locus-tag	class	description
HGJ18_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HGJ18_RS00015	COG0587	DNA-directed DNA polymerase activity
HGJ18_RS00040	COG0840	transmembrane signaling receptor activity
HGJ18_RS00045	COG1132	(ABC) transporter
HGJ18_RS00050	COG1132	(ABC) transporter
HGJ18_RS00110	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HGJ18_RS00125	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HGJ18_RS00130	COG1360	Flagellar Motor Protein
HGJ18_RS00135	COG1580	Controls the rotational direction of flagella during chemotaxis
HGJ18_RS00140	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HGJ18_RS00145	COG1776	CheC inhibitor of MCP methylation
HGJ18_RS00145	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HGJ18_RS00155	COG1338	Plays a role in the flagellum-specific transport system
HGJ18_RS00170	COG4166	transmembrane transport
HGJ18_RS00175	COG2423	ornithine cyclodeaminase activity
HGJ18_RS00180	COG0739	heme binding
HGJ18_RS00185	COG4545	Glutaredoxin-related protein
HGJ18_RS00200	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HGJ18_RS00225	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HGJ18_RS00235	COG0732	type I restriction modification DNA specificity domain
HGJ18_RS00245	COG4974	Belongs to the 'phage' integrase family
HGJ18_RS00255	COG0732	type I restriction modification DNA specificity domain
HGJ18_RS00265	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HGJ18_RS00265	COG3116	cell division
HGJ18_RS00270	COG0084	hydrolase, TatD family'
HGJ18_RS00285	COG2199	diguanylate cyclase activity
HGJ18_RS00285	COG2203	Gaf domain
HGJ18_RS00295	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HGJ18_RS00320	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HGJ18_RS00325	COG2239	Acts as a magnesium transporter
HGJ18_RS00335	COG0546	phosphoglycolate phosphatase activity
HGJ18_RS00340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HGJ18_RS00445	COG2211	Major facilitator Superfamily
HGJ18_RS00475	COG0396	ATPase activity
HGJ18_RS00480	COG0719	Fe-S assembly protein
HGJ18_RS00495	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HGJ18_RS00500	COG3549	Plasmid maintenance system killer
HGJ18_RS00505	COG3093	addiction module antidote protein HigA
HGJ18_RS00535	COG0425	Belongs to the sulfur carrier protein TusA family
HGJ18_RS00545	COG1104	cysteine desulfurase activity
HGJ18_RS00550	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HGJ18_RS00555	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HGJ18_RS00560	COG1862	Preprotein translocase
HGJ18_RS00565	COG0629	single-stranded DNA binding
HGJ18_RS00570	COG1028	Short-chain dehydrogenase reductase Sdr
HGJ18_RS00575	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HGJ18_RS00580	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HGJ18_RS00595	COG0482	sulfurtransferase activity
HGJ18_RS00605	COG0351	phosphomethylpyrimidine kinase
HGJ18_RS00610	COG1131	(ABC) transporter
HGJ18_RS00650	COG1131	(ABC) transporter
HGJ18_RS00670	COG0330	HflC and HflK could
HGJ18_RS00745	COG2274	protein secretion by the type I secretion system
HGJ18_RS00755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGJ18_RS00780	COG0793	Belongs to the peptidase S41A family
HGJ18_RS00785	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HGJ18_RS00835	COG3118	belongs to the thioredoxin family
HGJ18_RS00845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HGJ18_RS00860	COG1757	Na H antiporter
HGJ18_RS00870	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HGJ18_RS00875	COG0051	transcription antitermination factor activity, RNA binding
HGJ18_RS00880	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HGJ18_RS00885	COG0088	Forms part of the polypeptide exit tunnel
HGJ18_RS00890	COG0089	rRNA binding
HGJ18_RS00895	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HGJ18_RS00900	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HGJ18_RS00905	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HGJ18_RS00910	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HGJ18_RS00915	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HGJ18_RS00920	COG0255	Belongs to the universal ribosomal protein uL29 family
HGJ18_RS00925	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HGJ18_RS00930	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HGJ18_RS00935	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HGJ18_RS00940	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HGJ18_RS00945	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HGJ18_RS00950	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HGJ18_RS00955	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HGJ18_RS00960	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HGJ18_RS00965	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HGJ18_RS00970	COG1841	ribosomal large subunit assembly
HGJ18_RS00975	COG0200	Binds to the 23S rRNA
HGJ18_RS00985	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HGJ18_RS00990	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HGJ18_RS00995	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HGJ18_RS01000	COG0202	RNA polymerase activity
HGJ18_RS01005	COG0203	ribosomal protein L17
HGJ18_RS01025	COG1254	Belongs to the acylphosphatase family
HGJ18_RS01045	COG2226	methyltransferase
HGJ18_RS01050	COG1959	2 iron, 2 sulfur cluster binding
HGJ18_RS01055	COG2910	NAD(P)H-binding
HGJ18_RS01070	COG1401	restriction endodeoxyribonuclease activity
HGJ18_RS01095	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HGJ18_RS01190	COG2274	protein secretion by the type I secretion system
HGJ18_RS01195	COG1132	(ABC) transporter
HGJ18_RS01200	COG1132	(ABC) transporter
HGJ18_RS01225	COG1132	(ABC) transporter
HGJ18_RS01230	COG1129	ABC transporter
HGJ18_RS01245	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HGJ18_RS01255	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HGJ18_RS01260	COG3422	double-strand break repair
HGJ18_RS01265	COG0445	tRNA wobble uridine modification
HGJ18_RS01270	COG1362	aminopeptidase activity
HGJ18_RS01275	COG4657	Part of a membrane complex involved in electron transport
HGJ18_RS01280	COG4660	Part of a membrane complex involved in electron transport
HGJ18_RS01285	COG4659	FMN binding
HGJ18_RS01290	COG4658	electron transport chain
HGJ18_RS01295	COG4656	Part of a membrane complex involved in electron transport
HGJ18_RS01300	COG1054	Belongs to the UPF0176 family
HGJ18_RS01310	COG2304	oxidoreductase activity
HGJ18_RS01325	COG0574	Belongs to the PEP-utilizing enzyme family
HGJ18_RS01325	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HGJ18_RS01335	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HGJ18_RS01360	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HGJ18_RS01370	COG2137	regulation of response to DNA damage stimulus
HGJ18_RS01375	COG2197	response regulator
HGJ18_RS01400	COG1187	pseudouridine synthase activity
HGJ18_RS01405	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HGJ18_RS01420	COG1285	pathogenesis
HGJ18_RS01425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HGJ18_RS01460	COG0737	Belongs to the 5'-nucleotidase family
HGJ18_RS01465	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HGJ18_RS01470	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HGJ18_RS01475	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HGJ18_RS01495	COG0228	four-way junction DNA binding
HGJ18_RS01500	COG1837	Belongs to the UPF0109 family
