locus-tag	class	description
IFE08_RS00005	COG0330	HflC and HflK could
IFE08_RS00015	COG0215	cysteine-tRNA ligase activity
IFE08_RS00030	COG1305	Transglutaminase-like
IFE08_RS00035	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IFE08_RS00040	COG0095	Lipoate-protein ligase
IFE08_RS00045	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IFE08_RS00045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IFE08_RS00050	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IFE08_RS00055	COG1690	Belongs to the RtcB family
IFE08_RS00060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IFE08_RS00065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IFE08_RS00070	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IFE08_RS00075	COG1301	dicarboxylic acid transport
IFE08_RS00100	COG1254	Belongs to the acylphosphatase family
IFE08_RS00105	COG1115	amino acid carrier protein
IFE08_RS00110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IFE08_RS00115	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IFE08_RS00125	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IFE08_RS00130	COG1393	Belongs to the ArsC family
IFE08_RS00155	COG1366	Belongs to the anti-sigma-factor antagonist family
IFE08_RS00160	COG1876	peptidase activity
IFE08_RS00180	COG1472	Belongs to the glycosyl hydrolase 3 family
IFE08_RS00200	COG0423	glycine-tRNA ligase activity
IFE08_RS00215	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IFE08_RS00225	COG1228	amidohydrolase
IFE08_RS00235	COG4946	Tricorn protease homolog
IFE08_RS00235	COG1506	peptidase
IFE08_RS00235	COG0823	Involved in the tonB-independent uptake of proteins
IFE08_RS00260	COG0556	nucleotide-excision repair
IFE08_RS00285	COG2239	Acts as a magnesium transporter
IFE08_RS00295	COG1755	Isoprenylcysteine carboxyl methyltransferase
IFE08_RS00315	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IFE08_RS00340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IFE08_RS00345	COG0444	Belongs to the ABC transporter superfamily
IFE08_RS00350	COG4608	Belongs to the ABC transporter superfamily
IFE08_RS00395	COG0167	dihydroorotate dehydrogenase activity
IFE08_RS00400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IFE08_RS00410	COG0701	Predicted permease
IFE08_RS00435	COG0587	DNA-directed DNA polymerase activity
IFE08_RS00440	COG1028	Short-chain dehydrogenase reductase Sdr
IFE08_RS00470	COG4555	ABC transporter
IFE08_RS00505	COG0574	Belongs to the PEP-utilizing enzyme family
IFE08_RS00505	COG3848	Pyruvate phosphate dikinase
IFE08_RS00530	COG0730	response to heat
IFE08_RS00540	COG1959	2 iron, 2 sulfur cluster binding
IFE08_RS00545	COG2910	NAD(P)H-binding
IFE08_RS00550	COG2089	acid synthase
IFE08_RS00565	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IFE08_RS00585	COG1120	ATPase activity
IFE08_RS00625	COG0783	Belongs to the Dps family
IFE08_RS00630	COG0840	transmembrane signaling receptor activity
IFE08_RS00640	COG0425	Belongs to the sulfur carrier protein TusA family
IFE08_RS00665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IFE08_RS00680	COG1136	(ABC) transporter
IFE08_RS00685	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
IFE08_RS00710	COG0629	single-stranded DNA binding
IFE08_RS00715	COG1691	(AIR) carboxylase
IFE08_RS00740	COG0601	transmembrane transport
IFE08_RS00745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IFE08_RS00750	COG0444	Belongs to the ABC transporter superfamily
IFE08_RS00755	COG4172	Belongs to the ABC transporter superfamily
IFE08_RS00760	COG1132	(ABC) transporter
IFE08_RS00765	COG1132	(ABC) transporter
IFE08_RS00790	COG1185	polyribonucleotide nucleotidyltransferase activity
IFE08_RS00795	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IFE08_RS00800	COG0196	riboflavin kinase activity
IFE08_RS00805	COG0840	transmembrane signaling receptor activity
IFE08_RS00830	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IFE08_RS00845	COG2233	PERMEase
IFE08_RS00855	COG0671	phosphoesterase, PA-phosphatase related
IFE08_RS00860	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IFE08_RS00885	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IFE08_RS00925	COG0546	phosphoglycolate phosphatase activity
IFE08_RS00930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IFE08_RS00935	COG4166	transmembrane transport
IFE08_RS00955	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IFE08_RS01055	COG0789	Transcriptional regulator
IFE08_RS01080	COG1959	2 iron, 2 sulfur cluster binding
IFE08_RS01090	COG2910	NAD(P)H-binding
IFE08_RS01195	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IFE08_RS01200	COG0826	peptidase U32
IFE08_RS01205	COG1606	tRNA processing
IFE08_RS01210	COG1132	(ABC) transporter
IFE08_RS01225	COG1132	(ABC) transporter
IFE08_RS01245	COG1475	DNA binding
IFE08_RS01250	COG1192	Involved in chromosome partitioning
IFE08_RS01265	COG0840	transmembrane signaling receptor activity
IFE08_RS01280	COG1802	Transcriptional regulator
IFE08_RS01300	COG0511	ligase activity, forming carbon-carbon bonds
IFE08_RS01305	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
IFE08_RS01315	COG2301	Belongs to the HpcH HpaI aldolase family
IFE08_RS01320	COG3051	citrate lyase alpha subunit
IFE08_RS01335	COG0616	signal peptide processing
IFE08_RS01340	COG0012	GTP binding
IFE08_RS01345	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IFE08_RS01350	COG1744	ABC transporter substrate-binding protein PnrA-like
IFE08_RS01355	COG3845	ABC transporter
IFE08_RS01360	COG4603	Belongs to the binding-protein-dependent transport system permease family
IFE08_RS01365	COG1079	Belongs to the binding-protein-dependent transport system permease family
IFE08_RS01375	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IFE08_RS01420	COG0280	phosphate acetyltransferase
IFE08_RS01425	COG0457	Tetratricopeptide repeat
IFE08_RS01435	COG0542	response to heat
IFE08_RS01450	COG0101	tRNA pseudouridine synthase activity
IFE08_RS01460	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
IFE08_RS01470	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IFE08_RS01480	COG0840	transmembrane signaling receptor activity
IFE08_RS01490	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IFE08_RS01495	COG0740	serine-type endopeptidase activity
IFE08_RS01500	COG0544	peptidyl-prolyl cis-trans isomerase activity
IFE08_RS01515	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IFE08_RS01520	COG2211	Major facilitator Superfamily
IFE08_RS01530	COG2201	protein-glutamate methylesterase activity
IFE08_RS01540	COG0835	chemotaxis
IFE08_RS01545	COG0643	Histidine kinase
IFE08_RS01545	COG2198	Histidine kinase
IFE08_RS01560	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IFE08_RS01575	COG0316	Belongs to the HesB IscA family
IFE08_RS01575	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IFE08_RS01580	COG0756	dUTP diphosphatase activity
IFE08_RS01585	COG3330	Domain of unknown function (DUF4912)
IFE08_RS01600	COG0543	2 iron, 2 sulfur cluster binding
IFE08_RS01620	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IFE08_RS01630	COG2080	2 iron, 2 sulfur cluster binding
IFE08_RS01645	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IFE08_RS01650	COG1987	bacterial-type flagellum assembly
IFE08_RS01655	COG1684	flagellar biosynthetic protein fliR
IFE08_RS01660	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IFE08_RS01665	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IFE08_RS01680	COG2217	Heavy metal translocating P-type atpase
IFE08_RS01710	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IFE08_RS01725	COG4545	Glutaredoxin-related protein
IFE08_RS01730	COG0739	heme binding
