locus-tag	class	description
SPICA_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SPICA_RS00010	COG0592	DNA-directed DNA polymerase activity
SPICA_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SPICA_RS00025	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SPICA_RS00030	COG0594	ribonuclease P activity
SPICA_RS00035	COG0706	membrane insertase activity
SPICA_RS00040	COG1847	R3H domain protein
SPICA_RS00055	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SPICA_RS00075	COG1639	'signal transduction protein
SPICA_RS00080	COG1067	ATP-dependent peptidase activity
SPICA_RS00090	COG0840	transmembrane signaling receptor activity
SPICA_RS00100	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SPICA_RS00105	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SPICA_RS00135	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SPICA_RS00160	COG2972	Histidine kinase
SPICA_RS00165	COG3279	Response regulator of the LytR AlgR family
SPICA_RS00170	COG4213	ABC transporter substrate-binding protein
SPICA_RS00175	COG4213	ABC transporter substrate-binding protein
SPICA_RS00185	COG4214	carbohydrate transport
SPICA_RS00190	COG0534	Mate efflux family protein
SPICA_RS00200	COG0739	heme binding
SPICA_RS00210	COG1728	Protein conserved in bacteria
SPICA_RS00215	COG1774	PSP1 C-terminal conserved region
SPICA_RS00230	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SPICA_RS00240	COG0840	transmembrane signaling receptor activity
SPICA_RS00250	COG2755	lipolytic protein G-D-S-L family
SPICA_RS00275	COG1609	Transcriptional regulator
SPICA_RS00290	COG0494	nUDIX hydrolase
SPICA_RS00300	COG1175	transmembrane transport
SPICA_RS00305	COG0395	ABC-type sugar transport system, permease component
SPICA_RS00315	COG1074	ATP-dependent DNA helicase activity
SPICA_RS00330	COG1028	Short-chain dehydrogenase reductase Sdr
SPICA_RS00335	COG1349	DNA-binding transcription factor activity
SPICA_RS00345	COG1523	belongs to the glycosyl hydrolase 13 family
SPICA_RS00365	COG1454	alcohol dehydrogenase
SPICA_RS00370	COG2205	protein histidine kinase activity
SPICA_RS00410	COG0745	RESPONSE REGULATOR receiver
SPICA_RS00420	COG1523	belongs to the glycosyl hydrolase 13 family
SPICA_RS00435	COG3833	ABC-type maltose transport systems, permease component
SPICA_RS00440	COG1175	transmembrane transport
SPICA_RS00465	COG4112	unkown
SPICA_RS00530	COG1487	ribonuclease activity
SPICA_RS00575	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SPICA_RS00580	COG4702	Belongs to the UPF0303 family
SPICA_RS00595	COG4585	Histidine kinase
SPICA_RS00600	COG2197	response regulator
SPICA_RS00610	COG1879	ABC-type sugar transport system periplasmic component
SPICA_RS00615	COG1879	ABC-type sugar transport system periplasmic component
SPICA_RS00620	COG1129	ABC transporter
SPICA_RS00625	COG1172	Belongs to the binding-protein-dependent transport system permease family
SPICA_RS00630	COG0246	Mannitol dehydrogenase
SPICA_RS00655	COG0543	2 iron, 2 sulfur cluster binding
SPICA_RS00660	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SPICA_RS00660	COG0493	'glutamate synthase
SPICA_RS00665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPICA_RS00670	COG0737	Belongs to the 5'-nucleotidase family
SPICA_RS00695	COG1047	Peptidyl-prolyl cis-trans
SPICA_RS00720	COG0395	ABC-type sugar transport system, permease component
SPICA_RS00725	COG1175	transmembrane transport
SPICA_RS00730	COG1653	transport
SPICA_RS00735	COG2197	response regulator
SPICA_RS00740	COG4585	Histidine kinase
SPICA_RS00745	COG0719	Fe-S assembly protein
SPICA_RS00750	COG0396	ATPase activity
SPICA_RS00795	COG3706	GGDEF domain
SPICA_RS00800	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPICA_RS00800	COG3116	cell division
SPICA_RS00805	COG0084	hydrolase, TatD family'
SPICA_RS00825	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPICA_RS00825	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPICA_RS00830	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SPICA_RS00835	COG0351	phosphomethylpyrimidine kinase
SPICA_RS00840	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SPICA_RS00860	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SPICA_RS00860	COG0512	Glutamine amidotransferase of anthranilate synthase
SPICA_RS00870	COG0133	tryptophan synthase activity
SPICA_RS00875	COG0159	tryptophan synthase activity
SPICA_RS00885	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SPICA_RS00890	COG2900	Belongs to the SlyX family
SPICA_RS00895	COG0205	6-phosphofructokinase activity
SPICA_RS00910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPICA_RS00910	COG0784	Response regulator, receiver
SPICA_RS00910	COG2198	Histidine kinase
SPICA_RS00910	COG2205	protein histidine kinase activity
SPICA_RS00915	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPICA_RS00955	COG0483	inositol monophosphate 1-phosphatase activity
SPICA_RS00970	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SPICA_RS00975	COG2205	protein histidine kinase activity
SPICA_RS00975	COG3850	Histidine kinase
SPICA_RS00975	COG3437	response regulator, receiver
SPICA_RS00975	COG4999	Histidine kinase
SPICA_RS00980	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SPICA_RS00990	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SPICA_RS00995	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SPICA_RS01000	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPICA_RS01055	COG0395	ABC-type sugar transport system, permease component
SPICA_RS01060	COG1175	transmembrane transport
SPICA_RS01070	COG2197	response regulator
SPICA_RS01075	COG4585	Histidine kinase
SPICA_RS01115	COG3012	SEC-C Motif Domain Protein
SPICA_RS01120	COG0697	spore germination
SPICA_RS01130	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPICA_RS01155	COG1842	Phage shock protein A
SPICA_RS01195	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPICA_RS01200	COG0793	Belongs to the peptidase S41A family
SPICA_RS01200	COG3409	Peptidoglycan-binding domain 1 protein
SPICA_RS01210	COG0455	bacterial-type flagellum organization
SPICA_RS01220	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SPICA_RS01225	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SPICA_RS01230	COG0071	Belongs to the small heat shock protein (HSP20) family
SPICA_RS01240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPICA_RS01240	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPICA_RS01240	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPICA_RS01245	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SPICA_RS01255	COG1929	Belongs to the glycerate kinase type-1 family
SPICA_RS01260	COG3835	regulator
SPICA_RS01270	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SPICA_RS01275	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SPICA_RS01290	COG2814	Major facilitator Superfamily
SPICA_RS01350	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SPICA_RS01355	COG1285	pathogenesis
SPICA_RS01375	COG1070	Carbohydrate kinase
SPICA_RS01380	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPICA_RS01385	COG2885	chlorophyll binding
SPICA_RS01450	COG1328	CTP reductase activity
SPICA_RS01455	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPICA_RS01490	COG1022	Amp-dependent synthetase and ligase
SPICA_RS01510	COG0326	Molecular chaperone. Has ATPase activity
SPICA_RS01530	COG1132	(ABC) transporter
SPICA_RS01550	COG1028	Short-chain dehydrogenase reductase Sdr
SPICA_RS01560	COG2197	response regulator
SPICA_RS01570	COG1653	transport
SPICA_RS01575	COG1175	transmembrane transport
SPICA_RS01580	COG0395	ABC-type sugar transport system, permease component
SPICA_RS01585	COG2358	TRAP transporter, solute receptor (TAXI family
SPICA_RS01620	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPICA_RS01635	COG0396	ATPase activity
SPICA_RS01645	COG2249	NAD(P)H dehydrogenase (quinone) activity
SPICA_RS01650	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPICA_RS01670	COG0058	SHG alpha-glucan phosphorylase activity
SPICA_RS01680	COG1595	DNA-templated transcription, initiation
SPICA_RS01700	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SPICA_RS01715	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPICA_RS01720	COG1196	nuclear chromosome segregation
SPICA_RS01720	COG0739	heme binding
SPICA_RS01720	COG0741	lytic transglycosylase activity
SPICA_RS01750	COG0142	geranyltranstransferase activity
SPICA_RS01755	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
SPICA_RS01775	COG1940	carbohydrate kinase activity
SPICA_RS01775	COG1846	Transcriptional regulator
SPICA_RS01780	COG1653	transport
SPICA_RS01785	COG1175	transmembrane transport
SPICA_RS01790	COG0395	ABC-type sugar transport system, permease component
SPICA_RS01795	COG3459	Glycosyltransferase 36 associated
SPICA_RS01810	COG1918	ferrous iron import across plasma membrane
SPICA_RS01810	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SPICA_RS01815	COG4221	oxidoreductase activity
SPICA_RS01820	COG1674	ftsk spoiiie
SPICA_RS01845	COG1030	water channel activity
SPICA_RS01850	COG4864	UPF0365 protein
SPICA_RS01875	COG2211	Major facilitator Superfamily
SPICA_RS01885	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPICA_RS01895	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SPICA_RS01900	COG0250	Participates in transcription elongation, termination and antitermination
SPICA_RS01905	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SPICA_RS01910	COG0081	regulation of translation
