locus-tag	class	description
E4N85_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4N85_RS00015	COG0587	DNA-directed DNA polymerase activity
E4N85_RS00040	COG0840	transmembrane signaling receptor activity
E4N85_RS00045	COG1132	(ABC) transporter
E4N85_RS00050	COG1132	(ABC) transporter
E4N85_RS00090	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E4N85_RS00105	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4N85_RS00110	COG1360	Flagellar Motor Protein
E4N85_RS00115	COG1580	Controls the rotational direction of flagella during chemotaxis
E4N85_RS00120	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N85_RS00125	COG1776	CheC inhibitor of MCP methylation
E4N85_RS00125	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N85_RS00135	COG1338	Plays a role in the flagellum-specific transport system
E4N85_RS00200	COG4166	transmembrane transport
E4N85_RS00205	COG2423	ornithine cyclodeaminase activity
E4N85_RS00210	COG0739	heme binding
E4N85_RS00215	COG4545	Glutaredoxin-related protein
E4N85_RS00230	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4N85_RS00255	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4N85_RS00265	COG0732	type I restriction modification DNA specificity domain
E4N85_RS00270	COG0732	type I restriction modification DNA specificity domain
E4N85_RS00275	COG4974	Belongs to the 'phage' integrase family
E4N85_RS00300	COG3116	cell division
E4N85_RS00300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4N85_RS00305	COG0084	hydrolase, TatD family'
E4N85_RS00320	COG2199	diguanylate cyclase activity
E4N85_RS00320	COG2203	Gaf domain
E4N85_RS00330	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4N85_RS00360	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4N85_RS00370	COG2239	Acts as a magnesium transporter
E4N85_RS00380	COG0546	phosphoglycolate phosphatase activity
E4N85_RS00385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4N85_RS00420	COG2211	Major facilitator Superfamily
E4N85_RS00450	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4N85_RS00450	COG1747	RNA polymerase binding
E4N85_RS00465	COG0504	CTP synthase activity
E4N85_RS00475	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4N85_RS00480	COG1419	protein localization to endoplasmic reticulum
E4N85_RS00495	COG1191	sigma factor activity
E4N85_RS00525	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4N85_RS00555	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4N85_RS00560	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4N85_RS00565	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E4N85_RS00575	COG0516	GMP reductase activity
E4N85_RS00580	COG2801	Transposase and inactivated derivatives
E4N85_RS00585	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4N85_RS00605	COG3437	response regulator, receiver
E4N85_RS00605	COG0784	Response regulator, receiver
E4N85_RS00610	COG1797	cobyrinic acid a,c-diamide synthase activity
E4N85_RS00640	COG1122	ATPase activity
E4N85_RS00645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4N85_RS00650	COG1131	(ABC) transporter
E4N85_RS00660	COG0095	Lipoate-protein ligase
E4N85_RS00670	COG1136	(ABC) transporter
E4N85_RS00685	COG4175	Glycine betaine
E4N85_RS00685	COG3448	diguanylate cyclase activity
E4N85_RS00695	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4N85_RS00710	COG3177	Filamentation induced by cAMP protein fic
E4N85_RS00760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N85_RS00770	COG0747	negative chemotaxis
E4N85_RS00780	COG2375	cellular response to nickel ion
E4N85_RS00780	COG1132	(ABC) transporter
E4N85_RS00785	COG1132	(ABC) transporter
E4N85_RS00800	COG1129	ABC transporter
E4N85_RS00830	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4N85_RS00845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4N85_RS00850	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4N85_RS00855	COG1477	protein flavinylation
E4N85_RS00875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N85_RS00890	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E4N85_RS00895	COG0406	alpha-ribazole phosphatase activity
E4N85_RS00905	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4N85_RS00915	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4N85_RS00925	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4N85_RS00935	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4N85_RS00960	COG0724	RNA recognition motif
E4N85_RS00965	COG1054	Belongs to the UPF0176 family
E4N85_RS00970	COG1362	aminopeptidase activity
E4N85_RS00985	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4N85_RS00990	COG3290	protein histidine kinase activity
E4N85_RS00990	COG0840	transmembrane signaling receptor activity
E4N85_RS01015	COG3706	GGDEF domain
E4N85_RS01020	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4N85_RS01045	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4N85_RS01050	COG0166	Belongs to the GPI family
E4N85_RS01055	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4N85_RS01060	COG4443	Transcriptional Coactivator p15 (PC4)
E4N85_RS01065	COG0328	RNA-DNA hybrid ribonuclease activity
E4N85_RS01070	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4N85_RS01075	COG0301	tRNA thio-modification
E4N85_RS01095	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N85_RS01100	COG1121	(ABC) transporter
E4N85_RS01110	COG4988	ABC transporter
E4N85_RS01115	COG1132	(ABC) transporter
E4N85_RS01125	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4N85_RS01130	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E4N85_RS01135	COG1132	(ABC) transporter
E4N85_RS01155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4N85_RS01200	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4N85_RS01225	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4N85_RS01240	COG2604	Protein of unknown function DUF115
E4N85_RS01275	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4N85_RS01290	COG0357	Ribosomal RNA small subunit methyltransferase G
E4N85_RS01295	COG1012	belongs to the aldehyde dehydrogenase family
E4N85_RS01305	COG1132	(ABC) transporter
E4N85_RS01310	COG1132	(ABC) transporter
E4N85_RS01335	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4N85_RS01370	COG0840	transmembrane signaling receptor activity
E4N85_RS01380	COG1573	uracil-dna glycosylase
E4N85_RS01385	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4N85_RS01420	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4N85_RS01460	COG0326	Molecular chaperone. Has ATPase activity
E4N85_RS01470	COG0322	excinuclease ABC activity
E4N85_RS01475	COG1921	L-seryl-tRNASec selenium transferase activity
E4N85_RS01485	COG0549	Belongs to the carbamate kinase family
E4N85_RS01500	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4N85_RS01510	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E4N85_RS01525	COG0425	Belongs to the sulfur carrier protein TusA family
E4N85_RS01545	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4N85_RS01585	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4N85_RS01590	COG0666	response to abiotic stimulus
E4N85_RS01595	COG2078	PFAM AMMECR1 domain protein
E4N85_RS01595	COG3885	ferrous iron binding
E4N85_RS01610	COG0281	malic enzyme
E4N85_RS01635	COG1363	Peptidase, m42
E4N85_RS01640	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4N85_RS01670	COG1652	LysM domain
E4N85_RS01700	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4N85_RS01710	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4N85_RS01715	COG0250	Participates in transcription elongation, termination and antitermination