IFE08_RS01735	COG1418	mRNA catabolic process
IFE08_RS01765	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IFE08_RS01770	COG4139	cobalamin transport
IFE08_RS01775	COG1120	ATPase activity
IFE08_RS01800	COG0840	transmembrane signaling receptor activity
IFE08_RS01805	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IFE08_RS01810	COG2703	oxygen carrier activity
IFE08_RS01860	COG1120	ATPase activity
IFE08_RS01875	COG0840	transmembrane signaling receptor activity
IFE08_RS02000	COG0840	transmembrane signaling receptor activity
IFE08_RS02005	COG4656	Part of a membrane complex involved in electron transport
IFE08_RS02010	COG4658	electron transport chain
IFE08_RS02015	COG4659	FMN binding
IFE08_RS02020	COG4660	Part of a membrane complex involved in electron transport
IFE08_RS02025	COG4657	Part of a membrane complex involved in electron transport
IFE08_RS02045	COG0792	nuclease activity
IFE08_RS02055	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IFE08_RS02065	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IFE08_RS02075	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IFE08_RS02080	COG0564	pseudouridine synthase activity
IFE08_RS02085	COG0357	Ribosomal RNA small subunit methyltransferase G
IFE08_RS02090	COG1012	belongs to the aldehyde dehydrogenase family
IFE08_RS02100	COG1012	belongs to the aldehyde dehydrogenase family
IFE08_RS02105	COG1757	Na H antiporter
IFE08_RS02110	COG0488	(ABC) transporter
IFE08_RS02115	COG1132	(ABC) transporter
IFE08_RS02120	COG4865	methylaspartate mutase activity
IFE08_RS02140	COG0724	RNA recognition motif
IFE08_RS02150	COG0534	Mate efflux family protein
IFE08_RS02155	COG0420	3'-5' exonuclease activity
IFE08_RS02160	COG0419	ATPase involved in DNA repair
IFE08_RS02195	COG1187	pseudouridine synthase activity
IFE08_RS02235	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IFE08_RS02240	COG0154	amidase activity
IFE08_RS02260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IFE08_RS02275	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IFE08_RS02275	COG0426	domain, Protein
IFE08_RS02305	COG3118	belongs to the thioredoxin family
IFE08_RS02315	COG1272	protein, Hemolysin III
IFE08_RS02330	COG1047	Peptidyl-prolyl cis-trans
IFE08_RS02370	COG0644	oxidoreductase
IFE08_RS02375	COG2226	methyltransferase
IFE08_RS02385	COG0142	geranyltranstransferase activity
IFE08_RS02410	COG0003	Pfam Anion-transporting ATPase
IFE08_RS02415	COG1620	l-lactate permease
IFE08_RS02425	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IFE08_RS02660	COG0588	phosphoglycerate mutase activity
IFE08_RS02675	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IFE08_RS02695	COG3177	Filamentation induced by cAMP protein fic
IFE08_RS02795	COG0813	purine-nucleoside phosphorylase activity
IFE08_RS02925	COG1132	(ABC) transporter
IFE08_RS02995	COG2207	Transcriptional regulator
IFE08_RS03005	COG1132	(ABC) transporter
IFE08_RS03070	COG1129	ABC transporter
IFE08_RS03075	COG3493	citrate carrier protein
IFE08_RS03080	COG1879	ABC-type sugar transport system periplasmic component
IFE08_RS03085	COG1840	ABC-type Fe3 transport system, periplasmic component
IFE08_RS03090	COG0438	transferase activity, transferring glycosyl groups
IFE08_RS03095	COG3842	ATPase activity
IFE08_RS03105	COG0148	phosphopyruvate hydratase activity
IFE08_RS03115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IFE08_RS03120	COG1116	anion transmembrane transporter activity
IFE08_RS03160	COG0569	domain protein
IFE08_RS03165	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IFE08_RS03170	COG0504	CTP synthase activity
IFE08_RS03180	COG0574	Belongs to the PEP-utilizing enzyme family
IFE08_RS03180	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IFE08_RS03205	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IFE08_RS03220	COG0840	transmembrane signaling receptor activity
IFE08_RS03265	COG4208	sulfate ABC transporter
IFE08_RS03285	COG0726	polysaccharide deacetylase
IFE08_RS03295	COG1122	ATPase activity
IFE08_RS03300	COG1268	BioY protein
IFE08_RS03310	COG1652	LysM domain
IFE08_RS03315	COG0517	IMP dehydrogenase activity
IFE08_RS03315	COG0516	GMP reductase activity
IFE08_RS03330	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
IFE08_RS03365	COG0569	domain protein
IFE08_RS03370	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IFE08_RS03400	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IFE08_RS03415	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IFE08_RS03435	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IFE08_RS03445	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IFE08_RS03460	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IFE08_RS03470	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IFE08_RS03510	COG2226	methyltransferase
IFE08_RS03540	COG4555	ABC transporter
IFE08_RS03560	COG1132	(ABC) transporter
IFE08_RS03565	COG1132	(ABC) transporter
IFE08_RS03575	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IFE08_RS03580	COG3876	Protein conserved in bacteria
IFE08_RS03585	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IFE08_RS03635	COG1122	ATPase activity
IFE08_RS03655	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IFE08_RS03655	COG1918	ferrous iron import across plasma membrane
IFE08_RS03720	COG0737	Belongs to the 5'-nucleotidase family
IFE08_RS03735	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IFE08_RS03745	COG0632	four-way junction helicase activity
IFE08_RS03750	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IFE08_RS03765	COG0519	Catalyzes the synthesis of GMP from XMP
IFE08_RS03800	COG0582	viral genome integration into host DNA
IFE08_RS03845	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IFE08_RS03850	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IFE08_RS03865	COG0577	efflux transmembrane transporter activity
IFE08_RS03865	COG1136	(ABC) transporter
IFE08_RS03870	COG0577	efflux transmembrane transporter activity
IFE08_RS03870	COG1136	(ABC) transporter
IFE08_RS03875	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IFE08_RS03880	COG2217	Heavy metal translocating P-type atpase
IFE08_RS03890	COG0525	valine-tRNA ligase activity
IFE08_RS03895	COG1132	(ABC) transporter
IFE08_RS03910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IFE08_RS03920	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IFE08_RS03930	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IFE08_RS03935	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IFE08_RS03950	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
IFE08_RS03960	COG1924	4 iron, 4 sulfur cluster binding
IFE08_RS03965	COG0840	transmembrane signaling receptor activity
IFE08_RS04005	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IFE08_RS04015	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IFE08_RS04020	COG0250	Participates in transcription elongation, termination and antitermination
IFE08_RS04025	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IFE08_RS04030	COG0081	regulation of translation
IFE08_RS04035	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IFE08_RS04040	COG0222	ribosome binding
IFE08_RS04045	COG0085	RNA polymerase activity
IFE08_RS04050	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IFE08_RS04060	COG0322	excinuclease ABC activity
IFE08_RS04080	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IFE08_RS04100	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IFE08_RS04105	COG4585	Histidine kinase
IFE08_RS04120	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IFE08_RS04130	COG1363	Peptidase, m42
IFE08_RS04155	COG1022	Amp-dependent synthetase and ligase
