locus-tag	class	description
HCG51_RS00005	COG5002	protein histidine kinase activity
HCG51_RS00005	COG3850	Histidine kinase
HCG51_RS00010	COG0784	Response regulator, receiver
HCG51_RS00015	COG4251	negative regulation of phosphorylation
HCG51_RS00040	COG0484	heat shock protein binding
HCG51_RS00055	COG1122	ATPase activity
HCG51_RS00065	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
HCG51_RS00070	COG0310	cobalt ion transport
HCG51_RS00090	COG0587	DNA-directed DNA polymerase activity
HCG51_RS00095	COG0154	amidase activity
HCG51_RS00100	COG2945	thiolester hydrolase activity
HCG51_RS00115	COG0436	Aminotransferase
HCG51_RS00120	COG0371	Dehydrogenase
HCG51_RS00135	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HCG51_RS00140	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HCG51_RS00170	COG4221	oxidoreductase activity
HCG51_RS00175	COG3903	Transcriptional regulator
HCG51_RS00175	COG2319	Wd-40 repeat
HCG51_RS00200	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HCG51_RS00240	COG2076	Multidrug Resistance protein
HCG51_RS00260	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HCG51_RS00265	COG2201	protein-glutamate methylesterase activity
HCG51_RS00280	COG0840	transmembrane signaling receptor activity
HCG51_RS00280	COG2203	Gaf domain
HCG51_RS00285	COG0784	Response regulator, receiver
HCG51_RS00285	COG0643	Histidine kinase
HCG51_RS00285	COG2198	Histidine kinase
HCG51_RS00290	COG4251	negative regulation of phosphorylation
HCG51_RS00290	COG5001	Diguanylate cyclase
HCG51_RS00290	COG2203	Gaf domain
HCG51_RS00290	COG3706	GGDEF domain
HCG51_RS00295	COG1176	ABC-type spermidine putrescine transport system, permease component I
HCG51_RS00310	COG3842	ATPase activity
HCG51_RS00315	COG0768	penicillin binding
HCG51_RS00320	COG0768	penicillin binding
HCG51_RS00325	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HCG51_RS00330	COG0587	DNA-directed DNA polymerase activity
HCG51_RS00395	COG1131	(ABC) transporter
HCG51_RS00420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCG51_RS00425	COG1846	Transcriptional regulator
HCG51_RS00435	COG0515	serine threonine protein kinase
HCG51_RS00435	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_RS00445	COG1177	transmembrane transport
HCG51_RS00450	COG0438	transferase activity, transferring glycosyl groups
HCG51_RS00460	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HCG51_RS00495	COG0095	Lipoate-protein ligase
HCG51_RS00505	COG1649	PFAM Uncharacterised BCR, COG1649
HCG51_RS00510	COG0737	Belongs to the 5'-nucleotidase family
HCG51_RS00540	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HCG51_RS00545	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HCG51_RS00545	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HCG51_RS00550	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HCG51_RS00555	COG2066	Belongs to the glutaminase family
HCG51_RS00570	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HCG51_RS00580	COG0673	inositol 2-dehydrogenase activity
HCG51_RS00585	COG1881	PFAM PEBP family protein
HCG51_RS00595	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HCG51_RS00605	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HCG51_RS00625	COG4106	trans-aconitate 2-methyltransferase activity
HCG51_RS00635	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HCG51_RS00640	COG0667	Aldo Keto reductase
HCG51_RS00675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCG51_RS00685	COG0535	radical SAM domain protein
HCG51_RS00745	COG1446	asparaginase
HCG51_RS00750	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HCG51_RS00760	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HCG51_RS00805	COG0778	Nitroreductase
HCG51_RS00815	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HCG51_RS00845	COG5001	Diguanylate cyclase
HCG51_RS00850	COG2217	Heavy metal translocating P-type atpase
HCG51_RS00880	COG0121	glutamine amidotransferase
HCG51_RS00885	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HCG51_RS00890	COG1959	2 iron, 2 sulfur cluster binding
HCG51_RS00935	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HCG51_RS00950	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HCG51_RS00965	COG0724	RNA recognition motif
HCG51_RS00970	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HCG51_RS00990	COG1252	NADH dehydrogenase
HCG51_RS00995	COG2205	protein histidine kinase activity
HCG51_RS01005	COG0277	FAD linked oxidase domain protein
HCG51_RS01010	COG0247	lactate metabolic process
HCG51_RS01020	COG2211	Major facilitator Superfamily
HCG51_RS01025	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HCG51_RS01080	COG2911	Protein conserved in bacteria
HCG51_RS01080	COG3266	domain, Protein
HCG51_RS01080	COG1361	Conserved repeat domain
HCG51_RS01090	COG0583	DNA-binding transcription factor activity
HCG51_RS01200	COG0811	peptide transport
HCG51_RS01205	COG0848	biopolymer transport protein
HCG51_RS01210	COG0628	permease
HCG51_RS01230	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HCG51_RS01240	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HCG51_RS01260	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HCG51_RS01330	COG2197	response regulator
HCG51_RS01360	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HCG51_RS01360	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HCG51_RS01360	COG1013	pyruvate-flavodoxin oxidoreductase activity
HCG51_RS01360	COG0674	pyruvate-flavodoxin oxidoreductase activity
HCG51_RS01370	COG0339	signal peptide processing
HCG51_RS01380	COG1309	transcriptional regulator
HCG51_RS01385	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HCG51_RS01390	COG2205	protein histidine kinase activity
HCG51_RS01390	COG5002	protein histidine kinase activity
HCG51_RS01390	COG0784	Response regulator, receiver
HCG51_RS01415	COG0784	Response regulator, receiver
HCG51_RS01415	COG5002	protein histidine kinase activity
HCG51_RS01420	COG0731	radical SAM domain protein
HCG51_RS01445	COG3266	domain, Protein
HCG51_RS01445	COG0515	serine threonine protein kinase
HCG51_RS01450	COG0515	serine threonine protein kinase
HCG51_RS01460	COG5002	protein histidine kinase activity
HCG51_RS01465	COG0745	RESPONSE REGULATOR receiver
HCG51_RS01495	COG3386	PFAM SMP-30 Gluconolaconase
HCG51_RS01505	COG0628	permease
HCG51_RS01520	COG1028	Short-chain dehydrogenase reductase Sdr
HCG51_RS01525	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HCG51_RS01525	COG3408	Glycogen debranching enzyme
HCG51_RS01550	COG0501	Belongs to the peptidase M48B family
HCG51_RS01555	COG0071	Belongs to the small heat shock protein (HSP20) family
HCG51_RS01565	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_RS01565	COG0515	serine threonine protein kinase
HCG51_RS01570	COG0515	serine threonine protein kinase
HCG51_RS01570	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_RS01580	COG1011	Hydrolase
HCG51_RS01600	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HCG51_RS01605	COG1175	transmembrane transport
HCG51_RS01615	COG0745	RESPONSE REGULATOR receiver
HCG51_RS01620	COG2183	response to ionizing radiation
HCG51_RS01630	COG1950	PFAM Membrane protein of
HCG51_RS01650	COG2010	Cytochrome c
HCG51_RS01660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HCG51_RS01665	COG0745	RESPONSE REGULATOR receiver
HCG51_RS01670	COG0697	spore germination
HCG51_RS01685	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HCG51_RS01695	COG0501	Belongs to the peptidase M48B family
HCG51_RS01700	COG1704	LemA family
HCG51_RS01705	COG0778	Nitroreductase
HCG51_RS01720	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HCG51_RS01740	COG2205	protein histidine kinase activity
HCG51_RS01745	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCG51_RS01770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HCG51_RS01775	COG0581	inorganic phosphate transmembrane transporter activity
HCG51_RS01790	COG0640	Transcriptional regulator
HCG51_RS01830	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HCG51_RS01885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCG51_RS01895	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_RS01895	COG0515	serine threonine protein kinase
HCG51_RS01915	COG2885	chlorophyll binding
HCG51_RS01920	COG4932	domain protein
HCG51_RS01930	COG0515	serine threonine protein kinase
HCG51_RS01930	COG3266	domain, Protein
HCG51_RS01940	COG0123	including yeast histone deacetylase and acetoin utilization protein
HCG51_RS01990	COG1063	alcohol dehydrogenase
HCG51_RS02035	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HCG51_RS02050	COG0386	Belongs to the glutathione peroxidase family
HCG51_RS02060	COG1252	NADH dehydrogenase
HCG51_RS02070	COG1845	cytochrome c oxidase, subunit III
HCG51_RS02075	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HCG51_RS02080	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HCG51_RS02100	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HCG51_RS02100	COG0678	peroxiredoxin activity
HCG51_RS02105	COG4251	negative regulation of phosphorylation
HCG51_RS02110	COG0784	Response regulator, receiver
HCG51_RS02120	COG2205	protein histidine kinase activity
HCG51_RS02140	COG1309	transcriptional regulator
HCG51_RS02155	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCG51_RS02220	COG5398	heme oxygenase
HCG51_RS02225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HCG51_RS02245	COG0438	transferase activity, transferring glycosyl groups
HCG51_RS02250	COG0438	transferase activity, transferring glycosyl groups
HCG51_RS02255	COG0450	alkyl hydroperoxide reductase
HCG51_RS02265	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HCG51_RS02270	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HCG51_RS02325	COG1366	Belongs to the anti-sigma-factor antagonist family
HCG51_RS02330	COG1366	Belongs to the anti-sigma-factor antagonist family
HCG51_RS02340	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HCG51_RS02340	COG0392	lysyltransferase activity
HCG51_RS02350	COG2076	Multidrug Resistance protein
HCG51_RS02355	COG0723	plastoquinol--plastocyanin reductase activity
HCG51_RS02360	COG1309	transcriptional regulator
HCG51_RS02365	COG2239	Acts as a magnesium transporter
HCG51_RS02370	COG2133	pyrroloquinoline quinone binding
HCG51_RS02385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCG51_RS02390	COG0398	Pfam SNARE associated Golgi protein
HCG51_RS02400	COG0398	Pfam SNARE associated Golgi protein
HCG51_RS02425	COG4636	protein conserved in cyanobacteria
HCG51_RS02450	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HCG51_RS02455	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HCG51_RS02470	COG0473	3-isopropylmalate dehydrogenase activity
HCG51_RS02475	COG0668	transmembrane transport
HCG51_RS02485	COG3335	DDE superfamily endonuclease
HCG51_RS02510	COG0517	IMP dehydrogenase activity
HCG51_RS02510	COG1125	glycine betaine transport
HCG51_RS02550	COG3706	GGDEF domain
HCG51_RS02550	COG5001	Diguanylate cyclase
HCG51_RS02550	COG4251	negative regulation of phosphorylation
HCG51_RS02550	COG2203	Gaf domain
HCG51_RS02570	COG0784	Response regulator, receiver
HCG51_RS02590	COG0564	pseudouridine synthase activity
HCG51_RS02595	COG3118	belongs to the thioredoxin family
HCG51_RS02600	COG2264	protein methyltransferase activity
HCG51_RS02605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HCG51_RS02610	COG0515	serine threonine protein kinase
HCG51_RS02610	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_RS02655	COG1487	ribonuclease activity
HCG51_RS02685	COG0432	Pfam Uncharacterised protein family UPF0047
HCG51_RS02690	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HCG51_RS02705	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HCG51_RS02725	COG0582	viral genome integration into host DNA
HCG51_RS02755	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HCG51_RS02760	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HCG51_RS02770	COG0318	PFAM AMP-dependent synthetase and ligase
HCG51_RS02775	COG1289	transmembrane transporter activity
HCG51_RS02785	COG0748	coenzyme F420 binding
HCG51_RS02800	COG0668	transmembrane transport
HCG51_RS02860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCG51_RS02865	COG2226	methyltransferase
HCG51_RS02900	COG0222	ribosome binding
HCG51_RS02955	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HCG51_RS02960	COG0667	Aldo Keto reductase
HCG51_RS02965	COG3659	wide pore channel activity
HCG51_RS02970	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCG51_RS03010	COG0778	Nitroreductase
HCG51_RS03020	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCG51_RS03025	COG2175	clavaminate synthase activity
HCG51_RS03030	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HCG51_RS03035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCG51_RS03040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCG51_RS03045	COG0431	NADPH-dependent FMN reductase
HCG51_RS03055	COG0745	RESPONSE REGULATOR receiver
HCG51_RS03070	COG1324	tolerance protein
HCG51_RS03085	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HCG51_RS03095	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HCG51_RS03115	COG0589	response to stress
HCG51_RS03120	COG2217	Heavy metal translocating P-type atpase
HCG51_RS03130	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HCG51_RS03135	COG2217	Heavy metal translocating P-type atpase
HCG51_RS03140	COG1475	DNA binding
HCG51_RS03180	COG0288	reversible hydration of carbon dioxide
HCG51_RS03195	COG2832	Protein of unknown function (DUF454)
HCG51_RS03205	COG0387	Pfam Sodium calcium exchanger
HCG51_RS03220	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HCG51_RS03230	COG2319	Wd-40 repeat
HCG51_RS03230	COG4249	Peptidase C14 caspase catalytic subunit p20
HCG51_RS03255	COG2319	Wd-40 repeat
HCG51_RS03290	COG2319	Wd-40 repeat
HCG51_RS03290	COG1672	PFAM Archaeal ATPase
HCG51_RS03300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCG51_RS03315	COG0330	HflC and HflK could
HCG51_RS03325	COG0730	response to heat
HCG51_RS03340	COG1181	Belongs to the D-alanine--D-alanine ligase family
HCG51_RS03355	COG0288	reversible hydration of carbon dioxide
HCG51_RS03365	COG0667	Aldo Keto reductase
HCG51_RS03385	COG2954	triphosphatase activity
HCG51_RS03390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCG51_RS03410	COG1914	H( )-stimulated, divalent metal cation uptake system
HCG51_RS03430	COG2205	protein histidine kinase activity
HCG51_RS03430	COG0784	Response regulator, receiver
HCG51_RS03445	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HCG51_RS03450	COG0667	Aldo Keto reductase
HCG51_RS03465	COG1956	GAF domain-containing protein
HCG51_RS03485	COG1464	Belongs to the NlpA lipoprotein family
HCG51_RS03505	COG0625	glutathione transferase activity
HCG51_RS03515	COG2252	PERMEase
HCG51_RS03525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCG51_RS03540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCG51_RS03560	COG0412	Dienelactone hydrolase
HCG51_RS03565	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCG51_RS03575	COG0561	phosphatase activity
HCG51_RS03595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HCG51_RS03640	COG2873	o-acetylhomoserine
HCG51_RS03645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HCG51_RS03655	COG2011	ABC-type metal ion transport system permease component
HCG51_RS03665	COG1464	Belongs to the NlpA lipoprotein family
HCG51_RS03680	COG1116	anion transmembrane transporter activity
HCG51_RS03695	COG4221	oxidoreductase activity
HCG51_RS03700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCG51_RS03705	COG2814	Major facilitator Superfamily
HCG51_RS03720	COG0346	lactoylglutathione lyase activity
HCG51_RS03725	COG3453	Protein conserved in bacteria
HCG51_RS03725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCG51_RS03745	COG4106	trans-aconitate 2-methyltransferase activity
HCG51_RS03750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCG51_RS03765	COG2226	methyltransferase
HCG51_RS03775	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HCG51_RS03795	COG4106	trans-aconitate 2-methyltransferase activity
HCG51_RS03825	COG0697	spore germination
HCG51_RS03830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCG51_RS03835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCG51_RS03845	COG1028	Short-chain dehydrogenase reductase Sdr
HCG51_RS03865	COG0604	alcohol dehydrogenase
HCG51_RS03880	COG1247	-acetyltransferase
HCG51_RS03885	COG2897	thiosulfate sulfurtransferase activity
HCG51_RS03895	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCG51_RS03895	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCG51_RS03905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCG51_RS03915	COG2072	flavoprotein involved in K transport
HCG51_RS03925	COG0667	Aldo Keto reductase
HCG51_RS03930	COG1132	(ABC) transporter
HCG51_RS03935	COG4122	O-methyltransferase activity
HCG51_RS03940	COG0723	plastoquinol--plastocyanin reductase activity
HCG51_RS03945	COG0625	glutathione transferase activity
HCG51_RS03975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCG51_RS03980	COG0456	acetyltransferase
HCG51_RS03985	COG1324	tolerance protein
HCG51_RS03990	COG2814	Major facilitator Superfamily
HCG51_RS03995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCG51_RS04000	COG2175	clavaminate synthase activity
HCG51_RS04005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HCG51_RS04015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCG51_RS04020	COG0601	transmembrane transport
HCG51_RS04030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCG51_RS04060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCG51_RS04070	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HCG51_RS04075	COG0459	protein refolding
HCG51_RS04100	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HCG51_RS04115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCG51_RS04120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCG51_RS04130	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HCG51_RS04140	COG0573	inorganic phosphate transmembrane transporter activity
HCG51_RS04145	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HCG51_RS04150	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HCG51_RS04175	COG3659	wide pore channel activity
HCG51_RS04180	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HCG51_RS04185	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HCG51_RS04190	COG3639	organic phosphonate transmembrane transporter activity
HCG51_RS04205	COG3624	Phosphonate C-P lyase system protein PhnG
HCG51_RS04210	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HCG51_RS04220	COG3626	phosphonate metabolism
HCG51_RS04225	COG3454	Phosphonate metabolism
HCG51_RS04235	COG3627	carbon phosphorus lyase activity
HCG51_RS04240	COG4107	phosphonate C-P lyase system protein PhnK
HCG51_RS04245	COG4778	phosphonate C-P lyase system protein PhnL
HCG51_RS04250	COG3454	Phosphonate metabolism
HCG51_RS04255	COG0318	PFAM AMP-dependent synthetase and ligase
HCG51_RS04270	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HCG51_RS04320	COG2205	protein histidine kinase activity
HCG51_RS04320	COG0784	Response regulator, receiver
HCG51_RS04325	COG1943	Transposase
