locus-tag	class	description
C5N99_RS00005	COG0732	type I restriction modification DNA specificity domain
C5N99_RS00010	COG0732	type I restriction modification DNA specificity domain
C5N99_RS00015	COG4974	Belongs to the 'phage' integrase family
C5N99_RS00030	COG0732	type I restriction modification DNA specificity domain
C5N99_RS00050	COG2703	oxygen carrier activity
C5N99_RS00105	COG0813	purine-nucleoside phosphorylase activity
C5N99_RS00130	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C5N99_RS00135	COG3639	organic phosphonate transmembrane transporter activity
C5N99_RS00155	COG1187	pseudouridine synthase activity
C5N99_RS00160	COG0840	transmembrane signaling receptor activity
C5N99_RS00180	COG1129	ABC transporter
C5N99_RS00185	COG1609	Transcriptional regulator
C5N99_RS00195	COG0546	phosphoglycolate phosphatase activity
C5N99_RS00230	COG1253	flavin adenine dinucleotide binding
C5N99_RS00235	COG0840	transmembrane signaling receptor activity
C5N99_RS00250	COG0756	dUTP diphosphatase activity
C5N99_RS00255	COG1185	polyribonucleotide nucleotidyltransferase activity
C5N99_RS00265	COG0196	riboflavin kinase activity
C5N99_RS00275	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C5N99_RS00280	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C5N99_RS00290	COG0779	Required for maturation of 30S ribosomal subunits
C5N99_RS00310	COG1713	HD superfamily hydrolase involved in NAD metabolism
C5N99_RS00310	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C5N99_RS00320	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C5N99_RS00325	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C5N99_RS00335	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C5N99_RS00340	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C5N99_RS00345	COG0571	ribonuclease III activity
C5N99_RS00350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5N99_RS00355	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C5N99_RS00370	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C5N99_RS00385	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C5N99_RS00400	COG1921	L-seryl-tRNASec selenium transferase activity
C5N99_RS00415	COG0840	transmembrane signaling receptor activity
C5N99_RS00430	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C5N99_RS00440	COG1012	belongs to the aldehyde dehydrogenase family
C5N99_RS00445	COG1960	acyl-CoA dehydrogenase activity
C5N99_RS00465	COG1598	PFAM Uncharacterised protein family UPF0150
C5N99_RS00500	COG2887	Belongs to the helicase family. UvrD subfamily
C5N99_RS00510	COG0300	oxidoreductase activity
C5N99_RS00540	COG0681	Belongs to the peptidase S26 family
C5N99_RS00550	COG0740	serine-type endopeptidase activity
C5N99_RS00555	COG0556	nucleotide-excision repair
C5N99_RS00565	COG0709	Synthesizes selenophosphate from selenide and ATP
C5N99_RS00590	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
C5N99_RS00605	COG1744	ABC transporter substrate-binding protein PnrA-like
C5N99_RS00610	COG3845	ABC transporter
C5N99_RS00615	COG4603	Belongs to the binding-protein-dependent transport system permease family
C5N99_RS00620	COG1079	Belongs to the binding-protein-dependent transport system permease family
C5N99_RS00635	COG2361	Protein of unknown function DUF86
C5N99_RS00670	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C5N99_RS00675	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C5N99_RS00680	COG3706	GGDEF domain
C5N99_RS00680	COG2203	Gaf domain
C5N99_RS00680	COG4251	negative regulation of phosphorylation
C5N99_RS00680	COG5001	Diguanylate cyclase
C5N99_RS00685	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C5N99_RS00690	COG0205	6-phosphofructokinase activity
C5N99_RS00695	COG0124	histidyl-tRNA synthetase
C5N99_RS00710	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C5N99_RS00750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C5N99_RS00765	COG0395	ABC-type sugar transport system, permease component
C5N99_RS00770	COG1175	transmembrane transport
C5N99_RS00780	COG3437	response regulator, receiver
C5N99_RS00780	COG2770	Histidine kinase
C5N99_RS00785	COG1214	PFAM Peptidase M22, glycoprotease
C5N99_RS00790	COG0802	atpase or kinase
C5N99_RS00795	COG0564	pseudouridine synthase activity
C5N99_RS00805	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C5N99_RS00820	COG0297	glycogen (starch) synthase activity
C5N99_RS00850	COG1027	Aspartate ammonia-lyase
C5N99_RS00855	COG0295	cytidine deaminase activity
C5N99_RS00865	COG0739	heme binding
C5N99_RS00905	COG3876	Protein conserved in bacteria
C5N99_RS00920	COG2239	Acts as a magnesium transporter
C5N99_RS00925	COG0170	dolichyl monophosphate biosynthetic process
C5N99_RS00945	COG0346	lactoylglutathione lyase activity
C5N99_RS00960	COG2252	PERMEase
C5N99_RS00975	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C5N99_RS00980	COG0443	Heat shock 70 kDa protein
C5N99_RS00985	COG0484	heat shock protein binding
C5N99_RS01005	COG1715	Restriction endonuclease
C5N99_RS01010	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C5N99_RS01015	COG0483	inositol monophosphate 1-phosphatase activity
C5N99_RS01020	COG3842	ATPase activity
C5N99_RS01035	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C5N99_RS01035	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C5N99_RS01035	COG1013	pyruvate-flavodoxin oxidoreductase activity
C5N99_RS01035	COG0674	pyruvate-flavodoxin oxidoreductase activity
C5N99_RS01045	COG2195	Cleaves the N-terminal amino acid of tripeptides
C5N99_RS01050	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C5N99_RS01065	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C5N99_RS01070	COG3549	Plasmid maintenance system killer
C5N99_RS01085	COG0318	PFAM AMP-dependent synthetase and ligase
C5N99_RS01095	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C5N99_RS01110	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
C5N99_RS01120	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
C5N99_RS01125	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
C5N99_RS01130	COG1394	ATPase activity, coupled to movement of substances
C5N99_RS01135	COG1269	ATP hydrolysis coupled proton transport
C5N99_RS01145	COG0840	transmembrane signaling receptor activity
C5N99_RS01155	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C5N99_RS01165	COG0840	transmembrane signaling receptor activity
C5N99_RS01185	COG1199	ATP-dependent helicase activity
C5N99_RS01195	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C5N99_RS01205	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C5N99_RS01220	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C5N99_RS01225	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C5N99_RS01230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5N99_RS01240	COG0840	transmembrane signaling receptor activity
C5N99_RS01260	COG1475	DNA binding
C5N99_RS01265	COG1192	Involved in chromosome partitioning
C5N99_RS01270	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C5N99_RS01285	COG0427	acetyl-CoA hydrolase
C5N99_RS01290	COG1024	Enoyl-CoA hydratase
C5N99_RS01295	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5N99_RS01375	COG2244	polysaccharide biosynthetic process
C5N99_RS01400	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C5N99_RS01435	COG1373	ATPase (AAA superfamily
C5N99_RS01465	COG1362	aminopeptidase activity
C5N99_RS01470	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C5N99_RS01485	COG2217	Heavy metal translocating P-type atpase
