HCG51_RS29590 ENOG4105WCA Ferredoxin HCG51_RS29620 ENOG4105ND9 Nitrogenase-associated protein HCG51_RS29635 ENOG4105E6M Sulphatase-modifying factor protein HCG51_RS29650 ENOG4105E6M Sulphatase-modifying factor protein HCG51_RS29685 ENOG4105DEN Luciferase family HCG51_RS29695 ENOG4108KQJ Type 11 methyltransferase HCG51_RS29725 ENOG4105C4R Atp-dependent dna helicase HCG51_RS29825 ENOG4105EW6 flavin reductase domain protein, FMN-binding HCG51_RS29830 ENOG4107T8T UPF0173 metal-dependent hydrolase HCG51_RS29840 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HCG51_RS29845 ENOG4106WTF Glycosyl transferase, family 2 HCG51_RS29855 ENOG4105CKK Glycosyl transferase, family 2 HCG51_RS29860 ENOG4107STW synthase HCG51_RS29875 ENOG4105CPK Glycosyl transferase (Group 1 HCG51_RS29880 ENOG4105CAQ asparagine synthetase HCG51_RS29885 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HCG51_RS29905 ENOG4105CPK Glycosyl transferase (Group 1 HCG51_RS29915 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HCG51_RS29925 ENOG4105CPK Glycosyl transferase (Group 1 HCG51_RS29935 ENOG4105CPK Glycosyl transferase (Group 1 HCG51_RS29955 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HCG51_RS29960 ENOG4105C1B dTDP-glucose 4-6-dehydratase HCG51_RS29980 ENOG4105D9R oxidoreductase HCG51_RS29990 ENOG4105J5G Transferase hexapeptide repeat containing protein HCG51_RS30025 ENOG4107YJ4 chain length determinant protein HCG51_RS30180 ENOG4105BZU Histidine kinase HCG51_RS30245 ENOG41068WN HCG51_RS30255 ENOG4105E0K tonB-dependent siderophore receptor HCG51_RS30290 ENOG4105DPX Hydrogenase, large subunit HCG51_RS30330 ENOG4108KGH TRANSCRIPTIONal HCG51_RS30335 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HCG51_RS30355 ENOG4105CSR polyphosphate kinase 2 HCG51_RS30415 ENOG4108USA electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon- concentration (By similarity) HCG51_RS30425 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HCG51_RS30430 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HCG51_RS30435 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HCG51_RS30450 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HCG51_RS30470 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HCG51_RS30475 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HCG51_RS30480 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HCG51_RS30485 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HCG51_RS30510 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HCG51_RS30515 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HCG51_RS30520 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HCG51_RS30550 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HCG51_RS30560 ENOG4108UJD 30S ribosomal protein S9 HCG51_RS30585 ENOG4105C5H ABC transporter HCG51_RS30590 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HCG51_RS30620 ENOG4105CPK Glycosyl transferase (Group 1 HCG51_RS30675 ENOG4106CD9 glycosyl transferase group 1 HCG51_RS30680 ENOG4105CDA abc transporter atp-binding protein HCG51_RS30685 ENOG4105DRP amino acid AbC transporter HCG51_RS30690 ENOG4105EZ7 amino acid ABC transporter HCG51_RS30695 ENOG4107QXX ABC transporter HCG51_RS30710 ENOG4107WPW Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HCG51_RS30780 ENOG4108V3E phosphoribosylglycinamide formyltransferase HCG51_RS30840 ENOG4107SBE Glycosyl transferase (Group 1 HCG51_RS30850 ENOG4105K64 Glycosyl transferase, family 2 HCG51_RS30855 ENOG4107T8Q Glycosyl transferase (Group 1 HCG51_RS30860 ENOG4105E2K Glycosyl transferase (Group 1 HCG51_RS30870 ENOG4107QJE Chromosome Partitioning Protein HCG51_RS30875 ENOG4107QJE Chromosome Partitioning Protein HCG51_RS30880 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HCG51_RS30890 ENOG4105C31 Tryptophanyl-tRNA synthetase HCG51_RS30965 ENOG4105BZU Histidine kinase HCG51_RS30980 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HCG51_RS31005 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HCG51_RS31045 ENOG410902K Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HCG51_RS31060 ENOG4105CK2 sodium dicarboxylate symporter HCG51_RS31070 ENOG4105CVK Glutamate decarboxylase HCG51_RS31085 ENOG4107JEE Short-chain dehydrogenase reductase Sdr HCG51_RS31100 ENOG4105YVS arsR family transcriptional regulator HCG51_RS31105 ENOG4105K63 Thioredoxin HCG51_RS31120 ENOG4105CYM Glutathione S-transferase HCG51_RS31145 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HCG51_RS31150 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HCG51_RS31155 ENOG4105E3N