locus-tag class description H4F70_RS00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) H4F70_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) H4F70_RS00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) H4F70_RS00025 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H4F70_RS00040 ENOG4105E5G Alpha beta hydrolase fold H4F70_RS00050 ENOG4107QZF nitrite reductase NADPH large subunit H4F70_RS00055 ENOG4107QZF nitrite reductase NADPH large subunit H4F70_RS00065 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) H4F70_RS00070 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H4F70_RS00110 ENOG4105EUJ GTP cyclohydrolase i H4F70_RS00135 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) H4F70_RS00140 ENOG410814C multidrug resistance protein H4F70_RS00180 ENOG4105DEF Extracellular solute-binding protein, family 5 H4F70_RS00185 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr H4F70_RS00195 ENOG4105D74 hydrolase H4F70_RS00205 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H4F70_RS00235 ENOG4108MTT Glutamate-rich protein grpB H4F70_RS00300 ENOG4105DJ2 Major Facilitator Superfamily H4F70_RS00305 ENOG4107ZR7 Membrane H4F70_RS00370 ENOG4105VBF alkaline shock protein H4F70_RS00410 ENOG4105CH6 catalase H4F70_RS00460 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H4F70_RS00480 ENOG4105MP0 transposase H4F70_RS00500 ENOG4105CSH Transporter H4F70_RS00515 ENOG4105CH6 catalase H4F70_RS00530 ENOG4105E3B Multicopper oxidase H4F70_RS00540 ENOG4105CEY Amp-dependent synthetase and ligase H4F70_RS00545 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) H4F70_RS00555 ENOG4105CEY Amp-dependent synthetase and ligase H4F70_RS00560 ENOG4108JQ7 (ABC) transporter H4F70_RS00585 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) H4F70_RS00595 ENOG4105CHU acetyl-coa acetyltransferase H4F70_RS00600 ENOG4105CMJ mandelate racemase muconate lactonizing H4F70_RS00660 ENOG4108RZE Tetr family transcriptional regulator H4F70_RS00670 ENOG4105CJ1 ABC, transporter H4F70_RS00730 ENOG4105F9F transposase H4F70_RS00735 ENOG4105F9F transposase H4F70_RS00775 ENOG4105CT3 Monooxygenase H4F70_RS00780 ENOG4105DDW LysR family Transcriptional regulator H4F70_RS00785 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) H4F70_RS00810 ENOG4105C3W Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate (By similarity) H4F70_RS00820 ENOG4105CSH Transporter H4F70_RS00825 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) H4F70_RS00835 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component H4F70_RS00840 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component H4F70_RS00845 ENOG4105D7T ABC transporter H4F70_RS00855 ENOG410839S Toxic component of a toxin-antitoxin (TA) module (By similarity) H4F70_RS00865 ENOG4105CPQ Dehydrogenase H4F70_RS00880 ENOG4107HP6 Transcriptional regulator H4F70_RS00885 ENOG4105IKQ hydratase H4F70_RS00890 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) H4F70_RS00895 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) H4F70_RS00905 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) H4F70_RS00915 ENOG4108R3E Dna-3-methyladenine glycosylase i H4F70_RS00920 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) H4F70_RS00930 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) H4F70_RS00960 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) H4F70_RS01005 ENOG4105D9P serine threonine protein kinase H4F70_RS01010 ENOG4107TPY serine threonine protein kinase H4F70_RS01015 ENOG4105CJN penicillin-binding protein H4F70_RS01030 ENOG4105HZM Fha domain containing protein H4F70_RS01035 ENOG4105TV9 FHA Domain-Containing protein H4F70_RS01050 ENOG41061H0 Monooxygenase H4F70_RS01055 ENOG4105CQB FAD linked oxidase domain protein H4F70_RS01075 ENOG4105MC2 DSBA oxidoreductase H4F70_RS01120 ENOG4108IG5 Transcriptional regulator H4F70_RS01125 ENOG4105EBR Carboxylesterase H4F70_RS01135 ENOG4105CAY ferredoxin--nadp reductase H4F70_RS01150 ENOG4106YT9 Enoyl-CoA hydratase H4F70_RS01160 ENOG4105C0R drug resistance transporter emrb qaca subfamily H4F70_RS01170 ENOG4108RM3 Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo H4F70_RS01175 ENOG4105C11 sulfate adenylyltransferase), subunit 2 H4F70_RS01185 ENOG41069M3 Transcriptional regulator H4F70_RS01190 ENOG4105CEY Amp-dependent synthetase and ligase H4F70_RS01195 ENOG4107QX3 carboxylase H4F70_RS01200 ENOG4105VG9 Plasmid stabilization system H4F70_RS01210 ENOG4105DEF Extracellular solute-binding protein, family 5 H4F70_RS01230 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region H4F70_RS01240 ENOG4107RGH Aldehyde dehydrogenase H4F70_RS01275 ENOG4105E39 Enoyl-CoA hydratase H4F70_RS01285 ENOG4105CSH Transporter H4F70_RS01300 ENOG4105CAY ferredoxin--nadp reductase H4F70_RS01320 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) H4F70_RS01335 ENOG4105DXM phenylacetic acid degradation protein H4F70_RS01340 ENOG4105E39 Enoyl-CoA hydratase H4F70_RS01360 ENOG4105CEY Amp-dependent synthetase and ligase H4F70_RS01370 ENOG4107RSM transcriptional regulator H4F70_RS01385 ENOG4105C1G acyl-Coa dehydrogenase H4F70_RS01420 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) H4F70_RS01425 ENOG4105C1G acyl-Coa dehydrogenase H4F70_RS01435 ENOG4105K6S Short-chain dehydrogenase reductase Sdr H4F70_RS01445 ENOG4105C7K acetolactate synthase H4F70_RS01450 ENOG4105D82 Glutamate dehydrogenase H4F70_RS01455 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) H4F70_RS01470 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) H4F70_RS01475 ENOG4105D38 putrescine abc transporter H4F70_RS01480 ENOG4105F38 ABC transporter, permease H4F70_RS01500 ENOG4105JQZ Methyltransferase H4F70_RS01540 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) H4F70_RS01550 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) H4F70_RS01555 ENOG4105EM7 Selenocysteine-specific translation elongation factor H4F70_RS01575 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein H4F70_RS01605 ENOG4105EYF MMPL domain protein H4F70_RS01625 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) H4F70_RS01640 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) H4F70_RS01665 ENOG4105CFN oxalyl-CoA decarboxylase H4F70_RS01675 ENOG4105EWK phytoene H4F70_RS01680 ENOG4105CHR reductase H4F70_RS01695 ENOG4105C1G acyl-Coa dehydrogenase H4F70_RS01705 ENOG4105DTD Dehydrogenase H4F70_RS01735 ENOG4105C1G acyl-Coa dehydrogenase H4F70_RS01740 ENOG4105ETE Transcriptional regulator (LacI family H4F70_RS01745 ENOG4105CBP Major Facilitator H4F70_RS01750 ENOG4105XTG Pfam:DUF156 H4F70_RS01800 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H4F70_RS01805 ENOG4105BZU Histidine kinase H4F70_RS01825 ENOG4107RDP Dehydrogenase H4F70_RS01835 ENOG4105CUB amino acid H4F70_RS01860 ENOG4105WH1 Two component transcriptional regulator luxr family H4F70_RS01865 ENOG4105CDA abc transporter atp-binding protein H4F70_RS01870 ENOG4105E5Q amino acid AbC transporter H4F70_RS01875 ENOG4105MXB limonene-12-epoxide hydrolase H4F70_RS01880 ENOG4106ZX3 phosphonate ABC transporter, periplasmic phosphonate-binding protein H4F70_RS01885 ENOG4105D5T phosphonate abc transporter H4F70_RS01890 ENOG4105S7S phosphonate abc transporter H4F70_RS01905 ENOG4105CPQ Dehydrogenase H4F70_RS01925 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase H4F70_RS01945 ENOG4105MXW flavin reductase domain protein, FMN-binding H4F70_RS02005 ENOG4105EA8 2-Nitropropane dioxygenase H4F70_RS02010 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr H4F70_RS02025 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein H4F70_RS02030 ENOG4105C1G acyl-Coa dehydrogenase H4F70_RS02035 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H4F70_RS02040 ENOG4108HHA Transketolase H4F70_RS02045 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) H4F70_RS02055 ENOG4105CEY Amp-dependent synthetase and ligase H4F70_RS02070 ENOG4107HP6 Transcriptional regulator H4F70_RS02075 ENOG4108RZE Tetr family transcriptional regulator H4F70_RS02080 ENOG4105DMF Dehydrogenase H4F70_RS02085 ENOG4105DEF Extracellular solute-binding protein, family 5 H4F70_RS02090 ENOG4108UQ8 endoribonuclease L-psp H4F70_RS02095 ENOG4105CPC Aldo Keto reductase H4F70_RS02100 ENOG4105H9W Short-chain dehydrogenase reductase Sdr H4F70_RS02105 ENOG41076PI Short-chain dehydrogenase reductase Sdr H4F70_RS02110 ENOG41076PI Short-chain dehydrogenase reductase Sdr H4F70_RS02120 ENOG4105C32 Amino acid ABC transporter (Permease) H4F70_RS02125 ENOG4105C0Z ABC transporter H4F70_RS02130 ENOG4108IV0 ABC, transporter H4F70_RS02140 ENOG4105CHR reductase H4F70_RS02145 ENOG4106HB6 Alpha beta hydrolase H4F70_RS02155 ENOG4107EFR Flavocytochrome c H4F70_RS02180 ENOG4108BAS reductase H4F70_RS02185 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein H4F70_RS02205 ENOG4105CI2 imidazolone-5-propionate hydrolase H4F70_RS02215 ENOG4107S2E monooxygenase H4F70_RS02225 ENOG4105C2C drug resistance transporter, Bcr CflA H4F70_RS02240 ENOG4105HHS UPF0256 protein H4F70_RS02270 ENOG4105KT7 mgtC SapB transporter H4F70_RS02305 ENOG4105D8X mechanosensitive ion channel H4F70_RS02330 ENOG4105ECB domain protein H4F70_RS02340 ENOG4105CVK Glutamate decarboxylase H4F70_RS02360 ENOG4105D7W serine acetyltransferase H4F70_RS02365 ENOG4105CT3 Monooxygenase H4F70_RS02370 ENOG4105CBC glutamate synthase H4F70_RS02385 ENOG410848D S4 domain protein YaaA H4F70_RS02390 ENOG4108JGH Tetr family transcriptional regulator H4F70_RS02395 ENOG4108QIU Dehydrogenase H4F70_RS02400 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H4F70_RS02415 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) H4F70_RS02445 ENOG4107TXC Transcriptional regulator H4F70_RS02450 ENOG4105C26 Dehydrogenase H4F70_RS02465 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) H4F70_RS02535 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) H4F70_RS02540 