E4N85_RS01720	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4N85_RS01725	COG0081	regulation of translation
E4N85_RS01730	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4N85_RS01735	COG0222	ribosome binding
E4N85_RS01740	COG0085	RNA polymerase activity
E4N85_RS01745	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E4N85_RS01790	COG0058	SHG alpha-glucan phosphorylase activity
E4N85_RS01795	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4N85_RS01810	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4N85_RS01830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N85_RS01840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4N85_RS01845	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E4N85_RS01855	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4N85_RS01860	COG0706	membrane insertase activity
E4N85_RS01865	COG1847	R3H domain protein
E4N85_RS01875	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4N85_RS01885	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
E4N85_RS01890	COG0740	serine-type endopeptidase activity
E4N85_RS01905	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4N85_RS01915	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E4N85_RS01920	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
E4N85_RS01925	COG4585	Histidine kinase
E4N85_RS01940	COG1131	(ABC) transporter
E4N85_RS01945	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4N85_RS01965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4N85_RS01980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4N85_RS01985	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4N85_RS01990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N85_RS02000	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E4N85_RS02005	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
E4N85_RS02030	COG1413	lyase activity
E4N85_RS02035	COG0424	maF-like protein
E4N85_RS02040	COG0052	Belongs to the universal ribosomal protein uS2 family
E4N85_RS02045	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E4N85_RS02050	COG0233	cytoplasmic translational termination
E4N85_RS02055	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4N85_RS02060	COG0575	Belongs to the CDS family
E4N85_RS02065	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4N85_RS02070	COG0750	zinc metalloprotease
E4N85_RS02080	COG0495	leucyl-tRNA aminoacylation
E4N85_RS02090	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4N85_RS02095	COG0210	DNA helicase
E4N85_RS02105	COG2949	membrane
E4N85_RS02125	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E4N85_RS02130	COG0542	response to heat
E4N85_RS02145	COG2197	response regulator
E4N85_RS02150	COG0668	transmembrane transport
E4N85_RS02175	COG0739	heme binding
E4N85_RS02175	COG0741	lytic transglycosylase activity
E4N85_RS02175	COG1196	nuclear chromosome segregation
E4N85_RS02180	COG1272	protein, Hemolysin III
E4N85_RS02195	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4N85_RS02225	COG3604	Transcriptional regulator
E4N85_RS02245	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4N85_RS02260	COG0792	nuclease activity
E4N85_RS02275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N85_RS02280	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4N85_RS02285	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4N85_RS02305	COG0668	transmembrane transport
E4N85_RS02320	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4N85_RS02325	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4N85_RS02325	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E4N85_RS02330	COG1329	Transcriptional regulator
E4N85_RS02335	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4N85_RS02345	COG0545	Peptidyl-prolyl cis-trans isomerase
E4N85_RS02350	COG3956	TIGRFAM MazG family protein
E4N85_RS02370	COG0577	efflux transmembrane transporter activity
E4N85_RS02370	COG1136	(ABC) transporter
E4N85_RS02375	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E4N85_RS02390	COG1639	'signal transduction protein
E4N85_RS02395	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4N85_RS02405	COG0101	tRNA pseudouridine synthase activity
E4N85_RS02420	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4N85_RS02430	COG1132	(ABC) transporter
E4N85_RS02440	COG0826	peptidase U32
E4N85_RS02460	COG0737	Belongs to the 5'-nucleotidase family
E4N85_RS02490	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4N85_RS02515	COG3142	Participates in the control of copper homeostasis
E4N85_RS02545	COG4865	methylaspartate mutase activity
E4N85_RS02560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N85_RS02565	COG1120	ATPase activity
E4N85_RS02580	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4N85_RS02590	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4N85_RS02610	COG0442	prolyl-tRNA aminoacylation
E4N85_RS02635	COG1879	ABC-type sugar transport system periplasmic component
E4N85_RS02640	COG1129	ABC transporter
E4N85_RS02645	COG4211	Belongs to the binding-protein-dependent transport system permease family
E4N85_RS02660	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4N85_RS02680	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4N85_RS02700	COG1757	Na H antiporter
E4N85_RS02710	COG0626	cystathionine gamma-synthase activity
E4N85_RS02715	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4N85_RS02720	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4N85_RS02720	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4N85_RS02720	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4N85_RS02720	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4N85_RS02735	COG0156	8-amino-7-oxononanoate synthase activity
E4N85_RS02745	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4N85_RS02760	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4N85_RS02760	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E4N85_RS02765	COG0739	heme binding
E4N85_RS02775	COG1475	DNA binding
E4N85_RS02780	COG1022	Amp-dependent synthetase and ligase
E4N85_RS02805	COG0671	phosphoesterase, PA-phosphatase related
E4N85_RS02810	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E4N85_RS02830	COG1028	Short-chain dehydrogenase reductase Sdr
E4N85_RS02880	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4N85_RS02890	COG2738	Putative neutral zinc metallopeptidase
E4N85_RS02895	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
E4N85_RS02895	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4N85_RS02900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4N85_RS02910	COG1129	ABC transporter
E4N85_RS02925	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4N85_RS02930	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E4N85_RS02940	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
E4N85_RS02945	COG1671	Belongs to the UPF0178 family
E4N85_RS02955	COG1388	LysM domain
E4N85_RS02955	COG0741	lytic transglycosylase activity
E4N85_RS02985	COG3681	Belongs to the UPF0597 family
E4N85_RS02990	COG4953	penicillin-binding protein 1C
E4N85_RS03025	COG1122	ATPase activity
E4N85_RS03065	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E4N85_RS03110	COG1131	(ABC) transporter
E4N85_RS03130	COG0284	orotidine-5'-phosphate decarboxylase activity
E4N85_RS03135	COG0513	Belongs to the DEAD box helicase family
E4N85_RS03145	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4N85_RS03185	COG3876	Protein conserved in bacteria