IFE08_RS04165	COG1309	transcriptional regulator
IFE08_RS04170	COG0786	glutamate:sodium symporter activity
IFE08_RS04175	COG1132	(ABC) transporter
IFE08_RS04190	COG1129	ABC transporter
IFE08_RS04215	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
IFE08_RS04220	COG1394	ATPase activity, coupled to movement of substances
IFE08_RS04235	COG1692	metallophosphoesterase
IFE08_RS04245	COG4750	Nucleotidyl transferase
IFE08_RS04265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IFE08_RS04270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IFE08_RS04280	COG0588	phosphoglycerate mutase activity
IFE08_RS04295	COG2033	superoxide reductase activity
IFE08_RS04305	COG0534	Mate efflux family protein
IFE08_RS04330	COG1450	Type ii and iii secretion system protein
IFE08_RS04535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IFE08_RS04540	COG0601	transmembrane transport
IFE08_RS04545	COG0747	negative chemotaxis
IFE08_RS04550	COG1917	Cupin 2, conserved barrel domain protein
IFE08_RS04550	COG4977	sequence-specific DNA binding
IFE08_RS04555	COG0840	transmembrane signaling receptor activity
IFE08_RS04600	COG0455	bacterial-type flagellum organization
IFE08_RS04610	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IFE08_RS04615	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IFE08_RS04615	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IFE08_RS04640	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IFE08_RS04655	COG3949	Membrane
IFE08_RS04670	COG0840	transmembrane signaling receptor activity
IFE08_RS04675	COG0542	response to heat
IFE08_RS04680	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IFE08_RS04700	COG0768	penicillin binding
IFE08_RS04725	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IFE08_RS04740	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IFE08_RS04745	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IFE08_RS04750	COG0037	tRNA processing
IFE08_RS04755	COG0457	Tetratricopeptide repeat
IFE08_RS04760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IFE08_RS04765	COG1073	alpha beta
IFE08_RS04790	COG1373	ATPase (AAA superfamily
IFE08_RS04810	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IFE08_RS04845	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IFE08_RS04855	COG1181	Belongs to the D-alanine--D-alanine ligase family
IFE08_RS04860	COG2089	acid synthase
IFE08_RS04875	COG1083	cytidylyl-transferase
IFE08_RS04885	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IFE08_RS04945	COG1216	Glycosyl transferase, family 2
IFE08_RS04950	COG1216	Glycosyl transferase, family 2
IFE08_RS04995	COG1760	l-serine dehydratase
IFE08_RS05000	COG1760	l-serine dehydratase
IFE08_RS05005	COG1114	Component of the transport system for branched-chain amino acids
IFE08_RS05020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IFE08_RS05060	COG2855	membrane
IFE08_RS05070	COG1129	ABC transporter
IFE08_RS05090	COG2342	PFAM TM1410 hypothetical-related protein
IFE08_RS05095	COG1744	ABC transporter substrate-binding protein PnrA-like
IFE08_RS05100	COG3845	ABC transporter
IFE08_RS05105	COG4603	Belongs to the binding-protein-dependent transport system permease family
IFE08_RS05110	COG1079	Belongs to the binding-protein-dependent transport system permease family
IFE08_RS05125	COG0126	phosphoglycerate kinase activity
IFE08_RS05130	COG0860	N-Acetylmuramoyl-L-alanine amidase
IFE08_RS05150	COG0268	Binds directly to 16S ribosomal RNA
IFE08_RS05160	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IFE08_RS05170	COG1058	Belongs to the CinA family
IFE08_RS05170	COG1546	Belongs to the CinA family
IFE08_RS05180	COG3681	Belongs to the UPF0597 family
IFE08_RS05185	COG0840	transmembrane signaling receptor activity
IFE08_RS05190	COG0617	tRNA 3'-terminal CCA addition
IFE08_RS05200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IFE08_RS05210	COG1132	(ABC) transporter
IFE08_RS05215	COG1132	(ABC) transporter
IFE08_RS05240	COG0343	queuine tRNA-ribosyltransferase activity
IFE08_RS05260	COG0359	binds to the 23S rRNA
IFE08_RS05265	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IFE08_RS05270	COG0629	single-stranded DNA binding
IFE08_RS05275	COG0360	Binds together with S18 to 16S ribosomal RNA
IFE08_RS05335	COG3209	COG3209 Rhs family protein
IFE08_RS05345	COG3209	COG3209 Rhs family protein
IFE08_RS05345	COG4104	PAAR repeat-containing protein
IFE08_RS05380	COG3209	COG3209 Rhs family protein
IFE08_RS05385	COG2252	PERMEase
IFE08_RS05400	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
IFE08_RS05410	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IFE08_RS05415	COG0071	Belongs to the small heat shock protein (HSP20) family
IFE08_RS05420	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IFE08_RS05445	COG1132	(ABC) transporter
IFE08_RS05450	COG1132	(ABC) transporter
IFE08_RS05455	COG1120	ATPase activity
IFE08_RS05460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IFE08_RS05465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IFE08_RS05470	COG0840	transmembrane signaling receptor activity
IFE08_RS05475	COG2201	protein-glutamate methylesterase activity
IFE08_RS05500	COG1137	ATPase activity
IFE08_RS05505	COG1053	succinate dehydrogenase
IFE08_RS05505	COG0431	NADPH-dependent FMN reductase
IFE08_RS05505	COG3976	FMN-binding domain protein
IFE08_RS05510	COG1418	mRNA catabolic process
IFE08_RS05520	COG2195	Cleaves the N-terminal amino acid of tripeptides
IFE08_RS05525	COG0124	histidyl-tRNA synthetase
IFE08_RS05535	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IFE08_RS05545	COG1193	negative regulation of DNA recombination
IFE08_RS05555	COG3706	GGDEF domain
IFE08_RS05610	COG3033	Beta-eliminating lyase
IFE08_RS05615	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IFE08_RS05625	COG3639	organic phosphonate transmembrane transporter activity
IFE08_RS05630	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
IFE08_RS05655	COG0019	diaminopimelate decarboxylase activity
IFE08_RS05660	COG0433	COG0433 Predicted ATPase
IFE08_RS05670	COG4608	Belongs to the ABC transporter superfamily
IFE08_RS05675	COG0444	Belongs to the ABC transporter superfamily
IFE08_RS05680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IFE08_RS05685	COG0601	transmembrane transport
IFE08_RS05690	COG0747	negative chemotaxis
IFE08_RS05695	COG0840	transmembrane signaling receptor activity
IFE08_RS05700	COG4106	trans-aconitate 2-methyltransferase activity
IFE08_RS05705	COG1269	ATP hydrolysis coupled proton transport
IFE08_RS05720	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IFE08_RS05720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IFE08_RS05720	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IFE08_RS05725	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IFE08_RS05735	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IFE08_RS05740	COG2890	protein-(glutamine-N5) methyltransferase activity
IFE08_RS05760	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IFE08_RS05765	COG2088	sporulation resulting in formation of a cellular spore
IFE08_RS05775	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IFE08_RS05780	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IFE08_RS05790	COG1592	Rubrerythrin
IFE08_RS05795	COG1283	sodium-dependent phosphate transmembrane transporter activity
IFE08_RS05815	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IFE08_RS05820	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IFE08_RS05825	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IFE08_RS05870	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IFE08_RS05880	COG0719	Fe-S assembly protein
