locus-tag	class	description
TP_RS00010	COG0592	DNA-directed DNA polymerase activity
TP_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TP_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
TP_RS00025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TP_RS00035	COG1609	Transcriptional regulator
TP_RS00055	COG1609	Transcriptional regulator
TP_RS00070	COG1067	ATP-dependent peptidase activity
TP_RS00080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TP_RS00080	COG1747	RNA polymerase binding
TP_RS00130	COG0733	neurotransmitter:sodium symporter activity
TP_RS00145	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TP_RS00155	COG1253	flavin adenine dinucleotide binding
TP_RS00160	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TP_RS00175	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TP_RS00185	COG0803	Belongs to the bacterial solute-binding protein 9 family
TP_RS00190	COG1121	(ABC) transporter
TP_RS00195	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TP_RS00200	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TP_RS00220	COG1652	LysM domain
TP_RS00240	COG1774	PSP1 C-terminal conserved region
TP_RS00255	COG0739	heme binding
TP_RS00265	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TP_RS00270	COG2890	protein-(glutamine-N5) methyltransferase activity
TP_RS00275	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TP_RS00285	COG3630	sodium ion export across plasma membrane
TP_RS00295	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TP_RS00300	COG0305	Participates in initiation and elongation during chromosome replication
TP_RS00315	COG0629	single-stranded DNA binding
TP_RS00360	COG0542	response to heat
TP_RS00370	COG1639	'signal transduction protein
TP_RS00380	COG1175	transmembrane transport
TP_RS00385	COG0395	ABC-type sugar transport system, permease component
TP_RS00395	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TP_RS00410	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
TP_RS00415	COG3604	Transcriptional regulator
TP_RS00430	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TP_RS00430	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TP_RS00430	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TP_RS00450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TP_RS00455	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TP_RS00475	COG0280	phosphate acetyltransferase
TP_RS00480	COG0457	Tetratricopeptide repeat
TP_RS00490	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TP_RS00495	COG0484	heat shock protein binding
TP_RS00505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TP_RS00510	COG0785	Cytochrome C biogenesis protein
TP_RS00525	COG0737	Belongs to the 5'-nucleotidase family
TP_RS00530	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TP_RS00530	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TP_RS00530	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TP_RS00540	COG4750	Nucleotidyl transferase
TP_RS00545	COG0205	6-phosphofructokinase activity
TP_RS00575	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TP_RS00580	COG3579	cysteine-type endopeptidase activity
TP_RS00585	COG0330	HflC and HflK could
TP_RS00590	COG0330	HflC and HflK could
TP_RS00595	COG0351	phosphomethylpyrimidine kinase
TP_RS00615	COG2011	ABC-type metal ion transport system permease component
TP_RS00620	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TP_RS00625	COG1509	lysine 2,3-aminomutase activity
TP_RS00635	COG0457	Tetratricopeptide repeat
TP_RS00640	COG0012	GTP binding
TP_RS00645	COG0708	Exodeoxyribonuclease III
TP_RS00720	COG0569	domain protein
TP_RS00725	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TP_RS00730	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TP_RS00750	COG1022	Amp-dependent synthetase and ligase
TP_RS00770	COG1449	Belongs to the glycosyl hydrolase 57 family
TP_RS00800	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TP_RS00840	COG2255	four-way junction helicase activity
TP_RS00845	COG0803	Belongs to the bacterial solute-binding protein 9 family
TP_RS00850	COG1121	(ABC) transporter
TP_RS00855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TP_RS00860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TP_RS00880	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TP_RS00885	COG4939	FMN-binding domain protein
TP_RS00895	COG2199	diguanylate cyclase activity
TP_RS00925	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TP_RS00950	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TP_RS00955	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TP_RS01075	COG0202	RNA polymerase activity
TP_RS01090	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TP_RS01115	COG1366	Belongs to the anti-sigma-factor antagonist family