HGJ18_RS01505	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HGJ18_RS01510	COG0336	Belongs to the RNA methyltransferase TrmD family
HGJ18_RS01515	COG0335	large ribosomal subunit rRNA binding
HGJ18_RS01535	COG0210	DNA helicase
HGJ18_RS01545	COG1129	ABC transporter
HGJ18_RS01555	COG2375	cellular response to nickel ion
HGJ18_RS01555	COG1132	(ABC) transporter
HGJ18_RS01560	COG1132	(ABC) transporter
HGJ18_RS01570	COG1132	(ABC) transporter
HGJ18_RS01575	COG1132	(ABC) transporter
HGJ18_RS01580	COG2195	Cleaves the N-terminal amino acid of tripeptides
HGJ18_RS01595	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HGJ18_RS01600	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HGJ18_RS01605	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HGJ18_RS01610	COG0534	Mate efflux family protein
HGJ18_RS01620	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HGJ18_RS01625	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HGJ18_RS01630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HGJ18_RS01635	COG0116	Belongs to the methyltransferase superfamily
HGJ18_RS01640	COG3735	TraB family
HGJ18_RS01650	COG0791	NLP P60 protein
HGJ18_RS01655	COG0318	PFAM AMP-dependent synthetase and ligase
HGJ18_RS01675	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HGJ18_RS01685	COG0148	phosphopyruvate hydratase activity
HGJ18_RS01705	COG1744	ABC transporter substrate-binding protein PnrA-like
HGJ18_RS01710	COG3845	ABC transporter
HGJ18_RS01715	COG4603	Belongs to the binding-protein-dependent transport system permease family
HGJ18_RS01720	COG1079	Belongs to the binding-protein-dependent transport system permease family
HGJ18_RS01745	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HGJ18_RS01760	COG1704	LemA family
HGJ18_RS01765	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HGJ18_RS01770	COG0584	glycerophosphoryl diester phosphodiesterase
HGJ18_RS01775	COG1752	Esterase of the alpha-beta hydrolase superfamily
HGJ18_RS01780	COG5341	Protein conserved in bacteria
HGJ18_RS01785	COG2089	acid synthase
HGJ18_RS01790	COG0484	heat shock protein binding
HGJ18_RS01800	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HGJ18_RS01810	COG1692	metallophosphoesterase
HGJ18_RS01815	COG0084	hydrolase, TatD family'
HGJ18_RS01825	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HGJ18_RS01850	COG0018	arginyl-trna synthetase
HGJ18_RS01855	COG1040	competence protein
HGJ18_RS01860	COG2003	Belongs to the UPF0758 family
HGJ18_RS01865	COG1686	Belongs to the peptidase S11 family
HGJ18_RS01870	COG0017	Asparaginyl-tRNA synthetase
HGJ18_RS01885	COG4166	transmembrane transport
HGJ18_RS01890	COG4166	transmembrane transport
HGJ18_RS01895	COG4174	ABC transporter (Permease)
HGJ18_RS01900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGJ18_RS01905	COG4166	transmembrane transport
HGJ18_RS01910	COG0444	Belongs to the ABC transporter superfamily
HGJ18_RS01915	COG4608	Belongs to the ABC transporter superfamily
HGJ18_RS01920	COG4166	transmembrane transport
HGJ18_RS01925	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HGJ18_RS01935	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HGJ18_RS01960	COG2116	formate transmembrane transporter activity
HGJ18_RS01965	COG2084	Dehydrogenase
HGJ18_RS01980	COG4786	Flagellar basal body rod
HGJ18_RS01990	COG3951	Flagellar rod assembly protein muramidase FlgJ
HGJ18_RS02000	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HGJ18_RS02010	COG2183	response to ionizing radiation
HGJ18_RS02025	COG1067	ATP-dependent peptidase activity
HGJ18_RS02040	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HGJ18_RS02040	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HGJ18_RS02060	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HGJ18_RS02070	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HGJ18_RS02075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HGJ18_RS02080	COG0571	ribonuclease III activity
HGJ18_RS02085	COG0071	Belongs to the small heat shock protein (HSP20) family
HGJ18_RS02100	COG0617	tRNA 3'-terminal CCA addition
HGJ18_RS02105	COG0598	Magnesium transport protein CorA
HGJ18_RS02115	COG0196	riboflavin kinase activity
HGJ18_RS02120	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HGJ18_RS02125	COG1185	polyribonucleotide nucleotidyltransferase activity
HGJ18_RS02130	COG0756	dUTP diphosphatase activity
HGJ18_RS02145	COG2832	Protein of unknown function (DUF454)
HGJ18_RS02155	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HGJ18_RS02160	COG0049	tRNA binding
HGJ18_RS02165	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HGJ18_RS02190	COG0840	transmembrane signaling receptor activity
HGJ18_RS02195	COG0534	Mate efflux family protein
HGJ18_RS02225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HGJ18_RS02225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HGJ18_RS02235	COG4608	Belongs to the ABC transporter superfamily
HGJ18_RS02240	COG0444	Belongs to the ABC transporter superfamily
HGJ18_RS02245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGJ18_RS02250	COG0601	transmembrane transport
HGJ18_RS02270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGJ18_RS02275	COG0444	Belongs to the ABC transporter superfamily
HGJ18_RS02280	COG4608	Belongs to the ABC transporter superfamily
HGJ18_RS02285	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HGJ18_RS02285	COG0426	domain, Protein
HGJ18_RS02295	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HGJ18_RS02300	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HGJ18_RS02315	COG0564	pseudouridine synthase activity
HGJ18_RS02320	COG0285	dihydrofolate synthase activity
HGJ18_RS02330	COG1561	YicC-like family, N-terminal region
HGJ18_RS02335	COG1102	Psort location Cytoplasmic, score
HGJ18_RS02340	COG3706	GGDEF domain
HGJ18_RS02350	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HGJ18_RS02365	COG3330	Domain of unknown function (DUF4912)
HGJ18_RS02375	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HGJ18_RS02380	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HGJ18_RS02400	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HGJ18_RS02405	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HGJ18_RS02410	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HGJ18_RS02420	COG0779	Required for maturation of 30S ribosomal subunits
HGJ18_RS02440	COG0563	adenylate kinase activity
HGJ18_RS02445	COG3033	Beta-eliminating lyase
HGJ18_RS02465	COG1366	Belongs to the anti-sigma-factor antagonist family
HGJ18_RS02505	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HGJ18_RS02510	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HGJ18_RS02525	COG0459	protein refolding
HGJ18_RS02545	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HGJ18_RS02555	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HGJ18_RS02595	COG1505	serine-type exopeptidase activity
HGJ18_RS02600	COG2001	Belongs to the MraZ family
HGJ18_RS02605	COG0275	rRNA processing
HGJ18_RS02615	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HGJ18_RS02620	COG0772	Belongs to the SEDS family
HGJ18_RS02635	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HGJ18_RS02640	COG4974	Belongs to the 'phage' integrase family
HGJ18_RS02650	COG0758	DNA mediated transformation
HGJ18_RS02655	COG0551	DNA topoisomerase type I activity
HGJ18_RS02655	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HGJ18_RS02660	COG4974	Belongs to the 'phage' integrase family