C5N99_RS01495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5N99_RS01515	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5N99_RS01550	COG0670	Belongs to the BI1 family
C5N99_RS01555	COG0180	Tryptophanyl-tRNA synthetase
C5N99_RS01560	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C5N99_RS01610	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C5N99_RS01630	COG1191	sigma factor activity
C5N99_RS01640	COG0840	transmembrane signaling receptor activity
C5N99_RS01645	COG0433	COG0433 Predicted ATPase
C5N99_RS01650	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C5N99_RS01655	COG1722	exodeoxyribonuclease VII activity
C5N99_RS01750	COG0733	neurotransmitter:sodium symporter activity
C5N99_RS01755	COG0457	Tetratricopeptide repeat
C5N99_RS01760	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C5N99_RS01765	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
C5N99_RS01775	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5N99_RS01780	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C5N99_RS01795	COG0058	SHG alpha-glucan phosphorylase activity
C5N99_RS01805	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C5N99_RS01815	COG1040	competence protein
C5N99_RS01820	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C5N99_RS01825	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C5N99_RS01830	COG1862	Preprotein translocase
C5N99_RS01835	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C5N99_RS01845	COG1847	R3H domain protein
C5N99_RS01850	COG0706	membrane insertase activity
C5N99_RS01855	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C5N99_RS01900	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
C5N99_RS01905	COG1472	Belongs to the glycosyl hydrolase 3 family
C5N99_RS01910	COG0492	ferredoxin-NADP+ reductase activity
C5N99_RS01915	COG0280	phosphate acetyltransferase
C5N99_RS01935	COG0459	protein refolding
C5N99_RS01950	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C5N99_RS01955	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C5N99_RS01960	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C5N99_RS01960	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C5N99_RS01975	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C5N99_RS01990	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C5N99_RS02000	COG0728	peptidoglycan biosynthetic process
C5N99_RS02015	COG0803	Belongs to the bacterial solute-binding protein 9 family
C5N99_RS02020	COG0420	3'-5' exonuclease activity
C5N99_RS02025	COG0419	ATPase involved in DNA repair
C5N99_RS02035	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C5N99_RS02060	COG0588	phosphoglycerate mutase activity
C5N99_RS02065	COG0564	pseudouridine synthase activity
C5N99_RS02095	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C5N99_RS02120	COG2378	regulation of single-species biofilm formation
C5N99_RS02145	COG4443	Transcriptional Coactivator p15 (PC4)
C5N99_RS02150	COG0840	transmembrane signaling receptor activity
C5N99_RS02160	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C5N99_RS02160	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C5N99_RS02165	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C5N99_RS02185	COG1309	transcriptional regulator
C5N99_RS02235	COG5433	transposase activity
C5N99_RS02240	COG1647	Serine aminopeptidase, S33
C5N99_RS02250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5N99_RS02255	COG1028	Short-chain dehydrogenase reductase Sdr
C5N99_RS02285	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C5N99_RS02290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C5N99_RS02315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C5N99_RS02320	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C5N99_RS02325	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5N99_RS02330	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C5N99_RS02335	COG2878	Part of a membrane complex involved in electron transport
C5N99_RS02335	COG1245	4Fe-4S binding domain
C5N99_RS02340	COG4657	Part of a membrane complex involved in electron transport
C5N99_RS02345	COG4660	Part of a membrane complex involved in electron transport
C5N99_RS02350	COG4659	FMN binding
C5N99_RS02355	COG4658	electron transport chain
C5N99_RS02360	COG4656	Part of a membrane complex involved in electron transport
C5N99_RS02365	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C5N99_RS02380	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C5N99_RS02385	COG0825	malonyl-CoA metabolic process
C5N99_RS02395	COG0540	Belongs to the ATCase OTCase family
C5N99_RS02400	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
C5N99_RS02405	COG0543	2 iron, 2 sulfur cluster binding
C5N99_RS02410	COG0167	dihydroorotate dehydrogenase activity
C5N99_RS02415	COG0284	orotidine-5'-phosphate decarboxylase activity
C5N99_RS02420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C5N99_RS02425	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C5N99_RS02435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5N99_RS02445	COG0613	PHP domain protein
C5N99_RS02455	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
C5N99_RS02480	COG1193	negative regulation of DNA recombination
C5N99_RS02490	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C5N99_RS02535	COG0629	single-stranded DNA binding
C5N99_RS02540	COG0281	malic enzyme
C5N99_RS02545	COG0039	L-malate dehydrogenase activity
C5N99_RS02600	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C5N99_RS02610	COG0513	Belongs to the DEAD box helicase family
C5N99_RS02625	COG0395	ABC-type sugar transport system, permease component
C5N99_RS02630	COG1175	transmembrane transport
C5N99_RS02650	COG1070	Carbohydrate kinase
C5N99_RS02665	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5N99_RS02675	COG1879	ABC-type sugar transport system periplasmic component
C5N99_RS02695	COG2011	ABC-type metal ion transport system permease component
C5N99_RS02705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5N99_RS02710	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C5N99_RS02715	COG3850	Histidine kinase
C5N99_RS02715	COG5002	protein histidine kinase activity
C5N99_RS02735	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C5N99_RS02735	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C5N99_RS02745	COG0351	phosphomethylpyrimidine kinase
C5N99_RS02785	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
C5N99_RS02835	COG0640	Transcriptional regulator
C5N99_RS02840	COG2217	Heavy metal translocating P-type atpase
C5N99_RS02845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C5N99_RS02890	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C5N99_RS02900	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C5N99_RS02930	COG3340	Belongs to the peptidase S51 family
C5N99_RS02995	COG0783	Belongs to the Dps family
C5N99_RS03005	COG0793	Belongs to the peptidase S41A family
C5N99_RS03025	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C5N99_RS03030	COG0840	transmembrane signaling receptor activity
C5N99_RS03040	COG0203	ribosomal protein L17
C5N99_RS03045	COG0202	RNA polymerase activity
C5N99_RS03050	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C5N99_RS03060	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C5N99_RS03070	COG0200	Binds to the 23S rRNA
