locus-tag	class	description
FO059_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FO059_RS00010	COG0592	DNA-directed DNA polymerase activity
FO059_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
FO059_RS00025	COG0187	DNA topoisomerase II activity
FO059_RS00035	COG2030	dehydratase
FO059_RS00035	COG1012	belongs to the aldehyde dehydrogenase family
FO059_RS00040	COG2267	carboxylic ester hydrolase activity
FO059_RS00050	COG2146	nitrite reductase [NAD(P)H] activity
FO059_RS00050	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FO059_RS00055	COG2146	nitrite reductase [NAD(P)H] activity
FO059_RS00055	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FO059_RS00060	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FO059_RS00065	COG0243	molybdopterin cofactor binding
FO059_RS00070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FO059_RS00070	COG1372	Participates in initiation and elongation during chromosome replication
FO059_RS00110	COG2357	RelA SpoT domain protein
FO059_RS00165	COG0477	Major facilitator Superfamily
FO059_RS00175	COG1473	amidohydrolase
FO059_RS00205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FO059_RS00210	COG1309	transcriptional regulator
FO059_RS00225	COG1309	transcriptional regulator
FO059_RS00280	COG2072	flavoprotein involved in K transport
FO059_RS00285	COG0583	DNA-binding transcription factor activity
FO059_RS00290	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FO059_RS00315	COG4101	3-hydroxyanthranilate 3,4-dioxygenase activity
FO059_RS00325	COG0477	Major facilitator Superfamily
FO059_RS00330	COG1234	tRNA 3'-trailer cleavage
FO059_RS00340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FO059_RS00345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FO059_RS00350	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FO059_RS00350	COG1116	anion transmembrane transporter activity
FO059_RS00355	COG3609	addiction module antidote protein, CC2985 family
FO059_RS00360	COG2337	Toxic component of a toxin-antitoxin (TA) module
FO059_RS00375	COG1063	alcohol dehydrogenase
FO059_RS00390	COG1414	Transcriptional regulator
FO059_RS00395	COG3971	2-oxopent-4-enoate hydratase activity
FO059_RS00400	COG4569	acetaldehyde dehydrogenase (acetylating) activity
FO059_RS00405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FO059_RS00415	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FO059_RS00415	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FO059_RS00425	COG2818	Glycosylase
FO059_RS00430	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FO059_RS00465	COG1970	mechanosensitive ion channel activity
FO059_RS00510	COG0515	serine threonine protein kinase
FO059_RS00510	COG2815	serine threonine protein kinase
FO059_RS00515	COG0515	serine threonine protein kinase
FO059_RS00520	COG0768	penicillin binding
FO059_RS00535	COG1716	ATPase activity
FO059_RS00540	COG1716	ATPase activity
FO059_RS00575	COG0477	Major facilitator Superfamily
FO059_RS00590	COG1309	transcriptional regulator
FO059_RS00595	COG2272	Belongs to the type-B carboxylesterase lipase family
FO059_RS00615	COG1024	Enoyl-CoA hydratase
FO059_RS00630	COG0477	Major facilitator Superfamily
FO059_RS00640	COG1218	3'(2'),5'-bisphosphate nucleotidase
FO059_RS00645	COG0175	sulfate reduction
FO059_RS00660	COG1960	acyl-CoA dehydrogenase activity
FO059_RS00665	COG1960	acyl-CoA dehydrogenase activity
FO059_RS00670	COG1960	acyl-CoA dehydrogenase activity
FO059_RS00675	COG0183	Belongs to the thiolase family
FO059_RS00680	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FO059_RS00685	COG0183	Belongs to the thiolase family
FO059_RS00710	COG0747	negative chemotaxis
FO059_RS00725	COG1012	belongs to the aldehyde dehydrogenase family
FO059_RS00770	COG0477	Major facilitator Superfamily
FO059_RS00790	COG0492	ferredoxin-NADP+ reductase activity
FO059_RS00810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FO059_RS00830	COG1012	belongs to the aldehyde dehydrogenase family
FO059_RS00830	COG2030	dehydratase
FO059_RS00835	COG1024	Enoyl-CoA hydratase
FO059_RS00860	COG2175	clavaminate synthase activity
FO059_RS00890	COG1278	Cold shock
FO059_RS00895	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FO059_RS00920	COG0709	Synthesizes selenophosphate from selenide and ATP
FO059_RS00930	COG1921	L-seryl-tRNASec selenium transferase activity
FO059_RS00950	COG0437	4 iron, 4 sulfur cluster binding
FO059_RS00955	COG3383	formate dehydrogenase (NAD+) activity
FO059_RS00955	COG0243	molybdopterin cofactor binding
FO059_RS00960	COG0243	molybdopterin cofactor binding
FO059_RS00960	COG3383	formate dehydrogenase (NAD+) activity
FO059_RS00965	COG2409	Drug exporters of the RND superfamily
FO059_RS00970	COG1309	transcriptional regulator
FO059_RS00985	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FO059_RS01000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FO059_RS01010	COG1012	belongs to the aldehyde dehydrogenase family
FO059_RS01020	COG1113	amino acid transport
FO059_RS01025	COG0596	Alpha beta hydrolase
FO059_RS01050	COG0596	Alpha beta hydrolase
FO059_RS01060	COG0745	RESPONSE REGULATOR receiver
FO059_RS01065	COG2205	protein histidine kinase activity
FO059_RS01070	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
FO059_RS01075	COG1181	Belongs to the D-alanine--D-alanine ligase family
FO059_RS01095	COG1233	COG1233 Phytoene dehydrogenase and related
FO059_RS01130	COG1028	Short-chain dehydrogenase reductase Sdr
FO059_RS01160	COG1960	acyl-CoA dehydrogenase activity
FO059_RS01165	COG1609	Transcriptional regulator
FO059_RS01170	COG0477	Major facilitator Superfamily
FO059_RS01185	COG2409	Drug exporters of the RND superfamily
FO059_RS01190	COG1937	Protein conserved in bacteria
FO059_RS01240	COG2814	Major facilitator Superfamily
FO059_RS01250	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FO059_RS01275	COG1126	abc transporter atp-binding protein
FO059_RS01280	COG0765	amino acid transport
FO059_RS01290	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
FO059_RS01295	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FO059_RS01300	COG3639	organic phosphonate transmembrane transporter activity
FO059_RS01310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FO059_RS01335	COG0346	lactoylglutathione lyase activity
FO059_RS01360	COG0657	acetylesterase activity
FO059_RS01370	COG1028	Short-chain dehydrogenase reductase Sdr
FO059_RS01385	COG0604	alcohol dehydrogenase
FO059_RS01385	COG1028	Short-chain dehydrogenase reductase Sdr
FO059_RS01385	COG3321	synthase
FO059_RS01390	COG1960	acyl-CoA dehydrogenase activity
FO059_RS01410	COG0667	Aldo Keto reductase
FO059_RS01415	COG1028	Short-chain dehydrogenase reductase Sdr
FO059_RS01420	COG1028	Short-chain dehydrogenase reductase Sdr
FO059_RS01425	COG1028	Short-chain dehydrogenase reductase Sdr
FO059_RS01520	COG1028	Short-chain dehydrogenase reductase Sdr
FO059_RS01535	COG1053	succinate dehydrogenase
FO059_RS01555	COG1228	amidohydrolase
FO059_RS01560	COG2072	flavoprotein involved in K transport
FO059_RS01580	COG4552	Acetyltransferase involved in intracellular survival and related
FO059_RS01605	COG1285	pathogenesis
FO059_RS01635	COG0668	transmembrane transport
FO059_RS01665	COG1511	domain protein
FO059_RS01665	COG1511	domain protein
FO059_RS01670	COG0076	glutamate decarboxylase activity
FO059_RS01690	COG1045	serine acetyltransferase
FO059_RS01695	COG0492	ferredoxin-NADP+ reductase activity
FO059_RS01700	COG0070	glutamate synthase
FO059_RS01700	COG0069	glutamate synthase activity
FO059_RS01700	COG0067	glutamate synthase
FO059_RS01710	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
FO059_RS01715	COG2501	S4 domain
FO059_RS01725	COG1028	Short-chain dehydrogenase reductase Sdr
FO059_RS01745	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FO059_RS01765	COG0657	acetylesterase activity
FO059_RS01775	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FO059_RS01815	COG0789	Transcriptional regulator
FO059_RS01820	COG1012	belongs to the aldehyde dehydrogenase family
FO059_RS01870	COG2072	flavoprotein involved in K transport
FO059_RS01895	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FO059_RS01905	COG1472	Belongs to the glycosyl hydrolase 3 family
FO059_RS01910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FO059_RS01915	COG2329	Antibiotic biosynthesis monooxygenase
FO059_RS01920	COG0425	Belongs to the sulfur carrier protein TusA family
FO059_RS01920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FO059_RS01945	COG1316	TRANSCRIPTIONal
FO059_RS01970	COG2130	NADP-dependent
FO059_RS01975	COG0077	Prephenate dehydratase
FO059_RS02020	COG2826	transposase and inactivated derivatives, IS30 family
FO059_RS02030	COG2826	transposase and inactivated derivatives, IS30 family
FO059_RS02040	COG2826	transposase and inactivated derivatives, IS30 family
FO059_RS02050	COG0210	DNA helicase
FO059_RS02115	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FO059_RS02115	COG2146	nitrite reductase [NAD(P)H] activity
FO059_RS02125	COG0561	phosphatase activity
FO059_RS02130	COG2385	sporulation resulting in formation of a cellular spore
FO059_RS02140	COG1216	Glycosyl transferase, family 2
FO059_RS02150	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FO059_RS02155	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FO059_RS02165	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FO059_RS02165	COG5479	isomerase activity