HGJ18_RS02665	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HGJ18_RS02670	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HGJ18_RS02685	COG1677	Flagellar hook-basal body complex protein FliE
HGJ18_RS02690	COG1766	The M ring may be actively involved in energy transduction
HGJ18_RS02700	COG1317	bacterial-type flagellum organization
HGJ18_RS02705	COG1157	protein secretion by the type III secretion system
HGJ18_RS02730	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HGJ18_RS02735	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HGJ18_RS02740	COG1121	(ABC) transporter
HGJ18_RS02745	COG0803	Belongs to the bacterial solute-binding protein 9 family
HGJ18_RS02760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HGJ18_RS02775	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HGJ18_RS02785	COG0149	triose-phosphate isomerase activity
HGJ18_RS02800	COG1702	phosphate starvation-inducible protein PhoH
HGJ18_RS02805	COG1480	7TM receptor with intracellular HD hydrolase
HGJ18_RS02810	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HGJ18_RS02860	COG1193	negative regulation of DNA recombination
HGJ18_RS02885	COG1115	amino acid carrier protein
HGJ18_RS02890	COG4750	Nucleotidyl transferase
HGJ18_RS02895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HGJ18_RS02905	COG3118	belongs to the thioredoxin family
HGJ18_RS02910	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HGJ18_RS02915	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HGJ18_RS02945	COG4475	Protein of unknown function (DUF436)
HGJ18_RS02950	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HGJ18_RS02970	COG4245	von Willebrand factor, type A
HGJ18_RS03025	COG0840	transmembrane signaling receptor activity
HGJ18_RS03030	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HGJ18_RS03110	COG0312	modulator of DNA gyrase
HGJ18_RS03115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HGJ18_RS03120	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HGJ18_RS03130	COG1388	LysM domain
HGJ18_RS03130	COG3942	CHAP domain
HGJ18_RS03150	COG0497	DNA recombination
HGJ18_RS03175	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HGJ18_RS03180	COG0312	modulator of DNA gyrase
HGJ18_RS03190	COG4988	ABC transporter
HGJ18_RS03195	COG0433	COG0433 Predicted ATPase
HGJ18_RS03205	COG0768	penicillin binding
HGJ18_RS03210	COG2604	Protein of unknown function DUF115
HGJ18_RS03235	COG1739	Uncharacterized protein family UPF0029
HGJ18_RS03265	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HGJ18_RS03275	COG0330	HflC and HflK could
HGJ18_RS03280	COG0330	HflC and HflK could
HGJ18_RS03305	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HGJ18_RS03310	COG2088	sporulation resulting in formation of a cellular spore
HGJ18_RS03320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HGJ18_RS03325	COG0037	tRNA processing
HGJ18_RS03330	COG0457	Tetratricopeptide repeat
HGJ18_RS03335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HGJ18_RS03340	COG0358	DNA primase activity
HGJ18_RS03345	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HGJ18_RS03365	COG1077	Cell shape determining protein MreB Mrl
HGJ18_RS03380	COG0768	penicillin binding
HGJ18_RS03385	COG0772	Belongs to the SEDS family
HGJ18_RS03410	COG2252	PERMEase
HGJ18_RS03420	COG0525	valine-tRNA ligase activity
HGJ18_RS03430	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HGJ18_RS03435	COG0346	lactoylglutathione lyase activity
HGJ18_RS03440	COG0556	nucleotide-excision repair
HGJ18_RS03445	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HGJ18_RS03445	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HGJ18_RS03450	COG0557	exoribonuclease II activity
HGJ18_RS03485	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HGJ18_RS03520	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
HGJ18_RS03525	COG0640	Transcriptional regulator
HGJ18_RS03530	COG2217	Heavy metal translocating P-type atpase
HGJ18_RS03540	COG0564	pseudouridine synthase activity
HGJ18_RS03555	COG4656	Part of a membrane complex involved in electron transport
HGJ18_RS03560	COG4658	electron transport chain
HGJ18_RS03595	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HGJ18_RS03600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HGJ18_RS03600	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HGJ18_RS03610	COG0488	(ABC) transporter
HGJ18_RS03620	COG0047	phosphoribosylformylglycinamidine synthase activity
HGJ18_RS03630	COG1078	dGTPase activity
HGJ18_RS03655	COG0475	glutathione-regulated potassium exporter activity
HGJ18_RS03685	COG0463	Glycosyl transferase, family 2
HGJ18_RS03700	COG1368	sulfuric ester hydrolase activity
HGJ18_RS03720	COG1086	Polysaccharide biosynthesis protein
HGJ18_RS03725	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HGJ18_RS03730	COG0562	UDP-galactopyranose mutase
HGJ18_RS03745	COG1083	cytidylyl-transferase
HGJ18_RS03750	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HGJ18_RS03770	COG2089	acid synthase
HGJ18_RS03780	COG1215	transferase activity, transferring glycosyl groups
HGJ18_RS03790	COG0463	Glycosyl transferase, family 2
HGJ18_RS03790	COG1216	Glycosyl transferase, family 2
HGJ18_RS03815	COG0438	transferase activity, transferring glycosyl groups
HGJ18_RS03825	COG0463	Glycosyl transferase, family 2
HGJ18_RS03860	COG0297	glycogen (starch) synthase activity
HGJ18_RS03865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HGJ18_RS03875	COG1088	dTDP-glucose 4,6-dehydratase activity
HGJ18_RS03880	COG0124	histidyl-tRNA synthetase
HGJ18_RS03890	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HGJ18_RS03905	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HGJ18_RS03915	COG1162	GTPase activity
HGJ18_RS03920	COG1193	negative regulation of DNA recombination
HGJ18_RS03935	COG2211	Major facilitator Superfamily
HGJ18_RS03935	COG2190	(PTS) system
HGJ18_RS03975	COG0009	L-threonylcarbamoyladenylate synthase
HGJ18_RS03985	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HGJ18_RS03995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HGJ18_RS04000	COG2770	Histidine kinase
HGJ18_RS04000	COG3437	response regulator, receiver
HGJ18_RS04010	COG0802	atpase or kinase
HGJ18_RS04025	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HGJ18_RS04025	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HGJ18_RS04035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HGJ18_RS04040	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HGJ18_RS04075	COG0217	transcriptional regulatory protein
HGJ18_RS04080	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HGJ18_RS04095	COG0643	Histidine kinase
HGJ18_RS04095	COG2198	Histidine kinase
HGJ18_RS04100	COG0835	chemotaxis
HGJ18_RS04110	COG2201	protein-glutamate methylesterase activity
HGJ18_RS04120	COG1196	nuclear chromosome segregation
HGJ18_RS04130	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HGJ18_RS04135	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HGJ18_RS04145	COG0574	Belongs to the PEP-utilizing enzyme family
HGJ18_RS04145	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HGJ18_RS04160	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HGJ18_RS04165	COG0254	rRNA binding
HGJ18_RS04175	COG1760	l-serine dehydratase
HGJ18_RS04180	COG1760	l-serine dehydratase
HGJ18_RS04190	COG1136	(ABC) transporter
HGJ18_RS04195	COG0672	)-iron permease
HGJ18_RS04200	COG3470	protein probably involved in high-affinity Fe2 transport
HGJ18_RS04215	COG0577	efflux transmembrane transporter activity
HGJ18_RS04220	COG1136	(ABC) transporter
HGJ18_RS04250	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HGJ18_RS04270	COG1692	metallophosphoesterase
