locus-tag	class	description
TREBR_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TREBR_RS00010	COG0592	DNA-directed DNA polymerase activity
TREBR_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TREBR_RS00025	COG0594	ribonuclease P activity
TREBR_RS00030	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TREBR_RS00035	COG0706	membrane insertase activity
TREBR_RS00040	COG1847	R3H domain protein
TREBR_RS00050	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TREBR_RS00080	COG2885	chlorophyll binding
TREBR_RS00085	COG1904	glucuronate isomerase
TREBR_RS00090	COG2721	sulfolactate sulfo-lyase activity
TREBR_RS00095	COG0246	Mannitol dehydrogenase
TREBR_RS00100	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TREBR_RS00100	COG2207	Transcriptional regulator
TREBR_RS00105	COG4209	transmembrane transport
TREBR_RS00110	COG0395	ABC-type sugar transport system, permease component
TREBR_RS00115	COG1653	transport
TREBR_RS00155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TREBR_RS00170	COG0622	Phosphoesterase
TREBR_RS00175	COG1959	2 iron, 2 sulfur cluster binding
TREBR_RS00180	COG0076	glutamate decarboxylase activity
TREBR_RS00210	COG1486	melibiose metabolic process
TREBR_RS00220	COG1175	transmembrane transport
TREBR_RS00225	COG0395	ABC-type sugar transport system, permease component
TREBR_RS00240	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TREBR_RS00265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TREBR_RS00290	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TREBR_RS00295	COG0384	phenazine biosynthesis protein PhzF
TREBR_RS00310	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TREBR_RS00315	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
TREBR_RS00320	COG0737	Belongs to the 5'-nucleotidase family
TREBR_RS00325	COG1609	Transcriptional regulator
TREBR_RS00330	COG3845	ABC transporter
TREBR_RS00335	COG4603	Belongs to the binding-protein-dependent transport system permease family
TREBR_RS00340	COG1079	Belongs to the binding-protein-dependent transport system permease family
TREBR_RS00345	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TREBR_RS00350	COG1744	ABC transporter substrate-binding protein PnrA-like
TREBR_RS00355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TREBR_RS00370	COG0454	-acetyltransferase
TREBR_RS00415	COG1131	(ABC) transporter
TREBR_RS00435	COG0246	Mannitol dehydrogenase
TREBR_RS00440	COG1312	Catalyzes the dehydration of D-mannonate
TREBR_RS00445	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TREBR_RS00450	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TREBR_RS00455	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TREBR_RS00460	COG1063	alcohol dehydrogenase
TREBR_RS00465	COG1063	alcohol dehydrogenase
TREBR_RS00470	COG1802	Transcriptional regulator
TREBR_RS00475	COG1028	Short-chain dehydrogenase reductase Sdr
TREBR_RS00495	COG2201	protein-glutamate methylesterase activity
TREBR_RS00505	COG0643	Histidine kinase
TREBR_RS00505	COG2198	Histidine kinase
TREBR_RS00515	COG0835	chemotaxis
TREBR_RS00520	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TREBR_RS00530	COG0455	bacterial-type flagellum organization
TREBR_RS00535	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TREBR_RS00545	COG0372	Belongs to the citrate synthase family
TREBR_RS00555	COG4254	PFAM FecR protein
TREBR_RS00575	COG3250	beta-galactosidase activity
TREBR_RS00595	COG2197	response regulator
TREBR_RS00605	COG1454	alcohol dehydrogenase
TREBR_RS00615	COG1070	Carbohydrate kinase
TREBR_RS00630	COG4154	Belongs to the RbsD FucU family
TREBR_RS00635	COG1879	ABC-type sugar transport system periplasmic component
TREBR_RS00645	COG4211	Belongs to the binding-protein-dependent transport system permease family
TREBR_RS00650	COG1609	Transcriptional regulator
TREBR_RS00655	COG0789	Transcriptional regulator
TREBR_RS00660	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TREBR_RS00680	COG3681	Belongs to the UPF0597 family
TREBR_RS00695	COG3708	Transcriptional regulator
TREBR_RS00695	COG2207	Transcriptional regulator
TREBR_RS00735	COG0534	Mate efflux family protein
TREBR_RS00750	COG1794	racemase activity, acting on amino acids and derivatives
TREBR_RS00785	COG5002	protein histidine kinase activity
TREBR_RS00795	COG0745	RESPONSE REGULATOR receiver
TREBR_RS00805	COG5002	protein histidine kinase activity
TREBR_RS00815	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TREBR_RS00820	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TREBR_RS00835	COG0573	inorganic phosphate transmembrane transporter activity
TREBR_RS00870	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TREBR_RS00915	COG1175	transmembrane transport
TREBR_RS00920	COG0395	ABC-type sugar transport system, permease component
TREBR_RS00935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TREBR_RS00940	COG1609	Transcriptional regulator
TREBR_RS00945	COG2201	protein-glutamate methylesterase activity
TREBR_RS00955	COG0004	ammonium transporteR
TREBR_RS00960	COG0583	DNA-binding transcription factor activity
TREBR_RS00990	COG0656	L-ascorbic acid biosynthetic process
TREBR_RS01000	COG1028	Short-chain dehydrogenase reductase Sdr
TREBR_RS01020	COG0667	Aldo Keto reductase
TREBR_RS01075	COG0612	Peptidase, M16
TREBR_RS01085	COG1132	(ABC) transporter
TREBR_RS01090	COG0488	(ABC) transporter
TREBR_RS01105	COG0840	transmembrane signaling receptor activity
TREBR_RS01120	COG1047	Peptidyl-prolyl cis-trans
TREBR_RS01135	COG5001	Diguanylate cyclase
TREBR_RS01145	COG1131	(ABC) transporter
TREBR_RS01155	COG1263	PTS System
TREBR_RS01155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TREBR_RS01165	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TREBR_RS01170	COG3711	transcriptional antiterminator
TREBR_RS01175	COG2723	6-phospho-beta-galactosidase activity
TREBR_RS01180	COG1263	PTS System
TREBR_RS01180	COG2190	(PTS) system
TREBR_RS01180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TREBR_RS01210	COG0505	Belongs to the CarA family
TREBR_RS01215	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TREBR_RS01230	COG0039	L-malate dehydrogenase activity
TREBR_RS01235	COG3706	GGDEF domain
TREBR_RS01240	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TREBR_RS01245	COG0671	phosphoesterase, PA-phosphatase related
TREBR_RS01255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TREBR_RS01270	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TREBR_RS01280	COG1971	Probably functions as a manganese efflux pump
TREBR_RS01285	COG1609	Transcriptional regulator
TREBR_RS01290	COG1869	D-ribose catabolic process
TREBR_RS01295	COG1129	ABC transporter
TREBR_RS01300	COG1172	Belongs to the binding-protein-dependent transport system permease family
TREBR_RS01305	COG1879	ABC-type sugar transport system periplasmic component
TREBR_RS01310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TREBR_RS01320	COG1704	LemA family
TREBR_RS01350	COG0442	prolyl-tRNA aminoacylation
TREBR_RS01370	COG0028	Belongs to the TPP enzyme family
TREBR_RS01370	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
TREBR_RS01390	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TREBR_RS01405	COG0562	UDP-galactopyranose mutase
TREBR_RS01415	COG1216	Glycosyl transferase, family 2
TREBR_RS01440	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TREBR_RS01445	COG0463	Glycosyl transferase, family 2
TREBR_RS01480	COG0706	membrane insertase activity
TREBR_RS01510	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TREBR_RS01525	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TREBR_RS01550	COG1285	pathogenesis
TREBR_RS01565	COG0561	phosphatase activity
TREBR_RS01575	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TREBR_RS01590	COG2972	Histidine kinase
TREBR_RS01600	COG1175	transmembrane transport
TREBR_RS01605	COG0395	ABC-type sugar transport system, permease component
TREBR_RS01615	COG0318	PFAM AMP-dependent synthetase and ligase
TREBR_RS01660	COG2900	Belongs to the SlyX family
TREBR_RS01665	COG1609	Transcriptional regulator
TREBR_RS01670	COG1129	ABC transporter
TREBR_RS01690	COG0745	RESPONSE REGULATOR receiver
TREBR_RS01695	COG0037	tRNA processing
TREBR_RS01700	COG1475	DNA binding
TREBR_RS01710	COG0668	transmembrane transport
TREBR_RS01715	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TREBR_RS01720	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TREBR_RS01740	COG0535	radical SAM domain protein