FO059_RS02175	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
FO059_RS02180	COG0318	PFAM AMP-dependent synthetase and ligase
FO059_RS02185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FO059_RS02185	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
FO059_RS02185	COG3321	synthase
FO059_RS02190	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FO059_RS02215	COG1028	Short-chain dehydrogenase reductase Sdr
FO059_RS02220	COG0277	FAD linked oxidase domain protein
FO059_RS02230	COG1216	Glycosyl transferase, family 2
FO059_RS02240	COG1012	belongs to the aldehyde dehydrogenase family
FO059_RS02255	COG1216	Glycosyl transferase, family 2
FO059_RS02295	COG2267	carboxylic ester hydrolase activity
FO059_RS02300	COG0737	Belongs to the 5'-nucleotidase family
FO059_RS02305	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FO059_RS02335	COG0154	amidase activity
FO059_RS02340	COG0287	Prephenate dehydrogenase
FO059_RS02350	COG0590	tRNA wobble adenosine to inosine editing
FO059_RS02360	COG2319	Wd-40 repeat
FO059_RS02360	COG4249	Peptidase C14 caspase catalytic subunit p20
FO059_RS02370	COG1937	Protein conserved in bacteria
FO059_RS02375	COG0343	queuine tRNA-ribosyltransferase activity
FO059_RS02385	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FO059_RS02390	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FO059_RS02410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FO059_RS02420	COG1376	ErfK ybiS ycfS ynhG family protein
FO059_RS02425	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FO059_RS02475	COG1028	Short-chain dehydrogenase reductase Sdr
FO059_RS02485	COG1403	HNH endonuclease
FO059_RS02495	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FO059_RS02505	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FO059_RS02510	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FO059_RS02520	COG1492	cobalamin metabolic process
FO059_RS02525	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FO059_RS02530	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FO059_RS02535	COG0753	catalase activity
FO059_RS02540	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
FO059_RS02560	COG1752	Esterase of the alpha-beta hydrolase superfamily
FO059_RS02575	COG3360	Dodecin
FO059_RS02580	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FO059_RS02585	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FO059_RS02605	COG1408	metallophosphoesterase
FO059_RS02615	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FO059_RS02645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FO059_RS02665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FO059_RS02680	COG0596	Alpha beta hydrolase
FO059_RS02690	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FO059_RS02745	COG1205	dead DEAH box helicase
FO059_RS02745	COG1111	helicase
FO059_RS02760	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FO059_RS02760	COG1754	DNA topoisomerase type I activity
FO059_RS02780	COG0470	DNA polymerase III
FO059_RS02810	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
FO059_RS02815	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FO059_RS02830	COG1131	(ABC) transporter
FO059_RS02840	COG0183	Belongs to the thiolase family
FO059_RS02890	COG0477	Major facilitator Superfamily
FO059_RS02900	COG2027	D-alanyl-D-alanine carboxypeptidase
FO059_RS02910	COG0037	tRNA processing
FO059_RS02925	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FO059_RS02930	COG0302	gtp cyclohydrolase
FO059_RS02965	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FO059_RS02970	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FO059_RS02975	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FO059_RS02985	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FO059_RS03010	COG1764	response to oxidative stress
FO059_RS03030	COG0288	reversible hydration of carbon dioxide
FO059_RS03040	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
FO059_RS03050	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FO059_RS03060	COG1329	Transcriptional regulator
FO059_RS03065	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FO059_RS03065	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FO059_RS03070	COG0215	cysteine-tRNA ligase activity
FO059_RS03080	COG1960	acyl-CoA dehydrogenase activity
FO059_RS03095	COG0406	alpha-ribazole phosphatase activity
FO059_RS03105	COG0785	Cytochrome C biogenesis protein
FO059_RS03115	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FO059_RS03125	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FO059_RS03145	COG0542	response to heat
FO059_RS03235	COG4948	Mandelate Racemase Muconate Lactonizing
FO059_RS03250	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FO059_RS03260	COG2226	methyltransferase
FO059_RS03265	COG0644	oxidoreductase
FO059_RS03270	COG0142	geranyltranstransferase activity
FO059_RS03285	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FO059_RS03290	COG1666	GTP binding
FO059_RS03315	COG2030	dehydratase
FO059_RS03320	COG2030	dehydratase
FO059_RS03340	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FO059_RS03345	COG0081	regulation of translation
FO059_RS03365	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FO059_RS03370	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FO059_RS03420	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FO059_RS03425	COG2062	phosphohistidine phosphatase, SixA
FO059_RS03435	COG0477	Major facilitator Superfamily
FO059_RS03460	COG0183	Belongs to the thiolase family
FO059_RS03470	COG2030	dehydratase
FO059_RS03475	COG1028	Short-chain dehydrogenase reductase Sdr
FO059_RS03480	COG1960	acyl-CoA dehydrogenase activity
FO059_RS03500	COG0604	alcohol dehydrogenase
FO059_RS03535	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FO059_RS03560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FO059_RS03580	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FO059_RS03585	COG0049	tRNA binding
FO059_RS03590	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FO059_RS03595	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FO059_RS03620	COG1302	Protein conserved in bacteria
FO059_RS03625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FO059_RS03640	COG1140	nitrate reductase beta subunit
FO059_RS03660	COG1309	transcriptional regulator
FO059_RS03670	COG1960	acyl-CoA dehydrogenase activity
FO059_RS03685	COG4044	May play a role in the intracellular transport of hydrophobic ligands
FO059_RS03690	COG1309	transcriptional regulator
FO059_RS03695	COG1024	Enoyl-CoA hydratase
FO059_RS03760	COG0051	transcription antitermination factor activity, RNA binding
FO059_RS03770	COG0088	Forms part of the polypeptide exit tunnel
FO059_RS03780	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FO059_RS03785	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FO059_RS03790	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FO059_RS03820	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FO059_RS03825	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FO059_RS03835	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FO059_RS03840	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FO059_RS03845	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FO059_RS03860	COG0200	Binds to the 23S rRNA
FO059_RS03870	COG0563	adenylate kinase activity
FO059_RS03880	COG1490	D-aminoacyl-tRNA deacylase activity
FO059_RS03890	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FO059_RS03895	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FO059_RS03900	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FO059_RS03905	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FO059_RS03915	COG0202	RNA polymerase activity
FO059_RS03925	COG0101	tRNA pseudouridine synthase activity
FO059_RS03935	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FO059_RS03945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FO059_RS03970	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FO059_RS03990	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
FO059_RS04005	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FO059_RS04015	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FO059_RS04030	COG0297	glycogen (starch) synthase activity
FO059_RS04035	COG0438	transferase activity, transferring glycosyl groups
FO059_RS04060	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FO059_RS04065	COG1216	Glycosyl transferase, family 2
FO059_RS04090	COG1316	TRANSCRIPTIONal
FO059_RS04095	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FO059_RS04110	COG0456	acetyltransferase
FO059_RS04115	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FO059_RS04130	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FO059_RS04135	COG0459	protein refolding
FO059_RS04175	COG0516	GMP reductase activity
FO059_RS04210	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FO059_RS04210	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FO059_RS04245	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FO059_RS04245	COG0519	Catalyzes the synthesis of GMP from XMP
FO059_RS04265	COG2197	response regulator
FO059_RS04270	COG3507	Belongs to the glycosyl hydrolase 43 family
FO059_RS04275	COG0515	serine threonine protein kinase
FO059_RS04275	COG2815	serine threonine protein kinase
FO059_RS04280	COG2267	carboxylic ester hydrolase activity
FO059_RS04345	COG1595	DNA-templated transcription, initiation