HGJ18_RS04280	COG0142	geranyltranstransferase activity
HGJ18_RS04285	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HGJ18_RS04305	COG0727	PFAM Uncharacterised protein family (UPF0153)
HGJ18_RS04310	COG1234	tRNA 3'-trailer cleavage
HGJ18_RS04320	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HGJ18_RS04340	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HGJ18_RS04345	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HGJ18_RS04350	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HGJ18_RS04355	COG0205	6-phosphofructokinase activity
HGJ18_RS04360	COG0095	Lipoate-protein ligase
HGJ18_RS04395	COG4115	mRNA cleavage
HGJ18_RS04405	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HGJ18_RS04410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HGJ18_RS04435	COG2982	Protein involved in outer membrane biogenesis
HGJ18_RS04440	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
HGJ18_RS04445	COG0297	glycogen (starch) synthase activity
HGJ18_RS04465	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HGJ18_RS04475	COG0835	chemotaxis
HGJ18_RS04485	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HGJ18_RS04490	COG0488	(ABC) transporter
HGJ18_RS04500	COG0493	'glutamate synthase
HGJ18_RS04500	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HGJ18_RS04505	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HGJ18_RS04520	COG1129	ABC transporter
HGJ18_RS04525	COG1132	(ABC) transporter
HGJ18_RS04530	COG1132	(ABC) transporter
HGJ18_RS04530	COG2375	cellular response to nickel ion
HGJ18_RS04535	COG1309	transcriptional regulator
HGJ18_RS04555	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HGJ18_RS04575	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HGJ18_RS04595	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HGJ18_RS04600	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HGJ18_RS04605	COG0509	glycine decarboxylation via glycine cleavage system
HGJ18_RS04610	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HGJ18_RS04620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HGJ18_RS04655	COG3052	prosthetic group binding
HGJ18_RS04660	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HGJ18_RS04660	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HGJ18_RS04660	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HGJ18_RS04665	COG0237	dephospho-CoA kinase activity
HGJ18_RS04675	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HGJ18_RS04680	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HGJ18_RS04695	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HGJ18_RS04720	COG1122	ATPase activity
HGJ18_RS04725	COG1268	BioY protein
HGJ18_RS04730	COG1132	(ABC) transporter
HGJ18_RS04735	COG1132	(ABC) transporter
HGJ18_RS04755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HGJ18_RS04760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HGJ18_RS04765	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HGJ18_RS04775	COG0305	Participates in initiation and elongation during chromosome replication
HGJ18_RS04795	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HGJ18_RS04805	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HGJ18_RS04825	COG0544	peptidyl-prolyl cis-trans isomerase activity
HGJ18_RS04830	COG0740	serine-type endopeptidase activity
HGJ18_RS04835	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HGJ18_RS04840	COG0359	binds to the 23S rRNA
HGJ18_RS04845	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HGJ18_RS04850	COG0629	single-stranded DNA binding
HGJ18_RS04855	COG0360	Binds together with S18 to 16S ribosomal RNA
HGJ18_RS04865	COG1269	ATP hydrolysis coupled proton transport
HGJ18_RS04870	COG1394	ATPase activity, coupled to movement of substances
HGJ18_RS04875	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HGJ18_RS04880	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HGJ18_RS04885	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HGJ18_RS04890	COG2203	Gaf domain
HGJ18_RS04890	COG3706	GGDEF domain
HGJ18_RS04890	COG4251	negative regulation of phosphorylation
HGJ18_RS04890	COG5001	Diguanylate cyclase
HGJ18_RS04895	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HGJ18_RS04900	COG0457	Tetratricopeptide repeat
HGJ18_RS04910	COG1131	(ABC) transporter
HGJ18_RS04930	COG0588	phosphoglycerate mutase activity
HGJ18_RS04955	COG1058	Belongs to the CinA family
HGJ18_RS04955	COG1546	Belongs to the CinA family
HGJ18_RS04965	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HGJ18_RS04970	COG0776	regulation of translation
HGJ18_RS04975	COG0268	Binds directly to 16S ribosomal RNA
HGJ18_RS04995	COG0860	N-Acetylmuramoyl-L-alanine amidase
HGJ18_RS05000	COG0126	phosphoglycerate kinase activity
HGJ18_RS05010	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HGJ18_RS05015	COG0519	Catalyzes the synthesis of GMP from XMP
HGJ18_RS05020	COG1846	Transcriptional regulator
HGJ18_RS05055	COG0617	tRNA 3'-terminal CCA addition
HGJ18_RS05075	COG3250	beta-galactosidase activity
HGJ18_RS05085	COG0484	heat shock protein binding
HGJ18_RS05090	COG0024	Methionine aminopeptidase
HGJ18_RS05095	COG0708	Exodeoxyribonuclease III
HGJ18_RS05110	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HGJ18_RS05120	COG0739	heme binding
HGJ18_RS05375	COG2059	Chromate
HGJ18_RS05380	COG0799	negative regulation of ribosome biogenesis
HGJ18_RS05395	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HGJ18_RS05400	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HGJ18_RS05410	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HGJ18_RS05415	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HGJ18_RS05420	COG2033	superoxide reductase activity
HGJ18_RS05495	COG0484	heat shock protein binding
HGJ18_RS05635	COG3093	addiction module antidote protein HigA
HGJ18_RS05760	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HGJ18_RS05790	COG1418	mRNA catabolic process
HGJ18_RS05805	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HGJ18_RS05840	COG1196	nuclear chromosome segregation
HGJ18_RS06010	COG0561	phosphatase activity
HGJ18_RS06105	COG0577	efflux transmembrane transporter activity
HGJ18_RS06105	COG1136	(ABC) transporter
HGJ18_RS06110	COG1136	(ABC) transporter
HGJ18_RS06130	COG2161	toxin-antitoxin pair type II binding
HGJ18_RS06150	COG2056	Na+-H+ antiporter family
HGJ18_RS06185	COG0632	four-way junction helicase activity
HGJ18_RS06190	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HGJ18_RS06225	COG0793	Belongs to the peptidase S41A family
HGJ18_RS06235	COG0488	(ABC) transporter
HGJ18_RS06250	COG2723	6-phospho-beta-galactosidase activity
HGJ18_RS06265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HGJ18_RS06280	COG1114	Component of the transport system for branched-chain amino acids
HGJ18_RS06290	COG0481	GTPase activity
HGJ18_RS06295	COG2878	Part of a membrane complex involved in electron transport
HGJ18_RS06300	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HGJ18_RS06305	COG0138	bifunctional purine biosynthesis protein purh
HGJ18_RS06310	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HGJ18_RS06315	COG0653	protein targeting
HGJ18_RS06320	COG1725	Transcriptional regulator
HGJ18_RS06335	COG0736	holo-[acyl-carrier-protein] synthase activity
HGJ18_RS06350	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HGJ18_RS06355	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HGJ18_RS06365	COG2255	four-way junction helicase activity
HGJ18_RS06370	COG1979	alcohol dehydrogenase