IFE08_RS05890	COG0583	DNA-binding transcription factor activity
IFE08_RS05895	COG1131	(ABC) transporter
IFE08_RS05905	COG1132	(ABC) transporter
IFE08_RS05925	COG1266	CAAX protease self-immunity
IFE08_RS05940	COG0495	leucyl-tRNA aminoacylation
IFE08_RS05970	COG1196	nuclear chromosome segregation
IFE08_RS05980	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IFE08_RS06005	COG1450	Type ii and iii secretion system protein
IFE08_RS06195	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IFE08_RS06210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IFE08_RS06220	COG0006	proline dipeptidase activity
IFE08_RS06230	COG1181	Belongs to the D-alanine--D-alanine ligase family
IFE08_RS06235	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IFE08_RS06235	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IFE08_RS06240	COG1102	Psort location Cytoplasmic, score
IFE08_RS06245	COG1561	YicC-like family, N-terminal region
IFE08_RS06255	COG0285	dihydrofolate synthase activity
IFE08_RS06260	COG0564	pseudouridine synthase activity
IFE08_RS06275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IFE08_RS06290	COG0803	Belongs to the bacterial solute-binding protein 9 family
IFE08_RS06300	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IFE08_RS06305	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IFE08_RS06305	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IFE08_RS06310	COG1196	nuclear chromosome segregation
IFE08_RS06310	COG0741	lytic transglycosylase activity
IFE08_RS06310	COG0739	heme binding
IFE08_RS06320	COG1595	DNA-templated transcription, initiation
IFE08_RS06335	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IFE08_RS06340	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IFE08_RS06345	COG1966	Carbon starvation protein
IFE08_RS06350	COG3956	TIGRFAM MazG family protein
IFE08_RS06365	COG0793	Belongs to the peptidase S41A family
IFE08_RS06370	COG0534	Mate efflux family protein
IFE08_RS06380	COG0549	Belongs to the carbamate kinase family
IFE08_RS06390	COG0823	Involved in the tonB-independent uptake of proteins
IFE08_RS06400	COG1199	ATP-dependent helicase activity
IFE08_RS06490	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IFE08_RS06500	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IFE08_RS06510	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IFE08_RS06520	COG0488	(ABC) transporter
IFE08_RS06545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IFE08_RS06550	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IFE08_RS06555	COG0058	SHG alpha-glucan phosphorylase activity
IFE08_RS06575	COG0237	dephospho-CoA kinase activity
IFE08_RS06580	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IFE08_RS06580	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IFE08_RS06580	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IFE08_RS06590	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IFE08_RS06595	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IFE08_RS06620	COG0398	Pfam SNARE associated Golgi protein
IFE08_RS06630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IFE08_RS06645	COG0668	transmembrane transport
IFE08_RS06670	COG2897	thiosulfate sulfurtransferase activity
IFE08_RS06715	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IFE08_RS06715	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IFE08_RS06720	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IFE08_RS06725	COG0358	DNA primase activity
IFE08_RS06730	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IFE08_RS06750	COG1077	Cell shape determining protein MreB Mrl
IFE08_RS06765	COG0768	penicillin binding
IFE08_RS06770	COG0772	Belongs to the SEDS family
IFE08_RS06790	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
IFE08_RS06795	COG0840	transmembrane signaling receptor activity
IFE08_RS06805	COG1269	ATP hydrolysis coupled proton transport
IFE08_RS06810	COG1394	ATPase activity, coupled to movement of substances
IFE08_RS06815	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
IFE08_RS06820	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
IFE08_RS06825	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IFE08_RS06845	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IFE08_RS06860	COG4555	ABC transporter
IFE08_RS06900	COG0217	transcriptional regulatory protein
IFE08_RS06905	COG0138	bifunctional purine biosynthesis protein purh
IFE08_RS06915	COG1362	aminopeptidase activity
IFE08_RS06935	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IFE08_RS06945	COG1115	amino acid carrier protein
IFE08_RS06960	COG0799	negative regulation of ribosome biogenesis
IFE08_RS06965	COG2059	Chromate
IFE08_RS06985	COG1480	7TM receptor with intracellular HD hydrolase
IFE08_RS06990	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IFE08_RS07000	COG2885	chlorophyll binding
IFE08_RS07005	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IFE08_RS07015	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IFE08_RS07025	COG0509	glycine decarboxylation via glycine cleavage system
IFE08_RS07035	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IFE08_RS07040	COG1722	exodeoxyribonuclease VII activity
IFE08_RS07045	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IFE08_RS07050	COG2161	toxin-antitoxin pair type II binding
IFE08_RS07075	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IFE08_RS07100	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IFE08_RS07110	COG1773	rubredoxin
IFE08_RS07130	COG1692	metallophosphoesterase
IFE08_RS07150	COG4555	ABC transporter
IFE08_RS07180	COG1115	amino acid carrier protein
IFE08_RS07195	COG2195	Cleaves the N-terminal amino acid of tripeptides
IFE08_RS07205	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IFE08_RS07210	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IFE08_RS07225	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IFE08_RS07230	COG0156	8-amino-7-oxononanoate synthase activity
IFE08_RS07235	COG2878	Part of a membrane complex involved in electron transport
IFE08_RS07240	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IFE08_RS07245	COG2183	response to ionizing radiation
IFE08_RS07250	COG1363	Peptidase, m42
IFE08_RS07255	COG0281	malic enzyme
IFE08_RS07270	COG2738	Putative neutral zinc metallopeptidase
IFE08_RS07275	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IFE08_RS07275	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
IFE08_RS07290	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
IFE08_RS07295	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IFE08_RS07310	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IFE08_RS07315	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IFE08_RS07390	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IFE08_RS07395	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IFE08_RS07395	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IFE08_RS07400	COG1329	Transcriptional regulator
IFE08_RS07415	COG1136	(ABC) transporter
IFE08_RS07415	COG0577	efflux transmembrane transporter activity
IFE08_RS07425	COG1136	(ABC) transporter
IFE08_RS07435	COG0009	L-threonylcarbamoyladenylate synthase
IFE08_RS07470	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
IFE08_RS07475	COG2204	response regulator
IFE08_RS07480	COG0539	negative regulation of cytoplasmic translation
IFE08_RS07500	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IFE08_RS07520	COG0497	DNA recombination
IFE08_RS07540	COG1388	LysM domain
IFE08_RS07545	COG1757	Na H antiporter
IFE08_RS07550	COG0626	cystathionine gamma-synthase activity
IFE08_RS07570	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IFE08_RS07580	COG0488	(ABC) transporter