FO059_RS04360	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FO059_RS04385	COG0587	DNA-directed DNA polymerase activity
FO059_RS04420	COG1668	transmembrane transport
FO059_RS04425	COG4152	abc transporter atp-binding protein
FO059_RS04440	COG0488	(ABC) transporter
FO059_RS04445	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FO059_RS04455	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FO059_RS04470	COG2873	o-acetylhomoserine
FO059_RS04485	COG2814	Major facilitator Superfamily
FO059_RS04490	COG0708	Exodeoxyribonuclease III
FO059_RS04505	COG0517	IMP dehydrogenase activity
FO059_RS04505	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FO059_RS04510	COG0180	Tryptophanyl-tRNA synthetase
FO059_RS04515	COG1295	ribonuclease BN
FO059_RS04520	COG0247	lactate metabolic process
FO059_RS04520	COG0277	FAD linked oxidase domain protein
FO059_RS04560	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FO059_RS04565	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FO059_RS04580	COG2009	succinate dehydrogenase
FO059_RS04595	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FO059_RS04635	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FO059_RS04635	COG1473	amidohydrolase
FO059_RS04655	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FO059_RS04690	COG4770	biotin carboxylase activity
FO059_RS04715	COG0424	maF-like protein
FO059_RS04725	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FO059_RS04730	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FO059_RS04730	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FO059_RS04755	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FO059_RS04780	COG0277	FAD linked oxidase domain protein
FO059_RS04800	COG1316	TRANSCRIPTIONal
FO059_RS04815	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FO059_RS04830	COG0778	Nitroreductase
FO059_RS04830	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
FO059_RS04850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FO059_RS04855	COG2835	tetraacyldisaccharide 4'-kinase activity
FO059_RS04865	COG1482	cell wall glycoprotein biosynthetic process
FO059_RS04885	COG0745	RESPONSE REGULATOR receiver
FO059_RS04890	COG5002	protein histidine kinase activity
FO059_RS04905	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FO059_RS04910	COG0653	protein targeting
FO059_RS04970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FO059_RS04995	COG4691	Plasmid stability protein
FO059_RS05000	COG1487	ribonuclease activity
FO059_RS05015	COG1024	Enoyl-CoA hydratase
FO059_RS05025	COG2070	2-Nitropropane dioxygenase
FO059_RS05050	COG1960	acyl-CoA dehydrogenase activity
FO059_RS05055	COG1960	acyl-CoA dehydrogenase activity
FO059_RS05065	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FO059_RS05070	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FO059_RS05095	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FO059_RS05115	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
FO059_RS05140	COG2193	ferroxidase activity
FO059_RS05155	COG0537	adenosine 5'-monophosphoramidase activity
FO059_RS05160	COG0151	Belongs to the GarS family
FO059_RS05165	COG0436	Aminotransferase
FO059_RS05175	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FO059_RS05180	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FO059_RS05200	COG0386	Belongs to the glutathione peroxidase family
FO059_RS05210	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FO059_RS05215	COG0047	phosphoribosylformylglycinamidine synthase activity
FO059_RS05230	COG1362	aminopeptidase activity
FO059_RS05260	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FO059_RS05275	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FO059_RS05285	COG4044	May play a role in the intracellular transport of hydrophobic ligands
FO059_RS05295	COG2897	thiosulfate sulfurtransferase activity
FO059_RS05315	COG0745	RESPONSE REGULATOR receiver
FO059_RS05320	COG0456	acetyltransferase
FO059_RS05320	COG0454	-acetyltransferase
FO059_RS05340	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FO059_RS05345	COG1960	acyl-CoA dehydrogenase activity
FO059_RS05375	COG0318	PFAM AMP-dependent synthetase and ligase
FO059_RS05380	COG0542	response to heat
FO059_RS05410	COG1126	abc transporter atp-binding protein
FO059_RS05415	COG0765	amino acid transport
FO059_RS05420	COG0765	amino acid transport
FO059_RS05430	COG0477	Major facilitator Superfamily
FO059_RS05445	COG0318	PFAM AMP-dependent synthetase and ligase
FO059_RS05450	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FO059_RS05460	COG1960	acyl-CoA dehydrogenase activity
FO059_RS05465	COG2030	dehydratase
FO059_RS05485	COG1473	amidohydrolase
FO059_RS05490	COG1028	Short-chain dehydrogenase reductase Sdr
FO059_RS05495	COG1028	Short-chain dehydrogenase reductase Sdr
FO059_RS05505	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FO059_RS05545	COG1309	transcriptional regulator
FO059_RS05565	COG0318	PFAM AMP-dependent synthetase and ligase
FO059_RS05580	COG0318	PFAM AMP-dependent synthetase and ligase
FO059_RS05590	COG1028	Short-chain dehydrogenase reductase Sdr
FO059_RS05610	COG1162	GTPase activity
FO059_RS05625	COG1960	acyl-CoA dehydrogenase activity
FO059_RS05660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FO059_RS05680	COG1846	Transcriptional regulator
FO059_RS05685	COG2197	response regulator
FO059_RS05695	COG3631	Ketosteroid isomerase-related protein
FO059_RS05700	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FO059_RS05715	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FO059_RS05725	COG3800	Transcriptional regulator
FO059_RS05725	COG1396	sequence-specific DNA binding
FO059_RS05745	COG1454	alcohol dehydrogenase
FO059_RS05770	COG2755	lipolytic protein G-D-S-L family
FO059_RS05780	COG2197	response regulator
FO059_RS05805	COG0535	radical SAM domain protein
FO059_RS05820	COG0446	pyridine nucleotide-disulphide oxidoreductase
FO059_RS05820	COG1902	pentaerythritol trinitrate reductase activity
FO059_RS05840	COG0446	pyridine nucleotide-disulphide oxidoreductase
FO059_RS05840	COG1902	pentaerythritol trinitrate reductase activity
FO059_RS05885	COG1960	acyl-CoA dehydrogenase activity
FO059_RS05890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FO059_RS05900	COG0183	Belongs to the thiolase family
FO059_RS05905	COG1250	3-hydroxyacyl-CoA dehydrogenase
FO059_RS05905	COG1024	Enoyl-CoA hydratase
FO059_RS05950	COG0657	acetylesterase activity
FO059_RS05965	COG2072	flavoprotein involved in K transport
FO059_RS05975	COG1061	Type III restriction enzyme res subunit
FO059_RS05995	COG0521	Mo-molybdopterin cofactor biosynthetic process
FO059_RS05995	COG0315	cyclic pyranopterin monophosphate synthase activity
FO059_RS06035	COG1278	Cold shock
FO059_RS06045	COG2814	Major facilitator Superfamily
FO059_RS06065	COG2252	PERMEase
FO059_RS06080	COG1960	acyl-CoA dehydrogenase activity
FO059_RS06090	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FO059_RS06105	COG0545	Peptidyl-prolyl cis-trans isomerase
FO059_RS06110	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FO059_RS06110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FO059_RS06130	COG1012	belongs to the aldehyde dehydrogenase family
FO059_RS06135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FO059_RS06140	COG3540	Alkaline phosphatase
FO059_RS06185	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FO059_RS06200	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FO059_RS06200	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FO059_RS06210	COG2272	Belongs to the type-B carboxylesterase lipase family
FO059_RS06230	COG0598	Magnesium transport protein CorA
FO059_RS06250	COG0789	Transcriptional regulator
FO059_RS06270	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FO059_RS06280	COG3409	Peptidoglycan-binding domain 1 protein
FO059_RS06280	COG3757	hydrolase, family 25
FO059_RS06295	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FO059_RS06300	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FO059_RS06305	COG0166	Belongs to the GPI family
FO059_RS06335	COG0739	heme binding
FO059_RS06340	COG0045	succinate-CoA ligase (ADP-forming) activity
FO059_RS06370	COG2409	Drug exporters of the RND superfamily
FO059_RS06390	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FO059_RS06395	COG2860	membrane
FO059_RS06400	COG0745	RESPONSE REGULATOR receiver
FO059_RS06405	COG2205	protein histidine kinase activity
FO059_RS06410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FO059_RS06415	COG0521	Mo-molybdopterin cofactor biosynthetic process
FO059_RS06415	COG0315	cyclic pyranopterin monophosphate synthase activity
FO059_RS06435	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FO059_RS06440	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FO059_RS06450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FO059_RS06485	COG0739	heme binding
FO059_RS06495	COG1028	Short-chain dehydrogenase reductase Sdr
FO059_RS06530	COG1725	Transcriptional regulator
FO059_RS06555	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FO059_RS06560	COG0084	hydrolase, TatD family'
FO059_RS06570	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FO059_RS06575	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FO059_RS06580	COG0488	(ABC) transporter
FO059_RS06585	COG1024	Enoyl-CoA hydratase
FO059_RS06595	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FO059_RS06615	COG1393	Belongs to the ArsC family