F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HCG51_RS31160 ENOG4105VYJ F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HCG51_RS31165 ENOG4105S30 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HCG51_RS31170 ENOG4105VH4 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HCG51_RS31175 ENOG4107SM1 it plays a direct role in the translocation of protons across the membrane (By similarity) HCG51_RS31180 ENOG4105PA3 atp synthase HCG51_RS31190 ENOG4107SWE Methyltransferase HCG51_RS31215 ENOG4107QPH glycogen) synthase HCG51_RS31220 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HCG51_RS31310 ENOG4105D49 3-dehydroquinate synthase HCG51_RS31340 ENOG4105D4Y metalloprotease HCG51_RS31360 ENOG4105C26 Dehydrogenase HCG51_RS31410 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HCG51_RS31415 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) HCG51_RS31420 ENOG4108NH8 Cation transport protein HCG51_RS31455 ENOG4105DC1 bifunctional purine biosynthesis protein purh HCG51_RS31505 ENOG4108HMN Caspase domain HCG51_RS31530 ENOG4105CNF WD-40 repeat protein HCG51_RS31530 ENOG4105CNF WD-40 repeat protein HCG51_RS31570 ENOG4105DR5 peptidase HCG51_RS31580 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) HCG51_RS31590 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HCG51_RS31600 ENOG4108302 MgtC SapB transporter HCG51_RS31615 ENOG4105F8J Adenylate Guanylate cyclase HCG51_RS31625 ENOG4105EWK phytoene HCG51_RS31710 ENOG4108JJA ABC, transporter HCG51_RS31790 ENOG4107WDG serine threonine protein kinase HCG51_RS31835 ENOG4105Q84 sucrose synthase HCG51_RS31840 ENOG4108N5B 2-phosphosulfolactate phosphatase HCG51_RS31900 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HCG51_RS31910 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HCG51_RS31925 ENOG4105JNK Glycosyl transferase (Group 1 HCG51_RS31995 ENOG4105WN5 stage II sporulation protein HCG51_RS32005 ENOG4105BZU Histidine kinase HCG51_RS32025 ENOG4105C8H hydrogenase maturation protein Hypf HCG51_RS32030 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HCG51_RS32035 ENOG4105CQS hydrogenase expression formation protein HypD HCG51_RS32050 ENOG4105C45 hydrogenase expression formation protein (HypE) HCG51_RS32055 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HCG51_RS32060 ENOG4107RSS Hydrogenase accessory protein HypB HCG51_RS32080 ENOG4105EWK phytoene HCG51_RS32085 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HCG51_RS32110 ENOG4105BZU Histidine kinase HCG51_RS32115 ENOG4106JD1 PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 (By similarity) HCG51_RS32205 ENOG4105BZU Histidine kinase HCG51_RS32235 ENOG4105BZU Histidine kinase HCG51_RS32240 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HCG51_RS32265 ENOG4105C26 Dehydrogenase HCG51_RS32285 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HCG51_RS32300 ENOG4105C59 p-type ATPase HCG51_RS32305 ENOG41081F0 Precorrin-8x methylmutase HCG51_RS32310 ENOG4105EU0 Major facilitator Superfamily HCG51_RS32315 ENOG4105D8V Glucose sorbosone dehydrogenase HCG51_RS32330 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HCG51_RS32345 ENOG4105CPC Aldo Keto reductase HCG51_RS32355 ENOG4105C8S subunit m HCG51_RS32365 ENOG4105JZI cytochrome P450 HCG51_RS32370 ENOG4107QRI Phosphoketolase HCG51_RS32445 ENOG4105CV1 Transketolase (EC 2.2.1.1) HCG51_RS32455 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HCG51_RS32460 ENOG41086B8 CoB-CoM heterodisulfide reductase HCG51_RS32475 ENOG41090A1 ferritin HCG51_RS32485 ENOG4105BZU Histidine kinase HCG51_RS32490 ENOG4105BZU Histidine kinase HCG51_RS32520 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HCG51_RS32525 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HCG51_RS32530 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HCG51_RS32535 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HCG51_RS32540 ENOG4107Z6A sulfate abc transporter permease HCG51_RS32555 ENOG4105JFG SpoIID LytB domain protein HCG51_RS32590 ENOG4105BZU Histidine kinase HCG51_RS32615 ENOG410848W 30S ribosomal protein S21 HCG51_RS32620 ENOG4105VFU Rna-binding protein HCG51_RS32625 ENOG4105EIE fructose-bisphosphate aldolase HCG51_RS32630 ENOG4108HMN Caspase domain HCG51_RS32655 ENOG41066AK Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) (By similarity) HCG51_RS32660 ENOG4105EWN Heme oxygenase HCG51_RS32670 ENOG4105C9M aspartyl-trna synthetase HCG51_RS32685 ENOG4105DMW Dehydrogenase reductase HCG51_RS32690 ENOG4105D2H Uronic isomerase HCG51_RS32700 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HCG51_RS32770 