locus-tag	class	description
TPE_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TPE_RS00010	COG2235	arginine
TPE_RS00015	COG0017	Asparaginyl-tRNA synthetase
TPE_RS00020	COG1686	Belongs to the peptidase S11 family
TPE_RS00035	COG0840	transmembrane signaling receptor activity
TPE_RS00060	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TPE_RS00090	COG0728	peptidoglycan biosynthetic process
TPE_RS00095	COG0786	glutamate:sodium symporter activity
TPE_RS00115	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TPE_RS00145	COG2885	chlorophyll binding
TPE_RS00150	COG0840	transmembrane signaling receptor activity
TPE_RS00155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TPE_RS00165	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TPE_RS00170	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TPE_RS00185	COG0574	Belongs to the PEP-utilizing enzyme family
TPE_RS00185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TPE_RS00200	COG2304	oxidoreductase activity
TPE_RS00210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TPE_RS00220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPE_RS00225	COG1120	ATPase activity
TPE_RS00250	COG4750	Nucleotidyl transferase
TPE_RS00275	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TPE_RS00280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPE_RS00290	COG0588	phosphoglycerate mutase activity
TPE_RS00305	COG2033	superoxide reductase activity
TPE_RS00315	COG0534	Mate efflux family protein
TPE_RS00615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TPE_RS00620	COG0601	transmembrane transport
TPE_RS00625	COG0747	negative chemotaxis
TPE_RS00630	COG4977	sequence-specific DNA binding
TPE_RS00630	COG1917	Cupin 2, conserved barrel domain protein
TPE_RS00680	COG0455	bacterial-type flagellum organization
TPE_RS00690	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TPE_RS00695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TPE_RS00695	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TPE_RS00720	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TPE_RS00735	COG3949	Membrane
TPE_RS00755	COG0840	transmembrane signaling receptor activity
TPE_RS00760	COG0542	response to heat
TPE_RS00765	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TPE_RS00785	COG0768	penicillin binding
TPE_RS00795	COG2604	Protein of unknown function DUF115
TPE_RS00810	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TPE_RS00825	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TPE_RS00830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TPE_RS00835	COG0037	tRNA processing
TPE_RS00840	COG0457	Tetratricopeptide repeat
TPE_RS00845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TPE_RS00850	COG1073	alpha beta
TPE_RS00875	COG1373	ATPase (AAA superfamily
TPE_RS00890	COG1086	Polysaccharide biosynthesis protein
TPE_RS00895	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TPE_RS00915	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TPE_RS00920	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TPE_RS00940	COG2089	acid synthase
TPE_RS00945	COG1083	cytidylyl-transferase
TPE_RS00950	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TPE_RS00995	COG3475	LICD family
TPE_RS01040	COG1760	l-serine dehydratase
TPE_RS01045	COG1760	l-serine dehydratase
TPE_RS01050	COG1114	Component of the transport system for branched-chain amino acids
TPE_RS01065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TPE_RS01130	COG1570	exodeoxyribonuclease VII activity
TPE_RS01140	COG1129	ABC transporter
TPE_RS01145	COG3493	citrate carrier protein
TPE_RS01150	COG1879	ABC-type sugar transport system periplasmic component
TPE_RS01155	COG1840	ABC-type Fe3 transport system, periplasmic component
TPE_RS01160	COG0438	transferase activity, transferring glycosyl groups
TPE_RS01165	COG3842	ATPase activity
TPE_RS01175	COG0148	phosphopyruvate hydratase activity
TPE_RS01185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TPE_RS01190	COG1116	anion transmembrane transporter activity
TPE_RS01235	COG0569	domain protein
TPE_RS01240	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TPE_RS01245	COG0504	CTP synthase activity
TPE_RS01255	COG0574	Belongs to the PEP-utilizing enzyme family
TPE_RS01255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TPE_RS01280	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TPE_RS01295	COG0840	transmembrane signaling receptor activity
TPE_RS01345	COG1120	ATPase activity
TPE_RS01350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPE_RS01400	COG3177	Filamentation induced by cAMP protein fic
TPE_RS01415	COG4208	sulfate ABC transporter
TPE_RS01430	COG0726	polysaccharide deacetylase
TPE_RS01440	COG1122	ATPase activity
TPE_RS01445	COG1268	BioY protein
TPE_RS01455	COG1652	LysM domain
TPE_RS01460	COG0517	IMP dehydrogenase activity
TPE_RS01460	COG0516	GMP reductase activity
TPE_RS01475	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TPE_RS01505	COG0569	domain protein
TPE_RS01510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TPE_RS01540	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TPE_RS01555	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TPE_RS01575	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TPE_RS01585	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TPE_RS01600	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TPE_RS01610	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TPE_RS01645	COG2226	methyltransferase
TPE_RS01675	COG4555	ABC transporter
TPE_RS01695	COG1132	(ABC) transporter
TPE_RS01700	COG1132	(ABC) transporter
TPE_RS01710	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TPE_RS01715	COG3876	Protein conserved in bacteria
TPE_RS01720	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TPE_RS01745	COG1122	ATPase activity
TPE_RS01765	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TPE_RS01765	COG1918	ferrous iron import across plasma membrane
TPE_RS01830	COG0737	Belongs to the 5'-nucleotidase family
TPE_RS01845	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TPE_RS01855	COG0632	four-way junction helicase activity
TPE_RS01860	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TPE_RS01875	COG0519	Catalyzes the synthesis of GMP from XMP
TPE_RS01900	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TPE_RS01905	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TPE_RS01920	COG1136	(ABC) transporter
TPE_RS01920	COG0577	efflux transmembrane transporter activity
TPE_RS01925	COG0577	efflux transmembrane transporter activity
TPE_RS01925	COG1136	(ABC) transporter
TPE_RS01930	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
TPE_RS01935	COG2217	Heavy metal translocating P-type atpase
TPE_RS01940	COG0525	valine-tRNA ligase activity
TPE_RS01945	COG1132	(ABC) transporter
TPE_RS01960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TPE_RS01970	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TPE_RS01980	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TPE_RS01985	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TPE_RS01990	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TPE_RS02010	COG1924	4 iron, 4 sulfur cluster binding