FO059_RS06625	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FO059_RS06630	COG0121	glutamine amidotransferase
FO059_RS06635	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
FO059_RS06660	COG2188	Transcriptional regulator
FO059_RS06665	COG1119	ATPase activity
FO059_RS06705	COG0747	negative chemotaxis
FO059_RS06710	COG0747	negative chemotaxis
FO059_RS06720	COG0444	Belongs to the ABC transporter superfamily
FO059_RS06730	COG3119	arylsulfatase activity
FO059_RS06735	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FO059_RS06740	COG1309	transcriptional regulator
FO059_RS06745	COG3119	arylsulfatase activity
FO059_RS06750	COG1472	Belongs to the glycosyl hydrolase 3 family
FO059_RS06765	COG3956	TIGRFAM MazG family protein
FO059_RS06775	COG3328	transposase activity
FO059_RS06785	COG2175	clavaminate synthase activity
FO059_RS06795	COG0148	phosphopyruvate hydratase activity
FO059_RS06825	COG2135	peptidase activity
FO059_RS06835	COG0183	Belongs to the thiolase family
FO059_RS06840	COG2755	lipolytic protein G-D-S-L family
FO059_RS06880	COG1131	(ABC) transporter
FO059_RS06885	COG3559	Exporter of polyketide antibiotics
FO059_RS06895	COG2814	Major facilitator Superfamily
FO059_RS06905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FO059_RS06940	COG0798	PFAM Bile acid sodium symporter
FO059_RS06990	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FO059_RS07010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FO059_RS07020	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FO059_RS07030	COG1331	Highly conserved protein containing a thioredoxin domain
FO059_RS07035	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FO059_RS07050	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FO059_RS07065	COG1072	(Pantothenic acid kinase))
FO059_RS07075	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FO059_RS07090	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FO059_RS07095	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FO059_RS07115	COG1218	3'(2'),5'-bisphosphate nucleotidase
FO059_RS07175	COG1570	exodeoxyribonuclease VII activity
FO059_RS07185	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FO059_RS07195	COG1322	Protein conserved in bacteria
FO059_RS07200	COG0420	3'-5' exonuclease activity
FO059_RS07205	COG0419	ATPase involved in DNA repair
FO059_RS07210	COG0628	permease
FO059_RS07220	COG0012	GTP binding
FO059_RS07240	COG0798	PFAM Bile acid sodium symporter
FO059_RS07245	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FO059_RS07250	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FO059_RS07260	COG2072	flavoprotein involved in K transport
FO059_RS07270	COG0640	Transcriptional regulator
FO059_RS07275	COG0456	acetyltransferase
FO059_RS07285	COG0789	Transcriptional regulator
FO059_RS07290	COG3549	Plasmid maintenance system killer
FO059_RS07350	COG0477	Major facilitator Superfamily
FO059_RS07360	COG0456	acetyltransferase
FO059_RS07385	COG0564	pseudouridine synthase activity
FO059_RS07395	COG2826	transposase and inactivated derivatives, IS30 family
FO059_RS07400	COG2826	transposase and inactivated derivatives, IS30 family
FO059_RS07415	COG1716	ATPase activity
FO059_RS07415	COG1131	(ABC) transporter
FO059_RS07415	COG0842	Transport permease protein
FO059_RS07420	COG2066	Belongs to the glutaminase family
FO059_RS07435	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FO059_RS07445	COG0649	NAD binding
FO059_RS07455	COG1034	ATP synthesis coupled electron transport
FO059_RS07460	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FO059_RS07520	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FO059_RS07520	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FO059_RS07580	COG3842	ATPase activity
FO059_RS07585	COG1217	gtp-binding protein TYPA
FO059_RS07590	COG0747	negative chemotaxis
FO059_RS07595	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FO059_RS07605	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FO059_RS07630	COG0318	PFAM AMP-dependent synthetase and ligase
FO059_RS07635	COG3467	pyridoxamine 5'-phosphate
FO059_RS07655	COG1113	amino acid transport
FO059_RS07665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FO059_RS07670	COG1611	Belongs to the LOG family
FO059_RS07675	COG1611	Belongs to the LOG family
FO059_RS07680	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FO059_RS07685	COG0463	Glycosyl transferase, family 2
FO059_RS07700	COG2226	methyltransferase
FO059_RS07705	COG4122	O-methyltransferase activity
FO059_RS07715	COG5662	AntiSigma factor
FO059_RS07720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FO059_RS07725	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FO059_RS07745	COG2239	Acts as a magnesium transporter
FO059_RS07775	COG0613	PHP domain protein
FO059_RS07810	COG1309	transcriptional regulator
FO059_RS07815	COG0508	dehydrogenase complex catalyzes the overall conversion of
FO059_RS07815	COG0567	Dehydrogenase, E1 component
FO059_RS07820	COG1132	(ABC) transporter
FO059_RS07875	COG1960	acyl-CoA dehydrogenase activity
FO059_RS07895	COG2272	Belongs to the type-B carboxylesterase lipase family
FO059_RS07900	COG3757	hydrolase, family 25
FO059_RS07945	COG0477	Major facilitator Superfamily
FO059_RS07955	COG0508	dehydrogenase complex catalyzes the overall conversion of
FO059_RS07960	COG0022	dehydrogenase e1 component
FO059_RS07985	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FO059_RS08010	COG0018	arginyl-trna synthetase
FO059_RS08015	COG0019	diaminopimelate decarboxylase activity
FO059_RS08020	COG0460	homoserine dehydrogenase
FO059_RS08025	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FO059_RS08030	COG0083	homoserine kinase activity
FO059_RS08035	COG0318	PFAM AMP-dependent synthetase and ligase
FO059_RS08045	COG0254	rRNA binding
FO059_RS08050	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FO059_RS08055	COG2890	protein-(glutamine-N5) methyltransferase activity
FO059_RS08075	COG0356	it plays a direct role in the translocation of protons across the membrane
FO059_RS08080	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FO059_RS08085	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FO059_RS08090	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FO059_RS08095	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FO059_RS08100	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FO059_RS08105	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FO059_RS08125	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FO059_RS08150	COG0647	UMP catabolic process
FO059_RS08180	COG0504	CTP synthase activity
FO059_RS08185	COG0494	nUDIX hydrolase
FO059_RS08200	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FO059_RS08205	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FO059_RS08210	COG1187	pseudouridine synthase activity
FO059_RS08215	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FO059_RS08220	COG1160	GTP binding
FO059_RS08230	COG0488	(ABC) transporter
FO059_RS08240	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FO059_RS08270	COG1716	ATPase activity
FO059_RS08290	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FO059_RS08290	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FO059_RS08300	COG1253	flavin adenine dinucleotide binding
FO059_RS08315	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FO059_RS08335	COG1252	NADH dehydrogenase
FO059_RS08385	COG2175	clavaminate synthase activity
FO059_RS08390	COG3246	L-lysine catabolic process to acetate
FO059_RS08415	COG0318	PFAM AMP-dependent synthetase and ligase
FO059_RS08455	COG1012	belongs to the aldehyde dehydrogenase family
FO059_RS08465	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
FO059_RS08470	COG0693	protein deglycase activity
FO059_RS08505	COG2890	protein-(glutamine-N5) methyltransferase activity
FO059_RS08515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FO059_RS08525	COG0069	glutamate synthase activity
FO059_RS08530	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FO059_RS08545	COG1228	amidohydrolase
FO059_RS08555	COG2239	Acts as a magnesium transporter
FO059_RS08570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FO059_RS08575	COG0300	oxidoreductase activity
FO059_RS08630	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FO059_RS08675	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FO059_RS08685	COG1410	methionine synthase
FO059_RS08685	COG0646	methionine synthase
FO059_RS08695	COG0215	cysteine-tRNA ligase activity
FO059_RS08715	COG0667	Aldo Keto reductase
FO059_RS08730	COG4558	Periplasmic binding protein
FO059_RS08735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO059_RS08740	COG1120	ATPase activity
FO059_RS08780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FO059_RS08840	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FO059_RS08845	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FO059_RS08850	COG1028	Short-chain dehydrogenase reductase Sdr
FO059_RS08855	COG2304	oxidoreductase activity
FO059_RS08865	COG0714	Associated with various cellular activities
FO059_RS08870	COG0791	NLP P60 protein
FO059_RS08870	COG3883	PFAM NLP P60 protein
FO059_RS08880	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FO059_RS08885	COG1309	transcriptional regulator
FO059_RS08890	COG0488	(ABC) transporter
FO059_RS08895	COG1028	Short-chain dehydrogenase reductase Sdr