E4N85_RS03190	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4N85_RS03210	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4N85_RS03215	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4N85_RS03220	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4N85_RS03225	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E4N85_RS03230	COG0484	heat shock protein binding
E4N85_RS03235	COG0528	UMP kinase activity
E4N85_RS03240	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E4N85_RS03255	COG0539	negative regulation of cytoplasmic translation
E4N85_RS03260	COG2204	response regulator
E4N85_RS03265	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4N85_RS03285	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E4N85_RS03310	COG0251	oxidation-reduction process
E4N85_RS03320	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4N85_RS03325	COG1722	exodeoxyribonuclease VII activity
E4N85_RS03335	COG1918	ferrous iron import across plasma membrane
E4N85_RS03340	COG1918	ferrous iron import across plasma membrane
E4N85_RS03340	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E4N85_RS03385	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4N85_RS03405	COG4166	transmembrane transport
E4N85_RS03435	COG0552	protein localization to endoplasmic reticulum
E4N85_RS03445	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4N85_RS03450	COG1136	(ABC) transporter
E4N85_RS03460	COG3880	PFAM UvrB UvrC protein
E4N85_RS03465	COG3869	Catalyzes the specific phosphorylation of arginine residues in
E4N85_RS03475	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4N85_RS03480	COG0438	transferase activity, transferring glycosyl groups
E4N85_RS03490	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4N85_RS03500	COG0084	hydrolase, TatD family'
E4N85_RS03505	COG2885	chlorophyll binding
E4N85_RS03565	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4N85_RS03575	COG1132	(ABC) transporter
E4N85_RS03575	COG2375	cellular response to nickel ion
E4N85_RS03590	COG1309	transcriptional regulator
E4N85_RS03635	COG1164	Oligoendopeptidase f
E4N85_RS03645	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4N85_RS03650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4N85_RS03655	COG0606	chelatase, subunit chli
E4N85_RS03665	COG2885	chlorophyll binding
E4N85_RS03665	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E4N85_RS03675	COG1199	ATP-dependent helicase activity
E4N85_RS03685	COG0823	Involved in the tonB-independent uptake of proteins
E4N85_RS03700	COG4254	PFAM FecR protein
E4N85_RS03750	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4N85_RS03755	COG1286	toxin biosynthetic process
E4N85_RS03760	COG0470	DNA polymerase III
E4N85_RS03765	COG3852	Histidine kinase
E4N85_RS03770	COG2204	response regulator
E4N85_RS03775	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E4N85_RS03790	COG0475	glutathione-regulated potassium exporter activity
E4N85_RS03795	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4N85_RS03870	COG1234	tRNA 3'-trailer cleavage
E4N85_RS03875	COG1744	ABC transporter substrate-binding protein PnrA-like
E4N85_RS03880	COG3845	ABC transporter
E4N85_RS03885	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4N85_RS03890	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4N85_RS03920	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E4N85_RS03970	COG0295	cytidine deaminase activity
E4N85_RS04010	COG1047	Peptidyl-prolyl cis-trans
E4N85_RS04035	COG0731	radical SAM domain protein
E4N85_RS04050	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4N85_RS04055	COG1979	alcohol dehydrogenase
E4N85_RS04060	COG2255	four-way junction helicase activity
E4N85_RS04070	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E4N85_RS04075	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4N85_RS04090	COG0736	holo-[acyl-carrier-protein] synthase activity
E4N85_RS04105	COG0653	protein targeting
E4N85_RS04110	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4N85_RS04115	COG0138	bifunctional purine biosynthesis protein purh
E4N85_RS04120	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E4N85_RS04125	COG2878	Part of a membrane complex involved in electron transport
E4N85_RS04130	COG0481	GTPase activity
E4N85_RS04140	COG1114	Component of the transport system for branched-chain amino acids
E4N85_RS04155	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N85_RS04170	COG2723	6-phospho-beta-galactosidase activity
E4N85_RS04185	COG0488	(ABC) transporter
E4N85_RS04205	COG0793	Belongs to the peptidase S41A family
E4N85_RS04235	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4N85_RS04240	COG0632	four-way junction helicase activity
E4N85_RS04285	COG1136	(ABC) transporter
E4N85_RS04290	COG0577	efflux transmembrane transporter activity
E4N85_RS04290	COG1136	(ABC) transporter
E4N85_RS04495	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4N85_RS04510	COG1418	mRNA catabolic process
E4N85_RS04535	COG2033	superoxide reductase activity
E4N85_RS04540	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4N85_RS04545	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4N85_RS04555	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4N85_RS04560	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4N85_RS04575	COG0799	negative regulation of ribosome biogenesis
E4N85_RS04580	COG2059	Chromate
E4N85_RS04615	COG0739	heme binding
E4N85_RS04625	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4N85_RS04635	COG0708	Exodeoxyribonuclease III
E4N85_RS04640	COG0024	Methionine aminopeptidase
E4N85_RS04655	COG3250	beta-galactosidase activity
E4N85_RS04675	COG0617	tRNA 3'-terminal CCA addition
E4N85_RS04695	COG0519	Catalyzes the synthesis of GMP from XMP
E4N85_RS04710	COG0126	phosphoglycerate kinase activity
E4N85_RS04715	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4N85_RS04735	COG0268	Binds directly to 16S ribosomal RNA
E4N85_RS04740	COG0776	regulation of translation
E4N85_RS04745	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4N85_RS04755	COG1058	Belongs to the CinA family
E4N85_RS04755	COG1546	Belongs to the CinA family
E4N85_RS04800	COG0588	phosphoglycerate mutase activity
E4N85_RS04830	COG1131	(ABC) transporter
E4N85_RS04840	COG0457	Tetratricopeptide repeat
E4N85_RS04845	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4N85_RS04850	COG2203	Gaf domain
E4N85_RS04850	COG3706	GGDEF domain
E4N85_RS04850	COG4251	negative regulation of phosphorylation
E4N85_RS04850	COG5001	Diguanylate cyclase
E4N85_RS04855	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4N85_RS04860	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
E4N85_RS04865	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
E4N85_RS04870	COG1394	ATPase activity, coupled to movement of substances
E4N85_RS04875	COG1269	ATP hydrolysis coupled proton transport
E4N85_RS04885	COG0360	Binds together with S18 to 16S ribosomal RNA
E4N85_RS04890	COG0629	single-stranded DNA binding
E4N85_RS04895	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4N85_RS04900	COG0359	binds to the 23S rRNA
E4N85_RS04905	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4N85_RS04910	COG0740	serine-type endopeptidase activity
E4N85_RS04915	COG0544	peptidyl-prolyl cis-trans isomerase activity
E4N85_RS04935	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4N85_RS04940	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E4N85_RS04960	COG0305	Participates in initiation and elongation during chromosome replication
