locus-tag	class	description
HG536_0A00120	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HG536_0A00140	COG2814	Major facilitator Superfamily
HG536_0A00150	COG2017	converts alpha-aldose to the beta-anomer
HG536_0A00430	COG5265	(ABC) transporter
HG536_0A00510	COG0156	8-amino-7-oxononanoate synthase activity
HG536_0A00560	COG0154	amidase activity
HG536_0A00600	COG0302	gtp cyclohydrolase
HG536_0A00640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG536_0A00640	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG536_0A00770	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HG536_0A00800	COG1902	pentaerythritol trinitrate reductase activity
HG536_0A00840	COG0148	phosphopyruvate hydratase activity
HG536_0A00920	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG536_0A01040	COG0045	succinate-CoA ligase (ADP-forming) activity
HG536_0A01070	COG0205	6-phosphofructokinase activity
HG536_0A01160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HG536_0A01160	COG1017	nitric oxide dioxygenase activity
HG536_0A01330	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HG536_0A01400	COG0513	Belongs to the DEAD box helicase family
HG536_0A01570	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HG536_0A01620	COG0489	protein tyrosine kinase activity
HG536_0A01800	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HG536_0A01890	COG3511	phospholipase C
HG536_0A01980	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HG536_0A02300	COG0473	3-isopropylmalate dehydrogenase activity
HG536_0A02310	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HG536_0A02310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HG536_0A02330	COG2815	serine threonine protein kinase
HG536_0A02330	COG0515	serine threonine protein kinase
HG536_0A02370	COG1965	Belongs to the frataxin family
HG536_0A02450	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG536_0A02450	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG536_0A02460	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HG536_0A02490	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HG536_0A02510	COG1028	Short-chain dehydrogenase reductase Sdr
HG536_0A02530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HG536_0A02590	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HG536_0A02670	COG1012	belongs to the aldehyde dehydrogenase family
HG536_0A02690	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HG536_0A02710	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HG536_0A02770	COG4284	Utp--glucose-1-phosphate uridylyltransferase
HG536_0A02790	COG0484	heat shock protein binding
HG536_0A02810	COG0515	serine threonine protein kinase
HG536_0A02840	COG0003	Pfam Anion-transporting ATPase
HG536_0A02860	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HG536_0A03070	COG0412	Dienelactone hydrolase
HG536_0A03120	COG0513	Belongs to the DEAD box helicase family
HG536_0A03190	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HG536_0A03200	COG3961	Belongs to the TPP enzyme family
HG536_0A03210	COG0515	serine threonine protein kinase
HG536_0A03210	COG2815	serine threonine protein kinase
HG536_0A03220	COG0039	L-malate dehydrogenase activity
HG536_0A03230	COG1160	GTP binding
HG536_0A03370	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HG536_0A03410	COG1643	Atp-dependent helicase
HG536_0A03430	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG536_0A03490	COG0138	bifunctional purine biosynthesis protein purh
HG536_0A03510	COG1448	Aminotransferase
HG536_0A03670	COG0285	dihydrofolate synthase activity
HG536_0A03700	COG1012	belongs to the aldehyde dehydrogenase family
HG536_0A03720	COG0028	Belongs to the TPP enzyme family
HG536_0A03760	COG0033	Phosphoglucomutase
HG536_0A03830	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HG536_0A03880	COG0515	serine threonine protein kinase
HG536_0A03890	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HG536_0A03900	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HG536_0A03900	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HG536_0A03940	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HG536_0A03960	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HG536_0A03970	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HG536_0A04030	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG536_0A04040	COG0477	Major facilitator Superfamily
HG536_0A04060	COG1448	Aminotransferase
HG536_0A04080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HG536_0A04090	COG1362	aminopeptidase activity
HG536_0A04100	COG0515	serine threonine protein kinase
HG536_0A04100	COG2815	serine threonine protein kinase
HG536_0A04400	COG0529	Catalyzes the synthesis of activated sulfate
HG536_0A04500	COG1028	Short-chain dehydrogenase reductase Sdr
HG536_0A04560	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HG536_0A04580	COG0281	malic enzyme
HG536_0A04680	COG2116	formate transmembrane transporter activity
HG536_0A04720	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HG536_0A04825	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
HG536_0A04850	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HG536_0A04870	COG2814	Major facilitator Superfamily
HG536_0A04900	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HG536_0A04910	COG0473	3-isopropylmalate dehydrogenase activity
HG536_0A04920	COG1408	metallophosphoesterase
HG536_0A05040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG536_0A05150	COG0085	RNA polymerase activity
HG536_0A05180	COG1132	(ABC) transporter
HG536_0A05250	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HG536_0A05260	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HG536_0A05340	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HG536_0A05360	COG1394	ATPase activity, coupled to movement of substances
HG536_0A05380	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HG536_0A05550	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HG536_0A05660	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HG536_0A05740	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HG536_0A05760	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HG536_0A05790	COG0386	Belongs to the glutathione peroxidase family
HG536_0A05810	COG2814	Major facilitator Superfamily
HG536_0A05900	COG0450	alkyl hydroperoxide reductase
HG536_0A05930	COG0194	GDP metabolic process
HG536_0A05940	COG0025	NhaP-type Na H and K H
HG536_0A06130	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HG536_0A06140	COG0515	serine threonine protein kinase
HG536_0A06140	COG2815	serine threonine protein kinase
HG536_0A06150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HG536_0A06200	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HG536_0A06290	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HG536_0A06320	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HG536_0A06410	COG0542	response to heat