C5N99_RS03080	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C5N99_RS03090	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C5N99_RS03095	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C5N99_RS03105	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C5N99_RS03110	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C5N99_RS03115	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C5N99_RS03120	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C5N99_RS03125	COG0255	Belongs to the universal ribosomal protein uL29 family
C5N99_RS03135	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C5N99_RS03140	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C5N99_RS03150	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C5N99_RS03155	COG0089	rRNA binding
C5N99_RS03160	COG0088	Forms part of the polypeptide exit tunnel
C5N99_RS03165	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C5N99_RS03170	COG0051	transcription antitermination factor activity, RNA binding
C5N99_RS03175	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C5N99_RS03190	COG0521	Mo-molybdopterin cofactor biosynthetic process
C5N99_RS03195	COG0725	ABC transporter, periplasmic molybdate-binding protein
C5N99_RS03200	COG4149	molybdate abc transporter
C5N99_RS03260	COG0741	lytic transglycosylase activity
C5N99_RS03265	COG1968	undecaprenyl-diphosphatase activity
C5N99_RS03270	COG1674	ftsk spoiiie
C5N99_RS03295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5N99_RS03300	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C5N99_RS03305	COG0084	hydrolase, TatD family'
C5N99_RS03315	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C5N99_RS03375	COG0714	Associated with various cellular activities
C5N99_RS03405	COG0826	peptidase U32
C5N99_RS03415	COG0822	iron-sulfur transferase activity
C5N99_RS03425	COG2255	four-way junction helicase activity
C5N99_RS03435	COG0445	tRNA wobble uridine modification
C5N99_RS03445	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C5N99_RS03460	COG1757	Na H antiporter
C5N99_RS03465	COG2203	Gaf domain
C5N99_RS03465	COG2199	diguanylate cyclase activity
C5N99_RS03470	COG3706	GGDEF domain
C5N99_RS03545	COG1054	Belongs to the UPF0176 family
C5N99_RS03550	COG0024	Methionine aminopeptidase
C5N99_RS03555	COG0484	heat shock protein binding
C5N99_RS03575	COG0318	PFAM AMP-dependent synthetase and ligase
C5N99_RS03575	COG0204	Acyl-transferase
C5N99_RS03585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5N99_RS03610	COG3041	Addiction module toxin RelE StbE family
C5N99_RS03615	COG2986	histidine ammonia-lyase
C5N99_RS03640	COG2801	Transposase and inactivated derivatives
C5N99_RS03655	COG1028	Short-chain dehydrogenase reductase Sdr
C5N99_RS03660	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5N99_RS03665	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C5N99_RS03680	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C5N99_RS03715	COG5433	transposase activity
C5N99_RS03750	COG0739	heme binding
C5N99_RS03775	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C5N99_RS03780	COG1129	ABC transporter
C5N99_RS03805	COG1917	Cupin 2, conserved barrel domain protein
C5N99_RS03805	COG4977	sequence-specific DNA binding
C5N99_RS03810	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C5N99_RS03865	COG1337	RAMP superfamily
C5N99_RS03890	COG1518	maintenance of DNA repeat elements
C5N99_RS03895	COG1401	restriction endodeoxyribonuclease activity
C5N99_RS03915	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C5N99_RS03965	COG2089	acid synthase
C5N99_RS03970	COG0592	DNA-directed DNA polymerase activity
C5N99_RS03975	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C5N99_RS04000	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C5N99_RS04045	COG2378	regulation of single-species biofilm formation
C5N99_RS04055	COG0545	Peptidyl-prolyl cis-trans isomerase
C5N99_RS04060	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C5N99_RS04080	COG0739	heme binding
C5N99_RS04085	COG1686	Belongs to the peptidase S11 family
C5N99_RS04105	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C5N99_RS04110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5N99_RS04135	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C5N99_RS04185	COG2204	response regulator
C5N99_RS04190	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C5N99_RS04195	COG1028	Short-chain dehydrogenase reductase Sdr
C5N99_RS04205	COG0516	GMP reductase activity
C5N99_RS04205	COG0517	IMP dehydrogenase activity
C5N99_RS04210	COG0205	6-phosphofructokinase activity
C5N99_RS04220	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C5N99_RS04220	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C5N99_RS04225	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C5N99_RS04230	COG0423	glycine-tRNA ligase activity
C5N99_RS04240	COG0584	glycerophosphoryl diester phosphodiesterase
C5N99_RS04305	COG2183	response to ionizing radiation
C5N99_RS04320	COG0012	GTP binding
C5N99_RS04325	COG0326	Molecular chaperone. Has ATPase activity
C5N99_RS04330	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C5N99_RS04345	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C5N99_RS04350	COG1120	ATPase activity
C5N99_RS04355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5N99_RS04395	COG0156	8-amino-7-oxononanoate synthase activity
C5N99_RS04400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5N99_RS04425	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C5N99_RS04430	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C5N99_RS04435	COG1114	Component of the transport system for branched-chain amino acids
C5N99_RS04440	COG0840	transmembrane signaling receptor activity
C5N99_RS04445	COG0739	heme binding
C5N99_RS04455	COG0237	dephospho-CoA kinase activity
C5N99_RS04475	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C5N99_RS04480	COG4452	Inner membrane protein CreD
C5N99_RS04495	COG1640	4-alpha-glucanotransferase
C5N99_RS04510	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5N99_RS04510	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5N99_RS04565	COG1983	PspC domain protein
C5N99_RS04575	COG1695	Transcriptional regulator
C5N99_RS04580	COG1121	(ABC) transporter
C5N99_RS04585	COG1639	'signal transduction protein
C5N99_RS04590	COG0543	2 iron, 2 sulfur cluster binding
C5N99_RS04605	COG0733	neurotransmitter:sodium symporter activity
C5N99_RS04620	COG0425	Belongs to the sulfur carrier protein TusA family
C5N99_RS04635	COG1879	ABC-type sugar transport system periplasmic component
C5N99_RS04650	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C5N99_RS04650	COG0438	transferase activity, transferring glycosyl groups
C5N99_RS04655	COG0511	ligase activity, forming carbon-carbon bonds
C5N99_RS04655	COG5016	pyruvate
C5N99_RS04685	COG1131	(ABC) transporter
C5N99_RS04705	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C5N99_RS04740	COG4656	Part of a membrane complex involved in electron transport
C5N99_RS04750	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
C5N99_RS04755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C5N99_RS04770	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C5N99_RS04775	COG3608	succinylglutamate desuccinylase aspartoacylase
C5N99_RS04775	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C5N99_RS04795	COG0488	(ABC) transporter
C5N99_RS04800	COG1115	amino acid carrier protein
C5N99_RS04805	COG2195	Cleaves the N-terminal amino acid of tripeptides
C5N99_RS04810	COG3437	response regulator, receiver