E4N85_RS04970	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4N85_RS04975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4N85_RS04980	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4N85_RS05005	COG1132	(ABC) transporter
E4N85_RS05010	COG1132	(ABC) transporter
E4N85_RS05015	COG1268	BioY protein
E4N85_RS05020	COG1122	ATPase activity
E4N85_RS05040	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4N85_RS05055	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4N85_RS05060	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4N85_RS05070	COG0237	dephospho-CoA kinase activity
E4N85_RS05075	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4N85_RS05075	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4N85_RS05075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4N85_RS05095	COG3052	prosthetic group binding
E4N85_RS05115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4N85_RS05125	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4N85_RS05130	COG0509	glycine decarboxylation via glycine cleavage system
E4N85_RS05135	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4N85_RS05140	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4N85_RS05145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4N85_RS05165	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E4N85_RS05215	COG1129	ABC transporter
E4N85_RS05220	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
E4N85_RS05225	COG0493	'glutamate synthase
E4N85_RS05225	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4N85_RS05235	COG0488	(ABC) transporter
E4N85_RS05240	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4N85_RS05250	COG0835	chemotaxis
E4N85_RS05265	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4N85_RS05270	COG0531	amino acid
E4N85_RS05280	COG0297	glycogen (starch) synthase activity
E4N85_RS05285	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
E4N85_RS05290	COG2982	Protein involved in outer membrane biogenesis
E4N85_RS05315	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N85_RS05320	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E4N85_RS05515	COG0095	Lipoate-protein ligase
E4N85_RS05520	COG0205	6-phosphofructokinase activity
E4N85_RS05525	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4N85_RS05530	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E4N85_RS05535	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4N85_RS05555	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4N85_RS05570	COG0727	PFAM Uncharacterised protein family (UPF0153)
E4N85_RS05590	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4N85_RS05595	COG0142	geranyltranstransferase activity
E4N85_RS05605	COG1692	metallophosphoesterase
E4N85_RS05625	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
E4N85_RS05655	COG1136	(ABC) transporter
E4N85_RS05660	COG0577	efflux transmembrane transporter activity
E4N85_RS05660	COG1136	(ABC) transporter
E4N85_RS05675	COG3470	protein probably involved in high-affinity Fe2 transport
E4N85_RS05680	COG0672	)-iron permease
E4N85_RS05685	COG1136	(ABC) transporter
E4N85_RS05695	COG1760	l-serine dehydratase
E4N85_RS05700	COG1760	l-serine dehydratase
E4N85_RS05710	COG0254	rRNA binding
E4N85_RS05715	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4N85_RS05730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N85_RS05730	COG0574	Belongs to the PEP-utilizing enzyme family
E4N85_RS05740	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4N85_RS05745	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4N85_RS05755	COG1196	nuclear chromosome segregation
E4N85_RS05765	COG2201	protein-glutamate methylesterase activity
E4N85_RS05775	COG0835	chemotaxis
E4N85_RS05780	COG0643	Histidine kinase
E4N85_RS05780	COG2198	Histidine kinase
E4N85_RS05795	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4N85_RS05800	COG0217	transcriptional regulatory protein
E4N85_RS05805	COG2801	Transposase and inactivated derivatives
E4N85_RS05855	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N85_RS05860	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N85_RS05870	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4N85_RS05870	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E4N85_RS05885	COG0802	atpase or kinase
E4N85_RS05895	COG3437	response regulator, receiver
E4N85_RS05895	COG2770	Histidine kinase
E4N85_RS05900	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4N85_RS05910	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E4N85_RS05920	COG0009	L-threonylcarbamoyladenylate synthase
E4N85_RS05960	COG2190	(PTS) system
E4N85_RS05960	COG2211	Major facilitator Superfamily
E4N85_RS05970	COG2801	Transposase and inactivated derivatives
E4N85_RS05980	COG1193	negative regulation of DNA recombination
E4N85_RS05985	COG1162	GTPase activity
E4N85_RS05995	COG1132	(ABC) transporter
E4N85_RS06000	COG1132	(ABC) transporter
E4N85_RS06005	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4N85_RS06020	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E4N85_RS06030	COG0124	histidyl-tRNA synthetase
E4N85_RS06045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4N85_RS06050	COG0297	glycogen (starch) synthase activity
E4N85_RS06060	COG0706	membrane insertase activity
E4N85_RS06065	COG0706	membrane insertase activity
E4N85_RS06075	COG0706	membrane insertase activity
E4N85_RS06085	COG0706	membrane insertase activity
E4N85_RS06090	COG0706	membrane insertase activity
E4N85_RS06100	COG0463	Glycosyl transferase, family 2
E4N85_RS06110	COG3306	glycosyltransferase involved in LPS biosynthesis
E4N85_RS06135	COG0463	Glycosyl transferase, family 2
E4N85_RS06135	COG1216	Glycosyl transferase, family 2
E4N85_RS06150	COG1215	transferase activity, transferring glycosyl groups
E4N85_RS06155	COG1215	transferase activity, transferring glycosyl groups
E4N85_RS06165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4N85_RS06205	COG0463	Glycosyl transferase, family 2
E4N85_RS06210	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E4N85_RS06230	COG2813	Specifically methylates the guanine in position
E4N85_RS06255	COG0028	Belongs to the TPP enzyme family
E4N85_RS06255	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
E4N85_RS06265	COG0475	glutathione-regulated potassium exporter activity
E4N85_RS06290	COG1078	dGTPase activity
E4N85_RS06300	COG0047	phosphoribosylformylglycinamidine synthase activity
E4N85_RS06310	COG0488	(ABC) transporter
E4N85_RS06320	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4N85_RS06320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4N85_RS06325	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E4N85_RS06365	COG4658	electron transport chain
E4N85_RS06370	COG4656	Part of a membrane complex involved in electron transport
E4N85_RS06385	COG0564	pseudouridine synthase activity
E4N85_RS06395	COG2217	Heavy metal translocating P-type atpase
E4N85_RS06400	COG0640	Transcriptional regulator
E4N85_RS06405	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
E4N85_RS06440	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4N85_RS06455	COG0557	exoribonuclease II activity
E4N85_RS06460	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4N85_RS06460	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4N85_RS06465	COG0556	nucleotide-excision repair
E4N85_RS06475	COG0346	lactoylglutathione lyase activity
E4N85_RS06480	COG0525	valine-tRNA ligase activity
E4N85_RS06495	COG2252	PERMEase
E4N85_RS06530	COG0772	Belongs to the SEDS family