TPE_RS02015	COG0840	transmembrane signaling receptor activity
TPE_RS02055	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TPE_RS02065	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TPE_RS02070	COG0250	Participates in transcription elongation, termination and antitermination
TPE_RS02075	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TPE_RS02080	COG0081	regulation of translation
TPE_RS02085	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TPE_RS02090	COG0222	ribosome binding
TPE_RS02095	COG0085	RNA polymerase activity
TPE_RS02100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TPE_RS02115	COG0322	excinuclease ABC activity
TPE_RS02135	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TPE_RS02155	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TPE_RS02160	COG4585	Histidine kinase
TPE_RS02175	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TPE_RS02185	COG1363	Peptidase, m42
TPE_RS02200	COG1022	Amp-dependent synthetase and ligase
TPE_RS02210	COG1309	transcriptional regulator
TPE_RS02215	COG0786	glutamate:sodium symporter activity
TPE_RS02220	COG1132	(ABC) transporter
TPE_RS02235	COG1129	ABC transporter
TPE_RS02245	COG1132	(ABC) transporter
TPE_RS02260	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TPE_RS02265	COG1394	ATPase activity, coupled to movement of substances
TPE_RS02280	COG1692	metallophosphoesterase
TPE_RS02290	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TPE_RS02295	COG1104	cysteine desulfurase activity
TPE_RS02300	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TPE_RS02305	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TPE_RS02310	COG4536	flavin adenine dinucleotide binding
TPE_RS02315	COG1253	flavin adenine dinucleotide binding
TPE_RS02325	COG4166	transmembrane transport
TPE_RS02330	COG4608	Belongs to the ABC transporter superfamily
TPE_RS02335	COG0444	Belongs to the ABC transporter superfamily
TPE_RS02340	COG4166	transmembrane transport
TPE_RS02345	COG0747	negative chemotaxis
TPE_RS02350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TPE_RS02355	COG4174	ABC transporter (Permease)
TPE_RS02390	COG2203	Gaf domain
TPE_RS02390	COG2199	diguanylate cyclase activity
TPE_RS02480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TPE_RS02490	COG0328	RNA-DNA hybrid ribonuclease activity
TPE_RS02495	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TPE_RS02500	COG0301	tRNA thio-modification
TPE_RS02510	COG1131	(ABC) transporter
TPE_RS02525	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TPE_RS02530	COG0326	Molecular chaperone. Has ATPase activity
TPE_RS02545	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TPE_RS02550	COG1509	lysine 2,3-aminomutase activity
TPE_RS02565	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TPE_RS02600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TPE_RS02605	COG0840	transmembrane signaling receptor activity
TPE_RS02620	COG0084	hydrolase, TatD family'
TPE_RS02625	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TPE_RS02625	COG3116	cell division
TPE_RS02640	COG0716	FMN binding
TPE_RS02655	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TPE_RS02660	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TPE_RS02665	COG1419	protein localization to endoplasmic reticulum
TPE_RS02680	COG1191	sigma factor activity
TPE_RS02710	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TPE_RS02715	COG0628	permease
TPE_RS02720	COG0363	glucosamine-6-phosphate deaminase activity
TPE_RS02735	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TPE_RS02745	COG0584	glycerophosphoryl diester phosphodiesterase
TPE_RS02750	COG1040	competence protein
TPE_RS02755	COG0018	arginyl-trna synthetase
TPE_RS02760	COG0714	Associated with various cellular activities
TPE_RS02810	COG0534	Mate efflux family protein
TPE_RS02815	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
TPE_RS02820	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TPE_RS02830	COG1338	Plays a role in the flagellum-specific transport system
TPE_RS02840	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TPE_RS02840	COG1776	CheC inhibitor of MCP methylation
TPE_RS02845	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TPE_RS02850	COG1580	Controls the rotational direction of flagella during chemotaxis
TPE_RS02855	COG1360	Flagellar Motor Protein
TPE_RS02860	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TPE_RS02875	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TPE_RS02915	COG3152	Membrane
TPE_RS02925	COG2887	Belongs to the helicase family. UvrD subfamily
TPE_RS02930	COG1074	ATP-dependent DNA helicase activity
TPE_RS02940	COG1121	(ABC) transporter
TPE_RS02945	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TPE_RS02970	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TPE_RS02980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TPE_RS02980	COG1747	RNA polymerase binding
TPE_RS03000	COG0116	Belongs to the methyltransferase superfamily
TPE_RS03090	COG1121	(ABC) transporter
TPE_RS03105	COG3541	Predicted nucleotidyltransferase
TPE_RS03125	COG0737	Belongs to the 5'-nucleotidase family
TPE_RS03135	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TPE_RS03140	COG0166	Belongs to the GPI family
TPE_RS03145	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TPE_RS03155	COG0318	PFAM AMP-dependent synthetase and ligase
TPE_RS03190	COG1473	amidohydrolase
TPE_RS03210	COG4555	ABC transporter
TPE_RS03235	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TPE_RS03265	COG1132	(ABC) transporter
TPE_RS03270	COG2375	cellular response to nickel ion
TPE_RS03270	COG1132	(ABC) transporter
TPE_RS03280	COG1129	ABC transporter
TPE_RS03290	COG2207	Transcriptional regulator
TPE_RS03315	COG2357	RelA SpoT domain protein
TPE_RS03320	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TPE_RS03340	COG1755	Isoprenylcysteine carboxyl methyltransferase
TPE_RS03355	COG2239	Acts as a magnesium transporter
TPE_RS03375	COG0556	nucleotide-excision repair
TPE_RS03400	COG4946	Tricorn protease homolog
TPE_RS03400	COG1506	peptidase
TPE_RS03400	COG0823	Involved in the tonB-independent uptake of proteins
TPE_RS03410	COG1228	amidohydrolase
TPE_RS03420	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TPE_RS03435	COG0423	glycine-tRNA ligase activity
TPE_RS03455	COG1472	Belongs to the glycosyl hydrolase 3 family
TPE_RS03475	COG1876	peptidase activity
TPE_RS03480	COG1366	Belongs to the anti-sigma-factor antagonist family
TPE_RS03505	COG1393	Belongs to the ArsC family
TPE_RS03510	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TPE_RS03520	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TPE_RS03525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TPE_RS03530	COG1115	amino acid carrier protein
TPE_RS03535	COG1254	Belongs to the acylphosphatase family
TPE_RS03565	COG1301	dicarboxylic acid transport
TPE_RS03570	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TPE_RS03575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TPE_RS03580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TPE_RS03585	COG1690	Belongs to the RtcB family