C5N99_RS04815	COG1671	Belongs to the UPF0178 family
C5N99_RS04820	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
C5N99_RS04835	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C5N99_RS04935	COG0701	Predicted permease
C5N99_RS04940	COG0116	Belongs to the methyltransferase superfamily
C5N99_RS04965	COG0542	response to heat
C5N99_RS04985	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C5N99_RS04995	COG0450	alkyl hydroperoxide reductase
C5N99_RS05020	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C5N99_RS05040	COG3177	Filamentation induced by cAMP protein fic
C5N99_RS05055	COG4942	peptidase
C5N99_RS05060	COG1079	Belongs to the binding-protein-dependent transport system permease family
C5N99_RS05065	COG4603	Belongs to the binding-protein-dependent transport system permease family
C5N99_RS05070	COG1129	ABC transporter
C5N99_RS05075	COG1744	ABC transporter substrate-binding protein PnrA-like
C5N99_RS05090	COG3842	ATPase activity
C5N99_RS05095	COG1176	ABC-type spermidine putrescine transport system, permease component I
C5N99_RS05100	COG1177	transmembrane transport
C5N99_RS05125	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C5N99_RS05130	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C5N99_RS05140	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C5N99_RS05145	COG4750	Nucleotidyl transferase
C5N99_RS05150	COG1129	ABC transporter
C5N99_RS05170	COG2211	Major facilitator Superfamily
C5N99_RS05185	COG0071	Belongs to the small heat shock protein (HSP20) family
C5N99_RS05195	COG0716	FMN binding
C5N99_RS05205	COG1956	GAF domain-containing protein
C5N99_RS05220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5N99_RS05225	COG1136	(ABC) transporter
C5N99_RS05240	COG0561	phosphatase activity
C5N99_RS05250	COG0577	efflux transmembrane transporter activity
C5N99_RS05255	COG1136	(ABC) transporter
C5N99_RS05255	COG0577	efflux transmembrane transporter activity
C5N99_RS05295	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5N99_RS05305	COG1132	(ABC) transporter
C5N99_RS05335	COG2815	serine threonine protein kinase
C5N99_RS05335	COG0515	serine threonine protein kinase
C5N99_RS05345	COG1002	Type II restriction enzyme, methylase subunits
C5N99_RS05370	COG1132	(ABC) transporter
C5N99_RS05380	COG1162	GTPase activity
C5N99_RS05385	COG1309	transcriptional regulator
C5N99_RS05390	COG1132	(ABC) transporter
C5N99_RS05395	COG1132	(ABC) transporter
C5N99_RS05400	COG1132	(ABC) transporter
C5N99_RS05405	COG1132	(ABC) transporter
C5N99_RS05410	COG1129	ABC transporter
C5N99_RS05425	COG1132	(ABC) transporter
C5N99_RS05430	COG1132	(ABC) transporter
C5N99_RS05430	COG2375	cellular response to nickel ion
C5N99_RS05435	COG2207	Transcriptional regulator
C5N99_RS05435	COG4753	response regulator
C5N99_RS05450	COG1129	ABC transporter
C5N99_RS05475	COG1132	(ABC) transporter
C5N99_RS05480	COG1132	(ABC) transporter
C5N99_RS05510	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C5N99_RS05525	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C5N99_RS05540	COG0653	protein targeting
C5N99_RS05555	COG1102	Psort location Cytoplasmic, score
C5N99_RS05575	COG0534	Mate efflux family protein
C5N99_RS05590	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C5N99_RS05630	COG0544	peptidyl-prolyl cis-trans isomerase activity
C5N99_RS05635	COG0740	serine-type endopeptidase activity
C5N99_RS05640	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C5N99_RS05650	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C5N99_RS05670	COG0395	ABC-type sugar transport system, permease component
C5N99_RS05675	COG4209	transmembrane transport
C5N99_RS05705	COG1129	ABC transporter
C5N99_RS05730	COG2267	carboxylic ester hydrolase activity
C5N99_RS05745	COG0481	GTPase activity
C5N99_RS05760	COG0018	arginyl-trna synthetase
C5N99_RS05765	COG2235	arginine
C5N99_RS05770	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C5N99_RS05775	COG0549	Belongs to the carbamate kinase family
C5N99_RS05780	COG1288	antiporter activity
C5N99_RS05790	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C5N99_RS05820	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C5N99_RS05825	COG0017	Asparaginyl-tRNA synthetase
C5N99_RS05840	COG1733	regulation of RNA biosynthetic process
C5N99_RS05880	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C5N99_RS05895	COG3118	belongs to the thioredoxin family
C5N99_RS05900	COG1692	metallophosphoesterase
C5N99_RS05905	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C5N99_RS05915	COG0719	Fe-S assembly protein
C5N99_RS05945	COG1570	exodeoxyribonuclease VII activity
C5N99_RS05955	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C5N99_RS05965	COG1744	ABC transporter substrate-binding protein PnrA-like
C5N99_RS05970	COG3845	ABC transporter
C5N99_RS05980	COG1079	Belongs to the binding-protein-dependent transport system permease family
C5N99_RS05990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5N99_RS05995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5N99_RS06005	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C5N99_RS06020	COG1879	ABC-type sugar transport system periplasmic component
C5N99_RS06025	COG1129	ABC transporter
C5N99_RS06030	COG4211	Belongs to the binding-protein-dependent transport system permease family
C5N99_RS06050	COG1309	transcriptional regulator
C5N99_RS06055	COG0574	Belongs to the PEP-utilizing enzyme family
C5N99_RS06055	COG3848	Pyruvate phosphate dikinase
C5N99_RS06060	COG0534	Mate efflux family protein
C5N99_RS06065	COG0668	transmembrane transport
C5N99_RS06075	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C5N99_RS06080	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
C5N99_RS06125	COG1418	mRNA catabolic process
C5N99_RS06130	COG0457	Tetratricopeptide repeat
C5N99_RS06135	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C5N99_RS06160	COG0494	nUDIX hydrolase
C5N99_RS06175	COG0681	Belongs to the peptidase S26 family
C5N99_RS06180	COG0768	penicillin binding
C5N99_RS06185	COG2604	Protein of unknown function DUF115
C5N99_RS06220	COG1254	Belongs to the acylphosphatase family
C5N99_RS06265	COG1181	Belongs to the D-alanine--D-alanine ligase family
C5N99_RS06270	COG1966	Carbon starvation protein
C5N99_RS06330	COG0402	S-adenosylhomocysteine deaminase activity
C5N99_RS06335	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C5N99_RS06340	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C5N99_RS06345	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C5N99_RS06360	COG0826	peptidase U32
C5N99_RS06375	COG0601	transmembrane transport
C5N99_RS06380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5N99_RS06385	COG0444	Belongs to the ABC transporter superfamily
C5N99_RS06390	COG4608	Belongs to the ABC transporter superfamily
C5N99_RS06395	COG0616	signal peptide processing
C5N99_RS06425	COG1129	ABC transporter
C5N99_RS06455	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C5N99_RS06460	COG2801	Transposase and inactivated derivatives
C5N99_RS06465	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C5N99_RS06480	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C5N99_RS06485	COG1438	arginine binding
C5N99_RS06515	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C5N99_RS06525	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C5N99_RS06530	COG0250	Participates in transcription elongation, termination and antitermination