IFE08_RS07585	COG2723	6-phospho-beta-galactosidase activity
IFE08_RS07590	COG2190	(PTS) system
IFE08_RS07590	COG2211	Major facilitator Superfamily
IFE08_RS07605	COG0557	exoribonuclease II activity
IFE08_RS07630	COG2017	converts alpha-aldose to the beta-anomer
IFE08_RS07640	COG1162	GTPase activity
IFE08_RS07645	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IFE08_RS07655	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
IFE08_RS07660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IFE08_RS07670	COG2255	four-way junction helicase activity
IFE08_RS07675	COG1979	alcohol dehydrogenase
IFE08_RS07680	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IFE08_RS07695	COG3880	PFAM UvrB UvrC protein
IFE08_RS07705	COG1136	(ABC) transporter
IFE08_RS07720	COG0552	protein localization to endoplasmic reticulum
IFE08_RS07735	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IFE08_RS07750	COG0840	transmembrane signaling receptor activity
IFE08_RS07755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IFE08_RS07770	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IFE08_RS07775	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IFE08_RS07785	COG2056	Na+-H+ antiporter family
IFE08_RS07800	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IFE08_RS07805	COG1309	transcriptional regulator
IFE08_RS07810	COG1132	(ABC) transporter
IFE08_RS07815	COG1129	ABC transporter
IFE08_RS07830	COG0488	(ABC) transporter
IFE08_RS07895	COG4608	Belongs to the ABC transporter superfamily
IFE08_RS07900	COG0444	Belongs to the ABC transporter superfamily
IFE08_RS07905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IFE08_RS07910	COG0601	transmembrane transport
IFE08_RS07920	COG0312	modulator of DNA gyrase
IFE08_RS07945	COG2604	Protein of unknown function DUF115
IFE08_RS07950	COG0484	heat shock protein binding
IFE08_RS07955	COG0443	Heat shock 70 kDa protein
IFE08_RS07960	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IFE08_RS07965	COG0284	orotidine-5'-phosphate decarboxylase activity
IFE08_RS07975	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IFE08_RS07980	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IFE08_RS07990	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IFE08_RS08000	COG0825	malonyl-CoA metabolic process
IFE08_RS08005	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IFE08_RS08010	COG0439	Biotin carboxylase
IFE08_RS08015	COG0511	ligase activity, forming carbon-carbon bonds
IFE08_RS08020	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IFE08_RS08025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IFE08_RS08030	COG1028	Short-chain dehydrogenase reductase Sdr
IFE08_RS08035	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IFE08_RS08050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IFE08_RS08060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IFE08_RS08070	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IFE08_RS08095	COG0330	HflC and HflK could
IFE08_RS08100	COG0330	HflC and HflK could
IFE08_RS08110	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
IFE08_RS08130	COG0835	chemotaxis
IFE08_RS08140	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IFE08_RS08145	COG1132	(ABC) transporter
IFE08_RS08150	COG2084	Dehydrogenase
IFE08_RS08155	COG2986	histidine ammonia-lyase
IFE08_RS08165	COG1131	(ABC) transporter
IFE08_RS08185	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IFE08_RS08285	COG0840	transmembrane signaling receptor activity
IFE08_RS08300	COG0840	transmembrane signaling receptor activity
IFE08_RS08310	COG0840	transmembrane signaling receptor activity
IFE08_RS08320	COG0840	transmembrane signaling receptor activity
IFE08_RS08325	COG0840	transmembrane signaling receptor activity
IFE08_RS08335	COG0840	transmembrane signaling receptor activity
IFE08_RS08360	COG4115	mRNA cleavage
IFE08_RS08460	COG0442	prolyl-tRNA aminoacylation
IFE08_RS08465	COG4608	Belongs to the ABC transporter superfamily
IFE08_RS08470	COG0444	Belongs to the ABC transporter superfamily
IFE08_RS08475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IFE08_RS08480	COG0601	transmembrane transport
IFE08_RS08485	COG4166	transmembrane transport
IFE08_RS08500	COG2982	Protein involved in outer membrane biogenesis
IFE08_RS08505	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
IFE08_RS08510	COG0297	glycogen (starch) synthase activity
IFE08_RS08520	COG4475	Protein of unknown function (DUF436)
IFE08_RS08535	COG1472	Belongs to the glycosyl hydrolase 3 family
IFE08_RS08550	COG1157	protein secretion by the type III secretion system
IFE08_RS08555	COG1317	bacterial-type flagellum organization
IFE08_RS08565	COG1766	The M ring may be actively involved in energy transduction
IFE08_RS08570	COG1677	Flagellar hook-basal body complex protein FliE
IFE08_RS08585	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IFE08_RS08590	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IFE08_RS08595	COG4974	Belongs to the 'phage' integrase family
IFE08_RS08600	COG0551	DNA topoisomerase type I activity
IFE08_RS08600	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IFE08_RS08605	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IFE08_RS08605	COG0758	DNA mediated transformation
IFE08_RS08620	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IFE08_RS08635	COG0772	Belongs to the SEDS family
IFE08_RS08640	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IFE08_RS08650	COG0275	rRNA processing
IFE08_RS08655	COG2001	Belongs to the MraZ family
IFE08_RS08680	COG0513	Belongs to the DEAD box helicase family
IFE08_RS08705	COG1739	Uncharacterized protein family UPF0029
IFE08_RS08725	COG0747	negative chemotaxis
IFE08_RS08730	COG0601	transmembrane transport
IFE08_RS08735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IFE08_RS08750	COG2226	methyltransferase
IFE08_RS08755	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IFE08_RS08765	COG0481	GTPase activity
IFE08_RS08780	COG0750	zinc metalloprotease
IFE08_RS08785	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IFE08_RS08790	COG0575	Belongs to the CDS family
IFE08_RS08795	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IFE08_RS08800	COG0233	cytoplasmic translational termination
IFE08_RS08805	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IFE08_RS08810	COG0052	Belongs to the universal ribosomal protein uS2 family
IFE08_RS08865	COG4104	PAAR repeat-containing protein
IFE08_RS08865	COG3209	COG3209 Rhs family protein
IFE08_RS08875	COG4104	PAAR repeat-containing protein
IFE08_RS08875	COG3209	COG3209 Rhs family protein
IFE08_RS08965	COG0840	transmembrane signaling receptor activity
IFE08_RS08975	COG0312	modulator of DNA gyrase
IFE08_RS08980	COG0312	modulator of DNA gyrase
IFE08_RS08985	COG3052	prosthetic group binding
IFE08_RS08995	COG3051	citrate lyase alpha subunit
IFE08_RS09010	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IFE08_RS09015	COG0484	heat shock protein binding
IFE08_RS09020	COG0528	UMP kinase activity
IFE08_RS09025	COG0736	holo-[acyl-carrier-protein] synthase activity
IFE08_RS09035	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
IFE08_RS09040	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IFE08_RS09045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IFE08_RS09050	COG0424	maF-like protein
IFE08_RS09055	COG1413	lyase activity
IFE08_RS09065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IFE08_RS09070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IFE08_RS09075	COG1334	flagellar protein FlaG
IFE08_RS09080	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IFE08_RS09080	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IFE08_RS09095	COG0802	atpase or kinase