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) H4F70_RS02550 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) H4F70_RS02555 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone H4F70_RS02560 ENOG41061CK Antibiotic biosynthesis monooxygenase H4F70_RS02565 ENOG4105VFE sira family H4F70_RS02585 ENOG4108KGH TRANSCRIPTIONal H4F70_RS02650 ENOG4105DEF Extracellular solute-binding protein, family 5 H4F70_RS02660 ENOG4105C3U ABC transporter H4F70_RS02675 ENOG41060NJ transcriptional regulator H4F70_RS02680 ENOG4105D2H Uronic isomerase H4F70_RS02685 ENOG4105DEI Mannitol dehydrogenase H4F70_RS02690 ENOG4105CNT hydrolase family 2 H4F70_RS02695 ENOG4105CXK mandelate racemase muconate lactonizing H4F70_RS02700 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family H4F70_RS02740 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) H4F70_RS02770 ENOG4107B57 rieske 2fe-2S domain-containing protein H4F70_RS02780 ENOG410667J hydrolase H4F70_RS02785 ENOG4105JFG SpoIID LytB domain protein H4F70_RS02795 ENOG410602S Transferase H4F70_RS02805 ENOG4106YN8 Prenyltransferase H4F70_RS02810 ENOG4107ISF Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids H4F70_RS02820 ENOG4107YB1 Trehalose corynomycolyl transferase H4F70_RS02840 ENOG4107RCI amp-dependent synthetase and ligase H4F70_RS02850 ENOG4105D8K carboxyl transferase H4F70_RS02865 ENOG4105J1Z Arabinosyltransferase H4F70_RS02870 ENOG4108K7T Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases H4F70_RS02875 ENOG4108RG3 short-chain dehydrogenase reductase H4F70_RS02880 ENOG4105IQ5 FAD linked oxidase domain protein H4F70_RS02890 ENOG410602S Transferase H4F70_RS02900 ENOG4105C26 Dehydrogenase H4F70_RS02910 ENOG4107ZED Uncharacterised protein family UPF0047 H4F70_RS02915 ENOG4108MKI Glycosyl transferase, family 2 H4F70_RS02930 ENOG4108VC7 Protein of unknown function (DUF2587) H4F70_RS02960 ENOG4105CGH 5'-nucleotidase H4F70_RS02965 ENOG4105CIH Imidazole acetol-phosphate transaminase H4F70_RS02995 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) H4F70_RS03000 ENOG4105EVN Prephenate dehydrogenase H4F70_RS03010 ENOG4108Z6B deaminase H4F70_RS03025 ENOG4108HMN Caspase domain H4F70_RS03035 ENOG4105VPX protein, conserved in bacteria H4F70_RS03040 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) H4F70_RS03050 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) H4F70_RS03075 ENOG4105XT2 Transcriptional regulator H4F70_RS03085 ENOG4107UBC ErfK ybiS ycfS ynhG family protein H4F70_RS03090 ENOG4105E6M Sulphatase-modifying factor protein H4F70_RS03125 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) H4F70_RS03135 ENOG4105CHR reductase H4F70_RS03155 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase H4F70_RS03165 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) H4F70_RS03170 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) H4F70_RS03180 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) H4F70_RS03185 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) H4F70_RS03190 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) H4F70_RS03195 ENOG4105CH6 catalase H4F70_RS03205 ENOG4105FG0 Nitroreductase H4F70_RS03210 ENOG4105CFH Aspartokinase H4F70_RS03225 ENOG4105HDK L-asparaginase H4F70_RS03235 ENOG4105EUB pirin domain protein H4F70_RS03240 ENOG4105WKW Pfam:DUF1458 H4F70_RS03245 ENOG41083YR Protein CrcB homolog H4F70_RS03250 ENOG41083TI Protein CrcB homolog H4F70_RS03265 ENOG4105C94 Transporter H4F70_RS03275 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) H4F70_RS03280 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme H4F70_RS03290 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) H4F70_RS03295 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component H4F70_RS03300 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H4F70_RS03330 ENOG4108JQC penicillin-binding protein 1A H4F70_RS03335 ENOG4105N0U Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) H4F70_RS03360 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) H4F70_RS03380 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen H4F70_RS03385 ENOG4105P8F nudix hydrolase H4F70_RS03405 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) H4F70_RS03460 ENOG4108I5C dEAD DEAH box helicase H4F70_RS03475 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) H4F70_RS03520 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase H4F70_RS03525 ENOG4107QPT Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) H4F70_RS03530 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) H4F70_RS03555 ENOG4105DA5 (ABC) transporter H4F70_RS03565 ENOG4105CHU acetyl-coa acetyltransferase H4F70_RS03585 ENOG4108RYC glycosyltransferase H4F70_RS03605 ENOG4105E39 Enoyl-CoA hydratase H4F70_RS03615 ENOG4105C0R drug resistance transporter emrb qaca subfamily H4F70_RS03635 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) H4F70_RS03650 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) H4F70_RS03655 ENOG4105EUJ GTP cyclohydrolase i H4F70_RS03690 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) H4F70_RS03695 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) H4F70_RS03700 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) H4F70_RS03710 ENOG4105CRK lysyL-tRNA synthetase H4F70_RS03735 ENOG4108Z9K Osmotically inducible protein H4F70_RS03755 ENOG4108V9Q carbonic anhydrase H4F70_RS03765 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) H4F70_RS03775 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) H4F70_RS03785 ENOG4108VJ1 Transcriptional regulator (CarD family H4F70_RS03790 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) H4F70_RS03795 ENOG4105C8N cysteinyl-tRNA synthetase H4F70_RS03800 ENOG4105C2N RNA methyltransferase TrmH family group 3 H4F70_RS03805 ENOG4105C1G acyl-Coa dehydrogenase H4F70_RS03820 ENOG4108RH7 phosphoglycerate mutase H4F70_RS03830 ENOG4107QIV Cytochrome c biogenesis protein H4F70_RS03840 ENOG4105CRE cytochrome C H4F70_RS03875 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit H4F70_RS03945 ENOG4107SIQ Naphthoate synthase H4F70_RS03955 ENOG4107TCW O-succinylbenzoate synthase H4F70_RS03970 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) H4F70_RS03980 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) H4F70_RS03985 ENOG4105P52 geranylgeranyl reductase H4F70_RS04005 ENOG4105C94 Transporter H4F70_RS04010 ENOG4108VPT UPF0234 protein H4F70_RS04040 ENOG4108F01 MaoC domain protein H4F70_RS04050 ENOG410683Z Preprotein translocase SecE subunit H4F70_RS04060 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) H4F70_RS04065 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) H4F70_RS04070 ENOG4108VZM 50s ribosomal protein L10 H4F70_RS04075 ENOG41082SK Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) H4F70_RS04140 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) H4F70_RS04145 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) H4F70_RS04160 ENOG4105C0R drug resistance transporter emrb qaca subfamily H4F70_RS04205 ENOG410900P UPF0336 protein H4F70_RS04210 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr H4F70_RS04215 ENOG4105D2B acyl-CoA dehydrogenase H4F70_RS04220 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) H4F70_RS04235 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family H4F70_RS04260 ENOG4105C1G acyl-Coa dehydrogenase H4F70_RS04265 ENOG4107QX3 carboxylase H4F70_RS04285 ENOG4108IG5 Transcriptional regulator H4F70_RS04290 ENOG4105CEY Amp-dependent synthetase and ligase H4F70_RS04290 ENOG4105CEY Amp-dependent synthetase and ligase H4F70_RS04310 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) H4F70_RS04315 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) H4F70_RS04320 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) H4F70_RS04325 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) H4F70_RS04340 ENOG4105CAQ asparagine synthetase H4F70_RS04345 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold H4F70_RS04350 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold H4F70_RS04355 ENOG4105EEF Alkane 1-monooxygenase H4F70_RS04435 ENOG4105VBF alkaline shock protein H4F70_RS04440 ENOG410846T CoA-transferase family III H4F70_RS04455 ENOG4108IUE nitrate reductase beta subunit H4F70_RS04475 ENOG4105MKU Transcriptional regulator H4F70_RS04480 ENOG4108WYP Transcriptional regulator H4F70_RS04485 ENOG4105C1G acyl-Coa dehydrogenase H4F70_RS04505 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) H4F70_RS04515 ENOG4105CEY Amp-dependent synthetase and ligase H4F70_RS04580 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) H4F70_RS04585 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) H4F70_RS04590 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) H4F70_RS04595 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity H4F70_RS04600 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) H4F70_RS04605 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) H4F70_RS04610 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) H4F70_RS04615 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) H4F70_RS04625 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal H4F70_RS04635 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) H4F70_RS04640 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits H4F70_RS04645 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) H4F70_RS04650 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) H4F70_RS04655 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) H4F70_RS04660 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) H4F70_RS04665 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) H4F70_RS04670 ENOG410849U 50S ribosomal protein L30 H4F70_RS04675 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) H4F70_RS04685 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) H4F70_RS04695 