HGJ18_RS06375	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HGJ18_RS06380	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HGJ18_RS06390	COG0731	radical SAM domain protein
HGJ18_RS06410	COG1047	Peptidyl-prolyl cis-trans
HGJ18_RS06445	COG0295	cytidine deaminase activity
HGJ18_RS06490	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HGJ18_RS06520	COG1079	Belongs to the binding-protein-dependent transport system permease family
HGJ18_RS06525	COG4603	Belongs to the binding-protein-dependent transport system permease family
HGJ18_RS06530	COG3845	ABC transporter
HGJ18_RS06535	COG1744	ABC transporter substrate-binding protein PnrA-like
HGJ18_RS06540	COG1234	tRNA 3'-trailer cleavage
HGJ18_RS06585	COG1283	sodium-dependent phosphate transmembrane transporter activity
HGJ18_RS06590	COG0475	glutathione-regulated potassium exporter activity
HGJ18_RS06605	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HGJ18_RS06610	COG2204	response regulator
HGJ18_RS06615	COG3852	Histidine kinase
HGJ18_RS06620	COG0470	DNA polymerase III
HGJ18_RS06625	COG1286	toxin biosynthetic process
HGJ18_RS06630	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HGJ18_RS06665	COG4254	PFAM FecR protein
HGJ18_RS06680	COG0823	Involved in the tonB-independent uptake of proteins
HGJ18_RS06690	COG1199	ATP-dependent helicase activity
HGJ18_RS06700	COG2885	chlorophyll binding
HGJ18_RS06710	COG0606	chelatase, subunit chli
HGJ18_RS06725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HGJ18_RS06730	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HGJ18_RS06745	COG0170	dolichyl monophosphate biosynthetic process
HGJ18_RS06755	COG1233	COG1233 Phytoene dehydrogenase and related
HGJ18_RS06765	COG1132	(ABC) transporter
HGJ18_RS06765	COG2375	cellular response to nickel ion
HGJ18_RS06775	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HGJ18_RS06800	COG2885	chlorophyll binding
HGJ18_RS06805	COG0084	hydrolase, TatD family'
HGJ18_RS06815	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HGJ18_RS06825	COG0438	transferase activity, transferring glycosyl groups
HGJ18_RS06830	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HGJ18_RS06840	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HGJ18_RS06845	COG3880	PFAM UvrB UvrC protein
HGJ18_RS06855	COG1136	(ABC) transporter
HGJ18_RS06860	COG4591	ABC-type transport system involved in lipoprotein release permease component
HGJ18_RS06870	COG0552	protein localization to endoplasmic reticulum
HGJ18_RS06900	COG4166	transmembrane transport
HGJ18_RS06920	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HGJ18_RS06965	COG1918	ferrous iron import across plasma membrane
HGJ18_RS06965	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HGJ18_RS06970	COG1918	ferrous iron import across plasma membrane
HGJ18_RS06990	COG1722	exodeoxyribonuclease VII activity
HGJ18_RS06995	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HGJ18_RS07000	COG0251	oxidation-reduction process
HGJ18_RS07025	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HGJ18_RS07030	COG5001	Diguanylate cyclase
HGJ18_RS07050	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HGJ18_RS07055	COG2204	response regulator
HGJ18_RS07060	COG0539	negative regulation of cytoplasmic translation
HGJ18_RS07075	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HGJ18_RS07080	COG0528	UMP kinase activity
HGJ18_RS07085	COG0484	heat shock protein binding
HGJ18_RS07090	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HGJ18_RS07095	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HGJ18_RS07100	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HGJ18_RS07105	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HGJ18_RS07125	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HGJ18_RS07130	COG3876	Protein conserved in bacteria
HGJ18_RS07145	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HGJ18_RS07155	COG0513	Belongs to the DEAD box helicase family
HGJ18_RS07160	COG0284	orotidine-5'-phosphate decarboxylase activity
HGJ18_RS07180	COG1131	(ABC) transporter
HGJ18_RS07205	COG1126	abc transporter atp-binding protein
HGJ18_RS07215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HGJ18_RS07240	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HGJ18_RS07280	COG1122	ATPase activity
HGJ18_RS07315	COG1770	oligopeptidase
HGJ18_RS07320	COG4953	penicillin-binding protein 1C
HGJ18_RS07325	COG3681	Belongs to the UPF0597 family
HGJ18_RS07350	COG0741	lytic transglycosylase activity
HGJ18_RS07350	COG1388	LysM domain
HGJ18_RS07360	COG1671	Belongs to the UPF0178 family
HGJ18_RS07365	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HGJ18_RS07375	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HGJ18_RS07380	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HGJ18_RS07395	COG1129	ABC transporter
HGJ18_RS07405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HGJ18_RS07410	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HGJ18_RS07410	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HGJ18_RS07415	COG2738	Putative neutral zinc metallopeptidase
HGJ18_RS07430	COG2226	methyltransferase
HGJ18_RS07450	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HGJ18_RS07470	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HGJ18_RS07475	COG0671	phosphoesterase, PA-phosphatase related
HGJ18_RS07500	COG1022	Amp-dependent synthetase and ligase
HGJ18_RS07505	COG1475	DNA binding
HGJ18_RS07515	COG0739	heme binding
HGJ18_RS07520	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HGJ18_RS07520	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HGJ18_RS07530	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HGJ18_RS07540	COG0156	8-amino-7-oxononanoate synthase activity
HGJ18_RS07550	COG1013	pyruvate-flavodoxin oxidoreductase activity
HGJ18_RS07550	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HGJ18_RS07550	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HGJ18_RS07550	COG0674	pyruvate-flavodoxin oxidoreductase activity
HGJ18_RS07555	COG0626	cystathionine gamma-synthase activity
HGJ18_RS07565	COG1757	Na H antiporter
HGJ18_RS07570	COG2056	Na+-H+ antiporter family
HGJ18_RS07590	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HGJ18_RS07610	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HGJ18_RS07630	COG2226	methyltransferase
HGJ18_RS07635	COG4211	Belongs to the binding-protein-dependent transport system permease family
HGJ18_RS07640	COG1129	ABC transporter
HGJ18_RS07645	COG1879	ABC-type sugar transport system periplasmic component
HGJ18_RS07660	COG0442	prolyl-tRNA aminoacylation
HGJ18_RS07680	COG0803	Belongs to the bacterial solute-binding protein 9 family
HGJ18_RS07690	COG2195	Cleaves the N-terminal amino acid of tripeptides
HGJ18_RS07695	COG1120	ATPase activity
HGJ18_RS07700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HGJ18_RS07715	COG4865	methylaspartate mutase activity
HGJ18_RS07735	COG3142	Participates in the control of copper homeostasis
HGJ18_RS07750	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HGJ18_RS07770	COG3657	addiction module killer protein
HGJ18_RS07790	COG0737	Belongs to the 5'-nucleotidase family
HGJ18_RS07795	COG0826	peptidase U32
HGJ18_RS07800	COG0657	acetylesterase activity
HGJ18_RS07805	COG1132	(ABC) transporter
HGJ18_RS07815	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HGJ18_RS07830	COG0101	tRNA pseudouridine synthase activity
HGJ18_RS07840	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HGJ18_RS07845	COG1639	'signal transduction protein
