locus-tag	class	description
FFV11_RS00015	COG0592	DNA-directed DNA polymerase activity
FFV11_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FFV11_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
FFV11_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FFV11_RS00040	COG1609	Transcriptional regulator
FFV11_RS00055	COG1609	Transcriptional regulator
FFV11_RS00065	COG1067	ATP-dependent peptidase activity
FFV11_RS00075	COG1747	RNA polymerase binding
FFV11_RS00075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FFV11_RS00125	COG0733	neurotransmitter:sodium symporter activity
FFV11_RS00140	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FFV11_RS00150	COG1253	flavin adenine dinucleotide binding
FFV11_RS00155	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FFV11_RS00170	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FFV11_RS00180	COG0803	Belongs to the bacterial solute-binding protein 9 family
FFV11_RS00185	COG1121	(ABC) transporter
FFV11_RS00190	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FFV11_RS00195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FFV11_RS00215	COG1652	LysM domain
FFV11_RS00240	COG1774	PSP1 C-terminal conserved region
FFV11_RS00255	COG0739	heme binding
FFV11_RS00270	COG2890	protein-(glutamine-N5) methyltransferase activity
FFV11_RS00275	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FFV11_RS00285	COG3630	sodium ion export across plasma membrane
FFV11_RS00295	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
FFV11_RS00300	COG0305	Participates in initiation and elongation during chromosome replication
FFV11_RS00320	COG0629	single-stranded DNA binding
FFV11_RS00365	COG0542	response to heat
FFV11_RS00375	COG1639	'signal transduction protein
FFV11_RS00390	COG1175	transmembrane transport
FFV11_RS00395	COG0395	ABC-type sugar transport system, permease component
FFV11_RS00405	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FFV11_RS00420	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FFV11_RS00425	COG3604	Transcriptional regulator
FFV11_RS00445	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FFV11_RS00445	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FFV11_RS00445	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FFV11_RS00465	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FFV11_RS00470	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FFV11_RS00490	COG0280	phosphate acetyltransferase
FFV11_RS00495	COG0457	Tetratricopeptide repeat
FFV11_RS00505	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FFV11_RS00510	COG0484	heat shock protein binding
FFV11_RS00520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FFV11_RS00525	COG0785	Cytochrome C biogenesis protein
FFV11_RS00540	COG0737	Belongs to the 5'-nucleotidase family
FFV11_RS00545	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FFV11_RS00545	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FFV11_RS00545	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FFV11_RS00555	COG4750	Nucleotidyl transferase
FFV11_RS00560	COG0205	6-phosphofructokinase activity
FFV11_RS00590	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FFV11_RS00595	COG3579	cysteine-type endopeptidase activity
FFV11_RS00600	COG0330	HflC and HflK could
FFV11_RS00605	COG0330	HflC and HflK could
FFV11_RS00610	COG0351	phosphomethylpyrimidine kinase
FFV11_RS00630	COG2011	ABC-type metal ion transport system permease component
FFV11_RS00635	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FFV11_RS00640	COG1509	lysine 2,3-aminomutase activity
FFV11_RS00650	COG0457	Tetratricopeptide repeat
FFV11_RS00655	COG0012	GTP binding
FFV11_RS00660	COG0708	Exodeoxyribonuclease III
FFV11_RS00755	COG0569	domain protein
FFV11_RS00760	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FFV11_RS00765	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FFV11_RS00785	COG1022	Amp-dependent synthetase and ligase
FFV11_RS00805	COG1449	Belongs to the glycosyl hydrolase 57 family
FFV11_RS00840	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
FFV11_RS00880	COG2255	four-way junction helicase activity
FFV11_RS00885	COG0803	Belongs to the bacterial solute-binding protein 9 family
FFV11_RS00895	COG1121	(ABC) transporter
FFV11_RS00900	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FFV11_RS00905	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FFV11_RS00925	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FFV11_RS00930	COG4939	FMN-binding domain protein
FFV11_RS00935	COG2199	diguanylate cyclase activity
FFV11_RS00960	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FFV11_RS00985	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FFV11_RS00990	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FFV11_RS01120	COG0202	RNA polymerase activity
FFV11_RS01135	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FFV11_RS01145	COG0484	heat shock protein binding
FFV11_RS01160	COG1366	Belongs to the anti-sigma-factor antagonist family