ENOG4105VUF Transcriptional regulator H4F70_RS04700 ENOG4105CPC Aldo Keto reductase H4F70_RS04705 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) H4F70_RS04715 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) H4F70_RS04720 ENOG41067V7 50S ribosomal protein L36 H4F70_RS04725 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits H4F70_RS04730 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) H4F70_RS04735 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) H4F70_RS04740 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) H4F70_RS04745 ENOG4108ZT0 50S ribosomal protein l17 H4F70_RS04750 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) H4F70_RS04760 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) H4F70_RS04765 ENOG4108UJD 30S ribosomal protein S9 H4F70_RS04770 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) H4F70_RS04795 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) H4F70_RS04810 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) H4F70_RS04825 ENOG4107BJW polysaccharide deacetylase H4F70_RS04855 ENOG4108IG5 Transcriptional regulator H4F70_RS04875 ENOG41080E2 ribosomal-protein-alanine acetyltransferase H4F70_RS04880 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) H4F70_RS04890 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) H4F70_RS04900 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) H4F70_RS04920 ENOG4108VT4 H4F70_RS04930 ENOG4107QVP Dehydrogenase H4F70_RS04965 ENOG4105WH1 Two component transcriptional regulator luxr family H4F70_RS04970 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase H4F70_RS04975 ENOG4105D9P serine threonine protein kinase H4F70_RS05070 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) H4F70_RS05110 ENOG4105C0B DNA polymerase III (alpha subunit) H4F70_RS05120 ENOG4107RR1 TRANSCRIPTIONal H4F70_RS05130 ENOG4105RHA ABC transporter, permease H4F70_RS05135 ENOG4108IUX (ABC) transporter H4F70_RS05155 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) H4F70_RS05165 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) H4F70_RS05180 ENOG4108IQK o-acetylhomoserine H4F70_RS05190 ENOG4105F27 Major Facilitator H4F70_RS05195 ENOG4105CGK Exodeoxyribonuclease III H4F70_RS05210 ENOG41080XP Cbs domain H4F70_RS05215 ENOG4105C31 Tryptophanyl-tRNA synthetase H4F70_RS05220 ENOG4107H3J ribonuclease H4F70_RS05225 ENOG4105CQB FAD linked oxidase domain protein H4F70_RS05270 ENOG4107QM5 aconitate hydratase H4F70_RS05275 ENOG4105E33 succinate dehydrogenase H4F70_RS05280 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) H4F70_RS05305 ENOG4108CCU Ribonucleotide-diphosphate reductase subunit beta H4F70_RS05310 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) H4F70_RS05325 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) H4F70_RS05345 ENOG4107RM1 amidohydrolase H4F70_RS05360 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) H4F70_RS05385 ENOG4108JIK carboxylase H4F70_RS05410 ENOG4107WR6 Maf-like protein H4F70_RS05420 ENOG4105D8K carboxyl transferase H4F70_RS05445 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit H4F70_RS05450 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) H4F70_RS05470 ENOG4105CQB FAD linked oxidase domain protein H4F70_RS05490 ENOG4107TB5 TRANSCRIPTIONal H4F70_RS05520 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) H4F70_RS05525 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) H4F70_RS05540 ENOG4107QKV phosphomannomutase H4F70_RS05545 ENOG4105W49 UPF0434 protein H4F70_RS05555 ENOG4105EIP mannose-6-phosphate isomerase H4F70_RS05565 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) H4F70_RS05595 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H4F70_RS05600 ENOG4105BZU Histidine kinase H4F70_RS05605 ENOG4108MKR lipoprotein lpqb H4F70_RS05615 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea H4F70_RS05620 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving H4F70_RS05680 ENOG4105DYW oxidoreductase H4F70_RS05715 ENOG4105E39 Enoyl-CoA hydratase H4F70_RS05755 ENOG4108KC2 acyl-Coa dehydrogenase H4F70_RS05760 ENOG4105X7H acyl-CoA dehydrogenase H4F70_RS05770 ENOG4105CY3 ABC transporter, permease H4F70_RS05820 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase H4F70_RS05845 ENOG4108UQY Iron-storage protein H4F70_RS05860 ENOG4107ZUX Histidine triad (HIT) protein H4F70_RS05865 ENOG4105C12 Phosphoribosylglycinamide synthetase H4F70_RS05870 ENOG4105CHM Aminotransferase H4F70_RS05880 ENOG4105C83 adenylosuccinate lyase H4F70_RS05885 ENOG4105C8V SAICAR synthetase H4F70_RS05900 ENOG4105F4R Transcriptional regulator mode H4F70_RS05905 ENOG4108V06 Glutathione peroxidase H4F70_RS05915 ENOG410839H phosphoribosylformylglycinamidine synthase H4F70_RS05920 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I H4F70_RS05935 ENOG4105DFM M18 family aminopeptidase H4F70_RS05940 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii H4F70_RS05965 ENOG4105CXB phosphoribosylaminoimidazole synthetase H4F70_RS05975 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) H4F70_RS05985 ENOG41064MX Tetr family transcriptional regulator H4F70_RS05990 ENOG4108SVG May play a role in the intracellular transport of hydrophobic ligands H4F70_RS05995 ENOG4105PKJ carbohydrate binding H4F70_RS06000 ENOG4105KHC sulfurtransferase H4F70_RS06020 ENOG4107NHD transcriptional regulator H4F70_RS06025 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) H4F70_RS06030 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) H4F70_RS06045 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) H4F70_RS06065 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) H4F70_RS06080 ENOG4105J5T Amp-dependent synthetase and ligase H4F70_RS06210 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) H4F70_RS06425 ENOG4105FA0 parb-like partition protein H4F70_RS06495 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) H4F70_RS06510 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) H4F70_RS06605 ENOG4105NVB glycoside hydrolase, family 19 H4F70_RS06685 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H4F70_RS06720 ENOG4105E5Q amino acid AbC transporter H4F70_RS06735 ENOG4105C0R drug resistance transporter emrb qaca subfamily H4F70_RS06750 ENOG4105CEY Amp-dependent synthetase and ligase H4F70_RS06755 ENOG4107QX3 carboxylase H4F70_RS06765 ENOG4105C1G acyl-Coa dehydrogenase H4F70_RS06770 ENOG4105DJG MaoC domain protein dehydratase H4F70_RS06795 ENOG41061TZ Short-chain dehydrogenase reductase Sdr H4F70_RS06800 ENOG4105CHR reductase H4F70_RS06810 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) H4F70_RS06850 ENOG4108SGK Tetr family transcriptional regulator H4F70_RS06870 ENOG4105J5T Amp-dependent synthetase and ligase H4F70_RS06875 ENOG4105CEY Amp-dependent synthetase and ligase H4F70_RS06885 ENOG4105J5T Amp-dependent synthetase and ligase H4F70_RS06895 ENOG4107ZQV short-chain dehydrogenase reductase H4F70_RS06905 ENOG4105C26 Dehydrogenase H4F70_RS06910 ENOG4105C1G acyl-Coa dehydrogenase H4F70_RS06925 ENOG4108Z0R Transferase H4F70_RS06965 ENOG41067TZ transcriptional regulator, MarR family H4F70_RS06975 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) H4F70_RS06995 ENOG4105WH1 Two component transcriptional regulator luxr family H4F70_RS07020 ENOG4105XDV H4F70_RS07055 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H4F70_RS07070 ENOG4107RR1 TRANSCRIPTIONal H4F70_RS07075 ENOG4105C26 Dehydrogenase H4F70_RS07100 ENOG4108ZX5 transcriptional regulator H4F70_RS07105 ENOG4105C1G acyl-Coa dehydrogenase H4F70_RS07110 ENOG410846T CoA-transferase family III H4F70_RS07120 ENOG4105CHU acetyl-coa acetyltransferase H4F70_RS07125 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase H4F70_RS07170 ENOG4105F95 Monooxygenase H4F70_RS07180 ENOG4105CFI type iii restriction protein res subunit H4F70_RS07255 ENOG4108N0W Major Facilitator superfamily H4F70_RS07275 ENOG4105C7N Xanthine uracil vitamin C permease H4F70_RS07300 ENOG4105C1G acyl-Coa dehydrogenase H4F70_RS07310 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) H4F70_RS07325 ENOG41081K0 peptidylprolyl cis-trans isomerase H4F70_RS07340 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) H4F70_RS07355 ENOG4108YZ9 Urea amidohydrolase subunit gamma H4F70_RS07360 ENOG4105KI2 Urea amidohydrolase subunit beta H4F70_RS07365 ENOG4105CQM Urea amidohydrolase subunit alpha H4F70_RS07375 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) H4F70_RS07380 ENOG4105MT3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) H4F70_RS07385 ENOG4108JQ6 ABC transporter H4F70_RS07390 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H4F70_RS07420 ENOG4105C94 Transporter H4F70_RS07425 ENOG4105DGI Alkaline phosphatase H4F70_RS07455 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) H4F70_RS07475 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic H4F70_RS07490 ENOG4107Z67 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) H4F70_RS07500 ENOG4105EBR Carboxylesterase H4F70_RS07520 ENOG4105D7N magnesium and cobalt transport protein CorA H4F70_RS07540 ENOG4108Z6Z Transcriptional regulator H4F70_RS07640 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase H4F70_RS07650 ENOG4107YXZ hydrolase, family 25 H4F70_RS07665 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) H4F70_RS07675 ENOG4107QP8 phosphohexose isomerase H4F70_RS07705 ENOG4105DR5 peptidase H4F70_RS07710 ENOG4105CMV Succinyl-CoA synthetase subunit beta H4F70_RS07745 ENOG4105EET magnesium chelatase H4F70_RS07760 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) H4F70_RS07765 ENOG4105EN6 Membrane H4F70_RS07770 ENOG4105ETX regulatoR H4F70_RS07775 ENOG41062D9 Histidine kinase H4F70_RS07785 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) H4F70_RS07805 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase H4F70_RS07810 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase H4F70_RS07820 ENOG4105D9U N-acetyltransferase H4F70_RS07870 ENOG4107ZQV short-chain dehydrogenase reductase H4F70_RS07930 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) H4F70_RS07935 ENOG4105F8V Hydrolase, tatD family H4F70_RS07940 ENOG4106839 domain protein H4F70_RS07950 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) H4F70_RS07960 ENOG4105E39 Enoyl-CoA hydratase H4F70_RS07970 ENOG4105FDF Could be involved in DNA repair (By similarity) H4F70_RS07980 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) H4F70_RS07985 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) H4F70_RS07990 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) H4F70_RS08000 ENOG4105K89 arsenate reductase H4F70_RS08020 ENOG4108V75 Glutamine amidotransferase H4F70_RS08025 ENOG41067HS methyltransferase H4F70_RS08050 ENOG4105FDP GntR family transcriptional regulator H4F70_RS08055 ENOG4105DKW ABC transporter H4F70_RS08075 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) H4F70_RS08100 ENOG41082JN Transcriptional regulator H4F70_RS08110 ENOG4105DXN mazG family H4F70_RS08125 ENOG4105E2B Taurine dioxygenase H4F70_RS08135 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) H4F70_RS08180 ENOG4105MP0 transposase H4F70_RS08220 ENOG4108RAV Conserved protein H4F70_RS08230 ENOG4105CHU acetyl-coa acetyltransferase H4F70_RS08240 ENOG4108UAJ Transcriptional regulator H4F70_RS08265 ENOG4107RN6 Monooxygenase H4F70_RS08275 ENOG4105CIG ABC transporter H4F70_RS08280 ENOG4105DIM ABC transporter H4F70_RS08300 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) H4F70_RS08305 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving H4F70_RS08355 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) H4F70_RS08365 ENOG4105T1M mycothiol conjugate amidase mca H4F70_RS08370 ENOG4105C7Z Conserved Protein H4F70_RS08390 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) H4F70_RS08400 ENOG4105CPQ Dehydrogenase H4F70_RS08420 ENOG4105CS9 pantothenic acid kinase H4F70_RS08430 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) H4F70_RS08450 ENOG4108IAB Phoh family H4F70_RS08465 ENOG4108RM3 Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo H4F70_RS08530 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) H4F70_RS08545 ENOG4107RFY SbcCD D subunit H4F70_RS08550 ENOG4105EYH Exonuclease H4F70_RS08555 ENOG4105C02 permease H4F70_RS08565 ENOG4105C3G gtp-binding protein H4F70_RS08570 ENOG4105D5G Transposase H4F70_RS08650 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) H4F70_RS08655 ENOG4105DXI Major Facilitator superfamily H4F70_RS08700 ENOG4105IDI abc transporter atp-binding protein H4F70_RS08715 ENOG4105CSV Glutaminase H4F70_RS08730 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H4F70_RS08740 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H4F70_RS08750 ENOG4108IEH NADH dehydrogenase subunit g H4F70_RS08755 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) H4F70_RS08760 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H4F70_RS08765 ENOG4105DF2 NADH dehydrogenase subunit j H4F70_RS08785 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H4F70_RS08795 ENOG4108QB1 triacylglycerol lipase EC 3.1.1.3 H4F70_RS08805 ENOG4107GFK fumarate H4F70_RS08850 ENOG410842T Pterin carbinolamine dehydratase H4F70_RS08865 ENOG4108UCS ABC, transporter H4F70_RS08870 ENOG4105CI3 gtp-binding protein typa H4F70_RS08875 ENOG4107USK Extracellular solute-binding protein, family 5 H4F70_RS08880 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) H4F70_RS08900 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) H4F70_RS08905 ENOG4108Z4U Ferredoxin H4F70_RS08920 ENOG4105CEY Amp-dependent synthetase and ligase H4F70_RS08925 ENOG410905P Pyridoxamine 5-phosphate H4F70_RS08930 ENOG4105M2Z protein tyrosine serine phosphatase H4F70_RS08945 ENOG4108JGH Tetr family transcriptional regulator H4F70_RS08955 ENOG4105C85 amino acid H4F70_RS08965 ENOG4107R4C succinyl-diaminopimelate desuccinylase H4F70_RS08975 ENOG4108URH decarboxylase H4F70_RS08980 ENOG4105EEI dihydropteroate synthase H4F70_RS08985 ENOG4105C3Q Glycosyl transferase, family 2 H4F70_RS09005 ENOG4107ZBN O-methyltransferase H4F70_RS09015 ENOG4105C0H protease H4F70_RS09040 ENOG4105CJW magnesium transporter H4F70_RS09055 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) H4F70_RS09065 ENOG4105DB7 PHP domain protein H4F70_RS09095 ENOG4107RN6 Monooxygenase H4F70_RS09100 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) H4F70_RS09105 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 H4F70_RS09110 ENOG4105BZ1 (ABC) transporter H4F70_RS09160 ENOG4105CC9 acyl-Coa dehydrogenase H4F70_RS09165 ENOG4105C1G acyl-Coa dehydrogenase H4F70_RS09180 ENOG4105EBR Carboxylesterase H4F70_RS09185 ENOG4108WKN secreted protein H4F70_RS09215 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) H4F70_RS09220 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) H4F70_RS09225 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) H4F70_RS09230 ENOG4105C0R drug resistance transporter emrb qaca subfamily H4F70_RS09240 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 H4F70_RS09245 ENOG4105CPP Dehydrogenase, E1 component H4F70_RS09270 ENOG4105C0D helicase H4F70_RS09275 ENOG4107XWB Zinc finger, swim domain protein H4F70_RS09280 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) H4F70_RS09295 ENOG4105C75 arginyL-tRNA synthetase H4F70_RS09300 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) H4F70_RS09305 ENOG4105D6E homoserine dehydrogenase H4F70_RS09310 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) H4F70_RS09315 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) H4F70_RS09320 ENOG4105CEY Amp-dependent synthetase and ligase H4F70_RS09330 ENOG4105VFB Binds the 23S rRNA (By similarity) H4F70_RS09335 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) H4F70_RS09340 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) H4F70_RS09360 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) H4F70_RS09365 ENOG4105ZA1 atp synthase H4F70_RS09370 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) H4F70_RS09375 ENOG4108SBS F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) H4F70_RS09380 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) H4F70_RS09385 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) H4F70_RS09390 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) H4F70_RS09395 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) H4F70_RS09435 ENOG4105DSU hydrolase H4F70_RS09450 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) H4F70_RS09470 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) H4F70_RS09490 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) H4F70_RS09495 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) H4F70_RS09505 ENOG4105CAT Cytidine monophosphate kinase H4F70_RS09510 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) H4F70_RS09520 ENOG4105P8F nudix hydrolase H4F70_RS09525 ENOG4107R37 Glutamate dehydrogenase H4F70_RS09555 ENOG4108UW8 fha domain-containing protein H4F70_RS09585 ENOG4107UAX integral membrane protein H4F70_RS09600 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) H4F70_RS09620 ENOG4105CEP NADH dehydrogenase H4F70_RS09665 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein H4F70_RS09670 ENOG4105E2B Taurine dioxygenase H4F70_RS09690 ENOG4105CEY Amp-dependent synthetase and ligase H4F70_RS09705 ENOG4105DIA mandelate racemase muconate lactonizing H4F70_RS09750 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) H4F70_RS09765 ENOG4105CQB FAD linked oxidase domain protein H4F70_RS09775 ENOG4105C54 Major Facilitator superfamily H4F70_RS09785 ENOG4105E1F short-chain dehydrogenase reductase H4F70_RS09830 ENOG4105CH6 catalase H4F70_RS09845 ENOG4105CYX Short-chain dehydrogenase reductase Sdr H4F70_RS09850 ENOG4105EV8 ectoine hydroxylase H4F70_RS09860 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase H4F70_RS09925 ENOG4105C6Y Udp-glucose 6-dehydrogenase H4F70_RS09970 ENOG4105C26 Dehydrogenase H4F70_RS09980 ENOG4107QRI Phosphoketolase H4F70_RS09985 ENOG4107R7Y intracellular protease Pfpi family H4F70_RS10005 ENOG4105Q70 H4F70_RS10020 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) H4F70_RS10045 ENOG4105CBC glutamate synthase H4F70_RS10050 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) H4F70_RS10075 ENOG4105CJW magnesium transporter H4F70_RS10095 ENOG4105DEN Luciferase family H4F70_RS10100 ENOG4108RG3 short-chain dehydrogenase reductase H4F70_RS10140 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) H4F70_RS10155 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) H4F70_RS10165 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) H4F70_RS10175 ENOG4105E5F proteasome H4F70_RS10180 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) H4F70_RS10200 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) H4F70_RS10210 ENOG4105C3R Methionine synthase H4F70_RS10220 ENOG4105C8N cysteinyl-tRNA synthetase H4F70_RS10240 ENOG4105CPC Aldo Keto reductase H4F70_RS10255 ENOG4107R4I Periplasmic binding protein H4F70_RS10260 ENOG4105EHG Permease protein H4F70_RS10265 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) H4F70_RS10290 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) H4F70_RS10305 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) H4F70_RS10365 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) H4F70_RS10370 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH H4F70_RS10375 ENOG4105CHR reductase H4F70_RS10390 ENOG4105C7R Atpase associated with various cellular activities aaa_3 H4F70_RS10395 ENOG4105ZXU NLP P60 protein H4F70_RS10405 ENOG4107QM5 aconitate hydratase H4F70_RS10410 ENOG4108Q5F Tetr family transcriptional regulator H4F70_RS10415 ENOG4105C5H ABC transporter H4F70_RS10420 ENOG4105CHR reductase H4F70_RS10425 ENOG4108JT6 LycopEne