HGJ18_RS07860	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HGJ18_RS07865	COG0577	efflux transmembrane transporter activity
HGJ18_RS07865	COG1136	(ABC) transporter
HGJ18_RS07885	COG3956	TIGRFAM MazG family protein
HGJ18_RS07890	COG0545	Peptidyl-prolyl cis-trans isomerase
HGJ18_RS07895	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HGJ18_RS07900	COG1329	Transcriptional regulator
HGJ18_RS07905	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HGJ18_RS07905	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HGJ18_RS07910	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HGJ18_RS07925	COG0668	transmembrane transport
HGJ18_RS07940	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HGJ18_RS07945	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HGJ18_RS07950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HGJ18_RS07965	COG0792	nuclease activity
HGJ18_RS07980	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HGJ18_RS08000	COG3604	Transcriptional regulator
HGJ18_RS08010	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HGJ18_RS08025	COG1272	protein, Hemolysin III
HGJ18_RS08030	COG0739	heme binding
HGJ18_RS08030	COG0741	lytic transglycosylase activity
HGJ18_RS08030	COG1196	nuclear chromosome segregation
HGJ18_RS08055	COG0668	transmembrane transport
HGJ18_RS08060	COG2197	response regulator
HGJ18_RS08095	COG0542	response to heat
HGJ18_RS08100	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HGJ18_RS08105	COG2949	membrane
HGJ18_RS08110	COG0210	DNA helicase
HGJ18_RS08115	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HGJ18_RS08125	COG0495	leucyl-tRNA aminoacylation
HGJ18_RS08135	COG0750	zinc metalloprotease
HGJ18_RS08140	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HGJ18_RS08145	COG0575	Belongs to the CDS family
HGJ18_RS08150	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HGJ18_RS08155	COG0233	cytoplasmic translational termination
HGJ18_RS08160	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HGJ18_RS08165	COG0052	Belongs to the universal ribosomal protein uS2 family
HGJ18_RS08170	COG0424	maF-like protein
HGJ18_RS08175	COG1413	lyase activity
HGJ18_RS08200	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HGJ18_RS08205	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HGJ18_RS08215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HGJ18_RS08220	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HGJ18_RS08225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HGJ18_RS08240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HGJ18_RS08260	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HGJ18_RS08265	COG1131	(ABC) transporter
HGJ18_RS08280	COG4585	Histidine kinase
HGJ18_RS08290	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HGJ18_RS08300	COG1181	Belongs to the D-alanine--D-alanine ligase family
HGJ18_RS08315	COG0740	serine-type endopeptidase activity
HGJ18_RS08330	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HGJ18_RS08340	COG1847	R3H domain protein
HGJ18_RS08345	COG0706	membrane insertase activity
HGJ18_RS08350	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HGJ18_RS08360	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HGJ18_RS08370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HGJ18_RS08380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HGJ18_RS08410	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HGJ18_RS08425	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HGJ18_RS08430	COG0058	SHG alpha-glucan phosphorylase activity
HGJ18_RS08465	COG4608	Belongs to the ABC transporter superfamily
HGJ18_RS08475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGJ18_RS08480	COG0601	transmembrane transport
HGJ18_RS08485	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HGJ18_RS08490	COG0085	RNA polymerase activity
HGJ18_RS08495	COG0222	ribosome binding
HGJ18_RS08500	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HGJ18_RS08505	COG0081	regulation of translation
HGJ18_RS08510	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HGJ18_RS08515	COG0250	Participates in transcription elongation, termination and antitermination
HGJ18_RS08520	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HGJ18_RS08530	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HGJ18_RS08590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HGJ18_RS08595	COG1363	Peptidase, m42
HGJ18_RS08600	COG2274	protein secretion by the type I secretion system
HGJ18_RS08605	COG0281	malic enzyme
HGJ18_RS08620	COG3885	ferrous iron binding
HGJ18_RS08620	COG2078	PFAM AMMECR1 domain protein
HGJ18_RS08625	COG0666	response to abiotic stimulus
HGJ18_RS08630	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HGJ18_RS08635	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HGJ18_RS08655	COG0425	Belongs to the sulfur carrier protein TusA family
HGJ18_RS08670	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HGJ18_RS08680	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HGJ18_RS08690	COG0534	Mate efflux family protein
HGJ18_RS08695	COG0549	Belongs to the carbamate kinase family
HGJ18_RS08700	COG1921	L-seryl-tRNASec selenium transferase activity
HGJ18_RS08705	COG0322	excinuclease ABC activity
HGJ18_RS08715	COG0326	Molecular chaperone. Has ATPase activity
HGJ18_RS08750	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HGJ18_RS08755	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HGJ18_RS08760	COG1573	uracil-dna glycosylase
HGJ18_RS08805	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HGJ18_RS08830	COG1132	(ABC) transporter
HGJ18_RS08835	COG1132	(ABC) transporter
HGJ18_RS08840	COG1012	belongs to the aldehyde dehydrogenase family
HGJ18_RS08845	COG0357	Ribosomal RNA small subunit methyltransferase G
HGJ18_RS08855	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HGJ18_RS08865	COG1132	(ABC) transporter
HGJ18_RS08880	COG2604	Protein of unknown function DUF115
HGJ18_RS08895	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HGJ18_RS08930	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HGJ18_RS08980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HGJ18_RS09000	COG1132	(ABC) transporter
HGJ18_RS09005	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HGJ18_RS09010	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HGJ18_RS09030	COG1132	(ABC) transporter
HGJ18_RS09035	COG4988	ABC transporter
HGJ18_RS09045	COG1121	(ABC) transporter
HGJ18_RS09050	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HGJ18_RS09075	COG0301	tRNA thio-modification
HGJ18_RS09080	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HGJ18_RS09085	COG0328	RNA-DNA hybrid ribonuclease activity
HGJ18_RS09090	COG4443	Transcriptional Coactivator p15 (PC4)
HGJ18_RS09095	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HGJ18_RS09105	COG0166	Belongs to the GPI family
HGJ18_RS09110	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HGJ18_RS09120	COG0564	pseudouridine synthase activity
HGJ18_RS09135	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HGJ18_RS09140	COG3706	GGDEF domain
HGJ18_RS09165	COG3290	protein histidine kinase activity
HGJ18_RS09165	COG0840	transmembrane signaling receptor activity
HGJ18_RS09170	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HGJ18_RS09185	COG1362	aminopeptidase activity
HGJ18_RS09190	COG1054	Belongs to the UPF0176 family
HGJ18_RS09195	COG0724	RNA recognition motif