SPICA_RS01915	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SPICA_RS01925	COG0085	RNA polymerase activity
SPICA_RS01940	COG0049	tRNA binding
SPICA_RS01945	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SPICA_RS01950	COG0051	transcription antitermination factor activity, RNA binding
SPICA_RS01955	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SPICA_RS01960	COG0088	Forms part of the polypeptide exit tunnel
SPICA_RS01965	COG0089	rRNA binding
SPICA_RS01970	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SPICA_RS01975	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SPICA_RS01980	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SPICA_RS01985	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SPICA_RS01995	COG0255	Belongs to the universal ribosomal protein uL29 family
SPICA_RS02000	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SPICA_RS02005	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SPICA_RS02010	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SPICA_RS02015	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SPICA_RS02020	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SPICA_RS02025	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SPICA_RS02030	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SPICA_RS02035	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SPICA_RS02045	COG0200	Binds to the 23S rRNA
SPICA_RS02055	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SPICA_RS02065	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SPICA_RS02070	COG0202	RNA polymerase activity
SPICA_RS02075	COG0203	ribosomal protein L17
SPICA_RS02115	COG2890	protein-(glutamine-N5) methyltransferase activity
SPICA_RS02120	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SPICA_RS02125	COG0457	Tetratricopeptide repeat
SPICA_RS02130	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SPICA_RS02150	COG0459	protein refolding
SPICA_RS02155	COG1760	l-serine dehydratase
SPICA_RS02160	COG1760	l-serine dehydratase
SPICA_RS02170	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPICA_RS02175	COG0328	RNA-DNA hybrid ribonuclease activity
SPICA_RS02180	COG4443	Transcriptional Coactivator p15 (PC4)
SPICA_RS02210	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SPICA_RS02225	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPICA_RS02290	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SPICA_RS02305	COG0237	dephospho-CoA kinase activity
SPICA_RS02310	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPICA_RS02310	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPICA_RS02310	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SPICA_RS02330	COG1085	galactose-1-phosphate uridylyltransferase
SPICA_RS02340	COG0668	transmembrane transport
SPICA_RS02345	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPICA_RS02355	COG1534	Rna-binding protein
SPICA_RS02370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SPICA_RS02395	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPICA_RS02430	COG1854	S-ribosylhomocysteine lyase activity
SPICA_RS02435	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPICA_RS02455	COG5001	Diguanylate cyclase
SPICA_RS02455	COG4251	negative regulation of phosphorylation
SPICA_RS02455	COG2203	Gaf domain
SPICA_RS02455	COG3706	GGDEF domain
SPICA_RS02490	COG0335	large ribosomal subunit rRNA binding
SPICA_RS02495	COG0336	Belongs to the RNA methyltransferase TrmD family
SPICA_RS02500	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SPICA_RS02505	COG1837	Belongs to the UPF0109 family
SPICA_RS02510	COG0228	four-way junction DNA binding
SPICA_RS02515	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPICA_RS02520	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SPICA_RS02535	COG0101	tRNA pseudouridine synthase activity
SPICA_RS02550	COG1609	Transcriptional regulator
SPICA_RS02560	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPICA_RS02585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SPICA_RS02590	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SPICA_RS02600	COG2089	acid synthase
SPICA_RS02605	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SPICA_RS02610	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SPICA_RS02620	COG1083	cytidylyl-transferase
SPICA_RS02625	COG1028	Short-chain dehydrogenase reductase Sdr
SPICA_RS02650	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SPICA_RS02650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SPICA_RS02655	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SPICA_RS02665	COG1086	Polysaccharide biosynthesis protein
SPICA_RS02675	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SPICA_RS02685	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SPICA_RS02695	COG1091	dTDP-4-dehydrorhamnose reductase activity
SPICA_RS02740	COG1129	ABC transporter
SPICA_RS02765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SPICA_RS02775	COG0724	RNA recognition motif
SPICA_RS02785	COG0148	phosphopyruvate hydratase activity
SPICA_RS02805	COG1575	Belongs to the MenA family. Type 1 subfamily
SPICA_RS02820	COG1752	Esterase of the alpha-beta hydrolase superfamily
SPICA_RS02825	COG1045	serine acetyltransferase
SPICA_RS02835	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SPICA_RS02840	COG0560	Phosphoserine phosphatase
SPICA_RS02845	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SPICA_RS02865	COG1196	nuclear chromosome segregation
SPICA_RS02885	COG1487	ribonuclease activity
SPICA_RS02895	COG0488	(ABC) transporter
SPICA_RS02925	COG0071	Belongs to the small heat shock protein (HSP20) family
SPICA_RS02930	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPICA_RS02940	COG1301	dicarboxylic acid transport
SPICA_RS02950	COG1309	transcriptional regulator
SPICA_RS02955	COG0116	Belongs to the methyltransferase superfamily
SPICA_RS02960	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
SPICA_RS02980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPICA_RS03005	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SPICA_RS03025	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
SPICA_RS03030	COG4209	transmembrane transport
SPICA_RS03035	COG0395	ABC-type sugar transport system, permease component
SPICA_RS03045	COG1312	Catalyzes the dehydration of D-mannonate
SPICA_RS03050	COG3661	Belongs to the glycosyl hydrolase 67 family
SPICA_RS03055	COG1472	Belongs to the glycosyl hydrolase 3 family
SPICA_RS03060	COG1486	melibiose metabolic process
SPICA_RS03070	COG1028	Short-chain dehydrogenase reductase Sdr
SPICA_RS03085	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SPICA_RS03090	COG1304	FMN binding
SPICA_RS03105	COG1802	Transcriptional regulator
SPICA_RS03110	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SPICA_RS03140	COG1175	transmembrane transport
SPICA_RS03145	COG0395	ABC-type sugar transport system, permease component
SPICA_RS03155	COG1609	Transcriptional regulator
SPICA_RS03160	COG0800	Aldolase
SPICA_RS03170	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
SPICA_RS03175	COG1028	Short-chain dehydrogenase reductase Sdr
SPICA_RS03180	COG1414	Transcriptional regulator
SPICA_RS03185	COG1904	glucuronate isomerase
SPICA_RS03190	COG0385	Bile acid
SPICA_RS03200	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SPICA_RS03210	COG4209	transmembrane transport
SPICA_RS03215	COG0395	ABC-type sugar transport system, permease component
SPICA_RS03220	COG1653	transport
SPICA_RS03255	COG0798	PFAM Bile acid sodium symporter
SPICA_RS03265	COG1245	4Fe-4S binding domain
SPICA_RS03265	COG2878	Part of a membrane complex involved in electron transport
SPICA_RS03270	COG4657	Part of a membrane complex involved in electron transport
SPICA_RS03275	COG4660	Part of a membrane complex involved in electron transport
SPICA_RS03280	COG4659	FMN binding
SPICA_RS03285	COG4658	electron transport chain
SPICA_RS03290	COG4656	Part of a membrane complex involved in electron transport
SPICA_RS03300	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
SPICA_RS03305	COG1687	branched-chain amino acid
SPICA_RS03310	COG0840	transmembrane signaling receptor activity
SPICA_RS03315	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SPICA_RS03320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SPICA_RS03330	COG0205	6-phosphofructokinase activity
SPICA_RS03345	COG0528	UMP kinase activity
SPICA_RS03350	COG1305	Transglutaminase-like
SPICA_RS03370	COG0215	cysteine-tRNA ligase activity
SPICA_RS03375	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SPICA_RS03425	COG2003	Belongs to the UPF0758 family
SPICA_RS03430	COG1528	Iron-storage protein
SPICA_RS03440	COG0156	8-amino-7-oxononanoate synthase activity
SPICA_RS03490	COG1122	ATPase activity
SPICA_RS03500	COG0745	RESPONSE REGULATOR receiver
SPICA_RS03500	COG4191	Histidine kinase
SPICA_RS03500	COG2205	protein histidine kinase activity
SPICA_RS03510	COG2204	response regulator
SPICA_RS03560	COG2894	cell division
SPICA_RS03570	COG0450	alkyl hydroperoxide reductase
SPICA_RS03575	COG3604	Transcriptional regulator
SPICA_RS03580	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SPICA_RS03595	COG1653	transport
SPICA_RS03600	COG1175	transmembrane transport
SPICA_RS03605	COG0395	ABC-type sugar transport system, permease component
SPICA_RS03610	COG3534	alpha-L-arabinofuranosidase
SPICA_RS03630	COG2801	Transposase and inactivated derivatives