HCG51_RS04345	COG5002	protein histidine kinase activity
HCG51_RS04360	COG0318	PFAM AMP-dependent synthetase and ligase
HCG51_RS04375	COG3321	synthase
HCG51_RS04375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCG51_RS04375	COG4221	oxidoreductase activity
HCG51_RS04375	COG0300	oxidoreductase activity
HCG51_RS04380	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HCG51_RS04410	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HCG51_RS04415	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCG51_RS04430	COG2988	succinylglutamate desuccinylase activity
HCG51_RS04435	COG0583	DNA-binding transcription factor activity
HCG51_RS04465	COG4249	Peptidase C14 caspase catalytic subunit p20
HCG51_RS04465	COG2319	Wd-40 repeat
HCG51_RS04470	COG2252	PERMEase
HCG51_RS04475	COG1404	Belongs to the peptidase S8 family
HCG51_RS04510	COG0071	Belongs to the small heat shock protein (HSP20) family
HCG51_RS04540	COG4566	intracellular signal transduction
HCG51_RS04545	COG2205	protein histidine kinase activity
HCG51_RS04555	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HCG51_RS04580	COG0515	serine threonine protein kinase
HCG51_RS04580	COG2815	serine threonine protein kinase
HCG51_RS04600	COG2203	Gaf domain
HCG51_RS04600	COG0840	transmembrane signaling receptor activity
HCG51_RS04605	COG0784	Response regulator, receiver
HCG51_RS04640	COG0515	serine threonine protein kinase
HCG51_RS04645	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCG51_RS04650	COG1121	(ABC) transporter
HCG51_RS04685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCG51_RS04695	COG3320	Male sterility
HCG51_RS04695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCG51_RS04700	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HCG51_RS04700	COG2070	2-Nitropropane dioxygenase
HCG51_RS04705	COG4221	oxidoreductase activity
HCG51_RS04705	COG3321	synthase
HCG51_RS04705	COG0300	oxidoreductase activity
HCG51_RS04705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCG51_RS04715	COG3321	synthase
HCG51_RS04715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCG51_RS04715	COG4221	oxidoreductase activity
HCG51_RS04715	COG1028	Short-chain dehydrogenase reductase Sdr
HCG51_RS04720	COG0604	alcohol dehydrogenase
HCG51_RS04720	COG3321	synthase
HCG51_RS04755	COG1475	DNA binding
HCG51_RS04765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCG51_RS04780	COG1215	transferase activity, transferring glycosyl groups
HCG51_RS04810	COG0300	oxidoreductase activity
HCG51_RS04820	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HCG51_RS04825	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HCG51_RS04840	COG0745	RESPONSE REGULATOR receiver
HCG51_RS04850	COG0110	maltose O-acetyltransferase activity
HCG51_RS04870	COG3903	Transcriptional regulator
HCG51_RS04870	COG3629	intracellular signal transduction
HCG51_RS04890	COG0038	chloride channel
HCG51_RS04900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCG51_RS04915	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HCG51_RS04945	COG0671	phosphoesterase, PA-phosphatase related
HCG51_RS04950	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HCG51_RS04955	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HCG51_RS04955	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HCG51_RS04965	COG1252	NADH dehydrogenase
HCG51_RS04970	COG1543	Belongs to the glycosyl hydrolase 57 family
HCG51_RS04975	COG1162	GTPase activity
HCG51_RS04985	COG0484	heat shock protein binding
HCG51_RS04990	COG0443	Heat shock 70 kDa protein
HCG51_RS04995	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HCG51_RS05000	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HCG51_RS05010	COG1459	type II secretion system
HCG51_RS05025	COG1480	7TM receptor with intracellular HD hydrolase
HCG51_RS05040	COG3394	polysaccharide catabolic process
HCG51_RS05045	COG2815	serine threonine protein kinase
HCG51_RS05045	COG0515	serine threonine protein kinase
HCG51_RS05110	COG0151	Belongs to the GarS family
HCG51_RS05115	COG5002	protein histidine kinase activity
HCG51_RS05125	COG2346	COG2346, Truncated hemoglobins
HCG51_RS05175	COG1361	Conserved repeat domain
HCG51_RS05185	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HCG51_RS05195	COG0604	alcohol dehydrogenase
HCG51_RS05200	COG0412	Dienelactone hydrolase
HCG51_RS05245	COG0539	negative regulation of cytoplasmic translation
HCG51_RS05310	COG0747	negative chemotaxis
HCG51_RS05340	COG0784	Response regulator, receiver
HCG51_RS05340	COG2205	protein histidine kinase activity
HCG51_RS05350	COG2884	Cell division ATP-binding protein ftsE
HCG51_RS05360	COG2197	response regulator
HCG51_RS05380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HCG51_RS05380	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HCG51_RS05390	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HCG51_RS05405	COG1316	TRANSCRIPTIONal
HCG51_RS05415	COG0628	permease
HCG51_RS05430	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HCG51_RS05470	COG3237	CsbD-like
HCG51_RS05480	COG0556	nucleotide-excision repair
HCG51_RS05535	COG3585	molybdate ion transport
HCG51_RS05550	COG0316	Belongs to the HesB IscA family
HCG51_RS05555	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HCG51_RS05565	COG5420	small protein containing a coiled-coil domain
HCG51_RS05580	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HCG51_RS05665	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HCG51_RS05675	COG0582	viral genome integration into host DNA
HCG51_RS05700	COG4191	Histidine kinase
HCG51_RS05720	COG0412	Dienelactone hydrolase
HCG51_RS05740	COG1733	regulation of RNA biosynthetic process
HCG51_RS05745	COG1902	pentaerythritol trinitrate reductase activity
HCG51_RS05770	COG1028	Short-chain dehydrogenase reductase Sdr
HCG51_RS05800	COG2906	2 iron, 2 sulfur cluster binding
HCG51_RS05800	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HCG51_RS05800	COG0822	iron-sulfur transferase activity
HCG51_RS05815	COG0583	DNA-binding transcription factor activity
HCG51_RS05835	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HCG51_RS05840	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HCG51_RS05845	COG3781	membrane
HCG51_RS05850	COG3781	membrane
HCG51_RS05865	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HCG51_RS05890	COG4636	protein conserved in cyanobacteria
HCG51_RS05915	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HCG51_RS05945	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HCG51_RS05990	COG1487	ribonuclease activity
HCG51_RS06015	COG1045	serine acetyltransferase
HCG51_RS06030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HCG51_RS06035	COG5554	nitrogen fixation
HCG51_RS06040	COG5554	nitrogen fixation
HCG51_RS06065	COG0442	prolyl-tRNA aminoacylation
HCG51_RS06075	COG0640	Transcriptional regulator
HCG51_RS06080	COG0511	ligase activity, forming carbon-carbon bonds
HCG51_RS06085	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HCG51_RS06090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HCG51_RS06100	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HCG51_RS06105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HCG51_RS06110	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HCG51_RS06115	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HCG51_RS06120	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HCG51_RS06125	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HCG51_RS06130	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HCG51_RS06135	COG0745	RESPONSE REGULATOR receiver
HCG51_RS06140	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HCG51_RS06155	COG2205	protein histidine kinase activity
HCG51_RS06155	COG2198	Histidine kinase
HCG51_RS06155	COG0784	Response regulator, receiver
HCG51_RS06175	COG1596	polysaccharide export
HCG51_RS06180	COG0489	protein tyrosine kinase activity
HCG51_RS06180	COG3206	protein involved in exopolysaccharide biosynthesis
HCG51_RS06195	COG0745	RESPONSE REGULATOR receiver
HCG51_RS06200	COG5002	protein histidine kinase activity
HCG51_RS06350	COG2226	methyltransferase
HCG51_RS06360	COG2909	trisaccharide binding
HCG51_RS06385	COG5002	protein histidine kinase activity
HCG51_RS06385	COG5000	phosphorelay sensor kinase activity
HCG51_RS06390	COG0745	RESPONSE REGULATOR receiver
HCG51_RS06420	COG3386	PFAM SMP-30 Gluconolaconase
HCG51_RS06425	COG4178	(ABC) transporter
HCG51_RS06480	COG3335	DDE superfamily endonuclease
HCG51_RS06550	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HCG51_RS06555	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HCG51_RS06560	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HCG51_RS06565	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HCG51_RS06570	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HCG51_RS06575	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HCG51_RS06590	COG1702	phosphate starvation-inducible protein PhoH
HCG51_RS06595	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HCG51_RS06605	COG0228	four-way junction DNA binding
HCG51_RS06610	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HCG51_RS06620	COG0006	proline dipeptidase activity
HCG51_RS06630	COG0784	Response regulator, receiver
HCG51_RS06630	COG5002	protein histidine kinase activity
HCG51_RS06635	COG0384	phenazine biosynthesis protein PhzF
HCG51_RS06655	COG0612	Peptidase, M16
HCG51_RS06660	COG0612	Peptidase, M16
HCG51_RS06710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HCG51_RS06730	COG2274	protein secretion by the type I secretion system
HCG51_RS06745	COG0540	Belongs to the ATCase OTCase family
HCG51_RS06750	COG2239	Acts as a magnesium transporter
HCG51_RS06780	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HCG51_RS06790	COG0515	serine threonine protein kinase
HCG51_RS06790	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_RS06800	COG2119	membrane
HCG51_RS06815	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HCG51_RS06815	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HCG51_RS06820	COG0515	serine threonine protein kinase
HCG51_RS06820	COG2815	serine threonine protein kinase
HCG51_RS06880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCG51_RS06890	COG2003	Belongs to the UPF0758 family
HCG51_RS06895	COG0066	3-isopropylmalate dehydratase activity
HCG51_RS06900	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HCG51_RS06915	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HCG51_RS06920	COG0408	coproporphyrinogen oxidase activity
HCG51_RS06960	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HCG51_RS06960	COG0438	transferase activity, transferring glycosyl groups
HCG51_RS06965	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCG51_RS06975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCG51_RS06980	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HCG51_RS07000	COG1132	(ABC) transporter
HCG51_RS07010	COG2226	methyltransferase
HCG51_RS07015	COG0438	transferase activity, transferring glycosyl groups
HCG51_RS07025	COG1216	Glycosyl transferase, family 2
HCG51_RS07035	COG0435	Glutathione S-transferase
HCG51_RS07060	COG4251	negative regulation of phosphorylation
HCG51_RS07060	COG3706	GGDEF domain
HCG51_RS07060	COG4251	negative regulation of phosphorylation
HCG51_RS07060	COG3706	GGDEF domain
HCG51_RS07060	COG2203	Gaf domain
HCG51_RS07060	COG2203	Gaf domain
HCG51_RS07060	COG5001	Diguanylate cyclase
HCG51_RS07060	COG5001	Diguanylate cyclase
HCG51_RS07085	COG4191	Histidine kinase
HCG51_RS07110	COG0515	serine threonine protein kinase
HCG51_RS07115	COG0702	epimerase
HCG51_RS07120	COG0432	Pfam Uncharacterised protein family UPF0047
HCG51_RS07140	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HCG51_RS07215	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HCG51_RS07225	COG1254	Belongs to the acylphosphatase family
HCG51_RS07235	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HCG51_RS07240	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HCG51_RS07245	COG0189	ligase activity
HCG51_RS07245	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HCG51_RS07255	COG4242	Belongs to the peptidase S51 family
HCG51_RS07265	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HCG51_RS07275	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HCG51_RS07280	COG1695	Transcriptional regulator
HCG51_RS07335	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HCG51_RS07345	COG0406	alpha-ribazole phosphatase activity
HCG51_RS07365	COG0564	pseudouridine synthase activity
HCG51_RS07390	COG0697	spore germination
HCG51_RS07410	COG2010	Cytochrome c
HCG51_RS07445	COG2202	Pas domain
HCG51_RS07445	COG2205	protein histidine kinase activity
HCG51_RS07480	COG3744	PilT protein domain protein
HCG51_RS07505	COG0006	proline dipeptidase activity
HCG51_RS07520	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HCG51_RS07520	COG0512	Glutamine amidotransferase of anthranilate synthase
HCG51_RS07525	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HCG51_RS07530	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HCG51_RS07545	COG1657	PFAM Prenyltransferase squalene oxidase
HCG51_RS07555	COG1215	transferase activity, transferring glycosyl groups
HCG51_RS07565	COG0745	RESPONSE REGULATOR receiver
HCG51_RS07570	COG2226	methyltransferase
HCG51_RS07610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCG51_RS07675	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HCG51_RS07690	COG4783	chaperone-mediated protein folding
HCG51_RS07695	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HCG51_RS07705	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HCG51_RS07705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCG51_RS07710	COG3437	response regulator, receiver
HCG51_RS07715	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HCG51_RS07720	COG2319	Wd-40 repeat
HCG51_RS07725	COG1446	asparaginase
HCG51_RS07740	COG0167	dihydroorotate dehydrogenase activity
HCG51_RS07770	COG2304	oxidoreductase activity
HCG51_RS07780	COG2198	Histidine kinase
HCG51_RS07780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCG51_RS07780	COG2205	protein histidine kinase activity
HCG51_RS07780	COG0784	Response regulator, receiver
HCG51_RS07785	COG0477	Major facilitator Superfamily
HCG51_RS07790	COG0515	serine threonine protein kinase
HCG51_RS07790	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_RS07800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HCG51_RS07810	COG0514	ATP-dependent DNA helicase (RecQ)
HCG51_RS07815	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HCG51_RS07820	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HCG51_RS07825	COG1234	tRNA 3'-trailer cleavage
HCG51_RS07830	COG0196	riboflavin kinase activity
HCG51_RS07835	COG0714	Associated with various cellular activities
HCG51_RS07855	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HCG51_RS07910	COG5001	Diguanylate cyclase
HCG51_RS07910	COG2203	Gaf domain
HCG51_RS07910	COG3706	GGDEF domain
HCG51_RS07910	COG4251	negative regulation of phosphorylation
HCG51_RS07915	COG0531	amino acid
HCG51_RS07950	COG1012	belongs to the aldehyde dehydrogenase family
HCG51_RS07970	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HCG51_RS07975	COG0501	Belongs to the peptidase M48B family
HCG51_RS08030	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HCG51_RS08035	COG4279	zinc finger
HCG51_RS08065	COG0628	permease
HCG51_RS08095	COG0784	Response regulator, receiver
HCG51_RS08095	COG2205	protein histidine kinase activity
HCG51_RS08105	COG2119	membrane
HCG51_RS08110	COG4581	dead DEAH box helicase
HCG51_RS08115	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HCG51_RS08120	COG1799	cell septum assembly
HCG51_RS08125	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HCG51_RS08135	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HCG51_RS08140	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HCG51_RS08145	COG1160	GTP binding
HCG51_RS08160	COG1192	Involved in chromosome partitioning
HCG51_RS08180	COG3237	CsbD-like
HCG51_RS08190	COG2205	protein histidine kinase activity
HCG51_RS08190	COG0784	Response regulator, receiver
HCG51_RS08195	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HCG51_RS08210	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
HCG51_RS08225	COG1573	uracil-dna glycosylase
HCG51_RS08240	COG2205	protein histidine kinase activity
HCG51_RS08240	COG3437	response regulator, receiver
HCG51_RS08240	COG4999	Histidine kinase
HCG51_RS08240	COG3850	Histidine kinase
HCG51_RS08270	COG0157	Belongs to the NadC ModD family
HCG51_RS08275	COG0598	Magnesium transport protein CorA
HCG51_RS08285	COG1012	belongs to the aldehyde dehydrogenase family
HCG51_RS08285	COG1454	alcohol dehydrogenase
HCG51_RS08290	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HCG51_RS08295	COG1882	Formate acetyltransferase
HCG51_RS08305	COG0714	Associated with various cellular activities
HCG51_RS08315	COG1305	Transglutaminase-like
HCG51_RS08350	COG1216	Glycosyl transferase, family 2
HCG51_RS08360	COG4636	protein conserved in cyanobacteria
HCG51_RS08365	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HCG51_RS08365	COG0140	phosphoribosyl-ATP diphosphatase activity
HCG51_RS08375	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HCG51_RS08385	COG1215	transferase activity, transferring glycosyl groups
HCG51_RS08395	COG0745	RESPONSE REGULATOR receiver
HCG51_RS08410	COG1845	cytochrome c oxidase, subunit III
HCG51_RS08420	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HCG51_RS08440	COG1012	belongs to the aldehyde dehydrogenase family
HCG51_RS08450	COG0314	molybdopterin synthase activity
HCG51_RS08480	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HCG51_RS08510	COG2319	Wd-40 repeat
HCG51_RS08510	COG1672	PFAM Archaeal ATPase
HCG51_RS08515	COG1752	Esterase of the alpha-beta hydrolase superfamily
HCG51_RS08525	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HCG51_RS08555	COG0314	molybdopterin synthase activity
HCG51_RS08570	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HCG51_RS08580	COG2723	6-phospho-beta-galactosidase activity
HCG51_RS08590	COG4783	chaperone-mediated protein folding
HCG51_RS08600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HCG51_RS08600	COG0426	domain, Protein
HCG51_RS08630	COG1426	Protein conserved in bacteria
HCG51_RS08635	COG2856	Zn peptidase
HCG51_RS08665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HCG51_RS08760	COG0202	RNA polymerase activity
HCG51_RS08770	COG0418	dihydroorotase activity
HCG51_RS08785	COG1192	Involved in chromosome partitioning
HCG51_RS08790	COG2205	protein histidine kinase activity
HCG51_RS08795	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HCG51_RS08935	COG1234	tRNA 3'-trailer cleavage
HCG51_RS08955	COG0745	RESPONSE REGULATOR receiver
HCG51_RS08960	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HCG51_RS08965	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HCG51_RS08975	COG1704	LemA family
HCG51_RS08980	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HCG51_RS09015	COG0515	serine threonine protein kinase
HCG51_RS09050	COG0539	negative regulation of cytoplasmic translation
HCG51_RS09055	COG0412	Dienelactone hydrolase