TP_RS01165	COG1122	ATPase activity
TP_RS01170	COG1268	BioY protein
TP_RS01175	COG1573	uracil-dna glycosylase
TP_RS01180	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TP_RS01185	COG0564	pseudouridine synthase activity
TP_RS01210	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TP_RS01215	COG0250	Participates in transcription elongation, termination and antitermination
TP_RS01240	COG0085	RNA polymerase activity
TP_RS01260	COG0714	Associated with various cellular activities
TP_RS01265	COG2304	oxidoreductase activity
TP_RS01270	COG0860	N-Acetylmuramoyl-L-alanine amidase
TP_RS01285	COG0776	regulation of translation
TP_RS01290	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TP_RS01300	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TP_RS01310	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TP_RS01315	COG0584	glycerophosphoryl diester phosphodiesterase
TP_RS01340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TP_RS01355	COG1114	Component of the transport system for branched-chain amino acids
TP_RS01390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TP_RS01395	COG0617	tRNA 3'-terminal CCA addition
TP_RS01400	COG1475	DNA binding
TP_RS01405	COG1192	Involved in chromosome partitioning
TP_RS01430	COG0793	Belongs to the peptidase S41A family
TP_RS01440	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
TP_RS01455	COG0731	radical SAM domain protein
TP_RS01470	COG0561	phosphatase activity
TP_RS01480	COG2885	chlorophyll binding
TP_RS01485	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TP_RS01495	COG0237	dephospho-CoA kinase activity
TP_RS01505	COG1744	ABC transporter substrate-binding protein PnrA-like
TP_RS01510	COG3845	ABC transporter
TP_RS01515	COG3845	ABC transporter
TP_RS01520	COG4603	Belongs to the binding-protein-dependent transport system permease family
TP_RS01525	COG1079	Belongs to the binding-protein-dependent transport system permease family
TP_RS01530	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TP_RS01535	COG0823	Involved in the tonB-independent uptake of proteins
TP_RS01595	COG1744	ABC transporter substrate-binding protein PnrA-like
TP_RS01600	COG3845	ABC transporter
TP_RS01605	COG4603	Belongs to the binding-protein-dependent transport system permease family
TP_RS01610	COG1079	Belongs to the binding-protein-dependent transport system permease family
TP_RS01615	COG2911	Protein conserved in bacteria
TP_RS01625	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TP_RS01665	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TP_RS01705	COG0285	dihydrofolate synthase activity
TP_RS01715	COG1102	Psort location Cytoplasmic, score
TP_RS01750	COG1047	Peptidyl-prolyl cis-trans
TP_RS01765	COG4443	Transcriptional Coactivator p15 (PC4)
TP_RS01775	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TP_RS01790	COG1543	Belongs to the glycosyl hydrolase 57 family
TP_RS01795	COG3330	Domain of unknown function (DUF4912)
TP_RS01815	COG2198	Histidine kinase
TP_RS01815	COG0643	Histidine kinase
TP_RS01820	COG0835	chemotaxis
TP_RS01830	COG2201	protein-glutamate methylesterase activity
TP_RS01840	COG1196	nuclear chromosome segregation
TP_RS01850	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TP_RS01880	COG0457	Tetratricopeptide repeat
TP_RS01900	COG0653	protein targeting
TP_RS01910	COG5522	Integral membrane protein (intg_mem_TP0381)
TP_RS01930	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TP_RS01940	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TP_RS01950	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TP_RS01955	COG4974	Belongs to the 'phage' integrase family
TP_RS01965	COG0758	DNA mediated transformation
TP_RS01970	COG0551	DNA topoisomerase type I activity
TP_RS01970	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TP_RS01975	COG4974	Belongs to the 'phage' integrase family
TP_RS01980	COG1815	bacterial-type flagellum-dependent cell motility
TP_RS01995	COG1766	The M ring may be actively involved in energy transduction
TP_RS02005	COG1317	bacterial-type flagellum organization
TP_RS02010	COG1157	protein secretion by the type III secretion system
TP_RS02020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TP_RS02045	COG1862	Preprotein translocase
TP_RS02050	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TP_RS02055	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TP_RS02070	COG1115	amino acid carrier protein
TP_RS02080	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TP_RS02085	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TP_RS02090	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TP_RS02095	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TP_RS02130	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TP_RS02135	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TP_RS02140	COG1394	ATPase activity, coupled to movement of substances