TREBR_RS01760	COG2189	Belongs to the N(4) N(6)-methyltransferase family
TREBR_RS01770	COG4120	Belongs to the binding-protein-dependent transport system permease family
TREBR_RS01800	COG1061	Type III restriction enzyme res subunit
TREBR_RS01845	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TREBR_RS01850	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TREBR_RS01855	COG1088	dTDP-glucose 4,6-dehydratase activity
TREBR_RS01875	COG1475	DNA binding
TREBR_RS01880	COG1192	Involved in chromosome partitioning
TREBR_RS01935	COG0753	catalase activity
TREBR_RS01940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TREBR_RS01950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TREBR_RS01955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TREBR_RS01970	COG2210	Belongs to the sulfur carrier protein TusA family
TREBR_RS01980	COG3706	GGDEF domain
TREBR_RS01990	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TREBR_RS02005	COG0004	ammonium transporteR
TREBR_RS02015	COG0151	Belongs to the GarS family
TREBR_RS02080	COG0534	Mate efflux family protein
TREBR_RS02085	COG0475	glutathione-regulated potassium exporter activity
TREBR_RS02090	COG0534	Mate efflux family protein
TREBR_RS02095	COG2848	UPF0210 protein
TREBR_RS02100	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TREBR_RS02115	COG1609	Transcriptional regulator
TREBR_RS02120	COG1653	transport
TREBR_RS02125	COG1175	transmembrane transport
TREBR_RS02130	COG0395	ABC-type sugar transport system, permease component
TREBR_RS02135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TREBR_RS02145	COG3833	ABC-type maltose transport systems, permease component
TREBR_RS02180	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TREBR_RS02200	COG1216	Glycosyl transferase, family 2
TREBR_RS02205	COG3754	Rhamnan synthesis protein F
TREBR_RS02225	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
TREBR_RS02230	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TREBR_RS02275	COG1609	Transcriptional regulator
TREBR_RS02280	COG0613	PHP domain protein
TREBR_RS02285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TREBR_RS02285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TREBR_RS02305	COG5278	phosphoserine phosphatase activity
TREBR_RS02305	COG0840	transmembrane signaling receptor activity
TREBR_RS02315	COG3437	response regulator, receiver
TREBR_RS02315	COG2770	Histidine kinase
TREBR_RS02320	COG3263	regulation of cellular component size
TREBR_RS02325	COG0488	(ABC) transporter
TREBR_RS02335	COG0583	DNA-binding transcription factor activity
TREBR_RS02340	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TREBR_RS02350	COG1609	Transcriptional regulator
TREBR_RS02355	COG4209	transmembrane transport
TREBR_RS02360	COG0395	ABC-type sugar transport system, permease component
TREBR_RS02365	COG1653	transport
TREBR_RS02375	COG1132	(ABC) transporter
TREBR_RS02385	COG1119	ATPase activity
TREBR_RS02390	COG1388	LysM domain
TREBR_RS02390	COG3858	chitin binding
TREBR_RS02405	COG0708	Exodeoxyribonuclease III
TREBR_RS02415	COG0148	phosphopyruvate hydratase activity
TREBR_RS02445	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TREBR_RS02460	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TREBR_RS02465	COG0205	6-phosphofructokinase activity
TREBR_RS02495	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TREBR_RS02525	COG0534	Mate efflux family protein
TREBR_RS02545	COG1516	flagellar protein fliS
TREBR_RS02550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TREBR_RS02555	COG0534	Mate efflux family protein
TREBR_RS02565	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TREBR_RS02595	COG0542	response to heat
TREBR_RS02615	COG1380	Effector of murein hydrolase LrgA
TREBR_RS02630	COG2873	o-acetylhomoserine
TREBR_RS02655	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TREBR_RS02670	COG1595	DNA-templated transcription, initiation
TREBR_RS02680	COG0210	DNA helicase
TREBR_RS02685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TREBR_RS02700	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
TREBR_RS02715	COG2197	response regulator
TREBR_RS02740	COG4214	carbohydrate transport
TREBR_RS02750	COG4213	ABC transporter substrate-binding protein
TREBR_RS02755	COG4213	ABC transporter substrate-binding protein
TREBR_RS02760	COG2207	Transcriptional regulator
TREBR_RS02760	COG4753	response regulator
TREBR_RS02760	COG2207	Transcriptional regulator
TREBR_RS02760	COG4753	response regulator
TREBR_RS02765	COG2972	Histidine kinase
TREBR_RS02775	COG3708	Transcriptional regulator
TREBR_RS02775	COG2207	Transcriptional regulator
TREBR_RS02790	COG4720	Psort location CytoplasmicMembrane, score
TREBR_RS02800	COG0138	bifunctional purine biosynthesis protein purh
TREBR_RS02815	COG0488	(ABC) transporter
TREBR_RS02825	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TREBR_RS02830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TREBR_RS02850	COG0826	peptidase U32
TREBR_RS02855	COG0629	single-stranded DNA binding
TREBR_RS02870	COG0517	IMP dehydrogenase activity
TREBR_RS02870	COG1227	inorganic diphosphatase activity
TREBR_RS02885	COG0564	pseudouridine synthase activity
TREBR_RS02890	COG0785	Cytochrome C biogenesis protein
TREBR_RS02905	COG1744	ABC transporter substrate-binding protein PnrA-like
TREBR_RS02910	COG3845	ABC transporter
TREBR_RS02915	COG4603	Belongs to the binding-protein-dependent transport system permease family
TREBR_RS02920	COG1079	Belongs to the binding-protein-dependent transport system permease family
TREBR_RS02930	COG0840	transmembrane signaling receptor activity
TREBR_RS02940	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
TREBR_RS02945	COG0513	Belongs to the DEAD box helicase family
TREBR_RS03015	COG1164	Oligoendopeptidase f
TREBR_RS03020	COG0514	ATP-dependent DNA helicase (RecQ)
TREBR_RS03025	COG2885	chlorophyll binding
TREBR_RS03040	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TREBR_RS03045	COG1177	transmembrane transport
TREBR_RS03050	COG1176	ABC-type spermidine putrescine transport system, permease component I
TREBR_RS03055	COG3842	ATPase activity
TREBR_RS03065	COG1687	branched-chain amino acid
TREBR_RS03070	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
TREBR_RS03075	COG0366	Alpha amylase catalytic
TREBR_RS03085	COG3956	TIGRFAM MazG family protein
TREBR_RS03090	COG0193	aminoacyl-tRNA hydrolase activity
TREBR_RS03095	COG0740	serine-type endopeptidase activity
TREBR_RS03105	COG0724	RNA recognition motif
TREBR_RS03115	COG1283	sodium-dependent phosphate transmembrane transporter activity
TREBR_RS03135	COG1126	abc transporter atp-binding protein
TREBR_RS03140	COG0765	amino acid transport
TREBR_RS03145	COG0525	valine-tRNA ligase activity
TREBR_RS03155	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TREBR_RS03170	COG5001	Diguanylate cyclase
TREBR_RS03170	COG4251	negative regulation of phosphorylation
TREBR_RS03170	COG2203	Gaf domain
TREBR_RS03170	COG3706	GGDEF domain
TREBR_RS03180	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TREBR_RS03195	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TREBR_RS03200	COG1469	GTP cyclohydrolase I activity
TREBR_RS03210	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TREBR_RS03230	COG2226	methyltransferase
TREBR_RS03235	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TREBR_RS03250	COG0745	RESPONSE REGULATOR receiver
TREBR_RS03265	COG2208	phosphoserine phosphatase activity
TREBR_RS03270	COG0616	signal peptide processing
TREBR_RS03285	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TREBR_RS03295	COG1917	Cupin 2, conserved barrel domain protein
TREBR_RS03295	COG2207	Transcriptional regulator
TREBR_RS03300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TREBR_RS03325	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TREBR_RS03330	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TREBR_RS03335	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TREBR_RS03345	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TREBR_RS03350	COG2610	gluconate transmembrane transporter activity
TREBR_RS03360	COG3395	kinase activity
TREBR_RS03365	COG1349	DNA-binding transcription factor activity
TREBR_RS03370	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TREBR_RS03380	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TREBR_RS03390	COG1725	Transcriptional regulator