IFE08_RS09105	COG3437	response regulator, receiver
IFE08_RS09110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IFE08_RS09115	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IFE08_RS09120	COG2204	response regulator
IFE08_RS09175	COG0731	radical SAM domain protein
IFE08_RS09195	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IFE08_RS09200	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
IFE08_RS09205	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IFE08_RS09225	COG1053	succinate dehydrogenase
IFE08_RS09260	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IFE08_RS09265	COG3118	belongs to the thioredoxin family
IFE08_RS09270	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IFE08_RS09290	COG0492	ferredoxin-NADP+ reductase activity
IFE08_RS09305	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IFE08_RS09320	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IFE08_RS09325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IFE08_RS09330	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IFE08_RS09355	COG3706	GGDEF domain
IFE08_RS09370	COG0653	protein targeting
IFE08_RS09380	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IFE08_RS09410	COG0193	aminoacyl-tRNA hydrolase activity
IFE08_RS09415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IFE08_RS09420	COG0740	serine-type endopeptidase activity
IFE08_RS09460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IFE08_RS09465	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IFE08_RS09470	COG1477	protein flavinylation
IFE08_RS09475	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IFE08_RS09520	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IFE08_RS09520	COG0493	'glutamate synthase
IFE08_RS09530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IFE08_RS09535	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IFE08_RS09550	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IFE08_RS09570	COG0459	protein refolding
IFE08_RS09580	COG5341	Protein conserved in bacteria
IFE08_RS09585	COG0577	efflux transmembrane transporter activity
IFE08_RS09585	COG1136	(ABC) transporter
IFE08_RS09590	COG0826	peptidase U32
IFE08_RS09600	COG1132	(ABC) transporter
IFE08_RS09635	COG1122	ATPase activity
IFE08_RS09650	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IFE08_RS09655	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IFE08_RS09670	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IFE08_RS09705	COG1131	(ABC) transporter
IFE08_RS09710	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IFE08_RS09715	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IFE08_RS09720	COG1862	Preprotein translocase
IFE08_RS09725	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IFE08_RS09730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IFE08_RS09735	COG0571	ribonuclease III activity
IFE08_RS09740	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IFE08_RS09745	COG1573	uracil-dna glycosylase
IFE08_RS09760	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IFE08_RS09765	COG0563	adenylate kinase activity
IFE08_RS09785	COG0739	heme binding
IFE08_RS09825	COG0556	nucleotide-excision repair
IFE08_RS09830	COG0254	rRNA binding
IFE08_RS09870	COG2217	Heavy metal translocating P-type atpase
IFE08_RS09875	COG0640	Transcriptional regulator
IFE08_RS09895	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
IFE08_RS09900	COG0784	Response regulator, receiver
IFE08_RS09900	COG3437	response regulator, receiver
IFE08_RS09905	COG1921	L-seryl-tRNASec selenium transferase activity
IFE08_RS09910	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IFE08_RS09920	COG2003	Belongs to the UPF0758 family
IFE08_RS09925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IFE08_RS09940	COG1132	(ABC) transporter
IFE08_RS09945	COG0457	Tetratricopeptide repeat
IFE08_RS09975	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IFE08_RS09995	COG1132	(ABC) transporter
IFE08_RS10115	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
IFE08_RS10190	COG0564	pseudouridine synthase activity
IFE08_RS10205	COG4656	Part of a membrane complex involved in electron transport
IFE08_RS10250	COG1175	transmembrane transport
IFE08_RS10255	COG3833	ABC-type maltose transport systems, permease component
IFE08_RS10260	COG3842	ATPase activity
IFE08_RS10265	COG1640	4-alpha-glucanotransferase
IFE08_RS10280	COG0779	Required for maturation of 30S ribosomal subunits
IFE08_RS10290	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IFE08_RS10295	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IFE08_RS10300	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IFE08_RS10320	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IFE08_RS10325	COG0049	tRNA binding
IFE08_RS10330	COG0791	NLP P60 protein
IFE08_RS10335	COG0318	PFAM AMP-dependent synthetase and ligase
IFE08_RS10355	COG2274	protein secretion by the type I secretion system
IFE08_RS10405	COG1609	Transcriptional regulator
IFE08_RS10420	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IFE08_RS10430	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IFE08_RS10435	COG0300	oxidoreductase activity
IFE08_RS10445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IFE08_RS10465	COG1704	LemA family
IFE08_RS10470	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IFE08_RS10475	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IFE08_RS10485	COG0482	sulfurtransferase activity
IFE08_RS10535	COG4608	Belongs to the ABC transporter superfamily
IFE08_RS10540	COG0444	Belongs to the ABC transporter superfamily
IFE08_RS10545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IFE08_RS10550	COG0601	transmembrane transport
IFE08_RS10560	COG1505	serine-type exopeptidase activity
IFE08_RS10565	COG4166	transmembrane transport
IFE08_RS10575	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IFE08_RS10600	COG0617	tRNA 3'-terminal CCA addition
IFE08_RS10625	COG1078	dGTPase activity
IFE08_RS10635	COG0047	phosphoribosylformylglycinamidine synthase activity
IFE08_RS10640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IFE08_RS10645	COG0569	domain protein
IFE08_RS10670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IFE08_RS10675	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IFE08_RS10680	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IFE08_RS10690	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IFE08_RS10695	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IFE08_RS10705	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
IFE08_RS10710	COG1671	Belongs to the UPF0178 family
IFE08_RS10725	COG0444	Belongs to the ABC transporter superfamily
IFE08_RS10730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IFE08_RS10735	COG0601	transmembrane transport
IFE08_RS10740	COG0747	negative chemotaxis
IFE08_RS10750	COG0840	transmembrane signaling receptor activity
IFE08_RS10780	COG0335	large ribosomal subunit rRNA binding
IFE08_RS10785	COG0336	Belongs to the RNA methyltransferase TrmD family
IFE08_RS10790	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IFE08_RS10795	COG1837	Belongs to the UPF0109 family
IFE08_RS10800	COG0228	four-way junction DNA binding
IFE08_RS10805	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IFE08_RS10835	COG1309	transcriptional regulator
IFE08_RS10845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IFE08_RS10850	COG1285	pathogenesis
IFE08_RS10880	COG1131	(ABC) transporter
IFE08_RS10885	COG4953	penicillin-binding protein 1C
IFE08_RS10895	COG4953	penicillin-binding protein 1C