FFV11_RS01210	COG1122	ATPase activity
FFV11_RS01215	COG1268	BioY protein
FFV11_RS01220	COG1573	uracil-dna glycosylase
FFV11_RS01225	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FFV11_RS01230	COG0564	pseudouridine synthase activity
FFV11_RS01255	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FFV11_RS01260	COG0250	Participates in transcription elongation, termination and antitermination
FFV11_RS01285	COG0085	RNA polymerase activity
FFV11_RS01305	COG0714	Associated with various cellular activities
FFV11_RS01310	COG2304	oxidoreductase activity
FFV11_RS01315	COG0860	N-Acetylmuramoyl-L-alanine amidase
FFV11_RS01335	COG0776	regulation of translation
FFV11_RS01340	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FFV11_RS01350	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FFV11_RS01360	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FFV11_RS01365	COG0584	glycerophosphoryl diester phosphodiesterase
FFV11_RS01390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FFV11_RS01410	COG1114	Component of the transport system for branched-chain amino acids
FFV11_RS01445	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FFV11_RS01450	COG0617	tRNA 3'-terminal CCA addition
FFV11_RS01455	COG1475	DNA binding
FFV11_RS01460	COG1192	Involved in chromosome partitioning
FFV11_RS01485	COG0793	Belongs to the peptidase S41A family
FFV11_RS01495	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
FFV11_RS01505	COG0731	radical SAM domain protein
FFV11_RS01515	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
FFV11_RS01520	COG0561	phosphatase activity
FFV11_RS01530	COG2885	chlorophyll binding
FFV11_RS01535	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FFV11_RS01545	COG0237	dephospho-CoA kinase activity
FFV11_RS01555	COG1744	ABC transporter substrate-binding protein PnrA-like
FFV11_RS01560	COG3845	ABC transporter
FFV11_RS01565	COG4603	Belongs to the binding-protein-dependent transport system permease family
FFV11_RS01570	COG1079	Belongs to the binding-protein-dependent transport system permease family
FFV11_RS01575	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FFV11_RS01580	COG0823	Involved in the tonB-independent uptake of proteins
FFV11_RS01640	COG1744	ABC transporter substrate-binding protein PnrA-like
FFV11_RS01645	COG3845	ABC transporter
FFV11_RS01650	COG4603	Belongs to the binding-protein-dependent transport system permease family
FFV11_RS01655	COG1079	Belongs to the binding-protein-dependent transport system permease family
FFV11_RS01660	COG2911	Protein conserved in bacteria
FFV11_RS01665	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FFV11_RS01680	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FFV11_RS01700	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FFV11_RS01740	COG0285	dihydrofolate synthase activity
FFV11_RS01750	COG1102	Psort location Cytoplasmic, score
FFV11_RS01790	COG1047	Peptidyl-prolyl cis-trans
FFV11_RS01810	COG4443	Transcriptional Coactivator p15 (PC4)
FFV11_RS01825	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FFV11_RS01845	COG1543	Belongs to the glycosyl hydrolase 57 family
FFV11_RS01850	COG3330	Domain of unknown function (DUF4912)
FFV11_RS01875	COG2198	Histidine kinase
FFV11_RS01875	COG0643	Histidine kinase
FFV11_RS01880	COG0835	chemotaxis
FFV11_RS01890	COG2201	protein-glutamate methylesterase activity
FFV11_RS01900	COG1196	nuclear chromosome segregation
FFV11_RS01910	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FFV11_RS01940	COG0457	Tetratricopeptide repeat
FFV11_RS01965	COG0653	protein targeting
FFV11_RS01975	COG5522	Integral membrane protein (intg_mem_TP0381)
FFV11_RS01995	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FFV11_RS02005	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FFV11_RS02015	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FFV11_RS02020	COG4974	Belongs to the 'phage' integrase family
FFV11_RS02030	COG0758	DNA mediated transformation
FFV11_RS02035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FFV11_RS02035	COG0551	DNA topoisomerase type I activity
FFV11_RS02040	COG4974	Belongs to the 'phage' integrase family
FFV11_RS02045	COG1815	bacterial-type flagellum-dependent cell motility
FFV11_RS02060	COG1766	The M ring may be actively involved in energy transduction
FFV11_RS02070	COG1317	bacterial-type flagellum organization
FFV11_RS02075	COG1157	protein secretion by the type III secretion system
FFV11_RS02085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FFV11_RS02110	COG1862	Preprotein translocase
FFV11_RS02115	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FFV11_RS02120	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FFV11_RS02135	COG1115	amino acid carrier protein
FFV11_RS02145	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FFV11_RS02150	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FFV11_RS02155	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FFV11_RS02160	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FFV11_RS02190	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