HCG51_RS09060	COG2188	Transcriptional regulator
HCG51_RS09080	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCG51_RS09090	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HCG51_RS09095	COG0740	serine-type endopeptidase activity
HCG51_RS09100	COG0544	peptidyl-prolyl cis-trans isomerase activity
HCG51_RS09105	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HCG51_RS09110	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HCG51_RS09115	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HCG51_RS09120	COG0464	growth
HCG51_RS09145	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HCG51_RS09150	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HCG51_RS09155	COG1012	belongs to the aldehyde dehydrogenase family
HCG51_RS09185	COG0804	urea catabolic process
HCG51_RS09195	COG0832	Belongs to the urease beta subunit family
HCG51_RS09200	COG0831	urea catabolic process
HCG51_RS09205	COG0829	nickel cation binding
HCG51_RS09225	COG0459	protein refolding
HCG51_RS09230	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HCG51_RS09240	COG2205	protein histidine kinase activity
HCG51_RS09240	COG0745	RESPONSE REGULATOR receiver
HCG51_RS09240	COG3292	Two component regulator propeller
HCG51_RS09245	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HCG51_RS09250	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HCG51_RS09255	COG2205	protein histidine kinase activity
HCG51_RS09260	COG0745	RESPONSE REGULATOR receiver
HCG51_RS09265	COG2203	Gaf domain
HCG51_RS09265	COG0840	transmembrane signaling receptor activity
HCG51_RS09275	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_RS09275	COG0515	serine threonine protein kinase
HCG51_RS09280	COG1940	carbohydrate kinase activity
HCG51_RS09295	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HCG51_RS09315	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HCG51_RS09335	COG3591	Belongs to the peptidase S1B family
HCG51_RS09335	COG1864	DNA RNA non-specific endonuclease
HCG51_RS09340	COG0517	IMP dehydrogenase activity
HCG51_RS09340	COG1994	Peptidase M50
HCG51_RS09370	COG0305	Participates in initiation and elongation during chromosome replication
HCG51_RS09370	COG1372	Participates in initiation and elongation during chromosome replication
HCG51_RS09375	COG0359	binds to the 23S rRNA
HCG51_RS09385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCG51_RS09405	COG1132	(ABC) transporter
HCG51_RS09445	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HCG51_RS09475	COG1515	deoxyribonuclease V activity
HCG51_RS09485	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HCG51_RS09515	COG4106	trans-aconitate 2-methyltransferase activity
HCG51_RS09530	COG1160	GTP binding
HCG51_RS09540	COG1304	FMN binding
HCG51_RS09545	COG0616	signal peptide processing
HCG51_RS09590	COG2070	2-Nitropropane dioxygenase
HCG51_RS09615	COG3956	TIGRFAM MazG family protein
HCG51_RS09620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCG51_RS09625	COG1012	belongs to the aldehyde dehydrogenase family
HCG51_RS09675	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HCG51_RS09680	COG0594	ribonuclease P activity
HCG51_RS09690	COG0706	membrane insertase activity
HCG51_RS09705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCG51_RS09720	COG5001	Diguanylate cyclase
HCG51_RS09720	COG1716	ATPase activity
HCG51_RS09725	COG2912	Transglutaminase-like superfamily
HCG51_RS09730	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HCG51_RS09735	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HCG51_RS09750	COG4251	negative regulation of phosphorylation
HCG51_RS09750	COG3706	GGDEF domain
HCG51_RS09750	COG2203	Gaf domain
HCG51_RS09750	COG5001	Diguanylate cyclase
HCG51_RS09755	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
HCG51_RS09765	COG0318	PFAM AMP-dependent synthetase and ligase
HCG51_RS09780	COG2166	iron-sulfur cluster assembly
HCG51_RS09815	COG0523	cobalamin synthesis protein
HCG51_RS09830	COG1201	RNA secondary structure unwinding
HCG51_RS09835	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HCG51_RS09840	COG0581	inorganic phosphate transmembrane transporter activity
HCG51_RS09845	COG0573	inorganic phosphate transmembrane transporter activity
HCG51_RS09860	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HCG51_RS09870	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCG51_RS09885	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HCG51_RS09890	COG0601	transmembrane transport
HCG51_RS09930	COG0129	dihydroxy-acid dehydratase activity
HCG51_RS09935	COG1063	alcohol dehydrogenase
HCG51_RS09985	COG0351	phosphomethylpyrimidine kinase
HCG51_RS09985	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HCG51_RS09985	COG0352	thiamine-phosphate diphosphorylase activity
HCG51_RS09995	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HCG51_RS10000	COG0713	ATP synthesis coupled electron transport
HCG51_RS10005	COG0839	Belongs to the complex I subunit 6 family
HCG51_RS10010	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCG51_RS10015	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HCG51_RS10030	COG0372	Belongs to the citrate synthase family
HCG51_RS10035	COG2062	phosphohistidine phosphatase, SixA
HCG51_RS10055	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HCG51_RS10065	COG0784	Response regulator, receiver
HCG51_RS10080	COG0840	transmembrane signaling receptor activity
HCG51_RS10080	COG2203	Gaf domain
HCG51_RS10085	COG2198	Histidine kinase
HCG51_RS10085	COG0643	Histidine kinase
HCG51_RS10085	COG0784	Response regulator, receiver
HCG51_RS10095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCG51_RS10120	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HCG51_RS10135	COG1696	Membrane protein involved in D-alanine export
HCG51_RS10155	COG2274	protein secretion by the type I secretion system
HCG51_RS10210	COG4585	Histidine kinase
HCG51_RS10220	COG2197	response regulator
HCG51_RS10230	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HCG51_RS10235	COG0751	glycine-tRNA ligase activity
HCG51_RS10265	COG1404	Belongs to the peptidase S8 family
HCG51_RS10310	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HCG51_RS10320	COG0671	phosphoesterase, PA-phosphatase related
HCG51_RS10365	COG3842	ATPase activity
HCG51_RS10400	COG0535	radical SAM domain protein
HCG51_RS10430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HCG51_RS10485	COG3540	Alkaline phosphatase
HCG51_RS10510	COG0640	Transcriptional regulator
HCG51_RS10515	COG0798	PFAM Bile acid sodium symporter
HCG51_RS10520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HCG51_RS10530	COG0431	NADPH-dependent FMN reductase
HCG51_RS10550	COG1959	2 iron, 2 sulfur cluster binding
HCG51_RS10680	COG4178	(ABC) transporter
HCG51_RS10690	COG3621	Patatin-like phospholipase
HCG51_RS10710	COG4178	(ABC) transporter
HCG51_RS10735	COG0318	PFAM AMP-dependent synthetase and ligase
HCG51_RS10740	COG1672	PFAM Archaeal ATPase
HCG51_RS10740	COG2319	Wd-40 repeat
HCG51_RS10765	COG0668	transmembrane transport
HCG51_RS10825	COG0529	Catalyzes the synthesis of activated sulfate
HCG51_RS10830	COG1682	transport, permease protein
HCG51_RS10910	COG1216	Glycosyl transferase, family 2
HCG51_RS10950	COG2814	Major facilitator Superfamily
HCG51_RS10995	COG0625	glutathione transferase activity
HCG51_RS11045	COG4191	Histidine kinase
HCG51_RS11050	COG3540	Alkaline phosphatase
HCG51_RS11245	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HCG51_RS11250	COG0776	regulation of translation
HCG51_RS11275	COG1468	defense response to virus
HCG51_RS11275	COG1518	maintenance of DNA repeat elements
HCG51_RS11305	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HCG51_RS11420	COG1372	Participates in initiation and elongation during chromosome replication
HCG51_RS11420	COG0305	Participates in initiation and elongation during chromosome replication
HCG51_RS11420	COG1372	Participates in initiation and elongation during chromosome replication
HCG51_RS11420	COG0305	Participates in initiation and elongation during chromosome replication
HCG51_RS11460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCG51_RS11540	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCG51_RS11545	COG1121	(ABC) transporter
HCG51_RS11550	COG0803	Belongs to the bacterial solute-binding protein 9 family
HCG51_RS11550	COG3443	Belongs to the bacterial solute-binding protein 9 family
HCG51_RS11555	COG3659	wide pore channel activity
HCG51_RS11560	COG2205	protein histidine kinase activity
HCG51_RS11560	COG0784	Response regulator, receiver
HCG51_RS11580	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HCG51_RS11590	COG2319	Wd-40 repeat
HCG51_RS11590	COG3903	Transcriptional regulator
HCG51_RS11595	COG0515	serine threonine protein kinase
HCG51_RS11595	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_RS11620	COG0300	oxidoreductase activity
HCG51_RS11625	COG0440	acetolactate synthase activity
HCG51_RS11640	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HCG51_RS11650	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HCG51_RS11670	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HCG51_RS11685	COG0067	glutamate synthase
HCG51_RS11685	COG0070	glutamate synthase
HCG51_RS11685	COG0069	glutamate synthase activity
HCG51_RS11695	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HCG51_RS11695	COG0662	Cupin 2, conserved barrel domain protein
HCG51_RS11700	COG0316	Belongs to the HesB IscA family
HCG51_RS11705	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HCG51_RS11710	COG0049	tRNA binding
HCG51_RS11715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HCG51_RS11720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HCG51_RS11725	COG0051	transcription antitermination factor activity, RNA binding
HCG51_RS11730	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HCG51_RS11735	COG0077	Prephenate dehydratase
HCG51_RS11745	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HCG51_RS11750	COG1530	ribonuclease E activity
HCG51_RS11755	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HCG51_RS11770	COG0436	Aminotransferase
HCG51_RS11780	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HCG51_RS11790	COG3335	DDE superfamily endonuclease
HCG51_RS11825	COG3437	response regulator, receiver
HCG51_RS11825	COG2770	Histidine kinase
HCG51_RS11850	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HCG51_RS11855	COG0745	RESPONSE REGULATOR receiver
HCG51_RS11865	COG2319	Wd-40 repeat
HCG51_RS11865	COG3903	Transcriptional regulator
HCG51_RS11890	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCG51_RS11890	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCG51_RS11905	COG1077	Cell shape determining protein MreB Mrl
HCG51_RS11910	COG0629	single-stranded DNA binding
HCG51_RS11925	COG0475	glutathione-regulated potassium exporter activity
HCG51_RS11935	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCG51_RS11945	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HCG51_RS11955	COG0142	geranyltranstransferase activity
HCG51_RS11975	COG1305	Transglutaminase-like
HCG51_RS11980	COG2052	Domain of unknown function (DUF370)
HCG51_RS11985	COG0194	GDP metabolic process
HCG51_RS12005	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HCG51_RS12010	COG2267	carboxylic ester hydrolase activity
HCG51_RS12020	COG0454	-acetyltransferase
HCG51_RS12035	COG2890	protein-(glutamine-N5) methyltransferase activity
HCG51_RS12045	COG4999	Histidine kinase
HCG51_RS12045	COG3437	response regulator, receiver
HCG51_RS12045	COG2205	protein histidine kinase activity
HCG51_RS12045	COG3850	Histidine kinase
HCG51_RS12050	COG0454	-acetyltransferase
HCG51_RS12065	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HCG51_RS12070	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HCG51_RS12075	COG0022	dehydrogenase e1 component
HCG51_RS12075	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCG51_RS12085	COG0113	porphobilinogen synthase activity
HCG51_RS12095	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HCG51_RS12120	COG0745	RESPONSE REGULATOR receiver
HCG51_RS12125	COG5002	protein histidine kinase activity
HCG51_RS12130	COG0438	transferase activity, transferring glycosyl groups
HCG51_RS12185	COG0438	transferase activity, transferring glycosyl groups
HCG51_RS12220	COG0217	transcriptional regulatory protein
HCG51_RS12230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCG51_RS12235	COG0784	Response regulator, receiver
HCG51_RS12235	COG2205	protein histidine kinase activity
HCG51_RS12245	COG0741	lytic transglycosylase activity
HCG51_RS12250	COG0805	protein transport
HCG51_RS12255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCG51_RS12260	COG3001	Fructosamine kinase
HCG51_RS12265	COG0612	Peptidase, M16
HCG51_RS12300	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HCG51_RS12315	COG0589	response to stress
HCG51_RS12320	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HCG51_RS12325	COG0268	Binds directly to 16S ribosomal RNA
HCG51_RS12330	COG0084	hydrolase, TatD family'
HCG51_RS12335	COG0085	RNA polymerase activity
HCG51_RS12340	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HCG51_RS12345	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HCG51_RS12360	COG1361	Conserved repeat domain
HCG51_RS12365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HCG51_RS12375	COG0596	Alpha beta hydrolase
HCG51_RS12395	COG4251	negative regulation of phosphorylation
HCG51_RS12405	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HCG51_RS12410	COG2202	Pas domain
HCG51_RS12410	COG2205	protein histidine kinase activity
HCG51_RS12420	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HCG51_RS12430	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HCG51_RS12435	COG3654	unkown
HCG51_RS12460	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HCG51_RS12480	COG0017	Asparaginyl-tRNA synthetase
HCG51_RS12490	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HCG51_RS12505	COG2319	Wd-40 repeat
HCG51_RS12505	COG3903	Transcriptional regulator
HCG51_RS12510	COG0589	response to stress
HCG51_RS12515	COG0126	phosphoglycerate kinase activity
HCG51_RS12545	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HCG51_RS12550	COG0572	uridine kinase
HCG51_RS12555	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HCG51_RS12590	COG2197	response regulator
HCG51_RS12595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCG51_RS12605	COG0840	transmembrane signaling receptor activity
HCG51_RS12605	COG2203	Gaf domain
HCG51_RS12625	COG2831	hemolysin activation secretion protein
HCG51_RS12670	COG5002	protein histidine kinase activity
HCG51_RS12685	COG0390	transport system, permease component
HCG51_RS12710	COG0824	Thioesterase
HCG51_RS12740	COG0501	Belongs to the peptidase M48B family
HCG51_RS12750	COG0656	L-ascorbic acid biosynthetic process
HCG51_RS12790	COG1836	PFAM Integral membrane protein DUF92
HCG51_RS12800	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HCG51_RS12815	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HCG51_RS12820	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HCG51_RS12860	COG0724	RNA recognition motif
HCG51_RS12875	COG0671	phosphoesterase, PA-phosphatase related
HCG51_RS12880	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HCG51_RS12880	COG0456	acetyltransferase
HCG51_RS12895	COG3958	Transketolase
HCG51_RS12925	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HCG51_RS12930	COG0406	alpha-ribazole phosphatase activity
HCG51_RS12940	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HCG51_RS12950	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HCG51_RS12965	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HCG51_RS13005	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HCG51_RS13010	COG0288	reversible hydration of carbon dioxide
HCG51_RS13015	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCG51_RS13060	COG1619	proteins homologs of microcin C7 resistance protein MccF
HCG51_RS13065	COG4310	Domain of unknown function (DUF2172)
HCG51_RS13070	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HCG51_RS13085	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HCG51_RS13105	COG0495	leucyl-tRNA aminoacylation
HCG51_RS13120	COG1595	DNA-templated transcription, initiation
HCG51_RS13130	COG1376	ErfK ybiS ycfS ynhG family protein
HCG51_RS13150	COG1136	(ABC) transporter
HCG51_RS13150	COG0577	efflux transmembrane transporter activity
HCG51_RS13180	COG1606	tRNA processing
HCG51_RS13190	COG3437	response regulator, receiver
HCG51_RS13190	COG4999	Histidine kinase
HCG51_RS13190	COG3850	Histidine kinase
HCG51_RS13190	COG2205	protein histidine kinase activity
HCG51_RS13205	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HCG51_RS13210	COG0745	RESPONSE REGULATOR receiver
HCG51_RS13215	COG2815	serine threonine protein kinase
HCG51_RS13215	COG0515	serine threonine protein kinase
HCG51_RS13225	COG0784	Response regulator, receiver
HCG51_RS13225	COG2198	Histidine kinase
HCG51_RS13225	COG2205	protein histidine kinase activity
HCG51_RS13240	COG1007	ATP synthesis coupled electron transport
HCG51_RS13250	COG0395	ABC-type sugar transport system, permease component
HCG51_RS13260	COG2010	Cytochrome c
HCG51_RS13265	COG2010	Cytochrome c
HCG51_RS13270	COG3794	PFAM blue (type 1) copper domain protein
HCG51_RS13275	COG0297	glycogen (starch) synthase activity
HCG51_RS13285	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_RS13285	COG0515	serine threonine protein kinase
HCG51_RS13295	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCG51_RS13300	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HCG51_RS13330	COG0456	acetyltransferase
HCG51_RS13335	COG1063	alcohol dehydrogenase
HCG51_RS13340	COG0306	phosphate transporter
HCG51_RS13345	COG0697	spore germination
HCG51_RS13355	COG0784	Response regulator, receiver
HCG51_RS13355	COG2205	protein histidine kinase activity
HCG51_RS13365	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HCG51_RS13370	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HCG51_RS13375	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HCG51_RS13395	COG1295	ribonuclease BN
HCG51_RS13420	COG4251	negative regulation of phosphorylation
HCG51_RS13420	COG3706	GGDEF domain
HCG51_RS13420	COG2203	Gaf domain
HCG51_RS13420	COG5001	Diguanylate cyclase
HCG51_RS13425	COG2205	protein histidine kinase activity
HCG51_RS13450	COG3240	lipase activity
HCG51_RS13480	COG1361	Conserved repeat domain
HCG51_RS13500	COG3266	domain, Protein
HCG51_RS13500	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HCG51_RS13515	COG0195	Participates in both transcription termination and antitermination
HCG51_RS13520	COG0779	Required for maturation of 30S ribosomal subunits
HCG51_RS13565	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HCG51_RS13595	COG0516	GMP reductase activity
HCG51_RS13595	COG0517	IMP dehydrogenase activity
HCG51_RS13600	COG0494	nUDIX hydrolase
HCG51_RS13610	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HCG51_RS13615	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HCG51_RS13620	COG0783	Belongs to the Dps family
HCG51_RS13645	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HCG51_RS13685	COG0251	oxidation-reduction process