H4F70_RS10440 ENOG4105VG1 fes assembly suf system protein H4F70_RS10445 ENOG4108UNV SUF system FeS assembly protein, NifU family H4F70_RS10455 ENOG4105C3K feS assembly ATPase SufC H4F70_RS10475 ENOG4107JC6 Membrane H4F70_RS10480 ENOG4105CJ1 ABC, transporter H4F70_RS10495 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein H4F70_RS10500 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) H4F70_RS10510 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) H4F70_RS10540 ENOG4105CP7 Triose-phosphate isomerase H4F70_RS10545 ENOG4105BZA Phosphoglycerate kinase H4F70_RS10550 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase H4F70_RS10555 ENOG4105CIE May be required for sporulation (By similarity) H4F70_RS10585 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) H4F70_RS10610 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) H4F70_RS10625 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP H4F70_RS10640 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) H4F70_RS10665 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain H4F70_RS10680 ENOG4105CXT aspartate transcarbamylase H4F70_RS10685 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) H4F70_RS10690 ENOG410803B Involved in the transcription termination process (By similarity) H4F70_RS10695 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) H4F70_RS10700 ENOG4105DC7 peptidase M24 H4F70_RS10715 ENOG4105D49 3-dehydroquinate synthase H4F70_RS10725 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase H4F70_RS10735 ENOG4105E2X shikimate dehydrogenase H4F70_RS10740 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) H4F70_RS10745 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) H4F70_RS10760 ENOG4105C9M aspartyl-trna synthetase H4F70_RS10775 ENOG4105C7K acetolactate synthase H4F70_RS10780 ENOG4105CMT Dihydroxyacetone kinase H4F70_RS10800 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) H4F70_RS10840 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) H4F70_RS10855 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) H4F70_RS10860 ENOG4108QB1 triacylglycerol lipase EC 3.1.1.3 H4F70_RS10880 ENOG4105CJQ hydrolase, family 31 H4F70_RS10890 ENOG4105C87 Aminotransferase class I and II H4F70_RS10910 ENOG4107WA4 MmpL domain-containing protein H4F70_RS10920 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) H4F70_RS10975 ENOG4105CEY Amp-dependent synthetase and ligase H4F70_RS10985 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving H4F70_RS10995 ENOG4105CSH Transporter H4F70_RS11005 ENOG4107QJE Chromosome Partitioning Protein H4F70_RS11040 ENOG4105F9F transposase H4F70_RS11100 ENOG4105CG3 alpha amylase, catalytic region H4F70_RS11110 ENOG4107QK4 glycoside hydrolase, family 3 domain protein H4F70_RS11135 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) H4F70_RS11140 ENOG4105J5T Amp-dependent synthetase and ligase H4F70_RS11145 ENOG4108IG5 Transcriptional regulator H4F70_RS11160 ENOG4107STQ Multicopper oxidase H4F70_RS11190 ENOG4105CGU Enoyl-CoA hydratase H4F70_RS11195 ENOG4105CEY Amp-dependent synthetase and ligase H4F70_RS11210 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F H4F70_RS11225 ENOG4105CEY Amp-dependent synthetase and ligase H4F70_RS11230 ENOG4105DV0 amidase (EC 3.5.1.4 H4F70_RS11235 ENOG4108Z5V transcriptional regulator, merr family H4F70_RS11260 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) H4F70_RS11275 ENOG4105F2C Acetyl-CoA acetyltransferase H4F70_RS11285 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase H4F70_RS11290 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase H4F70_RS11295 ENOG4105MP9 class II Aldolase H4F70_RS11305 ENOG4105CEY Amp-dependent synthetase and ligase H4F70_RS11325 ENOG4105X7H acyl-CoA dehydrogenase H4F70_RS11340 ENOG4105YIP Tetr family transcriptional regulator H4F70_RS11345 ENOG4105DYW oxidoreductase H4F70_RS11365 ENOG4108XG2 Histidine kinase H4F70_RS11425 ENOG4107QUV Domain protein H4F70_RS11435 ENOG4108ZHR arsR family transcriptional regulator H4F70_RS11445 ENOG41086VY Fic/DOC family H4F70_RS11455 ENOG4107SCA Formamidase (EC 3.5.1.49) H4F70_RS11465 ENOG4105E39 Enoyl-CoA hydratase H4F70_RS11470 ENOG4105CEY Amp-dependent synthetase and ligase H4F70_RS11500 ENOG4105CUT histidyl-tRNA synthetase H4F70_RS11505 ENOG4107VMB Beta-lactamase domain protein H4F70_RS11515 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) H4F70_RS11525 ENOG4108NY6 Extracellular solute-binding protein, family 5 H4F70_RS11530 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) H4F70_RS11545 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) H4F70_RS11550 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) H4F70_RS11555 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) H4F70_RS11560 ENOG4105CDY transcriptional regulatory protein H4F70_RS11565 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) H4F70_RS11570 ENOG4105C29 acyl-CoA thioesterase H4F70_RS11575 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) H4F70_RS11580 ENOG41062IR nudix hydrolase H4F70_RS11585 ENOG4105E2K Glycosyl transferase (Group 1 H4F70_RS11590 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase H4F70_RS11605 ENOG4105C22 threonyL-tRNA synthetase H4F70_RS11650 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) H4F70_RS11665 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family H4F70_RS11710 ENOG4108P2G integral membrane protein H4F70_RS11715 ENOG4105E0X reductase H4F70_RS11720 ENOG4107JTW chlorite dismutase H4F70_RS11725 ENOG4105C1Q protoporphyrinogen oxidase H4F70_RS11730 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) H4F70_RS11755 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) H4F70_RS11760 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) H4F70_RS11765 ENOG4105C0X amino acid H4F70_RS11770 ENOG4107VEG TrkA-N domain protein H4F70_RS11800 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) H4F70_RS11835 ENOG4107S91 Sodium hydrogen exchanger H4F70_RS11885 ENOG4105DGU Histone deacetylase H4F70_RS11945 ENOG4105C5Q Transcriptional regulator H4F70_RS11950 ENOG4105D3R alkyl hydroperoxide reductase H4F70_RS11955 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) H4F70_RS11970 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator H4F70_RS11975 ENOG4105C2J ABC transporter H4F70_RS11980 ENOG4108RVA ribokinase H4F70_RS11985 ENOG4105CQ7 ATP-dependent helicase H4F70_RS11990 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) H4F70_RS12010 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) H4F70_RS12015 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) H4F70_RS12020 ENOG4107QP3 malate synthase g H4F70_RS12025 ENOG41069M3 Transcriptional regulator H4F70_RS12030 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) H4F70_RS12040 ENOG4105C99 atpase involved in dna repair H4F70_RS12050 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) H4F70_RS12055 ENOG4105CDA abc transporter atp-binding protein H4F70_RS12060 ENOG4107UBR Extracellular solute-binding protein family 3 H4F70_RS12065 ENOG4108Q1T ABC transporter H4F70_RS12075 ENOG4105KC9 Modulates RecA activity (By similarity) H4F70_RS12080 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) H4F70_RS12100 ENOG4107ZYJ bioY protein H4F70_RS12105 ENOG4108JJB ABC transporter H4F70_RS12110 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) H4F70_RS12120 ENOG4105WBV Transcriptional regulator H4F70_RS12155 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) H4F70_RS12160 ENOG4107SMJ Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) H4F70_RS12180 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) H4F70_RS12190 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) H4F70_RS12195 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) H4F70_RS12210 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) H4F70_RS12225 ENOG4107QI1 Mate efflux family protein H4F70_RS12230 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) H4F70_RS12250 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) H4F70_RS12265 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) H4F70_RS12270 ENOG4107XFJ UPF0246 protein H4F70_RS12275 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) H4F70_RS12280 ENOG4105DWT malate dehydrogenase (quinone) H4F70_RS12320 ENOG4105CJN penicillin-binding protein H4F70_RS12330 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) H4F70_RS12340 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) H4F70_RS12345 ENOG41068X0 Protein of unknown function (DUF2631) H4F70_RS12350 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs H4F70_RS12355 ENOG41060H3 Protein of unknown function (DUF1049) H4F70_RS12365 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) H4F70_RS12370 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) H4F70_RS12375 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) H4F70_RS12380 ENOG4105CE9 30S ribosomal protein S2 H4F70_RS12390 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H4F70_RS12410 ENOG41080R2 UPF0102 protein H4F70_RS12420 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) H4F70_RS12425 ENOG4107QYR Signal peptidase i H4F70_RS12430 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) H4F70_RS12435 ENOG4105BZM domain protein H4F70_RS12440 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) H4F70_RS12445 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) H4F70_RS12455 ENOG4105K5M 30s ribosomal protein S16 H4F70_RS12495 ENOG4108375 Acylphosphatase (EC 3.6.1.7) H4F70_RS12520 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) H4F70_RS12525 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) H4F70_RS12545 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) H4F70_RS12550 ENOG4106H78 methyltransferase H4F70_RS12555 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) H4F70_RS12560 ENOG4105CB5 