E4N85_RS06535	COG0768	penicillin binding
E4N85_RS06550	COG1077	Cell shape determining protein MreB Mrl
E4N85_RS06570	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4N85_RS06575	COG0358	DNA primase activity
E4N85_RS06585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N85_RS06590	COG0457	Tetratricopeptide repeat
E4N85_RS06595	COG0037	tRNA processing
E4N85_RS06600	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4N85_RS06610	COG2088	sporulation resulting in formation of a cellular spore
E4N85_RS06615	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E4N85_RS06640	COG0330	HflC and HflK could
E4N85_RS06645	COG0330	HflC and HflK could
E4N85_RS06655	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4N85_RS06680	COG1739	Uncharacterized protein family UPF0029
E4N85_RS06705	COG2604	Protein of unknown function DUF115
E4N85_RS06710	COG0768	penicillin binding
E4N85_RS06720	COG0433	COG0433 Predicted ATPase
E4N85_RS06725	COG4988	ABC transporter
E4N85_RS06735	COG0312	modulator of DNA gyrase
E4N85_RS06740	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4N85_RS06770	COG0497	DNA recombination
E4N85_RS06790	COG0791	NLP P60 protein
E4N85_RS06790	COG1388	LysM domain
E4N85_RS06800	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E4N85_RS06805	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4N85_RS06810	COG0312	modulator of DNA gyrase
E4N85_RS06835	COG0535	radical SAM domain protein
E4N85_RS06880	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N85_RS06885	COG0840	transmembrane signaling receptor activity
E4N85_RS06910	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4N85_RS06915	COG4475	Protein of unknown function (DUF436)
E4N85_RS06920	COG3421	Type III restriction
E4N85_RS06925	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E4N85_RS06945	COG0601	transmembrane transport
E4N85_RS06950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N85_RS06960	COG0444	Belongs to the ABC transporter superfamily
E4N85_RS06965	COG4608	Belongs to the ABC transporter superfamily
E4N85_RS07000	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E4N85_RS07005	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E4N85_RS07010	COG3118	belongs to the thioredoxin family
E4N85_RS07025	COG4750	Nucleotidyl transferase
E4N85_RS07030	COG1115	amino acid carrier protein
E4N85_RS07055	COG1193	negative regulation of DNA recombination
E4N85_RS07105	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4N85_RS07110	COG1480	7TM receptor with intracellular HD hydrolase
E4N85_RS07115	COG1702	phosphate starvation-inducible protein PhoH
E4N85_RS07130	COG0149	triose-phosphate isomerase activity
E4N85_RS07140	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4N85_RS07160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N85_RS07175	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4N85_RS07180	COG1121	(ABC) transporter
E4N85_RS07185	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N85_RS07190	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N85_RS07215	COG1157	protein secretion by the type III secretion system
E4N85_RS07220	COG1317	bacterial-type flagellum organization
E4N85_RS07230	COG1766	The M ring may be actively involved in energy transduction
E4N85_RS07235	COG1677	Flagellar hook-basal body complex protein FliE
E4N85_RS07250	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E4N85_RS07255	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E4N85_RS07260	COG4974	Belongs to the 'phage' integrase family
E4N85_RS07265	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4N85_RS07265	COG0551	DNA topoisomerase type I activity
E4N85_RS07270	COG0758	DNA mediated transformation
E4N85_RS07280	COG4974	Belongs to the 'phage' integrase family
E4N85_RS07285	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4N85_RS07300	COG0772	Belongs to the SEDS family
E4N85_RS07305	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4N85_RS07315	COG0275	rRNA processing
E4N85_RS07320	COG2001	Belongs to the MraZ family
E4N85_RS07325	COG1505	serine-type exopeptidase activity
E4N85_RS07365	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4N85_RS07375	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E4N85_RS07395	COG1120	ATPase activity
E4N85_RS07400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N85_RS07405	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4N85_RS07410	COG1846	Transcriptional regulator
E4N85_RS07415	COG0500	methyltransferase
E4N85_RS07425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N85_RS07430	COG1120	ATPase activity
E4N85_RS07440	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4N85_RS07445	COG0459	protein refolding
E4N85_RS07460	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E4N85_RS07465	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4N85_RS07505	COG1366	Belongs to the anti-sigma-factor antagonist family
E4N85_RS07525	COG3033	Beta-eliminating lyase
E4N85_RS07550	COG0563	adenylate kinase activity
E4N85_RS07570	COG0779	Required for maturation of 30S ribosomal subunits
E4N85_RS07580	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E4N85_RS07585	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E4N85_RS07590	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4N85_RS07690	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4N85_RS07695	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4N85_RS07705	COG3330	Domain of unknown function (DUF4912)
E4N85_RS07720	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4N85_RS07730	COG3706	GGDEF domain
E4N85_RS07735	COG1102	Psort location Cytoplasmic, score
E4N85_RS07740	COG1561	YicC-like family, N-terminal region
E4N85_RS07750	COG0285	dihydrofolate synthase activity
E4N85_RS07755	COG0564	pseudouridine synthase activity
E4N85_RS07770	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4N85_RS07775	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4N85_RS07780	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4N85_RS07780	COG0426	domain, Protein
E4N85_RS07790	COG4608	Belongs to the ABC transporter superfamily
E4N85_RS07795	COG0444	Belongs to the ABC transporter superfamily
E4N85_RS07800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N85_RS07820	COG0601	transmembrane transport
E4N85_RS07825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N85_RS07830	COG0444	Belongs to the ABC transporter superfamily
E4N85_RS07835	COG4608	Belongs to the ABC transporter superfamily
E4N85_RS07855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4N85_RS07855	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4N85_RS07875	COG0534	Mate efflux family protein
E4N85_RS07880	COG0840	transmembrane signaling receptor activity
E4N85_RS07905	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N85_RS07915	COG0049	tRNA binding
E4N85_RS07920	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E4N85_RS07930	COG2832	Protein of unknown function (DUF454)
E4N85_RS07945	COG0756	dUTP diphosphatase activity
E4N85_RS07950	COG1185	polyribonucleotide nucleotidyltransferase activity
E4N85_RS07955	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E4N85_RS07960	COG0196	riboflavin kinase activity
E4N85_RS07970	COG0598	Magnesium transport protein CorA
E4N85_RS07975	COG0617	tRNA 3'-terminal CCA addition
E4N85_RS07990	COG0071	Belongs to the small heat shock protein (HSP20) family
E4N85_RS07995	COG0571	ribonuclease III activity