HGJ18_RS09220	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HGJ18_RS09230	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HGJ18_RS09240	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HGJ18_RS09250	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HGJ18_RS09260	COG3314	Sporulation integral membrane protein YlbJ
HGJ18_RS09265	COG0406	alpha-ribazole phosphatase activity
HGJ18_RS09270	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HGJ18_RS09285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HGJ18_RS09305	COG1477	protein flavinylation
HGJ18_RS09310	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HGJ18_RS09315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HGJ18_RS09330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HGJ18_RS09345	COG1132	(ABC) transporter
HGJ18_RS09350	COG1132	(ABC) transporter
HGJ18_RS09350	COG2375	cellular response to nickel ion
HGJ18_RS09380	COG3177	Filamentation induced by cAMP protein fic
HGJ18_RS09395	COG0446	pyridine nucleotide-disulphide oxidoreductase
HGJ18_RS09405	COG0517	IMP dehydrogenase activity
HGJ18_RS09405	COG4175	Glycine betaine
HGJ18_RS09415	COG2205	protein histidine kinase activity
HGJ18_RS09420	COG1136	(ABC) transporter
HGJ18_RS09430	COG0095	Lipoate-protein ligase
HGJ18_RS09435	COG1132	(ABC) transporter
HGJ18_RS09460	COG1131	(ABC) transporter
HGJ18_RS09485	COG1797	cobyrinic acid a,c-diamide synthase activity
HGJ18_RS09490	COG0784	Response regulator, receiver
HGJ18_RS09490	COG3437	response regulator, receiver
HGJ18_RS09510	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HGJ18_RS09515	COG0516	GMP reductase activity
HGJ18_RS09525	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HGJ18_RS09530	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HGJ18_RS09535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HGJ18_RS09565	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HGJ18_RS09600	COG1191	sigma factor activity
HGJ18_RS09615	COG1419	protein localization to endoplasmic reticulum
HGJ18_RS09620	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HGJ18_RS09630	COG0504	CTP synthase activity
HGJ18_RS09645	COG1747	RNA polymerase binding
HGJ18_RS09645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HGJ18_RS09655	COG0674	pyruvate-flavodoxin oxidoreductase activity
HGJ18_RS09655	COG1013	pyruvate-flavodoxin oxidoreductase activity
HGJ18_RS09655	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HGJ18_RS09655	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HGJ18_RS09660	COG2885	chlorophyll binding
HGJ18_RS09695	COG2378	regulation of single-species biofilm formation
HGJ18_RS09710	COG1136	(ABC) transporter
HGJ18_RS09715	COG5002	protein histidine kinase activity
HGJ18_RS09725	COG1473	amidohydrolase
HGJ18_RS09740	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HGJ18_RS09760	COG2201	protein-glutamate methylesterase activity
HGJ18_RS09780	COG1137	ATPase activity
HGJ18_RS09785	COG0193	aminoacyl-tRNA hydrolase activity
HGJ18_RS09795	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HGJ18_RS09805	COG0601	transmembrane transport
HGJ18_RS09810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGJ18_RS09815	COG0444	Belongs to the ABC transporter superfamily
HGJ18_RS09820	COG4608	Belongs to the ABC transporter superfamily
HGJ18_RS09825	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HGJ18_RS09850	COG0484	heat shock protein binding
HGJ18_RS09855	COG0443	Heat shock 70 kDa protein
HGJ18_RS09860	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HGJ18_RS09885	COG1120	ATPase activity
HGJ18_RS09910	COG0534	Mate efflux family protein
HGJ18_RS09920	COG0840	transmembrane signaling receptor activity
HGJ18_RS09955	COG1192	Involved in chromosome partitioning
HGJ18_RS09960	COG1475	DNA binding
HGJ18_RS09980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HGJ18_RS09985	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HGJ18_RS10000	COG1028	Short-chain dehydrogenase reductase Sdr
HGJ18_RS10015	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HGJ18_RS10040	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HGJ18_RS10045	COG0825	malonyl-CoA metabolic process
HGJ18_RS10050	COG2986	histidine ammonia-lyase
HGJ18_RS10065	COG0701	Predicted permease
HGJ18_RS10070	COG3689	TIGRFAM TIGR03943 family protein
HGJ18_RS10075	COG0714	Associated with various cellular activities
HGJ18_RS10110	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HGJ18_RS10115	COG0154	amidase activity
HGJ18_RS10120	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HGJ18_RS10195	COG1136	(ABC) transporter
HGJ18_RS10250	COG1028	Short-chain dehydrogenase reductase Sdr
HGJ18_RS10305	COG3041	Addiction module toxin RelE StbE family
HGJ18_RS10340	COG3850	Histidine kinase
HGJ18_RS10340	COG5002	protein histidine kinase activity
HGJ18_RS10345	COG0745	RESPONSE REGULATOR receiver
HGJ18_RS10370	COG4555	ABC transporter
HGJ18_RS10405	COG1151	hydroxylamine reductase activity
HGJ18_RS10420	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HGJ18_RS10425	COG1136	(ABC) transporter
HGJ18_RS10425	COG0577	efflux transmembrane transporter activity
HGJ18_RS10445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HGJ18_RS10485	COG0813	purine-nucleoside phosphorylase activity
HGJ18_RS10505	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HGJ18_RS10510	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HGJ18_RS10530	COG2235	arginine
HGJ18_RS10535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HGJ18_RS10540	COG1528	Iron-storage protein
HGJ18_RS10545	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HGJ18_RS10565	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HGJ18_RS10585	COG0515	serine threonine protein kinase
HGJ18_RS10605	COG0343	queuine tRNA-ribosyltransferase activity
HGJ18_RS10615	COG1381	Involved in DNA repair and RecF pathway recombination
HGJ18_RS10620	COG0514	ATP-dependent DNA helicase (RecQ)
HGJ18_RS10625	COG1592	Rubrerythrin
HGJ18_RS10635	COG1652	LysM domain
HGJ18_RS10635	COG2823	Periplasmic or secreted lipoprotein
HGJ18_RS10675	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HGJ18_RS10680	COG0501	Belongs to the peptidase M48B family
HGJ18_RS10690	COG0543	2 iron, 2 sulfur cluster binding
HGJ18_RS10720	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HGJ18_RS10735	COG1136	(ABC) transporter
HGJ18_RS10750	COG1116	anion transmembrane transporter activity
HGJ18_RS10755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HGJ18_RS10760	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HGJ18_RS10780	COG1653	transport
HGJ18_RS10785	COG0395	ABC-type sugar transport system, permease component
HGJ18_RS10790	COG1175	transmembrane transport
HGJ18_RS10795	COG3842	ATPase activity
HGJ18_RS10800	COG1840	ABC-type Fe3 transport system, periplasmic component
HGJ18_RS10805	COG4133	protoheme IX ABC transporter activity
HGJ18_RS10845	COG3842	ATPase activity
HGJ18_RS10850	COG0438	transferase activity, transferring glycosyl groups
HGJ18_RS10860	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HGJ18_RS10880	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HGJ18_RS10890	COG1132	(ABC) transporter
HGJ18_RS10905	COG0786	glutamate:sodium symporter activity
HGJ18_RS10910	COG1132	(ABC) transporter
HGJ18_RS10915	COG1132	(ABC) transporter
HGJ18_RS10940	COG2249	NAD(P)H dehydrogenase (quinone) activity
HGJ18_RS10950	COG2249	NAD(P)H dehydrogenase (quinone) activity
HGJ18_RS10965	COG0698	ribose 5-phosphate isomerase
HGJ18_RS10970	COG0039	L-malate dehydrogenase activity
HGJ18_RS10975	COG0534	Mate efflux family protein