TREBR_RS03395	COG1131	(ABC) transporter
TREBR_RS03405	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TREBR_RS03415	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TREBR_RS03435	COG0067	glutamate synthase
TREBR_RS03465	COG1074	ATP-dependent DNA helicase activity
TREBR_RS03490	COG0366	Alpha amylase catalytic
TREBR_RS03495	COG1523	belongs to the glycosyl hydrolase 13 family
TREBR_RS03500	COG2182	Extracellular solute-binding protein
TREBR_RS03505	COG1175	transmembrane transport
TREBR_RS03510	COG3833	ABC-type maltose transport systems, permease component
TREBR_RS03535	COG0367	asparagine synthase
TREBR_RS03540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TREBR_RS03545	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TREBR_RS03555	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TREBR_RS03560	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TREBR_RS03580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TREBR_RS03585	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TREBR_RS03590	COG0704	Plays a role in the regulation of phosphate uptake
TREBR_RS03610	COG0788	formyltetrahydrofolate deformylase activity
TREBR_RS03620	COG0426	domain, Protein
TREBR_RS03620	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TREBR_RS03630	COG3275	phosphorelay sensor kinase activity
TREBR_RS03635	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
TREBR_RS03640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TREBR_RS03655	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TREBR_RS03660	COG1418	mRNA catabolic process
TREBR_RS03670	COG2201	protein-glutamate methylesterase activity
TREBR_RS03685	COG0142	geranyltranstransferase activity
TREBR_RS03690	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TREBR_RS03695	COG1196	nuclear chromosome segregation
TREBR_RS03695	COG0741	lytic transglycosylase activity
TREBR_RS03695	COG0739	heme binding
TREBR_RS03700	COG1396	sequence-specific DNA binding
TREBR_RS03710	COG0028	Belongs to the TPP enzyme family
TREBR_RS03715	COG0563	adenylate kinase activity
TREBR_RS03725	COG2244	polysaccharide biosynthetic process
TREBR_RS03740	COG1181	Belongs to the D-alanine--D-alanine ligase family
TREBR_RS03755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TREBR_RS03810	COG0107	imidazoleglycerol-phosphate synthase activity
TREBR_RS03815	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TREBR_RS03830	COG0328	RNA-DNA hybrid ribonuclease activity
TREBR_RS03835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TREBR_RS03840	COG1686	Belongs to the peptidase S11 family
TREBR_RS03845	COG0129	dihydroxy-acid dehydratase activity
TREBR_RS03850	COG0028	Belongs to the TPP enzyme family
TREBR_RS03855	COG0436	Aminotransferase
TREBR_RS03870	COG2198	Histidine kinase
TREBR_RS03870	COG0643	Histidine kinase
TREBR_RS03875	COG0835	chemotaxis
TREBR_RS03885	COG2201	protein-glutamate methylesterase activity
TREBR_RS03900	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TREBR_RS03905	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
TREBR_RS03910	COG0037	tRNA processing
TREBR_RS03925	COG0012	GTP binding
TREBR_RS03980	COG0423	glycine-tRNA ligase activity
TREBR_RS03990	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TREBR_RS03995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TREBR_RS04005	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TREBR_RS04010	COG1028	Short-chain dehydrogenase reductase Sdr
TREBR_RS04015	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TREBR_RS04020	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TREBR_RS04025	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TREBR_RS04040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TREBR_RS04045	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TREBR_RS04050	COG0762	integral membrane protein
TREBR_RS04055	COG0587	DNA-directed DNA polymerase activity
TREBR_RS04060	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TREBR_RS04065	COG2011	ABC-type metal ion transport system permease component
TREBR_RS04070	COG1464	Belongs to the NlpA lipoprotein family
TREBR_RS04080	COG5002	protein histidine kinase activity
TREBR_RS04110	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TREBR_RS04125	COG0028	Belongs to the TPP enzyme family
TREBR_RS04130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TREBR_RS04140	COG1088	dTDP-glucose 4,6-dehydratase activity
TREBR_RS04165	COG3754	Rhamnan synthesis protein F
TREBR_RS04190	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TREBR_RS04215	COG1862	Preprotein translocase
TREBR_RS04220	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TREBR_RS04225	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TREBR_RS04230	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TREBR_RS04235	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TREBR_RS04245	COG0126	phosphoglycerate kinase activity
TREBR_RS04255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TREBR_RS04270	COG1028	Short-chain dehydrogenase reductase Sdr
TREBR_RS04275	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TREBR_RS04280	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TREBR_RS04290	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TREBR_RS04295	COG2207	Transcriptional regulator
TREBR_RS04305	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TREBR_RS04315	COG0493	'glutamate synthase
TREBR_RS04320	COG3070	regulator of competence-specific genes
TREBR_RS04345	COG2878	Part of a membrane complex involved in electron transport
TREBR_RS04345	COG1245	4Fe-4S binding domain
TREBR_RS04350	COG4657	Part of a membrane complex involved in electron transport
TREBR_RS04355	COG4660	Part of a membrane complex involved in electron transport
TREBR_RS04365	COG4658	electron transport chain
TREBR_RS04370	COG4656	Part of a membrane complex involved in electron transport
TREBR_RS04385	COG2200	EAL domain
TREBR_RS04385	COG3287	FIST C domain
TREBR_RS04385	COG2199	diguanylate cyclase activity
TREBR_RS04390	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TREBR_RS04395	COG0840	transmembrane signaling receptor activity
TREBR_RS04405	COG2885	chlorophyll binding
TREBR_RS04430	COG1773	rubredoxin
TREBR_RS04435	COG0577	efflux transmembrane transporter activity
TREBR_RS04435	COG1136	(ABC) transporter
TREBR_RS04440	COG1136	(ABC) transporter
TREBR_RS04445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TREBR_RS04455	COG0504	CTP synthase activity
TREBR_RS04470	COG1137	ATPase activity
TREBR_RS04475	COG2703	oxygen carrier activity
TREBR_RS04500	COG1739	Uncharacterized protein family UPF0029
TREBR_RS04510	COG0017	Asparaginyl-tRNA synthetase
TREBR_RS04525	COG1720	tRNA m6t6A37 methyltransferase activity
TREBR_RS04535	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TREBR_RS04570	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
TREBR_RS04575	COG0018	arginyl-trna synthetase
TREBR_RS04585	COG5278	phosphoserine phosphatase activity
TREBR_RS04585	COG0840	transmembrane signaling receptor activity
TREBR_RS04595	COG0228	four-way junction DNA binding
TREBR_RS04600	COG1837	Belongs to the UPF0109 family
TREBR_RS04605	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TREBR_RS04610	COG0336	Belongs to the RNA methyltransferase TrmD family
TREBR_RS04615	COG0335	large ribosomal subunit rRNA binding
TREBR_RS04635	COG0792	nuclease activity
TREBR_RS04675	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TREBR_RS04705	COG0577	efflux transmembrane transporter activity
TREBR_RS04705	COG1136	(ABC) transporter
TREBR_RS04725	COG1136	(ABC) transporter
TREBR_RS04740	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TREBR_RS04775	COG2770	Histidine kinase
TREBR_RS04775	COG3437	response regulator, receiver
TREBR_RS04780	COG1671	Belongs to the UPF0178 family
TREBR_RS04785	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
TREBR_RS04795	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TREBR_RS04800	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TREBR_RS04815	COG0191	fructose-bisphosphate aldolase activity
TREBR_RS04835	COG2001	Belongs to the MraZ family
TREBR_RS04840	COG0275	rRNA processing
TREBR_RS04850	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TREBR_RS04855	COG0772	Belongs to the SEDS family
TREBR_RS04860	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TREBR_RS04890	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TREBR_RS04890	COG0551	DNA topoisomerase type I activity