ENOG4105E0A ABC, transporter HCG51_RS32775 ENOG4105EHG Permease protein HCG51_RS32790 ENOG4105CNN ABC, transporter HCG51_RS32800 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HCG51_RS32805 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HCG51_RS32865 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HCG51_RS32890 ENOG4105UEI Transcriptional Regulator AraC Family HCG51_RS32895 ENOG4105CPC Aldo Keto reductase HCG51_RS32900 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HCG51_RS32935 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HCG51_RS32955 ENOG4108YBA Histidine kinase HCG51_RS32985 ENOG4105D7T ABC transporter HCG51_RS33000 ENOG4105BZU Histidine kinase HCG51_RS33010 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HCG51_RS33040 ENOG4105HFZ Membrane HCG51_RS33050 ENOG4105CEY Amp-dependent synthetase and ligase HCG51_RS33055 ENOG4108JZP Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate (By similarity) HCG51_RS33115 ENOG4105C42 Type I secretion membrane fusion protein (HlyD HCG51_RS33120 ENOG4108JJA ABC, transporter HCG51_RS33130 ENOG4105K4I Scp-like extracellular HCG51_RS33175 ENOG4107WDG serine threonine protein kinase HCG51_RS33190 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HCG51_RS33195 ENOG41082AN stage II sporulation protein HCG51_RS33225 ENOG4105EPC oxidoreductase HCG51_RS33310 ENOG4107YXA Transcriptional regulator, BadM Rrf2 family HCG51_RS33315 ENOG4105D7W serine acetyltransferase HCG51_RS33325 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HCG51_RS33330 ENOG4105BZU Histidine kinase HCG51_RS33340 ENOG4105DBV ornithine carbamoyltransferase HCG51_RS33350 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HCG51_RS33410 ENOG4105BZU Histidine kinase HCG51_RS33420 ENOG4108IAJ Nad-dependent epimerase dehydratase HCG51_RS33425 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HCG51_RS33430 ENOG4105CMV Succinyl-CoA synthetase subunit beta HCG51_RS33465 ENOG41067HS methyltransferase HCG51_RS33490 ENOG4105HNP -acetyltransferase HCG51_RS33505 ENOG4105EYM Major Facilitator superfamily HCG51_RS33520 ENOG4105EYH Exonuclease HCG51_RS33535 ENOG4108W3Y Transcriptional regulator, Crp Fnr family HCG51_RS33570 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HCG51_RS33620 ENOG4105CJ1 ABC, transporter HCG51_RS33635 ENOG4105Y3U Transglycosylase-associated protein HCG51_RS33645 ENOG4105H0Z Hemerythrin HHE cation binding domain protein HCG51_RS33655 ENOG4105CFP Peptidase U32 HCG51_RS33675 ENOG4105BZU Histidine kinase HCG51_RS33695 ENOG4108VIA integral membrane protein HCG51_RS33705 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HCG51_RS33740 ENOG4105C5H ABC transporter HCG51_RS33760 ENOG4105BZ1 (ABC) transporter HCG51_RS33775 ENOG4105JZI cytochrome P450 HCG51_RS33780 ENOG4107SKI cobyrinic Acid a,c-diamide synthase HCG51_RS33800 ENOG4105ETX regulatoR HCG51_RS33805 ENOG4105BZU Histidine kinase HCG51_RS33820 ENOG4105BZU Histidine kinase HCG51_RS33825 ENOG4105BZU Histidine kinase HCG51_RS33835 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HCG51_RS33860 ENOG4107WDG serine threonine protein kinase HCG51_RS33965 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HCG51_RS33980 ENOG4105FA0 parb-like partition protein HCG51_RS33985 ENOG4107QJE Chromosome Partitioning Protein HCG51_RS34175 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HCG51_RS34240 ENOG4105CVP deoxyribo-dipyrimidine photolyase HCG51_RS34285 ENOG4105EUB pirin domain protein HCG51_RS34290 ENOG4105CPC Aldo Keto reductase HCG51_RS34295 ENOG4108FN7 Aldo keto reductase HCG51_RS34325 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HCG51_RS34415 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F HCG51_RS34475 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A HCG51_RS34605 ENOG4105EKQ RNA-directed DNA polymerase HCG51_RS34625 ENOG4105BZU Histidine kinase HCG51_RS34635 ENOG4105C59 p-type ATPase HCG51_RS34840 ENOG4107QJE Chromosome Partitioning Protein HCG51_RS34845 ENOG4105FA0 parb-like partition protein HCG51_RS34870 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HCG51_RS34880 ENOG4105C42 Type I secretion membrane fusion protein (HlyD HCG51_RS35040 ENOG4107QJE Chromosome Partitioning Protein HCG51_RS35120 ENOG4105WH9 RNA polymerase HCG51_RS35195 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HCG51_RS35200 ENOG4105K4I Scp-like extracellular HCG51_RS35210 ENOG4107SKI cobyrinic Acid a,c-diamide synthase HCG51_RS35285 ENOG4107QJE Chromosome Partitioning Protein HCG51_RS35290 ENOG4105FA0 parb-like partition protein