TPE_RS03590	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TPE_RS03595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TPE_RS03595	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TPE_RS03600	COG0095	Lipoate-protein ligase
TPE_RS03605	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TPE_RS03610	COG1305	Transglutaminase-like
TPE_RS03625	COG0215	cysteine-tRNA ligase activity
TPE_RS03635	COG0330	HflC and HflK could
TPE_RS03640	COG2116	formate transmembrane transporter activity
TPE_RS03645	COG0592	DNA-directed DNA polymerase activity
TPE_RS03650	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TPE_RS03680	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TPE_RS03690	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TPE_RS03705	COG1131	(ABC) transporter
TPE_RS03715	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TPE_RS03720	COG0739	heme binding
TPE_RS03730	COG1728	Protein conserved in bacteria
TPE_RS03735	COG1774	PSP1 C-terminal conserved region
TPE_RS03750	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
TPE_RS03760	COG0840	transmembrane signaling receptor activity
TPE_RS03765	COG0674	pyruvate-flavodoxin oxidoreductase activity
TPE_RS03765	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TPE_RS03765	COG1013	pyruvate-flavodoxin oxidoreductase activity
TPE_RS03765	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TPE_RS03770	COG1132	(ABC) transporter
TPE_RS03780	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
TPE_RS03780	COG0540	Belongs to the ATCase OTCase family
TPE_RS03785	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TPE_RS03790	COG1674	ftsk spoiiie
TPE_RS03795	COG1968	undecaprenyl-diphosphatase activity
TPE_RS03805	COG1492	cobalamin metabolic process
TPE_RS03810	COG0445	tRNA wobble uridine modification
TPE_RS03815	COG1362	aminopeptidase activity
TPE_RS03825	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TPE_RS03830	COG1528	Iron-storage protein
TPE_RS03835	COG1505	serine-type exopeptidase activity
TPE_RS03845	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TPE_RS03850	COG0351	phosphomethylpyrimidine kinase
TPE_RS03855	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
TPE_RS03865	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TPE_RS03880	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TPE_RS03890	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TPE_RS03895	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TPE_RS03910	COG4608	Belongs to the ABC transporter superfamily
TPE_RS03915	COG0444	Belongs to the ABC transporter superfamily
TPE_RS03920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TPE_RS03925	COG0601	transmembrane transport
TPE_RS03930	COG3588	fructose-bisphosphate aldolase
TPE_RS03945	COG4115	mRNA cleavage
TPE_RS03955	COG4115	mRNA cleavage
TPE_RS03965	COG3735	TraB family
TPE_RS03980	COG1983	PspC domain protein
TPE_RS03985	COG1516	flagellar protein fliS
TPE_RS03995	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TPE_RS04000	COG0840	transmembrane signaling receptor activity
TPE_RS04025	COG1132	(ABC) transporter
TPE_RS04045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TPE_RS04055	COG1120	ATPase activity
TPE_RS04060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPE_RS04065	COG2226	methyltransferase
TPE_RS04115	COG1132	(ABC) transporter
TPE_RS04155	COG0167	dihydroorotate dehydrogenase activity
TPE_RS04160	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TPE_RS04170	COG0701	Predicted permease
TPE_RS04180	COG0587	DNA-directed DNA polymerase activity
TPE_RS04185	COG1028	Short-chain dehydrogenase reductase Sdr
TPE_RS04190	COG0840	transmembrane signaling receptor activity
TPE_RS04195	COG0446	pyridine nucleotide-disulphide oxidoreductase
TPE_RS04200	COG4555	ABC transporter
TPE_RS04225	COG0730	response to heat
TPE_RS04235	COG1959	2 iron, 2 sulfur cluster binding
TPE_RS04240	COG2910	NAD(P)H-binding
TPE_RS04245	COG2089	acid synthase
TPE_RS04260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TPE_RS04280	COG1120	ATPase activity
TPE_RS04320	COG1696	Membrane protein involved in D-alanine export
TPE_RS04325	COG3842	ATPase activity
TPE_RS04330	COG0783	Belongs to the Dps family
TPE_RS04335	COG0840	transmembrane signaling receptor activity
TPE_RS04355	COG0425	Belongs to the sulfur carrier protein TusA family
TPE_RS04365	COG0709	Synthesizes selenophosphate from selenide and ATP
TPE_RS04380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TPE_RS04395	COG1136	(ABC) transporter
TPE_RS04400	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
TPE_RS04415	COG0629	single-stranded DNA binding
TPE_RS04420	COG1691	(AIR) carboxylase
TPE_RS04445	COG0601	transmembrane transport
TPE_RS04450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TPE_RS04455	COG0444	Belongs to the ABC transporter superfamily
TPE_RS04460	COG4172	Belongs to the ABC transporter superfamily
TPE_RS04465	COG1132	(ABC) transporter
TPE_RS04470	COG1132	(ABC) transporter
TPE_RS04495	COG1185	polyribonucleotide nucleotidyltransferase activity
TPE_RS04500	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TPE_RS04505	COG0196	riboflavin kinase activity
TPE_RS04510	COG0840	transmembrane signaling receptor activity
TPE_RS04535	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TPE_RS04550	COG2233	PERMEase
TPE_RS04560	COG0671	phosphoesterase, PA-phosphatase related
TPE_RS04565	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TPE_RS04590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TPE_RS04615	COG0546	phosphoglycolate phosphatase activity
TPE_RS04620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TPE_RS04625	COG4166	transmembrane transport
TPE_RS04780	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TPE_RS04785	COG0826	peptidase U32
TPE_RS04790	COG1606	tRNA processing
TPE_RS04795	COG1132	(ABC) transporter
TPE_RS04805	COG1132	(ABC) transporter
TPE_RS04825	COG1475	DNA binding
TPE_RS04830	COG1192	Involved in chromosome partitioning
TPE_RS04835	COG0840	transmembrane signaling receptor activity
TPE_RS04845	COG1802	Transcriptional regulator
TPE_RS04865	COG0511	ligase activity, forming carbon-carbon bonds
TPE_RS04870	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TPE_RS04880	COG2301	Belongs to the HpcH HpaI aldolase family
TPE_RS04885	COG3051	citrate lyase alpha subunit
TPE_RS04900	COG0616	signal peptide processing
TPE_RS04905	COG0012	GTP binding
TPE_RS04920	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TPE_RS04925	COG1744	ABC transporter substrate-binding protein PnrA-like
TPE_RS04930	COG3845	ABC transporter
TPE_RS04935	COG4603	Belongs to the binding-protein-dependent transport system permease family
TPE_RS04940	COG1079	Belongs to the binding-protein-dependent transport system permease family
TPE_RS04950	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TPE_RS04985	COG0280	phosphate acetyltransferase
TPE_RS04990	COG0457	Tetratricopeptide repeat
TPE_RS05000	COG0542	response to heat
TPE_RS05005	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TPE_RS05015	COG0101	tRNA pseudouridine synthase activity