C5N99_RS06535	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C5N99_RS06540	COG0081	regulation of translation
C5N99_RS06545	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C5N99_RS06550	COG0222	ribosome binding
C5N99_RS06555	COG0085	RNA polymerase activity
C5N99_RS06570	COG0049	tRNA binding
C5N99_RS06585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5N99_RS06595	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C5N99_RS06605	COG0217	transcriptional regulatory protein
C5N99_RS06645	COG0587	DNA-directed DNA polymerase activity
C5N99_RS06655	COG0762	integral membrane protein
C5N99_RS06665	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C5N99_RS06670	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C5N99_RS06675	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C5N99_RS06690	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
C5N99_RS06695	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
C5N99_RS06700	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5N99_RS06725	COG1774	PSP1 C-terminal conserved region
C5N99_RS06740	COG0739	heme binding
C5N99_RS06750	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C5N99_RS06755	COG2911	Protein conserved in bacteria
C5N99_RS06760	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5N99_RS06770	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C5N99_RS06780	COG0739	heme binding
C5N99_RS06810	COG2502	aspartate--ammonia ligase
C5N99_RS06820	COG0301	tRNA thio-modification
C5N99_RS06845	COG0322	excinuclease ABC activity
C5N99_RS06880	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C5N99_RS06925	COG1254	Belongs to the acylphosphatase family
C5N99_RS06970	COG1181	Belongs to the D-alanine--D-alanine ligase family
C5N99_RS06975	COG1966	Carbon starvation protein
C5N99_RS07035	COG0402	S-adenosylhomocysteine deaminase activity
C5N99_RS07040	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C5N99_RS07045	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C5N99_RS07050	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C5N99_RS07065	COG0826	peptidase U32
C5N99_RS07080	COG0601	transmembrane transport
C5N99_RS07085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5N99_RS07090	COG0444	Belongs to the ABC transporter superfamily
C5N99_RS07095	COG4608	Belongs to the ABC transporter superfamily
C5N99_RS07100	COG0616	signal peptide processing
C5N99_RS07130	COG1129	ABC transporter
C5N99_RS07160	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C5N99_RS07165	COG2801	Transposase and inactivated derivatives
C5N99_RS07170	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C5N99_RS07185	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C5N99_RS07190	COG1438	arginine binding
C5N99_RS07220	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C5N99_RS07230	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C5N99_RS07235	COG0250	Participates in transcription elongation, termination and antitermination
C5N99_RS07240	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C5N99_RS07245	COG0081	regulation of translation
C5N99_RS07250	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C5N99_RS07255	COG0222	ribosome binding
C5N99_RS07260	COG0085	RNA polymerase activity
C5N99_RS07275	COG0049	tRNA binding
C5N99_RS07290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5N99_RS07300	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C5N99_RS07310	COG0217	transcriptional regulatory protein
C5N99_RS07350	COG0587	DNA-directed DNA polymerase activity
C5N99_RS07360	COG0762	integral membrane protein
C5N99_RS07370	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C5N99_RS07375	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C5N99_RS07380	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C5N99_RS07395	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
C5N99_RS07400	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
C5N99_RS07405	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5N99_RS07430	COG1774	PSP1 C-terminal conserved region
C5N99_RS07445	COG0739	heme binding
C5N99_RS07455	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C5N99_RS07460	COG2911	Protein conserved in bacteria
C5N99_RS07465	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5N99_RS07475	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C5N99_RS07485	COG0739	heme binding
C5N99_RS07515	COG2502	aspartate--ammonia ligase
C5N99_RS07525	COG0301	tRNA thio-modification
C5N99_RS07550	COG0322	excinuclease ABC activity
C5N99_RS07585	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C5N99_RS07630	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C5N99_RS07645	COG2801	Transposase and inactivated derivatives
C5N99_RS07650	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C5N99_RS07655	COG0363	glucosamine-6-phosphate deaminase activity
C5N99_RS07660	COG0628	permease
C5N99_RS07665	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C5N99_RS07670	COG0328	RNA-DNA hybrid ribonuclease activity
C5N99_RS07675	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C5N99_RS07685	COG1175	transmembrane transport
C5N99_RS07690	COG0395	ABC-type sugar transport system, permease component
C5N99_RS07720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5N99_RS07735	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C5N99_RS07735	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C5N99_RS07755	COG1598	PFAM Uncharacterised protein family UPF0150
C5N99_RS07770	COG0737	Belongs to the 5'-nucleotidase family
C5N99_RS07780	COG0537	adenosine 5'-monophosphoramidase activity
C5N99_RS07785	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C5N99_RS07790	COG2088	sporulation resulting in formation of a cellular spore
C5N99_RS07800	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C5N99_RS07810	COG0457	Tetratricopeptide repeat
C5N99_RS07815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5N99_RS07830	COG0840	transmembrane signaling receptor activity
C5N99_RS07840	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5N99_RS07845	COG0786	glutamate:sodium symporter activity
C5N99_RS07855	COG4770	biotin carboxylase activity
C5N99_RS07860	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
C5N99_RS07865	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C5N99_RS07870	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C5N99_RS07875	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C5N99_RS07885	COG1924	4 iron, 4 sulfur cluster binding
C5N99_RS07890	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
C5N99_RS07895	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
C5N99_RS07905	COG0735	belongs to the Fur family
C5N99_RS07920	COG0494	nUDIX hydrolase
C5N99_RS07945	COG1480	7TM receptor with intracellular HD hydrolase
C5N99_RS07950	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C5N99_RS07980	COG0426	domain, Protein
C5N99_RS07980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C5N99_RS07985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5N99_RS07995	COG0318	PFAM AMP-dependent synthetase and ligase
C5N99_RS08000	COG1283	sodium-dependent phosphate transmembrane transporter activity
C5N99_RS08005	COG0574	Belongs to the PEP-utilizing enzyme family
C5N99_RS08005	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5N99_RS08025	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
C5N99_RS08035	COG1619	proteins homologs of microcin C7 resistance protein MccF
C5N99_RS08060	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C5N99_RS08070	COG0126	phosphoglycerate kinase activity
C5N99_RS08110	COG2201	protein-glutamate methylesterase activity
C5N99_RS08125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5N99_RS08130	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C5N99_RS08135	COG0215	cysteine-tRNA ligase activity
C5N99_RS08150	COG1305	Transglutaminase-like
C5N99_RS08155	COG0528	UMP kinase activity
C5N99_RS08160	COG0484	heat shock protein binding
C5N99_RS08165	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C5N99_RS08170	COG2801	Transposase and inactivated derivatives
C5N99_RS08190	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C5N99_RS08205	COG0457	Tetratricopeptide repeat
C5N99_RS08210	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C5N99_RS08215	COG3118	belongs to the thioredoxin family
C5N99_RS08220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C5N99_RS08220	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C5N99_RS08255	COG0395	ABC-type sugar transport system, permease component
C5N99_RS08260	COG1175	transmembrane transport
C5N99_RS08265	COG1653	transport
C5N99_RS08290	COG2971	BadF BadG BcrA BcrD
C5N99_RS08300	COG1573	uracil-dna glycosylase
C5N99_RS08305	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C5N99_RS08310	COG1482	cell wall glycoprotein biosynthetic process
C5N99_RS08325	COG1413	lyase activity
C5N99_RS08340	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C5N99_RS08345	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C5N99_RS08355	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C5N99_RS08355	COG0302	gtp cyclohydrolase
C5N99_RS08375	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C5N99_RS08385	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C5N99_RS08395	COG0455	bacterial-type flagellum organization
C5N99_RS08410	COG0848	biopolymer transport protein
C5N99_RS08465	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C5N99_RS08470	COG0187	DNA topoisomerase II activity
C5N99_RS08525	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C5N99_RS08540	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C5N99_RS08545	COG1360	Flagellar Motor Protein
C5N99_RS08550	COG1580	Controls the rotational direction of flagella during chemotaxis
C5N99_RS08555	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C5N99_RS08560	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C5N99_RS08560	COG1776	CheC inhibitor of MCP methylation
C5N99_RS08570	COG1338	Plays a role in the flagellum-specific transport system
C5N99_RS08575	COG1987	bacterial-type flagellum assembly
C5N99_RS08580	COG1684	flagellar biosynthetic protein fliR
C5N99_RS08585	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C5N99_RS08590	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C5N99_RS08595	COG1419	protein localization to endoplasmic reticulum
C5N99_RS08605	COG0534	Mate efflux family protein
C5N99_RS08615	COG0557	exoribonuclease II activity
C5N99_RS08620	COG3177	Filamentation induced by cAMP protein fic
C5N99_RS08625	COG1362	aminopeptidase activity
C5N99_RS08635	COG3608	succinylglutamate desuccinylase aspartoacylase
C5N99_RS08635	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C5N99_RS08640	COG0525	valine-tRNA ligase activity
C5N99_RS08685	COG4974	Belongs to the 'phage' integrase family
C5N99_RS08690	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C5N99_RS08690	COG0551	DNA topoisomerase type I activity
C5N99_RS08695	COG0758	DNA mediated transformation
C5N99_RS08705	COG0475	glutathione-regulated potassium exporter activity
C5N99_RS08710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C5N99_RS08715	COG3579	cysteine-type endopeptidase activity
C5N99_RS08730	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C5N99_RS08735	COG0166	Belongs to the GPI family
C5N99_RS08740	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C5N99_RS08780	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C5N99_RS08790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C5N99_RS08795	COG0574	Belongs to the PEP-utilizing enzyme family
C5N99_RS08795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5N99_RS08810	COG2304	oxidoreductase activity
C5N99_RS08820	COG0183	Belongs to the thiolase family
C5N99_RS08830	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5N99_RS08830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5N99_RS08840	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C5N99_RS08845	COG1773	rubredoxin
C5N99_RS08855	COG0495	leucyl-tRNA aminoacylation
C5N99_RS08900	COG0335	large ribosomal subunit rRNA binding
C5N99_RS08905	COG0336	Belongs to the RNA methyltransferase TrmD family
C5N99_RS08910	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C5N99_RS08915	COG1837	Belongs to the UPF0109 family
C5N99_RS08920	COG0228	four-way junction DNA binding
C5N99_RS08950	COG0395	ABC-type sugar transport system, permease component
C5N99_RS08955	COG4209	transmembrane transport
C5N99_RS08980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C5N99_RS09030	COG0785	Cytochrome C biogenesis protein
C5N99_RS09035	COG0583	DNA-binding transcription factor activity
C5N99_RS09060	COG2337	Toxic component of a toxin-antitoxin (TA) module
C5N99_RS09070	COG2885	chlorophyll binding
C5N99_RS09075	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C5N99_RS09085	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C5N99_RS09115	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C5N99_RS09130	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C5N99_RS09150	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C5N99_RS09165	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C5N99_RS09170	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C5N99_RS09175	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C5N99_RS09190	COG1522	sequence-specific DNA binding
C5N99_RS09195	COG0436	Aminotransferase
C5N99_RS09200	COG0561	phosphatase activity
C5N99_RS09210	COG4608	Belongs to the ABC transporter superfamily
C5N99_RS09215	COG0601	transmembrane transport
C5N99_RS09220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5N99_RS09250	COG1876	peptidase activity
C5N99_RS09255	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5N99_RS09265	COG1268	BioY protein
C5N99_RS09270	COG1122	ATPase activity
C5N99_RS09285	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C5N99_RS09295	COG0552	protein localization to endoplasmic reticulum
C5N99_RS09305	COG4591	ABC-type transport system involved in lipoprotein release permease component
C5N99_RS09310	COG1136	(ABC) transporter
C5N99_RS09320	COG0142	geranyltranstransferase activity
C5N99_RS09325	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C5N99_RS09330	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C5N99_RS09530	COG1078	dGTPase activity
C5N99_RS09585	COG0724	RNA recognition motif
C5N99_RS09590	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5N99_RS09600	COG1196	nuclear chromosome segregation
C5N99_RS09605	COG0504	CTP synthase activity
C5N99_RS09630	COG0482	sulfurtransferase activity
C5N99_RS09640	COG0457	Tetratricopeptide repeat
C5N99_RS09645	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C5N99_RS09650	COG0733	neurotransmitter:sodium symporter activity
C5N99_RS09655	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C5N99_RS09655	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C5N99_RS09655	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C5N99_RS09685	COG1293	RNA-binding protein homologous to eukaryotic snRNP