FO059_RS08900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FO059_RS08910	COG2151	metal-sulfur cluster biosynthetic enzyme
FO059_RS08915	COG0822	iron-sulfur transferase activity
FO059_RS08925	COG0396	ATPase activity
FO059_RS08950	COG1131	(ABC) transporter
FO059_RS08970	COG0109	protoheme IX farnesyltransferase activity
FO059_RS08980	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FO059_RS09000	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FO059_RS09030	COG0149	triose-phosphate isomerase activity
FO059_RS09035	COG0126	phosphoglycerate kinase activity
FO059_RS09040	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FO059_RS09055	COG1660	Displays ATPase and GTPase activities
FO059_RS09075	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FO059_RS09075	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FO059_RS09115	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FO059_RS09130	COG0194	GDP metabolic process
FO059_RS09145	COG0284	orotidine-5'-phosphate decarboxylase activity
FO059_RS09155	COG0505	Belongs to the CarA family
FO059_RS09180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FO059_RS09210	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FO059_RS09225	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FO059_RS09235	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FO059_RS09240	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FO059_RS09255	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FO059_RS09265	COG0028	Belongs to the TPP enzyme family
FO059_RS09270	COG2376	Dihydroxyacetone kinase
FO059_RS09280	COG0318	PFAM AMP-dependent synthetase and ligase
FO059_RS09285	COG1283	sodium-dependent phosphate transmembrane transporter activity
FO059_RS09290	COG0095	Lipoate-protein ligase
FO059_RS09315	COG1501	Belongs to the glycosyl hydrolase 31 family
FO059_RS09340	COG0574	Belongs to the PEP-utilizing enzyme family
FO059_RS09340	COG3848	Pyruvate phosphate dikinase
FO059_RS09360	COG1501	Belongs to the glycosyl hydrolase 31 family
FO059_RS09375	COG2814	Major facilitator Superfamily
FO059_RS09395	COG2226	methyltransferase
FO059_RS09425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FO059_RS09455	COG0653	protein targeting
FO059_RS09470	COG0477	Major facilitator Superfamily
FO059_RS09485	COG2365	Tyrosine phosphatase family
FO059_RS09495	COG1131	(ABC) transporter
FO059_RS09510	COG3328	transposase activity
FO059_RS09525	COG1473	amidohydrolase
FO059_RS09535	COG0154	amidase activity
FO059_RS09560	COG3548	integral membrane protein
FO059_RS09565	COG1252	NADH dehydrogenase
FO059_RS09580	COG4585	Histidine kinase
FO059_RS09585	COG2197	response regulator
FO059_RS09635	COG0318	PFAM AMP-dependent synthetase and ligase
FO059_RS09660	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FO059_RS09665	COG1028	Short-chain dehydrogenase reductase Sdr
FO059_RS09670	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FO059_RS09685	COG1024	Enoyl-CoA hydratase
FO059_RS09690	COG0318	PFAM AMP-dependent synthetase and ligase
FO059_RS09720	COG0124	histidyl-tRNA synthetase
FO059_RS09725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FO059_RS09735	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FO059_RS09740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FO059_RS09745	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FO059_RS09750	COG0747	negative chemotaxis
FO059_RS09755	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FO059_RS09765	COG1862	Preprotein translocase
FO059_RS09770	COG2255	four-way junction helicase activity
FO059_RS09775	COG0632	four-way junction helicase activity
FO059_RS09780	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FO059_RS09790	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
FO059_RS09795	COG1946	Acyl-CoA thioesterase
FO059_RS09800	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
FO059_RS09810	COG0438	transferase activity, transferring glycosyl groups
FO059_RS09815	COG1560	Kdo2-lipid A biosynthetic process
FO059_RS09830	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FO059_RS09835	COG2318	DinB family
FO059_RS09880	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FO059_RS09890	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
FO059_RS09890	COG3608	succinylglutamate desuccinylase aspartoacylase
FO059_RS09940	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FO059_RS09945	COG3253	May function as heme-dependent peroxidase
FO059_RS09950	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
FO059_RS09955	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FO059_RS09965	COG0657	acetylesterase activity
FO059_RS09980	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FO059_RS09985	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FO059_RS09990	COG0531	amino acid
FO059_RS09995	COG0569	domain protein
FO059_RS10025	COG0756	dUTP diphosphatase activity
FO059_RS10045	COG0483	inositol monophosphate 1-phosphatase activity
FO059_RS10060	COG0475	glutathione-regulated potassium exporter activity
FO059_RS10110	COG0123	including yeast histone deacetylase and acetoin utilization protein
FO059_RS10200	COG1129	ABC transporter
FO059_RS10205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FO059_RS10210	COG1643	Atp-dependent helicase
FO059_RS10215	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FO059_RS10235	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FO059_RS10245	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FO059_RS10250	COG1414	Transcriptional regulator
FO059_RS10255	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FO059_RS10265	COG1196	nuclear chromosome segregation
FO059_RS10275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FO059_RS10280	COG1126	abc transporter atp-binding protein
FO059_RS10285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FO059_RS10290	COG0765	amino acid transport
FO059_RS10295	COG0765	amino acid transport
FO059_RS10300	COG2137	regulation of response to DNA damage stimulus
FO059_RS10305	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FO059_RS10320	COG1268	BioY protein
FO059_RS10325	COG1122	ATPase activity
FO059_RS10330	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FO059_RS10335	COG1842	Phage shock protein A
FO059_RS10340	COG1396	sequence-specific DNA binding
FO059_RS10345	COG1058	Belongs to the CinA family
FO059_RS10345	COG1546	Belongs to the CinA family
FO059_RS10355	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FO059_RS10365	COG1674	ftsk spoiiie
FO059_RS10370	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FO059_RS10375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FO059_RS10400	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FO059_RS10410	COG1185	polyribonucleotide nucleotidyltransferase activity
FO059_RS10415	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FO059_RS10425	COG1321	iron dependent repressor
FO059_RS10430	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FO059_RS10440	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FO059_RS10445	COG0534	Mate efflux family protein
FO059_RS10450	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FO059_RS10455	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FO059_RS10470	COG0195	Participates in both transcription termination and antitermination
FO059_RS10490	COG0442	prolyl-tRNA aminoacylation
FO059_RS10495	COG3022	response to hydroperoxide
FO059_RS10500	COG1648	precorrin-2 dehydrogenase activity
FO059_RS10500	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FO059_RS10505	COG0579	oxidoreductase
FO059_RS10535	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FO059_RS10540	COG0768	penicillin binding
FO059_RS10560	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FO059_RS10575	COG5416	Lipopolysaccharide assembly protein A domain
FO059_RS10585	COG0233	cytoplasmic translational termination
FO059_RS10590	COG0528	UMP kinase activity
FO059_RS10595	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FO059_RS10600	COG0052	Belongs to the universal ribosomal protein uS2 family
FO059_RS10625	COG0792	nuclease activity
FO059_RS10635	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FO059_RS10640	COG0681	Belongs to the peptidase S26 family
FO059_RS10645	COG0335	large ribosomal subunit rRNA binding
FO059_RS10650	COG2183	response to ionizing radiation
FO059_RS10655	COG0336	Belongs to the RNA methyltransferase TrmD family
FO059_RS10660	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FO059_RS10670	COG0228	four-way junction DNA binding
FO059_RS10710	COG1254	Belongs to the acylphosphatase family
FO059_RS10725	COG1028	Short-chain dehydrogenase reductase Sdr
FO059_RS10735	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FO059_RS10745	COG1733	regulation of RNA biosynthetic process
FO059_RS10765	COG2361	Protein of unknown function DUF86
FO059_RS10780	COG0571	ribonuclease III activity
FO059_RS10785	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FO059_RS10805	COG0742	ribosomal rna small subunit methyltransferase
FO059_RS10810	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FO059_RS10815	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FO059_RS10820	COG1461	Dihydroxyacetone kinase
FO059_RS10825	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FO059_RS10830	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FO059_RS10835	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FO059_RS10850	COG1181	Belongs to the D-alanine--D-alanine ligase family