TPE_RS05025	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TPE_RS05035	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TPE_RS05045	COG0840	transmembrane signaling receptor activity
TPE_RS05050	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TPE_RS05055	COG0740	serine-type endopeptidase activity
TPE_RS05060	COG0544	peptidyl-prolyl cis-trans isomerase activity
TPE_RS05075	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TPE_RS05080	COG2211	Major facilitator Superfamily
TPE_RS05090	COG2201	protein-glutamate methylesterase activity
TPE_RS05100	COG0835	chemotaxis
TPE_RS05105	COG0643	Histidine kinase
TPE_RS05105	COG2198	Histidine kinase
TPE_RS05120	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TPE_RS05135	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TPE_RS05135	COG0316	Belongs to the HesB IscA family
TPE_RS05140	COG0756	dUTP diphosphatase activity
TPE_RS05145	COG3330	Domain of unknown function (DUF4912)
TPE_RS05160	COG0543	2 iron, 2 sulfur cluster binding
TPE_RS05175	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TPE_RS05185	COG2080	2 iron, 2 sulfur cluster binding
TPE_RS05200	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TPE_RS05205	COG1987	bacterial-type flagellum assembly
TPE_RS05210	COG1684	flagellar biosynthetic protein fliR
TPE_RS05215	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TPE_RS05220	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TPE_RS05235	COG2217	Heavy metal translocating P-type atpase
TPE_RS05245	COG3829	transcription factor binding
TPE_RS05265	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TPE_RS05280	COG4545	Glutaredoxin-related protein
TPE_RS05295	COG0739	heme binding
TPE_RS05300	COG1418	mRNA catabolic process
TPE_RS05340	COG1120	ATPase activity
TPE_RS05360	COG1132	(ABC) transporter
TPE_RS05400	COG1120	ATPase activity
TPE_RS05415	COG0840	transmembrane signaling receptor activity
TPE_RS05445	COG0840	transmembrane signaling receptor activity
TPE_RS05450	COG4656	Part of a membrane complex involved in electron transport
TPE_RS05455	COG4658	electron transport chain
TPE_RS05460	COG4659	FMN binding
TPE_RS05465	COG4660	Part of a membrane complex involved in electron transport
TPE_RS05470	COG4657	Part of a membrane complex involved in electron transport
TPE_RS05490	COG0792	nuclease activity
TPE_RS05500	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TPE_RS05510	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TPE_RS05520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TPE_RS05525	COG0564	pseudouridine synthase activity
TPE_RS05530	COG0357	Ribosomal RNA small subunit methyltransferase G
TPE_RS05535	COG1012	belongs to the aldehyde dehydrogenase family
TPE_RS05540	COG1757	Na H antiporter
TPE_RS05545	COG4865	methylaspartate mutase activity
TPE_RS05565	COG0724	RNA recognition motif
TPE_RS05575	COG0534	Mate efflux family protein
TPE_RS05580	COG0420	3'-5' exonuclease activity
TPE_RS05585	COG0419	ATPase involved in DNA repair
TPE_RS05610	COG1187	pseudouridine synthase activity
TPE_RS05650	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TPE_RS05655	COG0154	amidase activity
TPE_RS05675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TPE_RS05690	COG0426	domain, Protein
TPE_RS05690	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TPE_RS05715	COG3118	belongs to the thioredoxin family
TPE_RS05730	COG1272	protein, Hemolysin III
TPE_RS05745	COG1047	Peptidyl-prolyl cis-trans
TPE_RS05780	COG0644	oxidoreductase
TPE_RS05785	COG2226	methyltransferase
TPE_RS05795	COG0142	geranyltranstransferase activity
TPE_RS05820	COG0003	Pfam Anion-transporting ATPase
TPE_RS05825	COG1620	l-lactate permease
TPE_RS05835	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TPE_RS05970	COG2361	Protein of unknown function DUF86
TPE_RS05985	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
TPE_RS06040	COG0588	phosphoglycerate mutase activity
TPE_RS06050	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TPE_RS06070	COG3177	Filamentation induced by cAMP protein fic
TPE_RS06155	COG0813	purine-nucleoside phosphorylase activity
TPE_RS06360	COG1132	(ABC) transporter
TPE_RS06395	COG0656	L-ascorbic acid biosynthetic process
TPE_RS06445	COG2207	Transcriptional regulator
TPE_RS06450	COG1132	(ABC) transporter
TPE_RS06455	COG1132	(ABC) transporter
TPE_RS06490	COG2855	membrane
TPE_RS06500	COG1129	ABC transporter
TPE_RS06515	COG2342	PFAM TM1410 hypothetical-related protein
TPE_RS06520	COG1744	ABC transporter substrate-binding protein PnrA-like
TPE_RS06525	COG3845	ABC transporter
TPE_RS06530	COG4603	Belongs to the binding-protein-dependent transport system permease family
TPE_RS06535	COG1079	Belongs to the binding-protein-dependent transport system permease family
TPE_RS06550	COG0126	phosphoglycerate kinase activity
TPE_RS06555	COG0860	N-Acetylmuramoyl-L-alanine amidase
TPE_RS06575	COG0268	Binds directly to 16S ribosomal RNA
TPE_RS06585	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TPE_RS06595	COG1058	Belongs to the CinA family
TPE_RS06595	COG1546	Belongs to the CinA family
TPE_RS06605	COG3681	Belongs to the UPF0597 family
TPE_RS06610	COG0840	transmembrane signaling receptor activity
TPE_RS06615	COG0617	tRNA 3'-terminal CCA addition
TPE_RS06625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TPE_RS06635	COG1132	(ABC) transporter
TPE_RS06640	COG1132	(ABC) transporter
TPE_RS06670	COG0343	queuine tRNA-ribosyltransferase activity
TPE_RS06690	COG0359	binds to the 23S rRNA
TPE_RS06695	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TPE_RS06700	COG0629	single-stranded DNA binding
TPE_RS06705	COG0360	Binds together with S18 to 16S ribosomal RNA
TPE_RS06715	COG3209	COG3209 Rhs family protein
TPE_RS06715	COG4104	PAAR repeat-containing protein
TPE_RS06740	COG2252	PERMEase
TPE_RS06755	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TPE_RS06765	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TPE_RS06770	COG0071	Belongs to the small heat shock protein (HSP20) family
TPE_RS06780	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TPE_RS06805	COG1132	(ABC) transporter
TPE_RS06810	COG1132	(ABC) transporter
TPE_RS06815	COG1120	ATPase activity
TPE_RS06820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPE_RS06825	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TPE_RS06830	COG0840	transmembrane signaling receptor activity
TPE_RS06835	COG2201	protein-glutamate methylesterase activity
TPE_RS06855	COG1137	ATPase activity
TPE_RS06860	COG0431	NADPH-dependent FMN reductase
TPE_RS06860	COG1053	succinate dehydrogenase
TPE_RS06860	COG3976	FMN-binding domain protein
TPE_RS06865	COG1418	mRNA catabolic process
TPE_RS06875	COG2195	Cleaves the N-terminal amino acid of tripeptides
TPE_RS06880	COG0124	histidyl-tRNA synthetase
TPE_RS06890	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TPE_RS06900	COG1193	negative regulation of DNA recombination
TPE_RS06910	COG3706	GGDEF domain
TPE_RS06965	COG3033	Beta-eliminating lyase
TPE_RS06970	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TPE_RS06980	COG3639	organic phosphonate transmembrane transporter activity