ATP-dependent DNA helicase recG H4F70_RS12565 ENOG4105DP4 dak2 domain fusion protein ylov H4F70_RS12570 ENOG4105VB9 50S ribosomal protein l28 H4F70_RS12575 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) H4F70_RS12595 ENOG4105CPF Cell wall formation (By similarity) H4F70_RS12600 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase H4F70_RS12610 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) H4F70_RS12625 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) H4F70_RS12630 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) H4F70_RS12650 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) H4F70_RS12655 ENOG4105CEY Amp-dependent synthetase and ligase H4F70_RS12660 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase H4F70_RS12665 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) H4F70_RS12680 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase H4F70_RS12685 ENOG4108ZP8 Acetolactate synthase small subunit H4F70_RS12700 ENOG4105C01 Dihydroxy-acid dehydratase H4F70_RS12715 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) H4F70_RS12730 ENOG4105WH1 Two component transcriptional regulator luxr family H4F70_RS12735 ENOG4105BZU Histidine kinase H4F70_RS12750 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) H4F70_RS12755 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) H4F70_RS12765 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) H4F70_RS12785 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) H4F70_RS12795 ENOG4105C10 Electron transfer flavoprotein H4F70_RS12805 ENOG4108KQJ Type 11 methyltransferase H4F70_RS12825 ENOG4105EVB acetyltransferase H4F70_RS12855 ENOG4105DKW ABC transporter H4F70_RS12860 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) H4F70_RS12880 ENOG4105CHU acetyl-coa acetyltransferase H4F70_RS12925 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) H4F70_RS12930 ENOG4108UVJ appr-1-p processing domain protein H4F70_RS12970 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) H4F70_RS12985 ENOG4105CH7 arginosuccinase H4F70_RS12990 ENOG4105CDH Citrulline--aspartate ligase H4F70_RS12995 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) H4F70_RS13000 ENOG4105DBV ornithine carbamoyltransferase H4F70_RS13005 ENOG4105C8Y Acetylornithine aminotransferase H4F70_RS13010 ENOG4105CAS nag kinase H4F70_RS13015 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) H4F70_RS13020 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase H4F70_RS13025 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) H4F70_RS13030 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) H4F70_RS13040 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) H4F70_RS13045 ENOG41084BS 50S ribosomal protein L35 H4F70_RS13060 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) H4F70_RS13075 ENOG4107VMB Beta-lactamase domain protein H4F70_RS13115 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) H4F70_RS13125 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) H4F70_RS13135 ENOG4105E5Q amino acid AbC transporter H4F70_RS13140 ENOG4106PMH Extracellular solute-binding protein family 3 H4F70_RS13155 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase H4F70_RS13160 ENOG4105C8J )-transporter H4F70_RS13180 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) H4F70_RS13190 ENOG4108D32 Methyltransferase H4F70_RS13195 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein H4F70_RS13205 ENOG4105C29 acyl-CoA thioesterase H4F70_RS13220 ENOG4107V6M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) H4F70_RS13225 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) H4F70_RS13235 ENOG4105DK0 Indole-3-glycerol phosphate synthase H4F70_RS13245 ENOG4105CRQ synthase (Component I) H4F70_RS13260 ENOG4108KPJ rna polymerase sigma factor H4F70_RS13270 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) H4F70_RS13275 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) H4F70_RS13285 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) H4F70_RS13290 ENOG4108MWI inositol mono-phosphatase H4F70_RS13295 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase H4F70_RS13305 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) H4F70_RS13315 ENOG4105ECC imidazole-glycerol-phosphate dehydratase H4F70_RS13320 ENOG4105CIH Imidazole acetol-phosphate transaminase H4F70_RS13325 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) H4F70_RS13425 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) H4F70_RS13430 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) H4F70_RS13435 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) H4F70_RS13450 ENOG4108BAS reductase H4F70_RS13460 ENOG4105C57 major facilitator superfamily H4F70_RS13525 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) H4F70_RS13530 ENOG4105DFA alanine racemase domain protein H4F70_RS13535 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase H4F70_RS13540 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) H4F70_RS13545 ENOG4105ME9 cell division protein FtsQ H4F70_RS13550 ENOG4105DFU Cell wall formation (By similarity) H4F70_RS13555 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) H4F70_RS13570 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) H4F70_RS13575 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) H4F70_RS13590 ENOG4105CJN penicillin-binding protein H4F70_RS13600 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) H4F70_RS13605 ENOG4108V6E Cell division protein mraZ H4F70_RS13650 ENOG41090CE integral membrane protein H4F70_RS13660 ENOG4105KYH transcriptional regulatory protein H4F70_RS13670 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase H4F70_RS13685 ENOG4105DKQ ROK family H4F70_RS13695 ENOG4105D0U Arsenite-activated ATPase (ArsA) H4F70_RS13715 ENOG4105JNK Glycosyl transferase (Group 1 H4F70_RS13730 ENOG4105K4H Nlp p60 protein H4F70_RS13745 ENOG4108I0Q anthranilate phosphoribosyltransferase H4F70_RS13755 ENOG4105CCU oxidase (Subunit III) H4F70_RS13775 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase H4F70_RS13780 ENOG4108ZRS Part of cytochrome c oxidase, its function is H4F70_RS13785 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) H4F70_RS13795 ENOG4107T4Z adenosine kinase H4F70_RS13815 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) H4F70_RS13820 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) H4F70_RS13825 ENOG4105CM2 brancheD-chain amino acid aminotransferase H4F70_RS13855 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) H4F70_RS13860 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) H4F70_RS13875 ENOG4105C5F glutamine synthetase H4F70_RS13885 ENOG4105VDM plasmid maintenance system antidote protein, xre family H4F70_RS13895 ENOG4105E90 ABC transporter H4F70_RS13900 ENOG4108IJ8 ABC transporter H4F70_RS13905 ENOG4105E90 ABC transporter H4F70_RS13910 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system H4F70_RS13920 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) H4F70_RS13925 ENOG4105C5F glutamine synthetase H4F70_RS13930 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) H4F70_RS14125 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein H4F70_RS14140 ENOG4108UMN azlc family H4F70_RS14145 ENOG4105KMT branched-chain amino acid H4F70_RS14150 ENOG4105WH1 Two component transcriptional regulator luxr family H4F70_RS14155 ENOG4105BZU Histidine kinase H4F70_RS14165 ENOG4108M15 ABC transporter H4F70_RS14190 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) H4F70_RS14210 ENOG4105CSV Glutaminase H4F70_RS14215 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) H4F70_RS14220 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) H4F70_RS14245 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) H4F70_RS14260 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) H4F70_RS14265 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) H4F70_RS14280 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) H4F70_RS14285 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) H4F70_RS14310 ENOG4107QN2 dihydrolipoyl dehydrogenase H4F70_RS14325 ENOG4105BZP glycoside hydrolase 15-related H4F70_RS14330 ENOG4105EA8 2-Nitropropane dioxygenase H4F70_RS14335 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) H4F70_RS14340 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) H4F70_RS14355 ENOG4105KQC Competence protein H4F70_RS14370 ENOG4105CVJ phosphoglycerate mutase H4F70_RS14380 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) H4F70_RS14390 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit H4F70_RS14395 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) H4F70_RS14400 ENOG4105EG6 Saccharopine dehydrogenase H4F70_RS14405 ENOG4105C9U ATP-dependent DNA helicase RecQ H4F70_RS14410 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase H4F70_RS14415 ENOG4108JPW Aminotransferase H4F70_RS14420 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) H4F70_RS14485 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) H4F70_RS14490 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control H4F70_RS14495 ENOG4105K46 50S ribosomal protein l27 H4F70_RS14500 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) H4F70_RS14505 ENOG4105C03 ribonuclease H4F70_RS14505 ENOG4105C03 ribonuclease H4F70_RS14510 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) H4F70_RS14520 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase H4F70_RS14525 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) H4F70_RS14540 ENOG41080AZ Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) H4F70_RS14550 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) H4F70_RS14560 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase H4F70_RS14565 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase H4F70_RS14605 ENOG4107RQ0 Maleylacetate reductase H4F70_RS14610 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) H4F70_RS14615 ENOG4105D7T ABC transporter H4F70_RS14620 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component H4F70_RS14625 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component H4F70_RS14635 ENOG4105CN8 Transcriptional regulator H4F70_RS14670 ENOG4105C85 amino acid H4F70_RS14685 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) H4F70_RS14690 ENOG4107HP6 Transcriptional regulator H4F70_RS14695 ENOG4105CHU acetyl-coa acetyltransferase H4F70_RS14705 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) H4F70_RS14710 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) H4F70_RS14715 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) H4F70_RS14720 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation H4F70_RS14750 ENOG4108IJ7 Glycine betaine H4F70_RS14770 ENOG4105C9Q fumarate hydratase class II H4F70_RS14800 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H4F70_RS14805 ENOG4105MC2 DSBA oxidoreductase H4F70_RS14810 ENOG4108XW1 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) H4F70_RS14850 ENOG4105C7I Dehydrogenase H4F70_RS14895 ENOG4105EV8 ectoine hydroxylase H4F70_RS14905 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H4F70_RS14925 ENOG4105E1F short-chain dehydrogenase reductase H4F70_RS14930 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) H4F70_RS14940 ENOG4105C7B Threonine dehydratase H4F70_RS14950 ENOG4107UBC ErfK ybiS ycfS ynhG family protein H4F70_RS15010 ENOG4105FA0 parb-like partition protein H4F70_RS15075 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) H4F70_RS15285 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H4F70_RS15325 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) H4F70_RS15340 ENOG4105WH1 Two component transcriptional regulator luxr family H4F70_RS15360 ENOG4108F01 MaoC domain protein H4F70_RS15370 ENOG4105C57 major facilitator superfamily H4F70_RS15405 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) H4F70_RS15410 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) H4F70_RS15440 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) H4F70_RS15445 ENOG4107RKP Nicotinate phosphoribosyltransferase H4F70_RS15450 ENOG4108RWI nicotinamidase H4F70_RS15470 ENOG4105BZ9 Cytochrome C oxidase, subunit I H4F70_RS15495 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H4F70_RS15500 ENOG41080E2 ribosomal-protein-alanine acetyltransferase H4F70_RS15510 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) H4F70_RS15520 ENOG4105E5G Alpha beta hydrolase fold H4F70_RS15535 ENOG4107RA1 nh(3)-dependent nad( ) synthetase H4F70_RS15540 ENOG4105CZN Potassium uptake protein H4F70_RS15545 ENOG4107ZYR domain protein H4F70_RS15550 ENOG4108KB2 LysR family Transcriptional regulator H4F70_RS15615 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) H4F70_RS15620 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) H4F70_RS15625 ENOG4105CAK Cell division ATP-binding protein ftsE H4F70_RS15630 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) H4F70_RS15635 ENOG4107TK4 histidinol-phosphate phosphatase H4F70_RS15645 ENOG4105C1G acyl-Coa dehydrogenase H4F70_RS15680 ENOG4105DJZ UPF0182 protein H4F70_RS15690 ENOG41063PX domain protein H4F70_RS15730 ENOG4107SVH Potassium channel protein H4F70_RS15735 ENOG4105C4R Atp-dependent dna helicase H4F70_RS15745 ENOG4108YIQ Alpha beta hydrolase H4F70_RS15760 ENOG4105JXH GntR family transcriptional regulator H4F70_RS15800 ENOG4105C1J atp-dependent rna helicase H4F70_RS15815 ENOG4108ZM9 phosphoglycerate mutase H4F70_RS15835 ENOG4105CBD Diacylglycerol kinase H4F70_RS15860 ENOG4108Z66 YbaK ebsC protein H4F70_RS15865 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase H4F70_RS15870 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) H4F70_RS15875 ENOG4106A3M Cytochrome p-450 H4F70_RS15880 ENOG4105F2C Acetyl-CoA acetyltransferase H4F70_RS15890 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr H4F70_RS15895 ENOG4105E39 Enoyl-CoA hydratase H4F70_RS15910 ENOG4105EA8 2-Nitropropane dioxygenase H4F70_RS15920 ENOG4105F2C Acetyl-CoA acetyltransferase H4F70_RS15925 ENOG4108RZE Tetr family transcriptional regulator H4F70_RS15930 ENOG4105CHR reductase H4F70_RS15935 ENOG4105CC9 acyl-Coa dehydrogenase H4F70_RS15940 ENOG4105CEY Amp-dependent synthetase and ligase H4F70_RS15945 ENOG4105CC9 acyl-Coa dehydrogenase H4F70_RS15950 ENOG4105C1G acyl-Coa dehydrogenase H4F70_RS15955 ENOG4105D2B acyl-CoA dehydrogenase H4F70_RS15980 ENOG4105MXW flavin reductase domain protein, FMN-binding H4F70_RS15990 ENOG4108KC1 acyl-Coa dehydrogenase H4F70_RS16005 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) H4F70_RS16015 ENOG4108M9J MaoC like domain protein H4F70_RS16020 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F H4F70_RS16025 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein H4F70_RS16050 ENOG410635A Membrane H4F70_RS16085 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) H4F70_RS16125 ENOG4105X7H acyl-CoA dehydrogenase H4F70_RS16130 ENOG4108RK3 acyl-Coa dehydrogenase H4F70_RS16135 ENOG4105D2B acyl-CoA dehydrogenase H4F70_RS16140 ENOG4108SGK Tetr family transcriptional regulator H4F70_RS16145 ENOG4105BZP glycoside hydrolase 15-related H4F70_RS16155 ENOG4105E0A ABC, transporter H4F70_RS16160 ENOG4105CC5 ABC transporter H4F70_RS16205 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) H4F70_RS16210 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) H4F70_RS16275 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H4F70_RS16285 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) H4F70_RS16290 ENOG4108YZJ Pfam:DUF2596 H4F70_RS16295 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) H4F70_RS16310 ENOG4107R4N Cell wall formation (By similarity) H4F70_RS16325 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) H4F70_RS16335 ENOG4107S9D Alpha beta hydrolase H4F70_RS16365 ENOG4106BRA Membrane H4F70_RS16390 ENOG4107RPH Isocitrate lyase H4F70_RS16405 ENOG4108R85 Short chain dehydrogenase H4F70_RS16460 ENOG4105EHG Permease protein H4F70_RS16465 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) H4F70_RS16555 ENOG4105DSE periplasmic solute binding protein H4F70_RS16605 ENOG4105H9W Short-chain dehydrogenase reductase Sdr H4F70_RS16625 ENOG4105BZ9 Cytochrome C oxidase, subunit I H4F70_RS16640 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) H4F70_RS16650 ENOG4108K5P (LipO)protein H4F70_RS16680 ENOG4105K6V RNA polymerase H4F70_RS16695 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase H4F70_RS16730 ENOG4105CVP deoxyribo-dipyrimidine photolyase H4F70_RS16740 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) H4F70_RS16760 ENOG4105D4U had-superfamily hydrolase, subfamily iia H4F70_RS16800 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme H4F70_RS16830 ENOG4105CEY Amp-dependent synthetase and ligase H4F70_RS16885 ENOG4105EC2 ftsk spoIIIe H4F70_RS16895 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin H4F70_RS16925 ENOG4105D65 subunit l H4F70_RS16930 ENOG4105MKQ Monovalent cation H antiporter subunit C H4F70_RS16935 ENOG4108JPZ Monovalent cation H antiporter subunit D H4F70_RS17015 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) H4F70_RS17020 ENOG4105DWF phosphomethylpyrimidine kinase H4F70_RS17040 ENOG4105CJ1 ABC, transporter H4F70_RS17045 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) H4F70_RS17055 ENOG4105MWK D-amino acid dehydrogenase, small subunit H4F70_RS17065 ENOG4105D74 hydrolase H4F70_RS17080 ENOG4105CT1 (ABC) transporter H4F70_RS17095 ENOG4105DYW oxidoreductase H4F70_RS17120 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone H4F70_RS17125 ENOG4105CHR reductase H4F70_RS17130 ENOG4108YZT Adenosylcobinamide kinase H4F70_RS17135 ENOG4105E0A ABC, transporter H4F70_RS17140 ENOG4105EHG Permease protein H4F70_RS17145 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) H4F70_RS17170 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F H4F70_RS17190 ENOG4105WQI isochorismatase H4F70_RS17195 ENOG4105E4F Isochorismate synthase H4F70_RS17200 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase H4F70_RS17205 ENOG4105E93 esterase H4F70_RS17210 ENOG4105E0A ABC, transporter H4F70_RS17215 ENOG4108IHU transport system permease protein H4F70_RS17220 ENOG4105DQ5 transport system permease protein H4F70_RS17230 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase H4F70_RS17235 ENOG4105WQI isochorismatase H4F70_RS17240 ENOG4105CEY Amp-dependent synthetase and ligase H4F70_RS17245 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis H4F70_RS17255 ENOG4107XZ0 Peptidase M50 H4F70_RS17265 ENOG4105PGM cation diffusion facilitator family transporter H4F70_RS17270 ENOG4105K4H Nlp p60 protein H4F70_RS17280 ENOG4105C0R drug resistance transporter emrb qaca subfamily H4F70_RS17300 ENOG4105CTK cobaltochelatase, cobn subunit H4F70_RS17335 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase H4F70_RS17345 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase H4F70_RS17350 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) H4F70_RS17355 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) H4F70_RS17365 ENOG4106A3M Cytochrome p-450 H4F70_RS17370 ENOG4105CHR reductase H4F70_RS17375 ENOG4105C26 Dehydrogenase H4F70_RS17410 ENOG4105CEY Amp-dependent synthetase and ligase H4F70_RS17425 ENOG4108SGK Tetr family transcriptional regulator H4F70_RS17430 ENOG4107S2E monooxygenase H4F70_RS17450 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) H4F70_RS17460 ENOG4105J76 Periplasmic binding protein H4F70_RS17465 ENOG4105DQ5 transport system permease protein H4F70_RS17470 ENOG4105DQ5 transport system permease protein H4F70_RS17475 ENOG4105E0A ABC, transporter H4F70_RS17495 ENOG4105DQR SNARE associated Golgi H4F70_RS17500 ENOG4105DQR SNARE associated Golgi H4F70_RS17550 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit H4F70_RS17570 ENOG4105HDK L-asparaginase H4F70_RS17575 ENOG4105CHR reductase H4F70_RS17580 ENOG4105H9W Short-chain dehydrogenase reductase Sdr H4F70_RS17590 ENOG4105ETE Transcriptional regulator (LacI family H4F70_RS17595 ENOG4105CEY Amp-dependent synthetase and ligase H4F70_RS17605 ENOG4105C26 Dehydrogenase H4F70_RS17615 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase H4F70_RS17640 ENOG41082YX Transcriptional regulator, arsr family H4F70_RS17665 ENOG4105KNI merR family transcriptional Regulator H4F70_RS17670 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) H4F70_RS17675 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ H4F70_RS17680 ENOG4105CFG Acts as a chaperone (By similarity) H4F70_RS17700 ENOG4105DF6 Fe-S oxidoreductase H4F70_RS17705 ENOG4105WH1 Two component transcriptional regulator luxr family H4F70_RS17735 ENOG4108K81 inner membrane protein YghB H4F70_RS17785 ENOG4105CV8 reductase H4F70_RS17805 ENOG4105KRQ Addiction module toxin, Txe YoeB family H4F70_RS17810 ENOG4105VTW prevent-host-death family H4F70_RS17820 ENOG4105CHF Glutathione S-transferase H4F70_RS17825 ENOG41088CC tellurite resistance protein tehB H4F70_RS17830 ENOG4105EEF Alkane 1-monooxygenase H4F70_RS17835 ENOG41084UD rubredoxin H4F70_RS17840 ENOG4105VCQ rubredoxin H4F70_RS17850 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) H4F70_RS17860 ENOG4105CSU acyl-Coa dehydrogenase H4F70_RS17865 ENOG4108UCS ABC, transporter H4F70_RS17885 ENOG4108IG5 Transcriptional regulator H4F70_RS17910 ENOG4105CHU acetyl-coa acetyltransferase H4F70_RS17915 ENOG4105CHR reductase H4F70_RS17950 ENOG41073B4 coagulation factor 5 8 type domain-containing protein H4F70_RS17985 ENOG4108M6P methyltransferase H4F70_RS17995 ENOG4108M6P methyltransferase H4F70_RS18020 ENOG4108UKI Enoyl-CoA hydratase H4F70_RS18025 ENOG4105EUB pirin domain protein H4F70_RS18030 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) H4F70_RS18035 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) H4F70_RS18055 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) H4F70_RS18065 ENOG4107R13 MMPL domain protein H4F70_RS18080 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) H4F70_RS18085 ENOG4105DMF Dehydrogenase H4F70_RS18090 ENOG4105K5B UPF0225 protein H4F70_RS18095 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase H4F70_RS18150 ENOG4108YYC ycei family H4F70_RS18160 ENOG4105DUX Transporter H4F70_RS18165 ENOG4107ZR7 Membrane H4F70_RS18170 ENOG4105DUM transcriptional regulator, lysR family H4F70_RS18180 ENOG4105C28 cystathionine H4F70_RS18205 ENOG4105C9K Endothelin-converting enzyme 1 H4F70_RS18210 ENOG4105F9E Shikimate 5-dehydrogenase H4F70_RS18240 ENOG4107UBC ErfK ybiS ycfS ynhG family protein H4F70_RS18250 ENOG4105CQB FAD linked oxidase domain protein H4F70_RS18255 ENOG41080RH Thioredoxin H4F70_RS18260 ENOG4105C01 Dihydroxy-acid dehydratase H4F70_RS18270 ENOG4108QER Adenylate cyclase H4F70_RS18295 ENOG41080V3 Major Facilitator superfamily H4F70_RS18300 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family H4F70_RS18310 ENOG4108IRC dna polymerase iii H4F70_RS18320 ENOG4105C1G acyl-Coa dehydrogenase H4F70_RS18325 ENOG4105CEY Amp-dependent synthetase and ligase H4F70_RS18330 ENOG4105CHR reductase H4F70_RS18335 ENOG4108UKI Enoyl-CoA hydratase H4F70_RS18350 ENOG4105C1G acyl-Coa dehydrogenase H4F70_RS18360 ENOG4107RM1 amidohydrolase H4F70_RS18395 ENOG4108RPX mosc domain containing protein H4F70_RS18405 ENOG4105EUZ Beta-lactamase domain protein H4F70_RS18410 ENOG4105WH1 Two component transcriptional regulator luxr family H4F70_RS18440 ENOG4105C1G acyl-Coa dehydrogenase H4F70_RS18445 ENOG4108Z4U Ferredoxin H4F70_RS18460 ENOG4105CPC Aldo Keto reductase H4F70_RS18475 ENOG4105C57 major facilitator superfamily H4F70_RS18520 ENOG4105C1B dTDP-glucose 4-6-dehydratase H4F70_RS18530 ENOG4105CSU acyl-Coa dehydrogenase H4F70_RS18535 ENOG4105MXW flavin reductase domain protein, FMN-binding H4F70_RS18560 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr H4F70_RS18565 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H4F70_RS18575 ENOG4108UU4 oxidoreductase (Short chain dehydrogenase reductase family) H4F70_RS18580 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase H4F70_RS18590 ENOG4107FW0 short-chain dehydrogenase reductase H4F70_RS18605 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) H4F70_RS18610 ENOG4106HK8 GPR1 FUN34 yaaH family protein H4F70_RS18620 ENOG4105C5Q Transcriptional regulator H4F70_RS18635 ENOG4105CEY Amp-dependent synthetase and ligase H4F70_RS18655 ENOG4108JQ7 (ABC) transporter H4F70_RS18680 ENOG4105C1G acyl-Coa dehydrogenase H4F70_RS18690 ENOG4105EUZ Beta-lactamase domain protein H4F70_RS18715 ENOG4105CEY Amp-dependent synthetase and ligase H4F70_RS18730 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) H4F70_RS18745 ENOG4108UVJ appr-1-p processing domain protein H4F70_RS18835 ENOG4107EFR Flavocytochrome c H4F70_RS18870 ENOG4105CK7 Sodium proline symporter H4F70_RS18875 ENOG4105CEY Amp-dependent synthetase and ligase H4F70_RS18880 ENOG4108JIK carboxylase H4F70_RS18890 ENOG4105CJ1 ABC, transporter H4F70_RS18930 ENOG4105C57 major facilitator superfamily H4F70_RS18940 ENOG4108ZGX Histidine kinase H4F70_RS18945 ENOG4105WH1 Two component transcriptional regulator luxr family H4F70_RS18970 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) H4F70_RS18975 ENOG4107QR9 Iron-sulfur cluster binding protein H4F70_RS18980 ENOG41080R8 Conserved Protein H4F70_RS19035 ENOG4105E39 Enoyl-CoA hydratase H4F70_RS19040 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) H4F70_RS19050 ENOG410901E Membrane H4F70_RS19055 ENOG4105MWK D-amino acid dehydrogenase, small subunit H4F70_RS19065 ENOG4105CEP NADH dehydrogenase H4F70_RS19070 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes H4F70_RS19080 ENOG4105CSH Transporter H4F70_RS19085 ENOG4105C0R drug resistance transporter emrb qaca subfamily H4F70_RS19095 ENOG4105KHC sulfurtransferase H4F70_RS19120 ENOG4107QWP ABC-2 type transporter H4F70_RS19185 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) H4F70_RS19220 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H4F70_RS19235 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein H4F70_RS19250 ENOG4105EBR Carboxylesterase H4F70_RS19265 ENOG41090G8 Toxic component of a toxin-antitoxin (TA) module. A H4F70_RS19275 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase H4F70_RS19295 ENOG4105C1G acyl-Coa dehydrogenase H4F70_RS19300 ENOG4108UKI Enoyl-CoA hydratase H4F70_RS19305 ENOG4108BAS reductase H4F70_RS19315 ENOG4108R85 Short chain dehydrogenase H4F70_RS19325 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) H4F70_RS19330 ENOG4105EHG Permease protein H4F70_RS19340 ENOG4105CSU acyl-Coa dehydrogenase H4F70_RS19365 ENOG4105CEY Amp-dependent synthetase and ligase H4F70_RS19370 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein H4F70_RS19395 ENOG4105CEY Amp-dependent synthetase and ligase H4F70_RS19410 ENOG41082VC UPF0145 protein H4F70_RS19420 ENOG4108UZX fmn reductase H4F70_RS19435 ENOG4105VEQ Cold shock protein H4F70_RS19440 ENOG4105XYF acetyltransferase H4F70_RS19455 ENOG4105BZN citrate synthase H4F70_RS19460 ENOG4105CR4 methylisocitrate lyase H4F70_RS19495 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) H4F70_RS19505 ENOG4107R37 Glutamate dehydrogenase H4F70_RS19510 ENOG4108JPW Aminotransferase H4F70_RS19520 ENOG4105DV0 amidase (EC 3.5.1.4 H4F70_RS19530 ENOG4105DBE peroxidase H4F70_RS19535 ENOG410650H (LipO)protein H4F70_RS19545 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase H4F70_RS19565 ENOG4105CHR reductase H4F70_RS19575 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold H4F70_RS19580 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase H4F70_RS19605 ENOG4107EFR Flavocytochrome c H4F70_RS19660 ENOG4105E2B Taurine dioxygenase H4F70_RS19685 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr H4F70_RS19690 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H4F70_RS19695 ENOG4105C26 Dehydrogenase H4F70_RS19700 ENOG4105E3J oxidoreductase H4F70_RS19705 ENOG4105C26 Dehydrogenase H4F70_RS19710 ENOG41061TZ Short-chain dehydrogenase reductase Sdr H4F70_RS19720 ENOG4105DVW rieske (2Fe-2S) H4F70_RS19725 ENOG4105C94 Transporter H4F70_RS19745 ENOG4105EMY transcriptional regulator H4F70_RS19755 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component H4F70_RS19775 ENOG4105CPC Aldo Keto reductase H4F70_RS19800 ENOG4105K9Q Binds to the 23S rRNA (By similarity) H4F70_RS19805 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) H4F70_RS19815 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) H4F70_RS19850 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) H4F70_RS19860 ENOG4105BZ4 penicillin-binding protein H4F70_RS19870 ENOG4105VUN Transcriptional regulator H4F70_RS19875 ENOG4105CZA synthase H4F70_RS19945 ENOG4108K7T Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases H4F70_RS19955 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 H4F70_RS19965 ENOG4105DXB Major Facilitator superfamily H4F70_RS19970 ENOG4105MXW flavin reductase domain protein, FMN-binding H4F70_RS19975 ENOG4105EMU Dehydrogenase H4F70_RS20005 ENOG4105C8T Leucyl-tRNA synthetase H4F70_RS20015 ENOG4105DHU Bile acid H4F70_RS20030 ENOG41081DT UPF0301 protein H4F70_RS20045 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate H4F70_RS20075 ENOG4105C3M thioredoxin reductase H4F70_RS20080 ENOG4105C3M thioredoxin reductase H4F70_RS20085 ENOG4108E1C hydrolase H4F70_RS20105 ENOG4107QJE Chromosome Partitioning Protein H4F70_RS20110 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) H4F70_RS20120 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins H4F70_RS20125 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) H4F70_RS20130 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)