E4N85_RS08000	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4N85_RS08005	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4N85_RS08015	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4N85_RS08050	COG1067	ATP-dependent peptidase activity
E4N85_RS08060	COG2703	oxygen carrier activity
E4N85_RS08065	COG2183	response to ionizing radiation
E4N85_RS08075	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4N85_RS08085	COG3951	Flagellar rod assembly protein muramidase FlgJ
E4N85_RS08095	COG4786	Flagellar basal body rod
E4N85_RS08115	COG2084	Dehydrogenase
E4N85_RS08120	COG2116	formate transmembrane transporter activity
E4N85_RS08145	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4N85_RS08155	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4N85_RS08160	COG4166	transmembrane transport
E4N85_RS08165	COG4608	Belongs to the ABC transporter superfamily
E4N85_RS08170	COG0444	Belongs to the ABC transporter superfamily
E4N85_RS08180	COG4239	(ABC) transporter, permease
E4N85_RS08185	COG4174	ABC transporter (Permease)
E4N85_RS08200	COG0017	Asparaginyl-tRNA synthetase
E4N85_RS08205	COG1686	Belongs to the peptidase S11 family
E4N85_RS08225	COG2003	Belongs to the UPF0758 family
E4N85_RS08230	COG1040	competence protein
E4N85_RS08235	COG0018	arginyl-trna synthetase
E4N85_RS08250	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4N85_RS08265	COG1692	metallophosphoesterase
E4N85_RS08275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4N85_RS08285	COG0484	heat shock protein binding
E4N85_RS08290	COG2089	acid synthase
E4N85_RS08295	COG5341	Protein conserved in bacteria
E4N85_RS08300	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4N85_RS08305	COG0584	glycerophosphoryl diester phosphodiesterase
E4N85_RS08310	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4N85_RS08315	COG1704	LemA family
E4N85_RS08320	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4N85_RS08325	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4N85_RS08330	COG3845	ABC transporter
E4N85_RS08335	COG1744	ABC transporter substrate-binding protein PnrA-like
E4N85_RS08350	COG0148	phosphopyruvate hydratase activity
E4N85_RS08360	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N85_RS08365	COG0318	PFAM AMP-dependent synthetase and ligase
E4N85_RS08370	COG0791	NLP P60 protein
E4N85_RS08380	COG3735	TraB family
E4N85_RS08385	COG0116	Belongs to the methyltransferase superfamily
E4N85_RS08390	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4N85_RS08395	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4N85_RS08410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N85_RS08415	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4N85_RS08425	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4N85_RS08430	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4N85_RS08435	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4N85_RS08450	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4N85_RS08465	COG1132	(ABC) transporter
E4N85_RS08470	COG1132	(ABC) transporter
E4N85_RS08475	COG1132	(ABC) transporter
E4N85_RS08500	COG1132	(ABC) transporter
E4N85_RS08510	COG1129	ABC transporter
E4N85_RS08520	COG0210	DNA helicase
E4N85_RS08535	COG1129	ABC transporter
E4N85_RS08550	COG1132	(ABC) transporter
E4N85_RS08555	COG2375	cellular response to nickel ion
E4N85_RS08555	COG1132	(ABC) transporter
E4N85_RS08560	COG2207	Transcriptional regulator
E4N85_RS08570	COG4555	ABC transporter
E4N85_RS08585	COG2378	regulation of single-species biofilm formation
E4N85_RS08615	COG0335	large ribosomal subunit rRNA binding
E4N85_RS08620	COG0336	Belongs to the RNA methyltransferase TrmD family
E4N85_RS08625	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4N85_RS08630	COG1837	Belongs to the UPF0109 family
E4N85_RS08635	COG0228	four-way junction DNA binding
E4N85_RS08680	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4N85_RS08685	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E4N85_RS08690	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4N85_RS08695	COG0737	Belongs to the 5'-nucleotidase family
E4N85_RS08725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4N85_RS08730	COG1285	pathogenesis
E4N85_RS08745	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4N85_RS08750	COG1187	pseudouridine synthase activity
E4N85_RS08775	COG2197	response regulator
E4N85_RS08780	COG2137	regulation of response to DNA damage stimulus
E4N85_RS08790	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4N85_RS08815	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4N85_RS08825	COG0574	Belongs to the PEP-utilizing enzyme family
E4N85_RS08825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N85_RS08840	COG2304	oxidoreductase activity
E4N85_RS08850	COG1054	Belongs to the UPF0176 family
E4N85_RS08855	COG4656	Part of a membrane complex involved in electron transport
E4N85_RS08860	COG4658	electron transport chain
E4N85_RS08865	COG4659	FMN binding
E4N85_RS08870	COG4660	Part of a membrane complex involved in electron transport
E4N85_RS08875	COG4657	Part of a membrane complex involved in electron transport
E4N85_RS08895	COG1362	aminopeptidase activity
E4N85_RS08900	COG0445	tRNA wobble uridine modification
E4N85_RS08905	COG3422	double-strand break repair
E4N85_RS08910	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4N85_RS08915	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4N85_RS08935	COG1132	(ABC) transporter
E4N85_RS08990	COG1690	Belongs to the RtcB family
E4N85_RS09000	COG2910	NAD(P)H-binding
E4N85_RS09005	COG1959	2 iron, 2 sulfur cluster binding
E4N85_RS09030	COG1254	Belongs to the acylphosphatase family
E4N85_RS09055	COG0203	ribosomal protein L17
E4N85_RS09060	COG0202	RNA polymerase activity
E4N85_RS09065	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4N85_RS09070	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4N85_RS09075	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4N85_RS09085	COG0200	Binds to the 23S rRNA
E4N85_RS09090	COG1841	ribosomal large subunit assembly
E4N85_RS09095	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4N85_RS09100	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E4N85_RS09105	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4N85_RS09110	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4N85_RS09115	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E4N85_RS09120	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4N85_RS09125	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4N85_RS09130	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4N85_RS09135	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4N85_RS09140	COG0255	Belongs to the universal ribosomal protein uL29 family
E4N85_RS09145	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E4N85_RS09150	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4N85_RS09155	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4N85_RS09160	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E4N85_RS09165	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4N85_RS09170	COG0089	rRNA binding
E4N85_RS09175	COG0088	Forms part of the polypeptide exit tunnel
E4N85_RS09180	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4N85_RS09185	COG0051	transcription antitermination factor activity, RNA binding
E4N85_RS09190	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4N85_RS09220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N85_RS09225	COG1120	ATPase activity
E4N85_RS09230	COG1757	Na H antiporter
E4N85_RS09250	COG3118	belongs to the thioredoxin family