HCG51_RS13695	COG1640	4-alpha-glucanotransferase
HCG51_RS13700	COG1426	Protein conserved in bacteria
HCG51_RS13705	COG1187	pseudouridine synthase activity
HCG51_RS13715	COG0575	Belongs to the CDS family
HCG51_RS13725	COG0515	serine threonine protein kinase
HCG51_RS13725	COG3266	domain, Protein
HCG51_RS13740	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HCG51_RS13745	COG0189	ligase activity
HCG51_RS13745	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HCG51_RS13750	COG4242	Belongs to the peptidase S51 family
HCG51_RS13760	COG0336	Belongs to the RNA methyltransferase TrmD family
HCG51_RS13765	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HCG51_RS13770	COG4166	transmembrane transport
HCG51_RS13775	COG1691	(AIR) carboxylase
HCG51_RS13785	COG0165	Argininosuccinate lyase
HCG51_RS13805	COG0025	NhaP-type Na H and K H
HCG51_RS13820	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HCG51_RS13825	COG0426	domain, Protein
HCG51_RS13825	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HCG51_RS13830	COG0426	domain, Protein
HCG51_RS13830	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HCG51_RS13835	COG0724	RNA recognition motif
HCG51_RS13855	COG1215	transferase activity, transferring glycosyl groups
HCG51_RS13860	COG0335	large ribosomal subunit rRNA binding
HCG51_RS13870	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HCG51_RS13875	COG0250	Participates in transcription elongation, termination and antitermination
HCG51_RS13880	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HCG51_RS13885	COG0081	regulation of translation
HCG51_RS13890	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HCG51_RS13895	COG0222	ribosome binding
HCG51_RS13905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCG51_RS13910	COG0431	NADPH-dependent FMN reductase
HCG51_RS13925	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HCG51_RS13935	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HCG51_RS13940	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HCG51_RS13945	COG0321	lipoyl(octanoyl) transferase activity
HCG51_RS13965	COG1126	abc transporter atp-binding protein
HCG51_RS13975	COG3903	Transcriptional regulator
HCG51_RS13975	COG2319	Wd-40 repeat
HCG51_RS13980	COG0515	serine threonine protein kinase
HCG51_RS13980	COG2815	serine threonine protein kinase
HCG51_RS14010	COG1846	Transcriptional regulator
HCG51_RS14025	COG0612	Peptidase, M16
HCG51_RS14030	COG4636	protein conserved in cyanobacteria
HCG51_RS14050	COG1505	serine-type exopeptidase activity
HCG51_RS14055	COG2198	Histidine kinase
HCG51_RS14055	COG0643	Histidine kinase
HCG51_RS14055	COG0784	Response regulator, receiver
HCG51_RS14090	COG0037	tRNA processing
HCG51_RS14105	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HCG51_RS14110	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HCG51_RS14115	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HCG51_RS14155	COG0438	transferase activity, transferring glycosyl groups
HCG51_RS14165	COG1181	Belongs to the D-alanine--D-alanine ligase family
HCG51_RS14175	COG0583	DNA-binding transcription factor activity
HCG51_RS14190	COG1028	Short-chain dehydrogenase reductase Sdr
HCG51_RS14195	COG1773	rubredoxin
HCG51_RS14210	COG1649	PFAM Uncharacterised BCR, COG1649
HCG51_RS14215	COG0515	serine threonine protein kinase
HCG51_RS14215	COG2815	serine threonine protein kinase
HCG51_RS14220	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HCG51_RS14235	COG0792	nuclease activity
HCG51_RS14245	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HCG51_RS14285	COG0569	domain protein
HCG51_RS14295	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HCG51_RS14300	COG2226	methyltransferase
HCG51_RS14305	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HCG51_RS14325	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HCG51_RS14330	COG0237	dephospho-CoA kinase activity
HCG51_RS14345	COG0312	modulator of DNA gyrase
HCG51_RS14365	COG0484	heat shock protein binding
HCG51_RS14370	COG0740	serine-type endopeptidase activity
HCG51_RS14375	COG0740	serine-type endopeptidase activity
HCG51_RS14380	COG2304	oxidoreductase activity
HCG51_RS14385	COG2304	oxidoreductase activity
HCG51_RS14390	COG0346	lactoylglutathione lyase activity
HCG51_RS14400	COG4956	integral membrane protein (PIN domain superfamily)
HCG51_RS14405	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HCG51_RS14435	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HCG51_RS14465	COG0489	protein tyrosine kinase activity
HCG51_RS14490	COG0438	transferase activity, transferring glycosyl groups
HCG51_RS14495	COG0438	transferase activity, transferring glycosyl groups
HCG51_RS14505	COG1215	transferase activity, transferring glycosyl groups
HCG51_RS14510	COG1442	glycosyl transferase family 8
HCG51_RS14515	COG0463	Glycosyl transferase, family 2
HCG51_RS14525	COG2244	polysaccharide biosynthetic process
HCG51_RS14530	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HCG51_RS14550	COG0501	Belongs to the peptidase M48B family
HCG51_RS14555	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HCG51_RS14565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCG51_RS14580	COG3033	Beta-eliminating lyase
HCG51_RS14600	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HCG51_RS14610	COG5002	protein histidine kinase activity
HCG51_RS14640	COG1943	Transposase
HCG51_RS14645	COG2161	toxin-antitoxin pair type II binding
HCG51_RS14655	COG2319	Wd-40 repeat
HCG51_RS14655	COG4249	Peptidase C14 caspase catalytic subunit p20
HCG51_RS14670	COG0436	Aminotransferase
HCG51_RS14675	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HCG51_RS14680	COG2124	cytochrome p450
HCG51_RS14705	COG3852	Histidine kinase
HCG51_RS14715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HCG51_RS14725	COG1982	Orn Lys Arg decarboxylase major
HCG51_RS14730	COG0644	oxidoreductase
HCG51_RS14740	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HCG51_RS14745	COG1555	photosystem II stabilization
HCG51_RS14750	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HCG51_RS14770	COG0515	serine threonine protein kinase
HCG51_RS14780	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HCG51_RS14805	COG4243	Vitamin k epoxide reductase
HCG51_RS14810	COG0434	BtpA family
HCG51_RS14815	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HCG51_RS14820	COG0513	Belongs to the DEAD box helicase family
HCG51_RS14830	COG0443	Heat shock 70 kDa protein
HCG51_RS14835	COG4689	acetoacetate decarboxylase
HCG51_RS14840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCG51_RS14845	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HCG51_RS14865	COG0768	penicillin binding
HCG51_RS14870	COG0802	atpase or kinase
HCG51_RS14875	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HCG51_RS14880	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HCG51_RS14885	COG0646	methionine synthase
HCG51_RS14885	COG1410	methionine synthase
HCG51_RS14900	COG0528	UMP kinase activity
HCG51_RS14905	COG0233	cytoplasmic translational termination
HCG51_RS14920	COG0398	Pfam SNARE associated Golgi protein
HCG51_RS14925	COG0463	Glycosyl transferase, family 2
HCG51_RS14955	COG0411	ABC transporter
HCG51_RS14980	COG0837	glucose binding
HCG51_RS14995	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCG51_RS15000	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HCG51_RS15005	COG3118	belongs to the thioredoxin family
HCG51_RS15015	COG0583	DNA-binding transcription factor activity
HCG51_RS15020	COG0515	serine threonine protein kinase
HCG51_RS15030	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HCG51_RS15035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCG51_RS15045	COG0561	phosphatase activity
HCG51_RS15055	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HCG51_RS15055	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HCG51_RS15080	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HCG51_RS15085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCG51_RS15110	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HCG51_RS15125	COG0745	RESPONSE REGULATOR receiver
HCG51_RS15130	COG5002	protein histidine kinase activity
HCG51_RS15135	COG0704	Plays a role in the regulation of phosphate uptake
HCG51_RS15140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCG51_RS15145	COG3659	wide pore channel activity
HCG51_RS15160	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HCG51_RS15160	COG1215	transferase activity, transferring glycosyl groups
HCG51_RS15170	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HCG51_RS15200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCG51_RS15205	COG2226	methyltransferase
HCG51_RS15210	COG1690	Belongs to the RtcB family
HCG51_RS15215	COG2201	protein-glutamate methylesterase activity
HCG51_RS15220	COG0385	Bile acid
HCG51_RS15225	COG0667	Aldo Keto reductase
HCG51_RS15240	COG1899	peptidyl-lysine modification to peptidyl-hypusine
HCG51_RS15245	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCG51_RS15265	COG2124	cytochrome p450
HCG51_RS15280	COG0586	Pfam SNARE associated Golgi protein
HCG51_RS15305	COG5592	hemerythrin HHE cation binding domain
HCG51_RS15320	COG1473	amidohydrolase
HCG51_RS15335	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HCG51_RS15350	COG1028	Short-chain dehydrogenase reductase Sdr
HCG51_RS15360	COG1247	-acetyltransferase
HCG51_RS15375	COG2205	protein histidine kinase activity
HCG51_RS15395	COG1132	(ABC) transporter
HCG51_RS15430	COG2501	S4 domain
HCG51_RS15445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCG51_RS15450	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HCG51_RS15465	COG5002	protein histidine kinase activity
HCG51_RS15475	COG1442	glycosyl transferase family 8
HCG51_RS15475	COG1216	Glycosyl transferase, family 2
HCG51_RS15480	COG1442	glycosyl transferase family 8
HCG51_RS15480	COG1216	Glycosyl transferase, family 2
HCG51_RS15515	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HCG51_RS15520	COG5002	protein histidine kinase activity
HCG51_RS15520	COG0784	Response regulator, receiver
HCG51_RS15520	COG2198	Histidine kinase
HCG51_RS15545	COG0489	protein tyrosine kinase activity
HCG51_RS15610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCG51_RS15630	COG0438	transferase activity, transferring glycosyl groups
HCG51_RS15645	COG0463	Glycosyl transferase, family 2
HCG51_RS15655	COG0297	glycogen (starch) synthase activity
HCG51_RS15655	COG0438	transferase activity, transferring glycosyl groups
HCG51_RS15665	COG0438	transferase activity, transferring glycosyl groups
HCG51_RS15690	COG0110	maltose O-acetyltransferase activity
HCG51_RS15705	COG0463	Glycosyl transferase, family 2
HCG51_RS15715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCG51_RS15725	COG4294	response to UV
HCG51_RS15730	COG0443	Heat shock 70 kDa protein
HCG51_RS15745	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HCG51_RS15765	COG1819	glycosyl
HCG51_RS15810	COG0667	Aldo Keto reductase
HCG51_RS15820	COG2337	Toxic component of a toxin-antitoxin (TA) module
HCG51_RS15875	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HCG51_RS15900	COG0583	DNA-binding transcription factor activity
HCG51_RS15915	COG4451	ribulose bisphosphate carboxylase, small
HCG51_RS15915	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HCG51_RS15920	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HCG51_RS15925	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HCG51_RS15930	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HCG51_RS15935	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HCG51_RS15940	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCG51_RS15950	COG0674	pyruvate-flavodoxin oxidoreductase activity
HCG51_RS15950	COG1013	pyruvate-flavodoxin oxidoreductase activity
HCG51_RS15950	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HCG51_RS15950	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HCG51_RS15980	COG2319	Wd-40 repeat
HCG51_RS15980	COG3903	Transcriptional regulator
HCG51_RS15985	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HCG51_RS16000	COG4232	protein-disulfide reductase activity
HCG51_RS16005	COG1333	cytochrome c biogenesis protein
HCG51_RS16010	COG0300	oxidoreductase activity
HCG51_RS16060	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HCG51_RS16065	COG4251	negative regulation of phosphorylation
HCG51_RS16075	COG2205	protein histidine kinase activity
HCG51_RS16080	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HCG51_RS16095	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HCG51_RS16100	COG0745	RESPONSE REGULATOR receiver
HCG51_RS16120	COG0134	indole-3-glycerol-phosphate synthase activity
HCG51_RS16125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCG51_RS16150	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HCG51_RS16165	COG0483	inositol monophosphate 1-phosphatase activity
HCG51_RS16170	COG0484	heat shock protein binding
HCG51_RS16175	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HCG51_RS16180	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCG51_RS16190	COG0288	reversible hydration of carbon dioxide
HCG51_RS16200	COG2267	carboxylic ester hydrolase activity
HCG51_RS16215	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HCG51_RS16230	COG2205	protein histidine kinase activity
HCG51_RS16230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCG51_RS16250	COG0562	UDP-galactopyranose mutase
HCG51_RS16275	COG3781	membrane
HCG51_RS16280	COG2234	aminopeptidase activity
HCG51_RS16285	COG0443	Heat shock 70 kDa protein
HCG51_RS16290	COG0484	heat shock protein binding
HCG51_RS16300	COG1598	PFAM Uncharacterised protein family UPF0150
HCG51_RS16325	COG0436	Aminotransferase
HCG51_RS16385	COG0745	RESPONSE REGULATOR receiver
HCG51_RS16395	COG0784	Response regulator, receiver
HCG51_RS16395	COG2205	protein histidine kinase activity
HCG51_RS16395	COG5002	protein histidine kinase activity
HCG51_RS16410	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HCG51_RS16410	COG0284	orotidine-5'-phosphate decarboxylase activity
HCG51_RS16415	COG0628	permease
HCG51_RS16450	COG1053	succinate dehydrogenase
HCG51_RS16460	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
HCG51_RS16485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCG51_RS16505	COG0542	response to heat
HCG51_RS16520	COG3266	domain, Protein
HCG51_RS16520	COG0515	serine threonine protein kinase
HCG51_RS16525	COG0515	serine threonine protein kinase
HCG51_RS16535	COG0616	signal peptide processing
HCG51_RS16545	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HCG51_RS16560	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HCG51_RS16565	COG1132	(ABC) transporter
HCG51_RS16590	COG0784	Response regulator, receiver
HCG51_RS16595	COG4251	negative regulation of phosphorylation
HCG51_RS16615	COG0072	phenylalanine-tRNA ligase activity
HCG51_RS16615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCG51_RS16640	COG2226	methyltransferase
HCG51_RS16665	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HCG51_RS16695	COG3920	Histidine kinase
HCG51_RS16700	COG5002	protein histidine kinase activity
HCG51_RS16705	COG0788	formyltetrahydrofolate deformylase activity
HCG51_RS16725	COG1131	(ABC) transporter
HCG51_RS16785	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HCG51_RS16800	COG5002	protein histidine kinase activity
HCG51_RS16800	COG0784	Response regulator, receiver
HCG51_RS16810	COG0297	glycogen (starch) synthase activity
HCG51_RS16815	COG0181	hydroxymethylbilane synthase activity
HCG51_RS16850	COG2319	Wd-40 repeat
HCG51_RS16850	COG1672	PFAM Archaeal ATPase
HCG51_RS16860	COG1803	Methylglyoxal synthase
HCG51_RS16860	COG1597	lipid kinase activity
HCG51_RS16875	COG2815	serine threonine protein kinase
HCG51_RS16875	COG0515	serine threonine protein kinase
HCG51_RS16880	COG0475	glutathione-regulated potassium exporter activity
HCG51_RS16920	COG5002	protein histidine kinase activity
HCG51_RS16935	COG2319	Wd-40 repeat
HCG51_RS16935	COG1672	PFAM Archaeal ATPase
HCG51_RS16950	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_RS16950	COG0515	serine threonine protein kinase
HCG51_RS17000	COG0402	S-adenosylhomocysteine deaminase activity
HCG51_RS17005	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HCG51_RS17010	COG0271	Belongs to the BolA IbaG family
HCG51_RS17020	COG4935	Belongs to the peptidase S8 family
HCG51_RS17020	COG1404	Belongs to the peptidase S8 family
HCG51_RS17030	COG0590	tRNA wobble adenosine to inosine editing
HCG51_RS17045	COG1420	regulation of RNA biosynthetic process
HCG51_RS17065	COG4221	oxidoreductase activity
HCG51_RS17075	COG0702	epimerase
HCG51_RS17090	COG0666	response to abiotic stimulus
HCG51_RS17100	COG1950	PFAM Membrane protein of
HCG51_RS17115	COG1797	cobyrinic acid a,c-diamide synthase activity
HCG51_RS17125	COG1615	UPF0182 protein
HCG51_RS17135	COG0052	Belongs to the universal ribosomal protein uS2 family
HCG51_RS17140	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HCG51_RS17155	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HCG51_RS17160	COG0842	Transport permease protein
HCG51_RS17175	COG1129	ABC transporter
HCG51_RS17175	COG0842	Transport permease protein
HCG51_RS17180	COG1131	(ABC) transporter
HCG51_RS17190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCG51_RS17200	COG2205	protein histidine kinase activity
HCG51_RS17200	COG0784	Response regulator, receiver
HCG51_RS17210	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HCG51_RS17235	COG0012	GTP binding
HCG51_RS17245	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
HCG51_RS17265	COG0724	RNA recognition motif
HCG51_RS17270	COG0724	RNA recognition motif
HCG51_RS17280	COG3540	Alkaline phosphatase
HCG51_RS17295	COG3631	Ketosteroid isomerase-related protein
HCG51_RS17300	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HCG51_RS17305	COG0546	phosphoglycolate phosphatase activity
HCG51_RS17320	COG1136	(ABC) transporter
HCG51_RS17335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HCG51_RS17340	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HCG51_RS17360	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HCG51_RS17365	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HCG51_RS17400	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HCG51_RS17405	COG2197	response regulator
HCG51_RS17415	COG0154	amidase activity
HCG51_RS17435	COG0739	heme binding
HCG51_RS17435	COG0741	lytic transglycosylase activity
HCG51_RS17435	COG1196	nuclear chromosome segregation
HCG51_RS17460	COG3659	wide pore channel activity
HCG51_RS17465	COG0725	ABC transporter, periplasmic molybdate-binding protein
HCG51_RS17500	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HCG51_RS17505	COG0725	ABC transporter, periplasmic molybdate-binding protein
HCG51_RS17525	COG2366	antibiotic biosynthetic process
HCG51_RS17555	COG0758	DNA mediated transformation
HCG51_RS17555	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HCG51_RS17605	COG2843	Capsule synthesis protein
HCG51_RS17610	COG0724	RNA recognition motif
HCG51_RS17625	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HCG51_RS17625	COG1754	DNA topoisomerase type I activity