SPICA_RS03635	COG0432	Pfam Uncharacterised protein family UPF0047
SPICA_RS03645	COG1164	Oligoendopeptidase f
SPICA_RS03700	COG0745	RESPONSE REGULATOR receiver
SPICA_RS03705	COG5002	protein histidine kinase activity
SPICA_RS03710	COG1609	Transcriptional regulator
SPICA_RS03720	COG1175	transmembrane transport
SPICA_RS03725	COG0395	ABC-type sugar transport system, permease component
SPICA_RS03730	COG1501	Belongs to the glycosyl hydrolase 31 family
SPICA_RS03740	COG0667	Aldo Keto reductase
SPICA_RS03780	COG0488	(ABC) transporter
SPICA_RS03785	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPICA_RS03790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPICA_RS03795	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPICA_RS03795	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPICA_RS03800	COG1509	lysine 2,3-aminomutase activity
SPICA_RS03805	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SPICA_RS03810	COG1744	ABC transporter substrate-binding protein PnrA-like
SPICA_RS03815	COG3845	ABC transporter
SPICA_RS03820	COG4603	Belongs to the binding-protein-dependent transport system permease family
SPICA_RS03825	COG1079	Belongs to the binding-protein-dependent transport system permease family
SPICA_RS03830	COG0813	purine-nucleoside phosphorylase activity
SPICA_RS03840	COG0735	belongs to the Fur family
SPICA_RS03850	COG1609	Transcriptional regulator
SPICA_RS03860	COG1472	Belongs to the glycosyl hydrolase 3 family
SPICA_RS03865	COG5002	protein histidine kinase activity
SPICA_RS03875	COG0704	Plays a role in the regulation of phosphate uptake
SPICA_RS03885	COG0613	PHP domain protein
SPICA_RS03890	COG0402	S-adenosylhomocysteine deaminase activity
SPICA_RS03900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPICA_RS03920	COG0366	Alpha amylase catalytic
SPICA_RS03935	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPICA_RS03960	COG0018	arginyl-trna synthetase
SPICA_RS03965	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SPICA_RS03975	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SPICA_RS03980	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SPICA_RS03985	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SPICA_RS03995	COG0799	negative regulation of ribosome biogenesis
SPICA_RS04005	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SPICA_RS04020	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SPICA_RS04025	COG0037	tRNA processing
SPICA_RS04040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPICA_RS04050	COG2198	Histidine kinase
SPICA_RS04050	COG0643	Histidine kinase
SPICA_RS04060	COG2201	protein-glutamate methylesterase activity
SPICA_RS04065	COG0745	RESPONSE REGULATOR receiver
SPICA_RS04070	COG0835	chemotaxis
SPICA_RS04085	COG0481	GTPase activity
SPICA_RS04090	COG2604	Protein of unknown function DUF115
SPICA_RS04095	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SPICA_RS04120	COG0667	Aldo Keto reductase
SPICA_RS04135	COG1609	Transcriptional regulator
SPICA_RS04140	COG1869	D-ribose catabolic process
SPICA_RS04145	COG1129	ABC transporter
SPICA_RS04150	COG1172	Belongs to the binding-protein-dependent transport system permease family
SPICA_RS04155	COG1879	ABC-type sugar transport system periplasmic component
SPICA_RS04180	COG3507	Belongs to the glycosyl hydrolase 43 family
SPICA_RS04180	COG2382	esterase
SPICA_RS04180	COG3693	PFAM glycoside hydrolase, family 10
SPICA_RS04200	COG1653	transport
SPICA_RS04205	COG1175	transmembrane transport
SPICA_RS04210	COG0395	ABC-type sugar transport system, permease component
SPICA_RS04215	COG1609	Transcriptional regulator
SPICA_RS04230	COG0545	Peptidyl-prolyl cis-trans isomerase
SPICA_RS04235	COG0105	UTP biosynthetic process
SPICA_RS04245	COG0559	Belongs to the binding-protein-dependent transport system permease family
SPICA_RS04255	COG0411	ABC transporter
SPICA_RS04265	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SPICA_RS04270	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SPICA_RS04275	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPICA_RS04285	COG1472	Belongs to the glycosyl hydrolase 3 family
SPICA_RS04290	COG0492	ferredoxin-NADP+ reductase activity
SPICA_RS04295	COG0840	transmembrane signaling receptor activity
SPICA_RS04310	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPICA_RS04320	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SPICA_RS04330	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SPICA_RS04335	COG1475	DNA binding
SPICA_RS04390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPICA_RS04390	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPICA_RS04390	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPICA_RS04420	COG1006	Multisubunit Na H antiporter MnhC subunit
SPICA_RS04425	COG0651	ATP synthesis coupled electron transport
SPICA_RS04440	COG1215	transferase activity, transferring glycosyl groups
SPICA_RS04445	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SPICA_RS04450	COG0505	Belongs to the CarA family
SPICA_RS04455	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SPICA_RS04460	COG0426	domain, Protein
SPICA_RS04460	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SPICA_RS04470	COG2201	protein-glutamate methylesterase activity
SPICA_RS04490	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SPICA_RS04495	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SPICA_RS04500	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SPICA_RS04505	COG0137	argininosuccinate synthase activity
SPICA_RS04510	COG0165	Argininosuccinate lyase
SPICA_RS04525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SPICA_RS04550	COG0423	glycine-tRNA ligase activity
SPICA_RS04585	COG3328	transposase activity
SPICA_RS04650	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SPICA_RS04655	COG1744	ABC transporter substrate-binding protein PnrA-like
SPICA_RS04660	COG3845	ABC transporter
SPICA_RS04665	COG4603	Belongs to the binding-protein-dependent transport system permease family
SPICA_RS04670	COG1079	Belongs to the binding-protein-dependent transport system permease family
SPICA_RS04675	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SPICA_RS04685	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPICA_RS04705	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPICA_RS04710	COG2502	aspartate--ammonia ligase
SPICA_RS04715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPICA_RS04720	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SPICA_RS04725	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SPICA_RS04735	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SPICA_RS04750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPICA_RS04755	COG1396	sequence-specific DNA binding
SPICA_RS04760	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SPICA_RS04765	COG0066	3-isopropylmalate dehydratase activity
SPICA_RS04770	COG2814	Major facilitator Superfamily
SPICA_RS04775	COG1811	Na channel or pump
SPICA_RS04780	COG3842	ATPase activity
SPICA_RS04790	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
SPICA_RS04795	COG0557	exoribonuclease II activity
SPICA_RS04800	COG0527	aspartate kinase activity
SPICA_RS04805	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SPICA_RS04810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPICA_RS04825	COG0436	Aminotransferase
SPICA_RS04835	COG2801	Transposase and inactivated derivatives
SPICA_RS04855	COG0643	Histidine kinase
SPICA_RS04855	COG2198	Histidine kinase
SPICA_RS04860	COG0835	chemotaxis
SPICA_RS04870	COG2201	protein-glutamate methylesterase activity
SPICA_RS04880	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SPICA_RS04890	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SPICA_RS04900	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SPICA_RS04910	COG2204	response regulator
SPICA_RS04915	COG0425	Belongs to the sulfur carrier protein TusA family
SPICA_RS04925	COG2391	methyltransferase activity
SPICA_RS04945	COG2723	6-phospho-beta-galactosidase activity
SPICA_RS04950	COG1846	Transcriptional regulator
SPICA_RS04950	COG1940	carbohydrate kinase activity
SPICA_RS04955	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
SPICA_RS04960	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SPICA_RS04985	COG1181	Belongs to the D-alanine--D-alanine ligase family
SPICA_RS04990	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SPICA_RS05000	COG2078	PFAM AMMECR1 domain protein
SPICA_RS05010	COG0154	amidase activity
SPICA_RS05015	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SPICA_RS05020	COG0017	Asparaginyl-tRNA synthetase
SPICA_RS05035	COG2703	oxygen carrier activity
SPICA_RS05115	COG3458	cephalosporin-C deacetylase activity
SPICA_RS05130	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SPICA_RS05140	COG0564	pseudouridine synthase activity
SPICA_RS05145	COG0826	peptidase U32
SPICA_RS05155	COG2716	regulation of RNA biosynthetic process
SPICA_RS05160	COG0840	transmembrane signaling receptor activity
SPICA_RS05175	COG0534	Mate efflux family protein
SPICA_RS05205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SPICA_RS05210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPICA_RS05215	COG3630	sodium ion export across plasma membrane
SPICA_RS05220	COG5016	pyruvate
SPICA_RS05220	COG0511	ligase activity, forming carbon-carbon bonds