E4N85_RS09300	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4N85_RS09325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4N85_RS09400	COG0330	HflC and HflK could
E4N85_RS09415	COG1131	(ABC) transporter
E4N85_RS09455	COG1131	(ABC) transporter
E4N85_RS09460	COG0351	phosphomethylpyrimidine kinase
E4N85_RS09470	COG0482	sulfurtransferase activity
E4N85_RS09485	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4N85_RS09490	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4N85_RS09495	COG1028	Short-chain dehydrogenase reductase Sdr
E4N85_RS09500	COG0629	single-stranded DNA binding
E4N85_RS09505	COG1862	Preprotein translocase
E4N85_RS09510	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4N85_RS09515	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4N85_RS09520	COG1104	cysteine desulfurase activity
E4N85_RS09530	COG0425	Belongs to the sulfur carrier protein TusA family
E4N85_RS09560	COG3093	addiction module antidote protein HigA
E4N85_RS09565	COG3549	Plasmid maintenance system killer
E4N85_RS09570	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4N85_RS09580	COG0719	Fe-S assembly protein
E4N85_RS09585	COG0396	ATPase activity
E4N85_RS09590	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4N85_RS09590	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4N85_RS09590	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4N85_RS09590	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4N85_RS09595	COG2885	chlorophyll binding
E4N85_RS09605	COG4115	mRNA cleavage
E4N85_RS09630	COG2378	regulation of single-species biofilm formation
E4N85_RS09645	COG1136	(ABC) transporter
E4N85_RS09650	COG5002	protein histidine kinase activity
E4N85_RS09660	COG1473	amidohydrolase
E4N85_RS09675	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E4N85_RS09695	COG2201	protein-glutamate methylesterase activity
E4N85_RS09715	COG1137	ATPase activity
E4N85_RS09720	COG0193	aminoacyl-tRNA hydrolase activity
E4N85_RS09730	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4N85_RS09740	COG0601	transmembrane transport
E4N85_RS09745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N85_RS09750	COG0444	Belongs to the ABC transporter superfamily
E4N85_RS09755	COG4608	Belongs to the ABC transporter superfamily
E4N85_RS09765	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E4N85_RS09790	COG0484	heat shock protein binding
E4N85_RS09795	COG0443	Heat shock 70 kDa protein
E4N85_RS09800	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4N85_RS09805	COG0515	serine threonine protein kinase
E4N85_RS09805	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4N85_RS09820	COG1120	ATPase activity
E4N85_RS09845	COG0534	Mate efflux family protein
E4N85_RS09875	COG1192	Involved in chromosome partitioning
E4N85_RS09880	COG1475	DNA binding
E4N85_RS09900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4N85_RS09905	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4N85_RS09910	COG1028	Short-chain dehydrogenase reductase Sdr
E4N85_RS09915	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4N85_RS09935	COG0439	Biotin carboxylase
E4N85_RS09940	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4N85_RS09945	COG0825	malonyl-CoA metabolic process
E4N85_RS09950	COG2986	histidine ammonia-lyase
E4N85_RS09970	COG0701	Predicted permease
E4N85_RS09975	COG3689	TIGRFAM TIGR03943 family protein
E4N85_RS09980	COG0714	Associated with various cellular activities
E4N85_RS10015	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4N85_RS10020	COG0154	amidase activity
E4N85_RS10025	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4N85_RS10175	COG2369	cell adhesion
E4N85_RS10225	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4N85_RS10380	COG1309	transcriptional regulator
E4N85_RS10385	COG1131	(ABC) transporter
E4N85_RS10410	COG1136	(ABC) transporter
E4N85_RS10545	COG3041	Addiction module toxin RelE StbE family
E4N85_RS10600	COG1396	sequence-specific DNA binding
E4N85_RS10610	COG3550	peptidyl-serine autophosphorylation
E4N85_RS10620	COG3850	Histidine kinase
E4N85_RS10620	COG5002	protein histidine kinase activity
E4N85_RS10625	COG0745	RESPONSE REGULATOR receiver
E4N85_RS10650	COG4555	ABC transporter
E4N85_RS10690	COG1151	hydroxylamine reductase activity
E4N85_RS10705	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4N85_RS10710	COG1136	(ABC) transporter
E4N85_RS10710	COG0577	efflux transmembrane transporter activity
E4N85_RS10725	COG4115	mRNA cleavage
E4N85_RS10740	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4N85_RS10770	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4N85_RS10810	COG0813	purine-nucleoside phosphorylase activity
E4N85_RS10815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N85_RS10835	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
E4N85_RS10840	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4N85_RS10860	COG2235	arginine
E4N85_RS10865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4N85_RS10875	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4N85_RS10895	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4N85_RS10925	COG0343	queuine tRNA-ribosyltransferase activity
E4N85_RS10935	COG1381	Involved in DNA repair and RecF pathway recombination
E4N85_RS10945	COG0514	ATP-dependent DNA helicase (RecQ)
E4N85_RS10950	COG1592	Rubrerythrin
E4N85_RS10990	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4N85_RS10995	COG0501	Belongs to the peptidase M48B family
E4N85_RS11005	COG0543	2 iron, 2 sulfur cluster binding
E4N85_RS11035	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4N85_RS11050	COG0747	negative chemotaxis
E4N85_RS11055	COG4608	Belongs to the ABC transporter superfamily
E4N85_RS11060	COG0444	Belongs to the ABC transporter superfamily
E4N85_RS11065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N85_RS11080	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4N85_RS11095	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4N85_RS11110	COG1840	ABC-type Fe3 transport system, periplasmic component
E4N85_RS11115	COG4133	protoheme IX ABC transporter activity
E4N85_RS11155	COG3842	ATPase activity
E4N85_RS11160	COG0438	transferase activity, transferring glycosyl groups
E4N85_RS11165	COG1132	(ABC) transporter
E4N85_RS11170	COG2274	protein secretion by the type I secretion system
E4N85_RS11170	COG3271	cysteine-type peptidase activity
E4N85_RS11190	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4N85_RS11195	COG1132	(ABC) transporter
E4N85_RS11210	COG0786	glutamate:sodium symporter activity
E4N85_RS11215	COG1132	(ABC) transporter
E4N85_RS11220	COG1132	(ABC) transporter
E4N85_RS11245	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4N85_RS11255	COG0698	ribose 5-phosphate isomerase
E4N85_RS11260	COG0039	L-malate dehydrogenase activity
E4N85_RS11265	COG0534	Mate efflux family protein
E4N85_RS11270	COG0574	Belongs to the PEP-utilizing enzyme family
E4N85_RS11270	COG3848	Pyruvate phosphate dikinase
E4N85_RS11275	COG1309	transcriptional regulator
E4N85_RS11280	COG0840	transmembrane signaling receptor activity
E4N85_RS11285	COG0840	transmembrane signaling receptor activity
E4N85_RS11300	COG0728	peptidoglycan biosynthetic process
E4N85_RS11305	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4N85_RS11310	COG3588	fructose-bisphosphate aldolase
E4N85_RS11315	COG1309	transcriptional regulator
E4N85_RS11325	COG0363	glucosamine-6-phosphate deaminase activity
E4N85_RS11330	COG0628	permease