TP_RS02145	COG1269	ATP hydrolysis coupled proton transport
TP_RS02155	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TP_RS02170	COG3015	lipoprotein NlpE involved in copper resistance
TP_RS02175	COG1227	inorganic diphosphatase activity
TP_RS02190	COG0835	chemotaxis
TP_RS02205	COG0497	DNA recombination
TP_RS02225	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TP_RS02230	COG3118	belongs to the thioredoxin family
TP_RS02235	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TP_RS02240	COG0457	Tetratricopeptide repeat
TP_RS02245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TP_RS02265	COG3706	GGDEF domain
TP_RS02285	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TP_RS02365	COG0363	glucosamine-6-phosphate deaminase activity
TP_RS02370	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TP_RS02380	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
TP_RS02385	COG2982	Protein involved in outer membrane biogenesis
TP_RS02400	COG4254	PFAM FecR protein
TP_RS02415	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TP_RS02420	COG0840	transmembrane signaling receptor activity
TP_RS02445	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TP_RS02450	COG0358	DNA primase activity
TP_RS02455	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TP_RS02470	COG1077	Cell shape determining protein MreB Mrl
TP_RS02485	COG0768	penicillin binding
TP_RS02490	COG0772	Belongs to the SEDS family
TP_RS02495	COG0666	response to abiotic stimulus
TP_RS02530	COG0740	serine-type endopeptidase activity
TP_RS02540	COG0450	alkyl hydroperoxide reductase
TP_RS02550	COG1329	Transcriptional regulator
TP_RS02555	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TP_RS02555	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TP_RS02565	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TP_RS02575	COG0728	peptidoglycan biosynthetic process
TP_RS02590	COG2204	response regulator
TP_RS02600	COG0470	DNA polymerase III
TP_RS02605	COG1286	toxin biosynthetic process
TP_RS02615	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TP_RS02635	COG1394	ATPase activity, coupled to movement of substances
TP_RS02640	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TP_RS02645	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TP_RS02660	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TP_RS02670	COG1269	ATP hydrolysis coupled proton transport
TP_RS02675	COG1527	subunit (C
TP_RS02685	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TP_RS02710	COG1366	Belongs to the anti-sigma-factor antagonist family
TP_RS02720	COG0205	6-phosphofructokinase activity
TP_RS02740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TP_RS02785	COG0628	permease
TP_RS02790	COG0546	phosphoglycolate phosphatase activity
TP_RS02815	COG0301	tRNA thio-modification
TP_RS02820	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TP_RS02825	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
TP_RS02830	COG2089	acid synthase
TP_RS02865	COG0800	Aldolase
TP_RS02870	COG0006	proline dipeptidase activity
TP_RS02885	COG3976	FMN-binding domain protein
TP_RS02885	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
TP_RS02900	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TP_RS02910	COG0552	protein localization to endoplasmic reticulum
TP_RS02920	COG4591	ABC-type transport system involved in lipoprotein release permease component
TP_RS02925	COG1136	(ABC) transporter
TP_RS02940	COG4166	transmembrane transport
TP_RS02950	COG1466	dna polymerase III delta subunit
TP_RS02960	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TP_RS02965	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TP_RS02995	COG3064	Membrane
TP_RS03010	COG0617	tRNA 3'-terminal CCA addition
TP_RS03030	COG0750	zinc metalloprotease
TP_RS03035	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TP_RS03040	COG0575	Belongs to the CDS family
TP_RS03045	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TP_RS03070	COG1413	lyase activity
TP_RS03095	COG0719	Fe-S assembly protein
TP_RS03100	COG0719	Fe-S assembly protein
TP_RS03105	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TP_RS03150	COG0741	lytic transglycosylase activity
TP_RS03150	COG1388	LysM domain
TP_RS03165	COG0420	3'-5' exonuclease activity
TP_RS03170	COG0419	ATPase involved in DNA repair
TP_RS03175	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TP_RS03190	COG2201	protein-glutamate methylesterase activity
TP_RS03195	COG0180	Tryptophanyl-tRNA synthetase
TP_RS03200	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TP_RS03200	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TP_RS03240	COG0840	transmembrane signaling receptor activity