FFV11_RS02195	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
FFV11_RS02200	COG1394	ATPase activity, coupled to movement of substances
FFV11_RS02205	COG1269	ATP hydrolysis coupled proton transport
FFV11_RS02230	COG3015	lipoprotein NlpE involved in copper resistance
FFV11_RS02235	COG1227	inorganic diphosphatase activity
FFV11_RS02250	COG0835	chemotaxis
FFV11_RS02265	COG0497	DNA recombination
FFV11_RS02285	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FFV11_RS02290	COG3118	belongs to the thioredoxin family
FFV11_RS02295	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FFV11_RS02300	COG0457	Tetratricopeptide repeat
FFV11_RS02305	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FFV11_RS02315	COG2252	PERMEase
FFV11_RS02335	COG3706	GGDEF domain
FFV11_RS02355	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FFV11_RS02440	COG0363	glucosamine-6-phosphate deaminase activity
FFV11_RS02445	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FFV11_RS02455	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
FFV11_RS02460	COG2982	Protein involved in outer membrane biogenesis
FFV11_RS02470	COG4254	PFAM FecR protein
FFV11_RS02490	COG0840	transmembrane signaling receptor activity
FFV11_RS02515	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FFV11_RS02520	COG0358	DNA primase activity
FFV11_RS02525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FFV11_RS02545	COG1077	Cell shape determining protein MreB Mrl
FFV11_RS02560	COG0768	penicillin binding
FFV11_RS02565	COG0772	Belongs to the SEDS family
FFV11_RS02570	COG0666	response to abiotic stimulus
FFV11_RS02610	COG0740	serine-type endopeptidase activity
FFV11_RS02620	COG0450	alkyl hydroperoxide reductase
FFV11_RS02630	COG1329	Transcriptional regulator
FFV11_RS02635	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FFV11_RS02635	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FFV11_RS02645	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FFV11_RS02655	COG0728	peptidoglycan biosynthetic process
FFV11_RS02670	COG2204	response regulator
FFV11_RS02680	COG0470	DNA polymerase III
FFV11_RS02685	COG1286	toxin biosynthetic process
FFV11_RS02695	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FFV11_RS02715	COG1394	ATPase activity, coupled to movement of substances
FFV11_RS02720	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
FFV11_RS02725	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
FFV11_RS02745	COG1269	ATP hydrolysis coupled proton transport
FFV11_RS02750	COG1527	subunit (C
FFV11_RS02760	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FFV11_RS02790	COG1366	Belongs to the anti-sigma-factor antagonist family
FFV11_RS02805	COG0205	6-phosphofructokinase activity
FFV11_RS02825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FFV11_RS02870	COG0628	permease
FFV11_RS02875	COG0546	phosphoglycolate phosphatase activity
FFV11_RS02905	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FFV11_RS02910	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
FFV11_RS02915	COG2089	acid synthase
FFV11_RS02945	COG0800	Aldolase
FFV11_RS02950	COG0006	proline dipeptidase activity
FFV11_RS02965	COG3976	FMN-binding domain protein
FFV11_RS02965	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
FFV11_RS02975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FFV11_RS02990	COG0552	protein localization to endoplasmic reticulum
FFV11_RS03000	COG4591	ABC-type transport system involved in lipoprotein release permease component
FFV11_RS03005	COG1136	(ABC) transporter
FFV11_RS03020	COG4166	transmembrane transport
FFV11_RS03030	COG1466	dna polymerase III delta subunit
FFV11_RS03035	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FFV11_RS03070	COG3064	Membrane
FFV11_RS03085	COG0617	tRNA 3'-terminal CCA addition
FFV11_RS03100	COG0750	zinc metalloprotease
FFV11_RS03105	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FFV11_RS03110	COG0575	Belongs to the CDS family
FFV11_RS03115	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FFV11_RS03140	COG1413	lyase activity
FFV11_RS03160	COG0719	Fe-S assembly protein
FFV11_RS03165	COG0719	Fe-S assembly protein
FFV11_RS03170	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FFV11_RS03215	COG0741	lytic transglycosylase activity
FFV11_RS03215	COG1388	LysM domain
FFV11_RS03230	COG0420	3'-5' exonuclease activity
FFV11_RS03235	COG0419	ATPase involved in DNA repair
FFV11_RS03240	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FFV11_RS03255	COG2201	protein-glutamate methylesterase activity
FFV11_RS03260	COG0180	Tryptophanyl-tRNA synthetase
FFV11_RS03265	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FFV11_RS03265	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FFV11_RS03310	COG3290	protein histidine kinase activity
FFV11_RS03310	COG0840	transmembrane signaling receptor activity
FFV11_RS03315	COG0840	transmembrane signaling receptor activity