HCG51_RS17630	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HCG51_RS17640	COG1480	7TM receptor with intracellular HD hydrolase
HCG51_RS17660	COG4399	Belongs to the UPF0754 family
HCG51_RS17665	COG2226	methyltransferase
HCG51_RS17670	COG2204	response regulator
HCG51_RS17680	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HCG51_RS17685	COG0581	inorganic phosphate transmembrane transporter activity
HCG51_RS17690	COG0573	inorganic phosphate transmembrane transporter activity
HCG51_RS17695	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HCG51_RS17700	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HCG51_RS17715	COG0484	heat shock protein binding
HCG51_RS17720	COG0745	RESPONSE REGULATOR receiver
HCG51_RS17730	COG2814	Major facilitator Superfamily
HCG51_RS17740	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HCG51_RS17750	COG0275	rRNA processing
HCG51_RS17820	COG3240	lipase activity
HCG51_RS17830	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HCG51_RS17855	COG0460	homoserine dehydrogenase
HCG51_RS17860	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HCG51_RS17870	COG0572	uridine kinase
HCG51_RS17875	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HCG51_RS17880	COG2205	protein histidine kinase activity
HCG51_RS17880	COG0784	Response regulator, receiver
HCG51_RS17890	COG2329	Antibiotic biosynthesis monooxygenase
HCG51_RS17895	COG0288	reversible hydration of carbon dioxide
HCG51_RS17930	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HCG51_RS17940	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HCG51_RS17945	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HCG51_RS17950	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HCG51_RS17955	COG3977	Valine--pyruvate aminotransferase
HCG51_RS17960	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HCG51_RS17995	COG2022	thiamine diphosphate biosynthetic process
HCG51_RS17995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCG51_RS18060	COG0438	transferase activity, transferring glycosyl groups
HCG51_RS18080	COG1216	Glycosyl transferase, family 2
HCG51_RS18085	COG0297	glycogen (starch) synthase activity
HCG51_RS18090	COG1132	(ABC) transporter
HCG51_RS18095	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCG51_RS18100	COG0489	protein tyrosine kinase activity
HCG51_RS18125	COG1216	Glycosyl transferase, family 2
HCG51_RS18130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HCG51_RS18135	COG0579	oxidoreductase
HCG51_RS18155	COG4245	von Willebrand factor, type A
HCG51_RS18170	COG3631	Ketosteroid isomerase-related protein
HCG51_RS18175	COG5002	protein histidine kinase activity
HCG51_RS18175	COG2205	protein histidine kinase activity
HCG51_RS18175	COG0784	Response regulator, receiver
HCG51_RS18210	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HCG51_RS18220	COG0312	modulator of DNA gyrase
HCG51_RS18230	COG0215	cysteine-tRNA ligase activity
HCG51_RS18235	COG0523	cobalamin synthesis protein
HCG51_RS18240	COG1490	D-aminoacyl-tRNA deacylase activity
HCG51_RS18250	COG0521	Mo-molybdopterin cofactor biosynthetic process
HCG51_RS18255	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HCG51_RS18275	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HCG51_RS18285	COG0039	L-malate dehydrogenase activity
HCG51_RS18315	COG3409	Peptidoglycan-binding domain 1 protein
HCG51_RS18315	COG3429	Glucose-6-phosphate dehydrogenase subunit
HCG51_RS18320	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HCG51_RS18325	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HCG51_RS18330	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HCG51_RS18335	COG0724	RNA recognition motif
HCG51_RS18355	COG0259	pyridoxamine-phosphate oxidase activity
HCG51_RS18360	COG1045	serine acetyltransferase
HCG51_RS18370	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HCG51_RS18380	COG1494	fructose-1,6-bisphosphatase
HCG51_RS18385	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HCG51_RS18395	COG4636	protein conserved in cyanobacteria
HCG51_RS18405	COG0640	Transcriptional regulator
HCG51_RS18435	COG0166	Belongs to the GPI family
HCG51_RS18450	COG0515	serine threonine protein kinase
HCG51_RS18450	COG3266	domain, Protein
HCG51_RS18455	COG0515	serine threonine protein kinase
HCG51_RS18455	COG3266	domain, Protein
HCG51_RS18465	COG3266	domain, Protein
HCG51_RS18465	COG0515	serine threonine protein kinase
HCG51_RS18470	COG1131	(ABC) transporter
HCG51_RS18470	COG0842	Transport permease protein
HCG51_RS18470	COG1716	ATPase activity
HCG51_RS18635	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HCG51_RS18650	COG3266	domain, Protein
HCG51_RS18650	COG0515	serine threonine protein kinase
HCG51_RS18660	COG1902	pentaerythritol trinitrate reductase activity
HCG51_RS18670	COG0667	Aldo Keto reductase
HCG51_RS18675	COG2205	protein histidine kinase activity
HCG51_RS18695	COG0438	transferase activity, transferring glycosyl groups
HCG51_RS18710	COG0438	transferase activity, transferring glycosyl groups
HCG51_RS18715	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCG51_RS18720	COG4249	Peptidase C14 caspase catalytic subunit p20
HCG51_RS18720	COG2319	Wd-40 repeat
HCG51_RS18750	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HCG51_RS18760	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_RS18760	COG0515	serine threonine protein kinase
HCG51_RS18765	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_RS18765	COG0515	serine threonine protein kinase
HCG51_RS18770	COG2319	Wd-40 repeat
HCG51_RS18780	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_RS18780	COG0515	serine threonine protein kinase
HCG51_RS18795	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCG51_RS18805	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HCG51_RS18835	COG2205	protein histidine kinase activity
HCG51_RS18835	COG0784	Response regulator, receiver
HCG51_RS18835	COG5002	protein histidine kinase activity
HCG51_RS18840	COG0673	inositol 2-dehydrogenase activity
HCG51_RS18845	COG0571	ribonuclease III activity
HCG51_RS18860	COG0598	Magnesium transport protein CorA
HCG51_RS18870	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HCG51_RS18875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCG51_RS18880	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HCG51_RS18890	COG0572	uridine kinase
HCG51_RS18905	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HCG51_RS18910	COG0308	aminopeptidase N
HCG51_RS18920	COG2226	methyltransferase
HCG51_RS18935	COG0484	heat shock protein binding
HCG51_RS18940	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HCG51_RS18945	COG1959	2 iron, 2 sulfur cluster binding
HCG51_RS18950	COG3659	wide pore channel activity
HCG51_RS18955	COG2154	pterin-4-alpha-carbinolamine dehydratase
HCG51_RS18970	COG1122	ATPase activity
HCG51_RS18975	COG3688	RNA-binding protein containing a PIN domain
HCG51_RS18990	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_RS18990	COG0515	serine threonine protein kinase
HCG51_RS18995	COG0697	spore germination
HCG51_RS19005	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HCG51_RS19020	COG4771	TonB-dependent receptor
HCG51_RS19030	COG0784	Response regulator, receiver
HCG51_RS19035	COG0745	RESPONSE REGULATOR receiver
HCG51_RS19035	COG4191	Histidine kinase
HCG51_RS19035	COG2205	protein histidine kinase activity
HCG51_RS19050	COG2010	Cytochrome c
HCG51_RS19060	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HCG51_RS19065	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HCG51_RS19080	COG3850	Histidine kinase
HCG51_RS19080	COG3437	response regulator, receiver
HCG51_RS19080	COG2205	protein histidine kinase activity
HCG51_RS19080	COG4999	Histidine kinase
HCG51_RS19090	COG0481	GTPase activity
HCG51_RS19105	COG1104	cysteine desulfurase activity
HCG51_RS19115	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HCG51_RS19175	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HCG51_RS19190	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HCG51_RS19190	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HCG51_RS19195	COG0667	Aldo Keto reductase
HCG51_RS19200	COG4178	(ABC) transporter
HCG51_RS19210	COG0482	sulfurtransferase activity
HCG51_RS19225	COG3937	granule-associated protein
HCG51_RS19230	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HCG51_RS19235	COG0631	protein serine/threonine phosphatase activity
HCG51_RS19245	COG0515	serine threonine protein kinase
HCG51_RS19265	COG0395	ABC-type sugar transport system, permease component
HCG51_RS19270	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HCG51_RS19275	COG5322	oxidoreductase activity
HCG51_RS19280	COG0825	malonyl-CoA metabolic process
HCG51_RS19285	COG0300	oxidoreductase activity
HCG51_RS19290	COG0302	gtp cyclohydrolase
HCG51_RS19295	COG0135	phosphoribosylanthranilate isomerase activity
HCG51_RS19305	COG1994	Peptidase M50
HCG51_RS19305	COG0517	IMP dehydrogenase activity
HCG51_RS19315	COG4636	protein conserved in cyanobacteria
HCG51_RS19320	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HCG51_RS19320	COG0617	tRNA 3'-terminal CCA addition
HCG51_RS19320	COG0517	IMP dehydrogenase activity
HCG51_RS19330	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HCG51_RS19345	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HCG51_RS19350	COG3239	Fatty acid desaturase
HCG51_RS19355	COG3239	Fatty acid desaturase
HCG51_RS19360	COG3239	Fatty acid desaturase
HCG51_RS19370	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HCG51_RS19375	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
HCG51_RS19380	COG0484	heat shock protein binding
HCG51_RS19400	COG3335	DDE superfamily endonuclease
HCG51_RS19405	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HCG51_RS19405	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HCG51_RS19420	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HCG51_RS19425	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HCG51_RS19440	COG0133	tryptophan synthase activity
HCG51_RS19445	COG0023	Translation Initiation Factor
HCG51_RS19450	COG0401	homolog of Blt101
HCG51_RS19485	COG0430	RNA-3'-phosphate cyclase activity
HCG51_RS19490	COG0514	ATP-dependent DNA helicase (RecQ)
HCG51_RS19505	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HCG51_RS19535	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HCG51_RS19540	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HCG51_RS19580	COG0784	Response regulator, receiver
HCG51_RS19585	COG3850	Histidine kinase
HCG51_RS19585	COG4999	Histidine kinase
HCG51_RS19585	COG3437	response regulator, receiver
HCG51_RS19585	COG2205	protein histidine kinase activity
HCG51_RS19590	COG2205	protein histidine kinase activity
HCG51_RS19595	COG0784	Response regulator, receiver
HCG51_RS19600	COG4251	negative regulation of phosphorylation
HCG51_RS19605	COG2197	response regulator
HCG51_RS19615	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HCG51_RS19620	COG0515	serine threonine protein kinase
HCG51_RS19620	COG2815	serine threonine protein kinase
HCG51_RS19640	COG0107	imidazoleglycerol-phosphate synthase activity
HCG51_RS19645	COG2255	four-way junction helicase activity
HCG51_RS19660	COG3848	Pyruvate phosphate dikinase
HCG51_RS19660	COG0574	Belongs to the PEP-utilizing enzyme family
HCG51_RS19675	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HCG51_RS19680	COG1070	Carbohydrate kinase
HCG51_RS19705	COG1666	GTP binding
HCG51_RS19715	COG0857	belongs to the CobB CobQ family
HCG51_RS19725	COG1215	transferase activity, transferring glycosyl groups
HCG51_RS19730	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HCG51_RS19745	COG1733	regulation of RNA biosynthetic process
HCG51_RS19755	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HCG51_RS19790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCG51_RS19815	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HCG51_RS19835	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HCG51_RS19845	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCG51_RS19860	COG5001	Diguanylate cyclase
HCG51_RS19860	COG3706	GGDEF domain
HCG51_RS19860	COG4251	negative regulation of phosphorylation
HCG51_RS19860	COG2203	Gaf domain
HCG51_RS19875	COG0277	FAD linked oxidase domain protein
HCG51_RS19890	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HCG51_RS19895	COG0187	DNA topoisomerase II activity
HCG51_RS19895	COG1372	Participates in initiation and elongation during chromosome replication
HCG51_RS19900	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HCG51_RS19905	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HCG51_RS19910	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HCG51_RS19950	COG2084	Dehydrogenase
HCG51_RS19970	COG2203	Gaf domain
HCG51_RS19975	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HCG51_RS19990	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HCG51_RS20005	COG0596	Alpha beta hydrolase
HCG51_RS20010	COG1937	Protein conserved in bacteria
HCG51_RS20015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCG51_RS20025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCG51_RS20030	COG1136	(ABC) transporter
HCG51_RS20030	COG0577	efflux transmembrane transporter activity
HCG51_RS20035	COG1136	(ABC) transporter
HCG51_RS20045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCG51_RS20050	COG1136	(ABC) transporter
HCG51_RS20050	COG0577	efflux transmembrane transporter activity
HCG51_RS20075	COG0300	oxidoreductase activity
HCG51_RS20085	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HCG51_RS20090	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HCG51_RS20090	COG0426	domain, Protein
HCG51_RS20100	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HCG51_RS20100	COG0426	domain, Protein
HCG51_RS20115	COG0649	NAD binding
HCG51_RS20130	COG0515	serine threonine protein kinase
HCG51_RS20135	COG0538	isocitrate dehydrogenase activity
HCG51_RS20160	COG0357	Ribosomal RNA small subunit methyltransferase G
HCG51_RS20165	COG1122	ATPase activity
HCG51_RS20215	COG1132	(ABC) transporter
HCG51_RS20225	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HCG51_RS20240	COG2234	aminopeptidase activity
HCG51_RS20250	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HCG51_RS20260	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HCG51_RS20320	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HCG51_RS20320	COG2169	Transcriptional regulator
HCG51_RS20325	COG3621	Patatin-like phospholipase
HCG51_RS20350	COG1598	PFAM Uncharacterised protein family UPF0150
HCG51_RS20355	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HCG51_RS20360	COG1253	flavin adenine dinucleotide binding
HCG51_RS20370	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HCG51_RS20420	COG5002	protein histidine kinase activity
HCG51_RS20425	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HCG51_RS20430	COG2201	protein-glutamate methylesterase activity
HCG51_RS20445	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HCG51_RS20460	COG3659	wide pore channel activity
HCG51_RS20465	COG3659	wide pore channel activity
HCG51_RS20470	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HCG51_RS20480	COG0129	dihydroxy-acid dehydratase activity
HCG51_RS20485	COG0583	DNA-binding transcription factor activity
HCG51_RS20495	COG4251	negative regulation of phosphorylation
HCG51_RS20495	COG3706	GGDEF domain
HCG51_RS20495	COG5001	Diguanylate cyclase
HCG51_RS20495	COG2203	Gaf domain
HCG51_RS20500	COG5002	protein histidine kinase activity
HCG51_RS20505	COG0784	Response regulator, receiver
HCG51_RS20510	COG4251	negative regulation of phosphorylation
HCG51_RS20525	COG0574	Belongs to the PEP-utilizing enzyme family
HCG51_RS20525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HCG51_RS20535	COG1388	LysM domain
HCG51_RS20535	COG3942	CHAP domain
HCG51_RS20560	COG2326	polyphosphate kinase activity
HCG51_RS20575	COG0328	RNA-DNA hybrid ribonuclease activity
HCG51_RS20595	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HCG51_RS20600	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HCG51_RS20660	COG1215	transferase activity, transferring glycosyl groups
HCG51_RS20665	COG0793	Belongs to the peptidase S41A family
HCG51_RS20700	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HCG51_RS20700	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HCG51_RS20710	COG0456	acetyltransferase
HCG51_RS20735	COG2177	Part of the ABC transporter FtsEX involved in
HCG51_RS20750	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HCG51_RS20760	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HCG51_RS20765	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HCG51_RS20770	COG0750	zinc metalloprotease
HCG51_RS20775	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HCG51_RS20800	COG2205	protein histidine kinase activity
HCG51_RS20805	COG1361	Conserved repeat domain
HCG51_RS20825	COG0419	ATPase involved in DNA repair
HCG51_RS20840	COG0668	transmembrane transport
HCG51_RS20865	COG2321	neutral zinc metallopeptidase
HCG51_RS20875	COG0159	tryptophan synthase activity
HCG51_RS20910	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HCG51_RS20915	COG0009	L-threonylcarbamoyladenylate synthase
HCG51_RS20925	COG0667	Aldo Keto reductase
HCG51_RS20930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HCG51_RS20940	COG0438	transferase activity, transferring glycosyl groups
HCG51_RS20945	COG0010	Belongs to the arginase family
HCG51_RS20980	COG0793	Belongs to the peptidase S41A family
HCG51_RS20990	COG5002	protein histidine kinase activity
HCG51_RS21000	COG1022	Amp-dependent synthetase and ligase
HCG51_RS21045	COG2124	cytochrome p450
HCG51_RS21060	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HCG51_RS21065	COG0003	Pfam Anion-transporting ATPase
HCG51_RS21095	COG0438	transferase activity, transferring glycosyl groups
HCG51_RS21105	COG4636	protein conserved in cyanobacteria
HCG51_RS21110	COG0469	pyruvate kinase activity
HCG51_RS21125	COG1598	PFAM Uncharacterised protein family UPF0150
HCG51_RS21150	COG0497	DNA recombination
HCG51_RS21165	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HCG51_RS21220	COG1429	ligase activity, forming nitrogen-metal bonds
HCG51_RS21240	COG4451	ribulose bisphosphate carboxylase, small
HCG51_RS21250	COG1850	ribulose-bisphosphate carboxylase activity
HCG51_RS21260	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HCG51_RS21280	COG0542	response to heat
HCG51_RS21305	COG1773	rubredoxin
HCG51_RS21310	COG2081	HI0933 family
HCG51_RS21315	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCG51_RS21325	COG0297	glycogen (starch) synthase activity
HCG51_RS21330	COG3307	-O-antigen
HCG51_RS21335	COG0438	transferase activity, transferring glycosyl groups
HCG51_RS21335	COG0297	glycogen (starch) synthase activity
HCG51_RS21340	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HCG51_RS21350	COG3507	Belongs to the glycosyl hydrolase 43 family
HCG51_RS21350	COG3693	PFAM glycoside hydrolase, family 10
HCG51_RS21350	COG2382	esterase
HCG51_RS21355	COG0489	protein tyrosine kinase activity
HCG51_RS21360	COG1361	Conserved repeat domain
HCG51_RS21365	COG0110	maltose O-acetyltransferase activity