SPICA_RS05230	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SPICA_RS05250	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SPICA_RS05260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPICA_RS05285	COG0295	cytidine deaminase activity
SPICA_RS05290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPICA_RS05305	COG0564	pseudouridine synthase activity
SPICA_RS05315	COG1543	Belongs to the glycosyl hydrolase 57 family
SPICA_RS05330	COG2770	Histidine kinase
SPICA_RS05330	COG2208	phosphoserine phosphatase activity
SPICA_RS05350	COG0395	ABC-type sugar transport system, permease component
SPICA_RS05395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SPICA_RS05485	COG3328	transposase activity
SPICA_RS05505	COG0037	tRNA processing
SPICA_RS05520	COG1078	dGTPase activity
SPICA_RS05525	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SPICA_RS05545	COG1366	Belongs to the anti-sigma-factor antagonist family
SPICA_RS05555	COG0488	(ABC) transporter
SPICA_RS05560	COG1272	protein, Hemolysin III
SPICA_RS05565	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
SPICA_RS05590	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SPICA_RS05605	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SPICA_RS05620	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPICA_RS05625	COG0438	transferase activity, transferring glycosyl groups
SPICA_RS05640	COG0740	serine-type endopeptidase activity
SPICA_RS05645	COG0544	peptidyl-prolyl cis-trans isomerase activity
SPICA_RS05695	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SPICA_RS05700	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
SPICA_RS05710	COG2770	Histidine kinase
SPICA_RS05710	COG3437	response regulator, receiver
SPICA_RS05715	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SPICA_RS05720	COG0802	atpase or kinase
SPICA_RS05745	COG1334	flagellar protein FlaG
SPICA_RS05765	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPICA_RS05780	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SPICA_RS05795	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SPICA_RS05815	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPICA_RS05835	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SPICA_RS05835	COG0574	Belongs to the PEP-utilizing enzyme family
SPICA_RS05850	COG0280	phosphate acetyltransferase
SPICA_RS05870	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SPICA_RS05890	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SPICA_RS05895	COG1872	DUF167
SPICA_RS05915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SPICA_RS05935	COG1162	GTPase activity
SPICA_RS05940	COG1193	negative regulation of DNA recombination
SPICA_RS05955	COG1438	arginine binding
SPICA_RS05960	COG0166	Belongs to the GPI family
SPICA_RS05975	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SPICA_RS06005	COG0628	permease
SPICA_RS06010	COG3830	Belongs to the UPF0237 family
SPICA_RS06015	COG2848	UPF0210 protein
SPICA_RS06025	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SPICA_RS06055	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPICA_RS06065	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SPICA_RS06065	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SPICA_RS06075	COG4191	Histidine kinase
SPICA_RS06080	COG2204	response regulator
SPICA_RS06090	COG0330	HflC and HflK could
SPICA_RS06095	COG0330	HflC and HflK could
SPICA_RS06105	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SPICA_RS06110	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SPICA_RS06115	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SPICA_RS06120	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SPICA_RS06130	COG0736	holo-[acyl-carrier-protein] synthase activity
SPICA_RS06140	COG0101	tRNA pseudouridine synthase activity
SPICA_RS06145	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SPICA_RS06150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPICA_RS06155	COG1120	ATPase activity
SPICA_RS06165	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SPICA_RS06180	COG1253	flavin adenine dinucleotide binding
SPICA_RS06195	COG0436	Aminotransferase
SPICA_RS06200	COG2604	Protein of unknown function DUF115
SPICA_RS06205	COG0768	penicillin binding
SPICA_RS06215	COG0739	heme binding
SPICA_RS06220	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SPICA_RS06230	COG0726	polysaccharide deacetylase
SPICA_RS06240	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SPICA_RS06245	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
SPICA_RS06255	COG1480	7TM receptor with intracellular HD hydrolase
SPICA_RS06260	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SPICA_RS06285	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SPICA_RS06295	COG0552	protein localization to endoplasmic reticulum
SPICA_RS06305	COG4591	ABC-type transport system involved in lipoprotein release permease component
SPICA_RS06310	COG1136	(ABC) transporter
SPICA_RS06325	COG3869	Catalyzes the specific phosphorylation of arginine residues in
SPICA_RS06330	COG0542	response to heat
SPICA_RS06335	COG0179	Fumarylacetoacetate (FAA) hydrolase
SPICA_RS06345	COG0386	Belongs to the glutathione peroxidase family
SPICA_RS06350	COG1846	Transcriptional regulator
SPICA_RS06355	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SPICA_RS06360	COG1205	dead DEAH box helicase
SPICA_RS06360	COG1111	helicase
SPICA_RS06380	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SPICA_RS06385	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SPICA_RS06410	COG0438	transferase activity, transferring glycosyl groups
SPICA_RS06415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPICA_RS06430	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SPICA_RS06435	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SPICA_RS06445	COG0297	glycogen (starch) synthase activity
SPICA_RS06460	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPICA_RS06465	COG2267	carboxylic ester hydrolase activity
SPICA_RS06470	COG0617	tRNA 3'-terminal CCA addition
SPICA_RS06505	COG4658	electron transport chain
SPICA_RS06530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPICA_RS06530	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPICA_RS06540	COG1234	tRNA 3'-trailer cleavage
SPICA_RS06545	COG1131	(ABC) transporter
SPICA_RS06605	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SPICA_RS06615	COG0681	Belongs to the peptidase S26 family
SPICA_RS06625	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPICA_RS06635	COG0574	Belongs to the PEP-utilizing enzyme family
SPICA_RS06635	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SPICA_RS06650	COG1116	anion transmembrane transporter activity
SPICA_RS06660	COG1122	ATPase activity
SPICA_RS06665	COG1268	BioY protein
SPICA_RS06670	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SPICA_RS06670	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SPICA_RS06675	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SPICA_RS06680	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SPICA_RS06700	COG0301	tRNA thio-modification
SPICA_RS06705	COG1104	cysteine desulfurase activity
SPICA_RS06715	COG0527	aspartate kinase activity
SPICA_RS06715	COG0460	homoserine dehydrogenase
SPICA_RS06720	COG0436	Aminotransferase
SPICA_RS06730	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SPICA_RS06740	COG2801	Transposase and inactivated derivatives
SPICA_RS06750	COG1091	dTDP-4-dehydrorhamnose reductase activity
SPICA_RS06785	COG0124	histidyl-tRNA synthetase
SPICA_RS06800	COG2089	acid synthase
SPICA_RS06810	COG0217	transcriptional regulatory protein
SPICA_RS06815	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SPICA_RS06820	COG0632	four-way junction helicase activity
SPICA_RS06825	COG2255	four-way junction helicase activity
SPICA_RS06830	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SPICA_RS06840	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SPICA_RS06850	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SPICA_RS06870	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SPICA_RS06875	COG0779	Required for maturation of 30S ribosomal subunits
SPICA_RS06885	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SPICA_RS06890	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SPICA_RS06895	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SPICA_RS06905	COG1185	polyribonucleotide nucleotidyltransferase activity
SPICA_RS06910	COG0612	Peptidase, M16
SPICA_RS06925	COG0343	queuine tRNA-ribosyltransferase activity
SPICA_RS06940	COG1747	RNA polymerase binding
SPICA_RS06940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SPICA_RS06950	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SPICA_RS06970	COG1490	D-aminoacyl-tRNA deacylase activity
SPICA_RS06975	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPICA_RS06980	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SPICA_RS06995	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SPICA_RS07005	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SPICA_RS07010	COG0539	negative regulation of cytoplasmic translation
SPICA_RS07040	COG0772	Belongs to the SEDS family
SPICA_RS07045	COG0768	penicillin binding
SPICA_RS07060	COG1077	Cell shape determining protein MreB Mrl
SPICA_RS07075	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPICA_RS07080	COG0358	DNA primase activity
SPICA_RS07085	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPICA_RS07090	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SPICA_RS07090	COG1404	Belongs to the peptidase S8 family