FFV11_RS03330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FFV11_RS03335	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FFV11_RS03340	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
FFV11_RS03370	COG1480	7TM receptor with intracellular HD hydrolase
FFV11_RS03375	COG3842	ATPase activity
FFV11_RS03385	COG1177	transmembrane transport
FFV11_RS03420	COG0191	fructose-bisphosphate aldolase activity
FFV11_RS03445	COG0572	uridine kinase
FFV11_RS03460	COG0587	DNA-directed DNA polymerase activity
FFV11_RS03490	COG2840	Smr protein MutS2
FFV11_RS03495	COG3735	TraB family
FFV11_RS03515	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FFV11_RS03540	COG0142	geranyltranstransferase activity
FFV11_RS03550	COG1879	ABC-type sugar transport system periplasmic component
FFV11_RS03555	COG1129	ABC transporter
FFV11_RS03560	COG4211	Belongs to the binding-protein-dependent transport system permease family
FFV11_RS03565	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FFV11_RS03570	COG1619	proteins homologs of microcin C7 resistance protein MccF
FFV11_RS03585	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FFV11_RS03610	COG0151	Belongs to the GarS family
FFV11_RS03645	COG0739	heme binding
FFV11_RS03650	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FFV11_RS03650	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FFV11_RS03660	COG1196	nuclear chromosome segregation
FFV11_RS03660	COG0739	heme binding
FFV11_RS03660	COG0741	lytic transglycosylase activity
FFV11_RS03675	COG1191	sigma factor activity
FFV11_RS03695	COG1419	protein localization to endoplasmic reticulum
FFV11_RS03700	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FFV11_RS03705	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FFV11_RS03710	COG1684	flagellar biosynthetic protein fliR
FFV11_RS03715	COG1987	bacterial-type flagellum assembly
FFV11_RS03720	COG1338	Plays a role in the flagellum-specific transport system
FFV11_RS03730	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FFV11_RS03730	COG1776	CheC inhibitor of MCP methylation
FFV11_RS03735	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FFV11_RS03740	COG1580	Controls the rotational direction of flagella during chemotaxis
FFV11_RS03745	COG1360	Flagellar Motor Protein
FFV11_RS03750	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FFV11_RS03760	COG1749	Flagellar hook protein flgE
FFV11_RS03765	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FFV11_RS03795	COG0813	purine-nucleoside phosphorylase activity
FFV11_RS03800	COG0493	'glutamate synthase
FFV11_RS03805	COG0543	2 iron, 2 sulfur cluster binding
FFV11_RS03815	COG0799	negative regulation of ribosome biogenesis
FFV11_RS03855	COG0574	Belongs to the PEP-utilizing enzyme family
FFV11_RS03855	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FFV11_RS03875	COG2304	oxidoreductase activity
FFV11_RS03920	COG0768	penicillin binding
FFV11_RS03925	COG2604	Protein of unknown function DUF115
FFV11_RS03930	COG2604	Protein of unknown function DUF115
FFV11_RS03945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FFV11_RS03960	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FFV11_RS03975	COG1652	LysM domain
FFV11_RS03995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FFV11_RS04010	COG1285	pathogenesis
FFV11_RS04015	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FFV11_RS04035	COG3956	TIGRFAM MazG family protein
FFV11_RS04045	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FFV11_RS04045	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FFV11_RS04050	COG0739	heme binding
FFV11_RS04070	COG1137	ATPase activity
FFV11_RS04085	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FFV11_RS04100	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FFV11_RS04115	COG1477	protein flavinylation
FFV11_RS04120	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FFV11_RS04125	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FFV11_RS04125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FFV11_RS04130	COG1686	Belongs to the peptidase S11 family
FFV11_RS04135	COG0542	response to heat
FFV11_RS04150	COG3842	ATPase activity
FFV11_RS04155	COG0557	exoribonuclease II activity
FFV11_RS04180	COG0338	D12 class N6 adenine-specific DNA methyltransferase
FFV11_RS04200	COG0492	ferredoxin-NADP+ reductase activity
FFV11_RS04230	COG1464	Belongs to the NlpA lipoprotein family
FFV11_RS04235	COG0668	transmembrane transport
FFV11_RS04240	COG2033	superoxide reductase activity
FFV11_RS04295	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FFV11_RS04315	COG0488	(ABC) transporter
FFV11_RS04330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FFV11_RS04340	COG0024	Methionine aminopeptidase
FFV11_RS04345	COG0484	heat shock protein binding
FFV11_RS04350	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FFV11_RS04355	COG1671	Belongs to the UPF0178 family
FFV11_RS04360	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