FO059_RS10855	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FO059_RS10860	COG1920	GTP binding
FO059_RS10865	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FO059_RS10880	COG0066	3-isopropylmalate dehydratase activity
FO059_RS10885	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FO059_RS10890	COG1414	Transcriptional regulator
FO059_RS10905	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FO059_RS10910	COG0318	PFAM AMP-dependent synthetase and ligase
FO059_RS10915	COG0179	Fumarylacetoacetate (FAA) hydrolase
FO059_RS10920	COG0473	3-isopropylmalate dehydrogenase activity
FO059_RS10935	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FO059_RS10940	COG0440	acetolactate synthase activity
FO059_RS10955	COG0129	dihydroxy-acid dehydratase activity
FO059_RS10960	COG2259	Doxx family
FO059_RS10975	COG0205	6-phosphofructokinase activity
FO059_RS10985	COG2197	response regulator
FO059_RS10990	COG4585	Histidine kinase
FO059_RS11005	COG0154	amidase activity
FO059_RS11010	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FO059_RS11020	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FO059_RS11040	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FO059_RS11050	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FO059_RS11070	COG0110	maltose O-acetyltransferase activity
FO059_RS11100	COG1119	ATPase activity
FO059_RS11105	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FO059_RS11125	COG0183	Belongs to the thiolase family
FO059_RS11145	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
FO059_RS11160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FO059_RS11160	COG1017	nitric oxide dioxygenase activity
FO059_RS11165	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FO059_RS11180	COG1201	RNA secondary structure unwinding
FO059_RS11205	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FO059_RS11210	COG2094	Belongs to the DNA glycosylase MPG family
FO059_RS11220	COG0165	Argininosuccinate lyase
FO059_RS11235	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FO059_RS11240	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FO059_RS11245	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FO059_RS11250	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FO059_RS11255	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FO059_RS11260	COG0072	phenylalanine-tRNA ligase activity
FO059_RS11260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FO059_RS11265	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FO059_RS11275	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FO059_RS11280	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FO059_RS11295	COG0577	efflux transmembrane transporter activity
FO059_RS11295	COG1136	(ABC) transporter
FO059_RS11310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FO059_RS11345	COG0237	dephospho-CoA kinase activity
FO059_RS11345	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FO059_RS11355	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FO059_RS11365	COG0765	amino acid transport
FO059_RS11370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FO059_RS11390	COG0733	neurotransmitter:sodium symporter activity
FO059_RS11420	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FO059_RS11430	COG2226	methyltransferase
FO059_RS11435	COG1053	succinate dehydrogenase
FO059_RS11445	COG1946	Acyl-CoA thioesterase
FO059_RS11460	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FO059_RS11475	COG0134	indole-3-glycerol-phosphate synthase activity
FO059_RS11485	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FO059_RS11500	COG1595	DNA-templated transcription, initiation
FO059_RS11505	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FO059_RS11510	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FO059_RS11520	COG0107	imidazoleglycerol-phosphate synthase activity
FO059_RS11525	COG0483	inositol monophosphate 1-phosphatase activity
FO059_RS11530	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FO059_RS11540	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FO059_RS11545	COG0131	Imidazoleglycerol-phosphate dehydratase
FO059_RS11555	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FO059_RS11560	COG0157	Belongs to the NadC ModD family
FO059_RS11615	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FO059_RS11635	COG1115	amino acid carrier protein
FO059_RS11640	COG1739	Uncharacterized protein family UPF0029
FO059_RS11650	COG0156	8-amino-7-oxononanoate synthase activity
FO059_RS11655	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FO059_RS11680	COG0477	Major facilitator Superfamily
FO059_RS11710	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FO059_RS11725	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FO059_RS11755	COG1496	oxidoreductase activity
FO059_RS11760	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FO059_RS11770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FO059_RS11775	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FO059_RS11785	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FO059_RS11805	COG0768	penicillin binding
FO059_RS11815	COG0275	rRNA processing
FO059_RS11820	COG2001	Belongs to the MraZ family
FO059_RS11855	COG0142	geranyltranstransferase activity
FO059_RS11885	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FO059_RS11910	COG0003	Pfam Anion-transporting ATPase
FO059_RS11930	COG0438	transferase activity, transferring glycosyl groups
FO059_RS11960	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FO059_RS11970	COG1845	cytochrome c oxidase, subunit III
FO059_RS11990	COG1250	3-hydroxyacyl-CoA dehydrogenase
FO059_RS12000	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FO059_RS12010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FO059_RS12040	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FO059_RS12045	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FO059_RS12050	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FO059_RS12070	COG0321	lipoyl(octanoyl) transferase activity
FO059_RS12075	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FO059_RS12090	COG0174	glutamine synthetase
FO059_RS12100	COG1174	glycine betaine transport
FO059_RS12110	COG1174	glycine betaine transport
FO059_RS12125	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FO059_RS12130	COG0174	glutamine synthetase
FO059_RS12135	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FO059_RS12225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FO059_RS12255	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FO059_RS12260	COG2814	Major facilitator Superfamily
FO059_RS12275	COG4974	Belongs to the 'phage' integrase family
FO059_RS12350	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
FO059_RS12555	COG2826	transposase and inactivated derivatives, IS30 family
FO059_RS12560	COG1002	Type II restriction enzyme, methylase subunits
FO059_RS12575	COG0358	DNA primase activity
FO059_RS12580	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FO059_RS12595	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FO059_RS12600	COG1687	branched-chain amino acid
FO059_RS12620	COG0423	glycine-tRNA ligase activity
FO059_RS12640	COG2066	Belongs to the glutaminase family
FO059_RS12650	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FO059_RS12655	COG1381	Involved in DNA repair and RecF pathway recombination
FO059_RS12680	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FO059_RS12695	COG0484	heat shock protein binding
FO059_RS12700	COG1420	regulation of RNA biosynthetic process
FO059_RS12715	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FO059_RS12760	COG3387	PFAM Glycoside hydrolase 15-related
FO059_RS12765	COG2070	2-Nitropropane dioxygenase
FO059_RS12800	COG2755	lipolytic protein G-D-S-L family
FO059_RS12805	COG0406	alpha-ribazole phosphatase activity
FO059_RS12815	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FO059_RS12825	COG0542	response to heat
FO059_RS12830	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FO059_RS12835	COG3268	Saccharopine dehydrogenase
FO059_RS12840	COG0514	ATP-dependent DNA helicase (RecQ)
FO059_RS12845	COG0456	acetyltransferase
FO059_RS12850	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FO059_RS12855	COG1917	Cupin 2, conserved barrel domain protein
FO059_RS12875	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FO059_RS12890	COG1530	ribonuclease E activity
FO059_RS12890	COG1530	ribonuclease E activity
FO059_RS12905	COG0285	dihydrofolate synthase activity
FO059_RS12910	COG0525	valine-tRNA ligase activity
FO059_RS12935	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FO059_RS12955	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FO059_RS12960	COG1414	Transcriptional regulator
FO059_RS12965	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FO059_RS12970	COG0740	serine-type endopeptidase activity
FO059_RS12975	COG0740	serine-type endopeptidase activity
FO059_RS12980	COG0544	peptidyl-prolyl cis-trans isomerase activity
FO059_RS13035	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FO059_RS13040	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FO059_RS13080	COG2902	Dehydrogenase
FO059_RS13125	COG5285	phytanoyl-CoA dioxygenase
FO059_RS13135	COG1902	pentaerythritol trinitrate reductase activity