TREBR_RS04895	COG4974	Belongs to the 'phage' integrase family
TREBR_RS04900	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TREBR_RS04905	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TREBR_RS04910	COG1815	bacterial-type flagellum-dependent cell motility
TREBR_RS04925	COG1766	The M ring may be actively involved in energy transduction
TREBR_RS04935	COG1317	bacterial-type flagellum organization
TREBR_RS04940	COG1157	protein secretion by the type III secretion system
TREBR_RS04950	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TREBR_RS04960	COG0301	tRNA thio-modification
TREBR_RS04965	COG1022	Amp-dependent synthetase and ligase
TREBR_RS04990	COG2095	MarC family integral membrane protein
TREBR_RS05000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TREBR_RS05005	COG0765	amino acid transport
TREBR_RS05010	COG1126	abc transporter atp-binding protein
TREBR_RS05020	COG1480	7TM receptor with intracellular HD hydrolase
TREBR_RS05025	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TREBR_RS05055	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TREBR_RS05065	COG0552	protein localization to endoplasmic reticulum
TREBR_RS05075	COG4591	ABC-type transport system involved in lipoprotein release permease component
TREBR_RS05080	COG1136	(ABC) transporter
TREBR_RS05095	COG3869	Catalyzes the specific phosphorylation of arginine residues in
TREBR_RS05125	COG2205	protein histidine kinase activity
TREBR_RS05135	COG1592	Rubrerythrin
TREBR_RS05155	COG1309	transcriptional regulator
TREBR_RS05165	COG1683	Conserved Protein
TREBR_RS05180	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TREBR_RS05235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TREBR_RS05255	COG0330	HflC and HflK could
TREBR_RS05260	COG0330	HflC and HflK could
TREBR_RS05265	COG1309	transcriptional regulator
TREBR_RS05270	COG1132	(ABC) transporter
TREBR_RS05270	COG2375	cellular response to nickel ion
TREBR_RS05275	COG1132	(ABC) transporter
TREBR_RS05285	COG0789	Transcriptional regulator
TREBR_RS05315	COG0596	Alpha beta hydrolase
TREBR_RS05340	COG0693	protein deglycase activity
TREBR_RS05345	COG2378	regulation of single-species biofilm formation
TREBR_RS05355	COG1373	ATPase (AAA superfamily
TREBR_RS05365	COG2226	methyltransferase
TREBR_RS05400	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TREBR_RS05405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TREBR_RS05425	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TREBR_RS05510	COG0504	CTP synthase activity
TREBR_RS05520	COG0105	UTP biosynthetic process
TREBR_RS05525	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TREBR_RS05530	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TREBR_RS05535	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TREBR_RS05540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TREBR_RS05545	COG1609	Transcriptional regulator
TREBR_RS05550	COG1879	ABC-type sugar transport system periplasmic component
TREBR_RS05555	COG1129	ABC transporter
TREBR_RS05560	COG4211	Belongs to the binding-protein-dependent transport system permease family
TREBR_RS05565	COG0800	Aldolase
TREBR_RS05570	COG0640	Transcriptional regulator
TREBR_RS05575	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TREBR_RS05575	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TREBR_RS05580	COG1381	Involved in DNA repair and RecF pathway recombination
TREBR_RS05585	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TREBR_RS05590	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TREBR_RS05605	COG0084	hydrolase, TatD family'
TREBR_RS05615	COG0681	Belongs to the peptidase S26 family
TREBR_RS05625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TREBR_RS05640	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TREBR_RS05645	COG0154	amidase activity
TREBR_RS05650	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TREBR_RS05690	COG1070	Carbohydrate kinase
TREBR_RS05700	COG0205	6-phosphofructokinase activity
TREBR_RS05715	COG0556	nucleotide-excision repair
TREBR_RS05720	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TREBR_RS05725	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TREBR_RS05725	COG0321	lipoyl(octanoyl) transferase activity
TREBR_RS05765	COG0456	acetyltransferase
TREBR_RS05815	COG0823	Involved in the tonB-independent uptake of proteins
TREBR_RS05825	COG1987	bacterial-type flagellum assembly
TREBR_RS05830	COG1684	flagellar biosynthetic protein fliR
TREBR_RS05835	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TREBR_RS05840	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TREBR_RS05860	COG1191	sigma factor activity
TREBR_RS05895	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TREBR_RS05910	COG3852	Histidine kinase
TREBR_RS05915	COG2204	response regulator
TREBR_RS05920	COG1846	Transcriptional regulator
TREBR_RS05940	COG1078	dGTPase activity
TREBR_RS05945	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TREBR_RS05955	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TREBR_RS05965	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TREBR_RS05970	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TREBR_RS05980	COG0736	holo-[acyl-carrier-protein] synthase activity
TREBR_RS05990	COG0101	tRNA pseudouridine synthase activity
TREBR_RS05995	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TREBR_RS06000	COG1573	uracil-dna glycosylase
TREBR_RS06015	COG2033	superoxide reductase activity
TREBR_RS06025	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TREBR_RS06030	COG2968	Membrane
TREBR_RS06060	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TREBR_RS06070	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TREBR_RS06075	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TREBR_RS06080	COG1394	ATPase activity, coupled to movement of substances
TREBR_RS06085	COG1269	ATP hydrolysis coupled proton transport
TREBR_RS06095	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TREBR_RS06130	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TREBR_RS06140	COG1122	ATPase activity
TREBR_RS06145	COG1268	BioY protein
TREBR_RS06150	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TREBR_RS06155	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TREBR_RS06160	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TREBR_RS06175	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TREBR_RS06195	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TREBR_RS06200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TREBR_RS06210	COG0739	heme binding
TREBR_RS06260	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
TREBR_RS06275	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TREBR_RS06280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TREBR_RS06285	COG1120	ATPase activity
TREBR_RS06290	COG2207	Transcriptional regulator
TREBR_RS06290	COG4753	response regulator
TREBR_RS06295	COG2972	Histidine kinase
TREBR_RS06300	COG1129	ABC transporter
TREBR_RS06305	COG1129	ABC transporter
TREBR_RS06310	COG1172	Belongs to the binding-protein-dependent transport system permease family
TREBR_RS06365	COG0583	DNA-binding transcription factor activity
TREBR_RS06370	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TREBR_RS06375	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TREBR_RS06390	COG0803	Belongs to the bacterial solute-binding protein 9 family
TREBR_RS06400	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TREBR_RS06410	COG0756	dUTP diphosphatase activity
TREBR_RS06425	COG0343	queuine tRNA-ribosyltransferase activity
TREBR_RS06435	COG0835	chemotaxis
TREBR_RS06445	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TREBR_RS06450	COG0497	DNA recombination
TREBR_RS06460	COG1744	ABC transporter substrate-binding protein PnrA-like
TREBR_RS06465	COG3845	ABC transporter
TREBR_RS06470	COG4603	Belongs to the binding-protein-dependent transport system permease family
TREBR_RS06475	COG1079	Belongs to the binding-protein-dependent transport system permease family
TREBR_RS06480	COG3842	ATPase activity
TREBR_RS06485	COG0557	exoribonuclease II activity
TREBR_RS06490	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TREBR_RS06515	COG1459	type II secretion system
TREBR_RS06545	COG0534	Mate efflux family protein
TREBR_RS06550	COG1846	Transcriptional regulator
TREBR_RS06550	COG1940	carbohydrate kinase activity
TREBR_RS06555	COG1509	lysine 2,3-aminomutase activity
TREBR_RS06560	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TREBR_RS06565	COG0137	argininosuccinate synthase activity
TREBR_RS06575	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TREBR_RS06585	COG2814	Major facilitator Superfamily
TREBR_RS06590	COG1811	Na channel or pump
TREBR_RS06600	COG0513	Belongs to the DEAD box helicase family
TREBR_RS06605	COG0488	(ABC) transporter
TREBR_RS06620	COG1234	tRNA 3'-trailer cleavage
TREBR_RS06625	COG4555	ABC transporter
TREBR_RS06665	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TREBR_RS06670	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TREBR_RS06690	COG1840	ABC-type Fe3 transport system, periplasmic component
TREBR_RS06705	COG0285	dihydrofolate synthase activity
TREBR_RS06710	COG0653	protein targeting
TREBR_RS06730	COG0494	nUDIX hydrolase
TREBR_RS06750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TREBR_RS06755	COG1459	type II secretion system
TREBR_RS06870	COG0124	histidyl-tRNA synthetase
TREBR_RS06875	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TREBR_RS06885	COG2252	PERMEase
TREBR_RS06895	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TREBR_RS06905	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TREBR_RS06945	COG1011	Hydrolase
TREBR_RS06950	COG0772	Belongs to the SEDS family
TREBR_RS06955	COG0768	penicillin binding
TREBR_RS06970	COG1077	Cell shape determining protein MreB Mrl
TREBR_RS06985	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TREBR_RS06990	COG0358	DNA primase activity
TREBR_RS07025	COG0297	glycogen (starch) synthase activity
TREBR_RS07050	COG0617	tRNA 3'-terminal CCA addition
TREBR_RS07055	COG0180	Tryptophanyl-tRNA synthetase
TREBR_RS07065	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TREBR_RS07065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TREBR_RS07125	COG0617	tRNA 3'-terminal CCA addition
TREBR_RS07135	COG0116	Belongs to the methyltransferase superfamily
TREBR_RS07135	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TREBR_RS07150	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TREBR_RS07160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TREBR_RS07175	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TREBR_RS07185	COG3620	sequence-specific DNA binding
TREBR_RS07190	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TREBR_RS07190	COG0574	Belongs to the PEP-utilizing enzyme family
TREBR_RS07205	COG0569	domain protein
TREBR_RS07210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TREBR_RS07215	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TREBR_RS07225	COG1028	Short-chain dehydrogenase reductase Sdr
TREBR_RS07250	COG0571	ribonuclease III activity
TREBR_RS07255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TREBR_RS07260	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TREBR_RS07270	COG1413	lyase activity
TREBR_RS07280	COG0424	maF-like protein
TREBR_RS07285	COG0052	Belongs to the universal ribosomal protein uS2 family
TREBR_RS07290	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TREBR_RS07295	COG0233	cytoplasmic translational termination
TREBR_RS07300	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TREBR_RS07305	COG0575	Belongs to the CDS family
TREBR_RS07310	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TREBR_RS07315	COG0750	zinc metalloprotease
TREBR_RS07325	COG0305	Participates in initiation and elongation during chromosome replication
TREBR_RS07330	COG0359	binds to the 23S rRNA
TREBR_RS07335	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TREBR_RS07340	COG0629	single-stranded DNA binding
TREBR_RS07345	COG0360	Binds together with S18 to 16S ribosomal RNA
TREBR_RS07355	COG0495	leucyl-tRNA aminoacylation
TREBR_RS07360	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TREBR_RS07400	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TREBR_RS07410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TREBR_RS07420	COG1175	transmembrane transport
TREBR_RS07440	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TREBR_RS07450	COG1132	(ABC) transporter
TREBR_RS07500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TREBR_RS07505	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TREBR_RS07510	COG0215	cysteine-tRNA ligase activity
TREBR_RS07530	COG0528	UMP kinase activity
TREBR_RS07540	COG2003	Belongs to the UPF0758 family
TREBR_RS07550	COG0667	Aldo Keto reductase
TREBR_RS07555	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
TREBR_RS07560	COG0542	response to heat
TREBR_RS07580	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TREBR_RS07610	COG0632	four-way junction helicase activity
TREBR_RS07615	COG2255	four-way junction helicase activity
TREBR_RS07620	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TREBR_RS07625	COG1592	Rubrerythrin
TREBR_RS07625	COG1773	rubredoxin
TREBR_RS07650	COG0084	hydrolase, TatD family'
TREBR_RS07680	COG0643	Histidine kinase
TREBR_RS07680	COG2198	Histidine kinase
TREBR_RS07680	COG0643	Histidine kinase
TREBR_RS07680	COG0784	Response regulator, receiver
TREBR_RS07680	COG2198	Histidine kinase
TREBR_RS07680	COG0784	Response regulator, receiver
TREBR_RS07705	COG0484	heat shock protein binding
TREBR_RS07710	COG0443	Heat shock 70 kDa protein
TREBR_RS07715	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TREBR_RS07725	COG2502	aspartate--ammonia ligase
TREBR_RS07740	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TREBR_RS07770	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
TREBR_RS07775	COG0297	glycogen (starch) synthase activity
TREBR_RS07780	COG0436	Aminotransferase
TREBR_RS07790	COG0662	Cupin 2, conserved barrel domain protein
TREBR_RS07790	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
TREBR_RS07795	COG2089	acid synthase
TREBR_RS07800	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TREBR_RS07810	COG0009	L-threonylcarbamoyladenylate synthase
TREBR_RS07850	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TREBR_RS07860	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TREBR_RS07870	COG1102	Psort location Cytoplasmic, score
TREBR_RS07875	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TREBR_RS07890	COG1716	ATPase activity
TREBR_RS07890	COG0842	Transport permease protein
TREBR_RS07890	COG1131	(ABC) transporter
TREBR_RS07895	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TREBR_RS07900	COG0217	transcriptional regulatory protein
TREBR_RS07910	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TREBR_RS07935	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TREBR_RS07955	COG1334	flagellar protein FlaG
TREBR_RS07975	COG0802	atpase or kinase
TREBR_RS07985	COG5492	domain, Protein
TREBR_RS08005	COG5492	domain, Protein
TREBR_RS08015	COG0395	ABC-type sugar transport system, permease component
TREBR_RS08020	COG4209	transmembrane transport
TREBR_RS08035	COG1028	Short-chain dehydrogenase reductase Sdr
TREBR_RS08040	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TREBR_RS08055	COG2207	Transcriptional regulator
TREBR_RS08070	COG1196	nuclear chromosome segregation
TREBR_RS08115	COG0544	peptidyl-prolyl cis-trans isomerase activity
TREBR_RS08120	COG0740	serine-type endopeptidase activity
TREBR_RS08125	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TREBR_RS08145	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TREBR_RS08155	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TREBR_RS08160	COG2911	Protein conserved in bacteria
TREBR_RS08165	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TREBR_RS08175	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TREBR_RS08180	COG1104	cysteine desulfurase activity
TREBR_RS08200	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TREBR_RS08205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TREBR_RS08215	COG3942	CHAP domain
TREBR_RS08215	COG1388	LysM domain
TREBR_RS08225	COG1338	Plays a role in the flagellum-specific transport system
TREBR_RS08240	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TREBR_RS08245	COG1580	Controls the rotational direction of flagella during chemotaxis
TREBR_RS08250	COG1360	Flagellar Motor Protein
TREBR_RS08255	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TREBR_RS08270	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TREBR_RS08280	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TREBR_RS08300	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TREBR_RS08320	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TREBR_RS08340	COG0745	RESPONSE REGULATOR receiver
TREBR_RS08355	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TREBR_RS08355	COG0512	Glutamine amidotransferase of anthranilate synthase
TREBR_RS08360	COG0134	indole-3-glycerol-phosphate synthase activity
TREBR_RS08365	COG0133	tryptophan synthase activity
TREBR_RS08370	COG0159	tryptophan synthase activity
TREBR_RS08375	COG3525	Glycosyl hydrolase, family 20, catalytic domain
TREBR_RS08390	COG0519	Catalyzes the synthesis of GMP from XMP
TREBR_RS08395	COG1086	Polysaccharide biosynthesis protein
TREBR_RS08400	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TREBR_RS08420	COG0698	ribose 5-phosphate isomerase
TREBR_RS08430	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TREBR_RS08450	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
TREBR_RS08490	COG0438	transferase activity, transferring glycosyl groups
TREBR_RS08495	COG1216	Glycosyl transferase, family 2
TREBR_RS08545	COG1162	GTPase activity
TREBR_RS08550	COG1193	negative regulation of DNA recombination
TREBR_RS08555	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TREBR_RS08555	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TREBR_RS08555	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TREBR_RS08560	COG0295	cytidine deaminase activity
TREBR_RS08580	COG1104	cysteine desulfurase activity
TREBR_RS08595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TREBR_RS08600	COG2843	Capsule synthesis protein
TREBR_RS08605	COG1283	sodium-dependent phosphate transmembrane transporter activity
TREBR_RS08610	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TREBR_RS08615	COG4585	Histidine kinase
TREBR_RS08620	COG2197	response regulator
TREBR_RS08645	COG3842	ATPase activity
TREBR_RS08655	COG4143	(ABC) transporter
TREBR_RS08690	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TREBR_RS08695	COG0527	aspartate kinase activity
TREBR_RS08700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TREBR_RS08705	COG0024	Methionine aminopeptidase
TREBR_RS08710	COG0484	heat shock protein binding
TREBR_RS08725	COG1394	ATPase activity, coupled to movement of substances
TREBR_RS08730	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TREBR_RS08735	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TREBR_RS08755	COG1269	ATP hydrolysis coupled proton transport
TREBR_RS08770	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TREBR_RS08775	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TREBR_RS08780	COG0149	triose-phosphate isomerase activity
TREBR_RS08800	COG1187	pseudouridine synthase activity
TREBR_RS08805	COG1414	Transcriptional regulator
TREBR_RS08810	COG0372	Belongs to the citrate synthase family
TREBR_RS08815	COG0564	pseudouridine synthase activity
TREBR_RS08825	COG0724	RNA recognition motif
TREBR_RS08830	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TREBR_RS08845	COG2204	response regulator
TREBR_RS08850	COG0539	negative regulation of cytoplasmic translation
TREBR_RS08855	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TREBR_RS08865	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TREBR_RS08870	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TREBR_RS08880	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TREBR_RS08900	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TREBR_RS08910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TREBR_RS08910	COG1747	RNA polymerase binding
TREBR_RS08915	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TREBR_RS08920	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TREBR_RS08925	COG1475	DNA binding
TREBR_RS08990	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TREBR_RS09005	COG0280	phosphate acetyltransferase
TREBR_RS09025	COG0739	heme binding
TREBR_RS09050	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TREBR_RS09055	COG1086	Polysaccharide biosynthesis protein
TREBR_RS09075	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TREBR_RS09085	COG0534	Mate efflux family protein
TREBR_RS09100	COG0481	GTPase activity
TREBR_RS09105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TREBR_RS09140	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TREBR_RS09160	COG1713	HD superfamily hydrolase involved in NAD metabolism
TREBR_RS09170	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TREBR_RS09175	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TREBR_RS09185	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TREBR_RS09240	COG1132	(ABC) transporter
TREBR_RS09245	COG1132	(ABC) transporter
TREBR_RS09250	COG2378	regulation of single-species biofilm formation
TREBR_RS09270	COG0840	transmembrane signaling receptor activity
TREBR_RS09340	COG0438	transferase activity, transferring glycosyl groups
TREBR_RS09375	COG1438	arginine binding
TREBR_RS09400	COG0166	Belongs to the GPI family
TREBR_RS09425	COG0420	3'-5' exonuclease activity
TREBR_RS09430	COG0419	ATPase involved in DNA repair
TREBR_RS09445	COG0517	IMP dehydrogenase activity
TREBR_RS09445	COG0516	GMP reductase activity
TREBR_RS09450	COG0564	pseudouridine synthase activity
TREBR_RS09455	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TREBR_RS09470	COG1199	ATP-dependent helicase activity
TREBR_RS09495	COG0860	N-Acetylmuramoyl-L-alanine amidase
TREBR_RS09495	COG2247	cell wall binding repeat
TREBR_RS09500	COG0151	Belongs to the GarS family
TREBR_RS09505	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TREBR_RS09520	COG0366	Alpha amylase catalytic
TREBR_RS09530	COG1722	exodeoxyribonuclease VII activity
TREBR_RS09535	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TREBR_RS09570	COG1366	Belongs to the anti-sigma-factor antagonist family
TREBR_RS09585	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
TREBR_RS09590	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TREBR_RS09605	COG2217	Heavy metal translocating P-type atpase
TREBR_RS09610	COG1937	Protein conserved in bacteria
TREBR_RS09620	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TREBR_RS09690	COG0463	Glycosyl transferase, family 2
TREBR_RS09720	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TREBR_RS09725	COG1181	Belongs to the D-alanine--D-alanine ligase family
TREBR_RS09730	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TREBR_RS09740	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TREBR_RS09745	COG4786	Flagellar basal body rod
TREBR_RS09760	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TREBR_RS09765	COG1482	cell wall glycoprotein biosynthetic process
TREBR_RS09780	COG0813	purine-nucleoside phosphorylase activity
TREBR_RS09800	COG2059	Chromate
TREBR_RS09805	COG0534	Mate efflux family protein
TREBR_RS09810	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TREBR_RS09820	COG1116	anion transmembrane transporter activity
TREBR_RS09835	COG3977	Valine--pyruvate aminotransferase
TREBR_RS09850	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TREBR_RS09860	COG0268	Binds directly to 16S ribosomal RNA
TREBR_RS09865	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TREBR_RS09865	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TREBR_RS09875	COG1472	Belongs to the glycosyl hydrolase 3 family
TREBR_RS09885	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TREBR_RS09895	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
TREBR_RS09900	COG2942	2-epimerase
TREBR_RS09905	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
TREBR_RS09925	COG1175	transmembrane transport
TREBR_RS09950	COG1609	Transcriptional regulator
TREBR_RS09980	COG4452	Inner membrane protein CreD
TREBR_RS10000	COG0768	penicillin binding
TREBR_RS10010	COG0739	heme binding
TREBR_RS10025	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TREBR_RS10045	COG4166	transmembrane transport
TREBR_RS10050	COG1329	Transcriptional regulator
TREBR_RS10055	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TREBR_RS10055	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TREBR_RS10075	COG0848	biopolymer transport protein
TREBR_RS10080	COG0811	peptide transport
TREBR_RS10120	COG0728	peptidoglycan biosynthetic process
TREBR_RS10125	COG0006	proline dipeptidase activity
TREBR_RS10140	COG0322	excinuclease ABC activity
TREBR_RS10145	COG0612	Peptidase, M16
TREBR_RS10150	COG1185	polyribonucleotide nucleotidyltransferase activity
TREBR_RS10155	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TREBR_RS10165	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TREBR_RS10170	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TREBR_RS10175	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TREBR_RS10185	COG0779	Required for maturation of 30S ribosomal subunits
TREBR_RS10250	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TREBR_RS10270	COG0813	purine-nucleoside phosphorylase activity
TREBR_RS10275	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TREBR_RS10320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TREBR_RS10375	COG0659	secondary active sulfate transmembrane transporter activity
TREBR_RS10395	COG2050	protein possibly involved in aromatic compounds catabolism
TREBR_RS10405	COG0395	ABC-type sugar transport system, permease component
TREBR_RS10410	COG1175	transmembrane transport
TREBR_RS10430	COG0363	glucosamine-6-phosphate deaminase activity
TREBR_RS10435	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TREBR_RS10440	COG3459	Glycosyltransferase 36 associated
TREBR_RS10460	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TREBR_RS10490	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
TREBR_RS10505	COG0114	fumarate hydratase activity
TREBR_RS10520	COG0640	Transcriptional regulator
TREBR_RS10530	COG2233	PERMEase
TREBR_RS10540	COG0840	transmembrane signaling receptor activity
TREBR_RS10545	COG0473	3-isopropylmalate dehydrogenase activity
TREBR_RS10585	COG1442	glycosyl transferase family 8
TREBR_RS10585	COG1216	Glycosyl transferase, family 2
TREBR_RS10630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TREBR_RS10635	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TREBR_RS10645	COG1172	Belongs to the binding-protein-dependent transport system permease family
TREBR_RS10650	COG1129	ABC transporter
TREBR_RS10655	COG2942	2-epimerase
TREBR_RS10670	COG2217	Heavy metal translocating P-type atpase
TREBR_RS10685	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TREBR_RS10700	COG0237	dephospho-CoA kinase activity
TREBR_RS10705	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TREBR_RS10705	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TREBR_RS10705	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TREBR_RS10745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TREBR_RS10760	COG5002	protein histidine kinase activity
TREBR_RS10760	COG2205	protein histidine kinase activity
TREBR_RS10760	COG0784	Response regulator, receiver
TREBR_RS10775	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TREBR_RS10780	COG0484	heat shock protein binding
TREBR_RS10815	COG0714	Associated with various cellular activities
TREBR_RS10850	COG0254	rRNA binding
TREBR_RS10855	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TREBR_RS10870	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
TREBR_RS10875	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
TREBR_RS10885	COG0826	peptidase U32
TREBR_RS10890	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TREBR_RS10895	COG2890	protein-(glutamine-N5) methyltransferase activity
TREBR_RS10900	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TREBR_RS10910	COG4716	Myosin-crossreactive antigen
TREBR_RS10955	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TREBR_RS10970	COG0494	nUDIX hydrolase
TREBR_RS10985	COG4443	Transcriptional Coactivator p15 (PC4)
TREBR_RS11000	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TREBR_RS11025	COG4536	flavin adenine dinucleotide binding
TREBR_RS11030	COG4536	flavin adenine dinucleotide binding
TREBR_RS11040	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TREBR_RS11045	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TREBR_RS11060	COG1522	sequence-specific DNA binding
TREBR_RS11065	COG0436	Aminotransferase
TREBR_RS11075	COG1122	ATPase activity
TREBR_RS11085	COG0530	calcium, potassium:sodium antiporter activity
TREBR_RS11095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TREBR_RS11100	COG1136	(ABC) transporter
TREBR_RS11105	COG0577	efflux transmembrane transporter activity
TREBR_RS11110	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TREBR_RS11115	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TREBR_RS11120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TREBR_RS11125	COG3118	belongs to the thioredoxin family
TREBR_RS11155	COG0534	Mate efflux family protein
TREBR_RS11170	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TREBR_RS11180	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TREBR_RS11195	COG1131	(ABC) transporter
TREBR_RS11220	COG1518	maintenance of DNA repeat elements
TREBR_RS11250	COG3328	transposase activity
TREBR_RS11290	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TREBR_RS11295	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TREBR_RS11315	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TREBR_RS11325	COG1757	Na H antiporter
TREBR_RS11340	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TREBR_RS11350	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TREBR_RS11360	COG0058	SHG alpha-glucan phosphorylase activity
TREBR_RS11370	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TREBR_RS11390	COG0492	ferredoxin-NADP+ reductase activity
TREBR_RS11425	COG0701	Predicted permease
TREBR_RS11435	COG0596	Alpha beta hydrolase
TREBR_RS11450	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TREBR_RS11455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TREBR_RS11470	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TREBR_RS11470	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TREBR_RS11470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TREBR_RS11500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TREBR_RS11510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TREBR_RS11560	COG1640	4-alpha-glucanotransferase
TREBR_RS11570	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TREBR_RS11590	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TREBR_RS11615	COG1028	Short-chain dehydrogenase reductase Sdr
TREBR_RS11620	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TREBR_RS11635	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TREBR_RS11640	COG0793	Belongs to the peptidase S41A family
TREBR_RS11650	COG0455	bacterial-type flagellum organization
TREBR_RS11655	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TREBR_RS11660	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TREBR_RS11680	COG0516	GMP reductase activity
TREBR_RS11680	COG0517	IMP dehydrogenase activity
TREBR_RS11710	COG0203	ribosomal protein L17
TREBR_RS11715	COG0202	RNA polymerase activity
TREBR_RS11720	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TREBR_RS11725	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TREBR_RS11740	COG0200	Binds to the 23S rRNA
TREBR_RS11745	COG1841	ribosomal large subunit assembly
TREBR_RS11750	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TREBR_RS11755	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TREBR_RS11760	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TREBR_RS11765	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TREBR_RS11770	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TREBR_RS11775	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TREBR_RS11785	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TREBR_RS11790	COG0255	Belongs to the universal ribosomal protein uL29 family
TREBR_RS11800	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TREBR_RS11805	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TREBR_RS11815	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TREBR_RS11820	COG0089	rRNA binding
TREBR_RS11825	COG0088	Forms part of the polypeptide exit tunnel
TREBR_RS11830	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TREBR_RS11835	COG0051	transcription antitermination factor activity, RNA binding
TREBR_RS11840	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TREBR_RS11845	COG0049	tRNA binding
TREBR_RS11860	COG0085	RNA polymerase activity
TREBR_RS11865	COG0222	ribosome binding
TREBR_RS11875	COG0081	regulation of translation
TREBR_RS11880	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TREBR_RS11885	COG0250	Participates in transcription elongation, termination and antitermination
TREBR_RS11890	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TREBR_RS11900	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TREBR_RS11910	COG1045	serine acetyltransferase