HCG51_RS21370	COG5001	Diguanylate cyclase
HCG51_RS21370	COG5002	protein histidine kinase activity
HCG51_RS21370	COG3447	MASE1 domain protein
HCG51_RS21375	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HCG51_RS21380	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HCG51_RS21390	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HCG51_RS21410	COG2814	Major facilitator Superfamily
HCG51_RS21415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HCG51_RS21425	COG0589	response to stress
HCG51_RS21445	COG1028	Short-chain dehydrogenase reductase Sdr
HCG51_RS21455	COG1361	Conserved repeat domain
HCG51_RS21475	COG4948	Mandelate Racemase Muconate Lactonizing
HCG51_RS21515	COG1193	negative regulation of DNA recombination
HCG51_RS21520	COG0516	GMP reductase activity
HCG51_RS21525	COG3118	belongs to the thioredoxin family
HCG51_RS21550	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCG51_RS21555	COG0204	Acyl-transferase
HCG51_RS21580	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HCG51_RS21585	COG0416	fatty acid biosynthetic process
HCG51_RS21590	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCG51_RS21595	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HCG51_RS21605	COG0628	permease
HCG51_RS21620	COG1575	Belongs to the MenA family. Type 1 subfamily
HCG51_RS21630	COG0318	PFAM AMP-dependent synthetase and ligase
HCG51_RS21635	COG0824	Thioesterase
HCG51_RS21680	COG0811	peptide transport
HCG51_RS21685	COG0848	biopolymer transport protein
HCG51_RS21710	COG0408	coproporphyrinogen oxidase activity
HCG51_RS21720	COG0489	protein tyrosine kinase activity
HCG51_RS21725	COG0772	Belongs to the SEDS family
HCG51_RS21740	COG0589	response to stress
HCG51_RS21740	COG0475	glutathione-regulated potassium exporter activity
HCG51_RS21745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCG51_RS21750	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HCG51_RS21765	COG1834	amidinotransferase
HCG51_RS21790	COG0504	CTP synthase activity
HCG51_RS21800	COG1940	carbohydrate kinase activity
HCG51_RS21810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCG51_RS21815	COG0492	ferredoxin-NADP+ reductase activity
HCG51_RS21825	COG4968	Prepilin-type N-terminal cleavage methylation domain
HCG51_RS21845	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HCG51_RS21870	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HCG51_RS21870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCG51_RS21875	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
HCG51_RS21875	COG0028	Belongs to the TPP enzyme family
HCG51_RS21900	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_RS21900	COG0515	serine threonine protein kinase
HCG51_RS21910	COG5002	protein histidine kinase activity
HCG51_RS21915	COG1187	pseudouridine synthase activity
HCG51_RS21920	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HCG51_RS21930	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HCG51_RS21950	COG1253	flavin adenine dinucleotide binding
HCG51_RS21955	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HCG51_RS21960	COG0673	inositol 2-dehydrogenase activity
HCG51_RS21965	COG0586	Pfam SNARE associated Golgi protein
HCG51_RS21980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HCG51_RS21985	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HCG51_RS22000	COG0351	phosphomethylpyrimidine kinase
HCG51_RS22030	COG0584	glycerophosphoryl diester phosphodiesterase
HCG51_RS22035	COG0667	Aldo Keto reductase
HCG51_RS22040	COG1309	transcriptional regulator
HCG51_RS22055	COG1252	NADH dehydrogenase
HCG51_RS22065	COG0745	RESPONSE REGULATOR receiver
HCG51_RS22075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HCG51_RS22080	COG0814	amino acid
HCG51_RS22085	COG2205	protein histidine kinase activity
HCG51_RS22085	COG0784	Response regulator, receiver
HCG51_RS22090	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HCG51_RS22095	COG0681	Belongs to the peptidase S26 family
HCG51_RS22105	COG1063	alcohol dehydrogenase
HCG51_RS22120	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HCG51_RS22125	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HCG51_RS22135	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HCG51_RS22135	COG3266	domain, Protein
HCG51_RS22140	COG0123	including yeast histone deacetylase and acetoin utilization protein
HCG51_RS22150	COG0668	transmembrane transport
HCG51_RS22165	COG0683	leucine binding
HCG51_RS22170	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HCG51_RS22190	COG0259	pyridoxamine-phosphate oxidase activity
HCG51_RS22195	COG0628	permease
HCG51_RS22205	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HCG51_RS22210	COG1166	arginine decarboxylase activity
HCG51_RS22215	COG0105	UTP biosynthetic process
HCG51_RS22220	COG0861	Integral membrane protein TerC family
HCG51_RS22225	COG2267	carboxylic ester hydrolase activity
HCG51_RS22240	COG1672	PFAM Archaeal ATPase
HCG51_RS22240	COG2319	Wd-40 repeat
HCG51_RS22255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCG51_RS22260	COG3150	esterase
HCG51_RS22265	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HCG51_RS22295	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HCG51_RS22300	COG3903	Transcriptional regulator
HCG51_RS22300	COG2319	Wd-40 repeat
HCG51_RS22315	COG0163	prenyltransferase activity
HCG51_RS22320	COG0557	exoribonuclease II activity
HCG51_RS22330	COG0740	serine-type endopeptidase activity
HCG51_RS22355	COG1331	Highly conserved protein containing a thioredoxin domain
HCG51_RS22360	COG0746	molybdenum cofactor guanylyltransferase activity
HCG51_RS22370	COG0672	)-iron permease
HCG51_RS22400	COG2132	Multicopper oxidase
HCG51_RS22405	COG0310	cobalt ion transport
HCG51_RS22415	COG1122	ATPase activity
HCG51_RS22435	COG2319	Wd-40 repeat
HCG51_RS22440	COG0574	Belongs to the PEP-utilizing enzyme family
HCG51_RS22440	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HCG51_RS22445	COG1285	pathogenesis
HCG51_RS22455	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HCG51_RS22460	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HCG51_RS22475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HCG51_RS22510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HCG51_RS22515	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HCG51_RS22535	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HCG51_RS22545	COG2131	deaminase
HCG51_RS22555	COG3613	nucleoside 2-deoxyribosyltransferase
HCG51_RS22565	COG0563	adenylate kinase activity
HCG51_RS22570	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HCG51_RS22575	COG0363	glucosamine-6-phosphate deaminase activity
HCG51_RS22580	COG1716	ATPase activity
HCG51_RS22595	COG0222	ribosome binding
HCG51_RS22645	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HCG51_RS22655	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HCG51_RS22680	COG5002	protein histidine kinase activity
HCG51_RS22680	COG2198	Histidine kinase
HCG51_RS22680	COG0784	Response regulator, receiver
HCG51_RS22700	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HCG51_RS22715	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HCG51_RS22720	COG2226	methyltransferase
HCG51_RS22735	COG1058	Belongs to the CinA family
HCG51_RS22735	COG1546	Belongs to the CinA family
HCG51_RS22740	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HCG51_RS22745	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HCG51_RS22760	COG0179	Fumarylacetoacetate (FAA) hydrolase
HCG51_RS22765	COG0360	Binds together with S18 to 16S ribosomal RNA
HCG51_RS22780	COG0586	Pfam SNARE associated Golgi protein
HCG51_RS22785	COG0137	argininosuccinate synthase activity
HCG51_RS22805	COG0612	Peptidase, M16
HCG51_RS22815	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HCG51_RS22820	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_RS22830	COG0678	peroxiredoxin activity
HCG51_RS22835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCG51_RS22845	COG3540	Alkaline phosphatase
HCG51_RS22860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCG51_RS22870	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HCG51_RS22895	COG2197	response regulator
HCG51_RS22910	COG3854	ATPases associated with a variety of cellular activities
HCG51_RS22935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCG51_RS22955	COG0004	ammonium transporteR
HCG51_RS22960	COG1742	UPF0060 membrane protein
HCG51_RS22965	COG0004	ammonium transporteR
HCG51_RS22970	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HCG51_RS22985	COG0589	response to stress
HCG51_RS22985	COG0475	glutathione-regulated potassium exporter activity
HCG51_RS22990	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HCG51_RS23000	COG2363	Small membrane protein
HCG51_RS23025	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HCG51_RS23030	COG2894	cell division
HCG51_RS23035	COG0850	regulation of cytokinetic process
HCG51_RS23050	COG3266	domain, Protein
HCG51_RS23050	COG0515	serine threonine protein kinase
HCG51_RS23095	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HCG51_RS23100	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HCG51_RS23105	COG2211	Major facilitator Superfamily
HCG51_RS23115	COG0028	Belongs to the TPP enzyme family
HCG51_RS23140	COG1028	Short-chain dehydrogenase reductase Sdr
HCG51_RS23150	COG1028	Short-chain dehydrogenase reductase Sdr
HCG51_RS23165	COG4221	oxidoreductase activity
HCG51_RS23180	COG5000	phosphorelay sensor kinase activity
HCG51_RS23185	COG3852	Histidine kinase
HCG51_RS23190	COG3659	wide pore channel activity
HCG51_RS23225	COG0822	iron-sulfur transferase activity
HCG51_RS23250	COG3548	integral membrane protein
HCG51_RS23260	COG1366	Belongs to the anti-sigma-factor antagonist family
HCG51_RS23280	COG2208	phosphoserine phosphatase activity
HCG51_RS23280	COG2770	Histidine kinase
HCG51_RS23310	COG0243	molybdopterin cofactor binding
HCG51_RS23315	COG2223	nitrite transmembrane transporter activity
HCG51_RS23320	COG1116	anion transmembrane transporter activity
HCG51_RS23325	COG1116	anion transmembrane transporter activity
HCG51_RS23325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCG51_RS23330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCG51_RS23335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCG51_RS23385	COG3335	DDE superfamily endonuclease
HCG51_RS23400	COG1214	PFAM Peptidase M22, glycoprotease
HCG51_RS23410	COG0617	tRNA 3'-terminal CCA addition
HCG51_RS23420	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HCG51_RS23425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCG51_RS23435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HCG51_RS23445	COG0515	serine threonine protein kinase
HCG51_RS23450	COG0515	serine threonine protein kinase
HCG51_RS23465	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HCG51_RS23490	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HCG51_RS23505	COG2814	Major facilitator Superfamily
HCG51_RS23515	COG0525	valine-tRNA ligase activity
HCG51_RS23525	COG0435	Glutathione S-transferase
HCG51_RS23535	COG2197	response regulator
HCG51_RS23540	COG3842	ATPase activity
HCG51_RS23560	COG0629	single-stranded DNA binding
HCG51_RS23565	COG4172	Belongs to the ABC transporter superfamily
HCG51_RS23580	COG0752	glycyl-tRNA synthetase alpha subunit
HCG51_RS23615	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HCG51_RS23620	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HCG51_RS23625	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HCG51_RS23625	COG0475	glutathione-regulated potassium exporter activity
HCG51_RS23635	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HCG51_RS23640	COG3852	Histidine kinase
HCG51_RS23645	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HCG51_RS23670	COG4251	negative regulation of phosphorylation
HCG51_RS23670	COG3706	GGDEF domain
HCG51_RS23670	COG5001	Diguanylate cyclase
HCG51_RS23670	COG2203	Gaf domain
HCG51_RS23675	COG2205	protein histidine kinase activity
HCG51_RS23685	COG1131	(ABC) transporter
HCG51_RS23700	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HCG51_RS23710	COG1492	cobalamin metabolic process
HCG51_RS23725	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HCG51_RS23750	COG0316	Belongs to the HesB IscA family
HCG51_RS23765	COG1090	epimerase
HCG51_RS23780	COG2217	Heavy metal translocating P-type atpase
HCG51_RS23855	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HCG51_RS23860	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HCG51_RS23880	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HCG51_RS23885	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HCG51_RS23890	COG0170	dolichyl monophosphate biosynthetic process
HCG51_RS23905	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HCG51_RS23905	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HCG51_RS23910	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HCG51_RS23915	COG0148	phosphopyruvate hydratase activity
HCG51_RS23930	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
HCG51_RS23940	COG0285	dihydrofolate synthase activity
HCG51_RS23965	COG0612	Peptidase, M16
HCG51_RS23975	COG0024	Methionine aminopeptidase
HCG51_RS23985	COG0450	alkyl hydroperoxide reductase
HCG51_RS24000	COG0484	heat shock protein binding
HCG51_RS24010	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HCG51_RS24025	COG1404	Belongs to the peptidase S8 family
HCG51_RS24035	COG0542	response to heat
HCG51_RS24050	COG0515	serine threonine protein kinase
HCG51_RS24055	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HCG51_RS24065	COG1185	polyribonucleotide nucleotidyltransferase activity
HCG51_RS24085	COG4372	Transposase
HCG51_RS24090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCG51_RS24095	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HCG51_RS24100	COG0131	Imidazoleglycerol-phosphate dehydratase
HCG51_RS24105	COG1131	(ABC) transporter
HCG51_RS24110	COG1596	polysaccharide export
HCG51_RS24120	COG0330	HflC and HflK could
HCG51_RS24125	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HCG51_RS24130	COG0149	triose-phosphate isomerase activity
HCG51_RS24135	COG1160	GTP binding
HCG51_RS24155	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HCG51_RS24180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HCG51_RS24185	COG5398	heme oxygenase
HCG51_RS24220	COG0693	protein deglycase activity
HCG51_RS24250	COG3546	catalase activity
HCG51_RS24270	COG1136	(ABC) transporter
HCG51_RS24270	COG0577	efflux transmembrane transporter activity
HCG51_RS24295	COG1032	radical SAM domain protein
HCG51_RS24305	COG0312	modulator of DNA gyrase
HCG51_RS24310	COG0312	modulator of DNA gyrase
HCG51_RS24335	COG1695	Transcriptional regulator
HCG51_RS24350	COG0840	transmembrane signaling receptor activity
HCG51_RS24350	COG2203	Gaf domain
HCG51_RS24355	COG5002	protein histidine kinase activity
HCG51_RS24395	COG0121	glutamine amidotransferase
HCG51_RS24415	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HCG51_RS24420	COG1104	cysteine desulfurase activity
HCG51_RS24465	COG1085	galactose-1-phosphate uridylyltransferase
HCG51_RS24500	COG0798	PFAM Bile acid sodium symporter
HCG51_RS24505	COG0346	lactoylglutathione lyase activity
HCG51_RS24510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HCG51_RS24515	COG1872	DUF167
HCG51_RS24520	COG0625	glutathione transferase activity
HCG51_RS24525	COG2135	peptidase activity
HCG51_RS24530	COG0457	Tetratricopeptide repeat
HCG51_RS24535	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HCG51_RS24540	COG0435	Glutathione S-transferase
HCG51_RS24560	COG1215	transferase activity, transferring glycosyl groups
HCG51_RS24575	COG1519	Transferase
HCG51_RS24575	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HCG51_RS24590	COG3206	protein involved in exopolysaccharide biosynthesis
HCG51_RS24590	COG0489	protein tyrosine kinase activity
HCG51_RS24595	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCG51_RS24605	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HCG51_RS24620	COG1027	Aspartate ammonia-lyase
HCG51_RS24625	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
HCG51_RS24640	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HCG51_RS24645	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HCG51_RS24655	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HCG51_RS24660	COG0583	DNA-binding transcription factor activity
HCG51_RS24670	COG0723	plastoquinol--plastocyanin reductase activity
HCG51_RS24680	COG3210	domain, Protein
HCG51_RS24685	COG1461	Dihydroxyacetone kinase
HCG51_RS24730	COG0322	excinuclease ABC activity
HCG51_RS24735	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCG51_RS24740	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCG51_RS24745	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCG51_RS24750	COG1773	rubredoxin
HCG51_RS24755	COG4447	cellulose binding
HCG51_RS24815	COG4249	Peptidase C14 caspase catalytic subunit p20
HCG51_RS24815	COG2319	Wd-40 repeat
HCG51_RS24835	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HCG51_RS24840	COG0189	ligase activity
HCG51_RS24845	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HCG51_RS24855	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HCG51_RS24865	COG0793	Belongs to the peptidase S41A family
HCG51_RS24870	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HCG51_RS24890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCG51_RS24905	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HCG51_RS24930	COG2197	response regulator
HCG51_RS24935	COG0170	dolichyl monophosphate biosynthetic process
HCG51_RS24945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCG51_RS24950	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HCG51_RS24955	COG0776	regulation of translation
HCG51_RS24960	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_RS24965	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HCG51_RS24970	COG0509	glycine decarboxylation via glycine cleavage system
HCG51_RS24975	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HCG51_RS24975	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HCG51_RS24980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCG51_RS25040	COG2095	MarC family integral membrane protein
HCG51_RS25070	COG0784	Response regulator, receiver
HCG51_RS25070	COG2205	protein histidine kinase activity
HCG51_RS25080	COG1136	(ABC) transporter
HCG51_RS25080	COG0577	efflux transmembrane transporter activity
HCG51_RS25095	COG1309	transcriptional regulator
HCG51_RS25100	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HCG51_RS25120	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HCG51_RS25135	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HCG51_RS25145	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HCG51_RS25150	COG4572	Cation transport regulator
HCG51_RS25155	COG2814	Major facilitator Superfamily
HCG51_RS25175	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HCG51_RS25180	COG1233	COG1233 Phytoene dehydrogenase and related
HCG51_RS25185	COG0515	serine threonine protein kinase
HCG51_RS25185	COG3266	domain, Protein
HCG51_RS25220	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HCG51_RS25220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCG51_RS25230	COG5002	protein histidine kinase activity