FO059_RS13135	COG0446	pyridine nucleotide-disulphide oxidoreductase
FO059_RS13155	COG4221	oxidoreductase activity
FO059_RS13160	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FO059_RS13180	COG1376	ErfK ybiS ycfS ynhG family protein
FO059_RS13215	COG1136	(ABC) transporter
FO059_RS13230	COG2197	response regulator
FO059_RS13250	COG2030	dehydratase
FO059_RS13255	COG0477	Major facilitator Superfamily
FO059_RS13325	COG4974	Belongs to the 'phage' integrase family
FO059_RS13350	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FO059_RS13355	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FO059_RS13365	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FO059_RS13385	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FO059_RS13390	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FO059_RS13395	COG1335	isochorismatase
FO059_RS13415	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FO059_RS13440	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FO059_RS13460	COG2267	carboxylic ester hydrolase activity
FO059_RS13475	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FO059_RS13480	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FO059_RS13485	COG0569	domain protein
FO059_RS13490	COG0583	DNA-binding transcription factor activity
FO059_RS13510	COG1595	DNA-templated transcription, initiation
FO059_RS13550	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FO059_RS13555	COG2177	Part of the ABC transporter FtsEX involved in
FO059_RS13560	COG2884	Cell division ATP-binding protein ftsE
FO059_RS13565	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FO059_RS13570	COG0483	inositol monophosphate 1-phosphatase activity
FO059_RS13580	COG5002	protein histidine kinase activity
FO059_RS13580	COG3850	Histidine kinase
FO059_RS13600	COG1960	acyl-CoA dehydrogenase activity
FO059_RS13605	COG1960	acyl-CoA dehydrogenase activity
FO059_RS13610	COG0488	(ABC) transporter
FO059_RS13615	COG0318	PFAM AMP-dependent synthetase and ligase
FO059_RS13635	COG1615	UPF0182 protein
FO059_RS13645	COG3480	Lon protease (S16) C-terminal proteolytic domain
FO059_RS13665	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FO059_RS13685	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FO059_RS13690	COG0210	DNA helicase
FO059_RS13700	COG0596	Alpha beta hydrolase
FO059_RS13715	COG2186	Transcriptional regulator
FO059_RS13755	COG0513	Belongs to the DEAD box helicase family
FO059_RS13770	COG0406	alpha-ribazole phosphatase activity
FO059_RS13790	COG1597	lipid kinase activity
FO059_RS13820	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FO059_RS13825	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FO059_RS13830	COG1162	GTPase activity
FO059_RS13835	COG2124	cytochrome p450
FO059_RS13840	COG0183	Belongs to the thiolase family
FO059_RS13850	COG1028	Short-chain dehydrogenase reductase Sdr
FO059_RS13855	COG1024	Enoyl-CoA hydratase
FO059_RS13880	COG0183	Belongs to the thiolase family
FO059_RS13885	COG1309	transcriptional regulator
FO059_RS13890	COG1028	Short-chain dehydrogenase reductase Sdr
FO059_RS13895	COG1960	acyl-CoA dehydrogenase activity
FO059_RS13900	COG0318	PFAM AMP-dependent synthetase and ligase
FO059_RS13905	COG1960	acyl-CoA dehydrogenase activity
FO059_RS13910	COG1960	acyl-CoA dehydrogenase activity
FO059_RS13915	COG1960	acyl-CoA dehydrogenase activity
FO059_RS13920	COG0596	Alpha beta hydrolase
FO059_RS13935	COG4829	muconolactone delta-isomerase
FO059_RS13940	COG4948	Mandelate Racemase Muconate Lactonizing
FO059_RS13945	COG3485	protocatechuate 3,4-dioxygenase
FO059_RS13950	COG1414	Transcriptional regulator
FO059_RS13955	COG0583	DNA-binding transcription factor activity
FO059_RS13985	COG2871	sodium ion transport
FO059_RS13990	COG0583	DNA-binding transcription factor activity
FO059_RS13995	COG0657	acetylesterase activity
FO059_RS14000	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FO059_RS14005	COG0346	lactoylglutathione lyase activity
FO059_RS14010	COG1960	acyl-CoA dehydrogenase activity
FO059_RS14025	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FO059_RS14035	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
FO059_RS14045	COG1053	succinate dehydrogenase
FO059_RS14050	COG2030	dehydratase
FO059_RS14065	COG0730	response to heat
FO059_RS14095	COG0577	efflux transmembrane transporter activity
FO059_RS14095	COG1136	(ABC) transporter
FO059_RS14130	COG2030	dehydratase
FO059_RS14135	COG1960	acyl-CoA dehydrogenase activity
FO059_RS14140	COG1960	acyl-CoA dehydrogenase activity
FO059_RS14145	COG1960	acyl-CoA dehydrogenase activity
FO059_RS14150	COG1309	transcriptional regulator
FO059_RS14155	COG3387	PFAM Glycoside hydrolase 15-related
FO059_RS14165	COG1121	(ABC) transporter
FO059_RS14170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FO059_RS14185	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FO059_RS14210	COG0113	porphobilinogen synthase activity
FO059_RS14220	COG0181	hydroxymethylbilane synthase activity
FO059_RS14225	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FO059_RS14290	COG0745	RESPONSE REGULATOR receiver
FO059_RS14300	COG0588	phosphoglycerate mutase activity
FO059_RS14325	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FO059_RS14340	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FO059_RS14355	COG0789	Transcriptional regulator
FO059_RS14375	COG2733	membrane
FO059_RS14410	COG2224	Isocitrate lyase
FO059_RS14420	COG1028	Short-chain dehydrogenase reductase Sdr
FO059_RS14510	COG2072	flavoprotein involved in K transport
FO059_RS14515	COG1028	Short-chain dehydrogenase reductase Sdr
FO059_RS14520	COG1505	serine-type exopeptidase activity
FO059_RS14540	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FO059_RS14540	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FO059_RS14575	COG5343	regulation of RNA biosynthetic process
FO059_RS14580	COG1595	DNA-templated transcription, initiation
FO059_RS14595	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FO059_RS14600	COG2197	response regulator
FO059_RS14610	COG1366	Belongs to the anti-sigma-factor antagonist family
FO059_RS14620	COG2409	Drug exporters of the RND superfamily
FO059_RS14635	COG0415	Belongs to the DNA photolyase family
FO059_RS14640	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FO059_RS14640	COG5479	isomerase activity
FO059_RS14645	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FO059_RS14675	COG0647	UMP catabolic process
FO059_RS14705	COG0604	alcohol dehydrogenase
FO059_RS14725	COG0688	phosphatidylethanolamine metabolic process
FO059_RS14785	COG1674	ftsk spoiiie
FO059_RS14795	COG1404	Belongs to the peptidase S8 family
FO059_RS14825	COG2111	Na H antiporter
FO059_RS14825	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FO059_RS14830	COG1006	Multisubunit Na H antiporter MnhC subunit
FO059_RS14835	COG0651	ATP synthesis coupled electron transport
FO059_RS14895	COG0277	FAD linked oxidase domain protein
FO059_RS14925	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FO059_RS14930	COG0351	phosphomethylpyrimidine kinase
FO059_RS14955	COG2022	thiamine diphosphate biosynthetic process
FO059_RS14965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FO059_RS14975	COG2267	carboxylic ester hydrolase activity
FO059_RS14990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FO059_RS14995	COG0515	serine threonine protein kinase
FO059_RS15005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FO059_RS15015	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FO059_RS15025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FO059_RS15030	COG1028	Short-chain dehydrogenase reductase Sdr
FO059_RS15035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FO059_RS15055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO059_RS15060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FO059_RS15085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FO059_RS15090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FO059_RS15105	COG3433	isochorismatase activity
FO059_RS15105	COG1535	isochorismatase
FO059_RS15110	COG1169	isochorismate synthase
FO059_RS15115	COG1028	Short-chain dehydrogenase reductase Sdr
FO059_RS15120	COG2382	esterase
FO059_RS15125	COG1120	ATPase activity
FO059_RS15130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO059_RS15135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO059_RS15145	COG1021	2,3-dihydroxybenzoate-AMP ligase
FO059_RS15150	COG1535	isochorismatase
FO059_RS15150	COG3433	isochorismatase activity
FO059_RS15155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FO059_RS15160	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FO059_RS15170	COG1994	Peptidase M50
FO059_RS15175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FO059_RS15185	COG0791	NLP P60 protein
FO059_RS15220	COG2124	cytochrome p450
FO059_RS15260	COG0318	PFAM AMP-dependent synthetase and ligase
FO059_RS15270	COG1309	transcriptional regulator
FO059_RS15275	COG2072	flavoprotein involved in K transport
FO059_RS15300	COG1492	cobalamin metabolic process
FO059_RS15315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO059_RS15320	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO059_RS15325	COG1120	ATPase activity
FO059_RS15350	COG0586	Pfam SNARE associated Golgi protein
FO059_RS15405	COG0542	response to heat
FO059_RS15415	COG0318	PFAM AMP-dependent synthetase and ligase
FO059_RS15435	COG4585	Histidine kinase