HG536_0A06550	COG0180	Tryptophanyl-tRNA synthetase
HG536_0A06580	COG2217	Heavy metal translocating P-type atpase
HG536_0A06670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HG536_0A06700	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG536_0A06820	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HG536_0A06830	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HG536_0A06840	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HG536_0A06890	COG0443	Heat shock 70 kDa protein
HG536_0A07060	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HG536_0A07070	COG0123	including yeast histone deacetylase and acetoin utilization protein
HG536_0A07100	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HG536_0A07110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HG536_0A07120	COG0131	Imidazoleglycerol-phosphate dehydratase
HG536_0A07140	COG0513	Belongs to the DEAD box helicase family
HG536_0A07260	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HG536_0A07480	COG0822	iron-sulfur transferase activity
HG536_0A07530	COG2815	serine threonine protein kinase
HG536_0A07530	COG0515	serine threonine protein kinase
HG536_0A07540	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HG536_0A07550	COG2815	serine threonine protein kinase
HG536_0A07550	COG0515	serine threonine protein kinase
HG536_0A07620	COG3842	ATPase activity
HG536_0A07690	COG0515	serine threonine protein kinase
HG536_0A07690	COG2815	serine threonine protein kinase
HG536_0A07700	COG0285	dihydrofolate synthase activity
HG536_0A07720	COG0585	pseudouridine synthase activity
HG536_0A07840	COG0495	leucyl-tRNA aminoacylation
HG536_0A07850	COG1028	Short-chain dehydrogenase reductase Sdr
HG536_0A07890	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HG536_0A07920	COG2897	thiosulfate sulfurtransferase activity
HG536_0A07950	COG0417	DNA replication proofreading
HG536_0A07990	COG0484	heat shock protein binding
HG536_0A08090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG536_0A08110	COG0109	protoheme IX farnesyltransferase activity
HG536_0A08170	COG0515	serine threonine protein kinase
HG536_0A08300	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HG536_0A08310	COG0515	serine threonine protein kinase
HG536_0A08360	COG0326	Molecular chaperone. Has ATPase activity
HG536_0A08440	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HG536_0A08460	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HG536_0A08460	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HG536_0A08470	COG0514	ATP-dependent DNA helicase (RecQ)
HG536_0A08500	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HG536_0A08590	COG0633	Ferredoxin
HG536_0A08770	COG1643	Atp-dependent helicase
HG536_0A08780	COG0572	uridine kinase
HG536_0A08830	COG4770	biotin carboxylase activity
HG536_0A09070	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HG536_0A09090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HG536_0A09100	COG0523	cobalamin synthesis protein
HG536_0A09130	COG2319	Wd-40 repeat
HG536_0A09130	COG4249	Peptidase C14 caspase catalytic subunit p20
HG536_0A09140	COG2815	serine threonine protein kinase
HG536_0A09140	COG0515	serine threonine protein kinase
HG536_0A09170	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HG536_0A09170	COG0512	Glutamine amidotransferase of anthranilate synthase
HG536_0A09260	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HG536_0A09280	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HG536_0A09330	COG3118	belongs to the thioredoxin family
HG536_0A09350	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HG536_0A09450	COG0515	serine threonine protein kinase
HG536_0A09460	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HG536_0A09500	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HG536_0A09580	COG0626	cystathionine gamma-synthase activity
HG536_0A09630	COG2814	Major facilitator Superfamily
HG536_0A09660	COG2175	clavaminate synthase activity
HG536_0B00120	COG2249	NAD(P)H dehydrogenase (quinone) activity
HG536_0B00130	COG0667	Aldo Keto reductase
HG536_0B00290	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HG536_0B00480	COG3118	belongs to the thioredoxin family
HG536_0B00590	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HG536_0B00640	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HG536_0B00700	COG0833	amino acid
HG536_0B00720	COG2815	serine threonine protein kinase
HG536_0B00720	COG0515	serine threonine protein kinase
HG536_0B00730	COG2132	Multicopper oxidase
HG536_0B00730	COG2132	Multicopper oxidase
HG536_0B00850	COG1132	(ABC) transporter
HG536_0B00860	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HG536_0B00870	COG1819	glycosyl
HG536_0B00930	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HG536_0B01020	COG0833	amino acid
HG536_0B01030	COG0833	amino acid
HG536_0B01100	COG0484	heat shock protein binding
HG536_0B01210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HG536_0B01220	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HG536_0B01280	COG1196	nuclear chromosome segregation
HG536_0B01330	COG0215	cysteine-tRNA ligase activity
HG536_0B01520	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HG536_0B01560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HG536_0B01590	COG0753	catalase activity
HG536_0B01870	COG1113	amino acid transport
HG536_0B01900	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HG536_0B01960	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HG536_0B02020	COG2895	sulfate adenylyltransferase (ATP) activity
HG536_0B02060	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HG536_0B02070	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HG536_0B02100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG536_0B02210	COG0316	Belongs to the HesB IscA family
HG536_0B02290	COG0484	heat shock protein binding
HG536_0B02590	COG0187	DNA topoisomerase II activity
HG536_0B02640	COG0459	protein refolding
HG536_0B02760	COG0484	heat shock protein binding
HG536_0B02820	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HG536_0B02830	COG0508	dehydrogenase complex catalyzes the overall conversion of
HG536_0B02930	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG536_0B02940	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HG536_0B03000	COG2814	Major facilitator Superfamily
HG536_0B03010	COG0484	heat shock protein binding
HG536_0B03030	COG2890	protein-(glutamine-N5) methyltransferase activity
HG536_0B03050	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HG536_0B03050	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HG536_0B03110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HG536_0B03330	COG0288	reversible hydration of carbon dioxide