HCG51_RS25230	COG2198	Histidine kinase
HCG51_RS25230	COG0784	Response regulator, receiver
HCG51_RS25260	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HCG51_RS25265	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HCG51_RS25305	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HCG51_RS25315	COG0693	protein deglycase activity
HCG51_RS25320	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HCG51_RS25350	COG1215	transferase activity, transferring glycosyl groups
HCG51_RS25395	COG2046	Belongs to the sulfate adenylyltransferase family
HCG51_RS25460	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCG51_RS25500	COG0659	secondary active sulfate transmembrane transporter activity
HCG51_RS25545	COG0175	sulfate reduction
HCG51_RS25555	COG0004	ammonium transporteR
HCG51_RS25560	COG0515	serine threonine protein kinase
HCG51_RS25575	COG0003	Pfam Anion-transporting ATPase
HCG51_RS25580	COG5001	Diguanylate cyclase
HCG51_RS25580	COG4251	negative regulation of phosphorylation
HCG51_RS25580	COG3706	GGDEF domain
HCG51_RS25580	COG2203	Gaf domain
HCG51_RS25580	COG5001	Diguanylate cyclase
HCG51_RS25580	COG4251	negative regulation of phosphorylation
HCG51_RS25580	COG3706	GGDEF domain
HCG51_RS25580	COG2203	Gaf domain
HCG51_RS25585	COG0592	DNA-directed DNA polymerase activity
HCG51_RS25590	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HCG51_RS25605	COG0701	Predicted permease
HCG51_RS25610	COG3852	Histidine kinase
HCG51_RS25625	COG1028	Short-chain dehydrogenase reductase Sdr
HCG51_RS25660	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HCG51_RS25665	COG2885	chlorophyll binding
HCG51_RS25670	COG2885	chlorophyll binding
HCG51_RS25680	COG2066	Belongs to the glutaminase family
HCG51_RS25700	COG0515	serine threonine protein kinase
HCG51_RS25700	COG2815	serine threonine protein kinase
HCG51_RS25705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCG51_RS25715	COG1151	hydroxylamine reductase activity
HCG51_RS25720	COG1034	ATP synthesis coupled electron transport
HCG51_RS25725	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCG51_RS25730	COG3259	Nickel-dependent hydrogenase
HCG51_RS25740	COG1042	CoA-binding domain protein
HCG51_RS25740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCG51_RS25740	COG0045	succinate-CoA ligase (ADP-forming) activity
HCG51_RS25750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCG51_RS25755	COG2124	cytochrome p450
HCG51_RS25760	COG0515	serine threonine protein kinase
HCG51_RS25760	COG2815	serine threonine protein kinase
HCG51_RS25770	COG1489	DNA binding
HCG51_RS25805	COG0484	heat shock protein binding
HCG51_RS25815	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HCG51_RS25820	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HCG51_RS25825	COG0019	diaminopimelate decarboxylase activity
HCG51_RS25830	COG0456	acetyltransferase
HCG51_RS25835	COG0542	response to heat
HCG51_RS25855	COG0681	Belongs to the peptidase S26 family
HCG51_RS25880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCG51_RS25885	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HCG51_RS25890	COG0284	orotidine-5'-phosphate decarboxylase activity
HCG51_RS25900	COG0515	serine threonine protein kinase
HCG51_RS25900	COG2815	serine threonine protein kinase
HCG51_RS25905	COG1028	Short-chain dehydrogenase reductase Sdr
HCG51_RS25915	COG1132	(ABC) transporter
HCG51_RS25920	COG1132	(ABC) transporter
HCG51_RS25930	COG4279	zinc finger
HCG51_RS25945	COG0346	lactoylglutathione lyase activity
HCG51_RS25950	COG0542	response to heat
HCG51_RS25955	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_RS25955	COG0515	serine threonine protein kinase
HCG51_RS25975	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HCG51_RS25985	COG0393	Putative heavy-metal-binding
HCG51_RS26030	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HCG51_RS26035	COG3266	domain, Protein
HCG51_RS26035	COG0515	serine threonine protein kinase
HCG51_RS26040	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HCG51_RS26045	COG1473	amidohydrolase
HCG51_RS26055	COG2376	Dihydroxyacetone kinase
HCG51_RS26070	COG0625	glutathione transferase activity
HCG51_RS26080	COG0242	peptide deformylase activity
HCG51_RS26085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCG51_RS26090	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HCG51_RS26110	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HCG51_RS26125	COG2022	thiamine diphosphate biosynthetic process
HCG51_RS26125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCG51_RS26135	COG1570	exodeoxyribonuclease VII activity
HCG51_RS26140	COG1722	exodeoxyribonuclease VII activity
HCG51_RS26160	COG1562	ergosterol biosynthetic process
HCG51_RS26165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCG51_RS26165	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HCG51_RS26180	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HCG51_RS26215	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HCG51_RS26230	COG0438	transferase activity, transferring glycosyl groups
HCG51_RS26235	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCG51_RS26255	COG0300	oxidoreductase activity
HCG51_RS26275	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HCG51_RS26310	COG1028	Short-chain dehydrogenase reductase Sdr
HCG51_RS26340	COG1040	competence protein
HCG51_RS26350	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HCG51_RS26365	COG0343	queuine tRNA-ribosyltransferase activity
HCG51_RS26385	COG0589	response to stress
HCG51_RS26395	COG2202	Pas domain
HCG51_RS26395	COG2205	protein histidine kinase activity
HCG51_RS26400	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HCG51_RS26400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HCG51_RS26415	COG0596	Alpha beta hydrolase
HCG51_RS26425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCG51_RS26430	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HCG51_RS26440	COG0505	Belongs to the CarA family
HCG51_RS26450	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HCG51_RS26480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HCG51_RS26480	COG0189	ligase activity
HCG51_RS26490	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HCG51_RS26500	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
HCG51_RS26515	COG0047	phosphoribosylformylglycinamidine synthase activity
HCG51_RS26520	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HCG51_RS26525	COG0735	belongs to the Fur family
HCG51_RS26535	COG0330	HflC and HflK could
HCG51_RS26580	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HCG51_RS26585	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HCG51_RS26600	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HCG51_RS26615	COG2226	methyltransferase
HCG51_RS26650	COG0784	Response regulator, receiver
HCG51_RS26650	COG5002	protein histidine kinase activity
HCG51_RS26660	COG0745	RESPONSE REGULATOR receiver
HCG51_RS26665	COG2198	Histidine kinase
HCG51_RS26665	COG0643	Histidine kinase
HCG51_RS26665	COG0784	Response regulator, receiver
HCG51_RS26690	COG2201	protein-glutamate methylesterase activity
HCG51_RS26730	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HCG51_RS26735	COG3659	wide pore channel activity
HCG51_RS26745	COG0525	valine-tRNA ligase activity
HCG51_RS26755	COG2814	Major facilitator Superfamily
HCG51_RS26760	COG2971	BadF BadG BcrA BcrD
HCG51_RS26785	COG1619	proteins homologs of microcin C7 resistance protein MccF
HCG51_RS26790	COG0424	maF-like protein
HCG51_RS26810	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HCG51_RS26830	COG2264	protein methyltransferase activity
HCG51_RS26845	COG0463	Glycosyl transferase, family 2
HCG51_RS26855	COG2814	Major facilitator Superfamily
HCG51_RS26865	COG0315	cyclic pyranopterin monophosphate synthase activity
HCG51_RS26905	COG2226	methyltransferase
HCG51_RS26940	COG1429	ligase activity, forming nitrogen-metal bonds
HCG51_RS27020	COG1028	Short-chain dehydrogenase reductase Sdr
HCG51_RS27025	COG2264	protein methyltransferase activity
HCG51_RS27030	COG0531	amino acid
HCG51_RS27035	COG5002	protein histidine kinase activity
HCG51_RS27050	COG0726	polysaccharide deacetylase
HCG51_RS27065	COG0235	Class ii aldolase
HCG51_RS27070	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HCG51_RS27075	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HCG51_RS27090	COG3507	Belongs to the glycosyl hydrolase 43 family
HCG51_RS27100	COG0205	6-phosphofructokinase activity
HCG51_RS27130	COG2815	serine threonine protein kinase
HCG51_RS27130	COG0515	serine threonine protein kinase
HCG51_RS27135	COG0515	serine threonine protein kinase
HCG51_RS27135	COG2815	serine threonine protein kinase
HCG51_RS27155	COG0156	8-amino-7-oxononanoate synthase activity
HCG51_RS27160	COG0632	four-way junction helicase activity
HCG51_RS27165	COG0561	phosphatase activity
HCG51_RS27170	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HCG51_RS27185	COG3228	Belongs to the MtfA family
HCG51_RS27190	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HCG51_RS27250	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HCG51_RS27270	COG0513	Belongs to the DEAD box helicase family
HCG51_RS27275	COG1032	radical SAM domain protein
HCG51_RS27325	COG1598	PFAM Uncharacterised protein family UPF0150
HCG51_RS27340	COG2373	Large extracellular alpha-helical protein
HCG51_RS27345	COG4953	penicillin-binding protein 1C
HCG51_RS27365	COG0300	oxidoreductase activity
HCG51_RS27400	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HCG51_RS27405	COG1408	metallophosphoesterase
HCG51_RS27410	COG1408	metallophosphoesterase
HCG51_RS27425	COG0730	response to heat
HCG51_RS27440	COG0445	tRNA wobble uridine modification
HCG51_RS27460	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_RS27460	COG0515	serine threonine protein kinase
HCG51_RS27470	COG2149	membrane
HCG51_RS27485	COG0784	Response regulator, receiver
HCG51_RS27490	COG4251	negative regulation of phosphorylation
HCG51_RS27535	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HCG51_RS27550	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HCG51_RS27570	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HCG51_RS27595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HCG51_RS27610	COG5002	protein histidine kinase activity
HCG51_RS27615	COG2201	protein-glutamate methylesterase activity
HCG51_RS27620	COG0643	Histidine kinase
HCG51_RS27620	COG0784	Response regulator, receiver
HCG51_RS27620	COG2198	Histidine kinase
HCG51_RS27620	COG0643	Histidine kinase
HCG51_RS27620	COG2198	Histidine kinase
HCG51_RS27620	COG0784	Response regulator, receiver
HCG51_RS27630	COG0840	transmembrane signaling receptor activity
HCG51_RS27655	COG1252	NADH dehydrogenase
HCG51_RS27675	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HCG51_RS27695	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCG51_RS27700	COG0395	ABC-type sugar transport system, permease component
HCG51_RS27710	COG0303	'Molybdopterin
HCG51_RS27720	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HCG51_RS27725	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HCG51_RS27730	COG0557	exoribonuclease II activity
HCG51_RS27785	COG2319	Wd-40 repeat
HCG51_RS27785	COG1672	PFAM Archaeal ATPase
HCG51_RS27820	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HCG51_RS27840	COG4585	Histidine kinase
HCG51_RS27845	COG2197	response regulator
HCG51_RS27860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCG51_RS27880	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HCG51_RS27880	COG2273	Hydrolase Family 16
HCG51_RS27885	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HCG51_RS27900	COG0363	glucosamine-6-phosphate deaminase activity
HCG51_RS27925	COG0492	ferredoxin-NADP+ reductase activity
HCG51_RS27930	COG0300	oxidoreductase activity
HCG51_RS27940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCG51_RS27945	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCG51_RS27955	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HCG51_RS27985	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HCG51_RS27990	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HCG51_RS28015	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HCG51_RS28020	COG0519	Catalyzes the synthesis of GMP from XMP
HCG51_RS28020	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HCG51_RS28025	COG1230	cation diffusion facilitator family transporter
HCG51_RS28040	COG0436	Aminotransferase
HCG51_RS28045	COG0457	Tetratricopeptide repeat
HCG51_RS28045	COG0463	Glycosyl transferase, family 2
HCG51_RS28070	COG0745	RESPONSE REGULATOR receiver
HCG51_RS28085	COG0606	chelatase, subunit chli
HCG51_RS28090	COG0537	adenosine 5'-monophosphoramidase activity
HCG51_RS28095	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HCG51_RS28100	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HCG51_RS28105	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HCG51_RS28110	COG0735	belongs to the Fur family
HCG51_RS28125	COG2205	protein histidine kinase activity
HCG51_RS28125	COG2202	Pas domain
HCG51_RS28130	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HCG51_RS28135	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HCG51_RS28150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCG51_RS28160	COG2261	transglycosylase associated protein
HCG51_RS28165	COG3237	CsbD-like
HCG51_RS28180	COG4572	Cation transport regulator
HCG51_RS28185	COG0783	Belongs to the Dps family
HCG51_RS28210	COG2205	protein histidine kinase activity
HCG51_RS28210	COG5002	protein histidine kinase activity
HCG51_RS28210	COG0784	Response regulator, receiver
HCG51_RS28245	COG0653	protein targeting
HCG51_RS28275	COG3852	Histidine kinase
HCG51_RS28280	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HCG51_RS28290	COG0322	excinuclease ABC activity
HCG51_RS28300	COG0436	Aminotransferase
HCG51_RS28305	COG3118	belongs to the thioredoxin family
HCG51_RS28310	COG1842	Phage shock protein A
HCG51_RS28315	COG1842	Phage shock protein A
HCG51_RS28380	COG0124	histidyl-tRNA synthetase
HCG51_RS28390	COG0251	oxidation-reduction process
HCG51_RS28400	COG3246	L-lysine catabolic process to acetate
HCG51_RS28420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HCG51_RS28475	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HCG51_RS28490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCG51_RS28495	COG1960	acyl-CoA dehydrogenase activity
HCG51_RS28500	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HCG51_RS28505	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HCG51_RS28520	COG4251	negative regulation of phosphorylation
HCG51_RS28525	COG4999	Histidine kinase
HCG51_RS28525	COG2205	protein histidine kinase activity
HCG51_RS28525	COG3850	Histidine kinase
HCG51_RS28525	COG3437	response regulator, receiver
HCG51_RS28530	COG0515	serine threonine protein kinase
HCG51_RS28530	COG2815	serine threonine protein kinase
HCG51_RS28550	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HCG51_RS28560	COG0018	arginyl-trna synthetase
HCG51_RS28580	COG0438	transferase activity, transferring glycosyl groups
HCG51_RS28610	COG3852	Histidine kinase
HCG51_RS28620	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HCG51_RS28660	COG3344	reverse transcriptase
HCG51_RS28665	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HCG51_RS28735	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HCG51_RS28735	COG0515	serine threonine protein kinase
HCG51_RS28755	COG0784	Response regulator, receiver
HCG51_RS28755	COG2205	protein histidine kinase activity
HCG51_RS28765	COG3000	fatty acid hydroxylase
HCG51_RS28765	COG0300	oxidoreductase activity
HCG51_RS28780	COG0714	Associated with various cellular activities
HCG51_RS28785	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HCG51_RS28805	COG2261	transglycosylase associated protein
HCG51_RS28810	COG3546	catalase activity
HCG51_RS28865	COG4636	protein conserved in cyanobacteria
HCG51_RS28885	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HCG51_RS28890	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HCG51_RS28895	COG0742	ribosomal rna small subunit methyltransferase
HCG51_RS28905	COG2010	Cytochrome c
HCG51_RS28925	COG1132	(ABC) transporter
HCG51_RS28940	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HCG51_RS28945	COG0719	Fe-S assembly protein
HCG51_RS28950	COG0396	ATPase activity
HCG51_RS28955	COG0719	Fe-S assembly protein
HCG51_RS28975	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HCG51_RS28985	COG2197	response regulator
HCG51_RS29000	COG0439	Biotin carboxylase
HCG51_RS29005	COG0762	integral membrane protein
HCG51_RS29015	COG0515	serine threonine protein kinase
HCG51_RS29055	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HCG51_RS29085	COG0463	Glycosyl transferase, family 2
HCG51_RS29090	COG1216	Glycosyl transferase, family 2
HCG51_RS29095	COG1216	Glycosyl transferase, family 2
HCG51_RS29095	COG0463	Glycosyl transferase, family 2
HCG51_RS29265	COG3621	Patatin-like phospholipase
HCG51_RS29280	COG2197	response regulator
HCG51_RS29290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCG51_RS29290	COG2205	protein histidine kinase activity
HCG51_RS29295	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HCG51_RS29300	COG0193	aminoacyl-tRNA hydrolase activity
HCG51_RS29305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HCG51_RS29330	COG0514	ATP-dependent DNA helicase (RecQ)
HCG51_RS29340	COG2208	phosphoserine phosphatase activity
HCG51_RS29345	COG0552	protein localization to endoplasmic reticulum
HCG51_RS29350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HCG51_RS29370	COG0714	Associated with various cellular activities
HCG51_RS29395	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HCG51_RS29475	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HCG51_RS29480	COG0174	glutamine synthetase
HCG51_RS29495	COG1252	NADH dehydrogenase
HCG51_RS29505	COG1957	nucleoside hydrolase
HCG51_RS29515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCG51_RS29540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HCG51_RS29545	COG0110	maltose O-acetyltransferase activity
HCG51_RS29590	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
HCG51_RS29635	COG0515	serine threonine protein kinase
HCG51_RS29635	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HCG51_RS29650	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HCG51_RS29650	COG0515	serine threonine protein kinase
HCG51_RS29660	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HCG51_RS29685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCG51_RS29695	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HCG51_RS29725	COG0210	DNA helicase
HCG51_RS29730	COG2203	Gaf domain
HCG51_RS29730	COG5001	Diguanylate cyclase
HCG51_RS29730	COG4251	negative regulation of phosphorylation
HCG51_RS29730	COG3706	GGDEF domain
HCG51_RS29750	COG0723	plastoquinol--plastocyanin reductase activity
HCG51_RS29760	COG0673	inositol 2-dehydrogenase activity
HCG51_RS29825	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HCG51_RS29830	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HCG51_RS29840	COG0110	maltose O-acetyltransferase activity