IFE08_RS10900	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IFE08_RS10915	COG0084	hydrolase, TatD family'
IFE08_RS10925	COG0709	Synthesizes selenophosphate from selenide and ATP
IFE08_RS10940	COG1286	toxin biosynthetic process
IFE08_RS10945	COG0470	DNA polymerase III
IFE08_RS10950	COG5002	protein histidine kinase activity
IFE08_RS10955	COG0450	alkyl hydroperoxide reductase
IFE08_RS10960	COG0708	Exodeoxyribonuclease III
IFE08_RS10965	COG0024	Methionine aminopeptidase
IFE08_RS10970	COG0484	heat shock protein binding
IFE08_RS11045	COG4211	Belongs to the binding-protein-dependent transport system permease family
IFE08_RS11050	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IFE08_RS11065	COG1162	GTPase activity
IFE08_RS11080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IFE08_RS11095	COG1132	(ABC) transporter
IFE08_RS11105	COG0203	ribosomal protein L17
IFE08_RS11110	COG0202	RNA polymerase activity
IFE08_RS11115	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IFE08_RS11120	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IFE08_RS11125	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IFE08_RS11135	COG0200	Binds to the 23S rRNA
IFE08_RS11140	COG1841	ribosomal large subunit assembly
IFE08_RS11145	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IFE08_RS11150	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IFE08_RS11155	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IFE08_RS11160	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IFE08_RS11165	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IFE08_RS11170	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IFE08_RS11175	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IFE08_RS11180	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IFE08_RS11185	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IFE08_RS11190	COG0255	Belongs to the universal ribosomal protein uL29 family
IFE08_RS11195	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IFE08_RS11200	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IFE08_RS11205	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IFE08_RS11210	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IFE08_RS11215	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IFE08_RS11220	COG0089	rRNA binding
IFE08_RS11225	COG0088	Forms part of the polypeptide exit tunnel
IFE08_RS11230	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IFE08_RS11235	COG0051	transcription antitermination factor activity, RNA binding
IFE08_RS11240	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IFE08_RS11245	COG0714	Associated with various cellular activities
IFE08_RS11250	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
IFE08_RS11280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IFE08_RS11295	COG0840	transmembrane signaling receptor activity
IFE08_RS11310	COG0657	acetylesterase activity
IFE08_RS11335	COG0488	(ABC) transporter
IFE08_RS11355	COG0446	pyridine nucleotide-disulphide oxidoreductase
IFE08_RS11395	COG1132	(ABC) transporter
IFE08_RS11395	COG2375	cellular response to nickel ion
IFE08_RS11400	COG1132	(ABC) transporter
IFE08_RS11415	COG1129	ABC transporter
IFE08_RS11425	COG1309	transcriptional regulator
IFE08_RS11430	COG3848	Pyruvate phosphate dikinase
IFE08_RS11430	COG0574	Belongs to the PEP-utilizing enzyme family
IFE08_RS11460	COG3708	Transcriptional regulator
IFE08_RS11460	COG2207	Transcriptional regulator
IFE08_RS11465	COG2378	regulation of single-species biofilm formation
IFE08_RS11480	COG3708	Transcriptional regulator
IFE08_RS11480	COG2207	Transcriptional regulator
IFE08_RS11485	COG1053	succinate dehydrogenase
IFE08_RS11485	COG3976	FMN-binding domain protein
IFE08_RS11490	COG1120	ATPase activity
IFE08_RS11495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IFE08_RS11500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IFE08_RS11505	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IFE08_RS11520	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IFE08_RS11550	COG1067	ATP-dependent peptidase activity
IFE08_RS11560	COG2199	diguanylate cyclase activity
IFE08_RS11580	COG0205	6-phosphofructokinase activity
IFE08_RS11585	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IFE08_RS11590	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IFE08_RS11595	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IFE08_RS11610	COG0149	triose-phosphate isomerase activity
IFE08_RS11615	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IFE08_RS11620	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IFE08_RS11630	COG0534	Mate efflux family protein
IFE08_RS11635	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IFE08_RS11645	COG0588	phosphoglycerate mutase activity
IFE08_RS11665	COG0305	Participates in initiation and elongation during chromosome replication
IFE08_RS11680	COG1193	negative regulation of DNA recombination
IFE08_RS11695	COG2304	oxidoreductase activity
IFE08_RS11720	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IFE08_RS11740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IFE08_RS11745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IFE08_RS11750	COG1121	(ABC) transporter
IFE08_RS11755	COG0803	Belongs to the bacterial solute-binding protein 9 family
IFE08_RS11775	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IFE08_RS11795	COG0205	6-phosphofructokinase activity
IFE08_RS11815	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IFE08_RS11825	COG1847	R3H domain protein
IFE08_RS11830	COG0706	membrane insertase activity
IFE08_RS11835	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IFE08_RS11840	COG0594	ribonuclease P activity
IFE08_RS11845	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IFE08_RS11870	COG2274	protein secretion by the type I secretion system
IFE08_RS11875	COG3314	Sporulation integral membrane protein YlbJ
IFE08_RS11880	COG0813	purine-nucleoside phosphorylase activity
IFE08_RS11910	COG3706	GGDEF domain
IFE08_RS11940	COG1234	tRNA 3'-trailer cleavage
IFE08_RS11955	COG3951	Flagellar rod assembly protein muramidase FlgJ
IFE08_RS11960	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IFE08_RS12005	COG3842	ATPase activity
IFE08_RS12010	COG0514	ATP-dependent DNA helicase (RecQ)
IFE08_RS12015	COG0187	DNA topoisomerase II activity
IFE08_RS12020	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IFE08_RS12030	COG2235	arginine
IFE08_RS12035	COG0017	Asparaginyl-tRNA synthetase
IFE08_RS12040	COG1686	Belongs to the peptidase S11 family
IFE08_RS12055	COG0840	transmembrane signaling receptor activity
IFE08_RS12080	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IFE08_RS12110	COG0728	peptidoglycan biosynthetic process
IFE08_RS12115	COG0786	glutamate:sodium symporter activity
IFE08_RS12135	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IFE08_RS12160	COG2885	chlorophyll binding
IFE08_RS12170	COG0840	transmembrane signaling receptor activity
IFE08_RS12175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IFE08_RS12185	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IFE08_RS12190	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IFE08_RS12205	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IFE08_RS12205	COG0574	Belongs to the PEP-utilizing enzyme family
IFE08_RS12220	COG2304	oxidoreductase activity
IFE08_RS12230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IFE08_RS12240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IFE08_RS12245	COG1120	ATPase activity
IFE08_RS12285	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IFE08_RS12295	COG1104	cysteine desulfurase activity