C5N99_RS09735	COG0534	Mate efflux family protein
C5N99_RS09740	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C5N99_RS09755	COG0357	Ribosomal RNA small subunit methyltransferase G
C5N99_RS09765	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C5N99_RS09770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C5N99_RS09785	COG0708	Exodeoxyribonuclease III
C5N99_RS09805	COG1747	RNA polymerase binding
C5N99_RS09805	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C5N99_RS09815	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C5N99_RS09820	COG3956	TIGRFAM MazG family protein
C5N99_RS09830	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C5N99_RS09835	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C5N99_RS09845	COG0736	holo-[acyl-carrier-protein] synthase activity
C5N99_RS09855	COG0101	tRNA pseudouridine synthase activity
C5N99_RS09865	COG1704	LemA family
C5N99_RS09875	COG1132	(ABC) transporter
C5N99_RS09895	COG1132	(ABC) transporter
C5N99_RS09900	COG1132	(ABC) transporter
C5N99_RS09905	COG2186	Transcriptional regulator
C5N99_RS09910	COG1802	Transcriptional regulator
C5N99_RS09915	COG0632	four-way junction helicase activity
C5N99_RS09920	COG1739	Uncharacterized protein family UPF0029
C5N99_RS09925	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C5N99_RS09930	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C5N99_RS09940	COG0470	DNA polymerase III
C5N99_RS09950	COG2604	Protein of unknown function DUF115
C5N99_RS09955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5N99_RS09960	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C5N99_RS09975	COG2161	toxin-antitoxin pair type II binding
C5N99_RS09980	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5N99_RS10000	COG2211	Major facilitator Superfamily
C5N99_RS10010	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C5N99_RS10015	COG0154	amidase activity
C5N99_RS10020	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C5N99_RS10030	COG4254	PFAM FecR protein
C5N99_RS10040	COG1234	tRNA 3'-trailer cleavage
C5N99_RS10055	COG1454	alcohol dehydrogenase
C5N99_RS10080	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C5N99_RS10085	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C5N99_RS10090	COG0427	acetyl-CoA hydrolase
C5N99_RS10130	COG0497	DNA recombination
C5N99_RS10135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C5N99_RS10140	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C5N99_RS10145	COG0835	chemotaxis
C5N99_RS10155	COG5341	Protein conserved in bacteria
C5N99_RS10160	COG0442	prolyl-tRNA aminoacylation
C5N99_RS10170	COG0424	maF-like protein
C5N99_RS10175	COG0052	Belongs to the universal ribosomal protein uS2 family
C5N99_RS10180	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C5N99_RS10185	COG0233	cytoplasmic translational termination
C5N99_RS10190	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C5N99_RS10195	COG0575	Belongs to the CDS family
C5N99_RS10200	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C5N99_RS10205	COG0750	zinc metalloprotease
C5N99_RS10220	COG1309	transcriptional regulator
C5N99_RS10230	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C5N99_RS10265	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C5N99_RS10270	COG0714	Associated with various cellular activities
C5N99_RS10295	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C5N99_RS10300	COG2890	protein-(glutamine-N5) methyltransferase activity
C5N99_RS10305	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C5N99_RS10310	COG0666	response to abiotic stimulus
C5N99_RS10320	COG3330	Domain of unknown function (DUF4912)
C5N99_RS10325	COG1543	Belongs to the glycosyl hydrolase 57 family
C5N99_RS10330	COG0588	phosphoglycerate mutase activity
C5N99_RS10335	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C5N99_RS10345	COG1131	(ABC) transporter
C5N99_RS10360	COG4886	Leucine-rich repeat (LRR) protein
C5N99_RS10370	COG1131	(ABC) transporter
C5N99_RS10400	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C5N99_RS10405	COG1104	cysteine desulfurase activity
C5N99_RS10410	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C5N99_RS10420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C5N99_RS10425	COG2208	phosphoserine phosphatase activity
C5N99_RS10455	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C5N99_RS10460	COG1321	iron dependent repressor
C5N99_RS10465	COG0803	Belongs to the bacterial solute-binding protein 9 family
C5N99_RS10470	COG1121	(ABC) transporter
C5N99_RS10475	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5N99_RS10480	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5N99_RS10485	COG1683	Conserved Protein
C5N99_RS10495	COG3869	Catalyzes the specific phosphorylation of arginine residues in
C5N99_RS10505	COG3290	protein histidine kinase activity
C5N99_RS10505	COG3829	transcription factor binding
C5N99_RS10515	COG3852	Histidine kinase
C5N99_RS10520	COG2204	response regulator
C5N99_RS10525	COG0823	Involved in the tonB-independent uptake of proteins
C5N99_RS10545	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C5N99_RS10575	COG0149	triose-phosphate isomerase activity
C5N99_RS10580	COG1760	l-serine dehydratase
C5N99_RS10585	COG1760	l-serine dehydratase
C5N99_RS10610	COG0360	Binds together with S18 to 16S ribosomal RNA
C5N99_RS10615	COG0629	single-stranded DNA binding
C5N99_RS10620	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C5N99_RS10625	COG0359	binds to the 23S rRNA
C5N99_RS10630	COG0305	Participates in initiation and elongation during chromosome replication
C5N99_RS10665	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C5N99_RS10680	COG1070	Carbohydrate kinase
C5N99_RS10700	COG2388	GCN5-related N-acetyl-transferase
C5N99_RS10710	COG1309	transcriptional regulator
C5N99_RS10715	COG1620	l-lactate permease
C5N99_RS10720	COG4166	transmembrane transport
C5N99_RS10730	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C5N99_RS10740	COG0569	domain protein
C5N99_RS10745	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C5N99_RS10755	COG1067	ATP-dependent peptidase activity
C5N99_RS10785	COG3142	Participates in the control of copper homeostasis
C5N99_RS10815	COG1388	LysM domain
C5N99_RS10815	COG0741	lytic transglycosylase activity
C5N99_RS10830	COG3876	Protein conserved in bacteria
C5N99_RS10835	COG1472	Belongs to the glycosyl hydrolase 3 family
C5N99_RS10860	COG2226	methyltransferase
C5N99_RS10875	COG0534	Mate efflux family protein
C5N99_RS10880	COG0523	cobalamin synthesis protein
C5N99_RS10890	COG3681	Belongs to the UPF0597 family
C5N99_RS10895	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C5N99_RS10900	COG1129	ABC transporter
C5N99_RS10930	COG1222	aaa ATPase
C5N99_RS10970	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C5N99_RS10990	COG1136	(ABC) transporter
C5N99_RS10995	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C5N99_RS11000	COG0193	aminoacyl-tRNA hydrolase activity
C5N99_RS11020	COG2832	Protein of unknown function (DUF454)
C5N99_RS11025	COG1137	ATPase activity
C5N99_RS11040	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C5N99_RS11040	COG0493	'glutamate synthase
C5N99_RS11045	COG0402	S-adenosylhomocysteine deaminase activity
C5N99_RS11060	COG1120	ATPase activity