HGJ18_RS10980	COG0574	Belongs to the PEP-utilizing enzyme family
HGJ18_RS10980	COG3848	Pyruvate phosphate dikinase
HGJ18_RS10985	COG1309	transcriptional regulator
HGJ18_RS10990	COG0840	transmembrane signaling receptor activity
HGJ18_RS11000	COG0728	peptidoglycan biosynthetic process
HGJ18_RS11035	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HGJ18_RS11040	COG3588	fructose-bisphosphate aldolase
HGJ18_RS11045	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HGJ18_RS11050	COG1132	(ABC) transporter
HGJ18_RS11055	COG1132	(ABC) transporter
HGJ18_RS11065	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HGJ18_RS11075	COG0569	domain protein
HGJ18_RS11080	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HGJ18_RS11100	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HGJ18_RS11110	COG3177	Filamentation induced by cAMP protein fic
HGJ18_RS11120	COG0012	GTP binding
HGJ18_RS11125	COG0616	signal peptide processing
HGJ18_RS11140	COG1136	(ABC) transporter
HGJ18_RS11155	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HGJ18_RS11160	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HGJ18_RS11165	COG0569	domain protein
HGJ18_RS11190	COG0714	Associated with various cellular activities
HGJ18_RS11195	COG4536	flavin adenine dinucleotide binding
HGJ18_RS11200	COG4536	flavin adenine dinucleotide binding
HGJ18_RS11215	COG0514	ATP-dependent DNA helicase (RecQ)
HGJ18_RS11225	COG1518	maintenance of DNA repeat elements
HGJ18_RS11230	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HGJ18_RS11240	COG1309	transcriptional regulator
HGJ18_RS11245	COG0534	Mate efflux family protein
HGJ18_RS11255	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HGJ18_RS11260	COG0628	permease
HGJ18_RS11265	COG0363	glucosamine-6-phosphate deaminase activity
HGJ18_RS11275	COG1309	transcriptional regulator
HGJ18_RS11290	COG1129	ABC transporter
HGJ18_RS11320	COG1132	(ABC) transporter
HGJ18_RS11320	COG2375	cellular response to nickel ion
HGJ18_RS11325	COG1132	(ABC) transporter
HGJ18_RS11365	COG2226	methyltransferase
HGJ18_RS11380	COG1129	ABC transporter
HGJ18_RS11410	COG3189	MarR family transcriptional regulator
HGJ18_RS11415	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HGJ18_RS11420	COG1309	transcriptional regulator
HGJ18_RS11425	COG1132	(ABC) transporter
HGJ18_RS11430	COG1132	(ABC) transporter
HGJ18_RS11435	COG1129	ABC transporter
HGJ18_RS11460	COG3118	belongs to the thioredoxin family
HGJ18_RS11465	COG1418	mRNA catabolic process
HGJ18_RS11530	COG0592	DNA-directed DNA polymerase activity
HGJ18_RS11535	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HGJ18_RS11690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HGJ18_RS11705	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HGJ18_RS11725	COG1929	Belongs to the glycerate kinase type-1 family
HGJ18_RS11730	COG2610	gluconate transmembrane transporter activity
HGJ18_RS11745	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HGJ18_RS11760	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HGJ18_RS11780	COG2337	Toxic component of a toxin-antitoxin (TA) module
HGJ18_RS11810	COG2184	nucleotidyltransferase activity
HGJ18_RS11820	COG0730	response to heat
HGJ18_RS11840	COG4208	sulfate ABC transporter
HGJ18_RS11855	COG0840	transmembrane signaling receptor activity
HGJ18_RS11870	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HGJ18_RS11875	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HGJ18_RS11880	COG1674	ftsk spoiiie
HGJ18_RS11885	COG1968	undecaprenyl-diphosphatase activity
HGJ18_RS11890	COG0419	ATPase involved in DNA repair
HGJ18_RS11895	COG0420	3'-5' exonuclease activity
HGJ18_RS11900	COG0840	transmembrane signaling receptor activity
HGJ18_RS11900	COG3290	protein histidine kinase activity
HGJ18_RS11910	COG1131	(ABC) transporter
HGJ18_RS11930	COG0716	FMN binding
HGJ18_RS11970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HGJ18_RS12000	COG0446	pyridine nucleotide-disulphide oxidoreductase
HGJ18_RS12025	COG4585	Histidine kinase
HGJ18_RS12030	COG1473	amidohydrolase
HGJ18_RS12050	COG1373	ATPase (AAA superfamily
HGJ18_RS12065	COG4143	(ABC) transporter
HGJ18_RS12075	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HGJ18_RS12090	COG1070	Carbohydrate kinase
HGJ18_RS12100	COG0446	pyridine nucleotide-disulphide oxidoreductase
HGJ18_RS12110	COG2186	Transcriptional regulator
HGJ18_RS12120	COG1823	symporter activity
HGJ18_RS12125	COG0540	Belongs to the ATCase OTCase family
HGJ18_RS12125	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HGJ18_RS12130	COG5002	protein histidine kinase activity
HGJ18_RS12130	COG5001	Diguanylate cyclase
HGJ18_RS12180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HGJ18_RS12200	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HGJ18_RS12215	COG1774	PSP1 C-terminal conserved region
HGJ18_RS12220	COG1728	Protein conserved in bacteria
HGJ18_RS12230	COG0739	heme binding
HGJ18_RS12250	COG0366	Alpha amylase catalytic
HGJ18_RS12260	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HGJ18_RS12265	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HGJ18_RS12270	COG1104	cysteine desulfurase activity
HGJ18_RS12285	COG4946	Tricorn protease homolog
HGJ18_RS12285	COG0823	Involved in the tonB-independent uptake of proteins
HGJ18_RS12285	COG1506	peptidase
HGJ18_RS12315	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HGJ18_RS12320	COG0215	cysteine-tRNA ligase activity
HGJ18_RS12335	COG1305	Transglutaminase-like
HGJ18_RS12340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HGJ18_RS12345	COG0569	domain protein
HGJ18_RS12350	COG2887	Belongs to the helicase family. UvrD subfamily
HGJ18_RS12355	COG1074	ATP-dependent DNA helicase activity
HGJ18_RS12375	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HGJ18_RS12395	COG0840	transmembrane signaling receptor activity
HGJ18_RS12400	COG0826	peptidase U32
HGJ18_RS12405	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HGJ18_RS12410	COG1509	lysine 2,3-aminomutase activity
HGJ18_RS12415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HGJ18_RS12420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HGJ18_RS12435	COG0205	6-phosphofructokinase activity
HGJ18_RS12475	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HGJ18_RS12485	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HGJ18_RS12490	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HGJ18_RS12495	COG1684	flagellar biosynthetic protein fliR
HGJ18_RS12500	COG1987	bacterial-type flagellum assembly
HGJ18_RS12525	COG1228	amidohydrolase
HGJ18_RS12540	COG0457	Tetratricopeptide repeat
HGJ18_RS12545	COG0280	phosphate acetyltransferase
HGJ18_RS12555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HGJ18_RS12560	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HGJ18_RS12580	COG1401	restriction endodeoxyribonuclease activity
HGJ18_RS12625	COG1132	(ABC) transporter
HGJ18_RS12655	COG1472	Belongs to the glycosyl hydrolase 3 family
HGJ18_RS12675	COG0423	glycine-tRNA ligase activity
HGJ18_RS12680	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HGJ18_RS12690	COG1363	Peptidase, m42
HGJ18_RS12710	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HGJ18_RS12715	COG1966	Carbon starvation protein
HGJ18_RS12720	COG0450	alkyl hydroperoxide reductase
HGJ18_RS12725	COG0494	nUDIX hydrolase
HGJ18_RS12735	COG2217	Heavy metal translocating P-type atpase
HGJ18_RS12745	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HGJ18_RS12765	COG0187	DNA topoisomerase II activity