HG536_0B03360	COG0473	3-isopropylmalate dehydrogenase activity
HG536_0B03420	COG0142	geranyltranstransferase activity
HG536_0B03450	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HG536_0B03460	COG0515	serine threonine protein kinase
HG536_0B03490	COG0515	serine threonine protein kinase
HG536_0B03520	COG0484	heat shock protein binding
HG536_0B03760	COG1953	Uracil, thiamine, allantoin
HG536_0B03830	COG0504	CTP synthase activity
HG536_0B03900	COG0656	L-ascorbic acid biosynthetic process
HG536_0B04180	COG2815	serine threonine protein kinase
HG536_0B04180	COG0515	serine threonine protein kinase
HG536_0B04290	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HG536_0B04320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HG536_0B04340	COG2814	Major facilitator Superfamily
HG536_0B04400	COG0024	Methionine aminopeptidase
HG536_0B04600	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HG536_0B04650	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HG536_0B04660	COG3474	cytochrome
HG536_0B04680	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HG536_0B04740	COG1053	succinate dehydrogenase
HG536_0B04860	COG2814	Major facilitator Superfamily
HG536_0B04900	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HG536_0B04910	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HG536_0B04910	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HG536_0B04920	COG4285	Biotin-protein ligase, N terminal
HG536_0B04930	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HG536_0B04940	COG0459	protein refolding
HG536_0B05120	COG2815	serine threonine protein kinase
HG536_0B05120	COG0515	serine threonine protein kinase
HG536_0B05140	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HG536_0B05190	COG1793	dna ligase
HG536_0B05360	COG0067	glutamate synthase
HG536_0B05360	COG0069	glutamate synthase activity
HG536_0B05360	COG0070	glutamate synthase
HG536_0B05390	COG0277	FAD linked oxidase domain protein
HG536_0B05440	COG0442	prolyl-tRNA aminoacylation
HG536_0B05540	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HG536_0B05610	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HG536_0B05630	COG0450	alkyl hydroperoxide reductase
HG536_0B05660	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HG536_0B05720	COG0443	Heat shock 70 kDa protein
HG536_0B05730	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HG536_0B05810	COG0443	Heat shock 70 kDa protein
HG536_0B05830	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HG536_0B05870	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG536_0B05950	COG0228	four-way junction DNA binding
HG536_0B06030	COG0513	Belongs to the DEAD box helicase family
HG536_0B06040	COG0101	tRNA pseudouridine synthase activity
HG536_0B06140	COG0006	proline dipeptidase activity
HG536_0B06250	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HG536_0B06310	COG1196	nuclear chromosome segregation
HG536_0B06340	COG0833	amino acid
HG536_0B06400	COG0484	heat shock protein binding
HG536_0B06450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HG536_0B06640	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HG536_0B06670	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HG536_0B06800	COG2814	Major facilitator Superfamily
HG536_0B06850	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HG536_0B06860	COG2132	Multicopper oxidase
HG536_0B06870	COG1063	alcohol dehydrogenase
HG536_0B07080	COG0667	Aldo Keto reductase
HG536_0B07100	COG2249	NAD(P)H dehydrogenase (quinone) activity
HG536_0C00100	COG0596	Alpha beta hydrolase
HG536_0C00120	COG1902	pentaerythritol trinitrate reductase activity
HG536_0C00180	COG0446	pyridine nucleotide-disulphide oxidoreductase
HG536_0C00200	COG0167	dihydroorotate dehydrogenase activity
HG536_0C00230	COG0183	Belongs to the thiolase family
HG536_0C00340	COG0459	protein refolding
HG536_0C00380	COG3844	kynureninase activity
HG536_0C00410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HG536_0C00480	COG0321	lipoyl(octanoyl) transferase activity
HG536_0C00510	COG0237	dephospho-CoA kinase activity
HG536_0C00530	COG0513	Belongs to the DEAD box helicase family
HG536_0C00590	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HG536_0C00630	COG0024	Methionine aminopeptidase
HG536_0C00640	COG0295	cytidine deaminase activity
HG536_0C00790	COG0612	Peptidase, M16
HG536_0C01020	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HG536_0C01140	COG0833	amino acid
HG536_0C01400	COG0400	carboxylic ester hydrolase activity
HG536_0C01420	COG2890	protein-(glutamine-N5) methyltransferase activity
HG536_0C01510	COG1132	(ABC) transporter
HG536_0C01520	COG0515	serine threonine protein kinase
HG536_0C01520	COG2815	serine threonine protein kinase
HG536_0C01710	COG2267	carboxylic ester hydrolase activity
HG536_0C01750	COG2815	serine threonine protein kinase
HG536_0C01750	COG0515	serine threonine protein kinase
HG536_0C01820	COG2814	Major facilitator Superfamily
HG536_0C01860	COG0081	regulation of translation
HG536_0C01900	COG0484	heat shock protein binding
HG536_0C01950	COG1196	nuclear chromosome segregation
HG536_0C02080	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HG536_0C02220	COG0004	ammonium transporteR
HG536_0C02400	COG3346	SURF1 family
HG536_0C02440	COG0596	Alpha beta hydrolase
HG536_0C02480	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HG536_0C02570	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HG536_0C02650	COG0515	serine threonine protein kinase
HG536_0C02650	COG2815	serine threonine protein kinase
HG536_0C02660	COG0488	(ABC) transporter
HG536_0C02690	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HG536_0C02710	COG0538	isocitrate dehydrogenase activity
HG536_0C02720	COG0440	acetolactate synthase activity
HG536_0C02730	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HG536_0C02750	COG0724	RNA recognition motif
HG536_0C02800	COG1104	cysteine desulfurase activity
HG536_0C02810	COG0473	3-isopropylmalate dehydrogenase activity
HG536_0C02850	COG0484	heat shock protein binding
HG536_0C02860	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HG536_0C03030	COG1584	GPR1 FUN34 yaaH family protein
HG536_0C03060	COG1716	ATPase activity
HG536_0C03060	COG1131	(ABC) transporter
HG536_0C03060	COG0842	Transport permease protein
HG536_0C03070	COG0126	phosphoglycerate kinase activity
HG536_0C03100	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HG536_0C03120	COG0318	PFAM AMP-dependent synthetase and ligase
HG536_0C03150	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HG536_0C03170	COG0572	uridine kinase
HG536_0C03200	COG1028	Short-chain dehydrogenase reductase Sdr
HG536_0C03210	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HG536_0C03310	COG0655	NAD(P)H dehydrogenase (quinone) activity
HG536_0C03370	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HG536_0C03400	COG1024	Enoyl-CoA hydratase
HG536_0C03440	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HG536_0C03450	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HG536_0C03460	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HG536_0C03470	COG0051	transcription antitermination factor activity, RNA binding
HG536_0C03520	COG0408	coproporphyrinogen oxidase activity
HG536_0C03560	COG0149	triose-phosphate isomerase activity
HG536_0C03620	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HG536_0C03700	COG0154	amidase activity
HG536_0C03730	COG1222	aaa ATPase
HG536_0C03890	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HG536_0C03980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HG536_0C04010	COG0217	transcriptional regulatory protein
HG536_0C04080	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HG536_0C04140	COG1643	Atp-dependent helicase
HG536_0C04170	COG1022	Amp-dependent synthetase and ligase
HG536_0C04190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG536_0C04220	COG0756	dUTP diphosphatase activity
HG536_0C04300	COG0307	riboflavin synthase, alpha
HG536_0C04340	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HG536_0C04350	COG1196	nuclear chromosome segregation
HG536_0C04530	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG536_0C04540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HG536_0C04540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HG536_0C04570	COG0515	serine threonine protein kinase
HG536_0C04570	COG2815	serine threonine protein kinase
HG536_0C04640	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG536_0C04660	COG0484	heat shock protein binding
HG536_0C04710	COG2205	protein histidine kinase activity
HG536_0C04820	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HG536_0C04840	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HG536_0C04880	COG0251	oxidation-reduction process
HG536_0C04910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HG536_0C04920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HG536_0C04950	COG2224	Isocitrate lyase
HG536_0C05000	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HG536_0C05050	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HG536_0C05050	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HG536_0C05100	COG1012	belongs to the aldehyde dehydrogenase family
HG536_0C05170	COG0006	proline dipeptidase activity
HG536_0C05220	COG1902	pentaerythritol trinitrate reductase activity
HG536_0C05230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HG536_0C05260	COG0167	dihydroorotate dehydrogenase activity
HG536_0C05300	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HG536_0C05350	COG0277	FAD linked oxidase domain protein
HG536_0C05360	COG0537	adenosine 5'-monophosphoramidase activity
HG536_0C05370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG536_0C05440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HG536_0C05480	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HG536_0C05500	COG1643	Atp-dependent helicase
HG536_0C05540	COG0418	dihydroorotase activity
HG536_0C05560	COG1546	Belongs to the CinA family
HG536_0C05560	COG1058	Belongs to the CinA family
HG536_0C05650	COG1304	FMN binding
HG536_0C05780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HG536_0C05830	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HG536_0C06180	COG0626	cystathionine gamma-synthase activity
HG536_0C06330	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HG536_0C06370	COG0527	aspartate kinase activity
HG536_0C06370	COG0460	homoserine dehydrogenase
HG536_0C06480	COG0745	RESPONSE REGULATOR receiver
HG536_0C06510	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HG536_0C06520	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HG536_0D00120	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HG536_0D00140	COG2814	Major facilitator Superfamily
HG536_0D00150	COG2017	converts alpha-aldose to the beta-anomer
HG536_0D00210	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HG536_0D00220	COG4624	Iron only hydrogenase large subunit, C-terminal domain
HG536_0D00220	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HG536_0D00330	COG0484	heat shock protein binding
HG536_0D00380	COG0402	S-adenosylhomocysteine deaminase activity
HG536_0D00410	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HG536_0D00440	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HG536_0D00460	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HG536_0D00590	COG0443	Heat shock 70 kDa protein
HG536_0D00660	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HG536_0D00660	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HG536_0D00750	COG1490	D-aminoacyl-tRNA deacylase activity
HG536_0D00850	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HG536_0D00910	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HG536_0D00990	COG0166	Belongs to the GPI family
HG536_0D01040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG536_0D01220	COG1012	belongs to the aldehyde dehydrogenase family
HG536_0D01230	COG0596	Alpha beta hydrolase
HG536_0D01230	COG0508	dehydrogenase complex catalyzes the overall conversion of
HG536_0D01320	COG0505	Belongs to the CarA family
HG536_0D01420	COG0328	RNA-DNA hybrid ribonuclease activity
HG536_0D01540	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG536_0D01550	COG4221	oxidoreductase activity
HG536_0D01630	COG0406	alpha-ribazole phosphatase activity
HG536_0D01750	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HG536_0D01750	COG0519	Catalyzes the synthesis of GMP from XMP
HG536_0D01770	COG0484	heat shock protein binding
HG536_0D01820	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HG536_0D01830	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HG536_0D01890	COG1160	GTP binding
HG536_0D01920	COG0386	Belongs to the glutathione peroxidase family
HG536_0D01940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HG536_0D01970	COG2814	Major facilitator Superfamily
HG536_0D01990	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG536_0D01990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG536_0D02040	COG0513	Belongs to the DEAD box helicase family
HG536_0D02130	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HG536_0D02170	COG0672	)-iron permease
HG536_0D02250	COG1612	heme a metabolic process
HG536_0D02310	COG0156	8-amino-7-oxononanoate synthase activity
HG536_0D02320	COG1119	ATPase activity
HG536_0D02370	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HG536_0D02370	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HG536_0D02400	COG1012	belongs to the aldehyde dehydrogenase family
HG536_0D02410	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HG536_0D02470	COG0515	serine threonine protein kinase
HG536_0D02480	COG0427	acetyl-CoA hydrolase
HG536_0D02560	COG0123	including yeast histone deacetylase and acetoin utilization protein
HG536_0D02630	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HG536_0D02650	COG0626	cystathionine gamma-synthase activity
HG536_0D02810	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HG536_0D02920	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HG536_0D02950	COG1063	alcohol dehydrogenase
HG536_0D02980	COG1444	tRNA N-acetyltransferase activity
HG536_0D03090	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HG536_0D03130	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HG536_0D03190	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HG536_0D03270	COG0513	Belongs to the DEAD box helicase family
HG536_0D03390	COG0417	DNA replication proofreading
HG536_0D03520	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HG536_0D03560	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HG536_0D03590	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HG536_0D03630	COG0017	Asparaginyl-tRNA synthetase
HG536_0D03720	COG0443	Heat shock 70 kDa protein
HG536_0D03750	COG0542	response to heat
HG536_0D03760	COG0316	Belongs to the HesB IscA family
HG536_0D03770	COG2814	Major facilitator Superfamily
HG536_0D03890	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HG536_0D03900	COG0724	RNA recognition motif
HG536_0D03950	COG0463	Glycosyl transferase, family 2
HG536_0D03970	COG0488	(ABC) transporter
HG536_0D03980	COG1546	Belongs to the CinA family
HG536_0D03980	COG1058	Belongs to the CinA family
HG536_0D04050	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HG536_0D04070	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG536_0D04070	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG536_0D04150	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HG536_0D04270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HG536_0D04360	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HG536_0D04380	COG1064	alcohol dehydrogenase
HG536_0D04470	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HG536_0D04500	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HG536_0D04510	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HG536_0D04590	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HG536_0D04620	COG0133	tryptophan synthase activity
HG536_0D04820	COG1335	isochorismatase
HG536_0D04900	COG0833	amino acid
HG536_0D04920	COG0724	RNA recognition motif
HG536_0D04970	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HG536_0D05080	COG0200	Binds to the 23S rRNA
HG536_0D05130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HG536_0D05140	COG0058	SHG alpha-glucan phosphorylase activity
HG536_0D05170	COG0517	IMP dehydrogenase activity
HG536_0D05170	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HG536_0D05210	COG2814	Major facilitator Superfamily
HG536_0D05400	COG0659	secondary active sulfate transmembrane transporter activity
HG536_0D05410	COG0367	asparagine synthase
HG536_0D05430	COG1183	phosphatidylcholine synthase activity
HG536_0D05540	COG0037	tRNA processing
HG536_0D05640	COG0488	(ABC) transporter
HG536_0D05750	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HG536_0D05780	COG0484	heat shock protein binding
HG536_0D05870	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HG536_0D05930	COG0157	Belongs to the NadC ModD family
HG536_0D05990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HG536_0D06090	COG0248	Ppx GppA phosphatase
HG536_0D06130	COG2814	Major facilitator Superfamily
HG536_0D06140	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HG536_0D06150	COG0798	PFAM Bile acid sodium symporter
HG536_0D06160	COG1902	pentaerythritol trinitrate reductase activity
HG536_0D06170	COG0667	Aldo Keto reductase
HG536_0D06180	COG1028	Short-chain dehydrogenase reductase Sdr
HG536_0D06190	COG0667	Aldo Keto reductase
HG536_0D06230	COG2249	NAD(P)H dehydrogenase (quinone) activity
HG536_0E00110	COG0667	Aldo Keto reductase
HG536_0E00190	COG0415	Belongs to the DNA photolyase family
HG536_0E00270	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HG536_0E00280	COG0123	including yeast histone deacetylase and acetoin utilization protein
HG536_0E00290	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG536_0E00370	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HG536_0E00410	COG1073	alpha beta
HG536_0E00430	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG536_0E00470	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HG536_0E00490	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HG536_0E00500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HG536_0E00550	COG0018	arginyl-trna synthetase
HG536_0E00560	COG2814	Major facilitator Superfamily
HG536_0E00570	COG2814	Major facilitator Superfamily
HG536_0E00720	COG0656	L-ascorbic acid biosynthetic process
HG536_0E00790	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HG536_0E00890	COG0626	cystathionine gamma-synthase activity
HG536_0E00900	COG1362	aminopeptidase activity
HG536_0E00920	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HG536_0E01000	COG0656	L-ascorbic acid biosynthetic process
HG536_0E01050	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HG536_0E01070	COG0450	alkyl hydroperoxide reductase
HG536_0E01080	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HG536_0E01250	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HG536_0E01250	COG0047	phosphoribosylformylglycinamidine synthase activity
HG536_0E01360	COG0443	Heat shock 70 kDa protein
HG536_0E01510	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HG536_0E01530	COG2365	Tyrosine phosphatase family
HG536_0E01560	COG0495	leucyl-tRNA aminoacylation
HG536_0E01570	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HG536_0E01750	COG0538	isocitrate dehydrogenase activity
HG536_0E01820	COG4581	dead DEAH box helicase
HG536_0E01900	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HG536_0E01990	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HG536_0E02010	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HG536_0E02030	COG0019	diaminopimelate decarboxylase activity
HG536_0E02070	COG4178	(ABC) transporter
HG536_0E02110	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HG536_0E02130	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HG536_0E02340	COG0039	L-malate dehydrogenase activity
HG536_0E02350	COG0670	Belongs to the BI1 family
HG536_0E02360	COG0089	rRNA binding
HG536_0E02560	COG2814	Major facilitator Superfamily
HG536_0E02570	COG0724	RNA recognition motif
HG536_0E02620	COG0556	nucleotide-excision repair
HG536_0E02630	COG0515	serine threonine protein kinase
HG536_0E02630	COG2815	serine threonine protein kinase
HG536_0E02890	COG1657	PFAM Prenyltransferase squalene oxidase
HG536_0E02960	COG2226	methyltransferase
HG536_0E03040	COG0443	Heat shock 70 kDa protein
HG536_0E03050	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HG536_0E03210	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HG536_0E03300	COG1012	belongs to the aldehyde dehydrogenase family
HG536_0E03310	COG0557	exoribonuclease II activity
HG536_0E03380	COG1111	helicase
HG536_0E03380	COG1205	dead DEAH box helicase
HG536_0E03460	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HG536_0E03550	COG1914	H( )-stimulated, divalent metal cation uptake system
HG536_0E03610	COG0534	Mate efflux family protein
HG536_0E03620	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HG536_0E03640	COG0384	phenazine biosynthesis protein PhzF
HG536_0E03650	COG1506	peptidase
HG536_0E03650	COG0823	Involved in the tonB-independent uptake of proteins
HG536_0E03680	COG0083	homoserine kinase activity
HG536_0E03690	COG0612	Peptidase, M16
HG536_0E03800	COG0588	phosphoglycerate mutase activity
HG536_0E03810	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HG536_0E03840	COG1053	succinate dehydrogenase
HG536_0E03860	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG536_0E03910	COG0459	protein refolding
HG536_0E03980	COG0443	Heat shock 70 kDa protein
HG536_0E04030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HG536_0E04310	COG0513	Belongs to the DEAD box helicase family
HG536_0E04470	COG0180	Tryptophanyl-tRNA synthetase
HG536_0E04590	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HG536_0E04600	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG536_0E04620	COG0477	Major facilitator Superfamily
HG536_0E04630	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG536_0E04650	COG0688	phosphatidylethanolamine metabolic process
HG536_0E04690	COG0564	pseudouridine synthase activity
HG536_0E04770	COG0459	protein refolding
HG536_0E04780	COG0515	serine threonine protein kinase
HG536_0E04780	COG4991	sh3 domain protein
HG536_0E04780	COG3064	Membrane
HG536_0E04830	COG1185	polyribonucleotide nucleotidyltransferase activity
HG536_0E04860	COG2046	Belongs to the sulfate adenylyltransferase family
HG536_0E04860	COG0529	Catalyzes the synthesis of activated sulfate
HG536_0E04870	COG0508	dehydrogenase complex catalyzes the overall conversion of
HG536_0E05040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HG536_0E05050	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HG536_0E05100	COG0235	Class ii aldolase
HG536_0E05110	COG0662	Cupin 2, conserved barrel domain protein
HG536_0E05140	COG0560	Phosphoserine phosphatase
HG536_0E05150	COG3118	belongs to the thioredoxin family
HG536_0E05150	COG0492	ferredoxin-NADP+ reductase activity
HG536_0E05180	COG3961	Belongs to the TPP enzyme family
HG536_0E05190	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG536_0E05310	COG0222	ribosome binding
HG536_0E05320	COG0515	serine threonine protein kinase
HG536_0E05410	COG0515	serine threonine protein kinase
HG536_0E05410	COG2815	serine threonine protein kinase
HG536_0E05420	COG0513	Belongs to the DEAD box helicase family
HG536_0E05500	COG0352	thiamine-phosphate diphosphorylase activity
HG536_0E05610	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HG536_0E05680	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HG536_0E05700	COG1132	(ABC) transporter
HG536_0E05710	COG2873	o-acetylhomoserine
HG536_0E05750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG536_0E05780	COG2271	Major facilitator Superfamily
HG536_0E05810	COG2814	Major facilitator Superfamily
HG536_0E05850	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HG536_0E05880	COG0833	amino acid
HG536_0E05900	COG0656	L-ascorbic acid biosynthetic process
HG536_0E05940	COG1028	Short-chain dehydrogenase reductase Sdr
HG536_0E05950	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HG536_0E05960	COG0667	Aldo Keto reductase
HG536_0E05970	COG0667	Aldo Keto reductase
HG536_0F00100	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HG536_0F00120	COG0667	Aldo Keto reductase
HG536_0F00130	COG0039	L-malate dehydrogenase activity
HG536_0F00140	COG3961	Belongs to the TPP enzyme family
HG536_0F00170	COG0523	cobalamin synthesis protein
HG536_0F00180	COG0110	maltose O-acetyltransferase activity
HG536_0F00190	COG1028	Short-chain dehydrogenase reductase Sdr
HG536_0F00230	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
HG536_0F00530	COG0175	sulfate reduction
HG536_0F00540	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HG536_0F00670	COG0049	tRNA binding
HG536_0F00690	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HG536_0F00700	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HG536_0F00770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HG536_0F00810	COG0401	homolog of Blt101
HG536_0F00900	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HG536_0F01080	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HG536_0F01090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HG536_0F01130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HG536_0F01190	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HG536_0F01290	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HG536_0F01300	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HG536_0F01370	COG0515	serine threonine protein kinase
HG536_0F01370	COG2815	serine threonine protein kinase
HG536_0F01450	COG0459	protein refolding
HG536_0F01480	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HG536_0F01530	COG3743	rRNA binding
HG536_0F01530	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HG536_0F01550	COG0475	glutathione-regulated potassium exporter activity
HG536_0F01610	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HG536_0F01710	COG0481	GTPase activity
HG536_0F01760	COG1196	nuclear chromosome segregation
HG536_0F01780	COG0484	heat shock protein binding
HG536_0F01960	COG0203	ribosomal protein L17
HG536_0F02040	COG0436	Aminotransferase
HG536_0F02070	COG0515	serine threonine protein kinase
HG536_0F02180	COG0515	serine threonine protein kinase
HG536_0F02210	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HG536_0F02290	COG0095	Lipoate-protein ligase
HG536_0F02340	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HG536_0F02350	COG0017	Asparaginyl-tRNA synthetase
HG536_0F02360	COG0165	Argininosuccinate lyase
HG536_0F02400	COG1252	NADH dehydrogenase
HG536_0F02480	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HG536_0F02500	COG0488	(ABC) transporter
HG536_0F02510	COG0557	exoribonuclease II activity
HG536_0F02590	COG3961	Belongs to the TPP enzyme family
HG536_0F02600	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HG536_0F02670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG536_0F02740	COG3469	chitinase activity
HG536_0F02740	COG3325	Belongs to the glycosyl hydrolase 18 family
HG536_0F02770	COG2350	Protein conserved in bacteria
HG536_0F02920	COG0656	L-ascorbic acid biosynthetic process
HG536_0F02990	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG536_0F03100	COG0489	protein tyrosine kinase activity
HG536_0F03190	COG0724	RNA recognition motif
HG536_0F03210	COG1482	cell wall glycoprotein biosynthetic process
HG536_0F03300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HG536_0F03340	COG0484	heat shock protein binding
HG536_0F03420	COG1716	ATPase activity
HG536_0F03420	COG0842	Transport permease protein
HG536_0F03420	COG1131	(ABC) transporter
HG536_0F03540	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HG536_0F03650	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HG536_0F03660	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HG536_0F03690	COG0626	cystathionine gamma-synthase activity
HG536_0F03720	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HG536_0F03960	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HG536_0F04120	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HG536_0F04190	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HG536_0F04200	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HG536_0F04200	COG3266	domain, Protein
HG536_0F04210	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG536_0F04240	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HG536_0F04260	COG1113	amino acid transport
HG536_0F04450	COG0509	glycine decarboxylation via glycine cleavage system
HG536_0F04460	COG1902	pentaerythritol trinitrate reductase activity
HG536_0F04670	COG1012	belongs to the aldehyde dehydrogenase family
HG536_0F04700	COG1063	alcohol dehydrogenase
HG536_0F04710	COG1063	alcohol dehydrogenase
HG536_0F04720	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HG536_0F04730	COG4221	oxidoreductase activity
HG536_0G00110	COG0667	Aldo Keto reductase
HG536_0G00170	COG0563	adenylate kinase activity
HG536_0G00220	COG0666	response to abiotic stimulus
HG536_0G00280	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HG536_0G00390	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HG536_0G00440	COG0039	L-malate dehydrogenase activity
HG536_0G00560	COG1643	Atp-dependent helicase
HG536_0G00570	COG2814	Major facilitator Superfamily
HG536_0G00580	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HG536_0G00680	COG0443	Heat shock 70 kDa protein
HG536_0G00720	COG1956	GAF domain-containing protein
HG536_0G00800	COG0105	UTP biosynthetic process
HG536_0G01010	COG1028	Short-chain dehydrogenase reductase Sdr
HG536_0G01100	COG0191	fructose-bisphosphate aldolase activity
HG536_0G01150	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HG536_0G01370	COG0012	GTP binding
HG536_0G01500	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HG536_0G01600	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HG536_0G01630	COG0525	valine-tRNA ligase activity
HG536_0G01660	COG0515	serine threonine protein kinase
HG536_0G01800	COG0515	serine threonine protein kinase
HG536_0G01880	COG0724	RNA recognition motif
HG536_0G01970	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG536_0G01970	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG536_0G02000	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HG536_0G02040	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HG536_0G02040	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HG536_0G02080	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HG536_0G02150	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HG536_0G02150	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HG536_0G02540	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HG536_0G02600	COG0483	inositol monophosphate 1-phosphatase activity
HG536_0G02610	COG0482	sulfurtransferase activity
HG536_0G02620	COG0513	Belongs to the DEAD box helicase family
HG536_0G02680	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HG536_0G02700	COG1253	flavin adenine dinucleotide binding
HG536_0G02710	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HG536_0G02720	COG0137	argininosuccinate synthase activity
HG536_0G02730	COG0588	phosphoglycerate mutase activity
HG536_0G02750	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HG536_0G02750	COG0351	phosphomethylpyrimidine kinase
HG536_0G02750	COG0352	thiamine-phosphate diphosphorylase activity
HG536_0G02780	COG0515	serine threonine protein kinase
HG536_0G02780	COG2815	serine threonine protein kinase
HG536_0G02790	COG2815	serine threonine protein kinase
HG536_0G02790	COG0515	serine threonine protein kinase
HG536_0G02800	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HG536_0G02850	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HG536_0G02870	COG0515	serine threonine protein kinase
HG536_0G02870	COG4991	sh3 domain protein
HG536_0G02870	COG3064	Membrane
HG536_0G02940	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HG536_0G02950	COG0135	phosphoribosylanthranilate isomerase activity
HG536_0G03020	COG1012	belongs to the aldehyde dehydrogenase family
HG536_0G03050	COG0142	geranyltranstransferase activity
HG536_0G03060	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HG536_0G03160	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HG536_0G03190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG536_0G03200	COG1716	ATPase activity
HG536_0G03200	COG0842	Transport permease protein
HG536_0G03200	COG1131	(ABC) transporter
HG536_0G03210	COG1953	Uracil, thiamine, allantoin
HG536_0G03250	COG1999	signal sequence binding
HG536_0G03290	COG0515	serine threonine protein kinase
HG536_0G03300	COG0575	Belongs to the CDS family
HG536_0G03320	COG0088	Forms part of the polypeptide exit tunnel
HG536_0G03360	COG0259	pyridoxamine-phosphate oxidase activity
HG536_0G03460	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HG536_0G03550	COG1028	Short-chain dehydrogenase reductase Sdr
HG536_0G03620	COG0028	Belongs to the TPP enzyme family
HG536_0G03670	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HG536_0G03700	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG536_0G03820	COG0009	L-threonylcarbamoyladenylate synthase
HG536_0G03840	COG0085	RNA polymerase activity
HG536_0G03850	COG2233	PERMEase
HG536_0G03950	COG0513	Belongs to the DEAD box helicase family
HG536_0G04110	COG2815	serine threonine protein kinase
HG536_0G04110	COG0515	serine threonine protein kinase
HG536_0G04130	COG3266	domain, Protein
HG536_0G04130	COG0515	serine threonine protein kinase
HG536_0G04140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HG536_0G04200	COG0515	serine threonine protein kinase
HG536_0G04240	COG0481	GTPase activity