TPE_RS06985	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TPE_RS07005	COG0019	diaminopimelate decarboxylase activity
TPE_RS07010	COG0433	COG0433 Predicted ATPase
TPE_RS07020	COG4608	Belongs to the ABC transporter superfamily
TPE_RS07025	COG0444	Belongs to the ABC transporter superfamily
TPE_RS07030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TPE_RS07035	COG0601	transmembrane transport
TPE_RS07040	COG0747	negative chemotaxis
TPE_RS07045	COG0840	transmembrane signaling receptor activity
TPE_RS07070	COG1269	ATP hydrolysis coupled proton transport
TPE_RS07085	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TPE_RS07085	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TPE_RS07085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TPE_RS07090	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TPE_RS07100	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TPE_RS07105	COG2890	protein-(glutamine-N5) methyltransferase activity
TPE_RS07115	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TPE_RS07120	COG2088	sporulation resulting in formation of a cellular spore
TPE_RS07130	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TPE_RS07135	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TPE_RS07145	COG1592	Rubrerythrin
TPE_RS07150	COG1283	sodium-dependent phosphate transmembrane transporter activity
TPE_RS07170	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TPE_RS07175	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TPE_RS07180	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TPE_RS07235	COG0719	Fe-S assembly protein
TPE_RS07245	COG0583	DNA-binding transcription factor activity
TPE_RS07250	COG1131	(ABC) transporter
TPE_RS07260	COG0495	leucyl-tRNA aminoacylation
TPE_RS07290	COG1196	nuclear chromosome segregation
TPE_RS07300	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TPE_RS07655	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TPE_RS07670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPE_RS07680	COG0006	proline dipeptidase activity
TPE_RS07690	COG1181	Belongs to the D-alanine--D-alanine ligase family
TPE_RS07700	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TPE_RS07700	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TPE_RS07705	COG1102	Psort location Cytoplasmic, score
TPE_RS07710	COG1561	YicC-like family, N-terminal region
TPE_RS07720	COG0285	dihydrofolate synthase activity
TPE_RS07725	COG0564	pseudouridine synthase activity
TPE_RS07740	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TPE_RS07755	COG0803	Belongs to the bacterial solute-binding protein 9 family
TPE_RS07765	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TPE_RS07770	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TPE_RS07770	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TPE_RS07775	COG0739	heme binding
TPE_RS07775	COG1196	nuclear chromosome segregation
TPE_RS07775	COG0741	lytic transglycosylase activity
TPE_RS07785	COG1595	DNA-templated transcription, initiation
TPE_RS07800	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TPE_RS07805	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TPE_RS07810	COG1966	Carbon starvation protein
TPE_RS07815	COG3956	TIGRFAM MazG family protein
TPE_RS07830	COG0793	Belongs to the peptidase S41A family
TPE_RS07835	COG0534	Mate efflux family protein
TPE_RS07845	COG0549	Belongs to the carbamate kinase family
TPE_RS07855	COG0823	Involved in the tonB-independent uptake of proteins
TPE_RS07865	COG1199	ATP-dependent helicase activity
TPE_RS08070	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TPE_RS08090	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TPE_RS08100	COG0488	(ABC) transporter
TPE_RS08125	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TPE_RS08130	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TPE_RS08135	COG0058	SHG alpha-glucan phosphorylase activity
TPE_RS08150	COG0237	dephospho-CoA kinase activity
TPE_RS08155	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TPE_RS08155	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TPE_RS08155	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TPE_RS08165	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
TPE_RS08170	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TPE_RS08195	COG0398	Pfam SNARE associated Golgi protein
TPE_RS08205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TPE_RS08215	COG0668	transmembrane transport
TPE_RS08240	COG2897	thiosulfate sulfurtransferase activity
TPE_RS08290	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TPE_RS08290	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TPE_RS08295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TPE_RS08300	COG0358	DNA primase activity
TPE_RS08305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TPE_RS08325	COG1077	Cell shape determining protein MreB Mrl
TPE_RS08340	COG0768	penicillin binding
TPE_RS08345	COG0772	Belongs to the SEDS family
TPE_RS08365	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TPE_RS08370	COG0840	transmembrane signaling receptor activity
TPE_RS08380	COG1269	ATP hydrolysis coupled proton transport
TPE_RS08385	COG1394	ATPase activity, coupled to movement of substances
TPE_RS08390	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TPE_RS08395	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TPE_RS08400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TPE_RS08420	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TPE_RS08425	COG1794	racemase activity, acting on amino acids and derivatives
TPE_RS08435	COG4555	ABC transporter
TPE_RS08460	COG0217	transcriptional regulatory protein
TPE_RS08465	COG0138	bifunctional purine biosynthesis protein purh
TPE_RS08475	COG1362	aminopeptidase activity
TPE_RS08495	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TPE_RS08505	COG1115	amino acid carrier protein
TPE_RS08520	COG0799	negative regulation of ribosome biogenesis
TPE_RS08525	COG2059	Chromate
TPE_RS08545	COG1480	7TM receptor with intracellular HD hydrolase
TPE_RS08550	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TPE_RS08560	COG2885	chlorophyll binding
TPE_RS08565	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TPE_RS08600	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TPE_RS08615	COG0509	glycine decarboxylation via glycine cleavage system
TPE_RS08625	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TPE_RS08630	COG1722	exodeoxyribonuclease VII activity
TPE_RS08635	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TPE_RS08665	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TPE_RS08675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TPE_RS08700	COG1692	metallophosphoesterase
TPE_RS08710	COG0142	geranyltranstransferase activity
TPE_RS08725	COG4555	ABC transporter
TPE_RS08755	COG1115	amino acid carrier protein
TPE_RS08765	COG2195	Cleaves the N-terminal amino acid of tripeptides
TPE_RS08775	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TPE_RS08780	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TPE_RS08795	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TPE_RS08800	COG0156	8-amino-7-oxononanoate synthase activity