SPICA_RS07100	COG1234	tRNA 3'-trailer cleavage
SPICA_RS07145	COG0571	ribonuclease III activity
SPICA_RS07150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPICA_RS07155	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SPICA_RS07165	COG1413	lyase activity
SPICA_RS07180	COG0587	DNA-directed DNA polymerase activity
SPICA_RS07195	COG0424	maF-like protein
SPICA_RS07200	COG0052	Belongs to the universal ribosomal protein uS2 family
SPICA_RS07205	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SPICA_RS07210	COG0233	cytoplasmic translational termination
SPICA_RS07215	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SPICA_RS07220	COG0575	Belongs to the CDS family
SPICA_RS07225	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SPICA_RS07230	COG0750	zinc metalloprotease
SPICA_RS07245	COG0305	Participates in initiation and elongation during chromosome replication
SPICA_RS07250	COG0359	binds to the 23S rRNA
SPICA_RS07260	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SPICA_RS07265	COG0629	single-stranded DNA binding
SPICA_RS07270	COG0360	Binds together with S18 to 16S ribosomal RNA
SPICA_RS07285	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SPICA_RS07305	COG4399	Belongs to the UPF0754 family
SPICA_RS07315	COG0494	nUDIX hydrolase
SPICA_RS07330	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SPICA_RS07330	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SPICA_RS07340	COG0653	protein targeting
SPICA_RS07365	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SPICA_RS07390	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SPICA_RS07400	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SPICA_RS07405	COG1132	(ABC) transporter
SPICA_RS07430	COG3475	LICD family
SPICA_RS07505	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SPICA_RS07510	COG1643	Atp-dependent helicase
SPICA_RS07525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SPICA_RS07530	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SPICA_RS07600	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SPICA_RS07615	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SPICA_RS07630	COG1394	ATPase activity, coupled to movement of substances
SPICA_RS07635	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
SPICA_RS07640	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
SPICA_RS07650	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
SPICA_RS07670	COG2204	response regulator
SPICA_RS07675	COG5002	protein histidine kinase activity
SPICA_RS07685	COG1286	toxin biosynthetic process
SPICA_RS07690	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SPICA_RS07715	COG0835	chemotaxis
SPICA_RS07735	COG1191	sigma factor activity
SPICA_RS07760	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SPICA_RS07765	COG1684	flagellar biosynthetic protein fliR
SPICA_RS07770	COG1987	bacterial-type flagellum assembly
SPICA_RS07775	COG1338	Plays a role in the flagellum-specific transport system
SPICA_RS07785	COG1776	CheC inhibitor of MCP methylation
SPICA_RS07785	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SPICA_RS07790	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SPICA_RS07795	COG1580	Controls the rotational direction of flagella during chemotaxis
SPICA_RS07800	COG1360	Flagellar Motor Protein
SPICA_RS07810	COG1582	Flagellar protein (FlbD)
SPICA_RS07820	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
SPICA_RS07845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SPICA_RS07880	COG1598	PFAM Uncharacterised protein family UPF0150
SPICA_RS07885	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SPICA_RS07890	COG1573	uracil-dna glycosylase
SPICA_RS07895	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPICA_RS07910	COG1321	iron dependent repressor
SPICA_RS07930	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SPICA_RS07935	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPICA_RS07935	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SPICA_RS07940	COG1979	alcohol dehydrogenase
SPICA_RS07970	COG3328	transposase activity
SPICA_RS08020	COG1102	Psort location Cytoplasmic, score
SPICA_RS08025	COG1561	YicC-like family, N-terminal region
SPICA_RS08035	COG0285	dihydrofolate synthase activity
SPICA_RS08045	COG0564	pseudouridine synthase activity
SPICA_RS08065	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SPICA_RS08090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPICA_RS08095	COG0785	Cytochrome C biogenesis protein
SPICA_RS08110	COG1166	arginine decarboxylase activity
SPICA_RS08135	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SPICA_RS08150	COG0254	rRNA binding
SPICA_RS08155	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SPICA_RS08160	COG1058	Belongs to the CinA family
SPICA_RS08160	COG1546	Belongs to the CinA family
SPICA_RS08180	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SPICA_RS08190	COG0268	Binds directly to 16S ribosomal RNA
SPICA_RS08205	COG1199	ATP-dependent helicase activity
SPICA_RS08235	COG3706	GGDEF domain
SPICA_RS08265	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SPICA_RS08270	COG0372	Belongs to the citrate synthase family
SPICA_RS08275	COG0017	Asparaginyl-tRNA synthetase
SPICA_RS08280	COG1686	Belongs to the peptidase S11 family
SPICA_RS08310	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
SPICA_RS08320	COG0731	radical SAM domain protein
SPICA_RS08325	COG1570	exodeoxyribonuclease VII activity
SPICA_RS08330	COG1722	exodeoxyribonuclease VII activity
SPICA_RS08335	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SPICA_RS08355	COG0084	hydrolase, TatD family'
SPICA_RS08385	COG0004	ammonium transporteR
SPICA_RS08395	COG1966	Carbon starvation protein
SPICA_RS08405	COG0003	Pfam Anion-transporting ATPase
SPICA_RS08425	COG1725	Transcriptional regulator
SPICA_RS08430	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SPICA_RS08440	COG4865	methylaspartate mutase activity
SPICA_RS08445	COG3799	methylaspartate ammonia-lyase activity
SPICA_RS08475	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SPICA_RS08485	COG1157	protein secretion by the type III secretion system
SPICA_RS08490	COG1317	bacterial-type flagellum organization
SPICA_RS08500	COG1766	The M ring may be actively involved in energy transduction
SPICA_RS08515	COG1815	bacterial-type flagellum-dependent cell motility
SPICA_RS08520	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SPICA_RS08525	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SPICA_RS08530	COG4974	Belongs to the 'phage' integrase family
SPICA_RS08535	COG0551	DNA topoisomerase type I activity
SPICA_RS08535	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPICA_RS08540	COG0758	DNA mediated transformation
SPICA_RS08570	COG0772	Belongs to the SEDS family
SPICA_RS08575	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SPICA_RS08580	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPICA_RS08590	COG0275	rRNA processing
SPICA_RS08595	COG2001	Belongs to the MraZ family
SPICA_RS08625	COG0191	fructose-bisphosphate aldolase activity
SPICA_RS08645	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SPICA_RS08655	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
SPICA_RS08665	COG1671	Belongs to the UPF0178 family
SPICA_RS08670	COG3437	response regulator, receiver
SPICA_RS08670	COG0784	Response regulator, receiver
SPICA_RS08675	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SPICA_RS08685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPICA_RS08690	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPICA_RS08695	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPICA_RS08695	COG0022	dehydrogenase e1 component
SPICA_RS08700	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPICA_RS08710	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPICA_RS08715	COG0581	inorganic phosphate transmembrane transporter activity
SPICA_RS08720	COG0573	inorganic phosphate transmembrane transporter activity
SPICA_RS08725	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPICA_RS08740	COG0170	dolichyl monophosphate biosynthetic process
SPICA_RS08775	COG4659	FMN binding
SPICA_RS08785	COG0095	Lipoate-protein ligase
SPICA_RS08795	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SPICA_RS08805	COG1715	Restriction endonuclease
SPICA_RS08910	COG1715	Restriction endonuclease
SPICA_RS08935	COG1715	Restriction endonuclease
SPICA_RS09050	COG0406	alpha-ribazole phosphatase activity
SPICA_RS09115	COG3328	transposase activity
SPICA_RS09120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPICA_RS09160	COG0497	DNA recombination
SPICA_RS09165	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SPICA_RS09175	COG0835	chemotaxis
SPICA_RS09210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPICA_RS09215	COG0024	Methionine aminopeptidase
SPICA_RS09220	COG0484	heat shock protein binding
SPICA_RS09235	COG1394	ATPase activity, coupled to movement of substances
SPICA_RS09240	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
SPICA_RS09245	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
SPICA_RS09265	COG1269	ATP hydrolysis coupled proton transport
SPICA_RS09280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPICA_RS09285	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SPICA_RS09290	COG0149	triose-phosphate isomerase activity
SPICA_RS09295	COG0126	phosphoglycerate kinase activity