TREBR_RS11940	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TREBR_RS11945	COG1674	ftsk spoiiie
TREBR_RS11970	COG1472	Belongs to the glycosyl hydrolase 3 family
TREBR_RS11980	COG0450	alkyl hydroperoxide reductase
TREBR_RS11995	COG0543	2 iron, 2 sulfur cluster binding
TREBR_RS12000	COG0493	'glutamate synthase
TREBR_RS12010	COG1022	Amp-dependent synthetase and ligase
TREBR_RS12035	COG3706	GGDEF domain
TREBR_RS12035	COG4251	negative regulation of phosphorylation
TREBR_RS12035	COG2203	Gaf domain
TREBR_RS12035	COG5001	Diguanylate cyclase
TREBR_RS12075	COG3116	cell division
TREBR_RS12075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TREBR_RS12080	COG0084	hydrolase, TatD family'
TREBR_RS12085	COG0739	heme binding
TREBR_RS12100	COG1774	PSP1 C-terminal conserved region
TREBR_RS12115	COG0534	Mate efflux family protein
TREBR_RS12135	COG1175	transmembrane transport
TREBR_RS12140	COG0395	ABC-type sugar transport system, permease component
TREBR_RS12145	COG5426	von Willebrand factor, type A
TREBR_RS12150	COG0641	radical SAM
TREBR_RS12155	COG3119	arylsulfatase activity
TREBR_RS12185	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TREBR_RS12185	COG0140	phosphoribosyl-ATP diphosphatase activity
TREBR_RS12190	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TREBR_RS12200	COG0628	permease
TREBR_RS12215	COG1854	S-ribosylhomocysteine lyase activity
TREBR_RS12220	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TREBR_RS12225	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
TREBR_RS12230	COG0494	nUDIX hydrolase
TREBR_RS12235	COG0674	pyruvate-flavodoxin oxidoreductase activity
TREBR_RS12235	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TREBR_RS12235	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TREBR_RS12235	COG1013	pyruvate-flavodoxin oxidoreductase activity
TREBR_RS12245	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TREBR_RS12260	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TREBR_RS12280	COG0357	Ribosomal RNA small subunit methyltransferase G
TREBR_RS12300	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TREBR_RS12305	COG0501	Belongs to the peptidase M48B family
TREBR_RS12315	COG0475	glutathione-regulated potassium exporter activity
TREBR_RS12330	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TREBR_RS12335	COG1609	Transcriptional regulator
TREBR_RS12340	COG3870	Protein conserved in bacteria
TREBR_RS12380	COG2183	response to ionizing radiation
TREBR_RS12430	COG1012	belongs to the aldehyde dehydrogenase family
TREBR_RS12445	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TREBR_RS12450	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TREBR_RS12455	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TREBR_RS12465	COG1643	Atp-dependent helicase
TREBR_RS12470	COG0840	transmembrane signaling receptor activity
TREBR_RS12475	COG1272	protein, Hemolysin III
TREBR_RS12480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TREBR_RS12485	COG3012	SEC-C Motif Domain Protein
TREBR_RS12510	COG1252	NADH dehydrogenase
TREBR_RS12515	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TREBR_RS12525	COG0326	Molecular chaperone. Has ATPase activity
TREBR_RS12545	COG0737	Belongs to the 5'-nucleotidase family
TREBR_RS12555	COG0116	Belongs to the methyltransferase superfamily
TREBR_RS12580	COG0732	type I restriction modification DNA specificity domain
TREBR_RS12660	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TREBR_RS12695	COG4206	TonB-dependent receptor
TREBR_RS12700	COG0646	methionine synthase
TREBR_RS12700	COG1410	methionine synthase
TREBR_RS12715	COG0463	Glycosyl transferase, family 2
TREBR_RS12735	COG2832	Protein of unknown function (DUF454)
TREBR_RS12745	COG1131	(ABC) transporter
TREBR_RS12755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TREBR_RS12760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TREBR_RS12765	COG1120	ATPase activity
TREBR_RS12785	COG4753	response regulator
TREBR_RS12785	COG2207	Transcriptional regulator
TREBR_RS12790	COG2972	Histidine kinase
TREBR_RS12800	COG0395	ABC-type sugar transport system, permease component
TREBR_RS12805	COG4209	transmembrane transport
TREBR_RS12815	COG5520	Belongs to the glycosyl hydrolase 30 family
TREBR_RS12835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TREBR_RS12850	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TREBR_RS12855	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TREBR_RS12865	COG1639	'signal transduction protein
TREBR_RS12885	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TREBR_RS12920	COG4953	penicillin-binding protein 1C
TREBR_RS12930	COG1968	undecaprenyl-diphosphatase activity
TREBR_RS12940	COG1151	hydroxylamine reductase activity
TREBR_RS12965	COG0205	6-phosphofructokinase activity
TREBR_RS12985	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TREBR_RS12995	COG2738	Putative neutral zinc metallopeptidase
TREBR_RS13005	COG1175	transmembrane transport
TREBR_RS13010	COG0395	ABC-type sugar transport system, permease component
TREBR_RS13015	COG1011	Hydrolase
TREBR_RS13025	COG4753	response regulator
TREBR_RS13025	COG2207	Transcriptional regulator
TREBR_RS13030	COG2972	Histidine kinase
TREBR_RS13055	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TREBR_RS13070	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TREBR_RS13230	COG1136	(ABC) transporter
TREBR_RS13230	COG0577	efflux transmembrane transporter activity
TREBR_RS13270	COG1609	Transcriptional regulator
TREBR_RS13290	COG0395	ABC-type sugar transport system, permease component
TREBR_RS13295	COG1175	transmembrane transport
TREBR_RS13310	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TREBR_RS13315	COG0187	DNA topoisomerase II activity
TREBR_RS13345	COG2226	methyltransferase
TREBR_RS13350	COG0581	inorganic phosphate transmembrane transporter activity
TREBR_RS13365	COG1554	hydrolase, family 65, central catalytic
TREBR_RS13370	COG1309	transcriptional regulator
TREBR_RS13380	COG2190	(PTS) system
TREBR_RS13380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TREBR_RS13380	COG1263	PTS System
TREBR_RS13385	COG2207	Transcriptional regulator
TREBR_RS13385	COG4753	response regulator
TREBR_RS13390	COG1388	LysM domain
TREBR_RS13390	COG0791	NLP P60 protein
TREBR_RS13405	COG0840	transmembrane signaling receptor activity
TREBR_RS13410	COG0167	dihydroorotate dehydrogenase activity
TREBR_RS13440	COG3437	response regulator, receiver
TREBR_RS13440	COG0784	Response regulator, receiver
TREBR_RS13460	COG0840	transmembrane signaling receptor activity
TREBR_RS13490	COG0438	transferase activity, transferring glycosyl groups
TREBR_RS13495	COG0438	transferase activity, transferring glycosyl groups
TREBR_RS13555	COG3328	transposase activity
TREBR_RS13570	COG0840	transmembrane signaling receptor activity
TREBR_RS13570	COG3290	protein histidine kinase activity
TREBR_RS13590	COG0840	transmembrane signaling receptor activity
TREBR_RS13630	COG3842	ATPase activity
TREBR_RS13635	COG1450	Type ii and iii secretion system protein
TREBR_RS13650	COG0840	transmembrane signaling receptor activity
TREBR_RS13660	COG2201	protein-glutamate methylesterase activity
TREBR_RS13670	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TREBR_RS13675	COG2207	Transcriptional regulator
TREBR_RS13675	COG3708	Transcriptional regulator
TREBR_RS13690	COG5002	protein histidine kinase activity
TREBR_RS13700	COG0438	transferase activity, transferring glycosyl groups
TREBR_RS13705	COG0438	transferase activity, transferring glycosyl groups
TREBR_RS13735	COG5001	Diguanylate cyclase
TREBR_RS13735	COG3300	MHYT domain
TREBR_RS13750	COG0037	tRNA processing
TREBR_RS13780	COG1216	Glycosyl transferase, family 2
TREBR_RS13785	COG3437	response regulator, receiver
TREBR_RS13790	COG0564	pseudouridine synthase activity
TREBR_RS13865	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TREBR_RS13870	COG0840	transmembrane signaling receptor activity
TREBR_RS13875	COG0840	transmembrane signaling receptor activity
TREBR_RS13900	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
TREBR_RS13920	COG2207	Transcriptional regulator
TREBR_RS13920	COG1917	Cupin 2, conserved barrel domain protein
TREBR_RS13925	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TREBR_RS13925	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TREBR_RS13930	COG1752	Esterase of the alpha-beta hydrolase superfamily