TPE_RS08805	COG2878	Part of a membrane complex involved in electron transport
TPE_RS08810	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TPE_RS08815	COG2183	response to ionizing radiation
TPE_RS08820	COG1363	Peptidase, m42
TPE_RS08825	COG0281	malic enzyme
TPE_RS08840	COG2738	Putative neutral zinc metallopeptidase
TPE_RS08845	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TPE_RS08845	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TPE_RS08860	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TPE_RS08865	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TPE_RS08880	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TPE_RS08885	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TPE_RS08910	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TPE_RS08915	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TPE_RS08915	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TPE_RS08920	COG1329	Transcriptional regulator
TPE_RS08935	COG1136	(ABC) transporter
TPE_RS08935	COG0577	efflux transmembrane transporter activity
TPE_RS08945	COG1136	(ABC) transporter
TPE_RS08945	COG0577	efflux transmembrane transporter activity
TPE_RS08955	COG0009	L-threonylcarbamoyladenylate synthase
TPE_RS08985	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
TPE_RS08990	COG2204	response regulator
TPE_RS08995	COG0539	negative regulation of cytoplasmic translation
TPE_RS09020	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TPE_RS09040	COG0497	DNA recombination
TPE_RS09060	COG1388	LysM domain
TPE_RS09065	COG1757	Na H antiporter
TPE_RS09070	COG0626	cystathionine gamma-synthase activity
TPE_RS09090	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TPE_RS09100	COG0488	(ABC) transporter
TPE_RS09105	COG2723	6-phospho-beta-galactosidase activity
TPE_RS09110	COG2211	Major facilitator Superfamily
TPE_RS09110	COG2190	(PTS) system
TPE_RS09125	COG0557	exoribonuclease II activity
TPE_RS09150	COG2017	converts alpha-aldose to the beta-anomer
TPE_RS09160	COG1162	GTPase activity
TPE_RS09165	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TPE_RS09175	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
TPE_RS09180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TPE_RS09190	COG2255	four-way junction helicase activity
TPE_RS09195	COG1979	alcohol dehydrogenase
TPE_RS09200	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TPE_RS09215	COG3880	PFAM UvrB UvrC protein
TPE_RS09225	COG1136	(ABC) transporter
TPE_RS09240	COG0552	protein localization to endoplasmic reticulum
TPE_RS09255	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TPE_RS09275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TPE_RS09290	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TPE_RS09295	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TPE_RS09315	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TPE_RS09320	COG1309	transcriptional regulator
TPE_RS09325	COG1132	(ABC) transporter
TPE_RS09330	COG1129	ABC transporter
TPE_RS09345	COG0488	(ABC) transporter
TPE_RS09360	COG2264	protein methyltransferase activity
TPE_RS09375	COG4608	Belongs to the ABC transporter superfamily
TPE_RS09380	COG0444	Belongs to the ABC transporter superfamily
TPE_RS09385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TPE_RS09390	COG0601	transmembrane transport
TPE_RS09400	COG0312	modulator of DNA gyrase
TPE_RS09420	COG2604	Protein of unknown function DUF115
TPE_RS09425	COG0484	heat shock protein binding
TPE_RS09430	COG0443	Heat shock 70 kDa protein
TPE_RS09435	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TPE_RS09440	COG0284	orotidine-5'-phosphate decarboxylase activity
TPE_RS09450	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TPE_RS09455	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TPE_RS09465	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TPE_RS09475	COG0825	malonyl-CoA metabolic process
TPE_RS09480	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TPE_RS09485	COG0439	Biotin carboxylase
TPE_RS09490	COG0511	ligase activity, forming carbon-carbon bonds
TPE_RS09495	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TPE_RS09500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TPE_RS09505	COG1028	Short-chain dehydrogenase reductase Sdr
TPE_RS09510	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TPE_RS09515	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TPE_RS09525	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TPE_RS09550	COG0330	HflC and HflK could
TPE_RS09555	COG0330	HflC and HflK could
TPE_RS09565	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
TPE_RS09585	COG0835	chemotaxis
TPE_RS09595	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TPE_RS09600	COG1132	(ABC) transporter
TPE_RS09605	COG2084	Dehydrogenase
TPE_RS09610	COG2986	histidine ammonia-lyase
TPE_RS09620	COG1131	(ABC) transporter
TPE_RS09635	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TPE_RS09770	COG0442	prolyl-tRNA aminoacylation
TPE_RS09775	COG4608	Belongs to the ABC transporter superfamily
TPE_RS09780	COG0444	Belongs to the ABC transporter superfamily
TPE_RS09785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TPE_RS09790	COG0601	transmembrane transport
TPE_RS09795	COG4166	transmembrane transport
TPE_RS09810	COG2982	Protein involved in outer membrane biogenesis
TPE_RS09815	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
TPE_RS09820	COG0297	glycogen (starch) synthase activity
TPE_RS09830	COG4475	Protein of unknown function (DUF436)
TPE_RS09845	COG1472	Belongs to the glycosyl hydrolase 3 family
TPE_RS09860	COG1157	protein secretion by the type III secretion system
TPE_RS09865	COG1317	bacterial-type flagellum organization
TPE_RS09875	COG1766	The M ring may be actively involved in energy transduction
TPE_RS09880	COG1677	Flagellar hook-basal body complex protein FliE
TPE_RS09895	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TPE_RS09900	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TPE_RS09905	COG4974	Belongs to the 'phage' integrase family
TPE_RS09910	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TPE_RS09910	COG0551	DNA topoisomerase type I activity
TPE_RS09915	COG0758	DNA mediated transformation
TPE_RS09915	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TPE_RS09930	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TPE_RS09945	COG0772	Belongs to the SEDS family
TPE_RS09950	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TPE_RS09960	COG0275	rRNA processing
TPE_RS09965	COG2001	Belongs to the MraZ family
TPE_RS09990	COG0513	Belongs to the DEAD box helicase family
TPE_RS10000	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
TPE_RS10015	COG1739	Uncharacterized protein family UPF0029
TPE_RS10035	COG0747	negative chemotaxis
TPE_RS10040	COG0601	transmembrane transport
TPE_RS10045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TPE_RS10060	COG2226	methyltransferase
TPE_RS10065	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TPE_RS10075	COG0481	GTPase activity