HG536_0G04310	COG0179	Fumarylacetoacetate (FAA) hydrolase
HG536_0G04320	COG2131	deaminase
HG536_0G04330	COG0688	phosphatidylethanolamine metabolic process
HG536_0G04360	COG0724	RNA recognition motif
HG536_0G04470	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HG536_0G04560	COG0459	protein refolding
HG536_0G04610	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HG536_0G04640	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HG536_0G04700	COG2226	methyltransferase
HG536_0G04720	COG1132	(ABC) transporter
HG536_0G04730	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HG536_0G04770	COG0512	Glutamine amidotransferase of anthranilate synthase
HG536_0G04810	COG0423	glycine-tRNA ligase activity
HG536_0G04870	COG0277	FAD linked oxidase domain protein
HG536_0G04880	COG2040	homocysteine
HG536_0G04890	COG0626	cystathionine gamma-synthase activity
HG536_0G04900	COG2808	Putative FMN-binding domain
HG536_0G04910	COG1017	nitric oxide dioxygenase activity
HG536_0G04910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HG536_0G04930	COG0667	Aldo Keto reductase
HG536_0G04980	COG0596	Alpha beta hydrolase
HG536_0H00130	COG0488	(ABC) transporter
HG536_0H00170	COG2271	Major facilitator Superfamily
HG536_0H00220	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HG536_0H00230	COG1252	NADH dehydrogenase
HG536_0H00250	COG0193	aminoacyl-tRNA hydrolase activity
HG536_0H00270	COG0477	Major facilitator Superfamily
HG536_0H00310	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HG536_0H00330	COG3425	synthase
HG536_0H00500	COG0571	ribonuclease III activity
HG536_0H00520	COG0483	inositol monophosphate 1-phosphatase activity
HG536_0H00540	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HG536_0H00580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HG536_0H00720	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HG536_0H00860	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HG536_0H00980	COG0076	glutamate decarboxylase activity
HG536_0H01090	COG1230	cation diffusion facilitator family transporter
HG536_0H01220	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HG536_0H01240	COG1131	(ABC) transporter
HG536_0H01240	COG1716	ATPase activity
HG536_0H01240	COG0842	Transport permease protein
HG536_0H01280	COG2815	serine threonine protein kinase
HG536_0H01280	COG0515	serine threonine protein kinase
HG536_0H01400	COG1785	Belongs to the alkaline phosphatase family
HG536_0H01500	COG0724	RNA recognition motif
HG536_0H01510	COG0515	serine threonine protein kinase
HG536_0H01530	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HG536_0H01610	COG0183	Belongs to the thiolase family
HG536_0H01620	COG3265	gluconokinase activity
HG536_0H01660	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HG536_0H01710	COG0513	Belongs to the DEAD box helicase family
HG536_0H01720	COG0154	amidase activity
HG536_0H01780	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HG536_0H01830	COG0181	hydroxymethylbilane synthase activity
HG536_0H01840	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HG536_0H01860	COG0156	8-amino-7-oxononanoate synthase activity
HG536_0H01910	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HG536_0H01930	COG2814	Major facilitator Superfamily
HG536_0H01980	COG0563	adenylate kinase activity
HG536_0H02120	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HG536_0H02150	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HG536_0H02270	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HG536_0H02380	COG1028	Short-chain dehydrogenase reductase Sdr
HG536_0H02420	COG1643	Atp-dependent helicase
HG536_0H02470	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HG536_0H02540	COG1234	tRNA 3'-trailer cleavage
HG536_0H02580	COG0435	Glutathione S-transferase
HG536_0H02590	COG2857	Cytochrome c1
HG536_0H02590	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HG536_0H02610	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HG536_0H02700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HG536_0H02740	COG1648	precorrin-2 dehydrogenase activity
HG536_0H02740	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HG536_0H02830	COG0401	homolog of Blt101
HG536_0H02880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HG536_0H02900	COG2119	membrane
HG536_0H02910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG536_0H02920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HG536_0H02960	COG2226	methyltransferase
HG536_0H02970	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HG536_0H03020	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HG536_0H03040	COG0617	tRNA 3'-terminal CCA addition
HG536_0H03040	COG0517	IMP dehydrogenase activity
HG536_0H03040	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HG536_0H03090	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG536_0H03100	COG1129	ABC transporter
HG536_0H03220	COG2351	hydroxyisourate hydrolase activity
HG536_0H03300	COG0706	membrane insertase activity
HG536_0H03320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HG536_0H03490	COG1643	Atp-dependent helicase
HG536_0H03520	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HG536_0H03580	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HG536_0H03600	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HG536_0H03630	COG0022	dehydrogenase e1 component
HG536_0H03630	COG0508	dehydrogenase complex catalyzes the overall conversion of
HG536_0H03770	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HG536_0H03770	COG1648	precorrin-2 dehydrogenase activity
HG536_0H03780	COG0724	RNA recognition motif
HG536_0H03820	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG536_0H03830	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HG536_0H03860	COG0405	Gamma-glutamyltransferase
HG536_0H03870	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HG536_0H03950	COG0481	GTPase activity
HG536_0H04050	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HG536_0H04080	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HG536_0H04140	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HG536_0H04290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HG536_0H04330	COG0459	protein refolding
HG536_0H04480	COG0515	serine threonine protein kinase
HG536_0H04560	COG1741	Belongs to the pirin family
HG536_0H04670	COG0114	fumarate hydratase activity
HG536_0H04690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HG536_0H04750	COG1132	(ABC) transporter
HG536_0H04790	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HG536_0H04820	COG0833	amino acid
HG536_0H04850	COG1621	beta-fructofuranosidase activity
HG536_0H04870	COG1454	alcohol dehydrogenase
HG536_0H04890	COG0405	Gamma-glutamyltransferase
HG536_0H04930	COG1902	pentaerythritol trinitrate reductase activity