HCG51_RS29855	COG0463	Glycosyl transferase, family 2
HCG51_RS29860	COG0438	transferase activity, transferring glycosyl groups
HCG51_RS29875	COG0438	transferase activity, transferring glycosyl groups
HCG51_RS29880	COG0367	asparagine synthase
HCG51_RS29885	COG0297	glycogen (starch) synthase activity
HCG51_RS29905	COG0438	transferase activity, transferring glycosyl groups
HCG51_RS29915	COG0297	glycogen (starch) synthase activity
HCG51_RS29925	COG0438	transferase activity, transferring glycosyl groups
HCG51_RS29930	COG1215	transferase activity, transferring glycosyl groups
HCG51_RS29935	COG0438	transferase activity, transferring glycosyl groups
HCG51_RS29955	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HCG51_RS29960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCG51_RS29980	COG0673	inositol 2-dehydrogenase activity
HCG51_RS30025	COG0489	protein tyrosine kinase activity
HCG51_RS30065	COG1672	PFAM Archaeal ATPase
HCG51_RS30065	COG2319	Wd-40 repeat
HCG51_RS30115	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HCG51_RS30140	COG0848	biopolymer transport protein
HCG51_RS30145	COG0811	peptide transport
HCG51_RS30180	COG5002	protein histidine kinase activity
HCG51_RS30245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCG51_RS30315	COG0728	peptidoglycan biosynthetic process
HCG51_RS30325	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_RS30330	COG1316	TRANSCRIPTIONal
HCG51_RS30340	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HCG51_RS30355	COG2326	polyphosphate kinase activity
HCG51_RS30360	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HCG51_RS30360	COG0574	Belongs to the PEP-utilizing enzyme family
HCG51_RS30365	COG0589	response to stress
HCG51_RS30370	COG0469	pyruvate kinase activity
HCG51_RS30420	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HCG51_RS30425	COG0088	Forms part of the polypeptide exit tunnel
HCG51_RS30430	COG0089	rRNA binding
HCG51_RS30435	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HCG51_RS30440	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HCG51_RS30445	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HCG51_RS30450	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HCG51_RS30460	COG0255	Belongs to the universal ribosomal protein uL29 family
HCG51_RS30465	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HCG51_RS30470	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HCG51_RS30475	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HCG51_RS30480	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HCG51_RS30485	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HCG51_RS30490	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HCG51_RS30495	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HCG51_RS30500	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HCG51_RS30505	COG0200	Binds to the 23S rRNA
HCG51_RS30510	COG0201	protein transport
HCG51_RS30515	COG0563	adenylate kinase activity
HCG51_RS30520	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HCG51_RS30525	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HCG51_RS30530	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HCG51_RS30535	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HCG51_RS30540	COG0202	RNA polymerase activity
HCG51_RS30545	COG0203	ribosomal protein L17
HCG51_RS30550	COG0101	tRNA pseudouridine synthase activity
HCG51_RS30560	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HCG51_RS30565	COG0254	rRNA binding
HCG51_RS30570	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HCG51_RS30585	COG0488	(ABC) transporter
HCG51_RS30590	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HCG51_RS30620	COG0438	transferase activity, transferring glycosyl groups
HCG51_RS30630	COG1381	Involved in DNA repair and RecF pathway recombination
HCG51_RS30635	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HCG51_RS30670	COG0799	negative regulation of ribosome biogenesis
HCG51_RS30675	COG0297	glycogen (starch) synthase activity
HCG51_RS30680	COG1126	abc transporter atp-binding protein
HCG51_RS30685	COG0765	amino acid transport
HCG51_RS30690	COG4597	amino acid ABC transporter
HCG51_RS30695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCG51_RS30710	COG0602	queuosine metabolic process
HCG51_RS30750	COG1049	propionate catabolic process, 2-methylcitrate cycle
HCG51_RS30755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HCG51_RS30765	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HCG51_RS30780	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HCG51_RS30840	COG0438	transferase activity, transferring glycosyl groups
HCG51_RS30850	COG1215	transferase activity, transferring glycosyl groups
HCG51_RS30860	COG0438	transferase activity, transferring glycosyl groups
HCG51_RS30870	COG1192	Involved in chromosome partitioning
HCG51_RS30875	COG1192	Involved in chromosome partitioning
HCG51_RS30880	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HCG51_RS30890	COG0180	Tryptophanyl-tRNA synthetase
HCG51_RS30940	COG1968	undecaprenyl-diphosphatase activity
HCG51_RS30960	COG5001	Diguanylate cyclase
HCG51_RS30980	COG0662	Cupin 2, conserved barrel domain protein
HCG51_RS30980	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HCG51_RS30985	COG1032	radical SAM domain protein
HCG51_RS31005	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HCG51_RS31025	COG1215	transferase activity, transferring glycosyl groups
HCG51_RS31045	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HCG51_RS31060	COG1301	dicarboxylic acid transport
HCG51_RS31065	COG0587	DNA-directed DNA polymerase activity
HCG51_RS31085	COG1028	Short-chain dehydrogenase reductase Sdr
HCG51_RS31100	COG0640	Transcriptional regulator
HCG51_RS31105	COG3118	belongs to the thioredoxin family
HCG51_RS31120	COG0625	glutathione transferase activity
HCG51_RS31145	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HCG51_RS31150	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HCG51_RS31155	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HCG51_RS31160	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HCG51_RS31170	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HCG51_RS31175	COG0356	it plays a direct role in the translocation of protons across the membrane
HCG51_RS31190	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HCG51_RS31215	COG0297	glycogen (starch) synthase activity
HCG51_RS31245	COG0772	Belongs to the SEDS family
HCG51_RS31310	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HCG51_RS31330	COG0459	protein refolding
HCG51_RS31345	COG1028	Short-chain dehydrogenase reductase Sdr
HCG51_RS31360	COG1012	belongs to the aldehyde dehydrogenase family
HCG51_RS31385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCG51_RS31395	COG0415	Belongs to the DNA photolyase family
HCG51_RS31405	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HCG51_RS31410	COG0830	nickel cation binding
HCG51_RS31415	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HCG51_RS31420	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HCG51_RS31440	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HCG51_RS31445	COG3536	Protein conserved in bacteria
HCG51_RS31455	COG0138	bifunctional purine biosynthesis protein purh
HCG51_RS31505	COG4249	Peptidase C14 caspase catalytic subunit p20
HCG51_RS31505	COG2319	Wd-40 repeat
HCG51_RS31530	COG2319	Wd-40 repeat
HCG51_RS31530	COG5635	Nacht domain
HCG51_RS31530	COG5635	Nacht domain
HCG51_RS31530	COG2319	Wd-40 repeat
HCG51_RS31540	COG1672	PFAM Archaeal ATPase
HCG51_RS31540	COG2319	Wd-40 repeat
HCG51_RS31570	COG0739	heme binding
HCG51_RS31580	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HCG51_RS31590	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HCG51_RS31600	COG1285	pathogenesis
HCG51_RS31645	COG0475	glutathione-regulated potassium exporter activity
HCG51_RS31650	COG0475	glutathione-regulated potassium exporter activity
HCG51_RS31680	COG2217	Heavy metal translocating P-type atpase
HCG51_RS31745	COG1116	anion transmembrane transporter activity
HCG51_RS31750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCG51_RS31750	COG1116	anion transmembrane transporter activity
HCG51_RS31755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCG51_RS31760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCG51_RS31790	COG0515	serine threonine protein kinase
HCG51_RS31790	COG3266	domain, Protein
HCG51_RS31800	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HCG51_RS31835	COG0438	transferase activity, transferring glycosyl groups
HCG51_RS31840	COG2045	Belongs to the ComB family
HCG51_RS31885	COG2091	lysine biosynthetic process via aminoadipic acid
HCG51_RS31895	COG0429	hydrolase of the alpha beta-hydrolase fold
HCG51_RS31900	COG0745	RESPONSE REGULATOR receiver
HCG51_RS31905	COG0793	Belongs to the peptidase S41A family
HCG51_RS31910	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HCG51_RS31915	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HCG51_RS31925	COG0438	transferase activity, transferring glycosyl groups
HCG51_RS31935	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HCG51_RS31940	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HCG51_RS31945	COG1959	2 iron, 2 sulfur cluster binding
HCG51_RS31955	COG0038	chloride channel
HCG51_RS31965	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HCG51_RS32000	COG0745	RESPONSE REGULATOR receiver
HCG51_RS32005	COG0784	Response regulator, receiver
HCG51_RS32005	COG2205	protein histidine kinase activity
HCG51_RS32005	COG5002	protein histidine kinase activity
HCG51_RS32055	COG0375	protein maturation
HCG51_RS32060	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HCG51_RS32085	COG4106	trans-aconitate 2-methyltransferase activity
HCG51_RS32115	COG2885	chlorophyll binding
HCG51_RS32205	COG2205	protein histidine kinase activity
HCG51_RS32205	COG2202	Pas domain
HCG51_RS32265	COG1012	belongs to the aldehyde dehydrogenase family
HCG51_RS32285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCG51_RS32300	COG2217	Heavy metal translocating P-type atpase
HCG51_RS32310	COG2223	nitrite transmembrane transporter activity
HCG51_RS32330	COG0405	Gamma-glutamyltransferase
HCG51_RS32345	COG0667	Aldo Keto reductase
HCG51_RS32355	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCG51_RS32360	COG1442	glycosyl transferase family 8
HCG51_RS32360	COG1216	Glycosyl transferase, family 2
HCG51_RS32365	COG2124	cytochrome p450
HCG51_RS32370	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HCG51_RS32445	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HCG51_RS32450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCG51_RS32455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCG51_RS32460	COG2048	Heterodisulfide reductase, subunit B
HCG51_RS32475	COG1528	Iron-storage protein
HCG51_RS32485	COG5002	protein histidine kinase activity
HCG51_RS32485	COG5001	Diguanylate cyclase
HCG51_RS32485	COG3447	MASE1 domain protein
HCG51_RS32490	COG5002	protein histidine kinase activity
HCG51_RS32520	COG0352	thiamine-phosphate diphosphorylase activity
HCG51_RS32525	COG4974	Belongs to the 'phage' integrase family
HCG51_RS32530	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HCG51_RS32535	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HCG51_RS32540	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HCG51_RS32545	COG4208	sulfate ABC transporter
HCG51_RS32555	COG2385	sporulation resulting in formation of a cellular spore
HCG51_RS32590	COG4999	Histidine kinase
HCG51_RS32590	COG3850	Histidine kinase
HCG51_RS32590	COG3437	response regulator, receiver
HCG51_RS32590	COG2205	protein histidine kinase activity
HCG51_RS32600	COG5001	Diguanylate cyclase
HCG51_RS32600	COG2203	Gaf domain
HCG51_RS32600	COG4251	negative regulation of phosphorylation
HCG51_RS32600	COG3706	GGDEF domain
HCG51_RS32615	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HCG51_RS32620	COG0724	RNA recognition motif
HCG51_RS32625	COG1830	Aldolase
HCG51_RS32630	COG4249	Peptidase C14 caspase catalytic subunit p20
HCG51_RS32630	COG2319	Wd-40 repeat
HCG51_RS32655	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HCG51_RS32660	COG5398	heme oxygenase
HCG51_RS32665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HCG51_RS32670	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HCG51_RS32685	COG1028	Short-chain dehydrogenase reductase Sdr
HCG51_RS32690	COG1904	glucuronate isomerase
HCG51_RS32700	COG3265	gluconokinase activity
HCG51_RS32720	COG0358	DNA primase activity
HCG51_RS32770	COG1120	ATPase activity
HCG51_RS32775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCG51_RS32785	COG3659	wide pore channel activity
HCG51_RS32790	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCG51_RS32795	COG1129	ABC transporter
HCG51_RS32800	COG1879	ABC-type sugar transport system periplasmic component
HCG51_RS32805	COG1879	ABC-type sugar transport system periplasmic component
HCG51_RS32865	COG0584	glycerophosphoryl diester phosphodiesterase
HCG51_RS32890	COG2207	Transcriptional regulator
HCG51_RS32890	COG3708	Transcriptional regulator
HCG51_RS32895	COG0667	Aldo Keto reductase
HCG51_RS32900	COG0783	Belongs to the Dps family
HCG51_RS32905	COG1741	Belongs to the pirin family
HCG51_RS32935	COG0109	protoheme IX farnesyltransferase activity
HCG51_RS32955	COG5002	protein histidine kinase activity
HCG51_RS32985	COG1116	anion transmembrane transporter activity
HCG51_RS32990	COG1116	anion transmembrane transporter activity
HCG51_RS32990	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCG51_RS32995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCG51_RS33010	COG0571	ribonuclease III activity
HCG51_RS33030	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HCG51_RS33030	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HCG51_RS33040	COG0670	Belongs to the BI1 family
HCG51_RS33050	COG0318	PFAM AMP-dependent synthetase and ligase
HCG51_RS33055	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HCG51_RS33070	COG0515	serine threonine protein kinase
HCG51_RS33075	COG1196	nuclear chromosome segregation
HCG51_RS33115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCG51_RS33120	COG2274	protein secretion by the type I secretion system
HCG51_RS33130	COG2340	Cysteine-rich secretory protein family
HCG51_RS33175	COG0515	serine threonine protein kinase
HCG51_RS33175	COG3266	domain, Protein
HCG51_RS33190	COG0745	RESPONSE REGULATOR receiver
HCG51_RS33205	COG0783	Belongs to the Dps family
HCG51_RS33215	COG2385	sporulation resulting in formation of a cellular spore
HCG51_RS33225	COG0673	inositol 2-dehydrogenase activity
HCG51_RS33230	COG0024	Methionine aminopeptidase
HCG51_RS33270	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HCG51_RS33305	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HCG51_RS33310	COG1959	2 iron, 2 sulfur cluster binding
HCG51_RS33315	COG1045	serine acetyltransferase
HCG51_RS33325	COG0745	RESPONSE REGULATOR receiver
HCG51_RS33340	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HCG51_RS33345	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HCG51_RS33350	COG0556	nucleotide-excision repair
HCG51_RS33365	COG1361	Conserved repeat domain
HCG51_RS33370	COG4636	protein conserved in cyanobacteria
HCG51_RS33410	COG2205	protein histidine kinase activity
HCG51_RS33410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCG51_RS33420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCG51_RS33425	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HCG51_RS33430	COG0045	succinate-CoA ligase (ADP-forming) activity
HCG51_RS33465	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HCG51_RS33490	COG0456	acetyltransferase
HCG51_RS33505	COG2223	nitrite transmembrane transporter activity
HCG51_RS33520	COG0419	ATPase involved in DNA repair
HCG51_RS33525	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HCG51_RS33535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCG51_RS33555	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HCG51_RS33565	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HCG51_RS33570	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HCG51_RS33620	COG1131	(ABC) transporter
HCG51_RS33635	COG2261	transglycosylase associated protein
HCG51_RS33645	COG5592	hemerythrin HHE cation binding domain
HCG51_RS33655	COG0826	peptidase U32
HCG51_RS33665	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HCG51_RS33670	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HCG51_RS33675	COG5002	protein histidine kinase activity
HCG51_RS33675	COG0784	Response regulator, receiver
HCG51_RS33675	COG2205	protein histidine kinase activity
HCG51_RS33705	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HCG51_RS33725	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HCG51_RS33740	COG0488	(ABC) transporter
HCG51_RS33760	COG1132	(ABC) transporter
HCG51_RS33775	COG2124	cytochrome p450
HCG51_RS33780	COG1192	Involved in chromosome partitioning
HCG51_RS33800	COG0745	RESPONSE REGULATOR receiver
HCG51_RS33805	COG5002	protein histidine kinase activity
HCG51_RS33810	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HCG51_RS33815	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HCG51_RS33825	COG0784	Response regulator, receiver
HCG51_RS33825	COG5002	protein histidine kinase activity
HCG51_RS33825	COG2198	Histidine kinase
HCG51_RS33835	COG0109	protoheme IX farnesyltransferase activity
HCG51_RS33845	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HCG51_RS33850	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HCG51_RS33855	COG1845	cytochrome c oxidase, subunit III
HCG51_RS33860	COG0515	serine threonine protein kinase
HCG51_RS33860	COG3266	domain, Protein
HCG51_RS33935	COG1752	Esterase of the alpha-beta hydrolase superfamily
HCG51_RS33965	COG0484	heat shock protein binding
HCG51_RS33980	COG1475	DNA binding
HCG51_RS33985	COG1192	Involved in chromosome partitioning
HCG51_RS34240	COG0415	Belongs to the DNA photolyase family
HCG51_RS34285	COG1741	Belongs to the pirin family
HCG51_RS34290	COG0667	Aldo Keto reductase
HCG51_RS34295	COG0667	Aldo Keto reductase
HCG51_RS34325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HCG51_RS34415	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HCG51_RS34475	COG1487	ribonuclease activity
HCG51_RS34485	COG0582	viral genome integration into host DNA
HCG51_RS34625	COG5002	protein histidine kinase activity
HCG51_RS34635	COG2217	Heavy metal translocating P-type atpase
HCG51_RS34785	COG0582	viral genome integration into host DNA
HCG51_RS34840	COG1192	Involved in chromosome partitioning
HCG51_RS34845	COG1475	DNA binding
HCG51_RS34870	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HCG51_RS35040	COG1192	Involved in chromosome partitioning
HCG51_RS35055	COG2319	Wd-40 repeat
HCG51_RS35055	COG1672	PFAM Archaeal ATPase
HCG51_RS35065	COG0582	viral genome integration into host DNA
HCG51_RS35195	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCG51_RS35200	COG2340	Cysteine-rich secretory protein family
HCG51_RS35210	COG1192	Involved in chromosome partitioning
HCG51_RS35285	COG1192	Involved in chromosome partitioning
HCG51_RS35290	COG1475	DNA binding