TPE_RS10090	COG0750	zinc metalloprotease
TPE_RS10095	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TPE_RS10100	COG0575	Belongs to the CDS family
TPE_RS10105	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TPE_RS10110	COG0233	cytoplasmic translational termination
TPE_RS10115	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TPE_RS10120	COG0052	Belongs to the universal ribosomal protein uS2 family
TPE_RS10200	COG3209	COG3209 Rhs family protein
TPE_RS10250	COG0312	modulator of DNA gyrase
TPE_RS10255	COG0312	modulator of DNA gyrase
TPE_RS10260	COG3052	prosthetic group binding
TPE_RS10270	COG3051	citrate lyase alpha subunit
TPE_RS10285	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TPE_RS10290	COG0484	heat shock protein binding
TPE_RS10295	COG0528	UMP kinase activity
TPE_RS10300	COG0736	holo-[acyl-carrier-protein] synthase activity
TPE_RS10310	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TPE_RS10315	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TPE_RS10320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TPE_RS10325	COG0424	maF-like protein
TPE_RS10330	COG1413	lyase activity
TPE_RS10340	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TPE_RS10345	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TPE_RS10350	COG1334	flagellar protein FlaG
TPE_RS10355	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TPE_RS10355	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TPE_RS10370	COG0802	atpase or kinase
TPE_RS10380	COG3437	response regulator, receiver
TPE_RS10385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TPE_RS10390	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TPE_RS10395	COG2204	response regulator
TPE_RS10450	COG0731	radical SAM domain protein
TPE_RS10470	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TPE_RS10475	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
TPE_RS10480	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TPE_RS10500	COG1053	succinate dehydrogenase
TPE_RS10535	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
TPE_RS10540	COG3118	belongs to the thioredoxin family
TPE_RS10545	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TPE_RS10565	COG0492	ferredoxin-NADP+ reductase activity
TPE_RS10580	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TPE_RS10595	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TPE_RS10600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TPE_RS10605	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TPE_RS10625	COG0740	serine-type endopeptidase activity
TPE_RS10635	COG0193	aminoacyl-tRNA hydrolase activity
TPE_RS10665	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TPE_RS10695	COG0653	protein targeting
TPE_RS10710	COG3706	GGDEF domain
TPE_RS10735	COG1639	'signal transduction protein
TPE_RS10745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TPE_RS10750	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TPE_RS10755	COG1477	protein flavinylation
TPE_RS10760	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TPE_RS10805	COG0493	'glutamate synthase
TPE_RS10805	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TPE_RS10815	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TPE_RS10820	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TPE_RS10835	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TPE_RS10855	COG0459	protein refolding
TPE_RS10865	COG5341	Protein conserved in bacteria
TPE_RS10870	COG0577	efflux transmembrane transporter activity
TPE_RS10870	COG1136	(ABC) transporter
TPE_RS10875	COG0826	peptidase U32
TPE_RS10885	COG1132	(ABC) transporter
TPE_RS10910	COG1122	ATPase activity
TPE_RS10925	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TPE_RS10930	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TPE_RS10945	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TPE_RS10980	COG1131	(ABC) transporter
TPE_RS10985	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TPE_RS10990	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TPE_RS10995	COG1862	Preprotein translocase
TPE_RS11000	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TPE_RS11005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TPE_RS11010	COG0571	ribonuclease III activity
TPE_RS11015	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TPE_RS11020	COG1573	uracil-dna glycosylase
TPE_RS11030	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TPE_RS11035	COG0563	adenylate kinase activity
TPE_RS11055	COG0739	heme binding
TPE_RS11090	COG0556	nucleotide-excision repair
TPE_RS11095	COG0254	rRNA binding
TPE_RS11135	COG2217	Heavy metal translocating P-type atpase
TPE_RS11140	COG0640	Transcriptional regulator
TPE_RS11165	COG0784	Response regulator, receiver
TPE_RS11165	COG3437	response regulator, receiver
TPE_RS11170	COG1921	L-seryl-tRNASec selenium transferase activity
TPE_RS11175	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TPE_RS11185	COG2003	Belongs to the UPF0758 family
TPE_RS11195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TPE_RS11205	COG1132	(ABC) transporter
TPE_RS11210	COG0457	Tetratricopeptide repeat
TPE_RS11235	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TPE_RS11255	COG1132	(ABC) transporter
TPE_RS11280	COG0456	acetyltransferase
TPE_RS11445	COG0564	pseudouridine synthase activity
TPE_RS11460	COG4656	Part of a membrane complex involved in electron transport
TPE_RS11510	COG3833	ABC-type maltose transport systems, permease component
TPE_RS11515	COG3842	ATPase activity
TPE_RS11520	COG1640	4-alpha-glucanotransferase
TPE_RS11535	COG0779	Required for maturation of 30S ribosomal subunits
TPE_RS11545	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TPE_RS11550	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TPE_RS11555	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TPE_RS11575	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TPE_RS11580	COG0049	tRNA binding
TPE_RS11585	COG0791	NLP P60 protein
TPE_RS11590	COG0318	PFAM AMP-dependent synthetase and ligase
TPE_RS11640	COG1609	Transcriptional regulator
TPE_RS11660	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TPE_RS11665	COG0151	Belongs to the GarS family
TPE_RS11670	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TPE_RS11675	COG0300	oxidoreductase activity
TPE_RS11680	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TPE_RS11700	COG1704	LemA family
TPE_RS11705	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TPE_RS11710	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TPE_RS11720	COG0482	sulfurtransferase activity
TPE_RS11770	COG4608	Belongs to the ABC transporter superfamily
TPE_RS11775	COG0444	Belongs to the ABC transporter superfamily
TPE_RS11780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TPE_RS11785	COG0601	transmembrane transport
TPE_RS11795	COG1505	serine-type exopeptidase activity
TPE_RS11800	COG4166	transmembrane transport
TPE_RS11810	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TPE_RS11835	COG0617	tRNA 3'-terminal CCA addition
TPE_RS11860	COG1078	dGTPase activity
TPE_RS11870	COG0047	phosphoribosylformylglycinamidine synthase activity