SPICA_RS09300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SPICA_RS09310	COG0525	valine-tRNA ligase activity
SPICA_RS09315	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SPICA_RS09320	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SPICA_RS09325	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SPICA_RS09330	COG1862	Preprotein translocase
SPICA_RS09345	COG2033	superoxide reductase activity
SPICA_RS09350	COG1592	Rubrerythrin
SPICA_RS09380	COG0616	signal peptide processing
SPICA_RS09390	COG0542	response to heat
SPICA_RS09395	COG0737	Belongs to the 5'-nucleotidase family
SPICA_RS09405	COG0519	Catalyzes the synthesis of GMP from XMP
SPICA_RS09410	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SPICA_RS09415	COG0516	GMP reductase activity
SPICA_RS09415	COG0517	IMP dehydrogenase activity
SPICA_RS09420	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPICA_RS09430	COG0561	phosphatase activity
SPICA_RS09460	COG0070	glutamate synthase
SPICA_RS09460	COG0069	glutamate synthase activity
SPICA_RS09460	COG0067	glutamate synthase
SPICA_RS09470	COG2972	Histidine kinase
SPICA_RS09475	COG2207	Transcriptional regulator
SPICA_RS09475	COG4753	response regulator
SPICA_RS09480	COG4213	ABC transporter substrate-binding protein
SPICA_RS09495	COG4211	Belongs to the binding-protein-dependent transport system permease family
SPICA_RS09500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPICA_RS09525	COG1160	GTP binding
SPICA_RS09530	COG1027	Aspartate ammonia-lyase
SPICA_RS09535	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SPICA_RS09575	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPICA_RS09575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPICA_RS09575	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPICA_RS09590	COG2814	Major facilitator Superfamily
SPICA_RS09600	COG0420	3'-5' exonuclease activity
SPICA_RS09605	COG0419	ATPase involved in DNA repair
SPICA_RS09615	COG1335	isochorismatase
SPICA_RS09620	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPICA_RS09635	COG1175	transmembrane transport
SPICA_RS09640	COG0395	ABC-type sugar transport system, permease component
SPICA_RS09655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPICA_RS09660	COG0765	amino acid transport
SPICA_RS09665	COG0037	tRNA processing
SPICA_RS09695	COG0395	ABC-type sugar transport system, permease component
SPICA_RS09700	COG1175	transmembrane transport
SPICA_RS09705	COG1653	transport
SPICA_RS09710	COG2188	Transcriptional regulator
SPICA_RS09750	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SPICA_RS09780	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SPICA_RS09785	COG1518	maintenance of DNA repeat elements
SPICA_RS09815	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SPICA_RS09840	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPICA_RS09840	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPICA_RS09845	COG0556	nucleotide-excision repair
SPICA_RS09860	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPICA_RS09860	COG0321	lipoyl(octanoyl) transferase activity
SPICA_RS09865	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SPICA_RS09895	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SPICA_RS09945	COG0167	dihydroorotate dehydrogenase activity
SPICA_RS09950	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SPICA_RS09965	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPICA_RS09980	COG0587	DNA-directed DNA polymerase activity
SPICA_RS09985	COG1609	Transcriptional regulator
SPICA_RS09990	COG0436	Aminotransferase
SPICA_RS10010	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPICA_RS10010	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPICA_RS10025	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SPICA_RS10025	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SPICA_RS10030	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPICA_RS10050	COG0563	adenylate kinase activity
SPICA_RS10055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPICA_RS10060	COG1349	DNA-binding transcription factor activity
SPICA_RS10065	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPICA_RS10070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPICA_RS10095	COG1063	alcohol dehydrogenase
SPICA_RS10120	COG1373	ATPase (AAA superfamily
SPICA_RS10155	COG0577	efflux transmembrane transporter activity
SPICA_RS10160	COG0577	efflux transmembrane transporter activity
SPICA_RS10160	COG1136	(ABC) transporter
SPICA_RS10165	COG1136	(ABC) transporter
SPICA_RS10175	COG5002	protein histidine kinase activity
SPICA_RS10180	COG0745	RESPONSE REGULATOR receiver
SPICA_RS10190	COG4214	carbohydrate transport
SPICA_RS10200	COG4213	ABC transporter substrate-binding protein
SPICA_RS10205	COG4213	ABC transporter substrate-binding protein
SPICA_RS10210	COG2197	response regulator
SPICA_RS10215	COG2972	Histidine kinase
SPICA_RS10225	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
SPICA_RS10230	COG0542	response to heat
SPICA_RS10235	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SPICA_RS10245	COG0708	Exodeoxyribonuclease III
SPICA_RS10270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPICA_RS10290	COG1956	GAF domain-containing protein
SPICA_RS10305	COG0601	transmembrane transport
SPICA_RS10310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPICA_RS10315	COG0444	Belongs to the ABC transporter superfamily
SPICA_RS10320	COG4608	Belongs to the ABC transporter superfamily
SPICA_RS10325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SPICA_RS10335	COG1028	Short-chain dehydrogenase reductase Sdr
SPICA_RS10340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPICA_RS10345	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SPICA_RS10350	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SPICA_RS10360	COG0439	Biotin carboxylase
SPICA_RS10365	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SPICA_RS10370	COG0825	malonyl-CoA metabolic process
SPICA_RS10380	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPICA_RS10390	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SPICA_RS10400	COG0629	single-stranded DNA binding
SPICA_RS10405	COG0826	peptidase U32
SPICA_RS10410	COG2095	MarC family integral membrane protein
SPICA_RS10430	COG0095	Lipoate-protein ligase
SPICA_RS10480	COG5002	protein histidine kinase activity
SPICA_RS10480	COG5001	Diguanylate cyclase
SPICA_RS10490	COG0205	6-phosphofructokinase activity
SPICA_RS10500	COG1501	Belongs to the glycosyl hydrolase 31 family
SPICA_RS10510	COG2211	Major facilitator Superfamily
SPICA_RS10525	COG1175	transmembrane transport
SPICA_RS10545	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SPICA_RS10560	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SPICA_RS10585	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPICA_RS10600	COG3959	Transketolase, thiamine diphosphate binding domain
SPICA_RS10605	COG3958	Transketolase
SPICA_RS10610	COG0698	ribose 5-phosphate isomerase
SPICA_RS10615	COG1454	alcohol dehydrogenase
SPICA_RS10635	COG0671	phosphoesterase, PA-phosphatase related
SPICA_RS10655	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SPICA_RS10700	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SPICA_RS10700	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SPICA_RS10705	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SPICA_RS10710	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPICA_RS10730	COG0848	biopolymer transport protein
SPICA_RS10735	COG0811	peptide transport
SPICA_RS10780	COG3328	transposase activity
SPICA_RS10785	COG2200	EAL domain
SPICA_RS10790	COG0840	transmembrane signaling receptor activity
SPICA_RS10795	COG1162	GTPase activity
SPICA_RS10800	COG2197	response regulator
SPICA_RS10810	COG4555	ABC transporter
SPICA_RS10845	COG3842	ATPase activity
SPICA_RS10855	COG1177	transmembrane transport
SPICA_RS10860	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SPICA_RS10865	COG0009	L-threonylcarbamoyladenylate synthase
SPICA_RS10875	COG2204	response regulator
SPICA_RS10880	COG2972	Histidine kinase
SPICA_RS10885	COG1609	Transcriptional regulator
SPICA_RS10895	COG1172	Belongs to the binding-protein-dependent transport system permease family
SPICA_RS10905	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
SPICA_RS10910	COG1121	(ABC) transporter
SPICA_RS10915	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPICA_RS10930	COG0697	spore germination
SPICA_RS10960	COG0583	DNA-binding transcription factor activity
SPICA_RS10965	COG2855	membrane
SPICA_RS10980	COG1914	H( )-stimulated, divalent metal cation uptake system
SPICA_RS10990	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SPICA_RS11045	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SPICA_RS11060	COG2801	Transposase and inactivated derivatives
SPICA_RS11230	COG2972	Histidine kinase
SPICA_RS11235	COG2207	Transcriptional regulator
SPICA_RS11235	COG4753	response regulator
SPICA_RS11240	COG1879	ABC-type sugar transport system periplasmic component
SPICA_RS11245	COG1879	ABC-type sugar transport system periplasmic component
SPICA_RS11250	COG1129	ABC transporter
SPICA_RS11255	COG1172	Belongs to the binding-protein-dependent transport system permease family
SPICA_RS11260	COG1172	Belongs to the binding-protein-dependent transport system permease family
SPICA_RS11275	COG0395	ABC-type sugar transport system, permease component
SPICA_RS11285	COG1609	Transcriptional regulator