FO059_RS15450	COG0789	Transcriptional regulator
FO059_RS15455	COG0484	heat shock protein binding
FO059_RS15460	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FO059_RS15465	COG0443	Heat shock 70 kDa protein
FO059_RS15480	COG2181	nitrate reductase activity
FO059_RS15480	COG0247	lactate metabolic process
FO059_RS15485	COG2197	response regulator
FO059_RS15500	COG1131	(ABC) transporter
FO059_RS15515	COG0586	Pfam SNARE associated Golgi protein
FO059_RS15550	COG3408	Glycogen debranching enzyme
FO059_RS15550	COG3119	arylsulfatase activity
FO059_RS15555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FO059_RS15560	COG0656	L-ascorbic acid biosynthetic process
FO059_RS15575	COG4115	mRNA cleavage
FO059_RS15580	COG2161	toxin-antitoxin pair type II binding
FO059_RS15595	COG0435	Glutathione S-transferase
FO059_RS15600	COG0500	methyltransferase
FO059_RS15605	COG1960	acyl-CoA dehydrogenase activity
FO059_RS15620	COG0702	epimerase
FO059_RS15645	COG0183	Belongs to the thiolase family
FO059_RS15650	COG1028	Short-chain dehydrogenase reductase Sdr
FO059_RS15660	COG1309	transcriptional regulator
FO059_RS15665	COG1472	Belongs to the glycosyl hydrolase 3 family
FO059_RS15670	COG0589	response to stress
FO059_RS15685	COG4981	capsule polysaccharide biosynthetic process
FO059_RS15725	COG0500	methyltransferase
FO059_RS15745	COG1024	Enoyl-CoA hydratase
FO059_RS15750	COG1741	Belongs to the pirin family
FO059_RS15755	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
FO059_RS15760	COG0596	Alpha beta hydrolase
FO059_RS15780	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FO059_RS15790	COG2409	Drug exporters of the RND superfamily
FO059_RS15805	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FO059_RS15815	COG3012	SEC-C Motif Domain Protein
FO059_RS15820	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FO059_RS15840	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
FO059_RS15855	COG2353	YceI-like domain
FO059_RS15865	COG3104	oligopeptide transport
FO059_RS15870	COG1902	pentaerythritol trinitrate reductase activity
FO059_RS15880	COG1846	Transcriptional regulator
FO059_RS15885	COG0596	Alpha beta hydrolase
FO059_RS15890	COG2855	membrane
FO059_RS15910	COG0439	Biotin carboxylase
FO059_RS15925	COG3590	peptidase
FO059_RS15930	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FO059_RS15960	COG1376	ErfK ybiS ycfS ynhG family protein
FO059_RS15965	COG0657	acetylesterase activity
FO059_RS15970	COG0277	FAD linked oxidase domain protein
FO059_RS15975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FO059_RS15980	COG0129	dihydroxy-acid dehydratase activity
FO059_RS15990	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
FO059_RS16015	COG0477	Major facilitator Superfamily
FO059_RS16020	COG3265	gluconokinase activity
FO059_RS16045	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FO059_RS16045	COG5479	isomerase activity
FO059_RS16055	COG1960	acyl-CoA dehydrogenase activity
FO059_RS16060	COG0318	PFAM AMP-dependent synthetase and ligase
FO059_RS16070	COG1024	Enoyl-CoA hydratase
FO059_RS16075	COG0564	pseudouridine synthase activity
FO059_RS16125	COG1518	maintenance of DNA repeat elements
FO059_RS16150	COG2258	MOSC domain
FO059_RS16170	COG0628	permease
FO059_RS16190	COG2015	COG2015, Alkyl sulfatase and related hydrolases
FO059_RS16245	COG1960	acyl-CoA dehydrogenase activity
FO059_RS16260	COG2017	converts alpha-aldose to the beta-anomer
FO059_RS16265	COG0667	Aldo Keto reductase
FO059_RS16280	COG0477	Major facilitator Superfamily
FO059_RS16325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FO059_RS16330	COG0748	coenzyme F420 binding
FO059_RS16335	COG1960	acyl-CoA dehydrogenase activity
FO059_RS16340	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FO059_RS16355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FO059_RS16385	COG0346	lactoylglutathione lyase activity
FO059_RS16395	COG0300	oxidoreductase activity
FO059_RS16400	COG0656	L-ascorbic acid biosynthetic process
FO059_RS16405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FO059_RS16410	COG1584	GPR1 FUN34 yaaH family protein
FO059_RS16415	COG1388	LysM domain
FO059_RS16420	COG3835	regulator
FO059_RS16425	COG0318	PFAM AMP-dependent synthetase and ligase
FO059_RS16440	COG4608	Belongs to the ABC transporter superfamily
FO059_RS16455	COG0601	transmembrane transport
FO059_RS16475	COG0318	PFAM AMP-dependent synthetase and ligase
FO059_RS16490	COG0326	Molecular chaperone. Has ATPase activity
FO059_RS16540	COG0438	transferase activity, transferring glycosyl groups
FO059_RS16545	COG2226	methyltransferase
FO059_RS16580	COG2124	cytochrome p450
FO059_RS16600	COG2124	cytochrome p450
FO059_RS16625	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FO059_RS16650	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FO059_RS16715	COG1131	(ABC) transporter
FO059_RS16725	COG0697	spore germination
FO059_RS16730	COG0726	polysaccharide deacetylase
FO059_RS16740	COG4585	Histidine kinase
FO059_RS16745	COG2197	response regulator
FO059_RS16750	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FO059_RS16765	COG0477	Major facilitator Superfamily
FO059_RS16775	COG1139	Iron-sulfur cluster binding protein
FO059_RS16780	COG1556	Lactate utilization protein
FO059_RS16845	COG0024	Methionine aminopeptidase
FO059_RS16855	COG3304	Inner membrane component domain
FO059_RS16860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FO059_RS16870	COG1252	NADH dehydrogenase
FO059_RS16885	COG0477	Major facilitator Superfamily
FO059_RS16890	COG0477	Major facilitator Superfamily
FO059_RS16925	COG0842	Transport permease protein
FO059_RS17025	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FO059_RS17055	COG2826	transposase and inactivated derivatives, IS30 family
FO059_RS17060	COG2130	NADP-dependent
FO059_RS17080	COG2217	Heavy metal translocating P-type atpase
FO059_RS17090	COG1024	Enoyl-CoA hydratase
FO059_RS17090	COG1250	3-hydroxyacyl-CoA dehydrogenase
FO059_RS17100	COG0300	oxidoreductase activity
FO059_RS17110	COG1028	Short-chain dehydrogenase reductase Sdr
FO059_RS17115	COG1960	acyl-CoA dehydrogenase activity
FO059_RS17135	COG1011	Hydrolase
FO059_RS17180	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FO059_RS17215	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FO059_RS17220	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FO059_RS17225	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FO059_RS17230	COG1802	Transcriptional regulator
FO059_RS17250	COG2837	iron assimilation
FO059_RS17255	COG2822	iron ion transport
FO059_RS17265	COG0671	phosphoesterase, PA-phosphatase related
FO059_RS17270	COG0768	penicillin binding
FO059_RS17280	COG0583	DNA-binding transcription factor activity
FO059_RS17295	COG1028	Short-chain dehydrogenase reductase Sdr
FO059_RS17305	COG0778	Nitroreductase
FO059_RS17325	COG1053	succinate dehydrogenase
FO059_RS17400	COG1309	transcriptional regulator
FO059_RS17405	COG0667	Aldo Keto reductase
FO059_RS17430	COG1028	Short-chain dehydrogenase reductase Sdr
FO059_RS17435	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FO059_RS17445	COG1960	acyl-CoA dehydrogenase activity
FO059_RS17455	COG1024	Enoyl-CoA hydratase
FO059_RS17485	COG0183	Belongs to the thiolase family
FO059_RS17490	COG1960	acyl-CoA dehydrogenase activity
FO059_RS17495	COG0318	PFAM AMP-dependent synthetase and ligase
FO059_RS17505	COG1960	acyl-CoA dehydrogenase activity
FO059_RS17515	COG0318	PFAM AMP-dependent synthetase and ligase
FO059_RS17520	COG2030	dehydratase
FO059_RS17545	COG1028	Short-chain dehydrogenase reductase Sdr
FO059_RS17570	COG1028	Short-chain dehydrogenase reductase Sdr
FO059_RS17580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FO059_RS17590	COG1028	Short-chain dehydrogenase reductase Sdr
FO059_RS17620	COG0359	binds to the 23S rRNA
FO059_RS17625	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FO059_RS17665	COG0860	N-Acetylmuramoyl-L-alanine amidase
FO059_RS17670	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FO059_RS17680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FO059_RS17690	COG1695	Transcriptional regulator
FO059_RS17695	COG1260	myo-inositol-1-phosphate synthase
FO059_RS17745	COG3842	ATPase activity
FO059_RS17775	COG1846	Transcriptional regulator
FO059_RS17780	COG2814	Major facilitator Superfamily
FO059_RS17785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FO059_RS17790	COG4221	oxidoreductase activity
FO059_RS17810	COG3631	Ketosteroid isomerase-related protein
FO059_RS17820	COG0495	leucyl-tRNA aminoacylation
FO059_RS17840	COG1678	Uncharacterized ACR, COG1678
FO059_RS17855	COG0617	tRNA 3'-terminal CCA addition
FO059_RS17895	COG0860	N-Acetylmuramoyl-L-alanine amidase
FO059_RS17895	COG3409	Peptidoglycan-binding domain 1 protein
FO059_RS17910	COG1192	Involved in chromosome partitioning
FO059_RS17915	COG0357	Ribosomal RNA small subunit methyltransferase G
FO059_RS17925	COG0706	membrane insertase activity
FO059_RS17930	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FO059_RS17935	COG0594	ribonuclease P activity
FO059_RS18085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FO059_RS18090	COG2030	dehydratase
FO059_RS18100	COG2175	clavaminate synthase activity
FO059_RS18150	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FO059_RS18205	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
FO059_RS18220	COG1396	sequence-specific DNA binding