TP_RS03240	COG3290	protein histidine kinase activity
TP_RS03245	COG0840	transmembrane signaling receptor activity
TP_RS03255	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TP_RS03260	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TP_RS03265	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
TP_RS03295	COG1480	7TM receptor with intracellular HD hydrolase
TP_RS03300	COG3842	ATPase activity
TP_RS03310	COG1177	transmembrane transport
TP_RS03345	COG0191	fructose-bisphosphate aldolase activity
TP_RS03370	COG0572	uridine kinase
TP_RS03385	COG0587	DNA-directed DNA polymerase activity
TP_RS03415	COG2840	Smr protein MutS2
TP_RS03420	COG3735	TraB family
TP_RS03440	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TP_RS03465	COG0142	geranyltranstransferase activity
TP_RS03470	COG1879	ABC-type sugar transport system periplasmic component
TP_RS03475	COG1129	ABC transporter
TP_RS03480	COG4211	Belongs to the binding-protein-dependent transport system permease family
TP_RS03485	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TP_RS03490	COG1619	proteins homologs of microcin C7 resistance protein MccF
TP_RS03505	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TP_RS03530	COG0151	Belongs to the GarS family
TP_RS03570	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TP_RS03570	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TP_RS03580	COG1196	nuclear chromosome segregation
TP_RS03580	COG0741	lytic transglycosylase activity
TP_RS03580	COG0739	heme binding
TP_RS03595	COG1191	sigma factor activity
TP_RS03615	COG1419	protein localization to endoplasmic reticulum
TP_RS03620	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TP_RS03625	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TP_RS03630	COG1684	flagellar biosynthetic protein fliR
TP_RS03635	COG1987	bacterial-type flagellum assembly
TP_RS03640	COG1338	Plays a role in the flagellum-specific transport system
TP_RS03650	COG1776	CheC inhibitor of MCP methylation
TP_RS03650	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TP_RS03655	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TP_RS03660	COG1580	Controls the rotational direction of flagella during chemotaxis
TP_RS03665	COG1360	Flagellar Motor Protein
TP_RS03670	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TP_RS03680	COG1749	Flagellar hook protein flgE
TP_RS03685	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TP_RS03715	COG0813	purine-nucleoside phosphorylase activity
TP_RS03720	COG0493	'glutamate synthase
TP_RS03725	COG0543	2 iron, 2 sulfur cluster binding
TP_RS03735	COG0799	negative regulation of ribosome biogenesis
TP_RS03775	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TP_RS03775	COG0574	Belongs to the PEP-utilizing enzyme family
TP_RS03790	COG2304	oxidoreductase activity
TP_RS03835	COG0768	penicillin binding
TP_RS03840	COG2604	Protein of unknown function DUF115
TP_RS03845	COG2604	Protein of unknown function DUF115
TP_RS03860	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TP_RS03870	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TP_RS03880	COG1652	LysM domain
TP_RS03915	COG1285	pathogenesis
TP_RS03920	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TP_RS03935	COG3956	TIGRFAM MazG family protein
TP_RS03945	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TP_RS03945	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TP_RS03950	COG0739	heme binding
TP_RS03975	COG1137	ATPase activity
TP_RS03990	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TP_RS04005	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TP_RS04020	COG1477	protein flavinylation
TP_RS04025	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TP_RS04030	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TP_RS04030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TP_RS04035	COG1686	Belongs to the peptidase S11 family
TP_RS04040	COG0542	response to heat
TP_RS04055	COG0557	exoribonuclease II activity
TP_RS04080	COG0338	D12 class N6 adenine-specific DNA methyltransferase
TP_RS04095	COG0492	ferredoxin-NADP+ reductase activity
TP_RS04125	COG1464	Belongs to the NlpA lipoprotein family
TP_RS04130	COG0668	transmembrane transport
TP_RS04135	COG2033	superoxide reductase activity
TP_RS04190	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TP_RS04210	COG0488	(ABC) transporter
TP_RS04225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TP_RS04230	COG0024	Methionine aminopeptidase
TP_RS04235	COG0484	heat shock protein binding
TP_RS04240	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TP_RS04245	COG1671	Belongs to the UPF0178 family
TP_RS04250	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