SPICA_RS11335	COG0123	including yeast histone deacetylase and acetoin utilization protein
SPICA_RS11360	COG1136	(ABC) transporter
SPICA_RS11370	COG1725	Transcriptional regulator
SPICA_RS11390	COG4154	Belongs to the RbsD FucU family
SPICA_RS11400	COG1063	alcohol dehydrogenase
SPICA_RS11405	COG1105	Belongs to the carbohydrate kinase PfkB family
SPICA_RS11415	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SPICA_RS11425	COG3711	transcriptional antiterminator
SPICA_RS11440	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SPICA_RS11445	COG0534	Mate efflux family protein
SPICA_RS11455	COG0288	reversible hydration of carbon dioxide
SPICA_RS11470	COG2746	aminoglycoside 3-N-acetyltransferase activity
SPICA_RS11475	COG2217	Heavy metal translocating P-type atpase
SPICA_RS11480	COG0640	Transcriptional regulator
SPICA_RS11495	COG0494	nUDIX hydrolase
SPICA_RS11520	COG0659	secondary active sulfate transmembrane transporter activity
SPICA_RS11535	COG1132	(ABC) transporter
SPICA_RS11545	COG1132	(ABC) transporter
SPICA_RS11590	COG4585	Histidine kinase
SPICA_RS11595	COG2197	response regulator
SPICA_RS11600	COG1653	transport
SPICA_RS11605	COG1175	transmembrane transport
SPICA_RS11620	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SPICA_RS11640	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SPICA_RS11665	COG2272	Belongs to the type-B carboxylesterase lipase family
SPICA_RS11680	COG1247	-acetyltransferase
SPICA_RS11710	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SPICA_RS11720	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SPICA_RS11725	COG0714	Associated with various cellular activities
SPICA_RS11755	COG0714	Associated with various cellular activities
SPICA_RS11765	COG1172	Belongs to the binding-protein-dependent transport system permease family
SPICA_RS11770	COG1129	ABC transporter
SPICA_RS11775	COG1879	ABC-type sugar transport system periplasmic component
SPICA_RS11780	COG1879	ABC-type sugar transport system periplasmic component
SPICA_RS11785	COG2972	Histidine kinase
SPICA_RS11790	COG4753	response regulator
SPICA_RS11790	COG2207	Transcriptional regulator
SPICA_RS11795	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SPICA_RS11820	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SPICA_RS11830	COG1022	Amp-dependent synthetase and ligase
SPICA_RS11845	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SPICA_RS11850	COG0242	peptide deformylase activity
SPICA_RS11855	COG4953	penicillin-binding protein 1C
SPICA_RS11865	COG5001	Diguanylate cyclase
SPICA_RS11865	COG3706	GGDEF domain
SPICA_RS11865	COG4251	negative regulation of phosphorylation
SPICA_RS11865	COG2203	Gaf domain
SPICA_RS11870	COG2201	protein-glutamate methylesterase activity
SPICA_RS11875	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
SPICA_RS11880	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SPICA_RS11890	COG0835	chemotaxis
SPICA_RS11900	COG0643	Histidine kinase
SPICA_RS11900	COG2198	Histidine kinase
SPICA_RS11915	COG1063	alcohol dehydrogenase
SPICA_RS11920	COG0656	L-ascorbic acid biosynthetic process
SPICA_RS11930	COG1501	Belongs to the glycosyl hydrolase 31 family
SPICA_RS11935	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SPICA_RS11940	COG1193	negative regulation of DNA recombination
SPICA_RS11965	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SPICA_RS11970	COG0509	glycine decarboxylation via glycine cleavage system
SPICA_RS11975	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SPICA_RS11980	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SPICA_RS11995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SPICA_RS12005	COG2226	methyltransferase
SPICA_RS12025	COG0693	protein deglycase activity
SPICA_RS12030	COG0745	RESPONSE REGULATOR receiver
SPICA_RS12035	COG0784	Response regulator, receiver
SPICA_RS12035	COG2205	protein histidine kinase activity
SPICA_RS12035	COG5002	protein histidine kinase activity
SPICA_RS12040	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SPICA_RS12050	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SPICA_RS12090	COG0714	Associated with various cellular activities
SPICA_RS12115	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
SPICA_RS12130	COG0012	GTP binding
SPICA_RS12140	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPICA_RS12150	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SPICA_RS12170	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPICA_RS12185	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SPICA_RS12185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SPICA_RS12205	COG2183	response to ionizing radiation
SPICA_RS12220	COG3290	protein histidine kinase activity
SPICA_RS12220	COG0840	transmembrane signaling receptor activity
SPICA_RS12225	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SPICA_RS12230	COG3527	Alpha-acetolactate decarboxylase
SPICA_RS12240	COG0840	transmembrane signaling receptor activity
SPICA_RS12245	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SPICA_RS12250	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SPICA_RS12260	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPICA_RS12265	COG0138	bifunctional purine biosynthesis protein purh
SPICA_RS12270	COG0151	Belongs to the GarS family
SPICA_RS12275	COG1309	transcriptional regulator
SPICA_RS12280	COG0395	ABC-type sugar transport system, permease component
SPICA_RS12285	COG4209	transmembrane transport
SPICA_RS12295	COG1132	(ABC) transporter
SPICA_RS12300	COG1132	(ABC) transporter
SPICA_RS12320	COG0318	PFAM AMP-dependent synthetase and ligase
SPICA_RS12345	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SPICA_RS12350	COG0131	Imidazoleglycerol-phosphate dehydratase
SPICA_RS12355	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SPICA_RS12365	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SPICA_RS12365	COG0140	phosphoribosyl-ATP diphosphatase activity
SPICA_RS12370	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SPICA_RS12375	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SPICA_RS12400	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
SPICA_RS12440	COG0395	ABC-type sugar transport system, permease component
SPICA_RS12445	COG4209	transmembrane transport
SPICA_RS12450	COG1653	transport
SPICA_RS12530	COG1940	carbohydrate kinase activity
SPICA_RS12530	COG1846	Transcriptional regulator
SPICA_RS12535	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SPICA_RS12540	COG0363	glucosamine-6-phosphate deaminase activity
SPICA_RS12545	COG2239	Acts as a magnesium transporter
SPICA_RS12550	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPICA_RS12555	COG1993	acr, cog1993
SPICA_RS12580	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SPICA_RS12590	COG1013	pyruvate-flavodoxin oxidoreductase activity
SPICA_RS12590	COG0674	pyruvate-flavodoxin oxidoreductase activity
SPICA_RS12590	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SPICA_RS12590	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
SPICA_RS12600	COG0438	transferase activity, transferring glycosyl groups
SPICA_RS12605	COG2610	gluconate transmembrane transporter activity
SPICA_RS12610	COG3956	TIGRFAM MazG family protein
SPICA_RS12615	COG0193	aminoacyl-tRNA hydrolase activity
SPICA_RS12620	COG3345	alpha-galactosidase
SPICA_RS12625	COG1227	inorganic diphosphatase activity
SPICA_RS12625	COG0517	IMP dehydrogenase activity
SPICA_RS12640	COG0740	serine-type endopeptidase activity
SPICA_RS12650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPICA_RS12660	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SPICA_RS12665	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SPICA_RS12695	COG0765	amino acid transport
SPICA_RS12700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPICA_RS12715	COG0778	Nitroreductase
SPICA_RS12725	COG0728	peptidoglycan biosynthetic process
SPICA_RS12730	COG0584	glycerophosphoryl diester phosphodiesterase
SPICA_RS12740	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SPICA_RS12745	COG0569	domain protein
SPICA_RS12750	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPICA_RS12755	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
SPICA_RS12760	COG2217	Heavy metal translocating P-type atpase
SPICA_RS12765	COG2608	mercury ion transmembrane transporter activity
SPICA_RS12815	COG1012	belongs to the aldehyde dehydrogenase family
SPICA_RS12820	COG2252	PERMEase
SPICA_RS12830	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SPICA_RS12840	COG0745	RESPONSE REGULATOR receiver
SPICA_RS12855	COG4608	Belongs to the ABC transporter superfamily
SPICA_RS12860	COG0444	Belongs to the ABC transporter superfamily
SPICA_RS12865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPICA_RS12870	COG0601	transmembrane transport
SPICA_RS12875	COG4166	transmembrane transport
SPICA_RS12960	COG0543	2 iron, 2 sulfur cluster binding
SPICA_RS12965	COG0167	dihydroorotate dehydrogenase activity
SPICA_RS13025	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SPICA_RS13030	COG0724	RNA recognition motif
SPICA_RS13065	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SPICA_RS13070	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SPICA_RS13075	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SPICA_RS13080	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SPICA_RS13085	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPICA_RS13090	COG5000	phosphorelay sensor kinase activity