E4N85_RS11335	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4N85_RS11345	COG0534	Mate efflux family protein
E4N85_RS11350	COG1309	transcriptional regulator
E4N85_RS11360	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
E4N85_RS11365	COG1518	maintenance of DNA repeat elements
E4N85_RS11370	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
E4N85_RS11375	COG0514	ATP-dependent DNA helicase (RecQ)
E4N85_RS11400	COG4536	flavin adenine dinucleotide binding
E4N85_RS11405	COG4536	flavin adenine dinucleotide binding
E4N85_RS11410	COG0714	Associated with various cellular activities
E4N85_RS11425	COG1132	(ABC) transporter
E4N85_RS11440	COG0569	domain protein
E4N85_RS11445	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4N85_RS11450	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
E4N85_RS11470	COG0616	signal peptide processing
E4N85_RS11475	COG0012	GTP binding
E4N85_RS11500	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4N85_RS11505	COG0494	nUDIX hydrolase
E4N85_RS11520	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4N85_RS11525	COG0569	domain protein
E4N85_RS11535	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4N85_RS11565	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E4N85_RS11570	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N85_RS11585	COG1129	ABC transporter
E4N85_RS11615	COG2375	cellular response to nickel ion
E4N85_RS11615	COG1132	(ABC) transporter
E4N85_RS11620	COG1132	(ABC) transporter
E4N85_RS11660	COG1846	Transcriptional regulator
E4N85_RS11665	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4N85_RS11680	COG1129	ABC transporter
E4N85_RS11700	COG0733	neurotransmitter:sodium symporter activity
E4N85_RS11715	COG1222	aaa ATPase
E4N85_RS11725	COG3189	MarR family transcriptional regulator
E4N85_RS11730	COG1309	transcriptional regulator
E4N85_RS11735	COG1132	(ABC) transporter
E4N85_RS11740	COG1132	(ABC) transporter
E4N85_RS11745	COG1132	(ABC) transporter
E4N85_RS11750	COG1132	(ABC) transporter
E4N85_RS11775	COG1129	ABC transporter
E4N85_RS11785	COG1132	(ABC) transporter
E4N85_RS11795	COG1129	ABC transporter
E4N85_RS11810	COG1129	ABC transporter
E4N85_RS11825	COG1132	(ABC) transporter
E4N85_RS11830	COG2375	cellular response to nickel ion
E4N85_RS11830	COG1132	(ABC) transporter
E4N85_RS11865	COG3842	ATPase activity
E4N85_RS11870	COG3833	ABC-type maltose transport systems, permease component
E4N85_RS11875	COG1175	transmembrane transport
E4N85_RS11885	COG1418	mRNA catabolic process
E4N85_RS11895	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4N85_RS11900	COG0592	DNA-directed DNA polymerase activity
E4N85_RS11905	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4N85_RS12005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4N85_RS12020	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4N85_RS12025	COG1929	Belongs to the glycerate kinase type-1 family
E4N85_RS12030	COG2610	gluconate transmembrane transporter activity
E4N85_RS12045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4N85_RS12060	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4N85_RS12120	COG0730	response to heat
E4N85_RS12150	COG4208	sulfate ABC transporter
E4N85_RS12155	COG3839	Belongs to the ABC transporter superfamily
E4N85_RS12160	COG0840	transmembrane signaling receptor activity
E4N85_RS12165	COG0840	transmembrane signaling receptor activity
E4N85_RS12180	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
E4N85_RS12185	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E4N85_RS12190	COG1674	ftsk spoiiie
E4N85_RS12195	COG1968	undecaprenyl-diphosphatase activity
E4N85_RS12200	COG0419	ATPase involved in DNA repair
E4N85_RS12205	COG0420	3'-5' exonuclease activity
E4N85_RS12210	COG3290	protein histidine kinase activity
E4N85_RS12210	COG0840	transmembrane signaling receptor activity
E4N85_RS12220	COG1131	(ABC) transporter
E4N85_RS12240	COG0716	FMN binding
E4N85_RS12260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4N85_RS12285	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4N85_RS12300	COG4585	Histidine kinase
E4N85_RS12305	COG1473	amidohydrolase
E4N85_RS12320	COG1373	ATPase (AAA superfamily
E4N85_RS12335	COG4143	(ABC) transporter
E4N85_RS12350	COG0840	transmembrane signaling receptor activity
E4N85_RS12360	COG1823	symporter activity
E4N85_RS12365	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
E4N85_RS12365	COG0540	Belongs to the ATCase OTCase family
E4N85_RS12370	COG5001	Diguanylate cyclase
E4N85_RS12370	COG5002	protein histidine kinase activity
E4N85_RS12430	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
E4N85_RS12445	COG1774	PSP1 C-terminal conserved region
E4N85_RS12450	COG1728	Protein conserved in bacteria
E4N85_RS12460	COG0739	heme binding
E4N85_RS12480	COG0366	Alpha amylase catalytic
E4N85_RS12490	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4N85_RS12495	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E4N85_RS12515	COG0823	Involved in the tonB-independent uptake of proteins
E4N85_RS12515	COG4946	Tricorn protease homolog
E4N85_RS12515	COG1506	peptidase
E4N85_RS12545	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4N85_RS12550	COG0215	cysteine-tRNA ligase activity
E4N85_RS12565	COG1305	Transglutaminase-like
E4N85_RS12570	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4N85_RS12575	COG0569	domain protein
E4N85_RS12580	COG2887	Belongs to the helicase family. UvrD subfamily
E4N85_RS12585	COG1074	ATP-dependent DNA helicase activity
E4N85_RS12590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N85_RS12610	COG1012	belongs to the aldehyde dehydrogenase family
E4N85_RS12630	COG1830	Aldolase
E4N85_RS12635	COG1063	alcohol dehydrogenase
E4N85_RS12640	COG0531	amino acid
E4N85_RS12645	COG0196	riboflavin kinase activity
E4N85_RS12655	COG0826	peptidase U32
E4N85_RS12665	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4N85_RS12670	COG1509	lysine 2,3-aminomutase activity
E4N85_RS12675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4N85_RS12680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4N85_RS12695	COG0205	6-phosphofructokinase activity
E4N85_RS12730	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4N85_RS12740	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4N85_RS12745	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4N85_RS12750	COG1684	flagellar biosynthetic protein fliR
E4N85_RS12755	COG1987	bacterial-type flagellum assembly
E4N85_RS12780	COG1228	amidohydrolase
E4N85_RS12795	COG0457	Tetratricopeptide repeat
E4N85_RS12800	COG0280	phosphate acetyltransferase
E4N85_RS12810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4N85_RS12815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4N85_RS12830	COG0537	adenosine 5'-monophosphoramidase activity
E4N85_RS12865	COG1132	(ABC) transporter
E4N85_RS12875	COG2801	Transposase and inactivated derivatives
E4N85_RS12895	COG2801	Transposase and inactivated derivatives
E4N85_RS12905	COG1472	Belongs to the glycosyl hydrolase 3 family
E4N85_RS12925	COG0423	glycine-tRNA ligase activity
E4N85_RS12930	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E4N85_RS12940	COG1363	Peptidase, m42
E4N85_RS12960	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4N85_RS12965	COG1966	Carbon starvation protein
E4N85_RS12970	COG0450	alkyl hydroperoxide reductase
E4N85_RS12975	COG0494	nUDIX hydrolase
E4N85_RS12985	COG2217	Heavy metal translocating P-type atpase
E4N85_RS12995	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4N85_RS13015	COG0187	DNA topoisomerase II activity