C5N99_RS11065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5N99_RS11095	COG1509	lysine 2,3-aminomutase activity
C5N99_RS11100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C5N99_RS11115	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C5N99_RS11125	COG1136	(ABC) transporter
C5N99_RS11130	COG1136	(ABC) transporter
C5N99_RS11130	COG0577	efflux transmembrane transporter activity
C5N99_RS11180	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C5N99_RS11210	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C5N99_RS11215	COG1272	protein, Hemolysin III
C5N99_RS11220	COG0254	rRNA binding
C5N99_RS11225	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C5N99_RS11230	COG1058	Belongs to the CinA family
C5N99_RS11230	COG1546	Belongs to the CinA family
C5N99_RS11240	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C5N99_RS11245	COG0776	regulation of translation
C5N99_RS11250	COG0268	Binds directly to 16S ribosomal RNA
C5N99_RS11270	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5N99_RS11280	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C5N99_RS11290	COG0731	radical SAM domain protein
C5N99_RS11305	COG2201	protein-glutamate methylesterase activity
C5N99_RS11315	COG0835	chemotaxis
C5N99_RS11335	COG3118	belongs to the thioredoxin family
C5N99_RS11360	COG3833	ABC-type maltose transport systems, permease component
C5N99_RS11365	COG1175	transmembrane transport
C5N99_RS11375	COG2182	Extracellular solute-binding protein
C5N99_RS11385	COG0617	tRNA 3'-terminal CCA addition
C5N99_RS11390	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C5N99_RS11415	COG1301	dicarboxylic acid transport
C5N99_RS11425	COG1131	(ABC) transporter
C5N99_RS11440	COG4977	sequence-specific DNA binding
C5N99_RS11465	COG0601	transmembrane transport
C5N99_RS11470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5N99_RS11475	COG0444	Belongs to the ABC transporter superfamily
C5N99_RS11485	COG0747	negative chemotaxis
C5N99_RS11490	COG1418	mRNA catabolic process
C5N99_RS11560	COG1132	(ABC) transporter
C5N99_RS11560	COG2375	cellular response to nickel ion
C5N99_RS11570	COG1132	(ABC) transporter
C5N99_RS11575	COG2357	RelA SpoT domain protein
C5N99_RS11590	COG1131	(ABC) transporter
C5N99_RS11595	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C5N99_RS11600	COG0563	adenylate kinase activity
C5N99_RS11610	COG0772	Belongs to the SEDS family
C5N99_RS11615	COG0768	penicillin binding
C5N99_RS11630	COG1077	Cell shape determining protein MreB Mrl
C5N99_RS11650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C5N99_RS11655	COG0358	DNA primase activity
C5N99_RS11660	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C5N99_RS11680	COG3189	MarR family transcriptional regulator
C5N99_RS11690	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C5N99_RS11695	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C5N99_RS11700	COG1136	(ABC) transporter
C5N99_RS11700	COG0577	efflux transmembrane transporter activity
C5N99_RS11710	COG0318	PFAM AMP-dependent synthetase and ligase
C5N99_RS11715	COG0791	NLP P60 protein
C5N99_RS11725	COG0523	cobalamin synthesis protein
C5N99_RS11735	COG0297	glycogen (starch) synthase activity
C5N99_RS11740	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C5N99_RS11745	COG1047	Peptidyl-prolyl cis-trans
C5N99_RS11760	COG0251	oxidation-reduction process
C5N99_RS11790	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C5N99_RS11810	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C5N99_RS11815	COG3951	Flagellar rod assembly protein muramidase FlgJ
C5N99_RS11825	COG4786	Flagellar basal body rod
C5N99_RS11835	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C5N99_RS11845	COG2226	methyltransferase
C5N99_RS11850	COG0596	Alpha beta hydrolase
C5N99_RS11870	COG1309	transcriptional regulator
C5N99_RS11890	COG0488	(ABC) transporter
C5N99_RS11905	COG1373	ATPase (AAA superfamily
C5N99_RS11910	COG1136	(ABC) transporter
C5N99_RS11915	COG1136	(ABC) transporter
C5N99_RS11915	COG0577	efflux transmembrane transporter activity
C5N99_RS11930	COG3470	protein probably involved in high-affinity Fe2 transport
C5N99_RS11935	COG0672	)-iron permease
C5N99_RS11940	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C5N99_RS11945	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C5N99_RS11950	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C5N99_RS11955	COG1815	bacterial-type flagellum-dependent cell motility
C5N99_RS11970	COG1766	The M ring may be actively involved in energy transduction
C5N99_RS11980	COG1317	bacterial-type flagellum organization
C5N99_RS11985	COG1157	protein secretion by the type III secretion system
C5N99_RS11995	COG1960	acyl-CoA dehydrogenase activity
C5N99_RS12035	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C5N99_RS12050	COG1598	PFAM Uncharacterised protein family UPF0150
C5N99_RS12055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C5N99_RS12090	COG3842	ATPase activity
C5N99_RS12095	COG4988	ABC transporter
C5N99_RS12100	COG1132	(ABC) transporter
C5N99_RS12115	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C5N99_RS12135	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C5N99_RS12140	COG0205	6-phosphofructokinase activity
C5N99_RS12145	COG0285	dihydrofolate synthase activity
C5N99_RS12155	COG0564	pseudouridine synthase activity
C5N99_RS12195	COG0330	HflC and HflK could
C5N99_RS12200	COG0330	HflC and HflK could
C5N99_RS12215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5N99_RS12265	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C5N99_RS12275	COG3800	Transcriptional regulator
C5N99_RS12275	COG1396	sequence-specific DNA binding
C5N99_RS12305	COG1309	transcriptional regulator
C5N99_RS12370	COG0564	pseudouridine synthase activity
C5N99_RS12380	COG3735	TraB family
C5N99_RS12385	COG2001	Belongs to the MraZ family
C5N99_RS12390	COG0275	rRNA processing
C5N99_RS12400	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C5N99_RS12405	COG0772	Belongs to the SEDS family
C5N99_RS12410	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C5N99_RS12420	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C5N99_RS12450	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C5N99_RS12460	COG2358	TRAP transporter, solute receptor (TAXI family
C5N99_RS12500	COG0343	queuine tRNA-ribosyltransferase activity
C5N99_RS12515	COG2375	cellular response to nickel ion
C5N99_RS12515	COG1132	(ABC) transporter
C5N99_RS12520	COG1132	(ABC) transporter
C5N99_RS12525	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C5N99_RS12525	COG0116	Belongs to the methyltransferase superfamily
C5N99_RS12530	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C5N99_RS12545	COG3116	cell division
C5N99_RS12545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C5N99_RS12550	COG0084	hydrolase, TatD family'
C5N99_RS12560	COG1464	Belongs to the NlpA lipoprotein family
C5N99_RS12575	COG1477	protein flavinylation
C5N99_RS12585	COG3588	fructose-bisphosphate aldolase
C5N99_RS12595	COG1247	-acetyltransferase
C5N99_RS12605	COG1979	alcohol dehydrogenase
C5N99_RS12610	COG1994	Peptidase M50
C5N99_RS12620	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C5N99_RS12630	COG0732	type I restriction modification DNA specificity domain
C5N99_RS12635	COG0732	type I restriction modification DNA specificity domain
C5N99_RS12640	COG4974	Belongs to the 'phage' integrase family
C5N99_RS12655	COG0732	type I restriction modification DNA specificity domain