SPICA_RS13095	COG2204	response regulator
SPICA_RS13110	COG1252	NADH dehydrogenase
SPICA_RS13130	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SPICA_RS13135	COG0248	Ppx GppA phosphatase
SPICA_RS13145	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SPICA_RS13185	COG4771	TonB-dependent receptor
SPICA_RS13195	COG0765	amino acid transport
SPICA_RS13210	COG0745	RESPONSE REGULATOR receiver
SPICA_RS13215	COG2205	protein histidine kinase activity
SPICA_RS13220	COG1131	(ABC) transporter
SPICA_RS13240	COG0724	RNA recognition motif
SPICA_RS13245	COG0840	transmembrane signaling receptor activity
SPICA_RS13260	COG1640	4-alpha-glucanotransferase
SPICA_RS13275	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SPICA_RS13285	COG0765	amino acid transport
SPICA_RS13295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPICA_RS13300	COG0640	Transcriptional regulator
SPICA_RS13310	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SPICA_RS13315	COG1609	Transcriptional regulator
SPICA_RS13320	COG0519	Catalyzes the synthesis of GMP from XMP
SPICA_RS13335	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SPICA_RS13340	COG2207	Transcriptional regulator
SPICA_RS13340	COG4753	response regulator
SPICA_RS13345	COG3275	phosphorelay sensor kinase activity
SPICA_RS13380	COG0280	phosphate acetyltransferase
SPICA_RS13385	COG3426	butyrate kinase activity
SPICA_RS13400	COG2195	Cleaves the N-terminal amino acid of tripeptides
SPICA_RS13420	COG1131	(ABC) transporter
SPICA_RS13430	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SPICA_RS13435	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SPICA_RS13440	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SPICA_RS13450	COG0488	(ABC) transporter
SPICA_RS13465	COG4603	Belongs to the binding-protein-dependent transport system permease family
SPICA_RS13470	COG3845	ABC transporter
SPICA_RS13475	COG1744	ABC transporter substrate-binding protein PnrA-like
SPICA_RS13505	COG2337	Toxic component of a toxin-antitoxin (TA) module
SPICA_RS13520	COG0564	pseudouridine synthase activity
SPICA_RS13530	COG0501	Belongs to the peptidase M48B family
SPICA_RS13535	COG0028	Belongs to the TPP enzyme family
SPICA_RS13540	COG0129	dihydroxy-acid dehydratase activity
SPICA_RS13545	COG0473	3-isopropylmalate dehydrogenase activity
SPICA_RS13550	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SPICA_RS13555	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SPICA_RS13560	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SPICA_RS13565	COG0440	acetolactate synthase activity
SPICA_RS13570	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SPICA_RS13595	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
SPICA_RS13610	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SPICA_RS13610	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SPICA_RS13615	COG0129	dihydroxy-acid dehydratase activity
SPICA_RS13620	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SPICA_RS13625	COG0066	3-isopropylmalate dehydratase activity
SPICA_RS13630	COG0028	Belongs to the TPP enzyme family
SPICA_RS13635	COG0440	acetolactate synthase activity
SPICA_RS13640	COG0477	Major facilitator Superfamily
SPICA_RS13655	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SPICA_RS13665	COG0732	type I restriction modification DNA specificity domain
SPICA_RS13675	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SPICA_RS13685	COG1598	PFAM Uncharacterised protein family UPF0150
SPICA_RS13690	COG5002	protein histidine kinase activity
SPICA_RS13695	COG0009	L-threonylcarbamoyladenylate synthase
SPICA_RS13705	COG0598	Magnesium transport protein CorA
SPICA_RS13710	COG5297	Belongs to the glycosyl hydrolase family 6
SPICA_RS13710	COG3250	beta-galactosidase activity
SPICA_RS13725	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SPICA_RS13735	COG0495	leucyl-tRNA aminoacylation
SPICA_RS13740	COG0662	Cupin 2, conserved barrel domain protein
SPICA_RS13750	COG0438	transferase activity, transferring glycosyl groups
SPICA_RS13760	COG0006	proline dipeptidase activity
SPICA_RS13775	COG0446	pyridine nucleotide-disulphide oxidoreductase
SPICA_RS13780	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SPICA_RS13795	COG1639	'signal transduction protein
SPICA_RS13810	COG0322	excinuclease ABC activity
SPICA_RS13835	COG1876	peptidase activity
SPICA_RS13855	COG0572	uridine kinase
SPICA_RS13860	COG0733	neurotransmitter:sodium symporter activity
SPICA_RS13865	COG0484	heat shock protein binding
SPICA_RS13875	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SPICA_RS13885	COG1968	undecaprenyl-diphosphatase activity
SPICA_RS13890	COG1187	pseudouridine synthase activity
SPICA_RS13900	COG1070	Carbohydrate kinase
SPICA_RS13910	COG0745	RESPONSE REGULATOR receiver
SPICA_RS13915	COG3920	Histidine kinase
SPICA_RS13925	COG1127	ABC transporter
SPICA_RS13945	COG2884	Cell division ATP-binding protein ftsE
SPICA_RS13960	COG1692	metallophosphoesterase
SPICA_RS13965	COG1418	mRNA catabolic process
SPICA_RS13970	COG1137	ATPase activity
SPICA_RS14000	COG2201	protein-glutamate methylesterase activity
SPICA_RS14010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPICA_RS14020	COG1692	metallophosphoesterase
SPICA_RS14065	COG0318	PFAM AMP-dependent synthetase and ligase
SPICA_RS14085	COG0517	IMP dehydrogenase activity
SPICA_RS14085	COG0516	GMP reductase activity
SPICA_RS14090	COG0561	phosphatase activity
SPICA_RS14105	COG1192	Involved in chromosome partitioning
SPICA_RS14110	COG1475	DNA binding
SPICA_RS14120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPICA_RS14130	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
SPICA_RS14135	COG1215	transferase activity, transferring glycosyl groups
SPICA_RS14180	COG4120	Belongs to the binding-protein-dependent transport system permease family
SPICA_RS14190	COG0281	malic enzyme
SPICA_RS14205	COG3775	system Galactitol-specific IIC component
SPICA_RS14210	COG0442	prolyl-tRNA aminoacylation
SPICA_RS14220	COG0058	SHG alpha-glucan phosphorylase activity
SPICA_RS14230	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SPICA_RS14235	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SPICA_RS14240	COG4214	carbohydrate transport
SPICA_RS14245	COG1129	ABC transporter
SPICA_RS14250	COG4213	ABC transporter substrate-binding protein
SPICA_RS14255	COG1349	DNA-binding transcription factor activity
SPICA_RS14260	COG1129	ABC transporter
SPICA_RS14270	COG2160	L-arabinose isomerase activity
SPICA_RS14280	COG0534	Mate efflux family protein
SPICA_RS14285	COG2382	esterase
SPICA_RS14285	COG3507	Belongs to the glycosyl hydrolase 43 family
SPICA_RS14285	COG3693	PFAM glycoside hydrolase, family 10
SPICA_RS14305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPICA_RS14310	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SPICA_RS14315	COG2084	Dehydrogenase
SPICA_RS14330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SPICA_RS14335	COG1410	methionine synthase
SPICA_RS14335	COG0646	methionine synthase
SPICA_RS14355	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
SPICA_RS14360	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SPICA_RS14390	COG0569	domain protein
SPICA_RS14395	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPICA_RS14405	COG0395	ABC-type sugar transport system, permease component
SPICA_RS14410	COG1175	transmembrane transport
SPICA_RS14415	COG1653	transport
SPICA_RS14425	COG1063	alcohol dehydrogenase
SPICA_RS14435	COG0714	Associated with various cellular activities
SPICA_RS14450	COG3339	Conserved Protein
SPICA_RS14460	COG1022	Amp-dependent synthetase and ligase
SPICA_RS14465	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SPICA_RS14470	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SPICA_RS14510	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPICA_RS14515	COG0187	DNA topoisomerase II activity
SPICA_RS14575	COG0134	indole-3-glycerol-phosphate synthase activity
SPICA_RS14580	COG0484	heat shock protein binding
SPICA_RS14595	COG0719	Fe-S assembly protein
SPICA_RS14640	COG1525	nuclease
SPICA_RS14645	COG1120	ATPase activity
SPICA_RS14660	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SPICA_RS14665	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SPICA_RS14685	COG1342	Belongs to the UPF0251 family
SPICA_RS14690	COG1309	transcriptional regulator
SPICA_RS14745	COG3330	Domain of unknown function (DUF4912)
SPICA_RS14795	COG3359	exonuclease
SPICA_RS14800	COG4657	Part of a membrane complex involved in electron transport
SPICA_RS14890	COG3290	protein histidine kinase activity
SPICA_RS14890	COG0840	transmembrane signaling receptor activity
SPICA_RS14900	COG0584	glycerophosphoryl diester phosphodiesterase
SPICA_RS14915	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPICA_RS14930	COG0739	heme binding
SPICA_RS14935	COG0840	transmembrane signaling receptor activity
SPICA_RS14950	COG3437	response regulator, receiver
SPICA_RS14955	COG4585	Histidine kinase
SPICA_RS15000	COG0840	transmembrane signaling receptor activity
SPICA_RS15030	COG2189	Belongs to the N(4) N(6)-methyltransferase family
SPICA_RS15035	COG2189	Belongs to the N(4) N(6)-methyltransferase family
SPICA_RS15040	COG3421	Type III restriction
SPICA_RS15045	COG3421	Type III restriction
SPICA_RS15080	COG2062	phosphohistidine phosphatase, SixA
SPICA_RS15085	COG2203	Gaf domain
SPICA_RS15085	COG2199	diguanylate cyclase activity
SPICA_RS15090	COG0791	NLP P60 protein