TP_RS04275	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TP_RS04280	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TP_RS04285	COG0455	bacterial-type flagellum organization
TP_RS04320	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TP_RS04325	COG0545	Peptidyl-prolyl cis-trans isomerase
TP_RS04330	COG1104	cysteine desulfurase activity
TP_RS04335	COG1388	LysM domain
TP_RS04335	COG3942	CHAP domain
TP_RS04355	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TP_RS04365	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TP_RS04370	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TP_RS04370	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TP_RS04385	COG0802	atpase or kinase
TP_RS04390	COG1214	PFAM Peptidase M22, glycoprotease
TP_RS04395	COG2770	Histidine kinase
TP_RS04395	COG3437	response regulator, receiver
TP_RS04415	COG4555	ABC transporter
TP_RS04465	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TP_RS04475	COG0779	Required for maturation of 30S ribosomal subunits
TP_RS04515	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TP_RS04525	COG1837	Belongs to the UPF0109 family
TP_RS04530	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TP_RS04535	COG0336	Belongs to the RNA methyltransferase TrmD family
TP_RS04550	COG2257	FlhB HrpN YscU SpaS Family
TP_RS04580	COG2239	Acts as a magnesium transporter
TP_RS04590	COG3118	belongs to the thioredoxin family
TP_RS04595	COG0457	Tetratricopeptide repeat
TP_RS04620	COG2183	response to ionizing radiation
TP_RS04630	COG0716	FMN binding
TP_RS04635	COG0681	Belongs to the peptidase S26 family
TP_RS04655	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TP_RS04660	COG2604	Protein of unknown function DUF115
TP_RS04670	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TP_RS04690	COG1253	flavin adenine dinucleotide binding
TP_RS04705	COG0674	pyruvate-flavodoxin oxidoreductase activity
TP_RS04705	COG1013	pyruvate-flavodoxin oxidoreductase activity
TP_RS04705	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TP_RS04705	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TP_RS04730	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TP_RS04740	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TP_RS04745	COG1847	R3H domain protein
TP_RS04750	COG0706	membrane insertase activity
TP_RS04755	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TP_RS04800	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TP_RS04800	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TP_RS04805	COG3951	Flagellar rod assembly protein muramidase FlgJ
TP_RS04825	COG0577	efflux transmembrane transporter activity
TP_RS04825	COG1136	(ABC) transporter
TP_RS04830	COG1136	(ABC) transporter
TP_RS04835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TP_RS04860	COG3470	protein probably involved in high-affinity Fe2 transport
TP_RS04865	COG0672	)-iron permease
TP_RS04880	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TP_RS04890	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TP_RS04895	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TP_RS04900	COG0084	hydrolase, TatD family'
TP_RS04905	COG3116	cell division
TP_RS04905	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TP_RS04925	COG0326	Molecular chaperone. Has ATPase activity
TP_RS04945	COG2095	MarC family integral membrane protein
TP_RS04960	COG1773	rubredoxin
TP_RS04970	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TP_RS04980	COG0084	hydrolase, TatD family'
TP_RS05000	COG0616	signal peptide processing
TP_RS05005	COG1115	amino acid carrier protein
TP_RS05010	COG1674	ftsk spoiiie
TP_RS05035	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TP_RS05040	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TP_RS05045	COG0187	DNA topoisomerase II activity
TP_RS05050	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TP_RS05055	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TP_RS05075	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TP_RS05095	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TP_RS05100	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TP_RS05110	COG1418	mRNA catabolic process
TP_RS05115	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TP_RS05130	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TP_RS05165	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
TP_RS05175	COG0724	RNA recognition motif
TP_RS05190	COG5341	Protein conserved in bacteria
TP_RS05195	COG1752	Esterase of the alpha-beta hydrolase superfamily
TP_RS05200	COG0530	calcium, potassium:sodium antiporter activity
TP_RS05205	COG0525	valine-tRNA ligase activity
TP_RS05215	COG1272	protein, Hemolysin III
TP_RS05220	COG0783	Belongs to the Dps family
TP_RS05230	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
TP_RS05235	COG0740	serine-type endopeptidase activity