locus-tag	class	description
TPSEA814_RS00010	COG0592	DNA-directed DNA polymerase activity
TPSEA814_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TPSEA814_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
TPSEA814_RS00025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TPSEA814_RS00035	COG1609	Transcriptional regulator
TPSEA814_RS00050	COG1609	Transcriptional regulator
TPSEA814_RS00060	COG1067	ATP-dependent peptidase activity
TPSEA814_RS00070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TPSEA814_RS00070	COG1747	RNA polymerase binding
TPSEA814_RS00115	COG0733	neurotransmitter:sodium symporter activity
TPSEA814_RS00130	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TPSEA814_RS00140	COG1253	flavin adenine dinucleotide binding
TPSEA814_RS00145	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TPSEA814_RS00160	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TPSEA814_RS00170	COG0803	Belongs to the bacterial solute-binding protein 9 family
TPSEA814_RS00175	COG1121	(ABC) transporter
TPSEA814_RS00180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TPSEA814_RS00185	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TPSEA814_RS00205	COG1652	LysM domain
TPSEA814_RS00225	COG1774	PSP1 C-terminal conserved region
TPSEA814_RS00255	COG2890	protein-(glutamine-N5) methyltransferase activity
TPSEA814_RS00260	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TPSEA814_RS00270	COG3630	sodium ion export across plasma membrane
TPSEA814_RS00280	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TPSEA814_RS00285	COG0305	Participates in initiation and elongation during chromosome replication
TPSEA814_RS00300	COG0629	single-stranded DNA binding
TPSEA814_RS00345	COG0542	response to heat
TPSEA814_RS00355	COG1639	'signal transduction protein
TPSEA814_RS00365	COG1175	transmembrane transport
TPSEA814_RS00370	COG0395	ABC-type sugar transport system, permease component
TPSEA814_RS00380	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TPSEA814_RS00395	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
TPSEA814_RS00400	COG3604	Transcriptional regulator
TPSEA814_RS00415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TPSEA814_RS00415	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TPSEA814_RS00415	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TPSEA814_RS00435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TPSEA814_RS00440	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TPSEA814_RS00460	COG0280	phosphate acetyltransferase
TPSEA814_RS00465	COG0457	Tetratricopeptide repeat
TPSEA814_RS00475	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TPSEA814_RS00480	COG0484	heat shock protein binding
TPSEA814_RS00490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TPSEA814_RS00495	COG0785	Cytochrome C biogenesis protein
TPSEA814_RS00510	COG0737	Belongs to the 5'-nucleotidase family
TPSEA814_RS00515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TPSEA814_RS00515	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TPSEA814_RS00515	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TPSEA814_RS00525	COG4750	Nucleotidyl transferase
TPSEA814_RS00530	COG0205	6-phosphofructokinase activity
TPSEA814_RS00560	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TPSEA814_RS00570	COG0330	HflC and HflK could
TPSEA814_RS00575	COG0330	HflC and HflK could
TPSEA814_RS00580	COG0351	phosphomethylpyrimidine kinase
TPSEA814_RS00600	COG2011	ABC-type metal ion transport system permease component
TPSEA814_RS00605	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TPSEA814_RS00610	COG1509	lysine 2,3-aminomutase activity
TPSEA814_RS00625	COG0012	GTP binding
TPSEA814_RS00630	COG0708	Exodeoxyribonuclease III
TPSEA814_RS00720	COG0569	domain protein
TPSEA814_RS00725	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TPSEA814_RS00730	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TPSEA814_RS00750	COG1022	Amp-dependent synthetase and ligase
TPSEA814_RS00770	COG1449	Belongs to the glycosyl hydrolase 57 family
TPSEA814_RS00800	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TPSEA814_RS00840	COG2255	four-way junction helicase activity
TPSEA814_RS00845	COG0803	Belongs to the bacterial solute-binding protein 9 family
TPSEA814_RS00850	COG1121	(ABC) transporter
TPSEA814_RS00855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TPSEA814_RS00860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TPSEA814_RS00880	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TPSEA814_RS00885	COG4939	FMN-binding domain protein
TPSEA814_RS00890	COG2199	diguanylate cyclase activity
TPSEA814_RS00915	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TPSEA814_RS00940	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TPSEA814_RS00945	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TPSEA814_RS01070	COG0202	RNA polymerase activity
TPSEA814_RS01085	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TPSEA814_RS01095	COG0484	heat shock protein binding
TPSEA814_RS01110	COG1366	Belongs to the anti-sigma-factor antagonist family
TPSEA814_RS01160	COG1122	ATPase activity
TPSEA814_RS01165	COG1268	BioY protein
TPSEA814_RS01170	COG1573	uracil-dna glycosylase
TPSEA814_RS01175	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TPSEA814_RS01180	COG0564	pseudouridine synthase activity
TPSEA814_RS01205	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TPSEA814_RS01210	COG0250	Participates in transcription elongation, termination and antitermination
TPSEA814_RS01235	COG0085	RNA polymerase activity
TPSEA814_RS01255	COG0714	Associated with various cellular activities
TPSEA814_RS01260	COG2304	oxidoreductase activity
TPSEA814_RS01265	COG0860	N-Acetylmuramoyl-L-alanine amidase
TPSEA814_RS01280	COG0776	regulation of translation
TPSEA814_RS01285	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TPSEA814_RS01295	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TPSEA814_RS01305	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TPSEA814_RS01310	COG0584	glycerophosphoryl diester phosphodiesterase
TPSEA814_RS01335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TPSEA814_RS01350	COG1114	Component of the transport system for branched-chain amino acids
TPSEA814_RS01385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TPSEA814_RS01390	COG0617	tRNA 3'-terminal CCA addition
TPSEA814_RS01395	COG1475	DNA binding
TPSEA814_RS01400	COG1192	Involved in chromosome partitioning
TPSEA814_RS01425	COG0793	Belongs to the peptidase S41A family
TPSEA814_RS01435	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
TPSEA814_RS01445	COG0731	radical SAM domain protein
TPSEA814_RS01455	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
TPSEA814_RS01460	COG0561	phosphatase activity
TPSEA814_RS01470	COG2885	chlorophyll binding
TPSEA814_RS01475	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TPSEA814_RS01485	COG0237	dephospho-CoA kinase activity
TPSEA814_RS01495	COG1744	ABC transporter substrate-binding protein PnrA-like
TPSEA814_RS01500	COG3845	ABC transporter
TPSEA814_RS01505	COG4603	Belongs to the binding-protein-dependent transport system permease family
TPSEA814_RS01510	COG1079	Belongs to the binding-protein-dependent transport system permease family
TPSEA814_RS01515	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TPSEA814_RS01520	COG0823	Involved in the tonB-independent uptake of proteins
TPSEA814_RS01580	COG1744	ABC transporter substrate-binding protein PnrA-like
TPSEA814_RS01585	COG3845	ABC transporter
TPSEA814_RS01590	COG4603	Belongs to the binding-protein-dependent transport system permease family
TPSEA814_RS01595	COG1079	Belongs to the binding-protein-dependent transport system permease family
TPSEA814_RS01600	COG2911	Protein conserved in bacteria
TPSEA814_RS01605	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TPSEA814_RS01640	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TPSEA814_RS01680	COG0285	dihydrofolate synthase activity
TPSEA814_RS01690	COG1102	Psort location Cytoplasmic, score
TPSEA814_RS01725	COG1047	Peptidyl-prolyl cis-trans
TPSEA814_RS01740	COG4443	Transcriptional Coactivator p15 (PC4)
TPSEA814_RS01750	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TPSEA814_RS01765	COG1543	Belongs to the glycosyl hydrolase 57 family
TPSEA814_RS01770	COG3330	Domain of unknown function (DUF4912)
TPSEA814_RS01785	COG2198	Histidine kinase
TPSEA814_RS01785	COG0643	Histidine kinase
TPSEA814_RS01790	COG0835	chemotaxis
TPSEA814_RS01800	COG2201	protein-glutamate methylesterase activity
TPSEA814_RS01810	COG1196	nuclear chromosome segregation
TPSEA814_RS01850	COG0457	Tetratricopeptide repeat
TPSEA814_RS01870	COG0653	protein targeting
TPSEA814_RS01880	COG5522	Integral membrane protein (intg_mem_TP0381)
TPSEA814_RS01900	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TPSEA814_RS01910	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TPSEA814_RS01920	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TPSEA814_RS01925	COG4974	Belongs to the 'phage' integrase family
TPSEA814_RS01935	COG0758	DNA mediated transformation
TPSEA814_RS01940	COG0551	DNA topoisomerase type I activity
TPSEA814_RS01940	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TPSEA814_RS01950	COG1815	bacterial-type flagellum-dependent cell motility
TPSEA814_RS01975	COG1317	bacterial-type flagellum organization
TPSEA814_RS01980	COG1157	protein secretion by the type III secretion system
TPSEA814_RS01990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TPSEA814_RS02015	COG1862	Preprotein translocase
TPSEA814_RS02020	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TPSEA814_RS02025	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TPSEA814_RS02040	COG1115	amino acid carrier protein
TPSEA814_RS02050	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TPSEA814_RS02055	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TPSEA814_RS02060	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TPSEA814_RS02065	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TPSEA814_RS02095	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TPSEA814_RS02100	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TPSEA814_RS02105	COG1394	ATPase activity, coupled to movement of substances
TPSEA814_RS02110	COG1269	ATP hydrolysis coupled proton transport
TPSEA814_RS02120	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TPSEA814_RS02135	COG3015	lipoprotein NlpE involved in copper resistance
TPSEA814_RS02140	COG1227	inorganic diphosphatase activity
TPSEA814_RS02170	COG0497	DNA recombination
TPSEA814_RS02195	COG3118	belongs to the thioredoxin family
TPSEA814_RS02200	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TPSEA814_RS02205	COG0457	Tetratricopeptide repeat
TPSEA814_RS02210	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TPSEA814_RS02230	COG3706	GGDEF domain
TPSEA814_RS02250	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TPSEA814_RS02330	COG0363	glucosamine-6-phosphate deaminase activity
TPSEA814_RS02335	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TPSEA814_RS02345	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
TPSEA814_RS02350	COG2982	Protein involved in outer membrane biogenesis
TPSEA814_RS02375	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TPSEA814_RS02380	COG0840	transmembrane signaling receptor activity
TPSEA814_RS02410	COG0358	DNA primase activity
TPSEA814_RS02415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TPSEA814_RS02430	COG1077	Cell shape determining protein MreB Mrl
TPSEA814_RS02450	COG0772	Belongs to the SEDS family
TPSEA814_RS02455	COG0666	response to abiotic stimulus
TPSEA814_RS02490	COG0740	serine-type endopeptidase activity
TPSEA814_RS02500	COG0450	alkyl hydroperoxide reductase
TPSEA814_RS02510	COG1329	Transcriptional regulator
TPSEA814_RS02515	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TPSEA814_RS02515	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TPSEA814_RS02535	COG0728	peptidoglycan biosynthetic process
TPSEA814_RS02550	COG2204	response regulator
TPSEA814_RS02560	COG0470	DNA polymerase III
TPSEA814_RS02565	COG1286	toxin biosynthetic process
TPSEA814_RS02575	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TPSEA814_RS02595	COG1394	ATPase activity, coupled to movement of substances
TPSEA814_RS02600	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TPSEA814_RS02605	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TPSEA814_RS02625	COG1269	ATP hydrolysis coupled proton transport
TPSEA814_RS02630	COG1527	subunit (C
TPSEA814_RS02640	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TPSEA814_RS02660	COG1366	Belongs to the anti-sigma-factor antagonist family
TPSEA814_RS02670	COG0205	6-phosphofructokinase activity
TPSEA814_RS02690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TPSEA814_RS02735	COG0628	permease
TPSEA814_RS02740	COG0546	phosphoglycolate phosphatase activity
TPSEA814_RS02765	COG0301	tRNA thio-modification
TPSEA814_RS02770	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TPSEA814_RS02775	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
TPSEA814_RS02780	COG2089	acid synthase
TPSEA814_RS02810	COG0800	Aldolase
TPSEA814_RS02815	COG0006	proline dipeptidase activity
TPSEA814_RS02830	COG3976	FMN-binding domain protein
TPSEA814_RS02830	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
TPSEA814_RS02840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TPSEA814_RS02845	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TPSEA814_RS02855	COG0552	protein localization to endoplasmic reticulum
TPSEA814_RS02865	COG4591	ABC-type transport system involved in lipoprotein release permease component
TPSEA814_RS02870	COG1136	(ABC) transporter
TPSEA814_RS02885	COG4166	transmembrane transport
TPSEA814_RS02895	COG1466	dna polymerase III delta subunit
TPSEA814_RS02900	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TPSEA814_RS02905	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TPSEA814_RS02935	COG3064	Membrane
TPSEA814_RS02950	COG0617	tRNA 3'-terminal CCA addition
TPSEA814_RS02965	COG0750	zinc metalloprotease
TPSEA814_RS02970	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TPSEA814_RS02975	COG0575	Belongs to the CDS family
TPSEA814_RS02980	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TPSEA814_RS03005	COG1413	lyase activity
TPSEA814_RS03030	COG0719	Fe-S assembly protein
TPSEA814_RS03035	COG0719	Fe-S assembly protein
TPSEA814_RS03040	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TPSEA814_RS03085	COG0741	lytic transglycosylase activity
TPSEA814_RS03085	COG1388	LysM domain
TPSEA814_RS03110	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TPSEA814_RS03125	COG2201	protein-glutamate methylesterase activity
TPSEA814_RS03130	COG0180	Tryptophanyl-tRNA synthetase
TPSEA814_RS03135	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TPSEA814_RS03135	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TPSEA814_RS03175	COG0840	transmembrane signaling receptor activity
TPSEA814_RS03175	COG3290	protein histidine kinase activity
TPSEA814_RS03180	COG0840	transmembrane signaling receptor activity
TPSEA814_RS03190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TPSEA814_RS03195	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TPSEA814_RS03200	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
TPSEA814_RS03235	COG3842	ATPase activity
TPSEA814_RS03245	COG1177	transmembrane transport
TPSEA814_RS03280	COG0191	fructose-bisphosphate aldolase activity
TPSEA814_RS03305	COG0572	uridine kinase
TPSEA814_RS03320	COG0587	DNA-directed DNA polymerase activity
TPSEA814_RS03350	COG2840	Smr protein MutS2
TPSEA814_RS03355	COG3735	TraB family
TPSEA814_RS03375	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TPSEA814_RS03400	COG0142	geranyltranstransferase activity
TPSEA814_RS03405	COG1879	ABC-type sugar transport system periplasmic component
TPSEA814_RS03410	COG1129	ABC transporter
TPSEA814_RS03415	COG4211	Belongs to the binding-protein-dependent transport system permease family
TPSEA814_RS03420	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TPSEA814_RS03425	COG1619	proteins homologs of microcin C7 resistance protein MccF
TPSEA814_RS03440	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TPSEA814_RS03465	COG0151	Belongs to the GarS family
TPSEA814_RS03500	COG0739	heme binding
TPSEA814_RS03505	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TPSEA814_RS03505	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TPSEA814_RS03515	COG0741	lytic transglycosylase activity
TPSEA814_RS03515	COG0739	heme binding
TPSEA814_RS03515	COG1196	nuclear chromosome segregation
TPSEA814_RS03530	COG1191	sigma factor activity
TPSEA814_RS03555	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TPSEA814_RS03560	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TPSEA814_RS03570	COG1987	bacterial-type flagellum assembly
TPSEA814_RS03575	COG1338	Plays a role in the flagellum-specific transport system
TPSEA814_RS03585	COG1776	CheC inhibitor of MCP methylation
TPSEA814_RS03585	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TPSEA814_RS03590	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TPSEA814_RS03595	COG1580	Controls the rotational direction of flagella during chemotaxis
TPSEA814_RS03600	COG1360	Flagellar Motor Protein
TPSEA814_RS03605	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TPSEA814_RS03615	COG1749	Flagellar hook protein flgE
TPSEA814_RS03620	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TPSEA814_RS03650	COG0813	purine-nucleoside phosphorylase activity
TPSEA814_RS03655	COG0493	'glutamate synthase
TPSEA814_RS03660	COG0543	2 iron, 2 sulfur cluster binding
TPSEA814_RS03670	COG0799	negative regulation of ribosome biogenesis
TPSEA814_RS03710	COG0574	Belongs to the PEP-utilizing enzyme family
TPSEA814_RS03710	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TPSEA814_RS03725	COG2304	oxidoreductase activity
TPSEA814_RS03770	COG0768	penicillin binding
TPSEA814_RS03775	COG2604	Protein of unknown function DUF115
TPSEA814_RS03780	COG2604	Protein of unknown function DUF115
TPSEA814_RS03795	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TPSEA814_RS03805	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TPSEA814_RS03815	COG1652	LysM domain
TPSEA814_RS03850	COG1285	pathogenesis
TPSEA814_RS03855	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TPSEA814_RS03870	COG3956	TIGRFAM MazG family protein
TPSEA814_RS03880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TPSEA814_RS03880	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TPSEA814_RS03885	COG0739	heme binding
TPSEA814_RS03905	COG1137	ATPase activity
TPSEA814_RS03920	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TPSEA814_RS03935	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TPSEA814_RS03950	COG1477	protein flavinylation
TPSEA814_RS03955	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TPSEA814_RS03970	COG1686	Belongs to the peptidase S11 family
TPSEA814_RS03975	COG0542	response to heat
TPSEA814_RS03995	COG0557	exoribonuclease II activity
TPSEA814_RS04020	COG0338	D12 class N6 adenine-specific DNA methyltransferase
TPSEA814_RS04040	COG0492	ferredoxin-NADP+ reductase activity
TPSEA814_RS04070	COG1464	Belongs to the NlpA lipoprotein family
TPSEA814_RS04075	COG0668	transmembrane transport
TPSEA814_RS04080	COG2033	superoxide reductase activity
TPSEA814_RS04135	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TPSEA814_RS04155	COG0488	(ABC) transporter
TPSEA814_RS04170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TPSEA814_RS04175	COG0024	Methionine aminopeptidase
TPSEA814_RS04180	COG0484	heat shock protein binding
TPSEA814_RS04185	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TPSEA814_RS04190	COG1671	Belongs to the UPF0178 family
TPSEA814_RS04195	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
TPSEA814_RS04220	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TPSEA814_RS04225	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TPSEA814_RS04230	COG0455	bacterial-type flagellum organization
TPSEA814_RS04260	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TPSEA814_RS04265	COG0545	Peptidyl-prolyl cis-trans isomerase
TPSEA814_RS04270	COG1104	cysteine desulfurase activity
TPSEA814_RS04275	COG1388	LysM domain
TPSEA814_RS04275	COG3942	CHAP domain
TPSEA814_RS04295	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TPSEA814_RS04305	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TPSEA814_RS04325	COG0802	atpase or kinase
TPSEA814_RS04330	COG1214	PFAM Peptidase M22, glycoprotease
TPSEA814_RS04335	COG2770	Histidine kinase
TPSEA814_RS04335	COG3437	response regulator, receiver
TPSEA814_RS04355	COG4555	ABC transporter
TPSEA814_RS04405	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TPSEA814_RS04415	COG0779	Required for maturation of 30S ribosomal subunits
TPSEA814_RS04460	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TPSEA814_RS04470	COG1837	Belongs to the UPF0109 family
TPSEA814_RS04475	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TPSEA814_RS04480	COG0336	Belongs to the RNA methyltransferase TrmD family
TPSEA814_RS04495	COG2257	FlhB HrpN YscU SpaS Family
TPSEA814_RS04525	COG2239	Acts as a magnesium transporter
TPSEA814_RS04535	COG3118	belongs to the thioredoxin family
TPSEA814_RS04540	COG0457	Tetratricopeptide repeat
TPSEA814_RS04575	COG0716	FMN binding
TPSEA814_RS04580	COG0681	Belongs to the peptidase S26 family
TPSEA814_RS04590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TPSEA814_RS04595	COG2604	Protein of unknown function DUF115
TPSEA814_RS04625	COG1253	flavin adenine dinucleotide binding
TPSEA814_RS04640	COG0674	pyruvate-flavodoxin oxidoreductase activity
TPSEA814_RS04640	COG1013	pyruvate-flavodoxin oxidoreductase activity
TPSEA814_RS04640	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TPSEA814_RS04640	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TPSEA814_RS04665	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TPSEA814_RS04675	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TPSEA814_RS04680	COG1847	R3H domain protein
TPSEA814_RS04685	COG0706	membrane insertase activity
TPSEA814_RS04690	COG0594	ribonuclease P activity
TPSEA814_RS04730	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TPSEA814_RS04730	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TPSEA814_RS04735	COG3951	Flagellar rod assembly protein muramidase FlgJ
TPSEA814_RS04755	COG1136	(ABC) transporter
TPSEA814_RS04755	COG0577	efflux transmembrane transporter activity
TPSEA814_RS04760	COG1136	(ABC) transporter
TPSEA814_RS04765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TPSEA814_RS04790	COG3470	protein probably involved in high-affinity Fe2 transport
TPSEA814_RS04795	COG0672	)-iron permease
TPSEA814_RS04810	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TPSEA814_RS04820	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TPSEA814_RS04825	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TPSEA814_RS04830	COG0084	hydrolase, TatD family'
TPSEA814_RS04835	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TPSEA814_RS04835	COG3116	cell division
TPSEA814_RS04855	COG0326	Molecular chaperone. Has ATPase activity
TPSEA814_RS04875	COG2095	MarC family integral membrane protein
TPSEA814_RS04890	COG1773	rubredoxin
TPSEA814_RS04900	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TPSEA814_RS04910	COG0084	hydrolase, TatD family'
TPSEA814_RS04930	COG0616	signal peptide processing
TPSEA814_RS04935	COG1115	amino acid carrier protein
TPSEA814_RS04940	COG1674	ftsk spoiiie
TPSEA814_RS04965	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TPSEA814_RS04970	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TPSEA814_RS04975	COG0187	DNA topoisomerase II activity
TPSEA814_RS04980	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TPSEA814_RS04985	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TPSEA814_RS05005	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TPSEA814_RS05025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TPSEA814_RS05030	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TPSEA814_RS05040	COG1418	mRNA catabolic process
TPSEA814_RS05045	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TPSEA814_RS05060	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TPSEA814_RS05095	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
TPSEA814_RS05105	COG0724	RNA recognition motif
TPSEA814_RS05115	COG5341	Protein conserved in bacteria
TPSEA814_RS05120	COG1752	Esterase of the alpha-beta hydrolase superfamily
TPSEA814_RS05125	COG0530	calcium, potassium:sodium antiporter activity
TPSEA814_RS05130	COG0525	valine-tRNA ligase activity
TPSEA814_RS05140	COG1272	protein, Hemolysin III
TPSEA814_RS05145	COG0783	Belongs to the Dps family
TPSEA814_RS05155	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
TPSEA814_RS05160	COG0740	serine-type endopeptidase activity