IFE08_RS12300	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IFE08_RS12305	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IFE08_RS12310	COG4536	flavin adenine dinucleotide binding
IFE08_RS12315	COG1253	flavin adenine dinucleotide binding
IFE08_RS12325	COG4166	transmembrane transport
IFE08_RS12330	COG4608	Belongs to the ABC transporter superfamily
IFE08_RS12335	COG0444	Belongs to the ABC transporter superfamily
IFE08_RS12340	COG0747	negative chemotaxis
IFE08_RS12345	COG0747	negative chemotaxis
IFE08_RS12350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IFE08_RS12355	COG4174	ABC transporter (Permease)
IFE08_RS12385	COG2203	Gaf domain
IFE08_RS12385	COG2199	diguanylate cyclase activity
IFE08_RS12410	COG0800	Aldolase
IFE08_RS12485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IFE08_RS12495	COG0328	RNA-DNA hybrid ribonuclease activity
IFE08_RS12500	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IFE08_RS12505	COG0301	tRNA thio-modification
IFE08_RS12515	COG1131	(ABC) transporter
IFE08_RS12535	COG0326	Molecular chaperone. Has ATPase activity
IFE08_RS12550	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IFE08_RS12555	COG1509	lysine 2,3-aminomutase activity
IFE08_RS12570	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IFE08_RS12605	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IFE08_RS12610	COG0840	transmembrane signaling receptor activity
IFE08_RS12625	COG0084	hydrolase, TatD family'
IFE08_RS12630	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IFE08_RS12630	COG3116	cell division
IFE08_RS12645	COG0716	FMN binding
IFE08_RS12660	COG0493	'glutamate synthase
IFE08_RS12675	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IFE08_RS12680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IFE08_RS12685	COG1419	protein localization to endoplasmic reticulum
IFE08_RS12700	COG1191	sigma factor activity
IFE08_RS12730	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IFE08_RS12735	COG0628	permease
IFE08_RS12740	COG0363	glucosamine-6-phosphate deaminase activity
IFE08_RS12755	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IFE08_RS12765	COG0584	glycerophosphoryl diester phosphodiesterase
IFE08_RS12770	COG1040	competence protein
IFE08_RS12775	COG0018	arginyl-trna synthetase
IFE08_RS12780	COG0714	Associated with various cellular activities
IFE08_RS12835	COG0534	Mate efflux family protein
IFE08_RS12840	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IFE08_RS12845	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IFE08_RS12855	COG1338	Plays a role in the flagellum-specific transport system
IFE08_RS12865	COG1776	CheC inhibitor of MCP methylation
IFE08_RS12865	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IFE08_RS12870	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IFE08_RS12875	COG1580	Controls the rotational direction of flagella during chemotaxis
IFE08_RS12880	COG1360	Flagellar Motor Protein
IFE08_RS12885	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IFE08_RS12900	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IFE08_RS12940	COG3152	Membrane
IFE08_RS12955	COG2887	Belongs to the helicase family. UvrD subfamily
IFE08_RS12960	COG1074	ATP-dependent DNA helicase activity
IFE08_RS12970	COG1121	(ABC) transporter
IFE08_RS12975	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IFE08_RS13020	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IFE08_RS13030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IFE08_RS13030	COG1747	RNA polymerase binding
IFE08_RS13050	COG0116	Belongs to the methyltransferase superfamily
IFE08_RS13100	COG1121	(ABC) transporter
IFE08_RS13135	COG0456	acetyltransferase
IFE08_RS13160	COG3093	addiction module antidote protein HigA
IFE08_RS13215	COG0737	Belongs to the 5'-nucleotidase family
IFE08_RS13225	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IFE08_RS13230	COG0166	Belongs to the GPI family
IFE08_RS13235	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IFE08_RS13245	COG0318	PFAM AMP-dependent synthetase and ligase
IFE08_RS13285	COG1473	amidohydrolase
IFE08_RS13305	COG4555	ABC transporter
IFE08_RS13335	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IFE08_RS13360	COG1132	(ABC) transporter
IFE08_RS13365	COG1132	(ABC) transporter
IFE08_RS13365	COG2375	cellular response to nickel ion
IFE08_RS13375	COG1129	ABC transporter
IFE08_RS13385	COG2207	Transcriptional regulator
IFE08_RS13405	COG2184	nucleotidyltransferase activity
IFE08_RS13420	COG5002	protein histidine kinase activity
IFE08_RS13440	COG2357	RelA SpoT domain protein
IFE08_RS13460	COG1132	(ABC) transporter
IFE08_RS13475	COG2226	methyltransferase
IFE08_RS13480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IFE08_RS13485	COG1120	ATPase activity
IFE08_RS13495	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IFE08_RS13505	COG1132	(ABC) transporter
IFE08_RS13550	COG0840	transmembrane signaling receptor activity
IFE08_RS13555	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IFE08_RS13565	COG1516	flagellar protein fliS
IFE08_RS13570	COG1983	PspC domain protein
IFE08_RS13585	COG3735	TraB family
IFE08_RS13595	COG4115	mRNA cleavage
IFE08_RS13615	COG3588	fructose-bisphosphate aldolase
IFE08_RS13620	COG0601	transmembrane transport
IFE08_RS13625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IFE08_RS13630	COG0444	Belongs to the ABC transporter superfamily
IFE08_RS13635	COG4608	Belongs to the ABC transporter superfamily
IFE08_RS13640	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IFE08_RS13645	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IFE08_RS13655	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IFE08_RS13670	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IFE08_RS13680	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
IFE08_RS13685	COG0351	phosphomethylpyrimidine kinase
IFE08_RS13690	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IFE08_RS13700	COG1505	serine-type exopeptidase activity
IFE08_RS13705	COG1528	Iron-storage protein
IFE08_RS13710	COG0477	Major facilitator Superfamily
IFE08_RS13715	COG1473	amidohydrolase
IFE08_RS13725	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IFE08_RS13735	COG1362	aminopeptidase activity
IFE08_RS13740	COG0445	tRNA wobble uridine modification
IFE08_RS13745	COG1492	cobalamin metabolic process
IFE08_RS13755	COG1968	undecaprenyl-diphosphatase activity
IFE08_RS13760	COG1674	ftsk spoiiie
IFE08_RS13765	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IFE08_RS13770	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
IFE08_RS13770	COG0540	Belongs to the ATCase OTCase family
IFE08_RS13775	COG4172	Belongs to the ABC transporter superfamily
IFE08_RS13785	COG1132	(ABC) transporter
IFE08_RS13790	COG0674	pyruvate-flavodoxin oxidoreductase activity
IFE08_RS13790	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IFE08_RS13790	COG1013	pyruvate-flavodoxin oxidoreductase activity
IFE08_RS13790	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IFE08_RS13795	COG0840	transmembrane signaling receptor activity
IFE08_RS13805	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
IFE08_RS13820	COG1774	PSP1 C-terminal conserved region
IFE08_RS13825	COG1728	Protein conserved in bacteria
IFE08_RS13835	COG0739	heme binding
IFE08_RS13840	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IFE08_RS13850	COG1131	(ABC) transporter
IFE08_RS13865	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IFE08_RS13875	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IFE08_RS13905	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IFE08_RS13910	COG0592	DNA-directed DNA polymerase activity
IFE08_RS13915	COG2116	formate transmembrane transporter activity