FFV11_RS04385	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FFV11_RS04390	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FFV11_RS04395	COG0455	bacterial-type flagellum organization
FFV11_RS04425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FFV11_RS04430	COG0545	Peptidyl-prolyl cis-trans isomerase
FFV11_RS04435	COG1104	cysteine desulfurase activity
FFV11_RS04440	COG3942	CHAP domain
FFV11_RS04440	COG1388	LysM domain
FFV11_RS04475	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FFV11_RS04480	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FFV11_RS04480	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FFV11_RS04495	COG0802	atpase or kinase
FFV11_RS04500	COG1214	PFAM Peptidase M22, glycoprotease
FFV11_RS04505	COG2770	Histidine kinase
FFV11_RS04505	COG3437	response regulator, receiver
FFV11_RS04525	COG4555	ABC transporter
FFV11_RS04575	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FFV11_RS04585	COG0779	Required for maturation of 30S ribosomal subunits
FFV11_RS04610	COG2887	Belongs to the helicase family. UvrD subfamily
FFV11_RS04625	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FFV11_RS04640	COG1837	Belongs to the UPF0109 family
FFV11_RS04645	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FFV11_RS04650	COG0336	Belongs to the RNA methyltransferase TrmD family
FFV11_RS04665	COG2257	FlhB HrpN YscU SpaS Family
FFV11_RS04695	COG2239	Acts as a magnesium transporter
FFV11_RS04705	COG3118	belongs to the thioredoxin family
FFV11_RS04710	COG0457	Tetratricopeptide repeat
FFV11_RS04745	COG0716	FMN binding
FFV11_RS04750	COG0681	Belongs to the peptidase S26 family
FFV11_RS04760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FFV11_RS04765	COG2604	Protein of unknown function DUF115
FFV11_RS04775	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FFV11_RS04800	COG1253	flavin adenine dinucleotide binding
FFV11_RS04815	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FFV11_RS04815	COG1013	pyruvate-flavodoxin oxidoreductase activity
FFV11_RS04815	COG0674	pyruvate-flavodoxin oxidoreductase activity
FFV11_RS04815	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FFV11_RS04840	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FFV11_RS04850	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FFV11_RS04855	COG1847	R3H domain protein
FFV11_RS04860	COG0706	membrane insertase activity
FFV11_RS04865	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FFV11_RS04870	COG0594	ribonuclease P activity
FFV11_RS04910	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FFV11_RS04910	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FFV11_RS04915	COG3951	Flagellar rod assembly protein muramidase FlgJ
FFV11_RS04935	COG1136	(ABC) transporter
FFV11_RS04935	COG0577	efflux transmembrane transporter activity
FFV11_RS04940	COG1136	(ABC) transporter
FFV11_RS04945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FFV11_RS04970	COG3470	protein probably involved in high-affinity Fe2 transport
FFV11_RS04975	COG0672	)-iron permease
FFV11_RS04990	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FFV11_RS05000	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FFV11_RS05005	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FFV11_RS05010	COG0084	hydrolase, TatD family'
FFV11_RS05015	COG3116	cell division
FFV11_RS05015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FFV11_RS05040	COG0326	Molecular chaperone. Has ATPase activity
FFV11_RS05065	COG2095	MarC family integral membrane protein
FFV11_RS05080	COG1773	rubredoxin
FFV11_RS05090	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FFV11_RS05100	COG0084	hydrolase, TatD family'
FFV11_RS05120	COG0616	signal peptide processing
FFV11_RS05125	COG1115	amino acid carrier protein
FFV11_RS05130	COG1674	ftsk spoiiie
FFV11_RS05155	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FFV11_RS05160	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FFV11_RS05165	COG0187	DNA topoisomerase II activity
FFV11_RS05170	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
FFV11_RS05175	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FFV11_RS05195	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FFV11_RS05215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FFV11_RS05220	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FFV11_RS05230	COG1418	mRNA catabolic process
FFV11_RS05235	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FFV11_RS05250	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FFV11_RS05280	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
FFV11_RS05290	COG0724	RNA recognition motif
FFV11_RS05300	COG5341	Protein conserved in bacteria
FFV11_RS05305	COG1752	Esterase of the alpha-beta hydrolase superfamily
FFV11_RS05310	COG0530	calcium, potassium:sodium antiporter activity
FFV11_RS05315	COG0525	valine-tRNA ligase activity
FFV11_RS05325	COG1272	protein, Hemolysin III
FFV11_RS05330	COG0783	Belongs to the Dps family
FFV11_RS05340	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FFV11_RS05345	COG0740	serine-type endopeptidase activity