TPE_RS11880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TPE_RS11885	COG0569	domain protein
TPE_RS11910	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TPE_RS11915	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TPE_RS11930	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TPE_RS11935	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TPE_RS11945	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
TPE_RS11950	COG1671	Belongs to the UPF0178 family
TPE_RS11965	COG0444	Belongs to the ABC transporter superfamily
TPE_RS11970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TPE_RS11975	COG0601	transmembrane transport
TPE_RS11980	COG0747	negative chemotaxis
TPE_RS11990	COG0840	transmembrane signaling receptor activity
TPE_RS12020	COG0335	large ribosomal subunit rRNA binding
TPE_RS12025	COG0336	Belongs to the RNA methyltransferase TrmD family
TPE_RS12030	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TPE_RS12035	COG1837	Belongs to the UPF0109 family
TPE_RS12040	COG0228	four-way junction DNA binding
TPE_RS12045	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TPE_RS12060	COG0534	Mate efflux family protein
TPE_RS12065	COG1309	transcriptional regulator
TPE_RS12075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TPE_RS12080	COG1285	pathogenesis
TPE_RS12100	COG1131	(ABC) transporter
TPE_RS12105	COG4953	penicillin-binding protein 1C
TPE_RS12110	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TPE_RS12125	COG0084	hydrolase, TatD family'
TPE_RS12135	COG0709	Synthesizes selenophosphate from selenide and ATP
TPE_RS12150	COG1286	toxin biosynthetic process
TPE_RS12155	COG0470	DNA polymerase III
TPE_RS12160	COG5002	protein histidine kinase activity
TPE_RS12165	COG0450	alkyl hydroperoxide reductase
TPE_RS12170	COG0708	Exodeoxyribonuclease III
TPE_RS12175	COG0024	Methionine aminopeptidase
TPE_RS12180	COG0484	heat shock protein binding
TPE_RS12235	COG4211	Belongs to the binding-protein-dependent transport system permease family
TPE_RS12240	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TPE_RS12270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPE_RS12300	COG1132	(ABC) transporter
TPE_RS12310	COG0203	ribosomal protein L17
TPE_RS12315	COG0202	RNA polymerase activity
TPE_RS12320	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TPE_RS12325	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TPE_RS12335	COG0200	Binds to the 23S rRNA
TPE_RS12340	COG1841	ribosomal large subunit assembly
TPE_RS12345	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TPE_RS12350	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TPE_RS12355	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TPE_RS12360	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TPE_RS12365	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TPE_RS12370	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TPE_RS12375	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TPE_RS12380	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TPE_RS12385	COG0255	Belongs to the universal ribosomal protein uL29 family
TPE_RS12390	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TPE_RS12395	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TPE_RS12400	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TPE_RS12405	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TPE_RS12410	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TPE_RS12415	COG0089	rRNA binding
TPE_RS12420	COG0088	Forms part of the polypeptide exit tunnel
TPE_RS12425	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TPE_RS12430	COG0051	transcription antitermination factor activity, RNA binding
TPE_RS12435	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TPE_RS12445	COG0714	Associated with various cellular activities
TPE_RS12450	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TPE_RS12480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TPE_RS12495	COG0840	transmembrane signaling receptor activity
TPE_RS12510	COG0657	acetylesterase activity
TPE_RS12560	COG0488	(ABC) transporter
TPE_RS12575	COG0446	pyridine nucleotide-disulphide oxidoreductase
TPE_RS12615	COG2378	regulation of single-species biofilm formation
TPE_RS12630	COG2207	Transcriptional regulator
TPE_RS12630	COG3708	Transcriptional regulator
TPE_RS12650	COG1053	succinate dehydrogenase
TPE_RS12650	COG3976	FMN-binding domain protein
TPE_RS12655	COG1120	ATPase activity
TPE_RS12660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPE_RS12665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPE_RS12670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TPE_RS12690	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TPE_RS12720	COG1067	ATP-dependent peptidase activity
TPE_RS12730	COG2199	diguanylate cyclase activity
TPE_RS12750	COG0205	6-phosphofructokinase activity
TPE_RS12755	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TPE_RS12760	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TPE_RS12765	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TPE_RS12785	COG0149	triose-phosphate isomerase activity
TPE_RS12790	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TPE_RS12795	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TPE_RS12805	COG0534	Mate efflux family protein
TPE_RS12810	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TPE_RS12820	COG0588	phosphoglycerate mutase activity
TPE_RS12840	COG0305	Participates in initiation and elongation during chromosome replication
TPE_RS12855	COG1193	negative regulation of DNA recombination
TPE_RS12870	COG2304	oxidoreductase activity
TPE_RS12895	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TPE_RS12915	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TPE_RS12920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TPE_RS12925	COG1121	(ABC) transporter
TPE_RS12930	COG0803	Belongs to the bacterial solute-binding protein 9 family
TPE_RS12965	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TPE_RS12970	COG3093	addiction module antidote protein HigA
TPE_RS12985	COG0205	6-phosphofructokinase activity
TPE_RS13005	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TPE_RS13015	COG1847	R3H domain protein
TPE_RS13020	COG0706	membrane insertase activity
TPE_RS13025	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TPE_RS13035	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TPE_RS13040	COG3314	Sporulation integral membrane protein YlbJ
TPE_RS13045	COG0813	purine-nucleoside phosphorylase activity
TPE_RS13075	COG3706	GGDEF domain
TPE_RS13100	COG1234	tRNA 3'-trailer cleavage
TPE_RS13115	COG3951	Flagellar rod assembly protein muramidase FlgJ
TPE_RS13120	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TPE_RS13165	COG3842	ATPase activity
TPE_RS13170	COG0514	ATP-dependent DNA helicase (RecQ)
TPE_RS13175	COG0187	DNA topoisomerase II activity
TPE_RS13225	COG0840	transmembrane signaling receptor activity
TPE_RS13325	COG3209	COG3209 Rhs family protein
TPE_RS13330	COG4106	trans-aconitate 2-methyltransferase activity
TPE_RS13435	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides