locus-tag	class	description
H4F70_RS00010	COG0592	DNA-directed DNA polymerase activity
H4F70_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H4F70_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
H4F70_RS00025	COG0187	DNA topoisomerase II activity
H4F70_RS00040	COG2267	carboxylic ester hydrolase activity
H4F70_RS00050	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H4F70_RS00050	COG2146	nitrite reductase [NAD(P)H] activity
H4F70_RS00055	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H4F70_RS00055	COG2146	nitrite reductase [NAD(P)H] activity
H4F70_RS00060	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H4F70_RS00065	COG0243	molybdopterin cofactor binding
H4F70_RS00070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H4F70_RS00070	COG1372	Participates in initiation and elongation during chromosome replication
H4F70_RS00110	COG0302	gtp cyclohydrolase
H4F70_RS00180	COG0747	negative chemotaxis
H4F70_RS00195	COG2267	carboxylic ester hydrolase activity
H4F70_RS00205	COG4974	Belongs to the 'phage' integrase family
H4F70_RS00260	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H4F70_RS00300	COG2807	transmembrane transport
H4F70_RS00305	COG2855	membrane
H4F70_RS00370	COG1302	Protein conserved in bacteria
H4F70_RS00455	COG2801	Transposase and inactivated derivatives
H4F70_RS00460	COG4974	Belongs to the 'phage' integrase family
H4F70_RS00465	COG0582	viral genome integration into host DNA
H4F70_RS00470	COG4974	Belongs to the 'phage' integrase family
H4F70_RS00500	COG0477	Major facilitator Superfamily
H4F70_RS00520	COG1473	amidohydrolase
H4F70_RS00530	COG2132	Multicopper oxidase
H4F70_RS00540	COG0318	PFAM AMP-dependent synthetase and ligase
H4F70_RS00545	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H4F70_RS00555	COG0318	PFAM AMP-dependent synthetase and ligase
H4F70_RS00560	COG4608	Belongs to the ABC transporter superfamily
H4F70_RS00580	COG0346	lactoylglutathione lyase activity
H4F70_RS00585	COG1309	transcriptional regulator
H4F70_RS00595	COG0183	Belongs to the thiolase family
H4F70_RS00600	COG4948	Mandelate Racemase Muconate Lactonizing
H4F70_RS00660	COG1309	transcriptional regulator
H4F70_RS00670	COG1131	(ABC) transporter
H4F70_RS00705	COG0477	Major facilitator Superfamily
H4F70_RS00730	COG2826	transposase and inactivated derivatives, IS30 family
H4F70_RS00735	COG2826	transposase and inactivated derivatives, IS30 family
H4F70_RS00775	COG2072	flavoprotein involved in K transport
H4F70_RS00780	COG0583	DNA-binding transcription factor activity
H4F70_RS00785	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H4F70_RS00810	COG4101	3-hydroxyanthranilate 3,4-dioxygenase activity
H4F70_RS00820	COG0477	Major facilitator Superfamily
H4F70_RS00825	COG1234	tRNA 3'-trailer cleavage
H4F70_RS00835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4F70_RS00840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4F70_RS00845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H4F70_RS00845	COG1116	anion transmembrane transporter activity
H4F70_RS00850	COG3609	addiction module antidote protein, CC2985 family
H4F70_RS00855	COG2337	Toxic component of a toxin-antitoxin (TA) module
H4F70_RS00865	COG1063	alcohol dehydrogenase
H4F70_RS00880	COG1414	Transcriptional regulator
H4F70_RS00885	COG3971	2-oxopent-4-enoate hydratase activity
H4F70_RS00890	COG4569	acetaldehyde dehydrogenase (acetylating) activity
H4F70_RS00895	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H4F70_RS00905	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H4F70_RS00905	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H4F70_RS00915	COG2818	Glycosylase
H4F70_RS00920	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H4F70_RS00930	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H4F70_RS00955	COG2801	Transposase and inactivated derivatives
H4F70_RS00960	COG1970	mechanosensitive ion channel activity
H4F70_RS01005	COG2815	serine threonine protein kinase
H4F70_RS01005	COG0515	serine threonine protein kinase
H4F70_RS01010	COG0515	serine threonine protein kinase
H4F70_RS01015	COG0768	penicillin binding
H4F70_RS01030	COG1716	ATPase activity
H4F70_RS01035	COG1716	ATPase activity
H4F70_RS01055	COG0277	FAD linked oxidase domain protein
H4F70_RS01075	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H4F70_RS01125	COG2272	Belongs to the type-B carboxylesterase lipase family
H4F70_RS01150	COG1024	Enoyl-CoA hydratase
H4F70_RS01160	COG0477	Major facilitator Superfamily
H4F70_RS01170	COG1218	3'(2'),5'-bisphosphate nucleotidase
H4F70_RS01175	COG0175	sulfate reduction
H4F70_RS01200	COG2026	Addiction module toxin, RelE StbE family
H4F70_RS01210	COG0747	negative chemotaxis
H4F70_RS01230	COG1414	Transcriptional regulator
H4F70_RS01240	COG1012	belongs to the aldehyde dehydrogenase family
H4F70_RS01285	COG0477	Major facilitator Superfamily
H4F70_RS01300	COG0492	ferredoxin-NADP+ reductase activity
H4F70_RS01320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4F70_RS01335	COG2030	dehydratase
H4F70_RS01335	COG1012	belongs to the aldehyde dehydrogenase family
H4F70_RS01340	COG1024	Enoyl-CoA hydratase
H4F70_RS01360	COG0318	PFAM AMP-dependent synthetase and ligase
H4F70_RS01370	COG0583	DNA-binding transcription factor activity
H4F70_RS01375	COG0583	DNA-binding transcription factor activity
H4F70_RS01385	COG1960	acyl-CoA dehydrogenase activity
H4F70_RS01425	COG1960	acyl-CoA dehydrogenase activity
H4F70_RS01435	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS01450	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H4F70_RS01455	COG1309	transcriptional regulator
H4F70_RS01460	COG0833	amino acid
H4F70_RS01470	COG3842	ATPase activity
H4F70_RS01475	COG1177	transmembrane transport
H4F70_RS01480	COG1176	ABC-type spermidine putrescine transport system, permease component I
H4F70_RS01500	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H4F70_RS01540	COG0709	Synthesizes selenophosphate from selenide and ATP
H4F70_RS01550	COG1921	L-seryl-tRNASec selenium transferase activity
H4F70_RS01575	COG0437	4 iron, 4 sulfur cluster binding
H4F70_RS01605	COG2409	Drug exporters of the RND superfamily
H4F70_RS01625	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H4F70_RS01640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H4F70_RS01645	COG0596	Alpha beta hydrolase
H4F70_RS01675	COG1233	COG1233 Phytoene dehydrogenase and related
H4F70_RS01680	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS01695	COG1960	acyl-CoA dehydrogenase activity
H4F70_RS01705	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS01735	COG1960	acyl-CoA dehydrogenase activity
H4F70_RS01740	COG1609	Transcriptional regulator
H4F70_RS01745	COG0477	Major facilitator Superfamily
H4F70_RS01750	COG1937	Protein conserved in bacteria
H4F70_RS01800	COG0745	RESPONSE REGULATOR receiver
H4F70_RS01805	COG5000	phosphorelay sensor kinase activity
H4F70_RS01805	COG5002	protein histidine kinase activity
H4F70_RS01815	COG2814	Major facilitator Superfamily
H4F70_RS01825	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H4F70_RS01835	COG0531	amino acid
H4F70_RS01860	COG2197	response regulator
H4F70_RS01865	COG1126	abc transporter atp-binding protein
H4F70_RS01870	COG0765	amino acid transport
H4F70_RS01875	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
H4F70_RS01880	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
H4F70_RS01885	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H4F70_RS01890	COG3639	organic phosphonate transmembrane transporter activity
H4F70_RS01900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H4F70_RS01905	COG1063	alcohol dehydrogenase
H4F70_RS01925	COG0346	lactoylglutathione lyase activity
H4F70_RS01945	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4F70_RS02010	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS02030	COG1960	acyl-CoA dehydrogenase activity
H4F70_RS02035	COG1902	pentaerythritol trinitrate reductase activity
H4F70_RS02035	COG0446	pyridine nucleotide-disulphide oxidoreductase
H4F70_RS02040	COG3959	Transketolase, thiamine diphosphate binding domain
H4F70_RS02045	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H4F70_RS02055	COG0318	PFAM AMP-dependent synthetase and ligase
H4F70_RS02055	COG0204	Acyl-transferase
H4F70_RS02070	COG1414	Transcriptional regulator
H4F70_RS02075	COG1309	transcriptional regulator
H4F70_RS02080	COG1304	FMN binding
H4F70_RS02085	COG0747	negative chemotaxis
H4F70_RS02090	COG0251	oxidation-reduction process
H4F70_RS02095	COG0667	Aldo Keto reductase
H4F70_RS02100	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS02105	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS02110	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS02145	COG2267	carboxylic ester hydrolase activity
H4F70_RS02155	COG1053	succinate dehydrogenase
H4F70_RS02180	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS02185	COG1053	succinate dehydrogenase
H4F70_RS02205	COG1228	amidohydrolase
H4F70_RS02215	COG2072	flavoprotein involved in K transport
H4F70_RS02225	COG2814	Major facilitator Superfamily
H4F70_RS02240	COG4552	Acetyltransferase involved in intracellular survival and related
H4F70_RS02270	COG1285	pathogenesis
H4F70_RS02305	COG0668	transmembrane transport
H4F70_RS02330	COG1511	domain protein
H4F70_RS02340	COG0076	glutamate decarboxylase activity
H4F70_RS02360	COG1045	serine acetyltransferase
H4F70_RS02365	COG2072	flavoprotein involved in K transport
H4F70_RS02370	COG0069	glutamate synthase activity
H4F70_RS02370	COG0070	glutamate synthase
H4F70_RS02370	COG0067	glutamate synthase
H4F70_RS02385	COG2501	S4 domain
H4F70_RS02390	COG1309	transcriptional regulator
H4F70_RS02395	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS02400	COG1902	pentaerythritol trinitrate reductase activity
H4F70_RS02400	COG0446	pyridine nucleotide-disulphide oxidoreductase
H4F70_RS02415	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H4F70_RS02445	COG0789	Transcriptional regulator
H4F70_RS02450	COG1012	belongs to the aldehyde dehydrogenase family
H4F70_RS02535	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H4F70_RS02540	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H4F70_RS02550	COG1472	Belongs to the glycosyl hydrolase 3 family
H4F70_RS02555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4F70_RS02560	COG2329	Antibiotic biosynthesis monooxygenase
H4F70_RS02565	COG0425	Belongs to the sulfur carrier protein TusA family
H4F70_RS02565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H4F70_RS02585	COG1316	TRANSCRIPTIONal
H4F70_RS02650	COG0747	negative chemotaxis
H4F70_RS02660	COG0444	Belongs to the ABC transporter superfamily
H4F70_RS02675	COG1609	Transcriptional regulator
H4F70_RS02680	COG1904	glucuronate isomerase
H4F70_RS02685	COG0246	Mannitol dehydrogenase
H4F70_RS02690	COG3250	beta-galactosidase activity
H4F70_RS02695	COG4948	Mandelate Racemase Muconate Lactonizing
H4F70_RS02700	COG3265	gluconokinase activity
H4F70_RS02770	COG2146	nitrite reductase [NAD(P)H] activity
H4F70_RS02770	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H4F70_RS02780	COG0561	phosphatase activity
H4F70_RS02785	COG2385	sporulation resulting in formation of a cellular spore
H4F70_RS02795	COG1216	Glycosyl transferase, family 2
H4F70_RS02805	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H4F70_RS02810	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H4F70_RS02820	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H4F70_RS02820	COG5479	isomerase activity
H4F70_RS02840	COG0318	PFAM AMP-dependent synthetase and ligase
H4F70_RS02850	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H4F70_RS02875	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS02880	COG0277	FAD linked oxidase domain protein
H4F70_RS02890	COG1216	Glycosyl transferase, family 2
H4F70_RS02900	COG1012	belongs to the aldehyde dehydrogenase family
H4F70_RS02910	COG0432	Pfam Uncharacterised protein family UPF0047
H4F70_RS02915	COG1216	Glycosyl transferase, family 2
H4F70_RS02960	COG0737	Belongs to the 5'-nucleotidase family
H4F70_RS02965	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H4F70_RS02995	COG0154	amidase activity
H4F70_RS03000	COG0287	Prephenate dehydrogenase
H4F70_RS03010	COG0590	tRNA wobble adenosine to inosine editing
H4F70_RS03025	COG4249	Peptidase C14 caspase catalytic subunit p20
H4F70_RS03025	COG2319	Wd-40 repeat
H4F70_RS03035	COG1937	Protein conserved in bacteria
H4F70_RS03040	COG0343	queuine tRNA-ribosyltransferase activity
H4F70_RS03050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H4F70_RS03055	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H4F70_RS03075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4F70_RS03085	COG1376	ErfK ybiS ycfS ynhG family protein
H4F70_RS03090	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H4F70_RS03145	COG1403	HNH endonuclease
H4F70_RS03155	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H4F70_RS03165	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H4F70_RS03170	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H4F70_RS03180	COG1492	cobalamin metabolic process
H4F70_RS03185	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H4F70_RS03190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H4F70_RS03195	COG0753	catalase activity
H4F70_RS03200	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H4F70_RS03220	COG1752	Esterase of the alpha-beta hydrolase superfamily
H4F70_RS03225	COG0252	asparaginase activity
H4F70_RS03240	COG3360	Dodecin
H4F70_RS03245	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H4F70_RS03250	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H4F70_RS03265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H4F70_RS03275	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4F70_RS03280	COG3246	L-lysine catabolic process to acetate
H4F70_RS03290	COG4533	DNA binding
H4F70_RS03330	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H4F70_RS03360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4F70_RS03380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4F70_RS03395	COG0596	Alpha beta hydrolase
H4F70_RS03405	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H4F70_RS03460	COG1111	helicase
H4F70_RS03460	COG1205	dead DEAH box helicase
H4F70_RS03475	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H4F70_RS03475	COG1754	DNA topoisomerase type I activity
H4F70_RS03520	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
H4F70_RS03525	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H4F70_RS03530	COG3842	ATPase activity
H4F70_RS03555	COG1131	(ABC) transporter
H4F70_RS03565	COG0183	Belongs to the thiolase family
H4F70_RS03605	COG1024	Enoyl-CoA hydratase
H4F70_RS03615	COG0477	Major facilitator Superfamily
H4F70_RS03625	COG2027	D-alanyl-D-alanine carboxypeptidase
H4F70_RS03635	COG0037	tRNA processing
H4F70_RS03650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H4F70_RS03655	COG0302	gtp cyclohydrolase
H4F70_RS03690	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H4F70_RS03695	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H4F70_RS03700	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H4F70_RS03710	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H4F70_RS03735	COG1764	response to oxidative stress
H4F70_RS03755	COG0288	reversible hydration of carbon dioxide
H4F70_RS03765	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
H4F70_RS03775	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H4F70_RS03780	COG2847	Copper chaperone PCu(A)C
H4F70_RS03785	COG1329	Transcriptional regulator
H4F70_RS03790	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H4F70_RS03790	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H4F70_RS03800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H4F70_RS03805	COG1960	acyl-CoA dehydrogenase activity
H4F70_RS03820	COG0406	alpha-ribazole phosphatase activity
H4F70_RS03830	COG0785	Cytochrome C biogenesis protein
H4F70_RS03840	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H4F70_RS03855	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H4F70_RS03875	COG0542	response to heat
H4F70_RS03945	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H4F70_RS03955	COG4948	Mandelate Racemase Muconate Lactonizing
H4F70_RS03970	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H4F70_RS03980	COG2226	methyltransferase
H4F70_RS03985	COG0644	oxidoreductase
H4F70_RS04005	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H4F70_RS04010	COG1666	GTP binding
H4F70_RS04040	COG2030	dehydratase
H4F70_RS04060	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H4F70_RS04065	COG0081	regulation of translation
H4F70_RS04085	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H4F70_RS04090	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H4F70_RS04120	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H4F70_RS04145	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H4F70_RS04160	COG0477	Major facilitator Superfamily
H4F70_RS04190	COG1309	transcriptional regulator
H4F70_RS04195	COG0183	Belongs to the thiolase family
H4F70_RS04205	COG2030	dehydratase
H4F70_RS04210	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS04215	COG1960	acyl-CoA dehydrogenase activity
H4F70_RS04220	COG2226	methyltransferase
H4F70_RS04235	COG0604	alcohol dehydrogenase
H4F70_RS04260	COG1960	acyl-CoA dehydrogenase activity
H4F70_RS04265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H4F70_RS04285	COG1309	transcriptional regulator
H4F70_RS04290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H4F70_RS04290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H4F70_RS04310	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H4F70_RS04315	COG0049	tRNA binding
H4F70_RS04320	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H4F70_RS04325	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H4F70_RS04340	COG0367	asparagine synthase
H4F70_RS04345	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H4F70_RS04350	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H4F70_RS04355	COG3239	Fatty acid desaturase
H4F70_RS04435	COG1302	Protein conserved in bacteria
H4F70_RS04440	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4F70_RS04455	COG1140	nitrate reductase beta subunit
H4F70_RS04475	COG1309	transcriptional regulator
H4F70_RS04480	COG1802	Transcriptional regulator
H4F70_RS04485	COG1960	acyl-CoA dehydrogenase activity
H4F70_RS04500	COG4044	May play a role in the intracellular transport of hydrophobic ligands
H4F70_RS04505	COG1309	transcriptional regulator
H4F70_RS04515	COG0318	PFAM AMP-dependent synthetase and ligase
H4F70_RS04575	COG0051	transcription antitermination factor activity, RNA binding
H4F70_RS04585	COG0088	Forms part of the polypeptide exit tunnel
H4F70_RS04590	COG0089	rRNA binding
H4F70_RS04595	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H4F70_RS04600	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H4F70_RS04605	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H4F70_RS04610	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H4F70_RS04635	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H4F70_RS04640	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H4F70_RS04655	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H4F70_RS04660	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H4F70_RS04675	COG0200	Binds to the 23S rRNA
H4F70_RS04685	COG0563	adenylate kinase activity
H4F70_RS04695	COG0789	Transcriptional regulator
H4F70_RS04700	COG0667	Aldo Keto reductase
H4F70_RS04705	COG1490	D-aminoacyl-tRNA deacylase activity
H4F70_RS04715	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H4F70_RS04720	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H4F70_RS04725	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H4F70_RS04730	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H4F70_RS04740	COG0202	RNA polymerase activity
H4F70_RS04745	COG0203	ribosomal protein L17
H4F70_RS04750	COG0101	tRNA pseudouridine synthase activity
H4F70_RS04760	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H4F70_RS04770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H4F70_RS04795	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H4F70_RS04810	COG0463	Glycosyl transferase, family 2
H4F70_RS04825	COG0726	polysaccharide deacetylase
H4F70_RS04855	COG1309	transcriptional regulator
H4F70_RS04875	COG0456	acetyltransferase
H4F70_RS04880	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H4F70_RS04890	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H4F70_RS04930	COG0516	GMP reductase activity
H4F70_RS04965	COG2197	response regulator
H4F70_RS04970	COG3507	Belongs to the glycosyl hydrolase 43 family
H4F70_RS04975	COG2815	serine threonine protein kinase
H4F70_RS04975	COG0515	serine threonine protein kinase
H4F70_RS05070	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H4F70_RS05095	COG0657	acetylesterase activity
H4F70_RS05110	COG0587	DNA-directed DNA polymerase activity
H4F70_RS05130	COG1668	transmembrane transport
H4F70_RS05135	COG4152	abc transporter atp-binding protein
H4F70_RS05150	COG0488	(ABC) transporter
H4F70_RS05155	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H4F70_RS05165	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H4F70_RS05180	COG2873	o-acetylhomoserine
H4F70_RS05190	COG2814	Major facilitator Superfamily
H4F70_RS05195	COG0708	Exodeoxyribonuclease III
H4F70_RS05210	COG0517	IMP dehydrogenase activity
H4F70_RS05215	COG0180	Tryptophanyl-tRNA synthetase
H4F70_RS05220	COG1295	ribonuclease BN
H4F70_RS05225	COG0277	FAD linked oxidase domain protein
H4F70_RS05225	COG0247	lactate metabolic process
H4F70_RS05270	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H4F70_RS05275	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H4F70_RS05290	COG2009	succinate dehydrogenase
H4F70_RS05305	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H4F70_RS05325	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H4F70_RS05345	COG1473	amidohydrolase
H4F70_RS05345	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H4F70_RS05360	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H4F70_RS05385	COG4770	biotin carboxylase activity
H4F70_RS05410	COG0424	maF-like protein
H4F70_RS05420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H4F70_RS05445	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H4F70_RS05450	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H4F70_RS05470	COG0277	FAD linked oxidase domain protein
H4F70_RS05490	COG1316	TRANSCRIPTIONal
H4F70_RS05505	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H4F70_RS05520	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
H4F70_RS05520	COG0778	Nitroreductase
H4F70_RS05540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H4F70_RS05545	COG2835	tetraacyldisaccharide 4'-kinase activity
H4F70_RS05555	COG1482	cell wall glycoprotein biosynthetic process
H4F70_RS05595	COG0745	RESPONSE REGULATOR receiver
H4F70_RS05600	COG5002	protein histidine kinase activity
H4F70_RS05615	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H4F70_RS05620	COG0653	protein targeting
H4F70_RS05680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4F70_RS05715	COG1024	Enoyl-CoA hydratase
H4F70_RS05725	COG2070	2-Nitropropane dioxygenase
H4F70_RS05755	COG1960	acyl-CoA dehydrogenase activity
H4F70_RS05760	COG1960	acyl-CoA dehydrogenase activity
H4F70_RS05770	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H4F70_RS05775	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H4F70_RS05800	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H4F70_RS05820	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H4F70_RS05845	COG2193	ferroxidase activity
H4F70_RS05860	COG0537	adenosine 5'-monophosphoramidase activity
H4F70_RS05865	COG0151	Belongs to the GarS family
H4F70_RS05870	COG0436	Aminotransferase
H4F70_RS05880	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H4F70_RS05885	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H4F70_RS05905	COG0386	Belongs to the glutathione peroxidase family
H4F70_RS05915	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H4F70_RS05920	COG0047	phosphoribosylformylglycinamidine synthase activity
H4F70_RS05935	COG1362	aminopeptidase activity
H4F70_RS05965	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H4F70_RS05975	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H4F70_RS05990	COG4044	May play a role in the intracellular transport of hydrophobic ligands
H4F70_RS06000	COG2897	thiosulfate sulfurtransferase activity
H4F70_RS06020	COG0745	RESPONSE REGULATOR receiver
H4F70_RS06025	COG0456	acetyltransferase
H4F70_RS06025	COG0454	-acetyltransferase
H4F70_RS06045	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H4F70_RS06065	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H4F70_RS06080	COG0318	PFAM AMP-dependent synthetase and ligase
H4F70_RS06085	COG0542	response to heat
H4F70_RS06425	COG1475	DNA binding
H4F70_RS06495	COG2176	DNA-directed DNA polymerase activity
H4F70_RS06510	COG1660	Displays ATPase and GTPase activities
H4F70_RS06530	COG0740	serine-type endopeptidase activity
H4F70_RS06605	COG3179	chitinase
H4F70_RS06685	COG4974	Belongs to the 'phage' integrase family
H4F70_RS06715	COG1126	abc transporter atp-binding protein
H4F70_RS06720	COG0765	amino acid transport
H4F70_RS06725	COG0765	amino acid transport
H4F70_RS06735	COG2814	Major facilitator Superfamily
H4F70_RS06750	COG0318	PFAM AMP-dependent synthetase and ligase
H4F70_RS06755	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H4F70_RS06765	COG1960	acyl-CoA dehydrogenase activity
H4F70_RS06770	COG2030	dehydratase
H4F70_RS06790	COG1473	amidohydrolase
H4F70_RS06795	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS06800	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS06810	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H4F70_RS06850	COG1309	transcriptional regulator
H4F70_RS06870	COG0318	PFAM AMP-dependent synthetase and ligase
H4F70_RS06875	COG0318	PFAM AMP-dependent synthetase and ligase
H4F70_RS06885	COG0318	PFAM AMP-dependent synthetase and ligase
H4F70_RS06895	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS06910	COG1960	acyl-CoA dehydrogenase activity
H4F70_RS06925	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H4F70_RS06945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4F70_RS06965	COG1846	Transcriptional regulator
H4F70_RS06970	COG2197	response regulator
H4F70_RS06980	COG3631	Ketosteroid isomerase-related protein
H4F70_RS06995	COG2197	response regulator
H4F70_RS07020	COG0535	radical SAM domain protein
H4F70_RS07045	COG1388	LysM domain
H4F70_RS07105	COG1960	acyl-CoA dehydrogenase activity
H4F70_RS07110	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4F70_RS07120	COG0183	Belongs to the thiolase family
H4F70_RS07125	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4F70_RS07125	COG1024	Enoyl-CoA hydratase
H4F70_RS07170	COG2072	flavoprotein involved in K transport
H4F70_RS07180	COG1061	Type III restriction enzyme res subunit
H4F70_RS07255	COG2814	Major facilitator Superfamily
H4F70_RS07275	COG2252	PERMEase
H4F70_RS07300	COG1960	acyl-CoA dehydrogenase activity
H4F70_RS07310	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H4F70_RS07325	COG0545	Peptidyl-prolyl cis-trans isomerase
H4F70_RS07340	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H4F70_RS07340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H4F70_RS07355	COG0831	urea catabolic process
H4F70_RS07360	COG0832	Belongs to the urease beta subunit family
H4F70_RS07365	COG0804	urea catabolic process
H4F70_RS07375	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H4F70_RS07380	COG0829	nickel cation binding
H4F70_RS07390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4F70_RS07395	COG0601	transmembrane transport
H4F70_RS07415	COG1012	belongs to the aldehyde dehydrogenase family
H4F70_RS07420	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H4F70_RS07425	COG3540	Alkaline phosphatase
H4F70_RS07475	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H4F70_RS07490	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H4F70_RS07500	COG2272	Belongs to the type-B carboxylesterase lipase family
H4F70_RS07520	COG0598	Magnesium transport protein CorA
H4F70_RS07640	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H4F70_RS07650	COG3409	Peptidoglycan-binding domain 1 protein
H4F70_RS07650	COG3757	hydrolase, family 25
H4F70_RS07665	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H4F70_RS07670	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H4F70_RS07675	COG0166	Belongs to the GPI family
H4F70_RS07705	COG0739	heme binding
H4F70_RS07710	COG0045	succinate-CoA ligase (ADP-forming) activity
H4F70_RS07740	COG2409	Drug exporters of the RND superfamily
H4F70_RS07745	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
H4F70_RS07760	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H4F70_RS07765	COG2860	membrane
H4F70_RS07770	COG0745	RESPONSE REGULATOR receiver
H4F70_RS07775	COG2205	protein histidine kinase activity
H4F70_RS07780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4F70_RS07785	COG0315	cyclic pyranopterin monophosphate synthase activity
H4F70_RS07785	COG0521	Mo-molybdopterin cofactor biosynthetic process
H4F70_RS07805	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H4F70_RS07810	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H4F70_RS07820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4F70_RS07855	COG0739	heme binding
H4F70_RS07870	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS07930	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4F70_RS07935	COG0084	hydrolase, TatD family'
H4F70_RS07940	COG3583	domain protein
H4F70_RS07950	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H4F70_RS07960	COG1024	Enoyl-CoA hydratase
H4F70_RS07970	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H4F70_RS07980	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H4F70_RS08000	COG1393	Belongs to the ArsC family
H4F70_RS08015	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H4F70_RS08020	COG0121	glutamine amidotransferase
H4F70_RS08025	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
H4F70_RS08050	COG2188	Transcriptional regulator
H4F70_RS08055	COG1119	ATPase activity
H4F70_RS08100	COG1309	transcriptional regulator
H4F70_RS08110	COG3956	TIGRFAM MazG family protein
H4F70_RS08125	COG2175	clavaminate synthase activity
H4F70_RS08135	COG0148	phosphopyruvate hydratase activity
H4F70_RS08205	COG2801	Transposase and inactivated derivatives
H4F70_RS08220	COG2135	peptidase activity
H4F70_RS08230	COG0183	Belongs to the thiolase family
H4F70_RS08235	COG2755	lipolytic protein G-D-S-L family
H4F70_RS08275	COG1131	(ABC) transporter
H4F70_RS08280	COG3559	Exporter of polyketide antibiotics
H4F70_RS08300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H4F70_RS08305	COG0653	protein targeting
H4F70_RS08355	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H4F70_RS08365	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H4F70_RS08370	COG1331	Highly conserved protein containing a thioredoxin domain
H4F70_RS08390	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H4F70_RS08400	COG1063	alcohol dehydrogenase
H4F70_RS08420	COG1072	(Pantothenic acid kinase))
H4F70_RS08430	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H4F70_RS08450	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H4F70_RS08465	COG1218	3'(2'),5'-bisphosphate nucleotidase
H4F70_RS08530	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H4F70_RS08540	COG1322	Protein conserved in bacteria
H4F70_RS08545	COG0420	3'-5' exonuclease activity
H4F70_RS08550	COG0419	ATPase involved in DNA repair
H4F70_RS08555	COG0628	permease
H4F70_RS08560	COG0038	chloride channel
H4F70_RS08565	COG0012	GTP binding
H4F70_RS08570	COG3328	transposase activity
H4F70_RS08640	COG1487	ribonuclease activity
H4F70_RS08650	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H4F70_RS08655	COG0477	Major facilitator Superfamily
H4F70_RS08675	COG0494	nUDIX hydrolase
H4F70_RS08700	COG1716	ATPase activity
H4F70_RS08700	COG0842	Transport permease protein
H4F70_RS08700	COG1131	(ABC) transporter
H4F70_RS08715	COG2066	Belongs to the glutaminase family
H4F70_RS08730	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4F70_RS08740	COG0649	NAD binding
H4F70_RS08750	COG1034	ATP synthesis coupled electron transport
H4F70_RS08755	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H4F70_RS08795	COG1073	alpha beta
H4F70_RS08805	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H4F70_RS08805	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H4F70_RS08850	COG2154	pterin-4-alpha-carbinolamine dehydratase
H4F70_RS08865	COG3842	ATPase activity
H4F70_RS08875	COG0747	negative chemotaxis
H4F70_RS08880	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H4F70_RS08900	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
H4F70_RS08920	COG0318	PFAM AMP-dependent synthetase and ligase
H4F70_RS08925	COG3467	pyridoxamine 5'-phosphate
H4F70_RS08930	COG2365	Tyrosine phosphatase family
H4F70_RS08945	COG1309	transcriptional regulator
H4F70_RS08955	COG1113	amino acid transport
H4F70_RS08965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H4F70_RS08970	COG1611	Belongs to the LOG family
H4F70_RS08975	COG1611	Belongs to the LOG family
H4F70_RS08980	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H4F70_RS08985	COG0463	Glycosyl transferase, family 2
H4F70_RS09005	COG4122	O-methyltransferase activity
H4F70_RS09020	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H4F70_RS09040	COG2239	Acts as a magnesium transporter
H4F70_RS09055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H4F70_RS09065	COG0613	PHP domain protein
H4F70_RS09100	COG1309	transcriptional regulator
H4F70_RS09105	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4F70_RS09105	COG0567	Dehydrogenase, E1 component
H4F70_RS09110	COG1132	(ABC) transporter
H4F70_RS09160	COG1960	acyl-CoA dehydrogenase activity
H4F70_RS09180	COG2272	Belongs to the type-B carboxylesterase lipase family
H4F70_RS09185	COG3757	hydrolase, family 25
H4F70_RS09215	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H4F70_RS09230	COG0477	Major facilitator Superfamily
H4F70_RS09240	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4F70_RS09245	COG0022	dehydrogenase e1 component
H4F70_RS09270	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H4F70_RS09275	COG4279	zinc finger
H4F70_RS09280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4F70_RS09295	COG0018	arginyl-trna synthetase
H4F70_RS09300	COG0019	diaminopimelate decarboxylase activity
H4F70_RS09305	COG0460	homoserine dehydrogenase
H4F70_RS09310	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H4F70_RS09315	COG0083	homoserine kinase activity
H4F70_RS09320	COG0318	PFAM AMP-dependent synthetase and ligase
H4F70_RS09330	COG0254	rRNA binding
H4F70_RS09335	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H4F70_RS09340	COG2890	protein-(glutamine-N5) methyltransferase activity
H4F70_RS09360	COG0356	it plays a direct role in the translocation of protons across the membrane
H4F70_RS09365	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H4F70_RS09370	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H4F70_RS09375	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H4F70_RS09385	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H4F70_RS09390	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H4F70_RS09435	COG0647	UMP catabolic process
H4F70_RS09470	COG0504	CTP synthase activity
H4F70_RS09490	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H4F70_RS09495	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H4F70_RS09505	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H4F70_RS09510	COG1160	GTP binding
H4F70_RS09525	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H4F70_RS09555	COG1716	ATPase activity
H4F70_RS09585	COG1253	flavin adenine dinucleotide binding
H4F70_RS09600	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H4F70_RS09620	COG1252	NADH dehydrogenase
H4F70_RS09670	COG2175	clavaminate synthase activity
H4F70_RS09675	COG3246	L-lysine catabolic process to acetate
H4F70_RS09690	COG0318	PFAM AMP-dependent synthetase and ligase
H4F70_RS09705	COG4948	Mandelate Racemase Muconate Lactonizing
H4F70_RS09750	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H4F70_RS09760	COG0028	Belongs to the TPP enzyme family
H4F70_RS09765	COG0277	FAD linked oxidase domain protein
H4F70_RS09765	COG0247	lactate metabolic process
H4F70_RS09775	COG2271	Major facilitator Superfamily
H4F70_RS09785	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS09845	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS09850	COG5285	phytanoyl-CoA dioxygenase
H4F70_RS09860	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H4F70_RS09925	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H4F70_RS09970	COG1012	belongs to the aldehyde dehydrogenase family
H4F70_RS09980	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
H4F70_RS09985	COG0693	protein deglycase activity
H4F70_RS10020	COG2890	protein-(glutamine-N5) methyltransferase activity
H4F70_RS10035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4F70_RS10045	COG0069	glutamate synthase activity
H4F70_RS10050	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H4F70_RS10075	COG2239	Acts as a magnesium transporter
H4F70_RS10095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4F70_RS10100	COG0300	oxidoreductase activity
H4F70_RS10155	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
H4F70_RS10210	COG0646	methionine synthase
H4F70_RS10210	COG1410	methionine synthase
H4F70_RS10220	COG0215	cysteine-tRNA ligase activity
H4F70_RS10240	COG0667	Aldo Keto reductase
H4F70_RS10255	COG4558	Periplasmic binding protein
H4F70_RS10260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4F70_RS10265	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H4F70_RS10305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H4F70_RS10370	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H4F70_RS10375	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS10380	COG2304	oxidoreductase activity
H4F70_RS10390	COG0714	Associated with various cellular activities
H4F70_RS10395	COG3883	PFAM NLP P60 protein
H4F70_RS10395	COG0791	NLP P60 protein
H4F70_RS10405	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H4F70_RS10410	COG1309	transcriptional regulator
H4F70_RS10415	COG0488	(ABC) transporter
H4F70_RS10425	COG0644	oxidoreductase
H4F70_RS10430	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H4F70_RS10440	COG2151	metal-sulfur cluster biosynthetic enzyme
H4F70_RS10445	COG0822	iron-sulfur transferase activity
H4F70_RS10455	COG0396	ATPase activity
H4F70_RS10480	COG1131	(ABC) transporter
H4F70_RS10500	COG0109	protoheme IX farnesyltransferase activity
H4F70_RS10510	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H4F70_RS10540	COG0149	triose-phosphate isomerase activity
H4F70_RS10545	COG0126	phosphoglycerate kinase activity
H4F70_RS10550	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H4F70_RS10585	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H4F70_RS10585	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H4F70_RS10625	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H4F70_RS10640	COG0194	GDP metabolic process
H4F70_RS10665	COG0505	Belongs to the CarA family
H4F70_RS10685	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H4F70_RS10690	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H4F70_RS10695	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H4F70_RS10700	COG0006	proline dipeptidase activity
H4F70_RS10725	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H4F70_RS10735	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H4F70_RS10740	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H4F70_RS10745	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H4F70_RS10760	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H4F70_RS10775	COG0028	Belongs to the TPP enzyme family
H4F70_RS10780	COG2376	Dihydroxyacetone kinase
H4F70_RS10790	COG1283	sodium-dependent phosphate transmembrane transporter activity
H4F70_RS10800	COG0095	Lipoate-protein ligase
H4F70_RS10825	COG1501	Belongs to the glycosyl hydrolase 31 family
H4F70_RS10840	COG1570	exodeoxyribonuclease VII activity
H4F70_RS10855	COG3848	Pyruvate phosphate dikinase
H4F70_RS10855	COG0574	Belongs to the PEP-utilizing enzyme family
H4F70_RS10860	COG1073	alpha beta
H4F70_RS10880	COG1501	Belongs to the glycosyl hydrolase 31 family
H4F70_RS10900	COG2814	Major facilitator Superfamily
H4F70_RS10910	COG2409	Drug exporters of the RND superfamily
H4F70_RS10920	COG2226	methyltransferase
H4F70_RS10985	COG0653	protein targeting
H4F70_RS10995	COG0477	Major facilitator Superfamily
H4F70_RS11005	COG1192	Involved in chromosome partitioning
H4F70_RS11040	COG2826	transposase and inactivated derivatives, IS30 family
H4F70_RS11100	COG0366	Alpha amylase catalytic
H4F70_RS11135	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H4F70_RS11140	COG0318	PFAM AMP-dependent synthetase and ligase
H4F70_RS11145	COG1309	transcriptional regulator
H4F70_RS11160	COG2132	Multicopper oxidase
H4F70_RS11190	COG1024	Enoyl-CoA hydratase
H4F70_RS11195	COG0318	PFAM AMP-dependent synthetase and ligase
H4F70_RS11210	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4F70_RS11225	COG0318	PFAM AMP-dependent synthetase and ligase
H4F70_RS11230	COG0154	amidase activity
H4F70_RS11235	COG0789	Transcriptional regulator
H4F70_RS11235	COG4978	Transcriptional regulator
H4F70_RS11260	COG1234	tRNA 3'-trailer cleavage
H4F70_RS11270	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS11275	COG0183	Belongs to the thiolase family
H4F70_RS11290	COG0346	lactoylglutathione lyase activity
H4F70_RS11295	COG0235	Class ii aldolase
H4F70_RS11305	COG0318	PFAM AMP-dependent synthetase and ligase
H4F70_RS11325	COG1960	acyl-CoA dehydrogenase activity
H4F70_RS11340	COG1309	transcriptional regulator
H4F70_RS11345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4F70_RS11350	COG3548	integral membrane protein
H4F70_RS11365	COG4585	Histidine kinase
H4F70_RS11425	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H4F70_RS11435	COG0640	Transcriptional regulator
H4F70_RS11445	COG3654	unkown
H4F70_RS11465	COG1024	Enoyl-CoA hydratase
H4F70_RS11470	COG0318	PFAM AMP-dependent synthetase and ligase
H4F70_RS11500	COG0124	histidyl-tRNA synthetase
H4F70_RS11505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4F70_RS11515	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H4F70_RS11525	COG0747	negative chemotaxis
H4F70_RS11530	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H4F70_RS11545	COG2255	four-way junction helicase activity
H4F70_RS11550	COG0632	four-way junction helicase activity
H4F70_RS11555	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H4F70_RS11565	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
H4F70_RS11570	COG1946	Acyl-CoA thioesterase
H4F70_RS11575	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
H4F70_RS11585	COG0438	transferase activity, transferring glycosyl groups
H4F70_RS11590	COG1560	Kdo2-lipid A biosynthetic process
H4F70_RS11605	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H4F70_RS11610	COG2318	DinB family
H4F70_RS11650	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H4F70_RS11665	COG3608	succinylglutamate desuccinylase aspartoacylase
H4F70_RS11665	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H4F70_RS11715	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H4F70_RS11730	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H4F70_RS11755	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H4F70_RS11760	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H4F70_RS11765	COG0531	amino acid
H4F70_RS11770	COG0569	domain protein
H4F70_RS11800	COG0756	dUTP diphosphatase activity
H4F70_RS11820	COG0483	inositol monophosphate 1-phosphatase activity
H4F70_RS11835	COG0475	glutathione-regulated potassium exporter activity
H4F70_RS11885	COG0123	including yeast histone deacetylase and acetoin utilization protein
H4F70_RS11945	COG0583	DNA-binding transcription factor activity
H4F70_RS11950	COG0450	alkyl hydroperoxide reductase
H4F70_RS11955	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H4F70_RS11975	COG1129	ABC transporter
H4F70_RS11980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4F70_RS11985	COG1643	Atp-dependent helicase
H4F70_RS11990	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H4F70_RS12000	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H4F70_RS12010	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H4F70_RS12020	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H4F70_RS12025	COG1414	Transcriptional regulator
H4F70_RS12030	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H4F70_RS12040	COG1196	nuclear chromosome segregation
H4F70_RS12050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H4F70_RS12055	COG1126	abc transporter atp-binding protein
H4F70_RS12060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4F70_RS12065	COG0765	amino acid transport
H4F70_RS12075	COG2137	regulation of response to DNA damage stimulus
H4F70_RS12080	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H4F70_RS12100	COG1268	BioY protein
H4F70_RS12105	COG1122	ATPase activity
H4F70_RS12110	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H4F70_RS12120	COG1396	sequence-specific DNA binding
H4F70_RS12135	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H4F70_RS12155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H4F70_RS12180	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H4F70_RS12190	COG1185	polyribonucleotide nucleotidyltransferase activity
H4F70_RS12195	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H4F70_RS12210	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H4F70_RS12225	COG0534	Mate efflux family protein
H4F70_RS12230	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H4F70_RS12265	COG0442	prolyl-tRNA aminoacylation
H4F70_RS12270	COG3022	response to hydroperoxide
H4F70_RS12275	COG1648	precorrin-2 dehydrogenase activity
H4F70_RS12275	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H4F70_RS12280	COG0579	oxidoreductase
H4F70_RS12320	COG0768	penicillin binding
H4F70_RS12340	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H4F70_RS12355	COG5416	Lipopolysaccharide assembly protein A domain
H4F70_RS12365	COG0233	cytoplasmic translational termination
H4F70_RS12370	COG0528	UMP kinase activity
H4F70_RS12375	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H4F70_RS12380	COG0052	Belongs to the universal ribosomal protein uS2 family
H4F70_RS12390	COG4974	Belongs to the 'phage' integrase family
H4F70_RS12410	COG0792	nuclease activity
H4F70_RS12425	COG0681	Belongs to the peptidase S26 family
H4F70_RS12430	COG0335	large ribosomal subunit rRNA binding
H4F70_RS12435	COG2183	response to ionizing radiation
H4F70_RS12440	COG0336	Belongs to the RNA methyltransferase TrmD family
H4F70_RS12455	COG0228	four-way junction DNA binding
H4F70_RS12495	COG1254	Belongs to the acylphosphatase family
H4F70_RS12520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H4F70_RS12525	COG0571	ribonuclease III activity
H4F70_RS12530	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H4F70_RS12550	COG0742	ribosomal rna small subunit methyltransferase
H4F70_RS12555	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H4F70_RS12560	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H4F70_RS12565	COG1461	Dihydroxyacetone kinase
H4F70_RS12570	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H4F70_RS12575	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H4F70_RS12600	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H4F70_RS12610	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H4F70_RS12620	COG0776	regulation of translation
H4F70_RS12625	COG0066	3-isopropylmalate dehydratase activity
H4F70_RS12630	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H4F70_RS12650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H4F70_RS12655	COG0318	PFAM AMP-dependent synthetase and ligase
H4F70_RS12660	COG0179	Fumarylacetoacetate (FAA) hydrolase
H4F70_RS12665	COG0473	3-isopropylmalate dehydrogenase activity
H4F70_RS12680	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H4F70_RS12685	COG0440	acetolactate synthase activity
H4F70_RS12700	COG0129	dihydroxy-acid dehydratase activity
H4F70_RS12715	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H4F70_RS12730	COG2197	response regulator
H4F70_RS12735	COG3850	Histidine kinase
H4F70_RS12750	COG0154	amidase activity
H4F70_RS12765	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H4F70_RS12785	COG0482	sulfurtransferase activity
H4F70_RS12795	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H4F70_RS12805	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H4F70_RS12825	COG0110	maltose O-acetyltransferase activity
H4F70_RS12855	COG1119	ATPase activity
H4F70_RS12860	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H4F70_RS12880	COG0183	Belongs to the thiolase family
H4F70_RS12900	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
H4F70_RS12925	COG1017	nitric oxide dioxygenase activity
H4F70_RS12925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H4F70_RS12930	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H4F70_RS12970	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H4F70_RS12985	COG0165	Argininosuccinate lyase
H4F70_RS12995	COG1438	arginine binding
H4F70_RS13000	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H4F70_RS13005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H4F70_RS13010	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H4F70_RS13015	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H4F70_RS13020	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H4F70_RS13025	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4F70_RS13025	COG0072	phenylalanine-tRNA ligase activity
H4F70_RS13030	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H4F70_RS13040	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H4F70_RS13045	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H4F70_RS13060	COG0577	efflux transmembrane transporter activity
H4F70_RS13060	COG1136	(ABC) transporter
H4F70_RS13075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4F70_RS13115	COG0237	dephospho-CoA kinase activity
H4F70_RS13115	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H4F70_RS13125	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H4F70_RS13135	COG0765	amino acid transport
H4F70_RS13140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4F70_RS13160	COG0733	neurotransmitter:sodium symporter activity
H4F70_RS13180	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H4F70_RS13190	COG2226	methyltransferase
H4F70_RS13205	COG1946	Acyl-CoA thioesterase
H4F70_RS13220	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H4F70_RS13225	COG0159	tryptophan synthase activity
H4F70_RS13235	COG0134	indole-3-glycerol-phosphate synthase activity
H4F70_RS13245	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H4F70_RS13260	COG1595	DNA-templated transcription, initiation
H4F70_RS13270	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H4F70_RS13275	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H4F70_RS13285	COG0107	imidazoleglycerol-phosphate synthase activity
H4F70_RS13290	COG0483	inositol monophosphate 1-phosphatase activity
H4F70_RS13295	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H4F70_RS13305	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H4F70_RS13315	COG0131	Imidazoleglycerol-phosphate dehydratase
H4F70_RS13325	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H4F70_RS13415	COG1115	amino acid carrier protein
H4F70_RS13425	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H4F70_RS13430	COG0156	8-amino-7-oxononanoate synthase activity
H4F70_RS13435	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H4F70_RS13450	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS13460	COG0477	Major facilitator Superfamily
H4F70_RS13490	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H4F70_RS13530	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H4F70_RS13540	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H4F70_RS13550	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H4F70_RS13570	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H4F70_RS13590	COG0768	penicillin binding
H4F70_RS13605	COG2001	Belongs to the MraZ family
H4F70_RS13670	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H4F70_RS13685	COG1940	carbohydrate kinase activity
H4F70_RS13695	COG0003	Pfam Anion-transporting ATPase
H4F70_RS13715	COG0438	transferase activity, transferring glycosyl groups
H4F70_RS13730	COG0791	NLP P60 protein
H4F70_RS13745	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H4F70_RS13755	COG1845	cytochrome c oxidase, subunit III
H4F70_RS13775	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4F70_RS13785	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H4F70_RS13795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4F70_RS13815	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H4F70_RS13820	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H4F70_RS13825	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H4F70_RS13830	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H4F70_RS13855	COG0321	lipoyl(octanoyl) transferase activity
H4F70_RS13860	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H4F70_RS13875	COG0174	glutamine synthetase
H4F70_RS13885	COG3093	addiction module antidote protein HigA
H4F70_RS13895	COG1174	glycine betaine transport
H4F70_RS13905	COG1174	glycine betaine transport
H4F70_RS13920	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H4F70_RS13925	COG0174	glutamine synthetase
H4F70_RS13930	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H4F70_RS13955	COG1579	Zn-ribbon protein possibly nucleic acid-binding
H4F70_RS14015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H4F70_RS14050	COG2814	Major facilitator Superfamily
H4F70_RS14125	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H4F70_RS14140	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H4F70_RS14145	COG1687	branched-chain amino acid
H4F70_RS14150	COG2197	response regulator
H4F70_RS14155	COG4585	Histidine kinase
H4F70_RS14165	COG1131	(ABC) transporter
H4F70_RS14190	COG0423	glycine-tRNA ligase activity
H4F70_RS14210	COG2066	Belongs to the glutaminase family
H4F70_RS14215	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H4F70_RS14220	COG1381	Involved in DNA repair and RecF pathway recombination
H4F70_RS14245	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H4F70_RS14260	COG0484	heat shock protein binding
H4F70_RS14265	COG1420	regulation of RNA biosynthetic process
H4F70_RS14280	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H4F70_RS14285	COG0175	sulfate reduction
H4F70_RS14310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H4F70_RS14325	COG3387	PFAM Glycoside hydrolase 15-related
H4F70_RS14330	COG2070	2-Nitropropane dioxygenase
H4F70_RS14335	COG0481	GTPase activity
H4F70_RS14340	COG0268	Binds directly to 16S ribosomal RNA
H4F70_RS14355	COG1555	photosystem II stabilization
H4F70_RS14355	COG1596	polysaccharide export
H4F70_RS14365	COG2755	lipolytic protein G-D-S-L family
H4F70_RS14370	COG0406	alpha-ribazole phosphatase activity
H4F70_RS14380	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H4F70_RS14390	COG0542	response to heat
H4F70_RS14395	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H4F70_RS14400	COG3268	Saccharopine dehydrogenase
H4F70_RS14405	COG0514	ATP-dependent DNA helicase (RecQ)
H4F70_RS14410	COG0456	acetyltransferase
H4F70_RS14415	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H4F70_RS14420	COG1917	Cupin 2, conserved barrel domain protein
H4F70_RS14450	COG2608	mercury ion transmembrane transporter activity
H4F70_RS14490	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H4F70_RS14505	COG1530	ribonuclease E activity
H4F70_RS14505	COG1530	ribonuclease E activity
H4F70_RS14520	COG0285	dihydrofolate synthase activity
H4F70_RS14525	COG0525	valine-tRNA ligase activity
H4F70_RS14540	COG0746	molybdenum cofactor guanylyltransferase activity
H4F70_RS14550	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H4F70_RS14560	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H4F70_RS14575	COG3485	protocatechuate 3,4-dioxygenase
H4F70_RS14605	COG1454	alcohol dehydrogenase
H4F70_RS14610	COG1234	tRNA 3'-trailer cleavage
H4F70_RS14615	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H4F70_RS14615	COG1116	anion transmembrane transporter activity
H4F70_RS14620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4F70_RS14625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4F70_RS14630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H4F70_RS14635	COG0583	DNA-binding transcription factor activity
H4F70_RS14685	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H4F70_RS14690	COG1414	Transcriptional regulator
H4F70_RS14710	COG0740	serine-type endopeptidase activity
H4F70_RS14715	COG0740	serine-type endopeptidase activity
H4F70_RS14720	COG0544	peptidyl-prolyl cis-trans isomerase activity
H4F70_RS14750	COG0517	IMP dehydrogenase activity
H4F70_RS14750	COG4175	Glycine betaine
H4F70_RS14770	COG0114	fumarate hydratase activity
H4F70_RS14800	COG4974	Belongs to the 'phage' integrase family
H4F70_RS14805	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H4F70_RS14810	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H4F70_RS14850	COG2902	Dehydrogenase
H4F70_RS14895	COG5285	phytanoyl-CoA dioxygenase
H4F70_RS14905	COG1902	pentaerythritol trinitrate reductase activity
H4F70_RS14905	COG0446	pyridine nucleotide-disulphide oxidoreductase
H4F70_RS14925	COG0300	oxidoreductase activity
H4F70_RS14930	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H4F70_RS14940	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H4F70_RS14950	COG1376	ErfK ybiS ycfS ynhG family protein
H4F70_RS15010	COG1475	DNA binding
H4F70_RS15075	COG2176	DNA-directed DNA polymerase activity
H4F70_RS15215	COG0739	heme binding
H4F70_RS15285	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H4F70_RS15325	COG1136	(ABC) transporter
H4F70_RS15340	COG2197	response regulator
H4F70_RS15360	COG2030	dehydratase
H4F70_RS15365	COG5504	Zn-dependent protease
H4F70_RS15370	COG0477	Major facilitator Superfamily
H4F70_RS15405	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H4F70_RS15410	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H4F70_RS15440	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H4F70_RS15445	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H4F70_RS15450	COG1335	isochorismatase
H4F70_RS15470	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H4F70_RS15495	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H4F70_RS15500	COG0456	acetyltransferase
H4F70_RS15520	COG2267	carboxylic ester hydrolase activity
H4F70_RS15535	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H4F70_RS15540	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H4F70_RS15545	COG0569	domain protein
H4F70_RS15550	COG0583	DNA-binding transcription factor activity
H4F70_RS15560	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS15615	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H4F70_RS15620	COG2177	Part of the ABC transporter FtsEX involved in
H4F70_RS15625	COG2884	Cell division ATP-binding protein ftsE
H4F70_RS15630	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H4F70_RS15635	COG0483	inositol monophosphate 1-phosphatase activity
H4F70_RS15645	COG1960	acyl-CoA dehydrogenase activity
H4F70_RS15655	COG0488	(ABC) transporter
H4F70_RS15660	COG0318	PFAM AMP-dependent synthetase and ligase
H4F70_RS15680	COG1615	UPF0182 protein
H4F70_RS15690	COG3480	Lon protease (S16) C-terminal proteolytic domain
H4F70_RS15710	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H4F70_RS15730	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H4F70_RS15735	COG0210	DNA helicase
H4F70_RS15745	COG0596	Alpha beta hydrolase
H4F70_RS15760	COG2186	Transcriptional regulator
H4F70_RS15800	COG0513	Belongs to the DEAD box helicase family
H4F70_RS15815	COG0406	alpha-ribazole phosphatase activity
H4F70_RS15835	COG1597	lipid kinase activity
H4F70_RS15860	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H4F70_RS15865	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H4F70_RS15870	COG1162	GTPase activity
H4F70_RS15875	COG2124	cytochrome p450
H4F70_RS15880	COG0183	Belongs to the thiolase family
H4F70_RS15890	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS15895	COG1024	Enoyl-CoA hydratase
H4F70_RS15910	COG2070	2-Nitropropane dioxygenase
H4F70_RS15920	COG0183	Belongs to the thiolase family
H4F70_RS15925	COG1309	transcriptional regulator
H4F70_RS15930	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS15935	COG1960	acyl-CoA dehydrogenase activity
H4F70_RS15940	COG0318	PFAM AMP-dependent synthetase and ligase
H4F70_RS15945	COG1960	acyl-CoA dehydrogenase activity
H4F70_RS15950	COG1960	acyl-CoA dehydrogenase activity
H4F70_RS15955	COG1960	acyl-CoA dehydrogenase activity
H4F70_RS15960	COG0596	Alpha beta hydrolase
H4F70_RS15975	COG0657	acetylesterase activity
H4F70_RS15980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4F70_RS15990	COG1960	acyl-CoA dehydrogenase activity
H4F70_RS16005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H4F70_RS16015	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
H4F70_RS16025	COG1053	succinate dehydrogenase
H4F70_RS16030	COG2030	dehydratase
H4F70_RS16050	COG0730	response to heat
H4F70_RS16085	COG1136	(ABC) transporter
H4F70_RS16125	COG1960	acyl-CoA dehydrogenase activity
H4F70_RS16130	COG1960	acyl-CoA dehydrogenase activity
H4F70_RS16135	COG1960	acyl-CoA dehydrogenase activity
H4F70_RS16140	COG1309	transcriptional regulator
H4F70_RS16145	COG3387	PFAM Glycoside hydrolase 15-related
H4F70_RS16155	COG1120	ATPase activity
H4F70_RS16160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H4F70_RS16205	COG0181	hydroxymethylbilane synthase activity
H4F70_RS16210	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H4F70_RS16275	COG0745	RESPONSE REGULATOR receiver
H4F70_RS16285	COG0588	phosphoglycerate mutase activity
H4F70_RS16295	COG0438	transferase activity, transferring glycosyl groups
H4F70_RS16310	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H4F70_RS16325	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H4F70_RS16335	COG2267	carboxylic ester hydrolase activity
H4F70_RS16340	COG0789	Transcriptional regulator
H4F70_RS16365	COG2733	membrane
H4F70_RS16390	COG2224	Isocitrate lyase
H4F70_RS16405	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS16460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4F70_RS16465	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H4F70_RS16555	COG0803	Belongs to the bacterial solute-binding protein 9 family
H4F70_RS16560	COG1121	(ABC) transporter
H4F70_RS16565	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H4F70_RS16605	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS16610	COG1505	serine-type exopeptidase activity
H4F70_RS16625	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H4F70_RS16640	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H4F70_RS16640	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H4F70_RS16650	COG4942	peptidase
H4F70_RS16675	COG5343	regulation of RNA biosynthetic process
H4F70_RS16680	COG1595	DNA-templated transcription, initiation
H4F70_RS16695	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H4F70_RS16700	COG2161	toxin-antitoxin pair type II binding
H4F70_RS16715	COG2409	Drug exporters of the RND superfamily
H4F70_RS16730	COG0415	Belongs to the DNA photolyase family
H4F70_RS16760	COG0647	UMP catabolic process
H4F70_RS16800	COG0688	phosphatidylethanolamine metabolic process
H4F70_RS16830	COG0204	Acyl-transferase
H4F70_RS16830	COG0318	PFAM AMP-dependent synthetase and ligase
H4F70_RS16885	COG1674	ftsk spoiiie
H4F70_RS16895	COG1404	Belongs to the peptidase S8 family
H4F70_RS16925	COG2111	Na H antiporter
H4F70_RS16925	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H4F70_RS17015	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H4F70_RS17020	COG0351	phosphomethylpyrimidine kinase
H4F70_RS17040	COG1131	(ABC) transporter
H4F70_RS17045	COG2022	thiamine diphosphate biosynthetic process
H4F70_RS17065	COG2267	carboxylic ester hydrolase activity
H4F70_RS17080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4F70_RS17095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4F70_RS17120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4F70_RS17130	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
H4F70_RS17135	COG1120	ATPase activity
H4F70_RS17140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4F70_RS17145	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H4F70_RS17170	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4F70_RS17190	COG1535	isochorismatase
H4F70_RS17190	COG3433	isochorismatase activity
H4F70_RS17195	COG1169	isochorismate synthase
H4F70_RS17200	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS17205	COG2382	esterase
H4F70_RS17210	COG1120	ATPase activity
H4F70_RS17215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4F70_RS17220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4F70_RS17230	COG1021	2,3-dihydroxybenzoate-AMP ligase
H4F70_RS17235	COG1535	isochorismatase
H4F70_RS17235	COG3433	isochorismatase activity
H4F70_RS17240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H4F70_RS17245	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H4F70_RS17255	COG1994	Peptidase M50
H4F70_RS17260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4F70_RS17270	COG0791	NLP P60 protein
H4F70_RS17280	COG2814	Major facilitator Superfamily
H4F70_RS17350	COG1797	cobyrinic acid a,c-diamide synthase activity
H4F70_RS17355	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H4F70_RS17365	COG2124	cytochrome p450
H4F70_RS17370	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS17410	COG0318	PFAM AMP-dependent synthetase and ligase
H4F70_RS17415	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H4F70_RS17425	COG1309	transcriptional regulator
H4F70_RS17430	COG2072	flavoprotein involved in K transport
H4F70_RS17450	COG1492	cobalamin metabolic process
H4F70_RS17465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4F70_RS17470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4F70_RS17475	COG1120	ATPase activity
H4F70_RS17495	COG0586	Pfam SNARE associated Golgi protein
H4F70_RS17500	COG0586	Pfam SNARE associated Golgi protein
H4F70_RS17550	COG0542	response to heat
H4F70_RS17570	COG0252	asparaginase activity
H4F70_RS17575	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS17580	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS17590	COG1609	Transcriptional regulator
H4F70_RS17595	COG0318	PFAM AMP-dependent synthetase and ligase
H4F70_RS17630	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H4F70_RS17635	COG0798	PFAM Bile acid sodium symporter
H4F70_RS17640	COG0640	Transcriptional regulator
H4F70_RS17650	COG4585	Histidine kinase
H4F70_RS17665	COG0789	Transcriptional regulator
H4F70_RS17670	COG0484	heat shock protein binding
H4F70_RS17675	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H4F70_RS17680	COG0443	Heat shock 70 kDa protein
H4F70_RS17700	COG2181	nitrate reductase activity
H4F70_RS17700	COG0247	lactate metabolic process
H4F70_RS17705	COG2197	response regulator
H4F70_RS17735	COG0586	Pfam SNARE associated Golgi protein
H4F70_RS17775	COG3408	Glycogen debranching enzyme
H4F70_RS17775	COG3119	arylsulfatase activity
H4F70_RS17780	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H4F70_RS17785	COG0656	L-ascorbic acid biosynthetic process
H4F70_RS17805	COG4115	mRNA cleavage
H4F70_RS17810	COG2161	toxin-antitoxin pair type II binding
H4F70_RS17820	COG0435	Glutathione S-transferase
H4F70_RS17825	COG0500	methyltransferase
H4F70_RS17830	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4F70_RS17850	COG1309	transcriptional regulator
H4F70_RS17860	COG1960	acyl-CoA dehydrogenase activity
H4F70_RS17865	COG3842	ATPase activity
H4F70_RS17910	COG0183	Belongs to the thiolase family
H4F70_RS17925	COG1309	transcriptional regulator
H4F70_RS17930	COG1472	Belongs to the glycosyl hydrolase 3 family
H4F70_RS17935	COG0589	response to stress
H4F70_RS17950	COG4981	capsule polysaccharide biosynthetic process
H4F70_RS17985	COG0500	methyltransferase
H4F70_RS17995	COG0500	methyltransferase
H4F70_RS18020	COG1024	Enoyl-CoA hydratase
H4F70_RS18025	COG1741	Belongs to the pirin family
H4F70_RS18030	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
H4F70_RS18035	COG2267	carboxylic ester hydrolase activity
H4F70_RS18055	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H4F70_RS18065	COG2409	Drug exporters of the RND superfamily
H4F70_RS18080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H4F70_RS18090	COG3012	SEC-C Motif Domain Protein
H4F70_RS18095	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H4F70_RS18150	COG2353	YceI-like domain
H4F70_RS18160	COG3104	oligopeptide transport
H4F70_RS18165	COG2855	membrane
H4F70_RS18170	COG0583	DNA-binding transcription factor activity
H4F70_RS18180	COG0626	cystathionine gamma-synthase activity
H4F70_RS18205	COG3590	peptidase
H4F70_RS18210	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H4F70_RS18240	COG1376	ErfK ybiS ycfS ynhG family protein
H4F70_RS18245	COG0657	acetylesterase activity
H4F70_RS18250	COG0277	FAD linked oxidase domain protein
H4F70_RS18255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4F70_RS18260	COG0129	dihydroxy-acid dehydratase activity
H4F70_RS18270	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H4F70_RS18295	COG0477	Major facilitator Superfamily
H4F70_RS18300	COG3265	gluconokinase activity
H4F70_RS18310	COG2176	DNA-directed DNA polymerase activity
H4F70_RS18310	COG5002	protein histidine kinase activity
H4F70_RS18320	COG1960	acyl-CoA dehydrogenase activity
H4F70_RS18325	COG0318	PFAM AMP-dependent synthetase and ligase
H4F70_RS18335	COG1024	Enoyl-CoA hydratase
H4F70_RS18340	COG0564	pseudouridine synthase activity
H4F70_RS18360	COG1473	amidohydrolase
H4F70_RS18360	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H4F70_RS18395	COG2258	MOSC domain
H4F70_RS18405	COG2015	COG2015, Alkyl sulfatase and related hydrolases
H4F70_RS18410	COG2197	response regulator
H4F70_RS18440	COG1960	acyl-CoA dehydrogenase activity
H4F70_RS18460	COG0667	Aldo Keto reductase
H4F70_RS18475	COG0477	Major facilitator Superfamily
H4F70_RS18520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4F70_RS18525	COG0748	coenzyme F420 binding
H4F70_RS18530	COG1960	acyl-CoA dehydrogenase activity
H4F70_RS18535	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4F70_RS18560	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS18565	COG1902	pentaerythritol trinitrate reductase activity
H4F70_RS18565	COG0446	pyridine nucleotide-disulphide oxidoreductase
H4F70_RS18575	COG0300	oxidoreductase activity
H4F70_RS18580	COG0346	lactoylglutathione lyase activity
H4F70_RS18590	COG0300	oxidoreductase activity
H4F70_RS18605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H4F70_RS18610	COG1584	GPR1 FUN34 yaaH family protein
H4F70_RS18615	COG2814	Major facilitator Superfamily
H4F70_RS18625	COG1388	LysM domain
H4F70_RS18630	COG3835	regulator
H4F70_RS18635	COG0318	PFAM AMP-dependent synthetase and ligase
H4F70_RS18655	COG4608	Belongs to the ABC transporter superfamily
H4F70_RS18670	COG0601	transmembrane transport
H4F70_RS18680	COG1960	acyl-CoA dehydrogenase activity
H4F70_RS18690	COG2015	COG2015, Alkyl sulfatase and related hydrolases
H4F70_RS18715	COG0318	PFAM AMP-dependent synthetase and ligase
H4F70_RS18730	COG0326	Molecular chaperone. Has ATPase activity
H4F70_RS18745	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H4F70_RS18835	COG1053	succinate dehydrogenase
H4F70_RS18870	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H4F70_RS18875	COG0318	PFAM AMP-dependent synthetase and ligase
H4F70_RS18880	COG4770	biotin carboxylase activity
H4F70_RS18890	COG1131	(ABC) transporter
H4F70_RS18930	COG0477	Major facilitator Superfamily
H4F70_RS18940	COG4585	Histidine kinase
H4F70_RS18945	COG2197	response regulator
H4F70_RS18965	COG0477	Major facilitator Superfamily
H4F70_RS18970	COG0247	lactate metabolic process
H4F70_RS18975	COG1139	Iron-sulfur cluster binding protein
H4F70_RS18980	COG1556	Lactate utilization protein
H4F70_RS19035	COG1024	Enoyl-CoA hydratase
H4F70_RS19040	COG0024	Methionine aminopeptidase
H4F70_RS19050	COG3304	Inner membrane component domain
H4F70_RS19065	COG1252	NADH dehydrogenase
H4F70_RS19070	COG1846	Transcriptional regulator
H4F70_RS19080	COG0477	Major facilitator Superfamily
H4F70_RS19085	COG0477	Major facilitator Superfamily
H4F70_RS19120	COG0842	Transport permease protein
H4F70_RS19185	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H4F70_RS19220	COG0446	pyridine nucleotide-disulphide oxidoreductase
H4F70_RS19220	COG1902	pentaerythritol trinitrate reductase activity
H4F70_RS19235	COG2130	NADP-dependent
H4F70_RS19255	COG2217	Heavy metal translocating P-type atpase
H4F70_RS19265	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
H4F70_RS19275	COG1024	Enoyl-CoA hydratase
H4F70_RS19275	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4F70_RS19300	COG1024	Enoyl-CoA hydratase
H4F70_RS19305	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS19315	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS19325	COG1120	ATPase activity
H4F70_RS19330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4F70_RS19340	COG1960	acyl-CoA dehydrogenase activity
H4F70_RS19365	COG0318	PFAM AMP-dependent synthetase and ligase
H4F70_RS19370	COG2130	NADP-dependent
H4F70_RS19395	COG0318	PFAM AMP-dependent synthetase and ligase
H4F70_RS19435	COG1278	Cold shock
H4F70_RS19460	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H4F70_RS19495	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H4F70_RS19505	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H4F70_RS19530	COG2837	iron assimilation
H4F70_RS19535	COG2822	iron ion transport
H4F70_RS19540	COG0672	)-iron permease
H4F70_RS19545	COG0671	phosphoesterase, PA-phosphatase related
H4F70_RS19575	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H4F70_RS19580	COG0778	Nitroreductase
H4F70_RS19605	COG1053	succinate dehydrogenase
H4F70_RS19660	COG2175	clavaminate synthase activity
H4F70_RS19695	COG1012	belongs to the aldehyde dehydrogenase family
H4F70_RS19705	COG1012	belongs to the aldehyde dehydrogenase family
H4F70_RS19710	COG1028	Short-chain dehydrogenase reductase Sdr
H4F70_RS19725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H4F70_RS19755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4F70_RS19770	COG1309	transcriptional regulator
H4F70_RS19775	COG0667	Aldo Keto reductase
H4F70_RS19800	COG0359	binds to the 23S rRNA
H4F70_RS19805	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H4F70_RS19850	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H4F70_RS19860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H4F70_RS19870	COG1695	Transcriptional regulator
H4F70_RS19875	COG1260	myo-inositol-1-phosphate synthase
H4F70_RS19925	COG3842	ATPase activity
H4F70_RS19965	COG2814	Major facilitator Superfamily
H4F70_RS19970	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4F70_RS19975	COG4221	oxidoreductase activity
H4F70_RS19995	COG3631	Ketosteroid isomerase-related protein
H4F70_RS20005	COG0495	leucyl-tRNA aminoacylation
H4F70_RS20030	COG1678	Uncharacterized ACR, COG1678
H4F70_RS20045	COG0617	tRNA 3'-terminal CCA addition
H4F70_RS20065	COG1595	DNA-templated transcription, initiation
H4F70_RS20080	COG3118	belongs to the thioredoxin family
H4F70_RS20080	COG0492	ferredoxin-NADP+ reductase activity
H4F70_RS20085	COG0860	N-Acetylmuramoyl-L-alanine amidase
H4F70_RS20085	COG3409	Peptidoglycan-binding domain 1 protein
H4F70_RS20105	COG1192	Involved in chromosome partitioning
H4F70_RS20110	COG0357	Ribosomal RNA small subunit methyltransferase G
H4F70_RS20120	COG0706	membrane insertase activity
H4F70_RS20125	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H4F70_RS20130	COG0594	ribonuclease P activity